Pub Date : 2022-12-01Epub Date: 2022-04-26DOI: 10.1007/s00262-022-03203-7
Yu Fujiwara, Nobuyuki Horita, Matthew Harrington, Ho Namkoong, Hirotaka Miyashita, Matthew D Galsky
Hepatotoxicity is a major immune-related adverse event that may become life-threatening. The impact of adding immune checkpoint blockade (ICB) to systemic therapy on the incidence of hepatotoxicity remains unknown. We performed a systematic review and meta-analysis to compare the incidence of hepatotoxicity among patients with cancer who received therapy with and without addition of ICB. PubMed, Embase, Web of Science, and Cochrane Library were searched to select phase 3 randomized controlled trials (RCTs) evaluating the effect of adding ICB to systemic therapy, placebo, or supportive care. The odds ratio (OR) of any grade and grade 3-5 hepatitis, elevations in aspartate aminotransferase (AST), and alanine aminotransferase (ALT) was pooled for meta-analysis. 43 RCTs with 28,905 participants were analyzed. Addition of ICB increased the incidence of hepatitis (any grade: OR, 2.13, 95% confidence interval [CI] 1.52-2.97, grade 3-5: OR, 2.66, 95% CI 1.72-4.11), elevated AST (any grade: OR, 2.16, 95% CI 1.73-2.70, grade 3-5: OR, 2.72, 95% CI 1.86-3.99), and elevated ALT (any grade: OR, 2.01, 95% CI 1.59-2.54, grade 3-5: OR, 2.40, 95% CI 1.62-3.55). Subgroup analysis based on the ICB mechanism revealed no significant heterogeneity among each mechanism for hepatitis (any Grade: I2 = 11.1%, p for heterogeneity = 0.32, grade 3-5: I2 = 0%, p = 0.48). Adding ICB to systemic therapy increases the incidence of hepatotoxicity regardless of the mechanism of ICB. Hepatotoxicity is common and vigilant monitoring of liver function is required during ICB therapy for patients with cancer.
{"title":"Incidence of hepatotoxicity associated with addition of immune checkpoint blockade to systemic solid tumor therapy: a meta-analysis of phase 3 randomized controlled trials.","authors":"Yu Fujiwara, Nobuyuki Horita, Matthew Harrington, Ho Namkoong, Hirotaka Miyashita, Matthew D Galsky","doi":"10.1007/s00262-022-03203-7","DOIUrl":"10.1007/s00262-022-03203-7","url":null,"abstract":"<p><p>Hepatotoxicity is a major immune-related adverse event that may become life-threatening. The impact of adding immune checkpoint blockade (ICB) to systemic therapy on the incidence of hepatotoxicity remains unknown. We performed a systematic review and meta-analysis to compare the incidence of hepatotoxicity among patients with cancer who received therapy with and without addition of ICB. PubMed, Embase, Web of Science, and Cochrane Library were searched to select phase 3 randomized controlled trials (RCTs) evaluating the effect of adding ICB to systemic therapy, placebo, or supportive care. The odds ratio (OR) of any grade and grade 3-5 hepatitis, elevations in aspartate aminotransferase (AST), and alanine aminotransferase (ALT) was pooled for meta-analysis. 43 RCTs with 28,905 participants were analyzed. Addition of ICB increased the incidence of hepatitis (any grade: OR, 2.13, 95% confidence interval [CI] 1.52-2.97, grade 3-5: OR, 2.66, 95% CI 1.72-4.11), elevated AST (any grade: OR, 2.16, 95% CI 1.73-2.70, grade 3-5: OR, 2.72, 95% CI 1.86-3.99), and elevated ALT (any grade: OR, 2.01, 95% CI 1.59-2.54, grade 3-5: OR, 2.40, 95% CI 1.62-3.55). Subgroup analysis based on the ICB mechanism revealed no significant heterogeneity among each mechanism for hepatitis (any Grade: I<sup>2</sup> = 11.1%, p for heterogeneity = 0.32, grade 3-5: I<sup>2</sup> = 0%, p = 0.48). Adding ICB to systemic therapy increases the incidence of hepatotoxicity regardless of the mechanism of ICB. Hepatotoxicity is common and vigilant monitoring of liver function is required during ICB therapy for patients with cancer.</p>","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"30 1","pages":"2837-2848"},"PeriodicalIF":5.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10992785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87716886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.1177/10464964221137524
Eija Vuorenmaa, Sanna Järvelä, M. Dindar, H. Järvenoja
This study explored sequential patterns in social interaction states for group-level regulation of learning during collaborative learning. The participants were secondary school students (N = 92) performing collaborative physics tasks. The videotaped sessions were analyzed regarding participation, social interaction, and group-level regulation types of co- and socially shared regulation. The results show that group-level regulation emerged most frequently in social interaction state that included cognitive and socioemotional interaction and whole-group participation, which also led to and followed regulation most frequently. The findings highlight the role of joint participation in social interactions for regulation of learning in collaborative group settings.
{"title":"Sequential Patterns in Social Interaction States for Regulation in Collaborative Learning","authors":"Eija Vuorenmaa, Sanna Järvelä, M. Dindar, H. Järvenoja","doi":"10.1177/10464964221137524","DOIUrl":"https://doi.org/10.1177/10464964221137524","url":null,"abstract":"This study explored sequential patterns in social interaction states for group-level regulation of learning during collaborative learning. The participants were secondary school students (N = 92) performing collaborative physics tasks. The videotaped sessions were analyzed regarding participation, social interaction, and group-level regulation types of co- and socially shared regulation. The results show that group-level regulation emerged most frequently in social interaction state that included cognitive and socioemotional interaction and whole-group participation, which also led to and followed regulation most frequently. The findings highlight the role of joint participation in social interactions for regulation of learning in collaborative group settings.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"54 1","pages":"512 - 550"},"PeriodicalIF":3.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48983917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-02DOI: 10.1177/10464964221132203
Eleni Georganta, Selina Stracke, Felix Brodbeck, K. Knipfer, C. Shawn Burke
Investigating the team adaptation process in two laboratory experiments (N = 144 teams, n = 504 participants), we found no benefits for teams with team adaptation experience (vs. without) nor for teams with external team adaptation experience (vs. with internal experience). Collective experience under routine and nonroutine conditions seems to provide teams with the resources to adapt. We further found that executing the team adaptation process did not always lead to high team performance; different team performance requirements might explain these findings. We discuss how our experimental findings can extend our understanding of team adaptation toward new boundary conditions.
{"title":"Shedding Light on Team Adaptation: Does Experience Matter?","authors":"Eleni Georganta, Selina Stracke, Felix Brodbeck, K. Knipfer, C. Shawn Burke","doi":"10.1177/10464964221132203","DOIUrl":"https://doi.org/10.1177/10464964221132203","url":null,"abstract":"Investigating the team adaptation process in two laboratory experiments (N = 144 teams, n = 504 participants), we found no benefits for teams with team adaptation experience (vs. without) nor for teams with external team adaptation experience (vs. with internal experience). Collective experience under routine and nonroutine conditions seems to provide teams with the resources to adapt. We further found that executing the team adaptation process did not always lead to high team performance; different team performance requirements might explain these findings. We discuss how our experimental findings can extend our understanding of team adaptation toward new boundary conditions.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"54 1","pages":"474 - 511"},"PeriodicalIF":3.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44285414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-20DOI: 10.1177/10464964221121349
H. Love, J. Cross, Bailey K. Fosdick, Elizabeth Tofany, Ellyn M. Dickmann
To solve complex 21st-century global challenges, universities must prepare students to be competent team members. This article presents results from analysis of data collected at a university in four types of undergraduate sociology classrooms using mixed-methods, including social network analysis, student reflections, and an alumni survey. Results showed that learning is a social process. Compared with traditional lecture, fixed teams, and interacting teams, opportunistic collaboration is the most effective structure in teaching team learning through fostering communication, support, and learning networks. Post-secondary education should endorse opportunistic collaboration learning practices to prepare students for workplace success in a global economy.
{"title":"Teaching Team Science: The Key to Addressing 21st Century Global Challenges","authors":"H. Love, J. Cross, Bailey K. Fosdick, Elizabeth Tofany, Ellyn M. Dickmann","doi":"10.1177/10464964221121349","DOIUrl":"https://doi.org/10.1177/10464964221121349","url":null,"abstract":"To solve complex 21st-century global challenges, universities must prepare students to be competent team members. This article presents results from analysis of data collected at a university in four types of undergraduate sociology classrooms using mixed-methods, including social network analysis, student reflections, and an alumni survey. Results showed that learning is a social process. Compared with traditional lecture, fixed teams, and interacting teams, opportunistic collaboration is the most effective structure in teaching team learning through fostering communication, support, and learning networks. Post-secondary education should endorse opportunistic collaboration learning practices to prepare students for workplace success in a global economy.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"54 1","pages":"396 - 427"},"PeriodicalIF":3.7,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48764295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.1177/10464964221127982
Trevor M. Spoelma, Tamanna Chauhan
Although team deviance is known to detract from team functioning, extant literature largely focuses on deviance that is independently enacted and directed internally toward other members. This relatively narrow focus poses limitations to the practical application of strategies to reduce the incidence and negative impact of team deviance. We offer a four-dimensional typology that takes into account features of team deviance that are important yet undertheorized: level of coordination and target membership. We use this typology to summarize current research, highlight the narratives on team deviance that underlie each dimension, and discuss how to advance the research domain.
{"title":"Expanding the Dimensionality of Team Deviance: An Organizing Framework and Review","authors":"Trevor M. Spoelma, Tamanna Chauhan","doi":"10.1177/10464964221127982","DOIUrl":"https://doi.org/10.1177/10464964221127982","url":null,"abstract":"Although team deviance is known to detract from team functioning, extant literature largely focuses on deviance that is independently enacted and directed internally toward other members. This relatively narrow focus poses limitations to the practical application of strategies to reduce the incidence and negative impact of team deviance. We offer a four-dimensional typology that takes into account features of team deviance that are important yet undertheorized: level of coordination and target membership. We use this typology to summarize current research, highlight the narratives on team deviance that underlie each dimension, and discuss how to advance the research domain.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"54 1","pages":"77 - 117"},"PeriodicalIF":3.7,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46607922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-05DOI: 10.1177/10464964221125717
Elwira A. Hałgas, Kyana H. J. van Eijndhoven, J. Gevers, Travis J. Wiltshire, Joyce H. D. M. Westerink, S. Rispens
Wearable technology enables collecting continuous in situ data from multiple people in various modalities, which can enhance team research and support, as the dynamic coupling of signals between interacting individuals (i.e., team coordination dynamics) is believed to reflect underlying processes and states of team functioning and performance. We conducted a systematic review on existing literature to evaluate the prospective use of wearable technology in research and practice. Using the IMOI framework as an organizing tool, our review revealed considerable support linking team coordination dynamics in different modalities to team functioning and performance, but also explicated the field’s nascent status.
{"title":"A Review of Using Wearable Technology to Assess Team Functioning and Performance","authors":"Elwira A. Hałgas, Kyana H. J. van Eijndhoven, J. Gevers, Travis J. Wiltshire, Joyce H. D. M. Westerink, S. Rispens","doi":"10.1177/10464964221125717","DOIUrl":"https://doi.org/10.1177/10464964221125717","url":null,"abstract":"Wearable technology enables collecting continuous in situ data from multiple people in various modalities, which can enhance team research and support, as the dynamic coupling of signals between interacting individuals (i.e., team coordination dynamics) is believed to reflect underlying processes and states of team functioning and performance. We conducted a systematic review on existing literature to evaluate the prospective use of wearable technology in research and practice. Using the IMOI framework as an organizing tool, our review revealed considerable support linking team coordination dynamics in different modalities to team functioning and performance, but also explicated the field’s nascent status.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"54 1","pages":"41 - 76"},"PeriodicalIF":3.7,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47501211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.1177/10464964211073590
Sanne A. van der Meer, N. Lehmann-Willenbrock, R. Delahaij, A. Homan
Despite their prevalence in daily teamwork, little is known about the influence of intrusions on teams. Therefore, the effect of intrusions on team interaction was investigated, focusing on relational communication. Three different theoretical perspectives regarding team interaction changes in response to a meeting intrusion are discussed. These perspectives were mapped onto fine-grained behavioral data from twelve teams (N = 4,627 sense units) by means of lag sequential analysis. Teams’ use of relational communication changed in several ways in response to the intrusion. While these changes fit best with one perspective (task-focused), several results also align with other perspectives.
{"title":"The Influence of Intrusions on Team Interaction: An Explorative Field Study","authors":"Sanne A. van der Meer, N. Lehmann-Willenbrock, R. Delahaij, A. Homan","doi":"10.1177/10464964211073590","DOIUrl":"https://doi.org/10.1177/10464964211073590","url":null,"abstract":"Despite their prevalence in daily teamwork, little is known about the influence of intrusions on teams. Therefore, the effect of intrusions on team interaction was investigated, focusing on relational communication. Three different theoretical perspectives regarding team interaction changes in response to a meeting intrusion are discussed. These perspectives were mapped onto fine-grained behavioral data from twelve teams (N = 4,627 sense units) by means of lag sequential analysis. Teams’ use of relational communication changed in several ways in response to the intrusion. While these changes fit best with one perspective (task-focused), several results also align with other perspectives.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"53 1","pages":"644 - 669"},"PeriodicalIF":3.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42414016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-25DOI: 10.1177/10464964221125521
{"title":"CALL FOR SUBMISSIONS 18th Annual Conference 20-22 July 2023","authors":"","doi":"10.1177/10464964221125521","DOIUrl":"https://doi.org/10.1177/10464964221125521","url":null,"abstract":"","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"53 1","pages":"926 - 927"},"PeriodicalIF":3.7,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47050903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-25DOI: 10.1177/10464964221125522
{"title":"CALL FOR PROPOSALS Small Group Research 2025 REVIEW ISSUE","authors":"","doi":"10.1177/10464964221125522","DOIUrl":"https://doi.org/10.1177/10464964221125522","url":null,"abstract":"","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"53 1","pages":"928 - 931"},"PeriodicalIF":3.7,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48092864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-09DOI: 10.1177/10464964221121273
Bård Fyhn, Henning Bang, Therese E Sverdrup, Vidar Schei
Team psychological safety, as a shared perception, is persistently found to be important for team performance. However, team members may not necessarily agree on the level of safety within the team. What happens when team members have dispersed perceptions of team psychological safety? Through a survey-based study involving 1,149 members of 160 management teams, we found that, not only is the level of team psychological safety positively related to team performance, but also that sharedness among team members (team psychological safety climate strength) moderates this relationship. The more team members agree on the level of team psychological safety, the stronger the effect of team psychological safety on team performance. Further, having at least one member who perceives the team as psychologically safe may lift team performance in a team of low psychological safety. We discuss theoretical and practical implications of looking beyond average levels of team psychological safety for building high-performing teams.
{"title":"Safe Among the Unsafe: Psychological Safety Climate Strength Matters for Team Performance","authors":"Bård Fyhn, Henning Bang, Therese E Sverdrup, Vidar Schei","doi":"10.1177/10464964221121273","DOIUrl":"https://doi.org/10.1177/10464964221121273","url":null,"abstract":"Team psychological safety, as a shared perception, is persistently found to be important for team performance. However, team members may not necessarily agree on the level of safety within the team. What happens when team members have dispersed perceptions of team psychological safety? Through a survey-based study involving 1,149 members of 160 management teams, we found that, not only is the level of team psychological safety positively related to team performance, but also that sharedness among team members (team psychological safety climate strength) moderates this relationship. The more team members agree on the level of team psychological safety, the stronger the effect of team psychological safety on team performance. Further, having at least one member who perceives the team as psychologically safe may lift team performance in a team of low psychological safety. We discuss theoretical and practical implications of looking beyond average levels of team psychological safety for building high-performing teams.","PeriodicalId":47912,"journal":{"name":"Small Group Research","volume":"54 1","pages":"439 - 473"},"PeriodicalIF":3.7,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44569710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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