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Molecular Geometry, Frontier Molecular Orbitals, and Spectroscopic Analysis of 2-(4-Formylbenzyl)malononitrile: A Combined Experimental and Computational Laboratory Experiment 2-(4-甲酰基苄基)丙二腈的分子几何、前沿分子轨道和光谱分析:一个综合实验和计算实验室实验
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-15 DOI: 10.1021/acs.jchemed.5c01266
Perumal Venkatesan, , , Enrique Pérez-Gutiérrez, , , Paulina Ceballos, , , Subbiah Thamotharan, , and , M. Judith Percino*, 

Computational molecular modeling, with its powerful visualization capabilities, enhances students’ understanding of chemical concepts across various subfields. Introducing quantum chemical calculations at the undergraduate level is essential, but it presents academic challenges. To address this, we developed an integrated learning approach that combines experimental and computational spectroscopy, molecular geometry, and electronic structure analysis using 2-(4-formylbenzyl) malononitrile as a model compound. This educational module enables students to explore the structural elucidation of simple organic compounds and compare gas-phase optimized geometrical parameters with corresponding experimental data. Through this process, students gain deeper insight into fundamental chemical concepts such as molecular geometry, bonding, and structure–property relationships. By bridging theoretical concepts with hands-on research experience, this current study offers an effective strategy for incorporating advanced computational chemistry and crystallographic structure analysis into undergraduate curriculum.

计算分子建模以其强大的可视化能力,增强了学生对化学各个子领域概念的理解。在本科阶段引入量子化学计算是必要的,但它提出了学术挑战。为了解决这个问题,我们开发了一种综合学习方法,将实验和计算光谱、分子几何和电子结构分析结合起来,使用2-(4-甲酰基苄基)丙二腈作为模型化合物。这个教育模块使学生能够探索简单有机化合物的结构解析,并将气相优化的几何参数与相应的实验数据进行比较。通过这个过程,学生们对基本的化学概念有了更深入的了解,如分子几何、键和结构-性质关系。通过将理论概念与实践研究经验相结合,本研究为将先进的计算化学和晶体结构分析纳入本科课程提供了有效的策略。
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引用次数: 0
Adapting Master’s-Level Chemistry Education in the United States: Insights from Industry, Academia, and the Literature 适应美国硕士水平的化学教育:来自工业界、学术界和文献的见解
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-12 DOI: 10.1021/acs.jchemed.5c00418
Brian Johnson, , , Amanda Lindell, , and , Nina M. Goodey*, 

As the chemical industry evolves in response to technological and global challenges, Master’s-level chemistry programs must adapt to prepare graduates for workforce success. This article explores how such programs can better integrate professional skills such as communication, collaboration, and research. Drawing on literature and stakeholder interviews from a review of the Chemistry M.S. and Pharmaceutical Biochemistry M.S. programs at Montclair State University, a Hispanic Serving Institution in New Jersey’s pharmaceutical hub, we identified four key themes: the importance of hands-on research experiences, the integration of professional skills development, the need for flexible course and credit requirements, and the challenges of sustaining small programs. While independent research offers valuable experience, access can be limited by students’ financial and time constraints. Financial support and even brief, course-based research opportunities can mitigate this gap. Using experiential learning and communities of practice as guiding frameworks, we offer actionable recommendations for increasing curriculum relevance, equity, and workforce alignment. The insights are broadly applicable to institutions seeking to modernize master’s level chemistry education for a diverse student population.

随着化学工业在应对技术和全球挑战方面的发展,硕士水平的化学课程必须适应以使毕业生为职场成功做好准备。本文探讨了这些程序如何更好地整合专业技能,如沟通、协作和研究。根据对蒙特克莱尔州立大学化学硕士和药物生物化学硕士项目的文献和利益相关者访谈,我们确定了四个关键主题:实践研究经验的重要性,专业技能发展的整合,灵活的课程和学分要求的必要性,以及维持小项目的挑战。蒙特克莱尔州立大学是新泽西州制药中心的西班牙裔服务机构。虽然独立研究提供了宝贵的经验,但学生的经济和时间限制可能会限制他们的机会。财政支持,甚至是短暂的、基于课程的研究机会,都可以缓解这一差距。利用经验学习和实践社区作为指导框架,我们为提高课程相关性、公平性和劳动力一致性提供了可操作的建议。这些见解广泛适用于寻求现代化硕士水平化学教育的机构,以满足不同的学生群体。
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引用次数: 0
Fabrication and Property Studies of Multifunctional Hydrogel Dressing for Promoting Wound Healing: Introducing Chemistry Students to the Applications of Hydrogels in Biomedical Fields 促进伤口愈合的多功能水凝胶敷料的制备与性能研究:向化学专业学生介绍水凝胶在生物医学领域的应用
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-11 DOI: 10.1021/acs.jchemed.4c01047
Hua Zheng*, , , Yanni Zhang, , , Hairuo Qin, , , Changjie Yin, , , Dezhong Yin*, , and , Qiuyu Zhang*, 

Interdisciplinary integration is an inevitable trend in the development of science and technology, as well as the reform and development of higher education. With the rapid development of biomaterials in the pharmaceutical and medical industries, many undergraduate students in chemistry and materials science have been focusing on life sciences as well as pursuing careers in healthcare. Hydrogel, as a kind of biomaterial, has been widely applied in biomedical fields including 3D cell culture, protein delivery, controlled release of drugs, and tissue engineering repair due to its excellent biocompatibility, biodegradability, and similarity with human soft tissue in composition, structure, and properties. Therefore, we believe that it is crucial for undergraduates to be exposed to the fabrication and property studies of biomedical hydrogel before they pursue further graduate education or a career in biomedical fields. In this laboratory experiment, a multifunctional hydrogel dressing fabricated by methacryloyl hyaluronic acid (HA-GMA) and tannic acid (TA) for skin wound healing is designed for the undergraduates. This interdisciplinary experiment not only covers the hydrogel’s preparation, structural characterization, and physical multifunction measurement but also involves its biological multifunctional evaluation for promoting wound healing at the cell/bacterial level. Students indicate that this experiment reflects the interdisciplinary of chemistry, materials, and biology, which reinforces their chemistry experiment skills, expands their interdisciplinary knowledge and experimental skills, enriches their exposure to instruments, and increases their interest in the medicinal applications of biomaterials.

跨学科融合是科学技术发展的必然趋势,也是高等教育改革与发展的必然趋势。随着生物材料在制药和医疗行业的快速发展,许多化学和材料科学专业的本科生将重点放在生命科学以及医疗保健领域。水凝胶作为一种生物材料,由于其优异的生物相容性、生物可降解性以及与人体软组织在组成、结构和性能上的相似性,在三维细胞培养、蛋白质递送、药物控释、组织工程修复等生物医学领域得到了广泛的应用。因此,我们认为,对于本科生来说,在继续研究生教育或从事生物医学领域的职业之前,接触生物医学水凝胶的制造和性质研究是至关重要的。本实验为大学生设计了一种由甲基丙烯酰透明质酸(HA-GMA)和单宁酸(TA)制备的用于皮肤伤口愈合的多功能水凝胶敷料。本跨学科实验不仅涵盖了水凝胶的制备、结构表征和物理多功能测量,还涉及其在细胞/细菌水平上促进伤口愈合的生物学多功能评估。学生反映该实验体现了化学、材料和生物学的交叉学科,增强了他们的化学实验技能,拓展了他们的跨学科知识和实验技能,丰富了他们对仪器的接触,增加了他们对生物材料医学应用的兴趣。
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引用次数: 0
Integrating Local Culture into Middle School Chemistry Education: A Lesson on Well Salt Production 将地方文化融入中学化学教学——以井盐生产为例
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-11 DOI: 10.1021/acs.jchemed.5c00459
Bingjie Chen*, 

This article explores the integration of well salt production in southwest China, a culturally relevant real-world context, into middle school chemistry education. The lesson aimed to engage students in meaningful learning by helping them apply their existing chemistry knowledge to address real-world problems. Recognizing the complexity of these problems, the lesson also incorporated interdisciplinary and sustainability education to encourage students to develop a holistic understanding of real-world issues. The lesson was structured into three stages: a Pre-Class Preparation Stage, where students researched the origins of locally sold salt to introduce well salt; a Classroom Inquiry Stage, where they investigated ancient Chinese methods of well salt production, including salt crystallization, fuel selection, and impurity removal techniques; and a Post-Class Extension Stage, where they explored modern well salt production. Based on student feedback collected through postlesson surveys, the lesson successfully met its educational objectives, facilitated student knowledge construction, and enhanced their problem-solving skills, while helping them develop an appreciation for cultural significance, interdisciplinary connections, and responsible citizenship.

本文探讨了西南地区井盐生产与中学化学教育相结合的现实文化背景。这节课旨在通过帮助学生运用现有的化学知识来解决现实问题,从而使学生参与到有意义的学习中来。认识到这些问题的复杂性,课程还纳入了跨学科和可持续发展教育,以鼓励学生对现实世界的问题有一个全面的理解。课程分为三个阶段:课前准备阶段,学生研究当地出售的盐的来源,介绍井盐;在课堂探究阶段,他们研究了中国古代井盐生产方法,包括盐结晶、燃料选择和杂质去除技术;在课后推广阶段,他们探索了现代井盐生产。根据课后调查收集到的学生反馈,这节课成功地达到了教育目标,促进了学生的知识构建,提高了他们解决问题的能力,同时帮助他们培养了对文化意义、跨学科联系和负责任的公民意识。
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引用次数: 0
Instructional and Assessment Practices Used in Chemistry Courses at Two-Year Institutions: Results of a National Survey 两年制大学化学课程的教学和评估实践:一项全国调查的结果
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-11 DOI: 10.1021/acs.jchemed.5c01148
Kendall M. Zammit, , , Megan C. Connor, , and , Jeffrey R. Raker*, 

Studies on the teaching and learning of chemistry at two-year institutions are sparse compared to studies at four-year institutions. Two-year institutions, though, serve a sizable number of students taking chemistry courses that eventually enter the workforce directly or seek advanced studies at four-year institutions. There is little understanding of the instructional and assessment practices enacted at two-year institutions compared to peer-reviewed studies on the instructional and assessment practices at four-year institutions. Our work in this study provides a starting point for understanding such practices. A national survey was administered to faculty members at two-year postsecondary institutions in the United States with a focus on three key chemistry courses: general chemistry, organic chemistry, and general-organic-biochemistry (GOB). Descriptive statistics are provided for discussing the use of instructional and assessment practices and their implications for teaching and learning. We found that instructional and assessment practices used by two-year institutions mirror those used by four-year institutions: for example, lecture-based instruction and summative assessment predominate enacted practices. Results of our work suggest there is an opportunity to reflect on the practices used in chemistry course contexts at two-year institutions and a call for increasing collaboration between two-year and four-year institutions to best support students across all postsecondary chemistry courses.

与四年制大学相比,对两年制大学化学教学的研究较少。然而,两年制的大学为相当数量的化学课程学生提供服务,这些学生最终直接进入劳动力市场,或者在四年制大学继续深造。与四年制大学的教学和评估实践的同行评议研究相比,对两年制大学制定的教学和评估实践的了解很少。我们在这项研究中的工作为理解此类实践提供了一个起点。对美国两年制高等教育机构的教师进行了一项全国性调查,重点关注三个关键化学课程:普通化学、有机化学和普通有机生物化学(GOB)。描述性统计是用来讨论教学和评估实践的使用及其对教与学的影响。我们发现两年制院校使用的教学和评估实践反映了四年制院校使用的教学和评估实践:例如,以讲座为基础的教学和总结性评估占主导地位。我们的研究结果表明,我们有机会反思两年制大学化学课程背景中使用的实践,并呼吁加强两年制和四年制大学之间的合作,以最好地支持学生完成所有中学后化学课程。
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引用次数: 0
Metal–Organic Frameworks for Teaching Chemistry 金属-有机化学教学框架
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-09 DOI: 10.1021/acs.jchemed.5c01629
Donald Wink,  and , Thomas Holme*, 

The awarding of the 2025 Nobel Prize for work with Metal–Organic Frameworks (MOFs) presents a variety of connections to teaching and learning chemistry. A collection has been created of 31 articles that have appeared in the Journal where MOFs have been incorporated in the chemistry content of educational innovations. This editorial provides a brief description of this project.

2025年诺贝尔奖授予金属有机框架(mof)的研究,这与化学的教学和学习有多种联系。我们收集了31篇发表在《华尔街日报》上的文章,其中MOFs被纳入了教育创新的化学内容。这篇社论简要介绍了这个项目。
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引用次数: 0
Advancing Green Chemistry Education: Safe and Sustainable Click Chemistry with Biodegradable HPMC-Encapsulated Catalysts 推进绿色化学教育:生物可降解hpmc包封催化剂的安全和可持续点击化学
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-09 DOI: 10.1021/acs.jchemed.5c01002
Karanjeet Kaur, , , Ashik Chhetri, , , Amna Akram, , , Reda Zainab, , , Wilfried Braje, , , Nisha V. Handa*, , and , Sachin Handa*, 

The implementation of safe practices in undergraduate laboratories is paramount for mitigating accidents and fostering responsible laboratory techniques. This experiment introduces the use of biodegradable hydroxypropyl methylcellulose (HPMC) capsules for handling catalysts and a potentially hazardous but highly important and a useful reagent, sodium azide, in water-based two-step one-pot click chemistry, aligning with Green Chemistry Principles by emphasizing cleaner solvents, energy-efficient design, and the reduction of chemical waste while teaching an important organic transformation and essential technical skills to undergraduate students. In these domino nucleophilic substitution and click reactions, the post-reaction product is filtered, eliminating the reliance on toxic organic solvents for extraction and purification, while the generated waste can be repurposed within the research laboratory, thereby enhancing sustainability. Designed for a 3 h lab session, this experiment is characterized by its safety, reproducibility, adaptability, and intensive learning opportunity, making it suitable for different levels of the undergraduate curriculum. By engaging in this practice, students cultivate a sense of responsibility toward Green Chemistry and are better equipped to make environmentally informed decisions in future research or industry roles.

在本科生实验室实施安全操作对于减少事故和培养负责任的实验室技术至关重要。本实验介绍了在水基两步一锅式化学中使用可生物降解羟丙基甲基纤维素(HPMC)胶囊处理催化剂和一种潜在危险但非常重要和有用的试剂叠氮化钠,强调更清洁的溶剂,节能设计和减少化学废物,与绿色化学原则相一致,同时向本科生教授重要的有机转化和基本技术技能。在这些多米诺骨牌亲核取代和点击反应中,反应后的产物经过过滤,消除了对有毒有机溶剂的提取和纯化的依赖,而产生的废物可以在研究实验室内重新利用,从而提高了可持续性。本实验设计为3小时的实验时间,具有安全性、可重复性、适应性强和强化学习机会的特点,适合不同层次的本科课程。通过参与这种实践,学生培养了对绿色化学的责任感,并更好地为未来的研究或行业角色做出环境知情的决定做好准备。
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引用次数: 0
Designing the Fastest Diels–Alder Reaction: A Collaborative Miniature Research Project for Undergraduate Computational Chemistry 设计最快Diels-Alder反应:本科计算化学协作微型研究项目
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-09 DOI: 10.1021/acs.jchemed.5c00799
Bradley G. Welch, , , Ingso Limbu, , , Lawrence R. Gahan, , , Ross P. McGeary, , and , Elizabeth H. Krenske*, 

We describe a reaction design activity that targets the simultaneous development of students’ computational chemistry skills and research skills through the challenge of designing the fastest Diels–Alder reaction. The activity exposes students to core quantum chemistry techniques, such as optimizing the geometries of ground states and transition states, visualizing molecular orbitals and vibrations, calculating energy barriers, and comparing the accuracies and costs of different methods. By embedding these practices within a scaffolded, inquiry-based process, the activity aims to develop students’ investigative skills─designing a project, evaluating assumptions, dealing with setbacks, and collaborating with a team─thereby simulating authentic computational chemistry research. The activity can be conducted in a minimum of 8 h class time (e.g. four 2 h sessions) providing a self-contained, hands-on introduction to the practice of computational chemistry.

我们描述了一个反应设计活动,目标是同时发展学生的计算化学技能和研究技能,通过设计最快的Diels-Alder反应的挑战。该活动使学生接触到核心量子化学技术,如优化基态和过渡态的几何形状,可视化分子轨道和振动,计算能量势垒,比较不同方法的准确性和成本。通过将这些实践融入到以探究为基础的框架过程中,该活动旨在培养学生的调查技能──设计项目、评估假设、处理挫折以及与团队合作──从而模拟真正的计算化学研究。该活动可以在至少8小时的课堂时间内进行(例如四节2小时的课程),为计算化学的实践提供一个独立的、动手的介绍。
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引用次数: 0
Incorporating ChatGPT into a Simulated Peer-Review Assignment in an Upper-Level Materials Chemistry Course 在高级材料化学课程中,将ChatGPT纳入模拟同行评议作业
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-08 DOI: 10.1021/acs.jchemed.5c00790
Bryton R. Varju, , , Muhammad Ebad Noman, , , Andrew P. Dicks*, , and , Dwight S. Seferos*, 

The growing presence of generative artificial intelligence (GenAI), such as ChatGPT, has already begun to alter the scientific landscape. In addition to the utility of GenAI, there are also concerns about its ethical use. The rapid introduction of GenAI means that science undergraduate curricula need to be updated to address this technological evolution. To that end, we report here an assignment for an organic materials chemistry course incorporating ChatGPT. This two week activity involves students using ChatGPT to generate short essays on course topics and then critiquing and editing the generated information. Students reported that this assignment helped their understanding of the course topics and that they enjoyed the activity overall. Additionally, we address some of the issues we encountered when implementing this assignment due to the unpredictable nature of ChatGPT, and the solutions we found for them. Overall, students felt that this assignment was valuable for improving their grasp of the course topics without an excessive time commitment.

像ChatGPT这样的生成式人工智能(GenAI)的出现越来越多,已经开始改变科学领域的格局。除了基因人工智能的实用性之外,人们还担心它的伦理使用。基因人工智能的迅速引入意味着科学本科课程需要更新以应对这种技术演变。为此,我们在此报告一个有机材料化学课程的作业,其中包含ChatGPT。这个为期两周的活动要求学生使用ChatGPT就课程主题生成短文,然后对生成的信息进行评论和编辑。学生们报告说,这项作业帮助他们理解了课程主题,总体来说,他们很喜欢这项活动。此外,我们还解决了由于ChatGPT的不可预测性而在实现此任务时遇到的一些问题,以及我们为它们找到的解决方案。总的来说,学生们认为这项作业对于提高他们对课程主题的把握很有价值,而且没有过多的时间承诺。
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引用次数: 0
Revisiting and Upscaling “The Preparation of a Fluorescent Dye: A Microscale Experiment” “荧光染料的制备:微尺度实验”重访与升级
IF 2.9 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-08 DOI: 10.1021/acs.jchemed.5c00998
Damir Medunjanin, , , Tjalling R. Canrinus, , , Roan Fraser*, , and , Niek N. H. M. Eisink*, 

A microscale synthesis of a naphthalimide fluorescent was redesigned, upscaled, and integrated into the syllabus of an undergraduate introductory organic chemistry laboratory course as an inquiry-based experiment teaching basic thin layer chromatography (TLC) techniques. The students’ goal is to monitor the reaction of 4-chloro-1,8-naphthalic anhydride with different primary amines using TLC, as part of a two-day project cycle, and students were required to submit a written report for summative assessment. Students generally encounter four fluorescent spots: two blue and two yellow. To evaluate the students’ overall experience in conducting this experiment over two consecutive academic years, they were asked to report on their confidence and excitement levels at both the beginning and end of the project cycle. The results showed that the majority of the students felt more confident and excited about the experiment after its completion, reporting an increase above 80% and 60% for both years, respectively.

本文对一种萘酰亚胺荧光的微尺度合成方法进行了重新设计、升级,并将其整合到本科有机化学实验入门课程的教学大纲中,作为一种基于探究式的基础薄层色谱(TLC)技术实验教学。学生的目标是使用TLC监测4-氯-1,8-萘酸酐与不同伯胺的反应,作为为期两天的项目周期的一部分,学生需要提交书面报告进行总结性评估。学生通常会遇到四个荧光点:两个蓝色和两个黄色。为了评估学生在连续两个学年中进行这项实验的总体体验,他们被要求报告他们在项目周期开始和结束时的信心和兴奋程度。结果显示,大多数学生在完成实验后感到更加自信和兴奋,两年分别增长了80%和60%以上。
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引用次数: 0
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Journal of Chemical Education
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