首页 > 最新文献

Journal of Sport and Health Science最新文献

英文 中文
Iron deficiency, supplementation, and sports performance in female athletes: A systematic review. 女性运动员的铁缺乏症、补充剂和运动表现:系统综述。
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2024-11-12 DOI: 10.1016/j.jshs.2024.101009
Michael Pengelly, Kate Pumpa, David Bruce Pyne, Naroa Etxebarria

Background: Iron facilitates key biological functions underpinning sports performance, and up to 60% of female athletes experience iron deficiency. However, the effects of iron deficiency on sports performance in female athletes is unclear, as are the degree of benefits of iron supplementation (FeSup). This study characterizes the effects of iron deficiency and FeSup on sports performance in high-level female athletes.

Methods: Searches of the electronic databases MEDLINE, SPORTDiscus, Web of Science, Scopus, and CINAHL were performed in July 2023. Studies were included that evaluated the effects of iron deficiency or FeSup on sports performance in high-level (maximal oxygen uptake (VO2max) > 45 mL/kg/min, or trained > 5 h/week) iron deficient (ID) (serum ferritin (sFer) < 40 µg/L) female athletes. Studies were assessed using a modified Downs and Black Quality Assessment Checklist.

Results: A total of 23 studies comprising 669 athletes (age range: 13-47 years) across 16 sports were included in the review. Iron deficiency negatively affects endurance performance by 3%-4%. However, endurance performance improved by 2%-20% when ID athletes were treated with 100 mg/day of elemental iron for up to 56 days via oral supplementation, or bi-daily via parenteral administration over 8-10 days. ID non-anemic athletes with low sFer stores may be predisposed to reduced maximal aerobic capacity. However, maximal aerobic capacity improved by 6%-15% following 16 mg/day-100 mg/day of elemental iron for 36-126 days. Isokinetic strength and anaerobic power performance may be impeded (-23% to +4%) among ID athletes, but the effect of FeSup on anaerobic power varied markedly (-5% to +9%) following 100 mg/day of elemental iron over 42-56 days, or 100 mg of elemental iron bi-daily over 8-10 days. The quality of studies was moderate (77%), ranging from low (57%) to high (100%). Moststudies (n = 18) contained group sizes ≤ 20 athletes, thus limiting the likelihood of detecting significant effects (statistical power > 0.80).

Conclusion: High-level ID female athletes experience a negative impact on endurance performance, which can be improved by supplementing with ∼100 mg of elemental iron per day or bi-daily. The decrements in other performance parameters characterizing a range of sports coincide with the severity of iron deficiency.

背景:铁能促进支撑运动表现的关键生物功能,而多达 60% 的女运动员都会缺铁。然而,铁缺乏对女运动员运动表现的影响以及铁补充剂(FeSup)的益处尚不清楚。本研究描述了高水平女运动员缺铁和补铁对运动成绩的影响:方法:于 2023 年 7 月对 Medline、SPORTDiscus、Web of Science、Scopus 和 CINAHL 等电子数据库进行了检索。纳入了评估缺铁或铁超标对高水平(最大摄氧量 (VO2max) > 45 mL/kg/min,或训练时间 > 5 小时/周)缺铁(ID)(血清铁蛋白 (sFer) < 40 µg/L)女运动员运动表现影响的研究。研究采用修改后的唐斯和布莱克质量评估检查表进行评估:共有 23 项研究被纳入审查范围,涉及 16 个运动项目的 669 名运动员(年龄范围:13-47 岁)。缺铁对耐力表现的负面影响为 3%-4%。然而,如果通过口服补充 100 毫克/天的元素铁,或通过肠外给药 8-10 天的双日给药,ID 运动员的耐力表现可提高 2%-20%。sFer储存量低的ID非贫血运动员可能容易降低最大有氧运动能力。然而,在连续 36-126 天每天摄入 16-100 毫克元素铁后,最大有氧能力提高了 6%-15%。在 ID 运动员中,等速力量和无氧动力表现可能会受到阻碍(-23% 至 +4%),但在 42-56 天内每天摄入 100 毫克铁元素,或 8-10 天内每天摄入 100 毫克铁元素后,铁超标对无氧动力的影响明显不同(-5% 至 +9%)。研究质量为中等(77%),从低(57%)到高(100%)不等。大多数研究(n = 18)中的运动员人数不超过 20 人,因此限制了发现显著效果的可能性(统计功率 > 0.80):结论:高水平 ID 女性运动员的耐力表现会受到负面影响,通过每天或每两天补充 100 毫克铁元素可以改善这种情况。一系列运动的其他性能参数的下降与缺铁的严重程度相吻合。
{"title":"Iron deficiency, supplementation, and sports performance in female athletes: A systematic review.","authors":"Michael Pengelly, Kate Pumpa, David Bruce Pyne, Naroa Etxebarria","doi":"10.1016/j.jshs.2024.101009","DOIUrl":"10.1016/j.jshs.2024.101009","url":null,"abstract":"<p><strong>Background: </strong>Iron facilitates key biological functions underpinning sports performance, and up to 60% of female athletes experience iron deficiency. However, the effects of iron deficiency on sports performance in female athletes is unclear, as are the degree of benefits of iron supplementation (FeSup). This study characterizes the effects of iron deficiency and FeSup on sports performance in high-level female athletes.</p><p><strong>Methods: </strong>Searches of the electronic databases MEDLINE, SPORTDiscus, Web of Science, Scopus, and CINAHL were performed in July 2023. Studies were included that evaluated the effects of iron deficiency or FeSup on sports performance in high-level (maximal oxygen uptake (VO<sub>2max</sub>) > 45 mL/kg/min, or trained > 5 h/week) iron deficient (ID) (serum ferritin (sFer) < 40 µg/L) female athletes. Studies were assessed using a modified Downs and Black Quality Assessment Checklist.</p><p><strong>Results: </strong>A total of 23 studies comprising 669 athletes (age range: 13-47 years) across 16 sports were included in the review. Iron deficiency negatively affects endurance performance by 3%-4%. However, endurance performance improved by 2%-20% when ID athletes were treated with 100 mg/day of elemental iron for up to 56 days via oral supplementation, or bi-daily via parenteral administration over 8-10 days. ID non-anemic athletes with low sFer stores may be predisposed to reduced maximal aerobic capacity. However, maximal aerobic capacity improved by 6%-15% following 16 mg/day-100 mg/day of elemental iron for 36-126 days. Isokinetic strength and anaerobic power performance may be impeded (-23% to +4%) among ID athletes, but the effect of FeSup on anaerobic power varied markedly (-5% to +9%) following 100 mg/day of elemental iron over 42-56 days, or 100 mg of elemental iron bi-daily over 8-10 days. The quality of studies was moderate (77%), ranging from low (57%) to high (100%). Moststudies (n = 18) contained group sizes ≤ 20 athletes, thus limiting the likelihood of detecting significant effects (statistical power > 0.80).</p><p><strong>Conclusion: </strong>High-level ID female athletes experience a negative impact on endurance performance, which can be improved by supplementing with ∼100 mg of elemental iron per day or bi-daily. The decrements in other performance parameters characterizing a range of sports coincide with the severity of iron deficiency.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101009"},"PeriodicalIF":10.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of muscle warm-up on voluntary and evoked force-time parameters: A systematic review and meta-analysis with meta-regression. 肌肉热身对自主和诱发力-时间参数的影响:系统回顾和meta-回归分析。
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2025-01-25 DOI: 10.1016/j.jshs.2025.101024
Cody J Wilson, João Pedro Nunes, Anthony J Blazevich

Background: While muscle contractility increases with muscle temperature, there is no consensus on the best warm-up protocol to use before resistance training or sports exercise due to the range of possible warm-up and testing combinations available. Therefore, the objective of the current study was to determine the effects of different warm-up types (active, exercise-based vs. passive) on muscle function tested using different activation methods (voluntary vs. evoked) and performance test criteria (maximum force vs. rate-dependent contractile properties), with consideration of warm-up task specificity (specific vs. non-specific), temperature measurement method (muscle vs. skin), baseline temperatures, and subject-specific variables (training status and sex).

Methods: A systematic search was conducted in PubMed/MEDLINE, Scopus, Web of Science, Cochrane, Embase, and ProQuest. Random-effects meta-analyses and meta-regressions were used to compute the effect sizes (ES) and 95 % confidence intervals (95 %CIs) to examine the effects of warm-up type, activation method, performance criterion, subject characteristics, and study design on temperature-related performance enhancement.

Results: The search yielded 1272 articles, of which 33 met the inclusion criteria (n = 921). Increasing temperature positively affected both voluntary (3.7 %/°C ± 1.8 %/°C (mean ± SD), ES = 0.28 (95 %CI: 0.14 to 0.41)) and evoked (3.2 %/°C ± 1.5 %/°C (mean ± SD), ES = 0.65 (95 %CI: 0.29 to 1.00)) rate-dependent contractile properties (dynamic, fast-velocity force production, and rate of force development (RFD)) but not maximum force production (voluntary: -0.2 %/°C ± 0.9 %/°C (mean ± SD), ES = 0.08 (95 %CI: -0.05 to 0.22); evoked: -0.1 %/°C ± 0.8 %/°C (mean ± SD), ES = -0.20 (95 %CI: -0.50 to 0.10)). Active warm-up did not induce greater enhancements in rate-dependent contractile properties (p = 0.284), maximum force production (p = 0.723), or overall function (pooled, p = 0.093) than passive warm-up. Meta-regressions did not reveal a significant effect of study design, temperature measurement method, warm-up task specificity, training status, or sex on the effect of increasing temperature (p > 0.05).

Conclusion: Increasing muscle temperature significantly enhances rate-dependent contractile function (RFD and muscle power) but not maximum force in both evoked and voluntary contractions. In contrast to expectation, no effects of warm-up modality (active vs. passive) or temperature measurement method (muscle vs. skin) were detected, although insufficient data prevented robust sub-group analyses.

背景:虽然肌肉收缩能力随着肌肉温度的升高而增加,但由于可能的热身和测试组合的范围,在阻力训练或运动之前使用的最佳热身方案尚未达成共识。因此,本研究的目的是确定不同的热身类型(主动的、基于运动的、被动的)对肌肉功能的影响,使用不同的激活方法(自愿的、诱发的)和性能测试标准(最大力量、速率依赖的收缩特性),考虑热身任务的特异性(特异性的、非特异性的)、温度测量方法(肌肉的、皮肤的)、基线温度、以及特定科目的变量(训练状态和性别)。方法:系统检索PubMed/MEDLINE、Scopus、Web of Science、Cochrane、Embase、ProQuest等数据库。采用随机效应meta分析和meta回归计算效应量(ES)和95%置信区间(95% ci),检验热身类型、激活方式、运动标准、受试者特征和研究设计对温度相关运动能力增强的影响。结果:共检索到1272篇文献,其中33篇符合纳入标准(n = 921)。温度升高对自发性(3.7%±1.8%/°C, ES = 0.28 (95%CI: 0.14, 0.41))和诱发性(3.2%±1.5%/°C, ES = 0.65 (95%CI: 0.29, 1.00))速率相关的收缩特性(动态、快速发力和发力速率(RFD))均有积极影响,但对最大发力(自发性:-0.2%±0.9%/°C, ES = 0.08 (95%CI: -0.05, 0.22)没有积极影响;诱发:-0.1%±0.8% /°C, ES = -0.20(95%置信区间ci: -0.50, 0.10))。与被动热身相比,主动热身在速率相关的收缩性能(p = 0.284)、最大发力(p = 0.723)或整体功能(p = 0.093)方面并没有产生更大的增强。meta回归未显示研究设计、温度测量方法、热身任务特异性、训练状态或性别对温度升高效果的显著影响(p < 0.05)。结论:升高肌肉温度可显著增强速率依赖性收缩功能(RFD和肌力),但不能增强诱发性收缩和自发性收缩的最大收缩力。与预期相反,没有检测到热身方式(主动vs被动)或温度测量方法(肌肉vs皮肤)的影响,尽管数据不足,无法进行稳健的亚组分析。
{"title":"The effect of muscle warm-up on voluntary and evoked force-time parameters: A systematic review and meta-analysis with meta-regression.","authors":"Cody J Wilson, João Pedro Nunes, Anthony J Blazevich","doi":"10.1016/j.jshs.2025.101024","DOIUrl":"10.1016/j.jshs.2025.101024","url":null,"abstract":"<p><strong>Background: </strong>While muscle contractility increases with muscle temperature, there is no consensus on the best warm-up protocol to use before resistance training or sports exercise due to the range of possible warm-up and testing combinations available. Therefore, the objective of the current study was to determine the effects of different warm-up types (active, exercise-based vs. passive) on muscle function tested using different activation methods (voluntary vs. evoked) and performance test criteria (maximum force vs. rate-dependent contractile properties), with consideration of warm-up task specificity (specific vs. non-specific), temperature measurement method (muscle vs. skin), baseline temperatures, and subject-specific variables (training status and sex).</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed/MEDLINE, Scopus, Web of Science, Cochrane, Embase, and ProQuest. Random-effects meta-analyses and meta-regressions were used to compute the effect sizes (ES) and 95 % confidence intervals (95 %CIs) to examine the effects of warm-up type, activation method, performance criterion, subject characteristics, and study design on temperature-related performance enhancement.</p><p><strong>Results: </strong>The search yielded 1272 articles, of which 33 met the inclusion criteria (n = 921). Increasing temperature positively affected both voluntary (3.7 %/°C ± 1.8 %/°C (mean ± SD), ES = 0.28 (95 %CI: 0.14 to 0.41)) and evoked (3.2 %/°C ± 1.5 %/°C (mean ± SD), ES = 0.65 (95 %CI: 0.29 to 1.00)) rate-dependent contractile properties (dynamic, fast-velocity force production, and rate of force development (RFD)) but not maximum force production (voluntary: -0.2 %/°C ± 0.9 %/°C (mean ± SD), ES = 0.08 (95 %CI: -0.05 to 0.22); evoked: -0.1 %/°C ± 0.8 %/°C (mean ± SD), ES = -0.20 (95 %CI: -0.50 to 0.10)). Active warm-up did not induce greater enhancements in rate-dependent contractile properties (p = 0.284), maximum force production (p = 0.723), or overall function (pooled, p = 0.093) than passive warm-up. Meta-regressions did not reveal a significant effect of study design, temperature measurement method, warm-up task specificity, training status, or sex on the effect of increasing temperature (p > 0.05).</p><p><strong>Conclusion: </strong>Increasing muscle temperature significantly enhances rate-dependent contractile function (RFD and muscle power) but not maximum force in both evoked and voluntary contractions. In contrast to expectation, no effects of warm-up modality (active vs. passive) or temperature measurement method (muscle vs. skin) were detected, although insufficient data prevented robust sub-group analyses.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101024"},"PeriodicalIF":10.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prehabilitation during neoadjuvant chemotherapy results in an enhanced immune response in esophageal adenocarcinoma tumors: A randomized controlled trial. 新辅助化疗期间的预适应可增强食管腺癌肿瘤的免疫反应:一项随机对照试验。
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2025-06-09 DOI: 10.1016/j.jshs.2025.101063
Charles J Rayner, David B Bartlett, Sophie K Allen, Tyler Wooldridge, Tadd Seymour, Sunny Sunshine, Julie Hunt, David King, Izhar Bagwan, Javed Sultan, Shaun R Preston, Adam E Frampton, Nicola E Annels, Nima Abbassi-Ghadi
<p><strong>Background: </strong>For patients with locally advanced esophagogastric cancer, the standard of care in the UK is neoadjuvant chemotherapy (NAC) followed by surgery. Prehabilitation exercise training can improve physiological function and fitness. If such improvements translate to increased immune infiltration of tumors, exercise could be prescribed as an immune adjuvant during NAC and potentially improve clinical outcomes. As such, we aimed to determine whether prehabilitation increased tumor infiltrating lymphocytes (TILs).</p><p><strong>Methods: </strong>We assessed 22 patients with locally advanced esophageal cancer on a randomized control trial comparing 16 weeks of low-to-moderate intensity twice weekly supervised and thrice weekly home-based exercise (Prehab: n = 11) to no prehabilitation (Control: n = 11). Our primary outcome was to compare tumor-immune responses between Controls and Prehab. We compared formalin-fixed paraffin-embedded tumors by high-resolution multispectral immunohistochemistry (mIHC) and NanoString spatial transcriptomics. Secondarily, we determined relationships between changes in fitness to the exercise training and tumor-immune measures. Specifically, we assessed percentage changes in peak cardiorespiratory fitness as assessed by peak oxygen uptake (V̇O<sub>2peak</sub>) before NAC (Baseline) and after 8 weeks of NAC (Post-NAC), and changes between Baseline and following 8 weeks of NAC recovery before surgery (Pre-surgery) and correlated changes in fitness with tumor-immune responses. Finally, as an exploratory aim, we assessed clinical outcomes between groups, including survival, therapy tolerance, and tumor regrading.</p><p><strong>Results: </strong>We observed that Prehab had significantly more CD8+ lymphocytes in their tumors (mean difference (diff.) = 1.79, 95% confidence interval (95%CI): 0.76‒2.82, p < 0.001) and their stroma (mean diff. = 1.59, 95%CI: 0.66‒2.52, p < 0.001) than the Controls. When normalized to total numbers of TILs, Prehab had higher levels of CD56+ natural killer (NK) cells (median diff. = 0.87, 95%CI: 0.25‒2.18), p = 0.0274), consisting primarily of CD56<sup>dim</sup> NK cells (median diff. = 0.48, 95%CI: 0.03‒2.53), p = 0.0464). Evaluation of the presence and localization of tumor-associated tertiary lymphoid structures (TLS) in the esophageal tumors revealed that most TLS were in the peritumoral regions. Prehab had a higher TLS cell density (cells/mm<sup>2</sup>; median diff. = 18,959, 95%CI: 13,518‒22,635), p < 0.001) and more clearly defined germinal centers indicative of mature TLS visually. We observed that Prehab maintained their V̇O<sub>2peak</sub> during NAC while the Controls' V̇O<sub>2peak</sub> reduced by 9.0% ± 10.2% (mean ± SD) (Post-NAC: p = 0.018). Pre-surgery, Prehab V̇O<sub>2peak</sub> was a clinically meaningful 3.27 ± 1.31 mL/kg/min higher than Controls (p = 0.022). Between Baseline and Post-NAC, where the Prehab maintained V̇O<sub>2peak</sub> better than Contr
背景:对于局部晚期食管胃癌患者,英国的标准治疗是新辅助化疗(NAC)后手术。康复前运动训练能提高生理机能和体能。如果这种改善转化为肿瘤免疫浸润的增加,运动可以作为NAC期间的免疫佐剂,并可能改善临床结果。因此,我们的目的是确定预适应是否会增加肿瘤浸润淋巴细胞(til)。方法:我们在一项随机对照试验中评估了22例局部晚期食管癌患者,比较了16周的低至中等强度每周两次有监督和每周三次的家庭运动(Prehab: n = 11)和无预康复(control: n = 11)。我们的主要结局是比较对照组和Prehab组的肿瘤免疫反应。我们通过高分辨率多光谱免疫组织化学(mIHC)和纳米串空间转录组学比较了福尔马林固定石蜡包埋肿瘤。其次,我们确定了运动训练的适应性变化与肿瘤免疫措施之间的关系。具体而言,我们评估了NAC前(基线)和NAC后8周(后)的峰值摄氧量(V氧o2峰值),基线和NAC恢复后8周(术前)之间的变化以及适应度与肿瘤免疫反应的相关变化。最后,作为一个探索性目的,我们评估了两组之间的临床结果,包括生存、治疗耐受性和肿瘤分级。结果:我们观察到Prehab组肿瘤中CD8+淋巴细胞(平均差异(diff.) = 1.79,95%可信区间(95% ci): 0.76-2.82, p < 0.001)和间质(平均差异(diff.) = 1.59,95% ci: 0.66-2.52, p < 0.001)明显高于对照组。当归一化到til总数时,Prehab具有更高水平的CD56+ NK细胞(中位数diff. = 0.87,95%CI: 0.25-2.18), p = 0.0274),主要由CD56暗淡NK细胞组成(中位数diff. = 0.48,95%CI: 0.03-2.53), p = 0.0464)。对食管癌肿瘤相关三级淋巴结构(TLS)的存在和定位的评估显示,大多数TLS位于肿瘤周围区域。Prehab具有较高的TLS细胞密度(cells/mm2;中位数差异( = 18,959,95%CI: 13,518-22,635), p < 0.001)和更明确定义的生发中心,在视觉上表明成熟的TLS。我们观察到在NAC期间,Prehab组保持了他们的V o 2峰值,而对照组的V o 2峰值下降了9.0%±10.2% (mean±SD) (NAC后:p = 0.018)。术前Prehab V / o2峰值较对照组增高3.27±1.31 mL/kg/min (p = 0.022),具有临床意义。基线和Post-NAC之间,Prehab保持V̇O2peak比控制,有显著正关联百分比变化V̇O2peak和CD8 +尖的频率(r = 0.531,p = 0.016),编程death-ligand 1 + (PDL1 +)细胞(r = 0.566,p = 0.009),和granzyme B + (GrzB +)尖(r = 0.592,p = 0.007)。仅在Prehab组中,从基线到术前的V / o峰值变化也观察到类似的关系。我们观察到两组之间在临床结果方面没有差异,如生存、治疗耐受性或肿瘤分级。结论:我们发现NAC期间的运动训练比不运动能提高心肺健康水平,这与TILs的频率增加和TLS的成熟度有关。这些数据表明,NAC期间的锻炼可以增强免疫系统。未来的研究有必要了解其临床后果。
{"title":"Prehabilitation during neoadjuvant chemotherapy results in an enhanced immune response in esophageal adenocarcinoma tumors: A randomized controlled trial.","authors":"Charles J Rayner, David B Bartlett, Sophie K Allen, Tyler Wooldridge, Tadd Seymour, Sunny Sunshine, Julie Hunt, David King, Izhar Bagwan, Javed Sultan, Shaun R Preston, Adam E Frampton, Nicola E Annels, Nima Abbassi-Ghadi","doi":"10.1016/j.jshs.2025.101063","DOIUrl":"10.1016/j.jshs.2025.101063","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;For patients with locally advanced esophagogastric cancer, the standard of care in the UK is neoadjuvant chemotherapy (NAC) followed by surgery. Prehabilitation exercise training can improve physiological function and fitness. If such improvements translate to increased immune infiltration of tumors, exercise could be prescribed as an immune adjuvant during NAC and potentially improve clinical outcomes. As such, we aimed to determine whether prehabilitation increased tumor infiltrating lymphocytes (TILs).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We assessed 22 patients with locally advanced esophageal cancer on a randomized control trial comparing 16 weeks of low-to-moderate intensity twice weekly supervised and thrice weekly home-based exercise (Prehab: n = 11) to no prehabilitation (Control: n = 11). Our primary outcome was to compare tumor-immune responses between Controls and Prehab. We compared formalin-fixed paraffin-embedded tumors by high-resolution multispectral immunohistochemistry (mIHC) and NanoString spatial transcriptomics. Secondarily, we determined relationships between changes in fitness to the exercise training and tumor-immune measures. Specifically, we assessed percentage changes in peak cardiorespiratory fitness as assessed by peak oxygen uptake (V̇O&lt;sub&gt;2peak&lt;/sub&gt;) before NAC (Baseline) and after 8 weeks of NAC (Post-NAC), and changes between Baseline and following 8 weeks of NAC recovery before surgery (Pre-surgery) and correlated changes in fitness with tumor-immune responses. Finally, as an exploratory aim, we assessed clinical outcomes between groups, including survival, therapy tolerance, and tumor regrading.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We observed that Prehab had significantly more CD8+ lymphocytes in their tumors (mean difference (diff.) = 1.79, 95% confidence interval (95%CI): 0.76‒2.82, p &lt; 0.001) and their stroma (mean diff. = 1.59, 95%CI: 0.66‒2.52, p &lt; 0.001) than the Controls. When normalized to total numbers of TILs, Prehab had higher levels of CD56+ natural killer (NK) cells (median diff. = 0.87, 95%CI: 0.25‒2.18), p = 0.0274), consisting primarily of CD56&lt;sup&gt;dim&lt;/sup&gt; NK cells (median diff. = 0.48, 95%CI: 0.03‒2.53), p = 0.0464). Evaluation of the presence and localization of tumor-associated tertiary lymphoid structures (TLS) in the esophageal tumors revealed that most TLS were in the peritumoral regions. Prehab had a higher TLS cell density (cells/mm&lt;sup&gt;2&lt;/sup&gt;; median diff. = 18,959, 95%CI: 13,518‒22,635), p &lt; 0.001) and more clearly defined germinal centers indicative of mature TLS visually. We observed that Prehab maintained their V̇O&lt;sub&gt;2peak&lt;/sub&gt; during NAC while the Controls' V̇O&lt;sub&gt;2peak&lt;/sub&gt; reduced by 9.0% ± 10.2% (mean ± SD) (Post-NAC: p = 0.018). Pre-surgery, Prehab V̇O&lt;sub&gt;2peak&lt;/sub&gt; was a clinically meaningful 3.27 ± 1.31 mL/kg/min higher than Controls (p = 0.022). Between Baseline and Post-NAC, where the Prehab maintained V̇O&lt;sub&gt;2peak&lt;/sub&gt; better than Contr","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101063"},"PeriodicalIF":10.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes. 加速计测量的 2 型糖尿病和糖尿病前期患者的体力活动、久坐行为以及大血管和微血管事件的发生率。
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2024-08-29 DOI: 10.1016/j.jshs.2024.100973
Yannis Yan Liang, Yu He, Piao Huang, Hongliang Feng, Haiteng Li, Sizhi Ai, Jing Du, Huachen Xue, Yaping Liu, Jun Zhang, Lu Qi, Jihui Zhang

Background: Physical activity (PA) is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus (T2DM) and prediabetes, but existing evidence relies mainly on self-reported measurements. We aimed to describe the intensity-specific dose-response associations of PA and sedentary behavior (SB) with macrovascular and microvascular events among individuals with T2DM and prediabetes.

Methods: This study included 11,474 individuals with T2DM and prediabetes from the UK Biobank. PA, including total PA, moderate-to-vigorous intensity PA (MVPA), light-intensity PA (LPA), and SB, were measured by accelerometers over 7 days. MVPA was categorized according to the American Diabetes Association guideline-recommended level (at least 150 min/week), and total PA, LPA, and SB were grouped by tertiles. The outcomes were incidences of macrovascular events, microvascular events, heart failure (HF), and their combination (composite events). The events were ascertained using the International Classification of Diseases-10 (ICD-10) codes on the hospital or death records.

Results: During a median follow-up of 6.8 years, 1680 cases were documented, including 969 macrovascular events, 839 microvascular events, and 284 incidents of HF. Accelerometer-measured PA, irrespective of intensity, was inversely associated with the risk of composite events and each outcome in the dose-response patterns. Regarding categorized PA, engagement in total PA (high vs. low) was associated with decreased risk of macrovascular events (hazard ratio (HR) = 0.80; 95% confidence interval (95%CI): 0.67-0.95), microvascular events (HR = 0.76; 95%CI: 0.63-0.93), and HF (HR = 0.46; 95%CI: 0.32-0.66). Adherence to MVPA, but not LPA, above the guideline-recommended level (at least 150 min/week) was associated with reduced risk of macrovascular events (HR = 0.80; 95%CI: 0.68-0.95), microvascular events (HR = 0.76; 95%CI: 0.63-0.92), and HF (HR = 0.65; 95%CI: 0.46-0.92). The minimum dose of MVPA for lowering the risk of composite events was approximately 59.0 min/week. More time spent in SB was associated with an increased risk of composite events (high vs. low, HR = 1.17; 95%CI: 1.02-1.35) and HF (high vs. low, HR = 1.54; 95%CI: 1.09-2.20). Replacement of 30 min of SB (HR = 0.73; 95%CI: 0.65-0.81) and LPA (HR = 0.74; 95%CI: 0.66-0.83) with MVPA dramatically reduced the risk of composite events.

Conclusion: Adherence to a higher amount of accelerometer-measured PA, especially MVPA at least 59 min/week, is associated with reduced risks of macrovascular and microvascular events among individuals with T2DM and prediabetes. Replacement of SB and LPA with MVPA helped lower the risk of diabetic vascular events.

背景:体力活动(PA)被认为有利于降低2型糖尿病(T2DM)和糖尿病前期患者的心血管风险,但现有证据主要依赖于自我报告的测量结果。我们的目的是描述T2DM和糖尿病前期患者的运动强度和久坐行为(SB)与大血管和微血管事件的剂量-反应关系:这项研究纳入了英国生物库中的 11,474 名 T2DM 和糖尿病前期患者。PA包括总PA、中等至剧烈强度PA(MVPA)、轻度强度PA(LPA)和SB,由加速度计进行7天测量。MVPA根据美国糖尿病协会指南推荐的水平(至少150分钟/周)进行分类,总PA、LPA和SB则按三级分组。研究结果为大血管事件、微血管事件、心力衰竭(HF)以及它们的组合(复合事件)的发生率。这些事件是根据医院或死亡记录上的 ICD-10 编码确定的:中位随访时间为 6.8 年,共记录了 1680 个病例,其中包括 969 个大血管事件、839 个微血管事件和 284 个心力衰竭事件。用加速度计测量的活动量,无论强度如何,都与综合事件风险和剂量-反应模式中的每种结果成反比。在分类的PA方面,参与总PA(高与低)与大血管事件(危险比(HR)=0.80;95%置信区间(95%CI):0.67-0.95)、微血管事件(HR=0.76;95%CI:0.63-0.93)和HF(HR=0.46;95%CI:0.32-0.66)风险的降低相关。坚持超过指南推荐水平(至少 150 分钟/周)的 MVPA(而非 LPA)与大血管事件(HR = 0.80;95%CI:0.68-0.95)、微血管事件(HR = 0.76;95%CI:0.63-0.92)和 HF(HR = 0.65;95%CI:0.46-0.92)风险的降低有关。降低综合事件风险的最低 MVPA 剂量约为 59.0 分钟/周。SB时间越长,发生综合事件(高与低,HR = 1.17;95%CI:1.02-1.35)和HF(高与低,HR = 1.54;95%CI:1.09-2.20)的风险越高。用 MVPA 取代 30 分钟的 SB(HR = 0.73;95%CI:0.65-0.81)和 LPA(HR = 0.74;95%CI:0.66-0.83)可显著降低复合事件的风险:结论:T2DM 和糖尿病前期患者坚持较高的加速度计测量的 PA,尤其是 MVPA 至少 59 分钟/周,与降低大血管和微血管事件风险有关。用 MVPA 取代 SB 和 LPA 有助于降低糖尿病血管事件的风险。
{"title":"Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes.","authors":"Yannis Yan Liang, Yu He, Piao Huang, Hongliang Feng, Haiteng Li, Sizhi Ai, Jing Du, Huachen Xue, Yaping Liu, Jun Zhang, Lu Qi, Jihui Zhang","doi":"10.1016/j.jshs.2024.100973","DOIUrl":"10.1016/j.jshs.2024.100973","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus (T2DM) and prediabetes, but existing evidence relies mainly on self-reported measurements. We aimed to describe the intensity-specific dose-response associations of PA and sedentary behavior (SB) with macrovascular and microvascular events among individuals with T2DM and prediabetes.</p><p><strong>Methods: </strong>This study included 11,474 individuals with T2DM and prediabetes from the UK Biobank. PA, including total PA, moderate-to-vigorous intensity PA (MVPA), light-intensity PA (LPA), and SB, were measured by accelerometers over 7 days. MVPA was categorized according to the American Diabetes Association guideline-recommended level (at least 150 min/week), and total PA, LPA, and SB were grouped by tertiles. The outcomes were incidences of macrovascular events, microvascular events, heart failure (HF), and their combination (composite events). The events were ascertained using the International Classification of Diseases-10 (ICD-10) codes on the hospital or death records.</p><p><strong>Results: </strong>During a median follow-up of 6.8 years, 1680 cases were documented, including 969 macrovascular events, 839 microvascular events, and 284 incidents of HF. Accelerometer-measured PA, irrespective of intensity, was inversely associated with the risk of composite events and each outcome in the dose-response patterns. Regarding categorized PA, engagement in total PA (high vs. low) was associated with decreased risk of macrovascular events (hazard ratio (HR) = 0.80; 95% confidence interval (95%CI): 0.67-0.95), microvascular events (HR = 0.76; 95%CI: 0.63-0.93), and HF (HR = 0.46; 95%CI: 0.32-0.66). Adherence to MVPA, but not LPA, above the guideline-recommended level (at least 150 min/week) was associated with reduced risk of macrovascular events (HR = 0.80; 95%CI: 0.68-0.95), microvascular events (HR = 0.76; 95%CI: 0.63-0.92), and HF (HR = 0.65; 95%CI: 0.46-0.92). The minimum dose of MVPA for lowering the risk of composite events was approximately 59.0 min/week. More time spent in SB was associated with an increased risk of composite events (high vs. low, HR = 1.17; 95%CI: 1.02-1.35) and HF (high vs. low, HR = 1.54; 95%CI: 1.09-2.20). Replacement of 30 min of SB (HR = 0.73; 95%CI: 0.65-0.81) and LPA (HR = 0.74; 95%CI: 0.66-0.83) with MVPA dramatically reduced the risk of composite events.</p><p><strong>Conclusion: </strong>Adherence to a higher amount of accelerometer-measured PA, especially MVPA at least 59 min/week, is associated with reduced risks of macrovascular and microvascular events among individuals with T2DM and prediabetes. Replacement of SB and LPA with MVPA helped lower the risk of diabetic vascular events.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"100973"},"PeriodicalIF":10.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Development of an accelerometer age- and sex-specific approach based on population-standardized values for physical activity surveillance: A proof of concept". 关于 "基于人口标准化值开发针对不同年龄和性别的加速度计方法,用于体力活动监测:概念验证 "发表评论。
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.jshs.2024.101004
Alex V Rowlands, Richard P Troiano
{"title":"Comment on \"Development of an accelerometer age- and sex-specific approach based on population-standardized values for physical activity surveillance: A proof of concept\".","authors":"Alex V Rowlands, Richard P Troiano","doi":"10.1016/j.jshs.2024.101004","DOIUrl":"10.1016/j.jshs.2024.101004","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101004"},"PeriodicalIF":10.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between physical activity and incident atherosclerotic cardiovascular disease is modified by predicted cardiovascular risk: The China-PAR project. 体育活动与动脉粥样硬化性心血管疾病之间的关系被预测心血管风险修正:China-PAR项目
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2025-02-22 DOI: 10.1016/j.jshs.2025.101031
Tao Zhou, Chenxi Yuan, Chong Shen, Shufeng Chen, Jianxin Li, Keyong Huang, Xueli Yang, Xiaoqing Liu, Jie Cao, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Dongfeng Gu, Xiangfeng Lu, Fangchao Liu

Background: It remains unclear whether the cardiovascular benefits of physical activity (PA) vary across populations with different predicted atherosclerotic cardiovascular disease (ASCVD) risks. This study aimed to determine the modification of predicted cardiovascular risk on the association between PA and ASCVD incidence.

Methods: A total of 94,734 participants without ASCVD in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project were included, with a median follow-up of 6.0 years. PA volume (metabolic equivalent of task (MET)-h/day) and intensity (%, percentage of moderate-to-vigorous PA (MVPA)) were assessed by questionnaires. Based on the ASCVD 10-year and lifetime risk prediction scores, participants were classified into low-to-medium-risk and high-risk groups. Hazard ratios (HRs) and 95% confidence intervals (95%CIs) for ASCVD were calculated using Cox proportional hazards models.

Results: During 679,438 person-years of follow-up, 3470 ASCVD events occurred. Higher PA volume was associated with lower ASCVD incidence, which was more pronounced among high-predicted-risk individuals than their low-to-medium-risk counterparts, with HRs (95%CIs) of 0.58 (0.50-0.67) and 0.62 (0.53-0.71) for the highest vs. lowest quartiles of PA volume, respectively. Additionally, analyses for PA intensity showed similar results. Compared with inactive individuals, there was a 32% (95%CI: 25%-38%) and 23% (95%CI: 13%-32%) risk reduction in high- and low-to-medium-risk groups, respectively, when over half of the PA volume was from MVPA. Furthermore, the additive interactions between PA and predicted risk indicated a further risk reduction by increasing PA, especially MVPA, in high-risk individuals.

Conclusion: Engaging in more PA, especially MVPA, reduced the risk of ASCVD incidence, with greater benefits among high-risk individuals. These findings emphasize the imperative for personalized PA recommendations tailored to distinct risk populations-in particular, reinforcing PA guidance for high-risk individuals.

背景:目前尚不清楚体育活动(PA)的心血管益处是否在不同预测动脉粥样硬化性心血管疾病(ASCVD)风险的人群中有所不同。本研究旨在确定预测心血管风险对PA和ASCVD发病率之间关系的影响。方法:中国动脉粥样硬化性心血管疾病风险预测(China- par)项目共纳入94,734名无ASCVD的参与者,中位随访时间为6.0年。通过问卷调查评估PA体积(任务代谢当量(MET)-h/day)和强度(%,中高强度PA (MVPA)百分比)。根据ASCVD 10年和终生风险预测评分,将参与者分为低至中危组和高危组。采用Cox比例风险模型计算ASCVD的风险比(hr)和95%置信区间(95% ci)。结果:在679,438人年的随访期间,发生了3470例ASCVD事件。较高的PA容积与较低的ASCVD发病率相关,这在高预测风险个体中比中低风险个体更为明显,PA容积最高和最低四分位数的hr (95% ci)分别为0.58(0.50-0.67)和0.62(0.53-0.71)。此外,对PA强度的分析也显示了类似的结果。与不运动的个体相比,当超过一半的PA体积来自MVPA时,高风险组和中低风险组的风险分别降低了32% (95%CI: 25%-38%)和23% (95%CI: 13%-32%)。此外,PA和预测风险之间的相互作用表明,在高危人群中,增加PA,特别是MVPA,可以进一步降低风险。结论:更多的PA,尤其是MVPA,可以降低ASCVD的发生风险,在高危人群中获益更大。这些发现强调了针对不同风险人群量身定制个性化PA建议的必要性,特别是加强对高风险个体的PA指导。
{"title":"Association between physical activity and incident atherosclerotic cardiovascular disease is modified by predicted cardiovascular risk: The China-PAR project.","authors":"Tao Zhou, Chenxi Yuan, Chong Shen, Shufeng Chen, Jianxin Li, Keyong Huang, Xueli Yang, Xiaoqing Liu, Jie Cao, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Dongfeng Gu, Xiangfeng Lu, Fangchao Liu","doi":"10.1016/j.jshs.2025.101031","DOIUrl":"10.1016/j.jshs.2025.101031","url":null,"abstract":"<p><strong>Background: </strong>It remains unclear whether the cardiovascular benefits of physical activity (PA) vary across populations with different predicted atherosclerotic cardiovascular disease (ASCVD) risks. This study aimed to determine the modification of predicted cardiovascular risk on the association between PA and ASCVD incidence.</p><p><strong>Methods: </strong>A total of 94,734 participants without ASCVD in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project were included, with a median follow-up of 6.0 years. PA volume (metabolic equivalent of task (MET)-h/day) and intensity (%, percentage of moderate-to-vigorous PA (MVPA)) were assessed by questionnaires. Based on the ASCVD 10-year and lifetime risk prediction scores, participants were classified into low-to-medium-risk and high-risk groups. Hazard ratios (HRs) and 95% confidence intervals (95%CIs) for ASCVD were calculated using Cox proportional hazards models.</p><p><strong>Results: </strong>During 679,438 person-years of follow-up, 3470 ASCVD events occurred. Higher PA volume was associated with lower ASCVD incidence, which was more pronounced among high-predicted-risk individuals than their low-to-medium-risk counterparts, with HRs (95%CIs) of 0.58 (0.50-0.67) and 0.62 (0.53-0.71) for the highest vs. lowest quartiles of PA volume, respectively. Additionally, analyses for PA intensity showed similar results. Compared with inactive individuals, there was a 32% (95%CI: 25%-38%) and 23% (95%CI: 13%-32%) risk reduction in high- and low-to-medium-risk groups, respectively, when over half of the PA volume was from MVPA. Furthermore, the additive interactions between PA and predicted risk indicated a further risk reduction by increasing PA, especially MVPA, in high-risk individuals.</p><p><strong>Conclusion: </strong>Engaging in more PA, especially MVPA, reduced the risk of ASCVD incidence, with greater benefits among high-risk individuals. These findings emphasize the imperative for personalized PA recommendations tailored to distinct risk populations-in particular, reinforcing PA guidance for high-risk individuals.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101031"},"PeriodicalIF":10.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health-related physical fitness in children and adolescents and the United Nations Sustainable Development Goals: Signals of convergence 儿童和青少年与健康有关的身体健康与联合国可持续发展目标:趋同的信号
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-11-27 DOI: 10.1016/j.jshs.2025.101105
Diego Augusto Santos Silva, Mark S. Tremblay
{"title":"Health-related physical fitness in children and adolescents and the United Nations Sustainable Development Goals: Signals of convergence","authors":"Diego Augusto Santos Silva, Mark S. Tremblay","doi":"10.1016/j.jshs.2025.101105","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101105","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"27 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China 动物运动干预研究在慢性病防治中的基础研究专家共识声明:中国生物物理学会运动科学分会与中国遗传学会代谢与遗传学分会联合立场文件
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-11-22 DOI: 10.1016/j.jshs.2025.101103
Yihua Bei, Dan Zhong, Junmei Lu, Yan Qiu, T. Scott Bowen, Ning Chen, Yaoshan Dun, Feng Gao, Yu Huang, Guoping Li, Jia Li, Jin Li, Fangchao Liu, Weina Liu, Xinran Ma, Anthony Rosenzweig, Michail Spanos, Zhenjun Tian, Peng Yin, Ru Wang, Yao Wang, Danyan Xu, Lingyan Xu, Li Zhang, Jihui Zhang, Xing Zhang, Qiulian Zhou, Yuandong Qiao, Ming Xu, Junjie Xiao
{"title":"Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China","authors":"Yihua Bei, Dan Zhong, Junmei Lu, Yan Qiu, T. Scott Bowen, Ning Chen, Yaoshan Dun, Feng Gao, Yu Huang, Guoping Li, Jia Li, Jin Li, Fangchao Liu, Weina Liu, Xinran Ma, Anthony Rosenzweig, Michail Spanos, Zhenjun Tian, Peng Yin, Ru Wang, Yao Wang, Danyan Xu, Lingyan Xu, Li Zhang, Jihui Zhang, Xing Zhang, Qiulian Zhou, Yuandong Qiao, Ming Xu, Junjie Xiao","doi":"10.1016/j.jshs.2025.101103","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101103","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"9 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions 负荷引起的人类骨骼肌肥大:机制、神话和误解
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-11-22 DOI: 10.1016/j.jshs.2025.101104
Derrick W. Van Every, Matthew J. Lees, Brandan Wilson, Jeff Nippard, Stuart M. Phillips
{"title":"Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions","authors":"Derrick W. Van Every, Matthew J. Lees, Brandan Wilson, Jeff Nippard, Stuart M. Phillips","doi":"10.1016/j.jshs.2025.101104","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101104","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"188 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of strength training lifetime exposure with functional outcomes and mobility over four years: Data from the Osteoarthritis Initiative. 力量训练终生暴露与4年以上功能结果和活动能力的关系:来自骨关节炎倡议的数据。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-11-14 DOI: 10.1016/j.jshs.2025.101102
Daniel Kiehl,Zane Thompson,Alisa J Johnson,Kimberly T Sibille,Kevin R Vincent,Heather K Vincent
BACKGROUNDThis study compared knee osteoarthritis (OA) outcomes specific to pain, physical function, and quality of life in later life based on strength training (ST) participation over a lifetime.METHODSParticipants from the Osteoarthritis Initiative (n = 3192) were grouped by ST engagement during ages 12-18 years, 19-34 years, 35-49 years, and 50+ years. Participants were categorized as: No ST (no ST at any point; 61.7 ± 9.0 years (mean ± SD)), Some ST (engaged in ST during 1-3 life stages; 58.9 ± 8.7 years), and Lifelong ST (consistently engaged in ST across all life stages; 55.6 ± 8.1 years). Measures were collected at baseline and Year 4: Western Ontario and McMaster Universities Osteoarthritis Index scores (WOMAC; pain, daily activities), Knee Injury and Osteoarthritis Outcome Score (KOOS; sports, recreation), Physical Activity Score for the Elderly (PASE), Short Form-12 Physical Component Score (SF-12 PCS), mobility disability, chair rise time, and walking speed (20-m and 400-m).RESULTSAt Year 4, the Lifelong ST group reported better WOMAC activity scores in the right knee along with better WOMAC pain, KOOS sports/recreation, and PASE scores compared to other groups (p < 0.05). The Lifelong ST group had the lowest incidence of mobility disability of all groups (0.8% vs. 2.3%-4.1%; p = 0.015) and maintained the fastest walking speeds in Year 4.CONCLUSIONFor those with knee OA, ST throughout life may help preserve function and mobility, allowing for greater physical activity engagement while keeping pain levels relatively lower.
本研究比较了一生中力量训练(ST)参与程度对疼痛、身体功能和晚年生活质量的膝骨关节炎(OA)结果的影响。方法来自骨关节炎倡议组织(n = 3192)的参与者按ST参与年龄分为12-18岁、19-34岁、35-49岁和50岁以上。参与者分为:无ST(任何时间点无ST; 61.7±9.0年(mean±SD)),部分ST(在1-3个生命阶段从事ST; 58.9±8.7年)和终身ST(在所有生命阶段持续从事ST; 55.6±8.1年)。在基线和四年级收集测量数据:西安大略和麦克马斯特大学骨关节炎指数评分(WOMAC;疼痛,日常活动),膝关节损伤和骨关节炎结局评分(oos;运动,娱乐),老年人身体活动评分(PASE), Short Form-12身体成分评分(SF-12 PCS),行动障碍,椅子起身时间和步行速度(20米和400米)。结果在第4年,与其他组相比,终身ST组报告了更好的右膝WOMAC活动评分,以及更好的WOMAC疼痛,oos运动/娱乐和PASE评分(p < 0.05)。终身ST组的行动障碍发生率最低(0.8% vs. 2.3%-4.1%; p = 0.015),并在第4年保持最快的步行速度。结论:对于膝关节OA患者,终生ST治疗可能有助于保持功能和活动能力,允许更多的身体活动,同时保持相对较低的疼痛水平。
{"title":"Relationship of strength training lifetime exposure with functional outcomes and mobility over four years: Data from the Osteoarthritis Initiative.","authors":"Daniel Kiehl,Zane Thompson,Alisa J Johnson,Kimberly T Sibille,Kevin R Vincent,Heather K Vincent","doi":"10.1016/j.jshs.2025.101102","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101102","url":null,"abstract":"BACKGROUNDThis study compared knee osteoarthritis (OA) outcomes specific to pain, physical function, and quality of life in later life based on strength training (ST) participation over a lifetime.METHODSParticipants from the Osteoarthritis Initiative (n = 3192) were grouped by ST engagement during ages 12-18 years, 19-34 years, 35-49 years, and 50+ years. Participants were categorized as: No ST (no ST at any point; 61.7 ± 9.0 years (mean ± SD)), Some ST (engaged in ST during 1-3 life stages; 58.9 ± 8.7 years), and Lifelong ST (consistently engaged in ST across all life stages; 55.6 ± 8.1 years). Measures were collected at baseline and Year 4: Western Ontario and McMaster Universities Osteoarthritis Index scores (WOMAC; pain, daily activities), Knee Injury and Osteoarthritis Outcome Score (KOOS; sports, recreation), Physical Activity Score for the Elderly (PASE), Short Form-12 Physical Component Score (SF-12 PCS), mobility disability, chair rise time, and walking speed (20-m and 400-m).RESULTSAt Year 4, the Lifelong ST group reported better WOMAC activity scores in the right knee along with better WOMAC pain, KOOS sports/recreation, and PASE scores compared to other groups (p < 0.05). The Lifelong ST group had the lowest incidence of mobility disability of all groups (0.8% vs. 2.3%-4.1%; p = 0.015) and maintained the fastest walking speeds in Year 4.CONCLUSIONFor those with knee OA, ST throughout life may help preserve function and mobility, allowing for greater physical activity engagement while keeping pain levels relatively lower.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"38 1","pages":"101102"},"PeriodicalIF":11.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Sport and Health Science
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1