Pub Date : 2026-01-01DOI: 10.1016/j.ultsonch.2025.107731
Qiqing Chen , Lin Xie , Yangcheng Yao , Qiang Zhou , Yan Lin , Dandan Sun , Zhuole Wu , Dong Xie , Xiangxiang Jing
Sonodynamic therapy (SDT) faces significant challenges in treating aggressive malignancies due to inherent apoptotic resistance. To address this, we developed a multifunctional nanoliposome designed for mitochondrial targeting and synergistic induction of dual cell death pathways. Co-loaded with the sonosensitizer HMME and an iron-based Fenton catalyst, the nanoparticle exhibits glutathione-responsive disassembly and promotes robust reactive oxygen species generation under ultrasound irradiation. This leads to potent lipid peroxidation and ferroptosis, effectively bypassing conventional resistance mechanisms. The platform further integrates dual-modal magnetic resonance and photoacoustic imaging capabilities, enabling precise tumor delineation and real-time treatment monitoring. Constructed entirely from clinically approved lipid components, our nanoplatform demonstrates excellent biocompatibility and achieves complete tumor regression in murine models without significant systemic toxicity. This work provides a comprehensive theranostic strategy that combines catalytic amplification with multimodal imaging, offering a clinically translatable approach for the precision treatment of therapy-resistant malignancies.
{"title":"Ultrasound-Propelled ferroptosis catalytic amplification for Active-targeting sonodynamic anti-tumor therapy with Concurrent Photoacoustic/MRI visualization","authors":"Qiqing Chen , Lin Xie , Yangcheng Yao , Qiang Zhou , Yan Lin , Dandan Sun , Zhuole Wu , Dong Xie , Xiangxiang Jing","doi":"10.1016/j.ultsonch.2025.107731","DOIUrl":"10.1016/j.ultsonch.2025.107731","url":null,"abstract":"<div><div>Sonodynamic therapy (SDT) faces significant challenges in treating aggressive malignancies due to inherent apoptotic resistance. To address this, we developed a multifunctional nanoliposome designed for mitochondrial targeting and synergistic induction of dual cell death pathways. Co-loaded with the sonosensitizer HMME and an iron-based Fenton catalyst, the nanoparticle exhibits glutathione-responsive disassembly and promotes robust reactive oxygen species generation under ultrasound irradiation. This leads to potent lipid peroxidation and ferroptosis, effectively bypassing conventional resistance mechanisms. The platform further integrates dual-modal magnetic resonance and photoacoustic imaging capabilities, enabling precise tumor delineation and real-time treatment monitoring. Constructed entirely from clinically approved lipid components, our nanoplatform demonstrates excellent biocompatibility and achieves complete tumor regression in murine models without significant systemic toxicity. This work provides a comprehensive theranostic strategy that combines catalytic amplification with multimodal imaging, offering a clinically translatable approach for the precision treatment of therapy-resistant malignancies.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107731"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145813977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.ultsonch.2025.107728
Jiahui Chen , Xinglian Xu
This study systematically investigated the unique effects of ultrasound-assisted EGCG treatment on the amino acids and digestive peptides contents of chicken breast paste. As a complex system, chicken samples exhibited distinct ultrasonic responses that cannot be extrapolated from simplified protein-based studies. To be specific, results demonstrated that ultrasound-assisted EGCG treatment significantly enhanced the essential/non-essential amino acids ratio to 41.03%, which could not be acquired through individual treatment. More so, structural analysis of meat pastes revealed that particle size was reduced by 62.72% after treatment. Furthermore, ultrasound-assisted EGCG treatment reduced total water contents by 13.65%, thereby promoting the transition of immobilized to free water. The above-mentioned changes enhanced enzymatic accessibility and increased peptide contents by 2.18%. This study innovatively highlighted the efficiency of ultrasonic-assisted EGCG treatment in enhancing nutritional features at the level of chicken matrix, offering an important advancement from theory to practice.
{"title":"Improving amino acids and digestive peptides contents of chicken breast paste using ultrasound-assisted EGCG treatment within a complex meat matrix","authors":"Jiahui Chen , Xinglian Xu","doi":"10.1016/j.ultsonch.2025.107728","DOIUrl":"10.1016/j.ultsonch.2025.107728","url":null,"abstract":"<div><div>This study systematically investigated the unique effects of ultrasound-assisted EGCG treatment on the amino acids and digestive peptides contents of chicken breast paste. As a complex system, chicken samples exhibited distinct ultrasonic responses that cannot be extrapolated from simplified protein-based studies. To be specific, results demonstrated that ultrasound-assisted EGCG treatment significantly enhanced the essential/non-essential amino acids ratio to 41.03%, which could not be acquired through individual treatment. More so, structural analysis of meat pastes revealed that particle size was reduced by 62.72% after treatment. Furthermore, ultrasound-assisted EGCG treatment reduced total water contents by 13.65%, thereby promoting the transition of immobilized to free water. The above-mentioned changes enhanced enzymatic accessibility and increased peptide contents by 2.18%. This study innovatively highlighted the efficiency of ultrasonic-assisted EGCG treatment in enhancing nutritional features at the level of chicken matrix, offering an important advancement from theory to practice.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107728"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145785407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.ultsonch.2025.107735
Shengjie Duan , Huiqing Luo , Lihui Yu , Jinya Dong , Ziqian Qiao , Shan Liu , Yanan Li , Huajie Yin , Rui Zhou , Yuanfeng Chen , Siyu Zhou , Chen Gong , Yan Shen , Zezhu Du , Li Feng , Xiaocui Du , Jun Sheng , Ruijuan Yang , Chongye Fang
Pu’erh tea (Camellia sinensis var. assamica) represents a highly complex multiphase fermentation system in which flavor formation spans chemical transformation, energy transfer and microecological succession. To elucidate the mechanistic basis by which sonochemical energy input accelerates flavor evolution, we developed an integrated multiscale model combining flavoromics, molecular dynamics simulations and microbial ecological analysis. The model captures molecular reactions and metabolic regulation under ultrasonic cavitation.Increasing acoustic power density (0.3–0.8 W mL−1) substantially enhanced cavitation intensity and energy absorption, accompanied by elevated concentrations of reactive radicals (•OH 40–96 µM) and an increased mass-transfer coefficient, generating high-energy heterogeneous microdomains. Sonochemical coupling reduced the reaction barrier of ester-type catechins (ΔG ≈ –25 kJ mol−1) and accelerated their conversion into free acid polyphenols. Concurrently, high shear forces induced partial depolymerization of proteins and peptides, leading to 1.5–3-fold increases in taste-active amino acids and soluble sugars, thus reinforcing the “mellow” and “sweet” mouthfeel of the infusion.Microecological (meta-omics) profiling revealed that elevated acoustic energy favored the enrichment of functional microbial consortia dominated by Lactobacillus plantarum and Aspergillus niger. Pathways related to aroma synthesis—including phenylalanine metabolism and monoterpene biosynthesis—exhibited approximately twofold enrichment, driving the accumulation of aromatic esters and terpenes. Multivariate modeling (PLSR and RDA, R2 > 0.90, Q2 > 0.70) confirmed that acoustic power and cavitation indices quantitatively predict flavor outputs. However, rigorous techno-economic analysis and acoustic propagation modeling in solid-state media reveal that industrial scaling faces challenges regarding energy consumption, reactor design for solid–liquid mixtures, and downstream dewatering costs. While the optimal window of 0.6–0.75 W·mL−1 reproducibly generated complex aromatic profiles comparable to aged tea, these engineering constraints necessitate further optimization for commercial viability. Collectively, these findings elucidate the cross-scale mechanism by which coupled sonochemical energy drives flavor evolution and define the application boundaries for green, energy-precise processing of fermented beverages.
普洱茶（Camellia sinensis var. assamica）是一个高度复杂的多相发酵系统，其风味形成跨越了化学转化、能量传递和微生态演替。为了阐明声化学能量输入加速风味进化的机制基础，我们建立了一个结合风味组学、分子动力学模拟和微生物生态学分析的集成多尺度模型。该模型捕捉了超声空化作用下的分子反应和代谢调节。提高声功率密度（0.3-0.8 W mL−1）可显著增强空化强度和能量吸收，同时提高反应自由基浓度（•OH 40-96µM）和传质系数，产生高能非均质微畴。声化学偶联降低了酯型儿茶素的反应屏障（ΔG≈-25 kJ mol−1），加速了它们向游离酸多酚的转化。同时，高剪切力诱导蛋白质和肽的部分解聚，导致味觉活性氨基酸和可溶性糖增加1.5 - 3倍，从而增强了冲剂的“醇厚”和“甜”口感。微生态（元组学）分析显示，声能升高有利于以植物乳杆菌和黑曲霉为主的功能性微生物群落的富集。与芳香合成相关的途径——包括苯丙氨酸代谢和单萜烯生物合成——表现出大约两倍的富集，驱动芳香酯和萜烯的积累。多变量模型（PLSR和RDA， R2 > 0.90, Q2 > 0.70）证实声功率和空化指标定量预测风味输出。然而，严格的技术经济分析和固态介质中的声波传播模型表明，工业规模化面临着能源消耗、固液混合物反应器设计和下游脱水成本等方面的挑战。虽然0.6-0.75 W·mL−1的最佳窗口可重复生成与陈年茶相当的复杂芳香谱，但这些工程限制需要进一步优化以实现商业可行性。总的来说，这些发现阐明了耦合声化学能驱动风味进化的跨尺度机制，并定义了绿色、能量精确加工发酵饮料的应用边界。
{"title":"Multiscale mechanistic insights into sonochemical energy coupling and flavor evolution in Pu‑erh tea","authors":"Shengjie Duan , Huiqing Luo , Lihui Yu , Jinya Dong , Ziqian Qiao , Shan Liu , Yanan Li , Huajie Yin , Rui Zhou , Yuanfeng Chen , Siyu Zhou , Chen Gong , Yan Shen , Zezhu Du , Li Feng , Xiaocui Du , Jun Sheng , Ruijuan Yang , Chongye Fang","doi":"10.1016/j.ultsonch.2025.107735","DOIUrl":"10.1016/j.ultsonch.2025.107735","url":null,"abstract":"<div><div>Pu’erh tea (<em>Camellia sinensis</em> var. <em>assamica</em>) represents a highly complex multiphase fermentation system in which flavor formation spans chemical transformation, energy transfer and microecological succession. To elucidate the mechanistic basis by which sonochemical energy input accelerates flavor evolution, we developed an integrated multiscale model combining flavoromics, molecular dynamics simulations and microbial ecological analysis. The model captures molecular reactions and metabolic regulation under ultrasonic cavitation.Increasing acoustic power density (0.3–0.8 W mL<sup>−1</sup>) substantially enhanced cavitation intensity and energy absorption, accompanied by elevated concentrations of reactive radicals (•OH 40–96 µM) and an increased mass-transfer coefficient, generating high-energy heterogeneous microdomains. Sonochemical coupling reduced the reaction barrier of ester-type catechins (ΔG ≈ –25 kJ mol<sup>−1</sup>) and accelerated their conversion into free acid polyphenols. Concurrently, high shear forces induced partial depolymerization of proteins and peptides, leading to 1.5–3-fold increases in taste-active amino acids and soluble sugars, thus reinforcing the “<em>mellow</em>” and “<em>sweet</em>” mouthfeel of the infusion.Microecological (<em>meta</em>-omics) profiling revealed that elevated acoustic energy favored the enrichment of functional microbial consortia dominated by <em>Lactobacillus plantarum</em> and <em>Aspergillus niger</em>. Pathways related to aroma synthesis—including phenylalanine metabolism and monoterpene biosynthesis—exhibited approximately twofold enrichment, driving the accumulation of aromatic esters and terpenes. Multivariate modeling (PLSR and RDA, R<sup>2</sup> > 0.90, Q<sup>2</sup> > 0.70) confirmed that acoustic power and cavitation indices quantitatively predict flavor outputs. However, rigorous techno-economic analysis and acoustic propagation modeling in solid-state media reveal that industrial scaling faces challenges regarding energy consumption, reactor design for solid–liquid mixtures, and downstream dewatering costs. While the optimal window of 0.6–0.75 W·mL<sup>−1</sup> reproducibly generated complex aromatic profiles comparable to aged tea, these engineering constraints necessitate further optimization for commercial viability. Collectively, these findings elucidate the cross-scale mechanism by which coupled sonochemical energy drives flavor evolution and define the application boundaries for green, energy-precise processing of fermented beverages.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"125 ","pages":"Article 107735"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.ultsonch.2025.107729
Liang Ye , Yixin Pan , Wenfang Wang , Shixin Li , Bing Yang , Xiaobin Jia , Liang Feng
This study aimed to developed an integrated ultrasound-assisted approach that incorporates ultrasound into both the enzymatic biotransformation and resin-based purification steps for the efficient preparation of secondary flavonoid glycosides (SFGs) from Epimedium. Ultrasound pretreatment was first applied to cellulase to enhance the deglycosylation of parent flavonoid glycosides (PFGs), followed by ultrasound-assisted purification using ADS-17 resin, while kinetic modeling, adsorption–desorption profiling, and morphological examinations were conducted to elucidate the underlying mechanisms of ultrasonic intensification. Kinetic analysis showed that ultrasonic pretreatment (50 W) significantly accelerated the enzymatic reaction, increasing the first-order rate constant (k1 from 0.0129 to 0.0287 min–1) and reducing the time to 99 % conversion (t99) from 356 to 161 min. During purification, pseudo-second-order kinetic modeling confirmed that ultrasound (150 W) enhanced adsorption by increasing the rate constant and raising the equilibrium capacity from 77.58 to 99.06 mg/g, while pseudo-first-order modeling described the accelerated desorption process, in which t95 was shortened by ∼ 40 %. The purified SFGs achieved > 80 % purity as verified by UPLC–Q–TOF–MS. In ovariectomized rats, ultrasound-prepared SFGs markedly improved trabecular microarchitecture, biochemical markers, and OPG/RANKL/RANK signaling, exhibiting superior anti-osteoporotic efficacy compared with crude PFGs. Overall, this work develops a dual-stage ultrasound-intensified strategy that integrates biotransformation with resin purification, providing a green, efficient, and scalable approach for producing high-value natural flavonoids.
{"title":"A sonochemical strategy integrating enzymatic conversion and purification for efficient production of secondary flavonoid glycosides from Epimedium","authors":"Liang Ye , Yixin Pan , Wenfang Wang , Shixin Li , Bing Yang , Xiaobin Jia , Liang Feng","doi":"10.1016/j.ultsonch.2025.107729","DOIUrl":"10.1016/j.ultsonch.2025.107729","url":null,"abstract":"<div><div>This study aimed to developed an integrated ultrasound-assisted approach that incorporates ultrasound into both the enzymatic biotransformation and resin-based purification steps for the efficient preparation of secondary flavonoid glycosides (SFGs) from Epimedium. Ultrasound pretreatment was first applied to cellulase to enhance the deglycosylation of parent flavonoid glycosides (PFGs), followed by ultrasound-assisted purification using ADS-17 resin, while kinetic modeling, adsorption–desorption profiling, and morphological examinations were conducted to elucidate the underlying mechanisms of ultrasonic intensification. Kinetic analysis showed that ultrasonic pretreatment (50 W) significantly accelerated the enzymatic reaction, increasing the first-order rate constant (k<sub>1</sub> from 0.0129 to 0.0287 min<sup>–1</sup>) and reducing the time to 99 % conversion (t<sub>99</sub>) from 356 to 161 min. During purification, pseudo-second-order kinetic modeling confirmed that ultrasound (150 W) enhanced adsorption by increasing the rate constant and raising the equilibrium capacity from 77.58 to 99.06 mg/g, while pseudo-first-order modeling described the accelerated desorption process, in which t<sub>95</sub> was shortened by ∼ 40 %. The purified SFGs achieved > 80 % purity as verified by UPLC–Q–TOF–MS. In ovariectomized rats, ultrasound-prepared SFGs markedly improved trabecular microarchitecture, biochemical markers, and OPG/RANKL/RANK signaling, exhibiting superior anti-osteoporotic efficacy compared with crude PFGs. Overall, this work develops a dual-stage ultrasound-intensified strategy that integrates biotransformation with resin purification, providing a green, efficient, and scalable approach for producing high-value natural flavonoids.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"125 ","pages":"Article 107729"},"PeriodicalIF":9.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-27DOI: 10.1016/j.ultsonch.2025.107732
Pengbo Wu , Shuaihui Sun , Pengcheng Guo , Haipeng Nan , Tao Wang , Xuezheng Zheng
This study systematically investigated the cavitation erosion resistance and failure mechanisms of 06Cr13Ni5Mo(S135) stainless steel and four coatings (HVOF-WC10Co4Cr, HVOF-Cr3C237WC18, HVAF-WC10Co4Cr, Laser-Clad(LC)) using ultrasonic cavitation testing. The cavitation weight losses of the HVOF-WC10Co4Cr, HVAF-WC10Co4Cr, HVOF-Cr3C237WC18, and LC coatings were 1.58, 0.88, 0.91, and 0.34 times that of the S135 stainless-steel substrate, respectively. Their surface roughness values were 5.43, 3.48, 2.30, and 0.56 times that of the substrate. Among the four coatings, the LC coating showed the lowest weight loss and the smallest roughness increase. The HVOF-WC10Co4Cr coating exhibited the poorest cavitation erosion resistance despite having the highest microhardness, which indicated that high hardness alone did not ensure superior performance. For the thermal spray coatings, pre-existing pores served as the primary initiation sites for damage. Fatigue cracks nucleated at these pores and propagated along inter-splat boundaries, leading to spallation. The HVAF-WC10Co4Cr coating, with 29% lower porosity than its HVOF counterpart, demonstrated significantly enhanced resistance. The LC coating had a unique lamellar stacking structure that effectively confined damage to the surface. However, the through-thickness cracks caused by process defects accelerated local delamination and resulted in funnel-shaped pits. These findings provide critical insights into the design and selection of cavitation-resistant coatings for hydraulic turbines.
{"title":"Cavitation erosion characteristics and mechanisms of hydraulic turbine substrates and their coatings","authors":"Pengbo Wu , Shuaihui Sun , Pengcheng Guo , Haipeng Nan , Tao Wang , Xuezheng Zheng","doi":"10.1016/j.ultsonch.2025.107732","DOIUrl":"10.1016/j.ultsonch.2025.107732","url":null,"abstract":"<div><div>This study systematically investigated the cavitation erosion resistance and failure mechanisms of 06Cr13Ni5Mo(S135) stainless steel and four coatings (HVOF-WC10Co4Cr, HVOF-Cr<sub>3</sub>C<sub>2</sub>37WC18, HVAF-WC10Co4Cr, Laser-Clad(LC)) using ultrasonic cavitation testing. The cavitation weight losses of the HVOF-WC10Co4Cr, HVAF-WC10Co4Cr, HVOF-Cr<sub>3</sub>C<sub>2</sub>37WC18, and LC coatings were 1.58, 0.88, 0.91, and 0.34 times that of the S135 stainless-steel substrate, respectively. Their surface roughness values were 5.43, 3.48, 2.30, and 0.56 times that of the substrate. Among the four coatings, the LC coating showed the lowest weight loss and the smallest roughness increase. The HVOF-WC10Co4Cr coating exhibited the poorest cavitation erosion resistance despite having the highest microhardness, which indicated that high hardness alone did not ensure superior performance. For the thermal spray coatings, pre-existing pores served as the primary initiation sites for damage. Fatigue cracks nucleated at these pores and propagated along inter-splat boundaries, leading to spallation. The HVAF-WC10Co4Cr coating, with 29% lower porosity than its HVOF counterpart, demonstrated significantly enhanced resistance. The LC coating had a unique lamellar stacking structure that effectively confined damage to the surface. However, the through-thickness cracks caused by process defects accelerated local delamination and resulted in funnel-shaped pits. These findings provide critical insights into the design and selection of cavitation-resistant coatings for hydraulic turbines.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"125 ","pages":"Article 107732"},"PeriodicalIF":9.7,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.ultsonch.2025.107726
Woongchan Shim , Ryeol Park , Jaedeok Seo , Wonjung Kim
Efficient removal of oily contaminants from solid surfaces remains a significant challenge in various engineering applications. While ultrasonic cleaning mechanisms for solid particles are well established, the detachment of oil droplets is less understood due to the distinct interfacial and viscous characteristics of oils. Here, we experimentally investigate oil droplet removal under ultrasonic excitation, focusing on the role of cavitation bubble dynamics. High-speed visualizations reveal that cleaning is initiated by bubble penetration into the droplet, followed by successive coalescence and growth of bubbles. This process progressively reduces the droplet–substrate contact area, ultimately resulting in detachment. We identify a critical acoustic pressure threshold above which bubble penetration becomes frequent and cleaning efficiency increases sharply. The results indicate that oil detachment is governed by microjets generated during bubble collapse, which must overcome interfacial resistance for successful penetration. These findings provide mechanistic insight into the ultrasonic removal of oil-based residues and offer practical guidance for enhancing cleaning performance through control of acoustic parameters.
{"title":"Mechanisms of oil droplet detachment by cavitation bubbles in ultrasonic cleaning","authors":"Woongchan Shim , Ryeol Park , Jaedeok Seo , Wonjung Kim","doi":"10.1016/j.ultsonch.2025.107726","DOIUrl":"10.1016/j.ultsonch.2025.107726","url":null,"abstract":"<div><div>Efficient removal of oily contaminants from solid surfaces remains a significant challenge in various engineering applications. While ultrasonic cleaning mechanisms for solid particles are well established, the detachment of oil droplets is less understood due to the distinct interfacial and viscous characteristics of oils. Here, we experimentally investigate oil droplet removal under ultrasonic excitation, focusing on the role of cavitation bubble dynamics. High-speed visualizations reveal that cleaning is initiated by bubble penetration into the droplet, followed by successive coalescence and growth of bubbles. This process progressively reduces the droplet–substrate contact area, ultimately resulting in detachment. We identify a critical acoustic pressure threshold above which bubble penetration becomes frequent and cleaning efficiency increases sharply. The results indicate that oil detachment is governed by microjets generated during bubble collapse, which must overcome interfacial resistance for successful penetration. These findings provide mechanistic insight into the ultrasonic removal of oil-based residues and offer practical guidance for enhancing cleaning performance through control of acoustic parameters.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107726"},"PeriodicalIF":9.7,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultimate oxidation has attracted growing consideration due to its capacity to generate extremely reactive oxidants, such as OH. In particular, Fenton chemistry and ultrasonication (US) techniques have demonstrated significant potential for degrading resistant contaminants in wastewater. The US/Fenton technique involves ultrasonication with Fenton’s reagent to enhance OH radical generation and improve treatment efficacy. This review examines the theoretical foundations, operational effectiveness, and recent developments associated with US/Fenton. First, the report provides an overview of the Fenton, ultrasonication, and US/Fenton mechanisms, both individually and in combination. Then, it analyzes how variables such as ultrasonication frequency, energy input, pH, and reagent dosage influence performance. Next, the discussion turns to novel adaptations, such as US/photo-Fenton and US/electro-Fenton methods, and their roles in sludge treatment and related applications. Lastly, the review addresses the current challenges to its widespread implementation and outlines future research needs. Overall, the review emphasizes the recent progress and promising potential of US/Fenton as a robust wastewater remediation approach.
{"title":"Review of ultrasonication-assisted Fenton processes for degrading aqueous pollutants","authors":"Slimane Merouani , Aissa Dehane , Oualid Hamdaoui , Muthupandian Ashokkumar","doi":"10.1016/j.ultsonch.2025.107725","DOIUrl":"10.1016/j.ultsonch.2025.107725","url":null,"abstract":"<div><div>Ultimate oxidation has attracted growing consideration due to its capacity to generate extremely reactive oxidants, such as <sup><img></sup>OH. In particular, Fenton chemistry and ultrasonication (US) techniques have demonstrated significant potential for degrading resistant contaminants in wastewater. The US/Fenton technique involves ultrasonication with Fenton’s reagent to enhance <sup><img></sup>OH radical generation and improve treatment efficacy. This review examines the theoretical foundations, operational effectiveness, and recent developments associated with US/Fenton. First, the report provides an overview of the Fenton, ultrasonication, and US/Fenton mechanisms, both individually and in combination. Then, it analyzes how variables such as ultrasonication frequency, energy input, pH, and reagent dosage influence performance. Next, the discussion turns to novel adaptations, such as US/photo-Fenton and US/electro-Fenton methods, and their roles in sludge treatment and related applications. Lastly, the review addresses the current challenges to its widespread implementation and outlines future research needs. Overall, the review emphasizes the recent progress and promising potential of US/Fenton as a robust wastewater remediation approach.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107725"},"PeriodicalIF":9.7,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145785408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-14DOI: 10.1016/j.ultsonch.2025.107707
Ali Hamzeh , Lobdaw Saelee , Kanjana Thumanu , Jae W. Park , Jirawat Yongsawatdigul
Ultrasound (US)-assisted single washing was applied to reduce water usage in tilapia mince washing during surimi production. The mince-to-water ratio of 1:2 in US-assisted washing was compared with ratios of 1:2 and 1:3 in conventional washing (CW−2 and CW−3, respectively). Screening of US power revealed the greatest effect at an intensity of 3.19 W/cm2 on mince whiteness (p < 0.05), without damage to protein polypeptide chains, and no extensive biochemical changes. Subsequently, the mince was subjected to various US exposure times of 1, 3, and 5 min (US−1, US−3, and US−5, respectively) at 3.19 W/cm2, maintaining the same total washing time of 10 min across all treatments. US-assisted washing increased myofibrillar protein loss compared with that with CW, as indicated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and the loss increased with longer exposure time—from 7.57 % in US−1 to 12.76 % in US−5. The US−1-washed mince exhibited the highest Ca2+–ATPase activity and reactive sulfhydryl (SH) content, even higher than that of CW−3 (p < 0.05). Random coil structures decreased in US−5, while other secondary structures did not change significantly. Tertiary structure analysis using Raman spectroscopy revealed comparable tyrosine and tryptophan exposure in US−1, US−3, and CW−3, which may contribute to the increased breaking force and distance through higher extent of hydrophobic interactions in their corresponding surimi gels compared with CW−2 and US − 5 (p < 0.05). Oxidation of SH groups and hydrophobic interactions increased in US−3 and US−5 (p < 0.05). US−1 was identified as the optimal condition for a single washing of tilapia mince to reduce water usage with minimal negative effects on protein.
{"title":"Impact of ultrasound-assisted single washing process on tilapia mince: Biochemical changes, structural modifications, and gel formation","authors":"Ali Hamzeh , Lobdaw Saelee , Kanjana Thumanu , Jae W. Park , Jirawat Yongsawatdigul","doi":"10.1016/j.ultsonch.2025.107707","DOIUrl":"10.1016/j.ultsonch.2025.107707","url":null,"abstract":"<div><div>Ultrasound (US)-assisted single washing was applied to reduce water usage in tilapia mince washing during surimi production. The mince-to-water ratio of 1:2 in US-assisted washing was compared with ratios of 1:2 and 1:3 in conventional washing (CW−2 and CW−3, respectively). Screening of US power revealed the greatest effect at an intensity of 3.19 W/cm<sup>2</sup> on mince whiteness (<em>p</em> < 0.05), without damage to protein polypeptide chains, and no extensive biochemical changes. Subsequently, the mince was subjected to various US exposure times of 1, 3, and 5 min (US−1, US−3, and US−5, respectively) at 3.19 W/cm<sup>2</sup>, maintaining the same total washing time of 10 min across all treatments. US-assisted washing increased myofibrillar protein loss compared with that with CW, as indicated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and the loss increased with longer exposure time—from 7.57 % in US−1 to 12.76 % in US−5. The US−1-washed mince exhibited the highest Ca<sup>2+</sup>–ATPase activity and reactive sulfhydryl (SH) content, even higher than that of CW−3 (<em>p</em> < 0.05). Random coil structures decreased in US−5, while other secondary structures did not change significantly. Tertiary structure analysis using Raman spectroscopy revealed comparable tyrosine and tryptophan exposure in US−1, US−3, and CW−3, which may contribute to the increased breaking force and distance through higher extent of hydrophobic interactions in their corresponding surimi gels compared with CW−2 and US − 5 (<em>p</em> < 0.05). Oxidation of SH groups and hydrophobic interactions increased in US−3 and US−5 (<em>p</em> < 0.05). US−1 was identified as the optimal condition for a single washing of tilapia mince to reduce water usage with minimal negative effects on protein.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107707"},"PeriodicalIF":9.7,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1016/j.ultsonch.2025.107723
Xia Gao , Meng Gui , Gang Yu , Yongqiang Zhao , Liang Gao , Ru Liu
This study investigated the differential responses of fish transglutaminase (FTGase) and microbial transglutaminase (MTGase) to NaCl concentrations and high intensity ultrasound (HIU) during myosin cross-linking. Increasing NaCl concentrations enhanced MTGase activity by 34.5% at 0.8 mol/L compared to the control without NaCl. This enhancement was accompanied by structural unfolding, as evidenced by increased UV absorption intensity, which indicated greater exposure of aromatic residues. In contrast, FTGase activity progressively declined with increasing NaCl concentrations, with minimal structural changes observed. Given its Ca2+-independent property, MTGase was used to explore the synergistic effect of HIU and NaCl. The combination of 400 W HIU and 0.3 mol/L NaCl induced the most pronounced structural changes in MTGase, which exposed some buried reactive sulfhydryl groups and elevated activity by 17.0%. Furthermore, HIU pretreatment of both enzymes enhanced their catalytic efficiency for myosin cross-linking, as evidenced by increased formation of ε-(γ-Glu)-Lys isopeptide bonds. Notably, while HIU-pretreated FTGase improved the water holding capacity (WHC) of myosin samples, HIU-pretreated MTGase likely induced excessive cross-linking, which paradoxically reduced WHC. Conversely, applying HIU directly to preformed enzyme-myosin complexes disrupted established cross-links. These findings provide a basis for optimizing transglutaminase applications in food processing using HIU.
本研究研究了肌球蛋白交联过程中鱼类谷氨酰胺转酶（FTGase）和微生物谷氨酰胺转酶（mtase）对NaCl浓度和高强度超声（HIU）的差异反应。当NaCl浓度为0.8 mol/L时，与不添加NaCl的对照相比，增加NaCl浓度可使mtase活性提高34.5% %，并伴随结构展开，表明芳香残基暴露程度增加。相反，随着NaCl浓度的增加，FTGase活性逐渐下降，结构变化很小。考虑到mtase对Ca2+的依赖性，我们利用它来研究HIU和NaCl的协同作用。400 W / HIU和0.3 mol/L NaCl的组合对mtase的结构变化最为显著，暴露了一些埋藏的活性巯基，使活性提高了17.0 %。此外，HIU预处理两种酶都提高了它们对肌球蛋白交联的催化效率，ε-(γ-Glu)- lys异肽键的形成增加。值得注意的是，虽然HIU预处理的FTGase提高了肌球蛋白样品的持水能力（WHC），但HIU预处理的MTGase可能诱导过度交联，从而矛盾地降低了WHC。相反，将HIU直接应用于预形成的酶-肌球蛋白复合物会破坏已建立的交联。研究结果为优化谷氨酰胺转肽类酶在HIU食品加工中的应用提供了依据。
{"title":"Different responses of fish/microbial transglutaminase to salt and ultrasound: Implications for myosin cross-linking","authors":"Xia Gao , Meng Gui , Gang Yu , Yongqiang Zhao , Liang Gao , Ru Liu","doi":"10.1016/j.ultsonch.2025.107723","DOIUrl":"10.1016/j.ultsonch.2025.107723","url":null,"abstract":"<div><div>This study investigated the differential responses of fish transglutaminase (FTGase) and microbial transglutaminase (MTGase) to NaCl concentrations and high intensity ultrasound (HIU) during myosin cross-linking. Increasing NaCl concentrations enhanced MTGase activity by 34.5% at 0.8 mol/L compared to the control without NaCl. This enhancement was accompanied by structural unfolding, as evidenced by increased UV absorption intensity, which indicated greater exposure of aromatic residues. In contrast, FTGase activity progressively declined with increasing NaCl concentrations, with minimal structural changes observed. Given its Ca<sup>2+</sup>-independent property, MTGase was used to explore the synergistic effect of HIU and NaCl. The combination of 400 W HIU and 0.3 mol/L NaCl induced the most pronounced structural changes in MTGase, which exposed some buried reactive sulfhydryl groups and elevated activity by 17.0%. Furthermore, HIU pretreatment of both enzymes enhanced their catalytic efficiency for myosin cross-linking, as evidenced by increased formation of ε-(γ-Glu)-Lys isopeptide bonds. Notably, while HIU-pretreated FTGase improved the water holding capacity (WHC) of myosin samples, HIU-pretreated MTGase likely induced excessive cross-linking, which paradoxically reduced WHC. Conversely, applying HIU directly to preformed enzyme-myosin complexes disrupted established cross-links. These findings provide a basis for optimizing transglutaminase applications in food processing using HIU.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107723"},"PeriodicalIF":9.7,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pomegranate (Punica granatum L.) peel and seeds are rich in phenolics, flavonoids, anthocyanins, ellagitannins, tannins, and punicic acid, which exhibit potent antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. Conventional extraction methods, such as maceration, Soxhlet extraction, and hydrodistillation, are limited by excessive solvent and energy consumption, prolonged extraction times, and degradation of thermolabile compounds. Ultrasound-assisted extraction (UAE) has emerged as a sustainable and efficient alternative, utilizing acoustic cavitation to disrupt cell walls, enhance solvent penetration, and accelerate mass transfer. This review presents a comprehensive and UAE-specific synthesis of research on pomegranate peel and seed bioactives, focusing on the effect of key parameters ultrasonic power, frequency, extraction time, temperature, solvent system, solid-to-solvent ratio, and particle size on extraction efficiency and compound stability. Optimization strategies based on Response Surface Methodology, Box-Behnken Design, and Artificial Neural Networks are critically discussed to demonstrate their roles in maximizing yield and predicting extraction performance. Structural and spectroscopic studies confirming ultrasound-induced morphological disruption and molecular interactions are also summarized. This review uniquely synthesizes UAE-specific process parameters, optimization models, and structural characterization for both pomegranate peel and seed within a green valorization framework. Comparative analysis highlights the UAE superior performance over conventional and hybrid methods (microwave-, enzyme-, or deep eutectic solvent-assisted extractions). The review also identifies persisting challenges related to process scale-up, standardization of reporting metrics, and in vivo bioavailability assessment. Overall, this work provides an updated framework for improving extraction efficiency and supports the green valorization of pomegranate by-products into functional ingredients for food, nutraceutical, cosmetic, and pharmaceutical industries.
{"title":"Ultrasound-assisted extraction of bioactive compounds from pomegranate peel and seed: A comprehensive review of key parameters and optimization strategies","authors":"Fatima Shehzadi , Muhammad Shoaib , Salman Munir , Gholamreza Abdi","doi":"10.1016/j.ultsonch.2025.107722","DOIUrl":"10.1016/j.ultsonch.2025.107722","url":null,"abstract":"<div><div>Pomegranate (<em>Punica granatum</em> L.) peel and seeds are rich in phenolics, flavonoids, anthocyanins, ellagitannins, tannins, and punicic acid, which exhibit potent antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. Conventional extraction methods, such as maceration, Soxhlet extraction, and hydrodistillation, are limited by excessive solvent and energy consumption, prolonged extraction times, and degradation of thermolabile compounds. Ultrasound-assisted extraction (UAE) has emerged as a sustainable and efficient alternative, utilizing acoustic cavitation to disrupt cell walls, enhance solvent penetration, and accelerate mass transfer. This review presents a comprehensive and UAE-specific synthesis of research on pomegranate peel and seed bioactives, focusing on the effect of key parameters ultrasonic power, frequency, extraction time, temperature, solvent system, solid-to-solvent ratio, and particle size on extraction efficiency and compound stability. Optimization strategies based on Response Surface Methodology, Box-Behnken Design, and Artificial Neural Networks are critically discussed to demonstrate their roles in maximizing yield and predicting extraction performance. Structural and spectroscopic studies confirming ultrasound-induced morphological disruption and molecular interactions are also summarized. This review uniquely synthesizes UAE-specific process parameters, optimization models, and structural characterization for both pomegranate peel and seed within a green valorization framework. Comparative analysis highlights the UAE superior performance over conventional and hybrid methods (microwave-, enzyme-, or deep eutectic solvent-assisted extractions). The review also identifies persisting challenges related to process scale-up, standardization of reporting metrics, and in vivo bioavailability assessment. Overall, this work provides an updated framework for improving extraction efficiency and supports the green valorization of pomegranate by-products into functional ingredients for food, nutraceutical, cosmetic, and pharmaceutical industries.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107722"},"PeriodicalIF":9.7,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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