European Archives of Paediatric Dentistry最新文献

Purpose: To review the current evidence on the association between salivary protein profile and dental caries in children during mixed dentition stage.

Methods: This systematic review followed the PRISMA 2020 guidelines. Searches were run in PubMed, Scopus and Embase along with gray literature. The searches were limited to studies on humans, published from inception to February 2024. Observational studies exploring correlations between salivary proteins and caries in children during mixed dentition (6-13 years) were included. The methodological quality of included studies was analyzed independently by two reviewers using the Joanna Briggs checklist and Newcastle-Ottawa scale, respectively followed by a qualitative synthesis.

Results: A total of 17 primary studies were included. The studies recruited 1,330 subjects including 612 caries-active and 505 caries-free subjects. The total protein content was higher in caries-active subjects. Among the glycoproteins, IgA and MUC5B were higher in caries-free subjects while the levels of MUC7 were lower in the caries-free group. Antimicrobial peptides and proteinase-3 levels were also higher in caries-free subjects. Contradictory findings were reported for the association of α- amylase and carbonic anhydrase with caries status. The included studies were categorized as good quality (n = 4), fair quality (n = 12) and poor quality (n = 1).

Conclusion: Based on fair-quality studies included in this review and within its limitations, the findings revealed that salivary proteins may be associated with susceptibility to dental caries in mixed dentition. Total salivary proteins are upregulated in caries-active subjects while salivary IgA, antimicrobial peptides and proteinase-3 are increased in caries-free subjects.

Systematic review registration: The study protocol was registered in PROSPERO (registration number CRD42024517374).

Purpose: The use of cone-beam computed tomographies (CBCT) in orthodontics and pediatric dentistry is constantly increasing. The aim of this systematic review was to critically appraise and summarize evidence from clinical studies on the prevalence of incidental findings from CBCTs of children and adolescents.

Methods: Systematic literature searches without restrictions were undertaken in eight databases from inception up to March 2024 for studies reporting on incidental findings from CBCT images of children and adolescents. After duplicate study selection, data extraction, and risk of bias assessment with a custom tool based on the Joanna Briggs institute's tool for prevalence studies, qualitative (narrative) data synthesis was performed.

Results: Ten studies covering a total of 1818 patients (48.5% male; average age 12.3 years) were included. The prevalence of incidental findings ranged from 0.4 to 80.3%, but high heterogeneity was seen between studies (I² = 99%). Incidental findings were most often related to airways (63.7%), followed by bone (23.6%), teeth (19.2), spine (26.2) and temporomandibular joint (3.8%). However, several methodological issues existed with included studies (incomplete reporting of patient- or CBCT-related details, incomplete categorization and reporting on the severity of findings, small sample sizes, and research transparency issues).

Conclusion: Evidence indicates that incidental findings can be often found in the CBCTs of child and adolescent patients. However, when a CBCT image is justified for children or adolescents, it should be adequately assessed for incidental findings by either a specialist oral and maxillofacial radiologist or a dentist with appropriate training and experience.

Aim: This prospective clinical study aimed to clinically investigate the efficiency of (GIC) glass-ionomer cement application (Ionostar Plus + Easy Glaze, VOCO) in reducing hypersensitivity in permanent molars affected by molar incisor hypomineralisation when assessed immediately (15 min) and 12 weeks after its application.

Materials and methods: Children with at least one hypersensitive MIH-affected permanent molar (MIH-TNI-3 or 4). The pre-treatment status was evaluated and only included if they did not receive a tooth-specific in-office desensitizing treatment within one month. Clinical pain assessments were performed using the schiff score air sensitivity scale (SCASS) and Wong-baker faces Scale (WBFS).

Results: This study involved 25 participants (mean age 8.6 ± 1.85 years) with 43 hypersensitive MIH-molars of which about half were SCASS 3 (n = 24, 55.8%) and SCASS 2 (n = 19, 44.2%). Regarding hypersensitivity, the reported mean SCASS score reduced significantly from 2.56 (± 0.50) at baseline to 1.14 (± 0.96) after 15 min of GIC sealant application and even further to 0.71 (± 0.89) after 12 weeks (P < 0.001, Paired t test). Similarly, reported WBFS scores also significantly reduced from 5.81 (± 2.50; Range = 2-10) at baseline to 2.88 (± 2.31; Range = 0-10) after 15 min and to 2.95 (± 2.17) after 12 weeks, respectively (P < 0.001, Paired t test). The mean reduction in SCASS scores was 1.3 (± 0.6) and 1.4 (± 1.0) for baseline SCASS 2 vs. 3, respectively.

Conclusion: GIC coverage is effective in providing clear instant relief from hypersensitivity in MIH molars in schoolchildren, which improves even further over a period of 12 weeks.

Purpose: This systematic review aims to consolidate existing genetic and clinical data on non-syndromic dentinogenesis imperfecta (DI) to enhance understanding of its etiology.

Methods: Electronic databases were searched for genetic familial linkage studies published in English without time restrictions. Genetic familial linkage studies that reported cases of Shield's classifications: DI-II, DI-III or DD-II were included. After removing duplicates and excluding non-eligible articles, two reviewers screened relevant articles independently, followed by data extraction.

Results: The systematic search identified 3475 articles, with 135 suitable for full-text review and a final 41 that met inclusion criteria. Within this set of studies, 10 conducted a histopathologic examination of teeth from affected participants. DSPP mutations were the most frequently reported, with 59 documented mutations. Four studies identified mutations in COL1A1 and COL1A2, revealing non-syndromic DI cases, predominantly in individuals of Asian descent. Histopathological analysis of affected teeth showed variations in pulp chamber size, dentinal tubule irregularities, enamel malformations, and mineral density reductions, depending on DI phenotype.

Conclusions: This review consolidates genetic and clinical data to advance the understanding of non-syndromic DI. It highlights the role of DSPP, COL1A1 and COL1A2 and the potential involvement of other genes, emphasizing the effectiveness of whole-exome sequencing in identifying causative mutations.

Purpose: People with sensory impairments (SI) face unique challenges in out-of-home care, especially in oral health (OH) care, compared to the general population. Various assistive technologies (ATs) and media are used to influence OH behaviors and outcomes for individuals with SI. This systematic review (SR) aimed to identify the types of ATs and assess their effectiveness for individuals with SI.

Methods: A comprehensive search strategy was applied across Scopus, PubMed, Cochrane Library, ProQuest, and Scopus databases, using expert-validated keywords, with manual searches for relevant articles published from June 2013 to June 2023. The SR followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible studies focused on the use of ATs as OH education tools for individuals with SI and assessed their impact on OH behavior and status.

Results: Eighteen of the 1298 identified studies were included in the data synthesis. ATs, such as images, software, multimedia, audio, video, audio-tactile performance, and combination methods, were effective for OH care in individuals with SI. However, this SR limitations include study heterogeneity in sample sizes, intervention types, and outcomes, as well as the exclusion of non-English studies.

Conclusions: Oral health education using a combination of video training and audio-tactile performance is particularly effective for individuals with SI, engaging multiple senses for learning. Future research should focus on standardizing methodologies and incorporating larger sample sizes to enhance the efficacy of these technologies in improving OH care for individuals with SI. PROSPERO REG. NO.: CRD42023485523.

Purpose: Identifying factors that disrupt cooperation during radiographic examination, such as dental fear and the gag reflex, is crucial for achieving optimal radiographic outcomes. The aim of the present study is to evaluate the levels of dental fear and cooperation amongst children aged 4-9 years undergoing intraoral radiographic examination at different stages of dental treatment. It also investigates the impact of the gag reflex on children's behaviour during intraoral radiographic examination.

Methods: A total of 89 children with no prior dental experience were randomly divided into two groups (G1, G2). Children in G1 underwent radiographic examination during their first dental visit, whilst children in G2 underwent the same after the completion of dental prophylaxis at their second visit. Variables assessed included dental fear, gagging and behaviour during radiographic examination. Multivariate logistic and linear regression analysis were performed to assess the variables that have an impact on behaviour during radiographic examination and on dental fear, respectively.

Results: Children in G2 were more likely to exhibit better behaviour during radiographic examination than G1children (OR: 4.709, p value = 0.036). In addition, G1 children demonstrated a greater increase of CFSS-DS score compared to G2 children (β = - 0.698, p value = 0.001) after the second appointment. Gagging during radiographic examination was significantly associated with lower Frankl score during the examination (p = 0.015).

Conclusion: Gradual exposure to radiographic examination may significantly enhance children's cooperation during the procedure and confine the progression of dental fear. In contrast, the presence of a gag reflex can compromise patient's cooperation during intraoral radiographic assessment.

Purpose: Optical properties of recent aesthetic restorative materials must maintain an acceptable appearance throughout their functional lifetime. This study aimed to assess the changes in translucency and colour of recent resin-based restorative materials after exposure to beverages commonly consumed by children.

Methods: An experimental in-vitro study on 48 discs specimens prepared from; Group I: Filtek Z250 XT (Nanohybrid), Group II: Cention N (Alkasite bulkfill), and Group III: SDR flow Plus (Flowable bulkfill). The prepared disc specimens were randomly assigned into 4 subgroups (n = 12) according to the immersion solution: Subgroup A (control): distilled water, B: Coca-Cola, C: chocolate milk, and D: Orange juice. Translucency and colour measurements were done before immersion (baseline) and on day 30 of exposure. Statistical analysis involved Two Way Repeated Measures ANOVA and Kruskal-Wallis test.

Results: The statistical analysis revealed that the restorative material, immersion time, and immersion solution had a significant effect on the change in translucency (p < 0.0001*, p < 0.0001*, p = 0.001*, respectively). Regarding colour changes, different immersion solutions had a statistically significant effect on Filtek Z250 XT and Cention N (p < 0.0001*). Distilled water and Coca-Cola were found to have a significant effect on colour change for all restorative materials investigated (p < 0.0001*, p = 0.003*).

Conclusion: the optical properties of resin-based restorative materials used in paediatric dentistry were notably affected by prolonged exposure to beverages commonly consumed by children.