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Developing a Threshold Concept Assessment Rubric: Using the Johnstone's Triangle Framework for Understanding Intermolecular Forces. 制定阈限概念评估标准:使用约翰斯通三角框架理解分子间作用力。
IF 2.5 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-02 eCollection Date: 2024-11-12 DOI: 10.1021/acs.jchemed.4c00236
Simbarashe Nkomo, Alia Bly

In undergraduate science education, laboratory courses stand as essential cornerstones of experiential learning. Chemistry laboratory courses offer students unique hands-on experiences that bridge the gap between theoretical knowledge and practical application. The journey through the undergraduate chemistry curriculum is paved with a series of conceptual gateways known as threshold concepts that can dramatically shape a student's understanding and success. We identified the idea of intermolecular forces (IMFs) as a threshold concept to students' ability to link molecular structures, properties, and applications to real-world problems such as extraction and separation of compounds. The development of course-specific pedagogical tools can provide students with the scaffolding necessary for the transition from novice to expert-level disciplinary comprehension. This work presents the development process of a Threshold Concept Assessment Rubric (TCAR) based on Johnstone's triangle framework and discusses its application for evaluating students' progress in overcoming a threshold concept. The rubric is used in a 200-level multilayer laboratory course that is intentionally designed with intermolecular forces as the central theme. We analyze the role and structure of different questions to provide a holistic assessment of students' learning processes using sample assignments. Furthermore, we demonstrate how insights from statistical analyses can highlight areas in which students struggle to gain expert or exemplary-level understanding of IMFs. This rubric development approach can be applied to other threshold concepts.

在本科科学教育中,实验课程是体验式学习的重要基石。化学实验课程为学生提供了独特的实践经验,在理论知识和实际应用之间架起了一座桥梁。在本科化学课程的学习过程中,有一系列被称为 "门槛概念 "的概念门径,它们可以极大地影响学生的理解和成功。我们发现,分子间作用力(IMFs)是学生将分子结构、性质和应用与实际问题(如化合物的萃取和分离)联系起来的一个门槛概念。开发针对特定课程的教学工具可以为学生提供从新手到专家级学科理解过渡所需的支架。本作品介绍了基于约翰斯通三角形框架的阈值概念评估标准(TCAR)的开发过程,并讨论了其在评估学生克服阈值概念的进展方面的应用。该评分标准用于一门 200 级多层实验课程,该课程有意将分子间作用力作为中心主题。我们分析了不同问题的作用和结构,以便利用作业样本对学生的学习过程进行整体评估。此外,我们还展示了如何通过统计分析来突出学生在获得专家或模范水平的 IMF 理解方面所面临的困难。这种评分标准开发方法可应用于其他阈值概念。
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引用次数: 0
Addition to “Interactions 500: Design, Implementation, and Evaluation of a Hybrid Board Game for Aiding Students in the Review of Intermolecular Forces During Covid-19 Pandemic”
IF 2.5 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-02 DOI: 10.1021/acs.jchemed.4c0094610.1021/acs.jchemed.4c00946
José Nunes da Silva Júnior*, José Mariano de Sousa Oliveira, Jean-Yves Winum, Antonio José Melo Leite Junior, Francisco Serra Oliveira Alexandre, David Macedo do Nascimento, Ulisses Silva de Sousa, Antônia Torres Ávila Pimenta and André Jalles Monteiro, 
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引用次数: 0
Structuring Materials to Support Student Learning: Analysis of Instructional Materials from a Professional Development Workshop. 构建支持学生学习的材料:专业发展研讨会教学材料分析。
IF 2.5 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-30 eCollection Date: 2024-11-12 DOI: 10.1021/acs.jchemed.4c00783
Andrew Kreps, Ian Brown, Thomas J Wenzel, Renée Cole

Faculty development programs play a crucial role in enhancing learning by equipping educators with the necessary skills, knowledge, and pedagogical strategies to teach more effectively. One such program is the Promoting Active Learning in Analytical Chemistry (PALAC) workshop, which aimed to educate faculty on methods to create and use active learning course materials to support students during the process of learning. This research aimed to assess the design of classroom instructional materials generated by faculty that attended the PALAC workshops. The theories of Vygotsky's zone of proximal development and scaffolding were used as lenses to characterize the materials because they describe the benefits of providing support through the process of developing knowledge. The active learning materials were analyzed by assigning the cognitive levels of processing, as described by Marzano's taxonomy, to all questions asked across 134 in-class activities. The use of the cognitive levels of processing allowed the researchers to gauge the presence of scaffolding by tracking how the cognitive levels of processing changed from question to question across each in-class activity. The results from this study indicate that the majority of materials provide opportunities for students to engage with higher-order questions, but there is less evidence for the effective and consistent structuring of the materials. These results have implications for future faculty development programs, suggesting the need to allot more time for faculty to practice developing effective classroom materials. In conjunction, this work demonstrates the effective use of Marzano's taxonomy in assessing the cognitive structure of in-class activities.

教师发展计划通过向教育工作者传授必要的技能、知识和教学策略来提高教学效率,从而在促进学习方面发挥着至关重要的作用。促进分析化学主动学习 (PALAC) 研讨班就是这样一个项目,其目的是向教师传授创建和使用主动学习课程材料的方法,以便在学习过程中为学生提供支持。本研究旨在评估参加 PALAC 研讨班的教师所设计的课堂教学材料。维果茨基的 "近端发展区 "和 "支架 "理论被用来描述教材的特点,因为它们描述了在知识发展过程中提供支持的益处。在对主动学习材料进行分析时,按照马扎诺分类学的描述,对 134 个课堂活动中提出的所有问题进行了认知水平处理。通过使用认知加工等级,研究人员可以跟踪每个课堂活动中不同问题的认知加工等级是如何变化的,从而衡量是否存在支架。这项研究的结果表明,大多数教材都为学生提供了参与高阶问题的机会,但较少证据表明教材结构的有效性和一致性。这些结果对未来的教师发展计划有一定的影响,表明有必要为教师分配更多的时间来练习编写有效的课堂材料。同时,这项研究还证明了马扎诺分类法在评估课堂活动认知结构方面的有效应用。
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引用次数: 0
Complementary Instrumental Techniques Applied to Pain Relieving Tablets in an Undergraduate Laboratory Experiment 本科生实验中应用于止痛片的辅助仪器技术
IF 3 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-20 DOI: 10.1021/acs.jchemed.4c00681
Klaudia Adels, Vera Thönnessen, Yulia Monakhova
Several unconnected laboratory experiments are usually offered for students in instrumental analysis lab. To give the students a more rational overview of the most common instrumental techniques, a new laboratory experiment was developed. Marketed pain relief drugs, familiar consumer products with one to three active components, namely, acetaminophen (paracetamol), acetylsalicylic acid (ASA), and caffeine, were selected. Common analytical methods were compared regarding the performance of qualitative and quantitative analysis of unknown tablets: UV–visible (UV–vis), infrared (IR), and nuclear magnetic resonance (NMR) spectroscopies, as well as high-performance liquid chromatography (HPLC). The students successfully uncovered the composition of formulations, which were divided into three difficulty categories. Students were shown that in addition to simple mixtures handled in theoretical classes, the composition of complex drug products can also be uncovered. By comparing the performance of different techniques, students deepen their understanding and compare the efficiency of analytical methods in the context of complex mixtures. The laboratory experiment can be adjusted for graduate level by including extra tasks such as method optimization, validation, and 2D spectroscopic techniques.
仪器分析实验室通常为学生提供几个互不关联的实验。为了让学生更合理地了解最常用的仪器技术,我们开发了一个新的实验。实验选取了市场上销售的止痛药,也就是我们熟悉的消费品,其中含有一至三种有效成分,即对乙酰氨基酚(扑热息痛)、乙酰水杨酸(ASA)和咖啡因。比较了常用分析方法对未知药片进行定性和定量分析的性能:这些分析方法包括紫外-可见光谱法(UV-vis)、红外光谱法(IR)、核磁共振光谱法(NMR)以及高效液相色谱法(HPLC)。学生们成功地揭示了配方的组成,这些配方分为三个难度类别。学生们了解到,除了理论课上处理过的简单混合物,复杂药物产品的成分也可以揭示出来。通过比较不同技术的性能,学生加深了对复杂混合物的理解,并比较了分析方法的效率。实验室实验可根据研究生水平进行调整,加入方法优化、验证和二维光谱技术等额外任务。
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引用次数: 0
Breaking the Access to Education Barrier: Enhancing HPLC Learning with Virtual Reality 打破教育障碍:利用虚拟现实技术加强高效液相色谱学习
IF 3 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-19 DOI: 10.1021/acs.jchemed.4c00540
Mae Taylor, Nazrul Bin Abdullah, Ayah Al-Dargazelli, Mireia Benito Montaner, Fatma Kareem, Amy Locks, Zijing Cao, Benjamin Bowles, Jean Charles Sarraf, Tamara Fajinmi, Zaid Muwaffak, Cory Beckwith, Gary N. Parkinson, Zoë A. E. Waller, Blanka R. Szulc, Stephen T. Hilton
This research focuses on an innovative approach to the practical teaching of High Performance Liquid Chromatography (HPLC), specifically exploring the application of Virtual Reality (VR) in undergraduate education. Traditionally, the exposure to HPLC instrumentation for undergraduates has been limited due to a substantial student population and the prohibitively high costs of these systems. To overcome these challenges, we developed our own in-house multi-user VR software, as well as a VR digital twin model of HPLC instruments in our laboratory and placed multiple copies of these in a training environment, aiming to simulate a realistic, interactive, and immersive learning HPLC environment. The investigation of its effectiveness included a group of first year undergraduate students with no previous HPLC experience, aiming to assess the reception of the VR learning environment among a student cohort. The use of the VR software positively influenced student engagement with HPLC training. Survey results indicate that the majority of students greatly enjoyed the VR sessions, with many students reporting a heightened interest in practicals and self-reporting that they learned better than they would have using text or PowerPoints, though formal assessment is needed to quantify its impact on learning outcomes. Notably, students reported a heightened confidence in their operational understanding of the instrument and exhibited a more profound grasp of the underlying theoretical concepts. In light of these findings, we propose that VR learning environments equipped with digital twins of laboratory equipment can greatly enhance practical teaching, particularly in areas constrained by equipment accessibility. This work, therefore, offers compelling insights into the potential of VR learning environments in reshaping HPLC practical teaching in undergraduate education.
本研究侧重于高效液相色谱(HPLC)实践教学的创新方法,特别是探索虚拟现实(VR)在本科生教育中的应用。传统上,由于学生人数众多且这些系统的成本过高,本科生接触高效液相色谱仪器的机会有限。为了克服这些挑战,我们开发了自己的内部多用户 VR 软件,以及实验室中 HPLC 仪器的 VR 数字孪生模型,并在培训环境中放置了多个副本,旨在模拟逼真、互动和身临其境的 HPLC 学习环境。对其有效性的调查包括一组以前没有 HPLC 经验的本科一年级学生,目的是评估学生群体对 VR 学习环境的接受程度。VR 软件的使用对学生参与 HPLC 培训产生了积极影响。调查结果显示,大多数学生都非常喜欢 VR 课程,许多学生表示对实际操作的兴趣有所提高,并自称比使用文本或 PowerPoints 学得更好,不过还需要进行正式评估,以量化 VR 对学习成果的影响。值得注意的是,学生们报告说,他们对仪器的操作理解更加自信,对基本理论概念的掌握也更加深刻。鉴于这些发现,我们建议,配备了实验室设备数字孪生体的 VR 学习环境可以大大提高实践教学效果,尤其是在受设备可及性限制的地区。因此,这项工作为 VR 学习环境在重塑本科教育中高效液相色谱实践教学的潜力提供了令人信服的见解。
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引用次数: 0
Evaluation of the Use of a 360° Immersive Visit of the Organic Chemistry Practical Laboratory for Pharmacy Students 对药学专业学生使用有机化学实践实验室 360° 沉浸式参观的评估
IF 3 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-19 DOI: 10.1021/acs.jchemed.4c00264
Amanda Garrido, François Berthaut, Julien Manganoni
We report the implementation of a new pedagogical virtual tool within the Institut des Sciences Pharmaceutiques et Biologiques (ISPB) of Lyon for second-year pharmacy students. This tool provides a 360° immersive visit to the actual chemistry practical laboratory, allowing students to explore the room before attending the practical class in a video game-like fashion. The originality of this tool lies on the variety of pedagogical contents embedded in the 360° visit, such as 2D videos, lightboard videos, and animation videos. Evaluations of this immersive visit on learning, motivation, and autonomy of pharmacy students have been assessed by the students through online feedback. The positive results obtained demonstrated the usefulness of this tool in improving learning and motivation and fostering increased autonomy during practical classes. A more quantitative analysis was employed to examine the effect of watching the video before practical classes on the students’ autonomy level during the practical classes. The statistical test revealed a significant improvement in autonomy for students who watched the video before attending practical classes compared to those who did not. We hope this work will be beneficial to teaching researchers in pharmacy faculties seeking to bring innovation to their teaching methods.
我们报告了里昂制药与生物科学学院(ISPB)为药学专业二年级学生实施的新型虚拟教学工具。该工具可让学生 360 度身临其境地参观实际的化学实践实验室,让学生在上实践课之前以类似视频游戏的方式探索实验室。该工具的独创性在于在 360° 参观中嵌入了各种教学内容,如二维视频、光板视频和动画视频。学生们通过在线反馈评估了这种沉浸式参观对药学专业学生的学习、积极性和自主性的影响。所获得的积极结果表明,这一工具在提高学习效果和积极性以及在实践课上促进自主性方面非常有用。我们采用了更多的定量分析来研究实践课前观看视频对学生在实践课上的自主水平的影响。统计检验显示,与未观看视频的学生相比,在实践课前观看视频的学生在自主性方面有明显提高。我们希望这项工作能对药学院寻求教学方法创新的教学研究人员有所帮助。
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引用次数: 0
Integration of Teaching Laboratory Activities Based on the Valorization of Industrial Waste into Chemical Education to Address the Emerging Sustainable Development Goals 将基于工业废物价值化的教学实验活动纳入化学教育,以实现新的可持续发展目标
IF 3 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-19 DOI: 10.1021/acs.jchemed.4c00729
José Enrique Martín-Alfonso, Remedios Yáñez
The integration of learning strategies based on the valorization of industrial waste into education is crucial for students to raise awareness of climate change causes and to thrive in the emerging circular bioeconomy. An attractive laboratory experiment focused on the production of second generation bioethanol from apple pomace is proposed. With this approach, undergraduate students of technological specialties explore real routes for the valorization of industrial food wastes. The activity allows them to become aware of the current energy outlook, the causes of climate change, and Sustainable Development Goals (SDGs) of the 2030 Agenda. Moreover, the proposal facilitates acquisition of chemical, technological, and mathematical knowledge and incorporation of important skills and competencies in future professional activities. In this way, students will promote social changes that guarantee the protection of the environment and improve the quality of life, in line with the Education for Sustainable Development (ESD).
将基于工业废物价值化的学习策略纳入教育,对于学生提高气候变化原因的认识和在新兴的循环生物经济中茁壮成长至关重要。我们提出了一个有吸引力的实验室实验,重点是利用苹果渣生产第二代生物乙醇。通过这种方法,技术专业的本科生可以探索工业食品废料价值化的真正途径。通过这项活动,他们可以了解当前的能源前景、气候变化的原因以及 2030 年议程的可持续发展目标(SDGs)。此外,该提案还有助于学习化学、技术和数学知识,并将重要的技能和能力融入未来的职业活动中。通过这种方式,学生将根据可持续发展教育(ESD)促进社会变革,以确保保护环境和提高生活质量。
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引用次数: 0
Application of Specifications Grading to an Analytical Chemistry Lab 将规格分级应用于分析化学实验室
IF 2.5 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-18 DOI: 10.1021/acs.jchemed.4c0078410.1021/acs.jchemed.4c00784
Elizabeth B. Cerkez*, 

Specifications Grading was implemented in a multisection upper-level analytical chemistry laboratory, the first reported for a full lab course redesign in the discipline or in an upper-level chemistry lab class. The primary goals of the redesign were (1) to assess student proficiency of three separate goals: techniques, data quality, and written communication, with three separate assignments, (2) to encourage growth across the semester, providing students the opportunity to show their improvement, and (3) to implement a clear grading system that emphasized equity across the multisection course. Mark distributions on assignments show an increase in students earning exemplary marks on first attempts as the semester progressed, indicating improvement not only within assignments but also across assignments. Student feedback surveys indicate high satisfaction with the grading scheme, with over 72% of survey respondents indicating they would like the grading scheme applied to other courses. Additionally, survey results demonstrate success in achieving the three goals, with students able to articulate the benefits associated with the priorities of the course structure. A particular focus was on the actionability and timeliness of instructor feedback, a hallmark of specifications grading, which students also highly rated. Teaching Assistant feedback indicated that, despite more time spent on grading, teaching satisfaction was higher compared to other courses. The use of regular student feedback to improve the course design is also discussed.

在多节高年级分析化学实验室中实施了 "规范评分",这是在本学科或高年级化学实验课中首次报道对实验课程进行全面重新设计。重新设计的主要目标是:(1) 通过三项独立的作业,评估学生对技术、数据质量和书面交流这三项独立目标的掌握程度;(2) 鼓励学生在整个学期中取得进步,为学生提供展示自己进步的机会;(3) 实施明确的评分制度,强调多科课程的公平性。作业的分数分布显示,随着学期的进展,第一次尝试就获得模范分数的学生人数有所增加,这表明学生不仅在作业内部,而且在不同作业之间都取得了进步。学生反馈调查显示,学生对评分标准的满意度很高,超过 72% 的调查对象表示希望将评分标准应用到其他课程中。此外,调查结果显示,在实现三个目标方面取得了成功,学生能够清楚地说明与课程结构优先事项相关的益处。一个特别的重点是教师反馈的可操作性和及时性,这是规范评分的一个标志,学生对此也给予了高度评价。助教反馈表明,尽管在评分上花费了更多时间,但与其他课程相比,教学满意度更高。此外,还讨论了如何利用定期的学生反馈来改进课程设计。
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引用次数: 0
MedChem Game: Gamification of Drug Design MedChem 游戏:药物设计游戏化
IF 3 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-18 DOI: 10.1021/acs.jchemed.4c00253
Tomasz Danel, Jan Łȩski, Sabina Podlewska, Igor T. Podolak
The growing importance of computer methods in drug discovery encourages greater accessibility of cheminformatics tools. The methods that enable automated analysis of molecules, e.g., molecular docking or machine learning models, remain out of reach for nonexpert computer users. To address the shortage of easily accessible tools that can be used to practice drug design, we created MedChem Game, an Android application that uses gamification and artificial intelligence to help users learn about medicinal chemistry and design new small-molecule drugs. Our application includes a simplified molecule drawing tool used to propose new drug candidates that can be docked to one of the four target proteins currently implemented in the game. Additionally, we have implemented a 3D ligand–protein viewer so that players can inspect molecular docking results. All the designed compounds are stored in a database with the sequence of operations the user performs. The key component of our system is a continuously trained deep generative model that utilizes user-developed compounds to improve the quality of generated molecules. Learning directly from the expertise and creativity of players, including medicinal chemists, could help advance computer-aided drug design in the future. Moreover, MedChem Game could be a useful supplement to courses on small-molecule drug design.
计算机方法在药物发现中的重要性与日俱增,这促使人们更容易获得化学信息学工具。对于非专业计算机用户来说,分子对接或机器学习模型等实现分子自动分析的方法仍然遥不可及。为了解决缺乏可用于药物设计实践的易用工具的问题,我们创建了 MedChem Game,这是一款安卓应用程序,利用游戏化和人工智能帮助用户学习药物化学知识并设计新的小分子药物。我们的应用程序包括一个简化的分子绘制工具,用于提出新的候选药物,这些候选药物可以与游戏中目前实现的四个目标蛋白质之一对接。此外,我们还提供了一个三维配体-蛋白质查看器,以便玩家查看分子对接结果。所有设计的化合物都存储在一个数据库中,其中包含用户执行的操作序列。我们系统的关键组成部分是一个持续训练的深度生成模型,它利用用户开发的化合物来提高生成分子的质量。直接从玩家(包括药物化学家)的专业知识和创造力中学习,有助于推进未来的计算机辅助药物设计。此外,MedChem Game 可以作为小分子药物设计课程的有益补充。
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引用次数: 0
Inquiry-Based Experiments with No-Mess Markers 使用无痕标记进行探究式实验
IF 2.5 3区 教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-18 DOI: 10.1021/acs.jchemed.4c0091910.1021/acs.jchemed.4c00919
Thomas S. Kuntzleman*, Joshua B. Kenney and Melissa Hemling, 

A previous article in this Journal focuses on “No-Mess” coloring products that utilize the chemical reaction between colorless leuco dyes and zinc ions, which act as Lewis acids ( J. Chem. Educ. 2022, 99 (6), 2364−2371). This reaction causes the leuco dyes to become colored. There are two main types of No-Mess marking systems. The first type includes markers containing leuco dyes that become colored upon contact with zinc ions embedded in marking paper. In the second type, the system is reversed. The markers contain zinc ions that activate leuco dyes embedded in the paper. These products offer new opportunities for guided and open inquiry-based investigations. This paper reports that solutions of zinc ions develop the color of leuco marker dyes to a degree comparable with commercial systems. While solutions of other metal ions also induce this color change, they do so to a lesser extent. Therefore, using zinc ion solutions allows for experiments and demonstrations with No-Mess marking products to be more visually stimulating than those previously reported.

本期刊之前的一篇文章重点介绍了利用无色白兰地染料和锌离子(锌离子是路易斯酸)之间的化学反应制成的 "无残留 "着色产品(《化学教育杂志》,2022 年,99(6),2364-237)。2022,99 (6),2364-2371)。这种反应会使白基染料变色。无残留标记系统主要有两种类型。第一种类型包括含有白兰地染料的记号笔,这些染料与嵌入记号笔纸中的锌离子接触后会着色。第二种系统则相反。标记纸含有锌离子,可激活嵌入标记纸中的白兰地染料。这些产品为引导式探究和开放式探究提供了新的机会。本文报告说,锌离子溶液能使亮光标记染料显色,其程度可与商业系统媲美。虽然其他金属离子的溶液也会引起这种颜色变化,但程度较低。因此,与以前的报告相比,使用锌离子溶液可以使 "无痕标记 "产品的实验和演示更具视觉刺激性。
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引用次数: 0
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Journal of Chemical Education
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