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The Relationship of Knowledge, Practices, and Culture on Low Coverage of Exclusive Breastfeeding 纯母乳喂养覆盖率低与知识、实践和文化的关系
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-06-10 DOI: 10.9734/ajmah/2023/v21i9850
Marniati, T. Alamsyah, Sufyan Anwar, Itza Mulyani, E. Putri
Aims: The aims of this study was to analyze the influence of knowledge Practices and,Culture on the low coverage of exclusive breastfeeding. Introduction: Exclusive breastfeeding is breastfeeding as early as possible after delivery, given without schedule, and not given other food even if only water until the baby is six months old. Development Agency of the Indonesian Ministry of Health said Exclusive Breastfeeding in Aceh Province is 41.0%, the coverage of breastfeeding in Aceh Province is very low and has not reached the target set by the Indonesian Ministry of Health, which is 80%. West Aceh's exclusive breastfeeding coverage 44%, exclusive breastfeeding coverage is still far from the target. The Meutulang region for two consecutive years still has the same achievement rate of 13.4%. Study Design: Cross-Sectional Survey approach. Location and Duration of Study: Conducted in December 2022 (15 November-20 Desember) in Meutulang District, West Aceh, Aceh, Indonesia. Methods: The population of all mothers who have babies aged 6-12 months. Sampling by the total sampling method, where all polluters were sampled as many as 44 respondents were. Furthermore, the data were analyzed using univariate and bivariate and then tested with a Simple Linear Regression Model. Results: proved that there is an influence of knowledge, action, and culture on the low coverage of exclusive breastfeeding as evidenced by the correlation value (R) of 0.601 and the value of the coefficient of determination (R²) of 0.464, which means that the influence of the independent variable on the dependent variable is 46.4% where the correlation between the independent and dependent variables is in a strong category with value (Pvalue <0.05). Conclusion: There was an influence of knowledge with value (Pvalue 0.011<0.05), value action (Pvalue 0.028<0.05), and value culture (Pvalue 0.000<0.05) on the low coverage of exclusive breastfeeding. Suggestions: There needs to be more intense socialization and enlightenment by relevant officers in terms of mothers' understanding of exclusive breastfeeding so that mothers consider exclusive breastfeeding more important and can analyze the culture around them to give breast milk to their babies at least until the age of 6 months.
目的:本研究的目的是分析知识、实践和文化对纯母乳喂养覆盖率低的影响。简介:纯母乳喂养是在婴儿出生后尽早进行母乳喂养,没有时间表,在婴儿六个月大之前不给其他食物,即使只有水。印度尼西亚卫生部发展署表示,亚齐省的纯母乳喂养覆盖率为41.0%,亚齐省的母乳喂养覆盖率非常低,尚未达到印度尼西亚卫生部设定的80%的目标。西亚齐的纯母乳喂养覆盖率为44%,纯母乳喂养覆盖率仍远未达到目标。梅土郎地区连续两年的完成率仍然保持在13.4%的水平。研究设计:横断面调查方法。研究地点和时间:于2022年12月(11月15日至12月20日)在印度尼西亚亚齐省西亚齐省Meutulang区进行。方法:所有有6-12个月婴儿的母亲。抽样采用总抽样法,对所有污染者抽样,最多抽样44个答复者。此外,采用单变量和双变量分析数据,然后用简单线性回归模型进行检验。结果:证明了知识、行为和文化对纯母乳喂养覆盖率低的影响,相关值(R)为0.601,决定系数(R²)为0.464,即自变量对因变量的影响为46.4%,自变量与因变量之间的相关性处于强值范畴(p值<0.05)。结论:有价值的知识(p值为0.011<0.05)、有价值的行动(p值为0.028<0.05)、有价值的培养(p值为0.000<0.05)对纯母乳喂养覆盖率低有影响。建议:在母亲对纯母乳喂养的认识方面,需要加强相关人员的社会化和启蒙,使母亲更加重视纯母乳喂养,并能分析周围的文化,至少在6个月之前给宝宝喂奶。
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引用次数: 0
Neterthon Syndrome Revealed by Recurrent Skin Infections: A Case Report 复发性皮肤感染引起的内特顿综合征1例报告
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-06-10 DOI: 10.9734/ajmah/2023/v21i8857
Ghizlane Jaabouti, N. Hafidi, C. Mahraoui
Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of symptoms including a scaly skin condition known as circumflex linear ichthyosis, hair shaft abnormalities known as trichorrhexis invaginata, and an atopic terrain which predisposes patients to allergic reactions and asthma. The disorder is caused by mutations in the SPINK5 gene which encodes for a serine protease inhibitor called LEKTI. This leads to a disruption in the skin's natural barrier function and a hyperactive immune response, resulting in the characteristic symptoms of NS. Newborns with NS may have a poor prognosis, with possible life-threatening complications and high postnatal lethality. However, the symptoms can improve with age and growth, and management of the disorder is aimed at controlling the symptoms and preventing complications such as infections. Symptomatic treatment for cutaneous xerosis and management of infections are commonly used. Additionally, topical emollients and systemic immunoglobulin therapy may be used to help manage the condition. We present a clinical case that can help raise awareness about rare diseases such as Netherton syndrome and improve early diagnosis and management. It is important for healthcare providers to be familiar with the clinical and etiological characteristics of these conditions to ensure that patients receive appropriate care and treatment. The reported case is an infant of 3 months old, who presents from the age of 2 months a cutaneous xerosis under the care of a dermatologist, and managed by symptomatic treatment. Based on the clinical presentation and examination (The hair trichoscopy), the infant have Netherton syndrome with a superimposed bacterial infection leading to ichthyosis linearis circumflexa superinfected.
内瑟顿综合征(NS)是一种罕见的常染色体隐性遗传病,其特征为三联性症状,包括鳞状皮肤状况,称为旋线状鱼鳞病,毛干异常,称为内阴毛癣,以及易使患者发生过敏反应和哮喘的特应性地。这种疾病是由SPINK5基因突变引起的,该基因编码一种名为LEKTI的丝氨酸蛋白酶抑制剂。这导致皮肤天然屏障功能的破坏和过度活跃的免疫反应,导致NS的特征症状。患有NS的新生儿预后可能较差,并可能出现危及生命的并发症和较高的产后死亡率。然而,症状会随着年龄的增长而改善,对这种疾病的治疗旨在控制症状和预防感染等并发症。对皮肤干燥症的对症治疗和感染的管理是常用的。此外,局部润肤剂和全身免疫球蛋白治疗可用于帮助控制病情。我们提出一个临床病例,可以帮助提高对内瑟顿综合征等罕见疾病的认识,并改善早期诊断和管理。对于医疗保健提供者来说,熟悉这些疾病的临床和病因特征以确保患者得到适当的护理和治疗是很重要的。报告的病例是一名3个月大的婴儿,在皮肤科医生的护理下,从2个月开始出现皮肤干燥症,并通过对症治疗加以控制。根据临床表现和检查(毛发镜检查),婴儿患有内瑟顿综合征并叠加细菌感染,导致环状线状鱼鳞病重复感染。
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引用次数: 0
Stevens-Johnson Syndrome Secondary to Herpetic Infection: A Case Report 疱疹感染继发史蒂文斯-约翰逊综合征1例报告
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-06-10 DOI: 10.9734/ajmah/2023/v21i8858
Ghizlane Jaabouti, Soumia Bencchakroun, C. Mahraoui, N. Hafidi
Stevens-Johnson syndrome (SJS) is a rare but serious drug reaction characterized by extensive necrosis of the skin and mucous membranes. It is considered a medical emergency and requires immediate medical intervention, with a high mortality rate, especially during the acute phase. Symptoms of Stevens-Johnson syndrome include a rash, blisters, and lesions in the oral mucosa, throat, genitals, and eyes. Before the rash appears, symptoms such as fever, headache, muscle pain, and flu-like signs may occur. While the causes of Stevens-Johnson syndrome are not fully understood, it is often associated with an allergic reaction to medication. In children, it can also have an infectious origin. Survivors of Stevens-Johnson syndrome may experience long-term sequelae, including cutaneous, ophthalmological, genital, oral-dental, and psychological issues. Therefore, monitoring and early detection are crucial. The severity of this pathology makes the reported case particularly compelling. It highlights the importance of medical personnel having knowledge and mastery of this condition in order to improve management and prognosis. We report the case of an 8-year-old child who presented with a pseudogripal syndrome that rapidly progressed in 24 hours to an exanthem characterized by macules in pseudo-rings. The condition was complicated by a severe, diffuse enanthem and resulted in detachment with a positive Nikolsky sign. The clinical and biological evolution was favorable under symptomatic treatment, antiviral medication and intravenous immunoglobulin infusion.Top of Form
史蒂文斯-约翰逊综合征(SJS)是一种罕见但严重的药物反应,其特征是皮肤和粘膜广泛坏死。它被认为是一种医疗紧急情况,需要立即进行医疗干预,死亡率很高,特别是在急性期。史蒂文斯-约翰逊综合征的症状包括皮疹、水泡和口腔粘膜、喉咙、生殖器和眼睛的病变。在皮疹出现之前,可能会出现发烧、头痛、肌肉疼痛和流感样症状。虽然史蒂文斯-约翰逊综合征的病因尚不完全清楚,但它通常与药物过敏反应有关。在儿童中,它也可能有传染源。史蒂文斯-约翰逊综合征的幸存者可能会经历长期的后遗症,包括皮肤、眼科、生殖器、口腔牙科和心理问题。因此,监测和早期发现至关重要。这种病理的严重性使得报告的病例特别引人注目。它强调了医务人员了解和掌握这种情况,以改善管理和预后的重要性。我们报告的情况下,一个8岁的孩子谁提出了假性gripal综合征,在24小时内迅速进展到一个以伪环斑疹为特征的exanthem。病情因严重的弥漫性鼻炎而复杂化,并导致分离,伴有阳性的尼古斯基征。在对症治疗、抗病毒药物治疗和静脉注射免疫球蛋白治疗下,临床和生物学进展良好。表格顶部
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引用次数: 0
Perceptions Regarding Occupational Health and Safety Attitudes of Hospital Pharmacists in Ambulatory Care in Pakistan 巴基斯坦医院药剂师在门诊护理中的职业健康和安全态度
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-06-10 DOI: 10.9734/ajmah/2023/v21i8849
Ayisha Hashmi, N. Nadeem, Khulda E. Zahra, M. Malik, A. Hussain
Background: Standards for assessing and monitoring occupational health risks and safety measures for hospital pharmacists have been given prime importance in developed countries. However, occupational health and safety has often been neglected in developing countries. Lack of knowledge, poor training practices and insufficient resources are few of the reasons behind poor occupational health standards. Objective: The objective of the study was to assess perceptions regarding occupational health and safety attitudes of hospital pharmacists in ambulatory care in Pakistan. Methodology: A descriptive cross-sectional study design was used. The study respondents included hospital pharmacists working in Islamabad and Rawalpindi. Sample size was calculated to be 382 to achieve 95% confidence level with 5% margin of error. Convenient sampling technique was used to select respondents. A pre-validated tool Safety Attitudes Questionnaire-Ambulatory Version was used. Data was coded and analyzed using SPSS 21 after collection. Descriptive statistics comprising of frequency and percentages were calculated. Mann-Whitney and Kruskal-Wallis (p ≥ 0.05) tests were applied according to different demographic variables. Results: Significant difference (p<0.05) was observed in perceptions of occupational health and safety attitudes in ambulatory care among respondents of different genders, cities, education level, age groups, experience, setting and salary. Females had poor safety attitudes in ambulatory care as compared to male respondents. Respondents having experience between 1-5 years had poor safety attitude as compared to other respondents. Respondents working in private sector had poor occupational health and safety attitudes as compared to those working in public sector. Conclusion: The present study concluded that hospital pharmacists working in ambulatory care had satisfactory occupational health and safety attitudes. Respondents agreed that they had made errors due to workplace pressures and workload. Trainings should be conducted to improve the occupational health and safety attitudes of hospital pharmacists in ambulatory care.
背景:在发达国家,评估和监测医院药剂师职业健康风险的标准和安全措施已经得到了高度重视。然而,职业健康和安全在发展中国家往往被忽视。缺乏知识、不良培训做法和资源不足是造成职业卫生标准差的几个原因。目的:本研究的目的是评估巴基斯坦医院药剂师在门诊护理中的职业健康和安全态度。方法:采用描述性横断面研究设计。调查对象包括在伊斯兰堡和拉瓦尔品第工作的医院药剂师。计算样本量为382,达到95%的置信水平,误差范围为5%。采用方便抽样方法选择调查对象。使用预先验证的工具安全态度问卷-流动版。收集数据后使用SPSS 21进行编码和分析。计算由频率和百分比组成的描述性统计。根据不同人口统计学变量采用Mann-Whitney和Kruskal-Wallis检验(p≥0.05)。结果:不同性别、不同城市、不同文化程度、不同年龄、不同工作经历、不同工作环境、不同工资水平的被调查者对门诊护理职业健康安全态度的认知差异有统计学意义(p<0.05)。与男性受访者相比,女性对门诊护理的安全态度较差。与其他受访者相比,有1-5年工作经验的受访者对安全的态度较差。与在公共部门工作的答复者相比,在私营部门工作的答复者对职业健康和安全的态度较差。结论:医院门诊药师职业健康安全态度良好。受访者一致认为,由于工作压力和工作量,他们犯了错误。应开展培训,提高医院门诊药师的职业健康安全态度。
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引用次数: 0
Low Viral Load Testing in HIV Patients on Antiretroviral Therapy: Mitigation Measures in Ghana 接受抗逆转录病毒治疗的艾滋病毒患者的低病毒载量检测:加纳的缓解措施
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-06-07 DOI: 10.9734/ajmah/2023/v21i8847
M. Asumah, A. Abubakari, M. Mutaka, D. Donkor, Raphael Abolasom Kumah
The “Type of Article” of this paper is “Letter to the Editor”. This paper discuses about: “Low Viral Load Testing in HIV Patients on Antiretroviral Therapy: Mitigation Measures in Ghana”. No formal abstract is available. Readers are requested to read the full article.
这篇报纸的“文章类型”是“给编辑的信”。本文讨论了“抗逆转录病毒治疗艾滋病患者的低病毒载量检测:加纳的缓解措施”。没有正式的摘要。请读者阅读全文。
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引用次数: 0
Comparing Diagnostic Accuracy of USG and CT Scan in Detecting Fatty Liver in Indonesian Patients: Implications for Screening and Management 比较USG和CT在印尼脂肪肝诊断中的准确性:对筛查和管理的意义
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-06-03 DOI: 10.9734/ajmah/2023/v21i8846
Anggraheny Soelistyaningtyas
This study aimed to determine the accuracy of non-contrast USG and CT Scan in diagnosing fatty liver in Indonesian patients. Using a diagnostic test design with a cross-sectional approach, patients aged 40 years or older with laboratory examination results supporting NAFLD were selectively chosen from Dr. Soetomo Surabaya Hospital's Radiology Laboratory during February-March 2020. The study found that there is no significant difference in diagnostic accuracy between non-contrast USG and CT Scan in detecting NAFLD. Moreover, the majority of patients with NAFLD were women, and the highest prevalence was observed in the middle age range of 40-49 years. These findings suggest that clinicians should consider these demographic characteristics when screening and managing NAFLD in their patients. The choice of diagnostic test should be based on factors such as availability, cost, and patient preference.
本研究旨在确定非对比USG和CT扫描诊断印度尼西亚脂肪肝患者的准确性。使用横断面方法的诊断试验设计,在2020年2月至3月期间从Soetomo泗水医生医院放射学实验室选择性地选择40岁或以上的实验室检查结果支持NAFLD的患者。本研究发现非造影剂USG与CT扫描对NAFLD的诊断准确率无显著差异。此外,大多数NAFLD患者为女性,40-49岁的中年患病率最高。这些发现提示临床医生在筛查和处理NAFLD患者时应考虑这些人口统计学特征。诊断测试的选择应基于诸如可获得性、成本和患者偏好等因素。
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引用次数: 0
Association of Psychological Distress with Primary Dysmenorrhea among Adolescents Living in West Bengal, India 印度西孟加拉邦青少年心理困扰与原发性痛经的关系
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-05-24 DOI: 10.9734/ajmah/2023/v21i8842
Payel Pramanik, Purushottam Pramanik
Background: Primary dysmenorrhea, a painful uterine cramp without any pelvic pathology that occur before or during menstruation among reproductive women. Objective: The objective of this study was to compare the psychological distress between adolescent female students with dysmenorrhea and without dysmenorrhea and also to examine relationship between psychological distress and dysmenorrhea. Methods: This is a cross sectional questionnaire based study conducted among 1646 adolescent female having age limit 14-19 years. Only unmarried adolescent females were included in the study however, females with gynecological, psychological or other medical problems were excluded from the study. It used validated and reliable questionnaire such as VAS for pain rating scale and DASS-21 for assessment of depression, anxiety, stress. Then, the descriptive data analysis and chi-square test were used to explore the relationship between psychological distress and dysmenorrhea. t-test was used to compare psychological distress between dysmenorrhea and non-dysmenorrhea. P<0.05 was considered as significant. Results: Mean age of the adolescent female was 15.91+ 1.27 years. Prevalence of dysmenorrhea was 88.94%. Among dysmenorrhea 22.40% was severe, 28.89% was under moderate and   48.71% was under mild dysmenorrhea. There was significant difference of psychological distress indices scores between dysmenorrhea and non-dysmenorrhea (p<0.001). Majority of dysmenorrheic females had severe to extreme severe levels of anxiety, depression and stress in contrast to non-dysmenorrheic females who have mild to moderate level. Significant association was noted between depression, anxiety, mental irritability and mood swing with primary dysmenorrhea (p<0.001). Conclusion: The present study suggested that dysmenorrhea is associated with psychological distress including anxiety, depression, mental irritation and mood swing. Psychological interventions and counselling are important for young women with primary dysmenorrhea to lessen the severity of menstrual pain.
背景:原发性痛经是一种疼痛性子宫痉挛,无盆腔病变,发生在育龄妇女月经前或月经期间。目的:比较有痛经和无痛经的青春期女大学生的心理困扰情况,探讨心理困扰与痛经的关系。方法:采用横断面问卷调查法,对1646名年龄在14 ~ 19岁的青少年女性进行调查。只有未婚的青春期女性被纳入研究,但有妇科、心理或其他医学问题的女性被排除在研究之外。采用经验证可靠的问卷,如疼痛评定量表VAS和抑郁、焦虑、压力量表das -21。然后采用描述性资料分析和卡方检验探讨心理困扰与痛经的关系。采用t检验比较痛经与非痛经患者的心理困扰程度。P<0.05为差异有统计学意义。结果:青少年女性平均年龄15.91+ 1.27岁。痛经发生率为88.94%。重度痛经占22.40%,中度痛经占28.89%,轻度痛经占48.71%。痛经组与非痛经组的心理困扰指数评分差异有统计学意义(p<0.001)。大多数痛经女性有严重到极严重程度的焦虑、抑郁和压力,而非痛经女性只有轻度到中度的焦虑、抑郁和压力。抑郁、焦虑、精神烦躁和情绪波动与原发性痛经有显著相关性(p<0.001)。结论:痛经与焦虑、抑郁、精神刺激、情绪波动等心理困扰有关。心理干预和咨询是重要的年轻妇女原发性痛经减轻痛经的严重程度。
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引用次数: 1
Analysis of Radiation Dose Distribution and Organs at Risk in Breast Cancer Using Intensity Modulated Radiation Therapy Technique on A Linear Accelerator at RSUP Prof. Dr. I.G.N.G. Ngoerah 在RSUP线性加速器上使用调强放射治疗技术分析乳腺癌的辐射剂量分布和危险器官
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-05-23 DOI: 10.9734/ajmah/2023/v21i8840
Luqyana Latifa, N. Ratini, I. W. Sudarsana, Ida Bagus Made Suryatika, I. G. A. Ratnawati, A. Gunawan, R. Irhas
The aim of the study was to analyze the radiation dose distribution in breast cancer cases using IMRT techniques on a LINAC equipment, specifically examining the Conformity Index (CI), Homogeneity Index (HI), and radiation dose distribution to the OAR, including lungs and heart on a 6 MV photon beam energy LINAC equipment at the Radiotherapy Sub-Installation of Prof. Dr. I.G.N.G Ngoerah Hospital. Analysis of the Conformity Index (CI), Homogeneity Index (HI) and radiation dose distribution to the OAR, namely the lungs and heart in cases of right and left breast cancer using statistical data on the Dose Volume Histogram (DHV) graphic obtained from patient calculations using the Treatment Planning System (TPS) Monaco. The CI value for the right and left breast cancer cases is 0.9819 and 0.9942 respectively with a nonparametric statistical test result of 0.141 that greater than 0.05 which means it is not significant. Meanwhile, the HI values for the right and left breast cancer cases are 0.1211 and 0.1410 respectively with the multivariate statistical test result of 0.159 that greater than 0.05 which means it is not significant. For the dose distribution values in the lungs close and far from the cancer, the average values of 32.24% and 440.03 cGy for right breast cancer and 33.04% and 500.55 cGy for left breast cancer were obtained, respectively, with a multivariate statistical test value for both of them of 0.115 that greater than 0.05 in the lungs close to the cancer and 0.124≥0.05 in the lungs far from the cancer, which means insignificant. As for the heart, a value of 3.13% was obtained for right breast cancer and 8.02% for left breast cancer with a nonparametric statistical test result of 0.000 that less than 0.05 which means significant. This can be caused by the position of the heart in cases of left breast cancer closer to the target or cancer than cases of left breast cancer.
本研究的目的是分析在LINAC设备上使用IMRT技术的乳腺癌病例的辐射剂量分布,特别是检查合格指数(CI)、均匀指数(HI)和辐射剂量分布到OAR,包括肺和心脏,在6 MV光子束能量LINAC设备上,I.G.N.G Ngoerah教授医院放射治疗分站。利用摩纳哥治疗计划系统(TPS)计算得出的剂量体积直方图(DHV)统计数据,分析右乳腺癌和左乳腺癌患者肺和心脏的一致性指数(CI)、均匀性指数(HI)和辐射剂量分布。右侧乳腺癌和左侧乳腺癌的CI值分别为0.9819和0.9942,非参数统计检验结果为0.141,大于0.05,无统计学意义。同时,右侧乳腺癌和左侧乳腺癌的HI值分别为0.1211和0.1410,多变量统计检验结果为0.159,大于0.05,无统计学意义。近肺和远肺的剂量分布值,右侧乳腺癌的平均值分别为32.24%和440.03 cGy,左侧乳腺癌的平均值分别为33.04%和500.55 cGy,近肺的剂量分布值均为0.115大于0.05,远肺的剂量分布值均为0.124≥0.05,不显著。对于心脏,右乳腺癌为3.13%,左乳腺癌为8.02%,非参数统计检验结果0.000 < 0.05,为显著性。这可能是由于左乳腺癌患者的心脏位置比左乳腺癌患者更接近目标或癌症。
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引用次数: 0
Effect of Carbohydrate Type on Brain Composition and Senescence in Aging, Hyperinsulinemia-prone OBESE LA/Ntul//-cp Rats 碳水化合物类型对衰老、高胰岛素易感性肥胖LA/Ntul//-cp大鼠脑成分和衰老的影响
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-05-23 DOI: 10.9734/ajmah/2023/v21i8841
O. Tulp
To determine if phenotype and the carbohydrate type resulted in alterations in brain composition in the obese phenotype of the congenic LA/Ntul//-cp rat, groups (n= 8 rats/group) of male littermate lean and obese rats were fed standardized isocaloric diets containing 54% (w/w) cornstarch (ST diet) or 54% (w/w) sucrose (SUC diet) from 1 until 10.5 ± 0.5 months of age. The obese phenotype of his strain develops early onset chronic hyperinsulinemia without NIDDM associated with hypertrophic-hyperplastic obesity during early postweaning growth. Brain tissues were dissected, and representative aliquots subjected to total fat, protein, and DNA analysis. Body weights of obese >> lean and were greater when fed the SUC than the ST diet in both phenotypes. Brain mass of lean > obese, and diet was associated with modestly lower brain weights in rats fed the SUC than the ST diet. Brain total Protein and DNA content of lean rats were > obese rats and were modestly Lower in SUC than ST fed rats in both phenotypes, but the percent of lipid content was proportional to brain mass. Total body fat mass of obese was significantly greater than occurred in lean littermates and was only modestly greater in SUC than ST fed rats in both phenotypes. These results indicate that brain growth and cellular development is impaired in the aging, hyperinsulinemia-prone obese phenotype of this strain, were further impaired when fed SUC than ST diets, and the decreased brain parameters were likely associated with development of a chronic neuronal inflammatory syndrome common to excessive fat accretion and obesity, resulting in premature brain senescence.
为了确定表型和碳水化合物类型是否导致肥胖表型的同源LA/Ntul//-cp大鼠脑成分的改变,在1 ~ 10.5±0.5月龄期间,分别饲喂含有54% (w/w)玉米淀粉(ST日粮)或54% (w/w)蔗糖(SUC日粮)的标准等热量饲料(n= 8只/组)。该品系的肥胖表型为早发性慢性高胰岛素血症,无NIDDM,在断奶后早期生长期间伴有肥厚-增生性肥胖。解剖脑组织,并对代表性的等分进行总脂肪、蛋白质和DNA分析。在这两种表型中,喂食SUC的肥胖、肥胖、瘦和瘦鼠的体重都比喂食ST的大。用SUC喂养的大鼠的脑质量比用ST喂养的大鼠的脑质量略低,与瘦、胖、肥胖和饮食有关。瘦肉大鼠的脑总蛋白和DNA含量是肥胖大鼠的一半,在两种表型中,SUC喂养的大鼠略低于ST喂养的大鼠,但脂质含量的百分比与脑质量成正比。在两种表型中,肥胖的鼠体脂肪总量明显大于瘦仔鼠,而SUC喂养的鼠体脂肪总量仅略高于ST喂养的大鼠。这些结果表明,在衰老,高胰岛素易感肥胖表型中,该品系的大脑生长和细胞发育受到损害,当喂食SUC而不是ST时,大脑参数的下降可能与过度脂肪堆积和肥胖常见的慢性神经元炎症综合征的发展有关,导致大脑过早衰老。
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引用次数: 0
Analysis of Radiation Dose Distribution in Nasopharyngeal and Organ Cancer Cases at Risk with Linear Accelerator Radiotherapy 6 MV Photon Energy Using the IMRT Technique at Prof. Hospital. Dr. I. G. N. G. Ngoerah 6 MV光子能量线性加速器放射治疗危重鼻咽癌及脏器癌的放射剂量分布分析I. G. N. G. Ngoerah博士
IF 0.2 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-05-18 DOI: 10.9734/ajmah/2023/v21i8838
Safitri Rahmaniyah, N. Ratini, I. W. Sudarsana, Ida Bagus Made Suryatika, K. N. Suarbawa, I. N. Artawan, A. Gunawan, R. Irhas
This study aims to determine the distribution of radiation doses on PTV and OAR radioteraphy planning in RSUP. Prof. Dr. I.G.N.G Ngoerah, Bali, Indonesia does no exceed a predetermined limit. The research metode used is the value of Homogenity Index (H), Conformity Index (CI), and the maximum value of radiation ose to the Organ At Risk (OAR), amely the right eye lens, left eye lens, brainstem, optic chiasma, and spinal cord. These data are compared with the provisions of ICRU report 83 and the maximum dose reference value for OAR. Using data from 30 nasopharyngeal cancer patients with a total radiation dose of 7000 cGy. Obtained a value for HI of 0.1214 with a t-test result of 0.459> 0.05 which means it is not significant. While the value for CI is 0.9850 with nonparametric statistical test results of 0.285> 0.05 which means it is not significant. The maximum dose value for the right eye lens is 772.7 cGy with a t-test result of 0.779> 0.05 which means it is not significant. For the maximum value of the dose in the lens of the left eye of 771.0 cGy with a t test result of 0.791> 0.05 which means it is not significant. For the maximum value of the dose in the brain stem of 5178.1 cGy with nonparametric test results of 0.686> 0.05 which means not significant. The maximum dose value at the optic chiasma is 4,837.2 cGy with a nonparametric test result of 0.225>0.05 which means it is not significant. For the maximum value of the dose in the spinal cord of 4,663.3 cGy with a t test result of 0.958> 0.05 which means it is not significant.
本研究旨在确定放射剂量在RSUP的PTV和OAR放射治疗计划中的分布。i.g.n.g. Ngoerah教授,印度尼西亚巴厘岛,不超过预定的限制。采用的研究方法为均匀性指数(H)、一致性指数(CI),以及对危险器官(OAR)即右眼晶状体、左眼晶状体、脑干、视交叉和脊髓的最大辐射损失值。这些数据与ICRU报告83的规定和OAR的最大剂量参考值进行了比较。使用总辐射剂量为7000 cGy的30例鼻咽癌患者的数据。得到HI值为0.1214,t检验结果0.459> 0.05,不显著。而CI值为0.9850,非参数统计检验结果为0.285> 0.05,说明不显著。右眼晶状体最大剂量值为772.7 cGy, t检验结果0.779> 0.05,不显著。左眼晶状体剂量最大值为771.0 cGy, t检验结果0.791> 0.05,不显著。对于脑干剂量的最大值为5178.1 cGy,非参数检验结果为0.686> 0.05,即不显著。在视交叉处的最大剂量值为4,837.2 cGy,非参数检验结果为0.225>0.05,不显著。脊髓内剂量最大值为4,663.3 cGy, t检验结果为0.958> 0.05,不显著。
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Southeast Asian Journal of Tropical Medicine and Public Health
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