Firework oxidizer powders are inorganic compounds that supply active oxygen within pyrotechnic systems. Due to their fine particle size and tendency to leak during handling, accurately simulating their flow behavior is essential for optimizing powder-filling equipment. However, limited research exists on their discrete element method (DEM) parameters, and many key contact properties remain undocumented. This study systematically calibrated six critical DEM contact parameters for firework oxidizer powders-particle density, elastic modulus, Poisson’s ratio, static friction coefficient, rolling friction coefficient, and shear modulus-using a combination of experimental measurements and numerical simulations. The Hertz-Mindlin contact model was adopted, and a Plackett–Burman design was used to identify the most influential parameters affecting the static angle of repose. Results showed that the static friction coefficient, rolling friction coefficient, and shear modulus had the most significant effects. Their optimal ranges were further refined via steepest ascent testing. A Box-Behnken design was employed to develop a regression model for the angle of repose, yielding final calibrated values of 0.288, 0.035, and 65.076 MPa for the three dominant parameters, respectively. These parameters were then applied in DEM simulations of powder flow involving a T-shaped scraper, which pushes the powder toward the dosing holes, allowing it to fall under gravity. Physical filling tests demonstrated that powder leakage was effectively controlled when the scraper speed did not exceed 0.3 m/s. This study provides valuable insights for equipment optimization and offers a reliable reference for DEM-based modeling and design of firework oxidizer powder handling systems.