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The Relationship between Knowledge, Attitude, and Behavior of Fiber Food Consumption with Defection Pattern 纤维食品消费知识、态度和行为与缺陷模式的关系
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-08-03 DOI: 10.9734/ajmah/2023/v21i10881
M. Djojosaputro, N. N. Prihantini
Nowadays, most people like to choose their food from good taste varieties without considering the nutrition. Generally, The average fiber consumption in Indonesia is 10,5 grams/day. This value is not quite enough for the requirement of fiber. An inadequacy of fiber can cause some diseases, and one of them is defecation disorders. This study examines the correlation between knowledge, attitude, and behavior of consuming fibrous food with defecation. This study utilizes Cross Sectional Method. Take an experiment by Consecutive sampling in a total population of 273 respondents and a sample is as many as 162 respondents. The study subjects are students of the Universitas Kristen Indonesia 2018 Medical Faculty. Data preparation will use IBM SPSS Statistic 22, and the result of the research will be presented analytically. The knowledge of students is not enough for fibrous food. Most have a bad attitude toward fibrous food and still rarely consume it. A Chi-Square test shows no correlation between knowledge of fibrous food and defecation pattern, significant frequency of defecation (p =0,071), and stool consistency (p= 0,746). The correlations between the attitude of fibrous food with defecation patterns are frequency of defecation (p=0.012) and stool consistency (p=0.038). The correlations between behaviors of fibrous food with defecation patterns are frequency of defecation (p=0,012) and stool consistency (p = 0,038).
如今,大多数人喜欢从口味好的品种中选择食物,而不考虑营养。一般来说,印度尼西亚的平均纤维消费量为10.5克/天。这个值还不能满足纤维的要求。纤维不足会导致一些疾病,其中之一就是排便障碍。本研究探讨食用纤维性食物的知识、态度和行为与排便的关系。本研究采用横截面法。采用连续抽样的方法,在273名被调查者中进行实验,样本数量多达162人。研究对象为印度尼西亚克里斯汀大学2018医学院的学生。数据准备将使用IBM SPSS Statistic 22,研究结果将以分析的方式呈现。学生对纤维性食物的知识是不够的。大多数人对纤维食物态度不好,仍然很少食用。卡方检验显示,对纤维食物的了解与排便方式、排便频率(p= 0,071)和大便一致性(p= 0,746)之间没有相关性。对纤维性食物的态度与排便频率(p=0.012)和大便稠度(p=0.038)相关。纤维食物的行为与排便模式之间的相关性是排便频率(p= 0.012)和粪便一致性(p= 0.038)。
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引用次数: 0
Depression and Quality of Life among Urban Elderly in Dhaka City during the Covid-19 Pandemic 2019冠状病毒病大流行期间达卡城市老年人抑郁与生活质量
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-08-01 DOI: 10.9734/ajmah/2023/v21i10880
Tarim Mahmood, Tasnim Mahmud, Nabila Nusrat Tripty
Objective: This study was conducted with the aim to determine whether there was any association between depression and quality of life among the urban elderly during the COVID-19 pandemic. Methods: This study was conducted across some urban areas of Dhaka city namely Gulshan, Niketan and Mohakhali areas. 91 respondents aged 60 years and above residing in urban areas were interviewed once at one point in time. All the information was to be collected within the time frame. Hence the most appropriate study design in this case would be cross-sectional study design. The duration for the thesis work was 1 year, from 1st January to 31st December 2020. Method of sampling was convenient method of sampling. Data were collected by face-to-face interview and telephone interview. Results: In case of clinical characteristics, elderly people aged 60 years and above participated. Mean age was 66.42 (SD± 5.106) years. Minimum and maximum age was respectively 60 years and 80 years. Among the 91 respondents, 48 (52.7%) were males and 43 (47.3%) were females. It is found that, 64 (70.3%) were married, 1 (1.1%) was unmarried, 24 (26.4%) were widowed, 2 (2.2%) were divorced. Of all the respondents, 34.1% were graduates and 24.2% were post graduates. Majority of respondents (84.6%) were the followers of Islam, followed by (11%) Hindus. Here, among the 91 respondents, some of them had only one disease, whereas some of them had more than one disease. To explain, 56 (31.8%) had Hypertension, 55 (31.3%) people had Diabetes Mellitus, 32 (18.2%) had cardiac problems, 13 (7.4%) suffered from stroke, 11 (6.3%) had chronic lung disease, 7 (4.0%) suffered from chronic kidney disease, 1 (0.6%) had cancer, and 1 (0.6%) had Alzheimer’s disease. In case of association between depression and psychological domain of quality of life, the highest mean score was found within those who had no depression (M=63.93), followed by mild depression (M=48.95), then moderate depression (M=40.71) and lastly severe depression (M=33.80). To see the impact of level of depression on psychological domain of quality of life, one-way between group ANOVA was conducted. There was statistically significant difference at p<0.05 in QOL for levels of depression: F (3, 87) = 14.019, p=0.00.
目的:本研究旨在确定COVID-19大流行期间城市老年人抑郁与生活质量之间是否存在关联。方法:本研究在达卡的一些城区进行,即Gulshan、Niketan和Mohakhali地区。91名年龄在60岁及以上的城市居民在同一时间点接受了一次访谈。所有的信息都要在规定的时间内收集。因此,在这种情况下,最合适的研究设计将是横断面研究设计。论文工作时间为1年,从2020年1月1日至12月31日。抽样方法为简便的抽样方法。数据收集采用面对面访谈和电话访谈两种方式。结果:根据临床特点,60岁及以上老年人参与。平均年龄66.42 (SD±5.106)岁。最小年龄为60岁,最大年龄为80岁。91名被调查者中,男性48人(52.7%),女性43人(47.3%)。已婚64人(70.3%),未婚1人(1.1%),丧偶24人(26.4%),离婚2人(2.2%)。在所有受访者中,34.1%是大学毕业生,24.2%是研究生。大多数受访者(84.6%)是伊斯兰教徒,其次是印度教徒(11%)。在91名受访者中,有些人只患有一种疾病,而有些人则患有一种以上的疾病。其中56人(31.8%)患有高血压,55人(31.3%)患有糖尿病,32人(18.2%)患有心脏病,13人(7.4%)患有中风,11人(6.3%)患有慢性肺部疾病,7人(4.0%)患有慢性肾脏疾病,1人(0.6%)患有癌症,1人(0.6%)患有阿尔茨海默病。在抑郁与生活质量心理领域的相关性方面,无抑郁者的平均得分最高(M=63.93),其次是轻度抑郁(M=48.95),其次是中度抑郁(M=40.71),最后是重度抑郁(M=33.80)。为观察抑郁程度对生活质量心理领域的影响,采用组间单因素方差分析。各抑郁水平的生活质量差异有统计学意义(p<0.05): F (3,87) = 14.019, p=0.00。
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引用次数: 0
Acute Appendicitis in Pregnancy-Current Management-Review Article 妊娠期急性阑尾炎-现状管理综述
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-24 DOI: 10.9734/ajmah/2023/v21i10879
H. R. Kumar, M. Soma
The management of acute appendicitis in pregnancy is considered controversial, as there is no consensus in terms of diagnosis, investigation, and treatment. Blood investigations like full blood count are of limited value due to the physiological changes that occur in pregnancy. The use of abdominal ultrasound has always been mandatory but magnetic resonance imaging (MRI) is slowly becoming an alternative in the investigation of this condition. Open appendectomy has always been the treatment of choice, but laparoscopic appendectomy is becoming an emerging trend in the management of acute appendicitis in pregnancy. We conducted this narrative review article to evaluate the diagnosis and management of acute appendicitis in pregnancy.
妊娠期急性阑尾炎的处理被认为是有争议的,因为在诊断、调查和治疗方面没有共识。由于怀孕期间发生的生理变化,全血细胞计数等血液检查的价值有限。使用腹部超声一直是强制性的,但磁共振成像(MRI)正在慢慢成为一种替代的调查这种情况。开放阑尾切除术一直是治疗的首选,但腹腔镜阑尾切除术正在成为妊娠急性阑尾炎治疗的新兴趋势。我们对妊娠期急性阑尾炎的诊断和治疗进行了综述。
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引用次数: 0
Exploring the Impacts of Menstrual-Pelvic Pain on School Activity in Rural Secondary School Girls 探讨月经-盆腔疼痛对农村中学女生学习活动的影响
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-22 DOI: 10.9734/ajmah/2023/v21i10877
S. J. Obiekwe, I. P. Ezeugwunne, O. C. Ekwebene, I. Nwaugochi, G. Edeh, Ezenwa Robinson Modum, Christian Chukwunulu Nwoye, Iheohakara Franklin Okechukwu
Aims: Pelvic pain (PP) during menstruation (Dysmenorrhea) is one of the common complaints of women. menstruation has a great negative impact on the quality of life of women both psychologically, behavioural and social well-being. This study is to determine the prevalence of PP during menstruation among secondary school girls. Methodology: A cross-sectional study design conducted among female students at some selected high schools in Anambra state, South-eastern Nigeria in February 2023. A total of 392 study participants were recruited using a convenience sampling technique. A pretested self-administered structured questionnaire was employed. Microsoft excel and SPSS version 26 were used for data entry and analysis respectively. Results: 392 female adolescent high school students aged between 8-19 years old with a mean age at menarche 12.85±1.47 years. 58.9% reported having their menstrual bleeding lasting for 4 days. The prevalence of PP during menstruation was 86.31% with 29.90% with a numerical pain rating of 10. 39.20% reported taking painkillers gotten over the counter, 71.43% reported the pain affecting their activities in school, majority 32.7% don’t socialize with their classmate and 32.0% do not concentrate in classes. While 29.4% do not participate in school outdoor sports activities, 20.3% don’t participate in other school social activities. Statistically significant associations existed between PP during menses and age, age at menarche, bleeding length and bleeding intensity (p<0.05). The school participation of Participants with severe PP during menses were significantly affected (p=0.0001). Conclusion: PP during menstruation was highly prevalent in this study, and highly affected the students’ participation in school activities. The implication of this study highlights the importance of raising awareness, improving access to healthcare services, integrating menstrual health education into the curriculum, and adopting a multidisciplinary approach to support affected adolescents.
目的:月经期间盆腔疼痛(PP)是女性常见的主诉之一。月经对妇女的心理、行为和社会福利的生活质量都有很大的负面影响。本研究旨在了解中学女生月经期间PP的流行情况。方法:采用横断面研究设计,于2023年2月在尼日利亚东南部阿南布拉州的一些选定高中的女学生中进行。采用方便抽样技术共招募了392名研究参与者。采用预先测试的自我管理结构化问卷。数据录入和分析分别使用Microsoft excel和SPSS version 26。结果:高中女生392名,年龄8 ~ 19岁,平均初潮年龄12.85±1.47岁。58.9%的患者月经出血持续4天。月经期PP患病率为86.31%,其中29.90%,疼痛数值评分为10分。39.20%的人服用非处方止痛药,71.43%的人表示疼痛影响了他们在学校的活动,32.7%的人不与同学交往,32.0%的人在课堂上不能集中注意力。29.4%的学生不参加学校的户外体育活动,20.3%的学生不参加学校的其他社会活动。经期PP与年龄、初潮年龄、出血长度、出血强度有统计学意义(p<0.05)。重度PP患者在月经期间的学校参与受到显著影响(p=0.0001)。结论:在本研究中,月经期PP发生率较高,且对学生参与学校活动有较大影响。这项研究的意义突出了提高认识、改善获得保健服务的机会、将月经健康教育纳入课程以及采用多学科方法支持受影响的青少年的重要性。
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引用次数: 0
Adverse Events Following COVID-19 Vaccination in Anambra State, South East Nigeria 尼日利亚东南部阿南布拉州COVID-19疫苗接种后的不良事件
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-22 DOI: 10.9734/ajmah/2023/v21i10878
L. O. Amaka, Eze Chijioke Eze, C. Christian, O. Betrand, I. Sylvia, C. Bede, M. U. Chinyere, D. O. Ifechukwu
The use of safe and effective vaccination is critical to control of pandemics. Vaccines remain the bedrock in management of infectious diseases outbreaks. There has always been hesitancy to vaccination due to the fear of adverse events. It is therefore necessary that post vaccination adverse events be studied for effective enlightenment of the general populace. Objective: We aimed to investigate the adverse reactions following COVID-19 vaccination in Anambra state, South East Nigeria. Methods: Using a cross-sectional study design, 433 subjects aged 18years or older who had received any dose of the four COVID-19 vaccines (Moderna, Astra Zeneca, Pfizer and J&J (Janssen) were selected using a multi-stage sampling technique. The subjects were interviewed about COVID-19 vaccine related adverse reactions using self-administered questionnaire. Descriptive statistics (mean, standard deviation) and analytical statistics were performed and level of significance set at < 0.5 using SPSS V24. Results: Of the 433 subjects finally studied, 62.8% were females and 22.4% were married. About 69% of them had tertiary education.  Those who received the second dose of their respective vaccines were 44.8% while 11.5% had received a booster dose. Approximately half (50.3%) of the COVID-19 vaccines had adverse events. The most common types of adverse events (AEs) were local pain at injection site (62.1%) followed by headache (54.3%) and then fatigue (50.1%). Majority of the adverse events were mild to moderate in severity.  Those who had only local adverse events were 70.2% while 45% had systemic adverse events. Conclusion: In this study, severe adverse events were rare, even after the second dose. Most of the adverse events were mild to moderate in severity and therefore awareness campaign should be created to enlighten the community about the adverse effects of COVID-19 vaccines.
使用安全有效的疫苗接种对于控制大流行至关重要。疫苗仍然是管理传染病暴发的基础。由于担心不良事件,人们一直对接种疫苗犹豫不决。因此,有必要对疫苗接种后的不良事件进行研究,以便对普通民众进行有效的启蒙。目的:了解尼日利亚东南部阿南布拉州COVID-19疫苗接种后的不良反应。方法:采用横断面研究设计,采用多阶段抽样技术,选择433名年龄在18岁及以上、接种过Moderna、Astra Zeneca、Pfizer和J&J (Janssen)四种COVID-19疫苗的受试者。采用自填问卷对受试者进行COVID-19疫苗相关不良反应的访谈。采用SPSS V24进行描述性统计(均值、标准差)和分析性统计,显著性水平设为< 0.5。结果:在最终研究的433名受试者中,女性占62.8%,已婚占22.4%。其中约69%的人受过高等教育。接受第二剂疫苗的占44.8%,而接受加强剂疫苗的占11.5%。大约一半(50.3%)的COVID-19疫苗有不良事件。最常见的不良事件类型是注射部位局部疼痛(62.1%),其次是头痛(54.3%)和疲劳(50.1%)。大多数不良事件的严重程度为轻至中度。仅发生局部不良事件者占70.2%,发生全身不良事件者占45%。结论:在本研究中,即使在第二次给药后,严重的不良事件也很少见。大多数不良事件的严重程度为轻度至中度,因此应开展宣传活动,使社区了解COVID-19疫苗的不良反应。
{"title":"Adverse Events Following COVID-19 Vaccination in Anambra State, South East Nigeria","authors":"L. O. Amaka, Eze Chijioke Eze, C. Christian, O. Betrand, I. Sylvia, C. Bede, M. U. Chinyere, D. O. Ifechukwu","doi":"10.9734/ajmah/2023/v21i10878","DOIUrl":"https://doi.org/10.9734/ajmah/2023/v21i10878","url":null,"abstract":"The use of safe and effective vaccination is critical to control of pandemics. Vaccines remain the bedrock in management of infectious diseases outbreaks. There has always been hesitancy to vaccination due to the fear of adverse events. It is therefore necessary that post vaccination adverse events be studied for effective enlightenment of the general populace. \u0000Objective: We aimed to investigate the adverse reactions following COVID-19 vaccination in Anambra state, South East Nigeria. \u0000Methods: Using a cross-sectional study design, 433 subjects aged 18years or older who had received any dose of the four COVID-19 vaccines (Moderna, Astra Zeneca, Pfizer and J&J (Janssen) were selected using a multi-stage sampling technique. The subjects were interviewed about COVID-19 vaccine related adverse reactions using self-administered questionnaire. Descriptive statistics (mean, standard deviation) and analytical statistics were performed and level of significance set at < 0.5 using SPSS V24. \u0000Results: Of the 433 subjects finally studied, 62.8% were females and 22.4% were married. About 69% of them had tertiary education.  Those who received the second dose of their respective vaccines were 44.8% while 11.5% had received a booster dose. Approximately half (50.3%) of the COVID-19 vaccines had adverse events. The most common types of adverse events (AEs) were local pain at injection site (62.1%) followed by headache (54.3%) and then fatigue (50.1%). Majority of the adverse events were mild to moderate in severity.  Those who had only local adverse events were 70.2% while 45% had systemic adverse events. \u0000Conclusion: In this study, severe adverse events were rare, even after the second dose. Most of the adverse events were mild to moderate in severity and therefore awareness campaign should be created to enlighten the community about the adverse effects of COVID-19 vaccines.","PeriodicalId":49491,"journal":{"name":"Southeast Asian Journal of Tropical Medicine and Public Health","volume":"20 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90460457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence, Pattern and Outcome of Adult Renal Diseases among Admissions in Rivers State University Teaching Hospital: A 4 Year Review 河流州立大学教学医院住院成人肾脏疾病的患病率、模式和预后:4年回顾
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-21 DOI: 10.9734/ajmah/2023/v21i10876
Elageche W. Okachi, Beniboba J. Eleki, Datonye Briggs, Ibinabo Membere
Introduction: Kidney disease is a growing worldwide public health problem and prevalence varies within and between countries. Epidemiological data is therefore imperative for prioritization and adequate resource allocation, especially in settings where no previous data exists. Aim: To determine the prevalence and pattern of renal diseases among adults admitted into the medical wards of Rivers State University Teaching Hospital, Rivers State, Southern Nigeria. Methods: Case notes of all patients admitted into the medical wards were reviewed from January 2019 to December 2022. Data extracted included sociodemographic variables, diagnosis and treatment outcomes of patients with renal disease. Results: Of the 2,725 patients admitted to the medical wards, 386 (14.2%) had renal disease. The mean age of patients was 51.2 ± 16 years. There was a male preponderance of 210 (54.4%) with a M: F = 1.3:1. The most prevalent renal diseases were hypertensive nephropathy 125(32.4%), diabetic nephropathy 91(23.7%), HIV-related renal disease 54(14.0%) and obstructive uropathy 23(6%). Acute kidney injury constituted 37 (9.6%) of renal admissions. Analysis of outcome showed that 254 (65.8%) were discharged home, 17 (4.4%) patients discharged themselves against medical advice, 5 (1.3%) absconded, 2 (0.5%) referred and 108 (28.0%) of them died. The highest mortality (19.4%) occurred among patients with the HIV-related renal disease Conclusion: The prevalence of renal disease is high, with hypertension, diabetes, HIV and obstructive uropathy as its commonest risk factors. Renal diseases still contribute significantly to morbidity and mortality among in-hospital admissions in Rivers State, Southern Nigeria. Preventative measures including health education, advocacy and screening for renal disease are imperative.
肾脏疾病是一个日益严重的全球公共卫生问题,其患病率在国家内部和国家之间有所不同。因此,流行病学数据对于确定优先次序和充分分配资源至关重要,特别是在没有以往数据的情况下。目的:了解尼日利亚南部河流州河流州立大学教学医院住院成人肾脏疾病的患病率和模式。方法:回顾2019年1月至2022年12月住院的所有病区患者的病例记录。提取的数据包括社会人口学变量、肾脏疾病患者的诊断和治疗结果。结果:2725例住院患者中,386例(14.2%)有肾脏疾病。患者平均年龄51.2±16岁。男性优势210例(54.4%),M: F = 1.3:1。最常见的肾脏疾病是高血压肾病125例(32.4%),糖尿病肾病91例(23.7%),hiv相关肾病54例(14.0%),梗阻性尿路病变23例(6%)。急性肾损伤占37例(9.6%)。结果分析:出院254例(65.8%),自行出院17例(4.4%),潜逃5例(1.3%),转诊2例(0.5%),死亡108例(28.0%)。结论:肾脏病患病率高,高血压、糖尿病、HIV和梗阻性尿路病变是其最常见的危险因素。在尼日利亚南部河流州,肾脏疾病仍然是造成住院病人发病率和死亡率的主要原因。包括健康教育、宣传和肾脏疾病筛查在内的预防措施是必不可少的。
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引用次数: 0
Selected haematological markers and C-reactive protein, not AGTR1 SNP, are associated with essential hypertension in Tharaka Nithi County, Kenya 在肯尼亚Tharaka Nithi县,选定的血液学标志物和c反应蛋白与原发性高血压相关,而不是AGTR1 SNP
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-20 DOI: 10.9734/ajmah/2023/v21i10875
A. Mbaabu, Caroline Mangare, Collins Wangulu, Amos Mbugua
Background: Essential Hypertension (EH) accounts for majority of hypertension cases globally. Genetic factors along with haematological and biochemical changes may underlie EH and these have not been well studied in Kenya. A meta-analysis in African populations (excluding East Africa) identified the 1166A>C (rs5186) single nucleotide polymorphism (SNP) in the angiotensin II type 1 receptor gene (AGTR1) that encodes the angiotensin II type 1 receptor as likely to predispose some Africans to hypertension. Aim: The purpose of the study was to determine whether the AGTR1 (rs5186) mutation, C-reactive protein (CRP) and selected haematological biomarkers may be associated with the onset of EH in Tharaka Nithi County, Kenya). Study Design: A case control study design was adopted. Place and Duration of Study: The research was conducted from March to July 2022 at Chuka County Referral Hospital in Tharaka Nithi County. Methodology: A total of 272 participants, both hypertensive and normotensive, were recruited and blood samples obtained. DNA was extracted and analyzed by PCR RFLP. Independent T-test, Mann Whitney U test and Odds ratios were used to compare the two groups. P values less than 0.05 were considered statistically significant. Results: Median values for Red Cell Distribution Width (RDW), C-reactive Protein (CRP) and mean values for Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte ratio (NLR) were significantly higher (P < .001) in hypertensive group compared to normotensive individuals. Mean Platelet Distribution Width (PDW) was not significantly different between cases and controls. (P=.519) There was no significant association between the AGTR1 1166A>C (rs5186) SNP frequency and EH in both groups (P=0.6236, OR=0.4952(95%CI:0.0442-5.5456) Conclusion: The AGTR1 (rs5186) SNP is not associated with EH in Tharaka Nithi County, Kenya. EH is associated with elevated levels of CRP, RDW, MPV and NLR in the absence of other inflammatory and chronic diseases. Further studies of the genetics of hypertension in Kenya need to be conducted.
背景:原发性高血压(EH)占全球高血压病例的大多数。遗传因素以及血液学和生化变化可能是EH的基础,这些因素在肯尼亚尚未得到很好的研究。一项针对非洲人群(不包括东非)的荟萃分析发现,编码血管紧张素II 1型受体的血管紧张素II 1型受体基因(AGTR1)中的1166A>C (rs5186)单核苷酸多态性(SNP)可能使一些非洲人易患高血压。目的:该研究的目的是确定AGTR1 (rs5186)突变、c反应蛋白(CRP)和选定的血液学生物标志物是否与肯尼亚Tharaka Nithi县EH的发病有关。研究设计:采用病例对照研究设计。研究地点和时间:研究于2022年3月至7月在Tharaka Nithi县Chuka县转诊医院进行。方法:共招募了272名参与者,包括高血压和正常血压者,并获得了血液样本。提取DNA并进行PCR RFLP分析。采用独立t检验、Mann Whitney U检验和优势比对两组进行比较。P值小于0.05认为有统计学意义。结果:高血压组红细胞分布宽度(RDW)、c反应蛋白(CRP)的中位数、平均血小板体积(MPV)和中性粒细胞/淋巴细胞比(NLR)的平均值均显著高于正常组(P < 0.001)。平均血小板分布宽度(PDW)在病例和对照组之间无显著差异。两组患者AGTR1 1166A>C (rs5186) SNP频率与EH无显著相关性(P=0.6236, OR=0.4952(95%CI:0.0442 ~ 5.5456)。结论:肯尼亚Tharaka Nithi县AGTR1 (rs5186) SNP与EH无相关性。在没有其他炎症和慢性疾病的情况下,EH与CRP、RDW、MPV和NLR水平升高有关。需要对肯尼亚高血压的遗传学进行进一步的研究。
{"title":"Selected haematological markers and C-reactive protein, not AGTR1 SNP, are associated with essential hypertension in Tharaka Nithi County, Kenya","authors":"A. Mbaabu, Caroline Mangare, Collins Wangulu, Amos Mbugua","doi":"10.9734/ajmah/2023/v21i10875","DOIUrl":"https://doi.org/10.9734/ajmah/2023/v21i10875","url":null,"abstract":"Background: Essential Hypertension (EH) accounts for majority of hypertension cases globally. Genetic factors along with haematological and biochemical changes may underlie EH and these have not been well studied in Kenya. A meta-analysis in African populations (excluding East Africa) identified the 1166A>C (rs5186) single nucleotide polymorphism (SNP) in the angiotensin II type 1 receptor gene (AGTR1) that encodes the angiotensin II type 1 receptor as likely to predispose some Africans to hypertension. \u0000Aim: The purpose of the study was to determine whether the AGTR1 (rs5186) mutation, C-reactive protein (CRP) and selected haematological biomarkers may be associated with the onset of EH in Tharaka Nithi County, Kenya). \u0000Study Design: A case control study design was adopted. \u0000Place and Duration of Study: The research was conducted from March to July 2022 at Chuka County Referral Hospital in Tharaka Nithi County. \u0000Methodology: A total of 272 participants, both hypertensive and normotensive, were recruited and blood samples obtained. DNA was extracted and analyzed by PCR RFLP. Independent T-test, Mann Whitney U test and Odds ratios were used to compare the two groups. P values less than 0.05 were considered statistically significant. \u0000Results: Median values for Red Cell Distribution Width (RDW), C-reactive Protein (CRP) and mean values for Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte ratio (NLR) were significantly higher (P < .001) in hypertensive group compared to normotensive individuals. Mean Platelet Distribution Width (PDW) was not significantly different between cases and controls. (P=.519) There was no significant association between the AGTR1 1166A>C (rs5186) SNP frequency and EH in both groups (P=0.6236, OR=0.4952(95%CI:0.0442-5.5456) \u0000Conclusion: The AGTR1 (rs5186) SNP is not associated with EH in Tharaka Nithi County, Kenya. EH is associated with elevated levels of CRP, RDW, MPV and NLR in the absence of other inflammatory and chronic diseases. Further studies of the genetics of hypertension in Kenya need to be conducted.","PeriodicalId":49491,"journal":{"name":"Southeast Asian Journal of Tropical Medicine and Public Health","volume":"25 5 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81024525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dementia Diagnosis and Alternate Treatment: A Recent Update on Treatment Options 痴呆诊断和替代治疗:治疗方案的最新进展
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-18 DOI: 10.9734/ajmah/2023/v21i10874
U. Gupta, T. N. Shafin, Nuzhat Rahman, Elora Chakraborty, Manisha Deb, Tahira Ferdous
Dementia is a global health burden identified by the World Health Organization in its global action plan on the public health response to dementia 2017-2025. Our study aims to determine the efficacy of treatment options in Alzheimer’s disease and related dementia (ADRD). The initiation of dementia treatment has consistently posed a significant dilemma for healthcare professionals, necessitating careful consideration when selecting the appropriate group of medications to commence therapy, considering the specific type of treatment required. To conduct our study, we searched PubMed Central and the Cochrane database to identify comparative trials that compared different dementia treatment options. Our objective was to evaluate the effectiveness of various treatment approaches across different types of dementia. In total, we reviewed over 40 papers that provided valuable insights into the comparative outcomes of these treatment options. In our analysis, we have found mild to moderate cognitive dysfunction (MMSE 19 to 26) and newly diagnosed Alzheimer's disease can be treated with a trial of Cholinesterase inhibitors (Donepezil, Galantamine, and Rivastigmine); choice can be based on clinician and/or patient preference, as efficacy is similar. Moderate to advanced dementia (MMSE 10 to 18): Memantine (10 mg twice daily) is a suggested option with Cholinesterase inhibitors. In conclusion, it is evident that the available options for dementia medication are inherently limited, while the resources allocated to evaluate further treatment alternatives remain constrained. As a result, there is an urgent need to prioritize additional research and comprehensive assessment in this field.
痴呆症是世界卫生组织在其《2017-2025年公共卫生应对痴呆症全球行动计划》中确定的一项全球健康负担。本研究旨在确定阿尔茨海默病及相关痴呆(ADRD)治疗方案的疗效。痴呆症治疗的开始一直是医疗保健专业人员面临的一个重大困境,在选择适当的药物组开始治疗时,需要仔细考虑所需的具体治疗类型。为了开展我们的研究,我们检索了PubMed Central和Cochrane数据库,以确定比较不同痴呆治疗方案的比较试验。我们的目的是评估各种治疗方法对不同类型痴呆的有效性。总的来说,我们回顾了40多篇论文,这些论文对这些治疗方案的比较结果提供了有价值的见解。在我们的分析中,我们发现轻度至中度认知功能障碍(MMSE 19至26)和新诊断的阿尔茨海默病可以用胆碱酯酶抑制剂(多奈哌齐、加兰他明和利瓦斯替明)治疗;由于疗效相似,可根据临床医生和/或患者的偏好进行选择。中度至晚期痴呆(MMSE 10至18):美金刚(10mg,每日两次)是胆碱酯酶抑制剂的推荐选择。总之,很明显,痴呆症药物的可用选择本质上是有限的,而用于评估进一步治疗方案的资源仍然有限。因此,迫切需要优先考虑这一领域的进一步研究和全面评估。
{"title":"Dementia Diagnosis and Alternate Treatment: A Recent Update on Treatment Options","authors":"U. Gupta, T. N. Shafin, Nuzhat Rahman, Elora Chakraborty, Manisha Deb, Tahira Ferdous","doi":"10.9734/ajmah/2023/v21i10874","DOIUrl":"https://doi.org/10.9734/ajmah/2023/v21i10874","url":null,"abstract":"Dementia is a global health burden identified by the World Health Organization in its global action plan on the public health response to dementia 2017-2025. Our study aims to determine the efficacy of treatment options in Alzheimer’s disease and related dementia (ADRD). The initiation of dementia treatment has consistently posed a significant dilemma for healthcare professionals, necessitating careful consideration when selecting the appropriate group of medications to commence therapy, considering the specific type of treatment required. To conduct our study, we searched PubMed Central and the Cochrane database to identify comparative trials that compared different dementia treatment options. Our objective was to evaluate the effectiveness of various treatment approaches across different types of dementia. In total, we reviewed over 40 papers that provided valuable insights into the comparative outcomes of these treatment options. In our analysis, we have found mild to moderate cognitive dysfunction (MMSE 19 to 26) and newly diagnosed Alzheimer's disease can be treated with a trial of Cholinesterase inhibitors (Donepezil, Galantamine, and Rivastigmine); choice can be based on clinician and/or patient preference, as efficacy is similar. Moderate to advanced dementia (MMSE 10 to 18): Memantine (10 mg twice daily) is a suggested option with Cholinesterase inhibitors. In conclusion, it is evident that the available options for dementia medication are inherently limited, while the resources allocated to evaluate further treatment alternatives remain constrained. As a result, there is an urgent need to prioritize additional research and comprehensive assessment in this field.","PeriodicalId":49491,"journal":{"name":"Southeast Asian Journal of Tropical Medicine and Public Health","volume":"2 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86161372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative Appendectomy Rates -Current Prospective- A Review 阑尾切除术阴性率-当前前瞻性-综述
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-15 DOI: 10.9734/ajmah/2023/v21i10873
H. R. Kumar, M. Soma
The negative appendectomy rate is generally accepted in the diagnosis of acute appendicitis to prevent complications like perforation. This rate varies according to countries in western and eastern regions of the world. Clinical scoring systems, inflammatory markers and imaging have been used to reduce the negative appendectomy rate. The introduction of computerized tomography has improved the diagnostic accuracy of acute appendicitis. As this rate has been progressively decreasing over the past few years, a review article was done to look at the role of scoring systems, inflammatory markers, and imaging in diagnosing acute appendicitis and hence reduce the negative appendectomy rate.
在诊断急性阑尾炎时,一般采用阴性的阑尾切除率,以防止穿孔等并发症的发生。这一比率因世界西部和东部地区的国家而异。临床评分系统,炎症标志物和影像学已被用于降低阑尾切除术阴性率。计算机断层扫描的引入提高了急性阑尾炎的诊断准确性。由于这一比率在过去几年中逐渐下降,我们做了一篇综述文章来研究评分系统、炎症标志物和影像学在诊断急性阑尾炎中的作用,从而降低阑尾切除术阴性率。
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引用次数: 0
Effect of Using Midazolam and Propofol in Low Doses for Intraoperative Nausea and Vomiting Prevention in Pregnant Women Underwent Cesarean Section under Regional Anesthesia 低剂量咪达唑仑与异丙酚预防剖宫产术中恶心呕吐的效果
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-07-14 DOI: 10.9734/ajmah/2023/v21i10872
Zainab Faisal Habasha
Aim: To investigate if and how severe intraoperative nausea and vomiting occur following elective cesarean sections performed under spinal anesthesia using sub-hypnotic dosages of midazolam and propofol. Study Design: Clinical trial. Methodology:  The current study was conducted at the Gynecology and Obstetrics Department of a Teaching Hospital in Baghdad, Iraq. The study included 90 full-term pregnant women with single viable fetuses who underwent elective C/S by spinal anesthesia and were randomly assigned to one of three groups: group A included 30 women who received propofol, group B included 30 women who received midazolam, and Group C included 30 women who received placebo. The Bellville scoring score was used to assess nausea and vomiting. The Richmond Agitation Sedation Score (RASS) was used to assess sedation intraoperatively. Results: Patients in group C had the highest prevalence of nausea and vomiting (56.7%), which was significantly different from groups A (16.7%, P=0.001) and B (13.3%, P=0.001); however, there was no statistically significant difference between groups A and B (P= 0.717). The group B patients had the highest prevalence of drowsiness (20%), which was substantially different from group C (3.3%, P=0.044), whereas there were no statistically significant differences between groups A and B (P= 0.278) or A and C (P= 0.3). Conclusion: Low doses of midazolam or propofol administered after cesarean section (after the umbilical cord has been clamped) can lessen intraoperative nausea and vomiting without significantly lowering blood pressure or heart rate, with midazolam being more effective than propofol in this regard.
目的:探讨腰麻下咪达唑仑和异丙酚亚催眠剂量下择期剖宫产术中是否以及如何发生严重术中恶心和呕吐。研究设计:临床试验。方法:目前的研究是在伊拉克巴格达一家教学医院的妇产科进行的。该研究包括90名通过脊髓麻醉进行选择性C/S的单活胎足月孕妇,随机分为三组:A组有30名接受异丙酚的妇女,B组有30名接受咪达唑仑的妇女,C组有30名接受安慰剂的妇女。使用Bellville评分来评估恶心和呕吐。采用Richmond躁动镇静评分(RASS)评价术中镇静作用。结果:C组患者恶心呕吐发生率最高(56.7%),显著高于A组(16.7%,P=0.001)和B组(13.3%,P=0.001);A组与B组比较差异无统计学意义(P= 0.717)。B组患者嗜睡发生率最高(20%),与C组(3.3%,P=0.044)差异有统计学意义,而A组与B组(P= 0.278)、A组与C组(P= 0.3)差异无统计学意义。结论:剖宫产术后(钳住脐带后)给予低剂量咪达唑仑或异丙酚可减轻术中恶心呕吐,但不会显著降低血压和心率,在这方面咪达唑仑比异丙酚更有效。
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引用次数: 0
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Southeast Asian Journal of Tropical Medicine and Public Health
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