Ultrasonics Sonochemistry最新文献_第4页

Multiscale mechanistic insights into sonochemical energy coupling and flavor evolution in Pu‑erh tea 普洱茶声化学能耦合与风味演化的多尺度机理研究

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2026-01-01 DOI: 10.1016/j.ultsonch.2025.107735

Shengjie Duan , Huiqing Luo , Lihui Yu , Jinya Dong , Ziqian Qiao , Shan Liu , Yanan Li , Huajie Yin , Rui Zhou , Yuanfeng Chen , Siyu Zhou , Chen Gong , Yan Shen , Zezhu Du , Li Feng , Xiaocui Du , Jun Sheng , Ruijuan Yang , Chongye Fang

Pu’erh tea (Camellia sinensis var. assamica) represents a highly complex multiphase fermentation system in which flavor formation spans chemical transformation, energy transfer and microecological succession. To elucidate the mechanistic basis by which sonochemical energy input accelerates flavor evolution, we developed an integrated multiscale model combining flavoromics, molecular dynamics simulations and microbial ecological analysis. The model captures molecular reactions and metabolic regulation under ultrasonic cavitation.Increasing acoustic power density (0.3–0.8 W mL⁻¹) substantially enhanced cavitation intensity and energy absorption, accompanied by elevated concentrations of reactive radicals (•OH 40–96 µM) and an increased mass-transfer coefficient, generating high-energy heterogeneous microdomains. Sonochemical coupling reduced the reaction barrier of ester-type catechins (ΔG ≈ –25 kJ mol⁻¹) and accelerated their conversion into free acid polyphenols. Concurrently, high shear forces induced partial depolymerization of proteins and peptides, leading to 1.5–3-fold increases in taste-active amino acids and soluble sugars, thus reinforcing the “mellow” and “sweet” mouthfeel of the infusion.Microecological (meta-omics) profiling revealed that elevated acoustic energy favored the enrichment of functional microbial consortia dominated by Lactobacillus plantarum and Aspergillus niger. Pathways related to aroma synthesis—including phenylalanine metabolism and monoterpene biosynthesis—exhibited approximately twofold enrichment, driving the accumulation of aromatic esters and terpenes. Multivariate modeling (PLSR and RDA, R² > 0.90, Q² > 0.70) confirmed that acoustic power and cavitation indices quantitatively predict flavor outputs. However, rigorous techno-economic analysis and acoustic propagation modeling in solid-state media reveal that industrial scaling faces challenges regarding energy consumption, reactor design for solid–liquid mixtures, and downstream dewatering costs. While the optimal window of 0.6–0.75 W·mL⁻¹ reproducibly generated complex aromatic profiles comparable to aged tea, these engineering constraints necessitate further optimization for commercial viability. Collectively, these findings elucidate the cross-scale mechanism by which coupled sonochemical energy drives flavor evolution and define the application boundaries for green, energy-precise processing of fermented beverages.

普洱茶（Camellia sinensis var. assamica）是一个高度复杂的多相发酵系统，其风味形成跨越了化学转化、能量传递和微生态演替。为了阐明声化学能量输入加速风味进化的机制基础，我们建立了一个结合风味组学、分子动力学模拟和微生物生态学分析的集成多尺度模型。该模型捕捉了超声空化作用下的分子反应和代谢调节。提高声功率密度（0.3-0.8 W mL−1）可显著增强空化强度和能量吸收，同时提高反应自由基浓度（•OH 40-96µM）和传质系数，产生高能非均质微畴。声化学偶联降低了酯型儿茶素的反应屏障（ΔG≈-25 kJ mol−1），加速了它们向游离酸多酚的转化。同时，高剪切力诱导蛋白质和肽的部分解聚，导致味觉活性氨基酸和可溶性糖增加1.5 - 3倍，从而增强了冲剂的“醇厚”和“甜”口感。微生态（元组学）分析显示，声能升高有利于以植物乳杆菌和黑曲霉为主的功能性微生物群落的富集。与芳香合成相关的途径——包括苯丙氨酸代谢和单萜烯生物合成——表现出大约两倍的富集，驱动芳香酯和萜烯的积累。多变量模型（PLSR和RDA， R2 > 0.90, Q2 > 0.70）证实声功率和空化指标定量预测风味输出。然而，严格的技术经济分析和固态介质中的声波传播模型表明，工业规模化面临着能源消耗、固液混合物反应器设计和下游脱水成本等方面的挑战。虽然0.6-0.75 W·mL−1的最佳窗口可重复生成与陈年茶相当的复杂芳香谱，但这些工程限制需要进一步优化以实现商业可行性。总的来说，这些发现阐明了耦合声化学能驱动风味进化的跨尺度机制，并定义了绿色、能量精确加工发酵饮料的应用边界。

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引用次数: 0

A sonochemical strategy integrating enzymatic conversion and purification for efficient production of secondary flavonoid glycosides from Epimedium 结合酶转化和纯化的声化学策略高效生产淫羊藿次生黄酮类苷。

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-30 DOI: 10.1016/j.ultsonch.2025.107729

Liang Ye , Yixin Pan , Wenfang Wang , Shixin Li , Bing Yang , Xiaobin Jia , Liang Feng

This study aimed to developed an integrated ultrasound-assisted approach that incorporates ultrasound into both the enzymatic biotransformation and resin-based purification steps for the efficient preparation of secondary flavonoid glycosides (SFGs) from Epimedium. Ultrasound pretreatment was first applied to cellulase to enhance the deglycosylation of parent flavonoid glycosides (PFGs), followed by ultrasound-assisted purification using ADS-17 resin, while kinetic modeling, adsorption–desorption profiling, and morphological examinations were conducted to elucidate the underlying mechanisms of ultrasonic intensification. Kinetic analysis showed that ultrasonic pretreatment (50 W) significantly accelerated the enzymatic reaction, increasing the first-order rate constant (k₁ from 0.0129 to 0.0287 min^–1) and reducing the time to 99 % conversion (t₉₉) from 356 to 161 min. During purification, pseudo-second-order kinetic modeling confirmed that ultrasound (150 W) enhanced adsorption by increasing the rate constant and raising the equilibrium capacity from 77.58 to 99.06 mg/g, while pseudo-first-order modeling described the accelerated desorption process, in which t₉₅ was shortened by ∼ 40 %. The purified SFGs achieved > 80 % purity as verified by UPLC–Q–TOF–MS. In ovariectomized rats, ultrasound-prepared SFGs markedly improved trabecular microarchitecture, biochemical markers, and OPG/RANKL/RANK signaling, exhibiting superior anti-osteoporotic efficacy compared with crude PFGs. Overall, this work develops a dual-stage ultrasound-intensified strategy that integrates biotransformation with resin purification, providing a green, efficient, and scalable approach for producing high-value natural flavonoids.

本研究旨在开发一种综合超声辅助方法，将超声结合到酶促生物转化和树脂基纯化步骤中，以有效地从淫羊藿中制备次生类黄酮苷（SFGs）。首先将超声预处理应用于纤维素酶以增强亲本类黄酮苷（PFGs）的去糖基化，然后使用ADS-17树脂进行超声辅助纯化，同时进行动力学建模，吸附-解吸分析和形态学检查以阐明超声强化的潜在机制。动力学分析表明，超声预处理（50 W）显著加速了酶促反应，提高了一级反应速率常数（k1从0.0129增加到0.0287 min-1），将转化时间从356缩短到161 min。在纯化过程中，伪二级动力学模型证实了超声（150 W）通过提高速率常数和将平衡容量从77.58提高到99.06 mg/g来增强吸附，而伪一级模型描述了加速的脱附过程，其中t95缩短了约40%。经UPLC-Q-TOF-MS验证，纯化后的SFGs纯度达到80 ~ 80%。在去卵巢大鼠中，超声制备的PFGs显著改善了小梁微结构、生化指标和OPG/RANKL/RANK信号，与粗制PFGs相比，显示出更好的抗骨质疏松作用。总的来说，本研究开发了一种双级超声强化策略，将生物转化与树脂纯化相结合，为生产高价值的天然类黄酮提供了一种绿色、高效、可扩展的方法。

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引用次数: 0

Cavitation erosion characteristics and mechanisms of hydraulic turbine substrates and their coatings 水轮机基板及其涂层空蚀特性及机理

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-27 DOI: 10.1016/j.ultsonch.2025.107732

Pengbo Wu , Shuaihui Sun , Pengcheng Guo , Haipeng Nan , Tao Wang , Xuezheng Zheng

This study systematically investigated the cavitation erosion resistance and failure mechanisms of 06Cr13Ni5Mo(S135) stainless steel and four coatings (HVOF-WC10Co4Cr, HVOF-Cr₃C₂37WC18, HVAF-WC10Co4Cr, Laser-Clad(LC)) using ultrasonic cavitation testing. The cavitation weight losses of the HVOF-WC10Co4Cr, HVAF-WC10Co4Cr, HVOF-Cr₃C₂37WC18, and LC coatings were 1.58, 0.88, 0.91, and 0.34 times that of the S135 stainless-steel substrate, respectively. Their surface roughness values were 5.43, 3.48, 2.30, and 0.56 times that of the substrate. Among the four coatings, the LC coating showed the lowest weight loss and the smallest roughness increase. The HVOF-WC10Co4Cr coating exhibited the poorest cavitation erosion resistance despite having the highest microhardness, which indicated that high hardness alone did not ensure superior performance. For the thermal spray coatings, pre-existing pores served as the primary initiation sites for damage. Fatigue cracks nucleated at these pores and propagated along inter-splat boundaries, leading to spallation. The HVAF-WC10Co4Cr coating, with 29% lower porosity than its HVOF counterpart, demonstrated significantly enhanced resistance. The LC coating had a unique lamellar stacking structure that effectively confined damage to the surface. However, the through-thickness cracks caused by process defects accelerated local delamination and resulted in funnel-shaped pits. These findings provide critical insights into the design and selection of cavitation-resistant coatings for hydraulic turbines.

采用超声空化试验系统研究了06Cr13Ni5Mo（S135）不锈钢及其四种涂层（HVOF-WC10Co4Cr、HVOF-Cr3C237WC18、HVAF-WC10Co4Cr、激光熔覆（LC））的抗空化侵蚀性能及失效机理。HVOF-WC10Co4Cr、hvf - wc10co4cr、HVOF-Cr3C237WC18和LC涂层的空化失重分别是S135不锈钢基体的1.58倍、0.88倍、0.91倍和0.34倍。表面粗糙度分别为基体的5.43、3.48、2.30和0.56倍。四种涂层中，LC涂层失重最小，粗糙度增加最小。HVOF-WC10Co4Cr涂层具有最高的显微硬度，但其抗空化侵蚀性能最差，这表明仅靠高硬度并不能保证优异的性能。对于热喷涂涂层，预先存在的孔隙是损伤的主要起始点。疲劳裂纹在这些孔隙处成核并沿片间边界扩展，导致剥落。与HVOF涂层相比，HVAF-WC10Co4Cr涂层的孔隙率降低了29%，并显著增强了涂层的耐蚀性。LC涂层具有独特的层状堆叠结构，有效地限制了表面的损伤。然而，工艺缺陷引起的透厚裂纹加速了局部分层，形成漏斗状凹坑。这些发现为水轮机抗空泡涂层的设计和选择提供了重要的见解。

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引用次数: 0

Mechanisms of oil droplet detachment by cavitation bubbles in ultrasonic cleaning 超声清洗中空化泡脱油机理研究。

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-16 DOI: 10.1016/j.ultsonch.2025.107726

Woongchan Shim , Ryeol Park , Jaedeok Seo , Wonjung Kim

Efficient removal of oily contaminants from solid surfaces remains a significant challenge in various engineering applications. While ultrasonic cleaning mechanisms for solid particles are well established, the detachment of oil droplets is less understood due to the distinct interfacial and viscous characteristics of oils. Here, we experimentally investigate oil droplet removal under ultrasonic excitation, focusing on the role of cavitation bubble dynamics. High-speed visualizations reveal that cleaning is initiated by bubble penetration into the droplet, followed by successive coalescence and growth of bubbles. This process progressively reduces the droplet–substrate contact area, ultimately resulting in detachment. We identify a critical acoustic pressure threshold above which bubble penetration becomes frequent and cleaning efficiency increases sharply. The results indicate that oil detachment is governed by microjets generated during bubble collapse, which must overcome interfacial resistance for successful penetration. These findings provide mechanistic insight into the ultrasonic removal of oil-based residues and offer practical guidance for enhancing cleaning performance through control of acoustic parameters.

在各种工程应用中，有效去除固体表面的油性污染物仍然是一个重大挑战。虽然固体颗粒的超声波清洗机制已经很好地建立，但由于油的独特界面和粘性特性，人们对油滴的分离知之甚少。本文通过实验研究了超声激励下的油滴去除，重点研究了空化气泡动力学的作用。高速可视化显示，清洁是由气泡渗透到液滴中开始的，随后是气泡的连续合并和生长。这一过程逐渐减少液滴与衬底的接触面积，最终导致剥离。我们确定了一个临界声压阈值，超过这个阈值，气泡渗透变得频繁，清洗效率急剧提高。结果表明，油的脱离受气泡破裂过程中产生的微射流控制，微射流必须克服界面阻力才能成功渗透。这些发现为超声波去除油基残留物提供了机理见解，并为通过控制声学参数来提高清洗性能提供了实践指导。

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引用次数: 0

Review of ultrasonication-assisted Fenton processes for degrading aqueous pollutants 超声辅助Fenton法降解水中污染物的研究进展

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-16 DOI: 10.1016/j.ultsonch.2025.107725

Slimane Merouani , Aissa Dehane , Oualid Hamdaoui , Muthupandian Ashokkumar

Ultimate oxidation has attracted growing consideration due to its capacity to generate extremely reactive oxidants, such as OH. In particular, Fenton chemistry and ultrasonication (US) techniques have demonstrated significant potential for degrading resistant contaminants in wastewater. The US/Fenton technique involves ultrasonication with Fenton’s reagent to enhance OH radical generation and improve treatment efficacy. This review examines the theoretical foundations, operational effectiveness, and recent developments associated with US/Fenton. First, the report provides an overview of the Fenton, ultrasonication, and US/Fenton mechanisms, both individually and in combination. Then, it analyzes how variables such as ultrasonication frequency, energy input, pH, and reagent dosage influence performance. Next, the discussion turns to novel adaptations, such as US/photo-Fenton and US/electro-Fenton methods, and their roles in sludge treatment and related applications. Lastly, the review addresses the current challenges to its widespread implementation and outlines future research needs. Overall, the review emphasizes the recent progress and promising potential of US/Fenton as a robust wastewater remediation approach.

由于其产生极具活性的氧化剂（如OH）的能力，最终氧化引起了越来越多的关注。特别是，Fenton化学和超声波（US）技术已经证明了降解废水中抗性污染物的巨大潜力。US/Fenton技术是用Fenton试剂进行超声处理，增强OH自由基的生成，提高治疗效果。本文审查了与US/Fenton相关的理论基础、操作有效性和最新发展。首先，该报告概述了Fenton、超声波和US/Fenton机制，无论是单独的还是组合的。然后，分析了超声频率、能量输入、pH、试剂用量等变量对性能的影响。接下来，讨论转向新的适应性，如US/photo-Fenton和US/electro-Fenton方法，以及它们在污泥处理和相关应用中的作用。最后，该综述指出了其广泛实施的当前挑战，并概述了未来的研究需求。总体而言，综述强调了US/Fenton作为一种强大的废水修复方法的最新进展和前景。

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引用次数: 0

Impact of ultrasound-assisted single washing process on tilapia mince: Biochemical changes, structural modifications, and gel formation 超声辅助单次洗涤过程对罗非鱼肉糜的影响：生化变化、结构修饰和凝胶形成

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-14 DOI: 10.1016/j.ultsonch.2025.107707

Ali Hamzeh , Lobdaw Saelee , Kanjana Thumanu , Jae W. Park , Jirawat Yongsawatdigul

Ultrasound (US)-assisted single washing was applied to reduce water usage in tilapia mince washing during surimi production. The mince-to-water ratio of 1:2 in US-assisted washing was compared with ratios of 1:2 and 1:3 in conventional washing (CW−2 and CW−3, respectively). Screening of US power revealed the greatest effect at an intensity of 3.19 W/cm² on mince whiteness (p < 0.05), without damage to protein polypeptide chains, and no extensive biochemical changes. Subsequently, the mince was subjected to various US exposure times of 1, 3, and 5 min (US−1, US−3, and US−5, respectively) at 3.19 W/cm², maintaining the same total washing time of 10 min across all treatments. US-assisted washing increased myofibrillar protein loss compared with that with CW, as indicated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and the loss increased with longer exposure time—from 7.57 % in US−1 to 12.76 % in US−5. The US−1-washed mince exhibited the highest Ca²⁺–ATPase activity and reactive sulfhydryl (SH) content, even higher than that of CW−3 (p < 0.05). Random coil structures decreased in US−5, while other secondary structures did not change significantly. Tertiary structure analysis using Raman spectroscopy revealed comparable tyrosine and tryptophan exposure in US−1, US−3, and CW−3, which may contribute to the increased breaking force and distance through higher extent of hydrophobic interactions in their corresponding surimi gels compared with CW−2 and US − 5 (p < 0.05). Oxidation of SH groups and hydrophobic interactions increased in US−3 and US−5 (p < 0.05). US−1 was identified as the optimal condition for a single washing of tilapia mince to reduce water usage with minimal negative effects on protein.

为了减少罗非鱼糜在鱼糜生产过程中的洗涤用水量，采用超声辅助单次洗涤。将us辅助洗涤中1:2的肉水比与1:2和1:3的常规洗涤（分别为CW−2和CW−3）进行比较。US功率筛选结果显示，3.19 W/cm2强度对肉糜白度影响最大（p <； 0.05），对蛋白多肽链无损伤，且无广泛的生化变化。随后，将肉糜以3.19 W/cm2的速度进行1、3和5 min（分别为US - 1、US - 3和US - 5）的不同US暴露时间，在所有处理中保持相同的10 min的总洗涤时间。十二烷基硫酸钠-聚丙烯酰胺凝胶电泳显示，与连续洗涤相比，超声辅助洗涤增加了肌原纤维蛋白的损失，并且随着暴露时间的延长，损失从US−1的7.57 %增加到US−5的12.76 %。US−1水洗肉糜Ca2+ - atp酶活性和活性巯基（SH）含量最高，甚至高于CW−3水洗肉糜（p <； 0.05）。随机线圈结构在US−5中减少，而其他二级结构没有明显变化。利用拉曼光谱进行三级结构分析，发现US−1、US−3和CW−3中酪氨酸和色氨酸的暴露程度相当，与CW−2和US − 5相比，这可能有助于通过在相应的鱼糜凝胶中更高程度的疏水相互作用来增加断裂力和距离（p <； 0.05）。在US - 3和US - 5中，SH基团的氧化和疏水相互作用增加（p <； 0.05）。US - 1被确定为罗非鱼肉末单次洗涤的最佳条件，以减少水的使用，对蛋白质的负面影响最小。

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引用次数: 0

Different responses of fish/microbial transglutaminase to salt and ultrasound: Implications for myosin cross-linking 鱼/微生物转谷氨酰胺酶对盐和超声的不同反应：对肌球蛋白交联的影响

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-13 DOI: 10.1016/j.ultsonch.2025.107723

Xia Gao , Meng Gui , Gang Yu , Yongqiang Zhao , Liang Gao , Ru Liu

This study investigated the differential responses of fish transglutaminase (FTGase) and microbial transglutaminase (MTGase) to NaCl concentrations and high intensity ultrasound (HIU) during myosin cross-linking. Increasing NaCl concentrations enhanced MTGase activity by 34.5% at 0.8 mol/L compared to the control without NaCl. This enhancement was accompanied by structural unfolding, as evidenced by increased UV absorption intensity, which indicated greater exposure of aromatic residues. In contrast, FTGase activity progressively declined with increasing NaCl concentrations, with minimal structural changes observed. Given its Ca²⁺-independent property, MTGase was used to explore the synergistic effect of HIU and NaCl. The combination of 400 W HIU and 0.3 mol/L NaCl induced the most pronounced structural changes in MTGase, which exposed some buried reactive sulfhydryl groups and elevated activity by 17.0%. Furthermore, HIU pretreatment of both enzymes enhanced their catalytic efficiency for myosin cross-linking, as evidenced by increased formation of ε-(γ-Glu)-Lys isopeptide bonds. Notably, while HIU-pretreated FTGase improved the water holding capacity (WHC) of myosin samples, HIU-pretreated MTGase likely induced excessive cross-linking, which paradoxically reduced WHC. Conversely, applying HIU directly to preformed enzyme-myosin complexes disrupted established cross-links. These findings provide a basis for optimizing transglutaminase applications in food processing using HIU.

本研究研究了肌球蛋白交联过程中鱼类谷氨酰胺转酶（FTGase）和微生物谷氨酰胺转酶（mtase）对NaCl浓度和高强度超声（HIU）的差异反应。当NaCl浓度为0.8 mol/L时，与不添加NaCl的对照相比，增加NaCl浓度可使mtase活性提高34.5% %，并伴随结构展开，表明芳香残基暴露程度增加。相反，随着NaCl浓度的增加，FTGase活性逐渐下降，结构变化很小。考虑到mtase对Ca2+的依赖性，我们利用它来研究HIU和NaCl的协同作用。400 W / HIU和0.3 mol/L NaCl的组合对mtase的结构变化最为显著，暴露了一些埋藏的活性巯基，使活性提高了17.0 %。此外，HIU预处理两种酶都提高了它们对肌球蛋白交联的催化效率，ε-(γ-Glu)- lys异肽键的形成增加。值得注意的是，虽然HIU预处理的FTGase提高了肌球蛋白样品的持水能力（WHC），但HIU预处理的MTGase可能诱导过度交联，从而矛盾地降低了WHC。相反，将HIU直接应用于预形成的酶-肌球蛋白复合物会破坏已建立的交联。研究结果为优化谷氨酰胺转肽类酶在HIU食品加工中的应用提供了依据。

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引用次数: 0

Ultrasound-assisted extraction of bioactive compounds from pomegranate peel and seed: A comprehensive review of key parameters and optimization strategies 超声辅助提取石榴皮和石榴籽中生物活性物质：关键参数及优化策略综述

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-13 DOI: 10.1016/j.ultsonch.2025.107722

Fatima Shehzadi , Muhammad Shoaib , Salman Munir , Gholamreza Abdi

Pomegranate (Punica granatum L.) peel and seeds are rich in phenolics, flavonoids, anthocyanins, ellagitannins, tannins, and punicic acid, which exhibit potent antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. Conventional extraction methods, such as maceration, Soxhlet extraction, and hydrodistillation, are limited by excessive solvent and energy consumption, prolonged extraction times, and degradation of thermolabile compounds. Ultrasound-assisted extraction (UAE) has emerged as a sustainable and efficient alternative, utilizing acoustic cavitation to disrupt cell walls, enhance solvent penetration, and accelerate mass transfer. This review presents a comprehensive and UAE-specific synthesis of research on pomegranate peel and seed bioactives, focusing on the effect of key parameters ultrasonic power, frequency, extraction time, temperature, solvent system, solid-to-solvent ratio, and particle size on extraction efficiency and compound stability. Optimization strategies based on Response Surface Methodology, Box-Behnken Design, and Artificial Neural Networks are critically discussed to demonstrate their roles in maximizing yield and predicting extraction performance. Structural and spectroscopic studies confirming ultrasound-induced morphological disruption and molecular interactions are also summarized. This review uniquely synthesizes UAE-specific process parameters, optimization models, and structural characterization for both pomegranate peel and seed within a green valorization framework. Comparative analysis highlights the UAE superior performance over conventional and hybrid methods (microwave-, enzyme-, or deep eutectic solvent-assisted extractions). The review also identifies persisting challenges related to process scale-up, standardization of reporting metrics, and in vivo bioavailability assessment. Overall, this work provides an updated framework for improving extraction efficiency and supports the green valorization of pomegranate by-products into functional ingredients for food, nutraceutical, cosmetic, and pharmaceutical industries.

石榴（Punica granatum L.）果皮和种子富含酚类物质、类黄酮、花青素、鞣花单宁、单宁和石榴酸，具有强大的抗氧化、抗菌、抗炎和抗癌特性。传统的提取方法，如浸渍法、索氏提取法和加氢蒸馏法，由于溶剂和能量消耗过多、提取时间延长以及热稳定性化合物的降解而受到限制。超声辅助萃取（UAE）已经成为一种可持续和高效的替代方法，利用声空化破坏细胞壁，增强溶剂渗透，加速传质。本文综述了石榴皮和石榴籽生物活性物质的综合合成研究，重点介绍了超声功率、频率、提取时间、温度、溶剂体系、固液比和粒径等关键参数对提取效率和化合物稳定性的影响。本文讨论了基于响应面法、Box-Behnken设计和人工神经网络的优化策略，以证明它们在最大化产量和预测提取性能方面的作用。结构和光谱研究证实超声诱导的形态破坏和分子相互作用也进行了总结。这篇综述独特地综合了阿联酋特定的工艺参数，优化模型，以及在绿色增值框架内石榴皮和种子的结构表征。对比分析强调了阿联酋优越的性能优于传统和混合方法（微波，酶，或深共晶溶剂辅助提取）。该综述还确定了与工艺规模扩大、报告指标标准化和体内生物利用度评估相关的持续挑战。总之，本研究为提高石榴的提取效率提供了一个新的框架，并支持石榴副产物绿色增值为食品、保健品、化妆品和制药等行业的功能性成分。

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引用次数: 0

Preparation and characterization of ultrasound-mediated Ocimum basilicum L. essential oil nanoemulsion and its application in meat preservation 超声介导罗勒精油纳米乳的制备、表征及其在肉类保鲜中的应用

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-13 DOI: 10.1016/j.ultsonch.2025.107721

Yue Wang , Weixuan Pan , Xiangjun Yang , Ende Song , Hui Zhang , Yiming Liu , Kehui Wang , Huiwen Wu , Qi Liu

In this study, a stable basil oil nanoemulsion was prepared by emulsifier-assisted ultrasonication. The optimized formulation exhibited excellent physical stability under ambient, refrigerated (4 °C), and heated (55 °C) conditions. It demonstrated strong antibacterial activity against E. coli and S. aureus, inducing membrane disruption and oxidative stress, as evidenced by elevated ROS and MDA levels. The nanoemulsion also showed significant antioxidant capacity, scavenging 95 % of DPPH and 86 % of ABTS radicals and achieving a FRAP value of 14.6 µmol/g at 200 µg/mL. Cytotoxicity analysis confirmed high biocompatibility, with cell viability exceeding 83 % in L02 and BEAS-2B cells at 16 mg/mL. When applied to beef packaging, the nanoemulsion effectively maintained pH, reduced microbial counts, and suppressed TVB-N accumulation, thereby prolonging meat freshness. These findings highlight its potential as a multifunctional preservative for food and biomedical applications.

本研究采用乳化剂辅助超声法制备了稳定的罗勒油纳米乳。优化后的配方在室温、冷藏（4 °C）和加热（55 °C）条件下均表现出优异的物理稳定性。它对大肠杆菌和金黄色葡萄球菌具有很强的抗菌活性，可以诱导膜破坏和氧化应激，这可以通过提高ROS和MDA水平来证明。纳米乳还显示出显著的抗氧化能力，清除95 %的DPPH和86 %的ABTS自由基，在200 µg/mL时达到14.6 µmol/g的FRAP值。细胞毒性分析证实了高的生物相容性，在16 mg/mL浓度下，L02和BEAS-2B细胞的细胞存活率超过83 %。当应用于牛肉包装时，纳米乳有效地维持了pH值，减少了微生物数量，抑制了TVB-N的积累，从而延长了肉类的新鲜度。这些发现突出了其作为食品和生物医学用途的多功能防腐剂的潜力。

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引用次数: 0

Application potential of Lysimachia christinae Hance polysaccharides in kidney stone prevention/treatment: a multidimensional comparison between ultrasonic-assisted extraction and hot water extraction 枸杞子多糖在防治肾结石中的应用潜力：超声辅助提取与热水提取的多维比较

IF 9.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry

Pub Date : 2025-12-13 DOI: 10.1016/j.ultsonch.2025.107720

Jinfu Wang , Jiaxing Lin , Jiayue Wu , Honghong Pan , Jiaxuan Liao , Qinghui Lu , Ruo Wang , Jinfeng Wu , Jiawen Wang

Lysimachia christinae Hance (LCH), a traditional Chinese herbal medicine, possesses the effects of “clearing heat and promoting diuresis, relieving stranguria and expelling stones, and detoxifying and protecting the kidneys”. This study for the first time developed an efficient, green, and economical ultrasonic-assisted extraction (UAE) process for extracting LCH polysaccharides (LCHP-UAE). Meanwhile, it systematically investigated the mechanisms of action of UAE and hot water extraction (HWE) technologies for extracting LCH polysaccharides. Finally, it comparatively analyzed the differences in physicochemical properties, functional characteristics, and bioactivities between LCHP-UAE and LCH polysaccharides obtained by HWE (LCHP-HWE). It was found that under the optimal operating conditions of UAE obtained by response surface methodology optimization, the extraction yield of LCHP-UAE reached 8.25 ± 0.13 %. Compared with HWE, UAE strongly disrupted the cell walls of raw materials through cavitation effect and mechanical vibration, thereby improving mass transfer capacity. Compared with LCHP-HWE, LCHP-UAE exhibited characteristics such as lower M_W and smaller particle size, increased content of uronic acid, better thermal stability, and stronger water- and oil-holding capacities.Owing to its unique structural advantages, LCHP-UAE showed superior antioxidant activity and kidney stone inhibitory effect. In conclusion, this study establishes a robust theoretical foundation for the efficient utilization of LCH and the deployment of LCHP-UAE in contexts including the food industry and kidney stone intervention.

冬青是一种传统的中草药，具有“清热利尿、化尿排结石、解毒护肾”的功效。本研究首次建立了一种高效、绿色、经济的超声辅助提取法提取枸杞多糖（LCHP-UAE）。同时，系统地考察了UAE和热水浸提技术提取枸杞多糖的作用机理。最后，比较分析了LCHP-UAE多糖与HWE法获得的lchp多糖（LCHP-HWE）在理化性质、功能特性和生物活性方面的差异。在响应面法优化得到的最佳操作条件下，LCHP-UAE的提取率为8.25 ± 0.13 %。与HWE相比，UAE通过空化效应和机械振动强烈破坏原料细胞壁，从而提高了传质能力。与LCHP-HWE相比，LCHP-UAE表现出MW更低、粒径更小、醛酸含量更高、热稳定性更好、持水和持油能力更强等特点。由于其独特的结构优势，LCHP-UAE具有良好的抗氧化活性和抑制肾结石的作用。总之，本研究为LCH的有效利用以及LCHP-UAE在食品工业和肾结石干预等领域的应用奠定了坚实的理论基础。

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引用次数: 0