Dynamic axial crushing tests were performed on C-section carbon fiber reinforced polymer (CFRP) composite stanchions used in sub-cargo area of aircraft to evaluate their dynamic response under high-speed axial crushing load. A numerical model based on the continuum damage mechanics (CDM) was developed, with calculated failure modes and crushing loads closely matching experimental results, validating the model’s accuracy and reliability. The influence of equivalent axial stiffness and lay-up sequence on the crushing failure modes and energy absorption characteristics of the stanchions was investigated. A mathematical relationship among the specific energy absorption (SEA), average crushing load and equivalent axial stiffness was fitted. The results showed that, compared to single lay-ups, hybrid lay-up configurations exhibited superior structural stability and energy absorption performance. In particular, lay-up configurations with higher equivalent axial stiffness significantly enhanced both the SEA and average crushing load. Furthermore, when the equivalent axial stiffness was held constant, variations in lay-up sequence had a relatively minor effect on the energy absorption characteristics. However, if the axial stiffness of the outermost plies was significantly reduced by consecutively placing 90° plies on the outermost plies, the axial stability of the stanchion deteriorated rapidly, leading to a pronounced decrease in its energy absorption performance.