Pub Date : 2022-07-01DOI: 10.1177/14744740221110584
Jacob Saindon
{"title":"Book review: Patricia Stuelke, The Ruse of Repair: US Neoliberal Empire and the Turn From Critique","authors":"Jacob Saindon","doi":"10.1177/14744740221110584","DOIUrl":"https://doi.org/10.1177/14744740221110584","url":null,"abstract":"","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"333 - 334"},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45523811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.1177/14744740221110579
Joshua Falcon
Geographical analyses of posthuman thought have called for the need to develop a critical form of posthumanism that neither rehashes the pitfalls of humanism, nor promulgates a universalized and ungrounded subject position. This article demonstrates how recent advances in critical posthumanism work to address the limitations of posthuman thought by offering a unified philosophical framework that situates knowledge claims and reimagines human subjectivity and human-nonhuman relations. Critical posthumanism not only synthesizes several of the political, methodological, and philosophical strands of posthuman thought that geographers and philosophers have drawn out, but it also foregrounds an affirmative ethico-political ethos toward a historical moment characterized by socioecological injustices, intersectional inequalities, and advanced capitalist economic systems. By separating itself from transhumanist and epochal forms of posthumanism, critical posthumanism offers cultural geographers concentrating on human-nature relations a more philosophically rigorous, socially accountable, and critical way of approaching the stakes involved in posthumanist discussions.
{"title":"Toward a critical posthuman geography","authors":"Joshua Falcon","doi":"10.1177/14744740221110579","DOIUrl":"https://doi.org/10.1177/14744740221110579","url":null,"abstract":"Geographical analyses of posthuman thought have called for the need to develop a critical form of posthumanism that neither rehashes the pitfalls of humanism, nor promulgates a universalized and ungrounded subject position. This article demonstrates how recent advances in critical posthumanism work to address the limitations of posthuman thought by offering a unified philosophical framework that situates knowledge claims and reimagines human subjectivity and human-nonhuman relations. Critical posthumanism not only synthesizes several of the political, methodological, and philosophical strands of posthuman thought that geographers and philosophers have drawn out, but it also foregrounds an affirmative ethico-political ethos toward a historical moment characterized by socioecological injustices, intersectional inequalities, and advanced capitalist economic systems. By separating itself from transhumanist and epochal forms of posthumanism, critical posthumanism offers cultural geographers concentrating on human-nature relations a more philosophically rigorous, socially accountable, and critical way of approaching the stakes involved in posthumanist discussions.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"19 - 34"},"PeriodicalIF":1.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41828139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-28DOI: 10.1177/14744740221102905
Wesley Aelbrecht
Much has been written in recent years about ruins and photography and especially so in the context of Detroit’s declining urban landscape. Numerous books present us with beautiful ruined buildings and landscapes, and further explanations why we might be drawn to images of decay. While some claim that ruin imagery triggers a form of resistance to the forces of capitalism, others stand critical to the beautification of ruins by arguing that such imagery removes viewers from any reflection on what causes ruins. Detroit’s new saviour Dan Gilbert is one of those ruin detractors who blames Detroit’s image as the poster child of ruin photography for all failed investments. This paper focusses on these image battles in the construction of a city’s place identity and argues for an understanding of ruin photographs as performance. Instead of offering a trace of an object once in front of the camera, I investigate how a collection of forgotten photo-installations curated by Detroit’s Urban Center for Photography gesture performatively to the ongoing event demolished by neglect whereby buildings are intentionally left to rot for profitable real estate development. Strategies of advertisement campaigns, it will be shown, are appropriated to make such live gestures. Investigating the doing aspect or force of ruin photographs contributes to cultural geography’s recent concerns around the potential ‘force of representations: their capacities to affect and effect’ and as such moves away from one of the central tasks of cultural geography, namely its focus on what representations mean. The spectre of Detroit’s image battle ultimately should provide us with questions about the construction of a city’s identity through visual documents and enable us to question the mechanism of neoliberal urban planning and governance.
{"title":"Detroit in memoriam: urban imaginaries and the spectre of demolished by neglect in performative photo-installations","authors":"Wesley Aelbrecht","doi":"10.1177/14744740221102905","DOIUrl":"https://doi.org/10.1177/14744740221102905","url":null,"abstract":"Much has been written in recent years about ruins and photography and especially so in the context of Detroit’s declining urban landscape. Numerous books present us with beautiful ruined buildings and landscapes, and further explanations why we might be drawn to images of decay. While some claim that ruin imagery triggers a form of resistance to the forces of capitalism, others stand critical to the beautification of ruins by arguing that such imagery removes viewers from any reflection on what causes ruins. Detroit’s new saviour Dan Gilbert is one of those ruin detractors who blames Detroit’s image as the poster child of ruin photography for all failed investments. This paper focusses on these image battles in the construction of a city’s place identity and argues for an understanding of ruin photographs as performance. Instead of offering a trace of an object once in front of the camera, I investigate how a collection of forgotten photo-installations curated by Detroit’s Urban Center for Photography gesture performatively to the ongoing event demolished by neglect whereby buildings are intentionally left to rot for profitable real estate development. Strategies of advertisement campaigns, it will be shown, are appropriated to make such live gestures. Investigating the doing aspect or force of ruin photographs contributes to cultural geography’s recent concerns around the potential ‘force of representations: their capacities to affect and effect’ and as such moves away from one of the central tasks of cultural geography, namely its focus on what representations mean. The spectre of Detroit’s image battle ultimately should provide us with questions about the construction of a city’s identity through visual documents and enable us to question the mechanism of neoliberal urban planning and governance.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"239 - 258"},"PeriodicalIF":1.6,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48122078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-22DOI: 10.1177/14744740221107091
F. Neyrat
of the book – Engelmann is no distant narrator drily reporting on research, we follow her progress as the research develops and she becomes ever more central to the Saraceno project, from observer ethnographer, to active participant and member of Studio Tomás Saraceno. In her account of being lifted in the air by a sculpture, we feel there with her; equally we feel a sense of deflation – both physical and emotional – as a launch on a cold Berlin airfield fails to take off. This embodied situated approach does not diminish the sense of research rigor, which is situated on the cusp of geography and art practice drawing on literature across the arts, humanities, social, and environmental sciences. As such, Sensing Art in the Atmosphere will be relevant to a wide range of researchers within these fields, as well as a wider interdisciplinary community around sociology, mobilities studies, and the geohumanities. The objective is less to examine how the artworks function, or what is gained within art, but to reflect upon impact and significance of the aerosolar arts as a method within a wider cultural milieu of social sciences and humanities. It offers a call to arms to establish a new field of ‘elemental geohumanities’ and to embrace the potential of the arts to contribute to geohumanties research.
{"title":"Book Review: Planetary Social Thought: The Anthropocene Challenge to the Social Sciences","authors":"F. Neyrat","doi":"10.1177/14744740221107091","DOIUrl":"https://doi.org/10.1177/14744740221107091","url":null,"abstract":"of the book – Engelmann is no distant narrator drily reporting on research, we follow her progress as the research develops and she becomes ever more central to the Saraceno project, from observer ethnographer, to active participant and member of Studio Tomás Saraceno. In her account of being lifted in the air by a sculpture, we feel there with her; equally we feel a sense of deflation – both physical and emotional – as a launch on a cold Berlin airfield fails to take off. This embodied situated approach does not diminish the sense of research rigor, which is situated on the cusp of geography and art practice drawing on literature across the arts, humanities, social, and environmental sciences. As such, Sensing Art in the Atmosphere will be relevant to a wide range of researchers within these fields, as well as a wider interdisciplinary community around sociology, mobilities studies, and the geohumanities. The objective is less to examine how the artworks function, or what is gained within art, but to reflect upon impact and significance of the aerosolar arts as a method within a wider cultural milieu of social sciences and humanities. It offers a call to arms to establish a new field of ‘elemental geohumanities’ and to embrace the potential of the arts to contribute to geohumanties research.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"159 - 160"},"PeriodicalIF":1.6,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45964135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.1177/14744740221102907
Rebekah Fox, Nickie Charles, Harriet Smith, M. Miele
Based upon a multi-species ethnography of companion dog training in the UK, this paper examines the training class as a site of inter-species communication through which dogs and their humans are mutually affected and transformed. We argue that dog training represents an important form of multi-species learning in which participants (human trainer, trainee and canine) shape one another, jointly if asymmetrically, through the performance of particular tasks and challenges. Successful training requires ‘attunement’ to the haptic and sensory experiences of another species and the creation of shared embodied languages through which relationships of trust and reciprocity are formed. Responding to calls for less human-centred methods we examine the possibilities of visual and ethnographic methods for capturing the ‘animal’s point of view’ and explore how deep ethnographic involvement of the researcher’s own body can draw attention to the everyday complexities of embodied inter-species communication. We consider the importance of our own embodied learning in decentring the human in the research process, engendering a corporeal understanding of the multi-sensory nature of inter-species interaction and transforming ourselves in the process. Through the use of ethnographic vignettes, photos and video stills we highlight the importance of body language, sound, touch, smell and training atmospheres in the creation of shared knowledges. In doing so we explore the possibilities of such methods for evoking the affective dimensions of human-canine interactions and attending to the complex and multiple actors and sensibilities which comprise multi-species training relationships.
{"title":"‘Imagine you are a Dog’: embodied learning in multi-species research","authors":"Rebekah Fox, Nickie Charles, Harriet Smith, M. Miele","doi":"10.1177/14744740221102907","DOIUrl":"https://doi.org/10.1177/14744740221102907","url":null,"abstract":"Based upon a multi-species ethnography of companion dog training in the UK, this paper examines the training class as a site of inter-species communication through which dogs and their humans are mutually affected and transformed. We argue that dog training represents an important form of multi-species learning in which participants (human trainer, trainee and canine) shape one another, jointly if asymmetrically, through the performance of particular tasks and challenges. Successful training requires ‘attunement’ to the haptic and sensory experiences of another species and the creation of shared embodied languages through which relationships of trust and reciprocity are formed. Responding to calls for less human-centred methods we examine the possibilities of visual and ethnographic methods for capturing the ‘animal’s point of view’ and explore how deep ethnographic involvement of the researcher’s own body can draw attention to the everyday complexities of embodied inter-species communication. We consider the importance of our own embodied learning in decentring the human in the research process, engendering a corporeal understanding of the multi-sensory nature of inter-species interaction and transforming ourselves in the process. Through the use of ethnographic vignettes, photos and video stills we highlight the importance of body language, sound, touch, smell and training atmospheres in the creation of shared knowledges. In doing so we explore the possibilities of such methods for evoking the affective dimensions of human-canine interactions and attending to the complex and multiple actors and sensibilities which comprise multi-species training relationships.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"429 - 452"},"PeriodicalIF":1.6,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42435046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.1177/14744740221104485
Alexandra Halligey
Through a close reading of Zadie Smith’s portrayal of the character Keisha/Natalie’s voice and relationship to voice in the novel NW, this article considers how people’s speaking, sounding voices are both emplaced (coming from, made by place) and are key place-making acts. This paper argues for how analysing sound in literature might serve sonic geographic interest in the ‘whole’ voice, with all sound’s representational and more-than representational elements. Through its fictional and poetic expressivity the literary offers propositional perspectives on experiences of sound and its material and affectual role in our world making. From this departure point, the paper proceeds to consider the entangled issues of place and identity politics in NW, motivating that a reading or ‘listening’ in terms of voice might offer valuable insights into these concerns. Attending to three moments in NW centred around the character Keisha/Natalie, the paper argues for how human’s speaking voices might enact and contain the complex difficulties in the co-construction of place and personal identity.
{"title":"Emplaced sounding: voice, identity and place in Zadie Smith’s NW","authors":"Alexandra Halligey","doi":"10.1177/14744740221104485","DOIUrl":"https://doi.org/10.1177/14744740221104485","url":null,"abstract":"Through a close reading of Zadie Smith’s portrayal of the character Keisha/Natalie’s voice and relationship to voice in the novel NW, this article considers how people’s speaking, sounding voices are both emplaced (coming from, made by place) and are key place-making acts. This paper argues for how analysing sound in literature might serve sonic geographic interest in the ‘whole’ voice, with all sound’s representational and more-than representational elements. Through its fictional and poetic expressivity the literary offers propositional perspectives on experiences of sound and its material and affectual role in our world making. From this departure point, the paper proceeds to consider the entangled issues of place and identity politics in NW, motivating that a reading or ‘listening’ in terms of voice might offer valuable insights into these concerns. Attending to three moments in NW centred around the character Keisha/Natalie, the paper argues for how human’s speaking voices might enact and contain the complex difficulties in the co-construction of place and personal identity.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"29 1","pages":"499 - 513"},"PeriodicalIF":1.6,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44231779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.1177/14744740221104486
R. Saunders
Television – as a form of representation, a space of affect, and an instrument of identity production – is a growing force in shaping perceptions of and views on international immigration. While geographers have examined the ways in which films, documentaries, and social media engage with the so-called ‘migrant crisis’ in Europe, there has been little work on fictional TV series as a force in world-building and place-making against the spectre of ‘unchecked migration’. Building on recent research on televisual interventions into the issues of migration, (b)orders, and securitisation, this article interrogates HBO Europe’s Norwegian-language sf series Beforeigners. With a focus on fantastical constructions of spatiality against temporality, the primary focus of this article is on the ways in which near-future science fiction engages with ontological insecurities around integration, xenophobia, and territorial belonging. This is accomplished by engaging the ‘temporal turn’ in cultural geography, which is increasingly focused on linking time, space, and migrant lives/bodies. Recognising TV series’ contributions to cultural, social, and political transformations that are of geographical significance, this essay seeks to expand and complicate scholarship on the suasive power of migrant representation on the small screen.
{"title":"Out of time/in place: Norwegianness, ‘immigration’, and spatial belonging in Beforeigners","authors":"R. Saunders","doi":"10.1177/14744740221104486","DOIUrl":"https://doi.org/10.1177/14744740221104486","url":null,"abstract":"Television – as a form of representation, a space of affect, and an instrument of identity production – is a growing force in shaping perceptions of and views on international immigration. While geographers have examined the ways in which films, documentaries, and social media engage with the so-called ‘migrant crisis’ in Europe, there has been little work on fictional TV series as a force in world-building and place-making against the spectre of ‘unchecked migration’. Building on recent research on televisual interventions into the issues of migration, (b)orders, and securitisation, this article interrogates HBO Europe’s Norwegian-language sf series Beforeigners. With a focus on fantastical constructions of spatiality against temporality, the primary focus of this article is on the ways in which near-future science fiction engages with ontological insecurities around integration, xenophobia, and territorial belonging. This is accomplished by engaging the ‘temporal turn’ in cultural geography, which is increasingly focused on linking time, space, and migrant lives/bodies. Recognising TV series’ contributions to cultural, social, and political transformations that are of geographical significance, this essay seeks to expand and complicate scholarship on the suasive power of migrant representation on the small screen.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44664177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.1177/14744740221100838
Maarja Kaaristo, Francesco Visentin
This article extends our understanding of inland waterways by theorising the temporary absences of water in canals and rivers as possibilities for action, that is, affordances. The interplay of temporary absence and presence of water in the inland waterways provides a range of potentialities for various activities and practices. Affordance theory can help us to further theorise material absences and position them as important elements of performing, practicing and interpreting place. We show how temporary absence of water can create spatial, historical and communicative affordances, affording the movement of boats, revealing and recreating the past and raising environmental awareness. The paper is based on semi-ethnographic research on the rivers and canals in the United Kingdom and Italy, featuring document analysis, participant observation and semi-structured interviews with various waterway users.
{"title":"Absence as an affordance: thinking with(out) water on the inland waterways","authors":"Maarja Kaaristo, Francesco Visentin","doi":"10.1177/14744740221100838","DOIUrl":"https://doi.org/10.1177/14744740221100838","url":null,"abstract":"This article extends our understanding of inland waterways by theorising the temporary absences of water in canals and rivers as possibilities for action, that is, affordances. The interplay of temporary absence and presence of water in the inland waterways provides a range of potentialities for various activities and practices. Affordance theory can help us to further theorise material absences and position them as important elements of performing, practicing and interpreting place. We show how temporary absence of water can create spatial, historical and communicative affordances, affording the movement of boats, revealing and recreating the past and raising environmental awareness. The paper is based on semi-ethnographic research on the rivers and canals in the United Kingdom and Italy, featuring document analysis, participant observation and semi-structured interviews with various waterway users.","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"87 - 102"},"PeriodicalIF":1.6,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45691793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yifan Wang, Adeline Cuggia, Yen-I Chen, Josée Parent, Agatha Stanek, Robert E Denroche, Amy Zhang, Robert C Grant, Céline Domecq, Bryn Golesworthy, Chaya Shwaartz, Ayelet Borgida, Spring Holter, Julie M Wilson, George Chong, Grainne M O'Kane, Jennifer J Knox, Sandra E Fischer, Steven Gallinger, Zu-Hua Gao, William D Foulkes, Kevin A Waschke, George Zogopoulos
Background: Individuals with a family history of pancreatic adenocarcinoma (PC) or with a germline mutation in a PC susceptibility gene are at increased risk of developing PC. These high-risk individuals (HRIs) may benefit from PC surveillance.
Methods: A PC surveillance program was developed to evaluate the detection of premalignant lesions and early-stage PCs using biannual imaging and to determine whether locally advanced or metastatic PCs develop despite biannual surveillance. From January 2013 to April 2020, asymptomatic HRIs were enrolled and followed with alternating MRI and endoscopic ultrasound every 6 months.
Results: Of 75 HRIs, 43 (57.3%) had a germline mutation in a PC susceptibility gene and 32 (42.7%) had a familial pancreatic cancer (FPC) pedigree. Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) were identified in 26 individuals (34.7%), but only 2 developed progressive lesions. One patient with Peutz-Jeghers syndrome (PJS) developed locally advanced PC arising from a BD-IPMN. Whole-genome sequencing of this patient's PC and of a second patient with PJS-associated PC from the same kindred revealed biallelic inactivation of STK11 in a KRAS-independent manner. A review of 3,853 patients from 2 PC registries identified an additional patient with PJS-associated PC. All 3 patients with PJS developed advanced PC consistent with the malignant transformation of an underlying BD-IPMN in <6 months. The other surveillance patient with a progressive lesion had FPC and underwent resection of a mixed-type IPMN that harbored polyclonal KRAS mutations.
Conclusions: PC surveillance identifies a high prevalence of BD-IPMNs in HRIs. Patients with PJS with BD-IPMNs may be at risk for accelerated malignant transformation.
背景：有胰腺腺癌（PC）家族史或 PC 易感基因有种系突变的人患 PC 的风险更高。这些高危人群（HRIs）可能会从 PC 监测中受益：方法：制定了一项 PC 监测计划，以评估通过半年一次的成像检测发现恶性前病变和早期 PC 的情况，并确定尽管进行了半年一次的监测，但是否仍会出现局部晚期或转移性 PC。从 2013 年 1 月至 2020 年 4 月，无症状的 HRIs 被纳入该计划，并每 6 个月交替接受一次核磁共振成像和内窥镜超声检查：75名HRI中，43人（57.3%）有PC易感基因的种系突变，32人（42.7%）有家族性胰腺癌（FPC）血统。26人（34.7%）中发现了分支导管内乳头状粘液瘤（BD-IPMNs），但只有2人发展为进展性病变。一名患有 Peutz-Jeghers 综合征（PJS）的患者出现了由 BD-IPMN 引起的局部晚期 PC。对该患者的 PC 和来自同一血统的另一名 PJS 相关 PC 患者进行的全基因组测序发现，STK11 以一种与 KRAS 无关的方式发生了双偶联失活。对来自 2 个 PC 登记处的 3,853 名患者进行复查后，又发现了一名 PJS 相关 PC 患者。这 3 位 PJS 患者均在 6 个月内发展为晚期 PC，与潜在的 BD-IPMN 恶性转化一致。另一名有进展性病变的监测患者患有FPC，并接受了混合型IPMN切除术，该IPMN携带多克隆KRAS突变：结论：PC 监测确定了 BD-IPMN 在 HRI 中的高患病率。结论：PC 监测发现，BD-IPMNs 在 HRIs 中的发病率很高，伴有 BD-IPMNs 的 PJS 患者可能有加速恶性转化的风险。
{"title":"Is Biannual Surveillance for Pancreatic Cancer Sufficient in Individuals With Genetic Syndromes or Familial Pancreatic Cancer?","authors":"Yifan Wang, Adeline Cuggia, Yen-I Chen, Josée Parent, Agatha Stanek, Robert E Denroche, Amy Zhang, Robert C Grant, Céline Domecq, Bryn Golesworthy, Chaya Shwaartz, Ayelet Borgida, Spring Holter, Julie M Wilson, George Chong, Grainne M O'Kane, Jennifer J Knox, Sandra E Fischer, Steven Gallinger, Zu-Hua Gao, William D Foulkes, Kevin A Waschke, George Zogopoulos","doi":"10.6004/jnccn.2021.7107","DOIUrl":"10.6004/jnccn.2021.7107","url":null,"abstract":"<p><strong>Background: </strong>Individuals with a family history of pancreatic adenocarcinoma (PC) or with a germline mutation in a PC susceptibility gene are at increased risk of developing PC. These high-risk individuals (HRIs) may benefit from PC surveillance.</p><p><strong>Methods: </strong>A PC surveillance program was developed to evaluate the detection of premalignant lesions and early-stage PCs using biannual imaging and to determine whether locally advanced or metastatic PCs develop despite biannual surveillance. From January 2013 to April 2020, asymptomatic HRIs were enrolled and followed with alternating MRI and endoscopic ultrasound every 6 months.</p><p><strong>Results: </strong>Of 75 HRIs, 43 (57.3%) had a germline mutation in a PC susceptibility gene and 32 (42.7%) had a familial pancreatic cancer (FPC) pedigree. Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) were identified in 26 individuals (34.7%), but only 2 developed progressive lesions. One patient with Peutz-Jeghers syndrome (PJS) developed locally advanced PC arising from a BD-IPMN. Whole-genome sequencing of this patient's PC and of a second patient with PJS-associated PC from the same kindred revealed biallelic inactivation of STK11 in a KRAS-independent manner. A review of 3,853 patients from 2 PC registries identified an additional patient with PJS-associated PC. All 3 patients with PJS developed advanced PC consistent with the malignant transformation of an underlying BD-IPMN in <6 months. The other surveillance patient with a progressive lesion had FPC and underwent resection of a mixed-type IPMN that harbored polyclonal KRAS mutations.</p><p><strong>Conclusions: </strong>PC surveillance identifies a high prevalence of BD-IPMNs in HRIs. Patients with PJS with BD-IPMNs may be at risk for accelerated malignant transformation.</p>","PeriodicalId":47718,"journal":{"name":"Cultural Geographies","volume":"30 1","pages":"663-673.e12"},"PeriodicalIF":13.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79666436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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