Abstract This review provides an overview of the historical development and modern applications of femtosecond (fs) lasers in ophthalmology, with a focus on the optical concepts involved. fs-Laser technology is unique because it allows very precise cutting inside the eye through optically transparent tissue, without a need for any mechanical openings. fs-Lasers were historically first used for refractive cornea surgery, later also for therapeutic cornea procedures and lens surgery. Further new areas of ophthalmic application are under development. The latest laser system concept is low pulse energy and high pulse frequency: by using larger numerical aperture focusing optics, the pulse energy required for optical breakdown decreases, and athermal tissue cutting with minimal side effects is enabled.
{"title":"Femtosecond lasers for eye surgery applications: historical overview and modern low pulse energy concepts","authors":"T. Asshauer, C. Latz, A. Mirshahi, C. Rathjen","doi":"10.1515/aot-2021-0044","DOIUrl":"https://doi.org/10.1515/aot-2021-0044","url":null,"abstract":"Abstract This review provides an overview of the historical development and modern applications of femtosecond (fs) lasers in ophthalmology, with a focus on the optical concepts involved. fs-Laser technology is unique because it allows very precise cutting inside the eye through optically transparent tissue, without a need for any mechanical openings. fs-Lasers were historically first used for refractive cornea surgery, later also for therapeutic cornea procedures and lens surgery. Further new areas of ophthalmic application are under development. The latest laser system concept is low pulse energy and high pulse frequency: by using larger numerical aperture focusing optics, the pulse energy required for optical breakdown decreases, and athermal tissue cutting with minimal side effects is enabled.","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":"10 1","pages":"393 - 408"},"PeriodicalIF":1.8,"publicationDate":"2021-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42292947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-25Epub Date: 2021-10-13DOI: 10.1515/aot-2021-0045
Yicheng Wang, Sergei Tomilov, Clara J Saraceno
High average power femtosecond lasers have made spectacular progress in the last decades - moving from laboratory-based systems with maximum average powers of tens of watts to kilowatt-class mature industrial systems in a short time. The availability of such systems opens new possibilities in many fields; one of the most prominent ones that have driven many of these technological advances is precise high-speed material processing, where ultrashort pulses have long been recognized to provide highest precision processing of virtually any material, and high average power extends these capabilities to highest processing rates. Here, we focus our attention on one high-average power technology with large unexplored potential for this specific application: directly modelocked multi-MHz repetition frequency high-power thin-disk oscillators. We review their latest state-of-the-art and discuss future directions and challenges, specifically with this application field in mind.
{"title":"High-power modelocked thin-disk oscillators as potential technology for high-rate material processing.","authors":"Yicheng Wang, Sergei Tomilov, Clara J Saraceno","doi":"10.1515/aot-2021-0045","DOIUrl":"https://doi.org/10.1515/aot-2021-0045","url":null,"abstract":"<p><p>High average power femtosecond lasers have made spectacular progress in the last decades - moving from laboratory-based systems with maximum average powers of tens of watts to kilowatt-class mature industrial systems in a short time. The availability of such systems opens new possibilities in many fields; one of the most prominent ones that have driven many of these technological advances is precise high-speed material processing, where ultrashort pulses have long been recognized to provide highest precision processing of virtually any material, and high average power extends these capabilities to highest processing rates. Here, we focus our attention on one high-average power technology with large unexplored potential for this specific application: directly modelocked multi-MHz repetition frequency high-power thin-disk oscillators. We review their latest state-of-the-art and discuss future directions and challenges, specifically with this application field in mind.</p>","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":"10 4-5","pages":"247-261"},"PeriodicalIF":1.8,"publicationDate":"2021-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40540129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patryk Mlyniuk, Ewa Maczynska-Walkowiak, Jagoda Rzeszewska-Zamiara, I. Grulkowski, B. Kaluzny
Abstract The cornea is a part of the anterior segment of the eye that plays an essential optical role in refracting the light rays on the retina. Cornea also preserves the shape of an eyeball and constitutes a mechanical barrier, protecting the eye against the factors of the external environment. The structure of the cornea influences its biomechanical properties and ensures appropriate mechanical load transfer (that depends on the external environment and the intraocular pressure) while maintaining its shape (to a certain extent) and its transparency. The assessment of the corneal biomechanics is important in clinical ophthalmology, e.g. in the diagnosis of ectatic corneal diseases, for precise planning of the refractive surgery, and in accurate determination of the intraocular pressure. A standard technique to determine corneal biomechanics requires the application of well-defined mechanical stimulus (e.g. air puff) and performing simultaneous imaging of the response of the tissue to the stimulus. A number of methods to assess the biomechanical properties of the cornea have been developed, including ultrasound, magnetic resonance imaging, and optical methods as visualization modalities. Commercially available methods include the ocular response analyzer (ORA) and corneal visualization scheimpflug technology (Corvis ST). Currently advanced research is conducted using optical coherence tomography (OCT). The extension of OCT called optical coherence elastography (OCE) possesses high clinical potential due to the imaging speed, noncontact character, and high resolution of images.
{"title":"Probing biomechanical properties of the cornea with air-puff-based techniques – an overview","authors":"Patryk Mlyniuk, Ewa Maczynska-Walkowiak, Jagoda Rzeszewska-Zamiara, I. Grulkowski, B. Kaluzny","doi":"10.1515/aot-2021-0042","DOIUrl":"https://doi.org/10.1515/aot-2021-0042","url":null,"abstract":"Abstract The cornea is a part of the anterior segment of the eye that plays an essential optical role in refracting the light rays on the retina. Cornea also preserves the shape of an eyeball and constitutes a mechanical barrier, protecting the eye against the factors of the external environment. The structure of the cornea influences its biomechanical properties and ensures appropriate mechanical load transfer (that depends on the external environment and the intraocular pressure) while maintaining its shape (to a certain extent) and its transparency. The assessment of the corneal biomechanics is important in clinical ophthalmology, e.g. in the diagnosis of ectatic corneal diseases, for precise planning of the refractive surgery, and in accurate determination of the intraocular pressure. A standard technique to determine corneal biomechanics requires the application of well-defined mechanical stimulus (e.g. air puff) and performing simultaneous imaging of the response of the tissue to the stimulus. A number of methods to assess the biomechanical properties of the cornea have been developed, including ultrasound, magnetic resonance imaging, and optical methods as visualization modalities. Commercially available methods include the ocular response analyzer (ORA) and corneal visualization scheimpflug technology (Corvis ST). Currently advanced research is conducted using optical coherence tomography (OCT). The extension of OCT called optical coherence elastography (OCE) possesses high clinical potential due to the imaging speed, noncontact character, and high resolution of images.","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":"10 1","pages":"375 - 391"},"PeriodicalIF":1.8,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44013095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mordmüller, V. Kleyman, M. Schaller, M. Wilson, D. Theisen-Kunde, K. Worthmann, M. Müller, R. Brinkmann
Abstract Laser photocoagulation is one of the most frequently used treatment approaches in ophthalmology for a variety of retinal diseases. Depending on indication, treatment intensity varies from application of specific micro injuries down to gentle temperature increases without inducing cell damage. Especially for the latter, proper energy dosing is still a challenging issue, which mostly relies on the physician’s experience. Pulsed laser photoacoustic temperature measurement has already proven its ability for automated irradiation control during laser treatment but suffers from a comparatively high instrumental effort due to combination with a conventional continuous wave treatment laser. In this paper, a simplified setup with a single pulsed laser at 10 kHz repetition rate is presented. The setup combines the instrumentation for treatment as well as temperature measurement and control in a single device. In order to compare the solely pulsed heating with continuous wave (cw) tissue heating, pulse energies of 4 µJ were applied with a repetition rate of 1 kHz to probe the temperature rise, respectively. With the same average laser power of 60 mW an almost identical temporal temperature course was retrieved in both irradiation modes as expected. The ability to reach and maintain a chosen aim temperature of 41 °C is demonstrated by means of model predictive control (MPC) and extended Kalman filtering at a the measurement rate of 250 Hz with an accuracy of less than ±0.1 °C. A major advantage of optimization-based control techniques like MPC is their capability of rigorously ensuring constraints, e.g., temperature limits, and thus, realizing a more reliable and secure temperature control during retinal laser irradiation.
{"title":"Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate","authors":"M. Mordmüller, V. Kleyman, M. Schaller, M. Wilson, D. Theisen-Kunde, K. Worthmann, M. Müller, R. Brinkmann","doi":"10.1515/aot-2021-0041","DOIUrl":"https://doi.org/10.1515/aot-2021-0041","url":null,"abstract":"Abstract Laser photocoagulation is one of the most frequently used treatment approaches in ophthalmology for a variety of retinal diseases. Depending on indication, treatment intensity varies from application of specific micro injuries down to gentle temperature increases without inducing cell damage. Especially for the latter, proper energy dosing is still a challenging issue, which mostly relies on the physician’s experience. Pulsed laser photoacoustic temperature measurement has already proven its ability for automated irradiation control during laser treatment but suffers from a comparatively high instrumental effort due to combination with a conventional continuous wave treatment laser. In this paper, a simplified setup with a single pulsed laser at 10 kHz repetition rate is presented. The setup combines the instrumentation for treatment as well as temperature measurement and control in a single device. In order to compare the solely pulsed heating with continuous wave (cw) tissue heating, pulse energies of 4 µJ were applied with a repetition rate of 1 kHz to probe the temperature rise, respectively. With the same average laser power of 60 mW an almost identical temporal temperature course was retrieved in both irradiation modes as expected. The ability to reach and maintain a chosen aim temperature of 41 °C is demonstrated by means of model predictive control (MPC) and extended Kalman filtering at a the measurement rate of 250 Hz with an accuracy of less than ±0.1 °C. A major advantage of optimization-based control techniques like MPC is their capability of rigorously ensuring constraints, e.g., temperature limits, and thus, realizing a more reliable and secure temperature control during retinal laser irradiation.","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":"0 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43547325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Arba-Mosquera, Luise Krüger, P. Naubereit, Simas Sobutas, Shwetabh Verma, Len Zheleznyak, W. Knox
Abstract A method to determine the optimum laser parameters for maximizing laser induced refractive index change (LIRIC) while avoiding exceeding the damage threshold for different materials with high water content (in particular, polymers such as hydrogels or the human cornea) is proposed. The model is based upon two previous independent models for LIRIC and for laser induced optical breakdown (LIOB) threshold combined in a simple manner. This work provides qualitative and quantitative estimates for the parameters leading to a maximum LIRIC effect below the threshold of LIOB.
{"title":"Analytical optimization of the laser induced refractive index change (LIRIC) process: maximizing LIRIC without reaching the damage threshold","authors":"S. Arba-Mosquera, Luise Krüger, P. Naubereit, Simas Sobutas, Shwetabh Verma, Len Zheleznyak, W. Knox","doi":"10.1515/aot-2021-0052","DOIUrl":"https://doi.org/10.1515/aot-2021-0052","url":null,"abstract":"Abstract A method to determine the optimum laser parameters for maximizing laser induced refractive index change (LIRIC) while avoiding exceeding the damage threshold for different materials with high water content (in particular, polymers such as hydrogels or the human cornea) is proposed. The model is based upon two previous independent models for LIRIC and for laser induced optical breakdown (LIOB) threshold combined in a simple manner. This work provides qualitative and quantitative estimates for the parameters leading to a maximum LIRIC effect below the threshold of LIOB.","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43931101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preview: ICO World Congress of optics and photonics 2022","authors":"A. Thoss","doi":"10.1515/aot-2021-0054","DOIUrl":"https://doi.org/10.1515/aot-2021-0054","url":null,"abstract":"","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":"10 1","pages":"353 - 359"},"PeriodicalIF":1.8,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44701143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract The combination of diffractive optical elements or spatial light modulators with fully synchronized galvo scanners offers a possibility to scale up machining processes with ultra-short pulses to several 100 W of average power with minimal thermal impact. This will be demonstrated with the high-rate applications multi-pulse drilling on the fly and material removal with special intensity distributions up to an average power of 162 W and a removal rate of 16.5 mm3/min. Based on the experimental results strategies to achieve drilling rates of several 10,000 holes/s or removal rates of multiple 10 mm3/min will be discussed.
{"title":"High-rate laser processing with ultrashort laser pulses by combination of diffractive elements with synchronized galvo scanning","authors":"M. Gafner, S. Remund, M. Chaja, B. Neuenschwander","doi":"10.1515/aot-2021-0035","DOIUrl":"https://doi.org/10.1515/aot-2021-0035","url":null,"abstract":"Abstract The combination of diffractive optical elements or spatial light modulators with fully synchronized galvo scanners offers a possibility to scale up machining processes with ultra-short pulses to several 100 W of average power with minimal thermal impact. This will be demonstrated with the high-rate applications multi-pulse drilling on the fly and material removal with special intensity distributions up to an average power of 162 W and a removal rate of 16.5 mm3/min. Based on the experimental results strategies to achieve drilling rates of several 10,000 holes/s or removal rates of multiple 10 mm3/min will be discussed.","PeriodicalId":46010,"journal":{"name":"Advanced Optical Technologies","volume":"10 1","pages":"333 - 352"},"PeriodicalIF":1.8,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48972113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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