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Skin-Inspired “Sweating Fabrics” with Directional Water Accumulation and Droplet Rolling Behavior for High-Performance Personal Moisture Management 皮肤启发的“出汗织物”,具有定向水积累和水滴滚动行为,用于高性能的个人水分管理
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-12-20 DOI: 10.1007/s42765-025-00629-3
Doudou Zhu, Xin Jiang, Jingyi Sun, Jichao Zhang, Wen Zhou, Shaohai Fu

Janus fabrics with moisture management enable directional water transport from the inner hydrophobic layer to the outer hydrophilic region, contributing to personalized moisture comfort. However, when the human body sweats profusely in high-temperature/high-humidity environments or during intense physical activities, current Janus fabrics encounter a daunting challenge of being saturated by sweat, generating unpleasant stuffiness and tight adhesion to the skin. Herein, inspired by the sweat glands in human skin, we propose an innovative “sweating fabric” with a uniquely patterned structure that features physical and chemical asymmetry, towards directional sweat accumulation and droplet rolling capabilities for high-performance personal moisture management. Unlike existing Janus fabrics where sweat permeates, spreads, and evaporates, our “sweating fabric” facilitates directional sweat transport to the outer surface where the sweat reaggregates into liquid droplets that drip off rather than spread or evaporate. By creatively constructing patterned water transport channels with asymmetric pore structure and wettability, each water transport channel of the “sweating fabric” has an outstanding directional water transport rate of 12.2 mL cm−2 min−1 while rendering sweat droplets to slide easily [sliding angle of (45 ± 2)°], which enables sustainable and swift sweat transport, thus opening ample opportunities for advanced fiber materials for wound care, biofluid monitoring, and microfluid control.

Graphical Abstract

具有水分管理功能的Janus织物能够从内部疏水层向外部亲水区域定向输送水分,有助于个性化的水分舒适度。然而,当人体在高温/高湿环境或激烈的体育活动中大量出汗时,目前的Janus面料遇到了一个令人生畏的挑战,即被汗水饱和,产生令人不快的闷热感,并与皮肤紧密粘附。在此,受人体皮肤汗腺的启发,我们提出了一种创新的“出汗织物”,它具有独特的图案结构,具有物理和化学不对称的特点,具有定向汗液积累和液滴滚动能力,可实现高性能的个人水分管理。与现有的Janus面料不同,汗水会渗透、扩散和蒸发,我们的“排汗面料”有助于汗水定向运输到外表面,在那里汗水重新聚集成液滴滴下,而不是扩散或蒸发。通过创造性地构建具有非对称孔隙结构和润湿性的图案输水通道,“出汗织物”的每个输水通道具有12.2 mL cm - 2 min - 1的定向输水速率,同时使汗滴易于滑动[滑动角为(45±2)°],从而实现可持续和快速的汗液运输,从而为先进的纤维材料提供了大量的机会,用于伤口护理,生物流体监测和微流体控制。图形抽象
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引用次数: 0
Smart Textiles with Living Interfaces: Microbiome–Electronics Integration for Advanced Skin Health Management 智能纺织品与生活界面:微生物电子集成先进的皮肤健康管理
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-18 DOI: 10.1007/s42765-025-00625-7
Hanbai Wu, Yang Ming, Shuo Shi, Chuanwei Zhi, Daming Chen, Xin Hu, Rujun Yu, Shuang Qiu, Hang Mei Leung, Jinlian Hu, Jooyoun Kim, Joanne Yip, Bin Fei

Smart textiles have emerged as a transformative class of materials that extend the role of conventional fabrics into personalized health management. This evolution is driven by the seamless integration of textiles with flexible electronics, enabling new paradigms in skin-interfaced systems. In the exploration of novel smart textiles for skin health, microorganisms living in the skin microenvironment necessitate consideration. Skin microbiomes are essential to skin homeostasis and balance the barrier to infection. Moreover, microbes have been extensively explored as functional components in skin health monitoring and therapeutic devices. In this review, the distribution of skin microbes, interactions between host and resident microbiota, and mechanisms of microbial functions in the skin microenvironment are introduced systematically. In addition, recent progress in skin-based flexible devices for health management, and design and fabrication methods for smart textiles are discussed. However, some challenges still exist in association with the integration of microbes into smart textiles, such as the biosafety of microbes, long-term storage, and activation. This review provides a summary of innovative technologies including microencapsulation, synthetic biology, optogenetics, and artificial intelligence for microbe-integrated smart textiles. Next-generation smart textiles will hold significant promise for precision skin disease diagnostics, personalized therapeutics, skin status monitoring, and intelligence regulation.

Graphical Abstract

智能纺织品已经成为一种变革性的材料,将传统织物的作用扩展到个性化的健康管理中。这种演变是由纺织品与柔性电子产品的无缝集成驱动的,从而实现了皮肤界面系统的新范例。在探索用于皮肤健康的新型智能纺织品时,必须考虑生活在皮肤微环境中的微生物。皮肤微生物群对皮肤内稳态和平衡感染屏障至关重要。此外,微生物作为皮肤健康监测和治疗装置的功能成分已被广泛探索。本文就皮肤微生物的分布、宿主与常驻微生物群的相互作用以及皮肤微环境中微生物功能的机制等方面进行了系统的介绍。此外,还讨论了基于皮肤的健康管理柔性设备的最新进展,以及智能纺织品的设计和制造方法。然而,将微生物整合到智能纺织品中仍然存在一些挑战,如微生物的生物安全性、长期储存和激活。本文综述了微胶囊化、合成生物学、光遗传学、人工智能等微生物集成智能纺织品的创新技术。下一代智能纺织品将在精确皮肤病诊断、个性化治疗、皮肤状态监测和智能调节方面发挥重要作用。图形抽象
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引用次数: 0
Janus Adhesive Dressing with Macro/Micro Dual Design Enabling Sequential Microenvironment Regulation for Scarless Wound Healing 具有宏/微双重设计的Janus胶粘剂敷料,可实现无疤痕伤口愈合的顺序微环境调节
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-13 DOI: 10.1007/s42765-025-00620-y
Meimei Fu, Yue Li, Yitao Zhao, Yuting Zhu, Zhou Fang, Zhuoyi Huang, Wenjun Luo, Xinyu Huang, Jintao Li, Zhiqi Hu, Keke Wu, Jinshan Guo

Continuous wound healing micro-environment regulation and timely angiogenesis modulation are crucial for preventing excessive collagen accumulation and promoting scarless wound healing. Herein, a bilayer silk fibroin (SF)-based Janus adhesive dressing (SCE) was developed, featuring a lower layer of Ca2+/Zn2+-modified silk fibroin (SCZ) and an upper layer of silk fibroin core–shell electrospun fibers with epigallocatechin gallate (EGCG) encapsulated in the core (SE). The Ca2+/Zn2+ modification induced decrystallization of the SF, thereby conferring strong tissue adhesion to the lower SCZ layer and providing rapid hemostasis and initial anti-inflammatory effects upon wound contact. The macro (double layers) and micro (core–shell) dual design enabled EGCG to be slowly released during the early healing stage, exerting both antioxidant and synergistic anti-inflammatory effects in conjunction with Zn2+. With complete absorption of the lower layer and degradation of the shell of the upper layer, substantial amounts of EGCG were continuously released to inhibit angiogenesis during the later healing stages. In vivo studies employing both rat full-thickness skin wound models and rabbit ear scar models further confirmed the potential of SCE to promote scarless wound healing by combining early-stage hemostatic, antimicrobial, antioxidant, and anti-inflammatory properties with late-stage angiogenesis braking to reduce vascular density and blood supply, thereby allowing extracellular matrix remodeling and preventing collagen overproduction and deposition.

Graphical Abstract

持续的伤口愈合微环境调节和及时的血管生成调节是防止胶原过度积累和促进无疤痕伤口愈合的关键。本文研制了一种双层丝素蛋白(SF)基Janus粘着剂敷料(SCE),其下层为Ca2+/Zn2+修饰的丝素蛋白(SCZ),上层为丝素蛋白核-壳静电纺丝纤维,核心(SE)内包裹着表没食子茶素没食子酸酯(EGCG)。Ca2+/Zn2+修饰诱导SF脱晶,从而赋予较低SCZ层的强组织粘连,并在伤口接触时提供快速止血和初始抗炎作用。宏观(双层)和微观(核壳)双重设计使EGCG在愈合早期缓慢释放,与Zn2+一起发挥抗氧化和协同抗炎作用。随着下层的完全吸收和上层外壳的降解,大量的EGCG被持续释放,以抑制后期愈合阶段的血管生成。采用大鼠全层皮肤创面模型和兔耳瘢痕模型的体内研究进一步证实了SCE促进无疤痕创面愈合的潜力,SCE将早期的止血、抗菌、抗氧化和抗炎特性与晚期血管生成抑制结合起来,降低血管密度和血液供应,从而允许细胞外基质重塑,防止胶原过度生成和沉积。图形抽象
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引用次数: 0
Translational Potential of an Electrospun Polycaprolactone Scaffold for Anterior Cruciate Ligament Reconstruction. 静电纺聚己内酯支架用于前交叉韧带重建的平移电位。
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-03 DOI: 10.1007/s42765-025-00632-8
Jinrong Lin, Kaili Chen, Meng Liang, Tania Choreno Machain, Daisy Crouch, Simona Mengoli, George Exley, Alma Zaplluzha, Mathew Baldwin, William Jackson, Thomas Cosker, Sarah Snelling, Andrew Carr, Gordon Blunn, Andrew Price, Pierre-Alexis Mouthuy

Anterior cruciate ligament (ACL) injuries are common and often require surgical reconstruction. Autografts remain the clinical standard for ACL reconstruction (ACLR) but are limited by donor site morbidity, inconsistent outcomes, and supply constraints. Here, we report the development of electrospun ligament (ES-Lig), a fully degradable, electrospun scaffold composed of poly(ε-caprolactone) (PCL) designed to mimic the extracellular matrix (ECM) of the native ACL. A scalable manufacturing process was established, incorporating electrospinning, filament stretching, alignment, and braiding. ES-Lig demonstrated controlled in vitro degradation over 12 months while retaining sufficient mechanical strength for early-stage healing. Mechanical characterisation revealed tensile properties and fixation stability comparable to autografts. In vitro biocompatibility was confirmed through cytotoxicity assays, patient-derived ACL explants, and direct cell growth onto the material. In an ovine ACLR model, ES-Lig enabled functional recovery, tissue infiltration throughout its length, and joint stability within 10 weeks post-implantation. Histological and imaging analyses confirmed graft-bone integration, vascularisation, and early ligamentisation. These findings establish ES-Lig as a promising, clinically translatable scaffold for next-generation ACL repair.

前交叉韧带(ACL)损伤是常见的,往往需要手术重建。自体移植物仍然是ACL重建(ACLR)的临床标准,但受供体部位发病率、结果不一致和供应限制的限制。在这里,我们报道了电纺丝韧带(ES-Lig)的发展,这是一种完全可降解的电纺丝支架,由聚-己内酯(PCL)组成,旨在模仿天然ACL的细胞外基质(ECM)。建立了可扩展的制造工艺,包括静电纺丝,长丝拉伸,对准和编织。ES-Lig在12个月的体外降解过程中表现出可控,同时为早期愈合保留了足够的机械强度。力学特性显示拉伸性能和固定稳定性与自体移植物相当。体外生物相容性通过细胞毒性试验、患者源性ACL外植体和直接细胞生长在材料上证实。在羊ACLR模型中,ES-Lig能够在植入后10周内实现功能恢复、组织浸润和关节稳定性。组织学和影像学分析证实植骨融合、血管化和早期韧带形成。这些发现确立了ES-Lig作为下一代ACL修复的有前途的、临床可翻译的支架。
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引用次数: 0
Respiratory Health Monitoring System Based on “Sensing Material–Medical Device–Algorithm” Framework 基于“传感材料-医疗器械-算法”框架的呼吸健康监测系统
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-10-31 DOI: 10.1007/s42765-025-00608-8
Changsheng Lu, Xiao Wang, Yingqi Yang, Keyi Li, Yihua Lin, Guiyang Lin, Guanying Zheng, Baosong Xie, Zerong Jiang, Zongqu Xu, Yali Liu, Sunkui Ke, Boyu Zhang, Kunlin Han, Yongxiang Huang, Lina Cui, Xiang Yang Liu

Flexible sensing technologies for dynamic respiratory monitoring face critical limitations in environmental robustness and signal resolution accuracy. To address these challenges, a humidity-sensitive dielectric material was developed through intermolecular force modulation, synergistically integrated with a hermetically sealed digital mask to establish a medical-grade respiratory monitoring platform. A novel quantitative respiratory waveform analytical model was proposed, transcending conventional flexible sensors’ capability of merely tracking respiratory rhythms to enable precise quantification of pulmonary function parameters, including peak expiratory flow (PEF) and forced vital capacity (FVC). Leveraging a Darcy’s law-based porous media gas dynamics model, a linear response mechanism was identified between sensing signals and airflow/volume parameters (R2 > 0.995). Time–frequency characteristics of respiratory waveforms were extracted via synchrosqueezed wavelet transforms, revealing robust correlations between spectral signatures and physical activity intensity. Clinical validation in chronic obstructive pulmonary disease (COPD) cohorts demonstrated the system’s efficacy in detecting characteristic patterns of airway obstruction and diminished pulmonary elasticity, enabling early-stage diagnostics. Furthermore, a 1-dimensional convolutional neural network (1D-CNN) achieved high-accuracy cough event recognition (95.24% precision). A vertically integrated “sensing material–medical device–algorithm” framework is pioneered for home-based artificial intelligence (AI) respiratory disease management, advancing flexible electronics from physiological tracking to precision medical applications.

Graphical Abstract

用于动态呼吸监测的柔性传感技术在环境鲁棒性和信号分辨率精度方面面临着严重的限制。为了应对这些挑战,通过分子间力调制开发了一种对湿度敏感的介电材料,并与密封数字面罩协同集成,建立了一个医疗级呼吸监测平台。提出了一种新的定量呼吸波形分析模型,超越了传统柔性传感器仅跟踪呼吸节律的能力,能够精确量化肺功能参数,包括呼气峰流量(PEF)和用力肺活量(FVC)。利用基于Darcy定律的多孔介质气体动力学模型,确定了传感信号与气流/容积参数之间的线性响应机制(R2 > 0.995)。通过同步压缩小波变换提取呼吸波形的时频特征,揭示了频谱特征与身体活动强度之间的鲁棒相关性。慢性阻塞性肺疾病(COPD)队列的临床验证表明,该系统在检测气道阻塞和肺弹性降低的特征模式方面的有效性,从而实现早期诊断。一维卷积神经网络(1D-CNN)的咳嗽事件识别准确率达到95.24%。首创“传感材料-医疗设备-算法”垂直整合的家庭人工智能呼吸系统疾病管理框架,推动柔性电子从生理跟踪到精准医疗应用。图形抽象
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引用次数: 0
Dual-Mode, Sustainable Textile with Asymmetric Optical and Wettability Design for Efficient Personal Moisture–Thermal Management 双模式,可持续纺织品与不对称光学和润湿性设计,有效的个人湿热管理
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-10-27 DOI: 10.1007/s42765-025-00630-w
Tong Xue, Yan Yu, Ruijie Ma, Muyan Ma, Juan Li, Chaoxia Wang, Yunjie Yin

Integrating radiative cooling or solar heating into personal thermal management (PTM) textiles has attracted considerable interest. However, most current PTM textiles exhibit single functionality, limited biocompatibility and degradability, and the impact of intense perspiration is often ignored. Herein, a dual-mode polylactide-based PTM textile (DMTex) with asymmetric optical properties, wettability, and pore size distribution for efficient personal moisture and thermal management is designed via layered electrospinning. The unique optical structure and addition of functional particles endow the cooling side of DMTex with excellent solar reflectance (96.97%) and infrared emissivity (86.93%), whereas the heating side has 85.83% solar absorptance. Compared with white and black polylactic acid fabrics, DMTex achieves an additional cooling effect of 14.32 ℃ and a heating effect of 13.09 ℃ under 1100 W m−2 solar radiation. Moreover, the three-layer construction design endows DMTex with exceptional unidirectional moisture-wicking and anti-backflow performance. In addition, DMTex exhibits excellent wearability, biocompatibility, and degradability. Such a dual-mode and sustainable DMTex presents great potential for achieving efficient personal moisture and thermal comfort.

Graphical Abstract

将辐射冷却或太阳能加热集成到个人热管理(PTM)纺织品中已经引起了相当大的兴趣。然而,目前大多数PTM纺织品表现出单一的功能,有限的生物相容性和可降解性,并且经常忽视强排汗的影响。本文通过分层静电纺丝设计了一种具有非对称光学性能、润湿性和孔径分布的双模聚乳酸基PTM纺织品(DMTex),用于有效的个人水分和热管理。独特的光学结构和功能粒子的加入使DMTex冷却侧具有优异的太阳反射率(96.97%)和红外发射率(86.93%),而加热侧具有85.83%的太阳吸收率。与白色和黑色聚乳酸织物相比,DMTex在1100 W m−2太阳辐射下的额外冷却效果为14.32℃,加热效果为13.09℃。此外,三层结构设计使DMTex具有优异的单向排湿和防回流性能。此外,DMTex具有优异的耐磨性、生物相容性和可降解性。这种双模和可持续的DMTex呈现出巨大的潜力,实现高效的个人湿度和热舒适。图形抽象
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引用次数: 0
Core–Shell Yarn Woven Metafabric: Integrated Autonomous Sweat Transport and Radiative-Perspirative Cooling 核壳纱线编织超织物:集成自主汗水输送和辐射排汗冷却
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-10-20 DOI: 10.1007/s42765-025-00628-4
Maorong Zheng, Yalin Dong, Hongfang Liu, Jiayin Yang, Shuo Dong, Liming Wang, Xiaohong Qin

Although the bionic evaporative cooling mechanism is regarded as a key path to enhance the thermal management efficiency of the human body outdoors, the structural limitations of traditional fabrics and the bottleneck of heat transfer efficiency led to sweat retention, intensifying the skin’s heat load and restricting the realization of the goal of microenvironment comfort regulation. Here, a metafabric with unidirectional sweat transport and three cooling modes is innovatively fabricated by weaving core–shell yarns via mature weaving techniques. The gradient wetting structure formed in the fabric through the plasma treatment can pull liquid water out of the skin and diffuse it to the outer layer of the fabric for rapid evaporation (0.41 g h−1), which is in a leading position in the field of sweat evaporation of cotton materials. Meanwhile, the addition of heat-conducting substances in shell nanofibers has improved the sweat cooling utilization rate of cotton fabrics, providing an additional skin temperature drop of 3.5 ℃ through sweat evaporation. In the outdoor experiment simulating human sweating, a temperature reduction of 7 ℃ is observed for skin-covered metafabric compared with skin-covered cotton fabric. Owing to its exceptional performance, the metafabric can provide promising design guidelines for developing a thermal-moisture comfort textile.

Graphical Abstract

虽然仿生蒸发冷却机制被认为是提高人体户外热管理效率的关键途径,但传统面料的结构限制和传热效率瓶颈导致汗液滞留,加剧了皮肤热负荷,制约了微环境舒适调节目标的实现。本文采用成熟的织造技术,通过芯壳纱的织造,创新地制成了一种单向排汗、三种冷却方式的超织物。通过等离子体处理在织物中形成的梯度润湿结构,可以将液态水从皮肤中抽出,扩散到织物外层快速蒸发(0.41 gh−1),在棉质材料的汗液蒸发领域处于领先地位。同时,在壳纳米纤维中加入导热物质,提高了棉织物的汗液冷却利用率,通过汗液蒸发使皮肤温度额外降低3.5℃。在室外模拟人体出汗实验中,包皮超织物与包皮棉织物相比,温度降低了7℃。由于其优异的性能,这种超织物可以为开发热湿舒适纺织品提供有希望的设计指南。图形抽象
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引用次数: 0
A Double-Reactive Biodegradable Elastomer Enables Functional Modification of Fibrous Grafts for More Positive Regeneration of Arterial Tissues 一种双反应性可生物降解弹性体使纤维移植物功能改变,使动脉组织更积极地再生
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-10-20 DOI: 10.1007/s42765-025-00624-8
Yating Jia, Hao Lu, Xin Xu, Xiaojun Zhou, Yanan Pang, Chuanglong He, Lei Hou

Elastomers containing functional groups hold significant potential for soft tissue repair, particularly in vascular tissues; however, available materials of this type are scarce. In this study, we present a straightforward and easily synthesized biodegradable elastomer (named PGSCC), which was developed by incorporating citric acid and L-cysteine into the molecular structure of poly(glycerol sebacate) (PGS). This elastomer exhibits good elasticity, biocompatibility, and biodegradability comparable to PGS while also demonstrating enhanced reactivity due to the presence of two active functional groups: -COOH and -SH. This unique combination of exceptional properties endows PGSCC with significant potential for various biomedical applications, particularly for the bioactive modification of essential materials or implanted grafts. One notable example was the significantly improved effect of PGSCC-containing fibrous films on cell proliferation following appropriate modification through the PGSCC. By introducing PGSCC into our previously reported fibrous vascular graft, we obtained a new graft (M-Tri-layer tube) with functional groups that can be modified easily with vascular endothelial growth factor (VEGF) and heparin simultaneously. The VEGF/heparin dual-modified graft exhibited more favorable outcomes than the unmodified grafts in rabbits, particularly regarding neo-tissue formation and endothelialization during the early stages of implantation (within 16 weeks), demonstrating the excellent efficacy of PGSCC for vascular graft modification.

Graphical Abstract

含有官能团的弹性体在软组织修复方面具有重要的潜力,特别是在维管组织中;然而,这种类型的可用材料是稀缺的。在这项研究中,我们提出了一种简单且易于合成的可生物降解弹性体(PGSCC),该弹性体是通过将柠檬酸和l -半胱氨酸掺入聚甘油癸二酸酯(PGS)的分子结构中而开发的。该弹性体具有与PGS相当的良好弹性、生物相容性和生物降解性,同时由于-COOH和-SH两个活性官能团的存在,也表现出增强的反应性。这种独特的特性赋予了PGSCC在各种生物医学应用方面的巨大潜力,特别是在基本材料或植入式移植物的生物活性修饰方面。一个值得注意的例子是,经过适当的PGSCC修饰后,含有PGSCC的纤维膜对细胞增殖的影响显著改善。通过将PGSCC引入我们之前报道的纤维血管移植物中,我们获得了一种新的移植物(m -三层管),其功能基团可以同时被血管内皮生长因子(VEGF)和肝素修饰。VEGF/肝素双修饰的兔血管移植比未修饰的兔血管移植效果更好,特别是在植入早期(16周内)的新组织形成和内皮化方面,证明了PGSCC对血管移植的良好疗效。图形抽象
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引用次数: 0
Dual Biomimetic Nanofiber Conduits Enable Synergistic NGF Delivery and Endogenous Piezoelectric Stimulation for Peripheral Nerve Regeneration 双仿生纳米纤维导管实现神经生长因子的协同传递和内源性压电刺激周围神经再生
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-10-20 DOI: 10.1007/s42765-025-00627-5
Zhenwei Yi, Yaofa Lin, Rui Jing, Xiangru Feng, Xiaoxuan Lu, Diqi Tian, Haodong Lin, Liming Zhao

After peripheral nerve injury, decreased nerve growth factor (NGF) levels and interrupted bioelectrical signal transmission are key factors leading to delayed nerve regeneration. However, the nerve conduits currently applied in clinical practice fail to simultaneously achieve sustained nutritional support and electrical activity maintenance for the injured microenvironment, limiting their repair effects. Herein, a dual-functional-layer nerve conduit loaded with NGF and exhibiting a high piezoelectric response was fabricated using electrospinning technology. The inner layer was composed of heparin-functionalized chitosan nanofibers loaded with NGF (CPHN), whereas the outer layer was formed from polyvinylidene fluoride (PVDF) nanofibers incorporated with ZnO nanoparticles (PZ). The results showed that the heparin-functionalized chitosan nanofibers significantly enhanced the loading density and stability of NGF. Additionally, PZ nanofibers with 1 wt% ZnO generated stable and appropriate endogenous electrical stimulation under controlled external stimulation. In vitro experiments demonstrated that the combination of PZ and CPHN (PZ@CPHN) could compensate for TrkA receptor desensitization, improve NGF pharmacodynamics, and activate the NGF/TrkA signaling pathway to regulate PC12 cells proliferation, differentiation, and motility. In the rat sciatic nerve defect model, transplantation of the PZ@CPHN conduit significantly promoted the reconstruction of regenerated nerve tissue and the recovery of muscle motor function after 12 weeks, achieving a repair outcome comparable to that of autologous nerve transplantation. In summary, a novel therapeutic strategy combining NGF administration with endogenous electrical stimulation is proposed to accelerate peripheral nerve regeneration.

Graphical Abstract

周围神经损伤后,神经生长因子(NGF)水平下降和生物电信号传递中断是导致神经再生延迟的关键因素。然而,目前临床上应用的神经导管不能同时实现对损伤微环境的持续营养支持和电活动维持,限制了其修复效果。本文采用静电纺丝技术制备了一种具有高压电响应的神经纤维纤维双层神经导管。内层是由肝素功能化的壳聚糖纳米纤维负载NGF (CPHN)组成,而外层是由聚偏氟乙烯(PVDF)纳米纤维负载ZnO纳米粒子(PZ)组成。结果表明,肝素功能化壳聚糖纳米纤维显著提高了NGF的负载密度和稳定性。此外,ZnO含量为1 wt%的PZ纳米纤维在可控的外部刺激下产生稳定和适当的内源性电刺激。体外实验表明,PZ与CPHN (PZ@CPHN)联用可补偿TrkA受体脱敏,改善NGF药效学,激活NGF/TrkA信号通路,调节PC12细胞的增殖、分化和运动。在大鼠坐骨神经缺损模型中,PZ@CPHN导管移植在12周后显著促进了再生神经组织的重建和肌肉运动功能的恢复,修复效果与自体神经移植相当。综上所述,我们提出了一种新的治疗策略,将NGF与内源性电刺激结合起来,以加速周围神经的再生。图形抽象
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引用次数: 0
Integration of Color Construction and Mechanical Enhancement of High-Performance Polyimide Fiber in Supercritical Carbon Dioxide Fluid 超临界二氧化碳流体中高性能聚酰亚胺纤维的着色结构与力学增强的结合
IF 21.3 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-10-17 DOI: 10.1007/s42765-025-00619-5
Xin Chen, Xikai Ma, Rui Shang, Xin Zhao, Qinghua Zhang

The rigid molecular structure and inherent golden color of polyimide fibers pose a significant challenge for its color construction. Traditional dyeing methods often come at the expense of mechanical properties due to the swelling effect. Here, the supercritical carbon dioxide (scCO2) dyeing method was used to balance the contradictory relationship between color and mechanical properties of polyimide. Employing scCO2 fluid as the dyeing medium leverages its unique dissolution and diffusion properties to drive the dye deep into the fiber, thereby imparting the satisfactory color to the polyimide fiber with the uptake ratio of 31.46 mg/g and the color fastness of up to grade 5. Furthermore, the swelling effect of the carrier on the fibers and the optimization and arrangement effect of the fluid on the molecular chains produce a synergistic effect, resulting in the tensile strength increased by about 20%. Given its streamlined process, eco-friendly nature and consistent results, we anticipate this prospective approach to be a formidable competitor in the field of color construction of polyimide fibers.

Graphical Abstract

聚酰亚胺纤维具有刚性的分子结构和固有的金色,这对其色彩结构提出了重大挑战。传统的染色方法往往以牺牲机械性能为代价,因为膨胀效应。本文采用超临界二氧化碳(scCO2)染色法来平衡聚酰亚胺的颜色与力学性能之间的矛盾关系。采用scCO2流体作为染色介质,利用其独特的溶解和扩散特性,将染料深入到纤维中,从而使聚酰亚胺纤维获得满意的颜色,其吸收率为31.46 mg/g,色牢度达5级。此外,载体对纤维的膨胀效应和流体对分子链的优化排列效应产生协同效应,使拉伸强度提高约20%。鉴于其流线型工艺、环保性质和一致的结果,我们预计这种有前景的方法将成为聚酰亚胺纤维彩色结构领域的强大竞争对手。图形抽象
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期刊
Advanced Fiber Materials
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