Integrated solid waste management (ISWM) based on waste valorization represents a shift toward more sustainable and resource-efficient practices. This study examined the effect of source separation programs, two bins (wet-dry (WD) and recyclable-nonrecyclable (R-nR)) and three bins, on biochemical, thermochemical, and hybrid ISWM strategies. A comparative techno-economic and environmental assessment was conducted to evaluate the proposed strategies in countries with various economic standards: high-, upper-middle-, lower-middle-, and low-income. The incineration-based strategies achieved the highest energy recovery, ranging from 430 to 708 kWh per ton of collected waste. On the other hand, the WD-AD and 3B-INC strategies had the lowest (37–81 kg CO2-eq per ton) and highest (140–208 kg CO2-eq per ton) carbon footprint, respectively, across all income levels. Moreover, the two- and three-bin hybrid strategies were the most profitable for all income levels. Overall, the WD-hybrid strategy was the optimum scenario for high-income countries, whereas the biochemical scenarios were the most eco-efficient for middle- and low-income countries. Regional validation was performed using country-specific inputs, confirming the applicability of the modeled outcomes across diverse economic conditions. The findings underscore the importance of tailoring ISWM strategies to various income levels, among other factors, providing valuable insights into sustainable and eco-efficient waste management practices worldwide.
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