Journal of Veterinary Internal Medicine最新文献_第2页

Survival of radioiodine treated hyperthyroid cats that are euthyroid and hypothyroid after treatment, and effect of levothyroxine supplementation on survival time of cats with iatrogenic hypothyroidism 放射性碘治疗后甲状腺功能亢进和甲状腺功能减退猫的生存及补充左旋甲状腺素对医源性甲状腺功能减退猫生存时间的影响

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-20 DOI: 10.1111/jvim.17295

Sarah E. Cox, Jennifer Wakeling, Teresa Hall, Tim L. Williams

Background

Hyperthyroid cats that are azotemic and hypothyroid after surgical or medical treatment have poor outcomes, and supplementation with levothyroxine (LT4) improves survival. However, the effect of LT4 supplementation on survival of nonazotemic, hypothyroid radioiodine (RI)-treated hyperthyroid cats is unknown.

Hypothesis

Radioiodine treated hyperthyroid cats with iatrogenic hypothyroidism or azotemia have shorter survival times than euthyroid, nonazotemic cats and supplementation of LT4 improves survival times of hypothyroid cats.

Animals

One hundred seventeen RI treated hyperthyroid cats.

Methods

Prospective cohort study. Radioiodine treated cats were screened for azotemia and iatrogenic hypothyroidism using TSH stimulation test; LT4 supplementation was offered to all hypothyroid cats with decision to treat based on owner preference. The log rank test was used to compare survival times between groups, and the Mann-Whitney U test was used to compare age and renal variables. Data are presented as median [range].

Results

Euthyroid azotemic cats (934 [759-2035] days) and nonsupplemented hypothyroid cats (azotemic and nonazotemic combined, 1232 [238-2363] days) had shorter survival times than euthyroid nonazotemic cats (1616 [663-3369] days, P = .003 and P = .002, respectively). Levothyroxine supplemented hypothyroid nonazotemic cats had longer survival times than nonsupplemented hypothyroid nonazotemic cats (1037 [300-2401] days vs 768 [34-1014] days; P = .027). Levothyroxine supplementation was not associated with prolonged survival times in hypothyroid azotemic cats vs nonsupplemented hypothyroid azotemic cats (771 [718-1558] days vs 152 [82-1852] days, respectively, P = .991).

Conclusions and Clinical Importance

Levothyroxine supplementation in nonazotemic cats with iatrogenic hypothyroidism (diagnosed based on TSH stimulation test results) improved survival times, although randomized controlled trials are needed.

背景：手术或药物治疗后azotemic和甲状腺功能减退的甲亢猫预后较差，补充左旋甲状腺素（LT4）可提高生存率。然而，补充LT4对非氮化、甲状腺功能低下的放射性碘（RI）治疗的甲状腺功能亢进猫的生存影响尚不清楚。假设：放射性碘治疗的甲状腺功能亢进猫合并医源性甲状腺功能减退或氮化症的生存时间比甲状腺功能正常和非氮化症的猫短，补充LT4可以提高甲状腺功能减退猫的生存时间。动物：117只RI治疗甲状腺功能亢进的猫。方法：前瞻性队列研究。用TSH刺激试验筛选放射性碘治疗猫氮血症和医源性甲状腺功能减退症；所有甲状腺功能减退的猫都补充了LT4，并根据主人的偏好决定治疗。采用log rank检验比较组间生存时间，采用Mann-Whitney U检验比较年龄和肾脏变量。数据以中位数[范围]表示。结果：甲状腺功能正常的猫（934[759-2035]天）和未补充的甲状腺功能低下的猫（氮化和非氮化合并，1232[238-2363]天）的生存时间比甲状腺功能正常的猫（1616[663-3369]天）短，P =。003, P =。002年,分别)。补充左甲状腺素的甲状腺功能减退猫比未补充左甲状腺素的甲状腺功能减退猫存活时间更长（1037[300-2401]天vs 768[34-1014]天）；p = 0.027)。与未补充左甲状腺素的低甲状腺氮化猫相比，补充左甲状腺素与延长生存时间无关（分别为771[718-1558]天和152[82-1852]天，P = .991）。结论和临床意义：尽管需要随机对照试验，但补充左旋甲状腺素对患有医源性甲状腺功能减退症（根据TSH刺激试验结果诊断）的非氮化猫的生存时间延长。

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引用次数: 0

Plasma amino acid profiles of dogs with the hepatocutaneous syndrome and dogs with other chronic liver diseases 肝皮综合征犬和其他慢性肝病犬的血浆氨基酸谱

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-20 DOI: 10.1111/jvim.17285

Rommaneeya Leela-arporn, Karah Burns DeMarle, Cailin R. Heinze, Cynthia R. L. Webster

Background

Dogs with hepatocutaneous syndrome (HCS) have marked plasma hypoaminoacidemia, but its occurrence in dogs with chronic liver diseases not associated with HCS (non-HCS CLD) is unknown.

Objectives

To determine if plasma hypoaminoacidemia occurs in dogs with non-HCS CLD, compare plasma amino acid (PAA) profiles between dogs with non-HCS CLD and HCS, and define a sensitive and specific PAA pattern for diagnosing HCS.

Animals

Data were collected from client-owned dogs, a prospective cohort of 32 with CLD and 1 with HCS, and a retrospective cohort of 7 with HCS.

Methods

Prospective study. Dogs with chronic serum liver enzyme increases were recruited after hepatic biopsy. Plasma amino acid profiles were measured using high-performance liquid chromatography. Plasma amino acid concentrations were compared between dogs with non-HCS CLD and HCS. Regression analysis was performed to identify a unique PAA pattern for HCS diagnosis.

Results

Twelve dogs each with vacuolar hepatopathy or chronic hepatitis and 8 dogs with congenital disorders (primary hypoplasia of the portal vein or ductal plate malformations) were enrolled. Compared to non-HCS CLD dogs, HCS dogs had significantly lower plasma concentrations of several amino acids. Regression analysis revealed that glutamine, glycine, citrulline, arginine, and proline concentrations less than 30% of the mean reference value had 100% sensitivity, specificity for diagnosing HCS.

Conclusions and Clinical Importance

Generalized plasma hypoaminoacidemia does not accompany non-HCS CLD. Concentrations of 5 specific amino acids less than 30% of the mean reference value can serve as a noninvasive biomarker for diagnosing HCS.

背景：患有肝皮综合征（HCS）的狗有明显的血浆低胺酸血症，但在与HCS无关的慢性肝病狗（非HCS CLD）中是否发生尚不清楚。目的：确定非HCS型CLD犬是否存在血浆低胺酸血症，比较非HCS型CLD犬与HCS型CLD犬的血浆氨基酸（PAA）谱，确定诊断HCS的敏感特异性PAA模式。动物：数据来自客户拥有的狗，32只CLD和1只HCS的前瞻性队列，7只HCS的回顾性队列。方法：前瞻性研究。在肝活检后招募慢性血清肝酶升高的狗。采用高效液相色谱法测定血浆氨基酸谱。比较非HCS型CLD和HCS型CLD犬的血浆氨基酸浓度。进行回归分析以确定HCS诊断的独特PAA模式。结果：空泡性肝病、慢性肝炎犬各12只，先天性疾病（门静脉原发性发育不全或导管板畸形）犬8只。与非HCS CLD狗相比，HCS狗的血浆中几种氨基酸浓度显著降低。回归分析显示，谷氨酰胺、甘氨酸、瓜氨酸、精氨酸和脯氨酸浓度低于平均参考值的30%，诊断HCS的敏感性和特异性为100%。结论及临床意义：广泛性血浆低胺酸血症不伴有非hcs型CLD。5种特定氨基酸浓度低于平均参考值的30%可作为诊断HCS的无创生物标志物。

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引用次数: 0

Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-20 DOI: 10.1111/jvim.17304

Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead

Background

The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood.

Objective

Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long-term course of orally administered prednisolone.

Animals

Eight healthy neutered young adult research Beagles.

Methods

In our prospective longitudinal study, Beagles were treated with a placebo PO q24h for 15 days (baseline), followed by a 35-day course of prednisolone (2.35-2.75 mg/kg PO q24h) and then abrupt discontinuation of prednisolone. Serial pAVP and sCoP concentrations, urine specific gravity (USG) and calculated plasma osmolality (pOsm_calculated) were determined during placebo and prednisolone administration, and up to 4 weeks after prednisolone discontinuation. Paired plasma samples for pAVP measurement were obtained in EDTA tubes with (pAVP_P800) and without (pAVP_EDTA) a proprietary combination of protease, esterase, and dipeptidyl peptidase-IV inhibitors (BD Biosciences P800).

Results

Mean pAVP_P800 and sCoP concentrations were significantly lower at the end of the prednisolone course (25.8 ± 8.1 pg/mL and 166 pg/mL, range, 131-223) vs baseline (34.1 ± 5.4 pg/mL and 243 pg/mL, range, 157-336; P = .02, P = .02, respectively). Correlations between pAVP_P800 and sCoP (r = .77, P = .001) and pAVP_P800 and USG (r = .61, P = .02) were positive, despite no correlation between pAVP_P800 and pOsm_calculated, sCoP and pOsm_calculated, and sCoP and USG. On paired samples, mean pAVP_EDTA was significantly lower (5.0 ± 2.5 pg/mL) than mean pAVP_P800 (34.1 ± 5.4 pg/mL; P < .0001).

Conclusions and Clinical Importance

Orally administered prednisolone led to markedly decreased plasma AVP and serum CoP concentrations despite increased calculated plasma osmolality and stable systolic blood pressure.

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引用次数: 0

Characterization of post-ictal clinical signs in dogs with idiopathic epilepsy: A questionnaire-based study 特发性癫痫犬发作后临床症状的特征：一项基于问卷的研究。

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-20 DOI: 10.1111/jvim.17302

Aran Nagendran, Julie A. Nettifee, Dani Carter, Karen R. Muñana

Background

Post-ictal (PI) clinical signs are a key defining stage of seizure manifestation in dogs. However, this phase remains poorly understood.

Objectives

To further characterize PI signs and their relation to other parts of a seizure, and understand the owner's perception of how PI signs affect the quality of life (QOL) of the dog.

Animals

Eight-seven dogs with a diagnosis of idiopathic epilepsy from a single institution.

Methods

The prospective questionnaire-based study surveying owners of dogs previously and newly diagnosed with idiopathic epilepsy.

Results

Post-ictal signs were identified in 79/87 dogs, 5/5 of dogs with focal seizures and 74/82 of dogs with generalized seizures. Median duration of PI signs was 30 minutes (range, 5-4320 minutes). The most common PI signs reported were disorientation (50/79) and wobbliness or clumsiness (49/79). Within a year, a change in PI signs was seen in 18/79 dogs. The administration of benzodiazepines was significantly associated with an increase in duration of PI signs (P = .04). Post-ictal signs had more impact on dogs' quality of life compared with ictal signs (P < .01). Groupings of co-existing PI signs identified included disorientation, blindness and deafness.

Conclusion

Post-ictal signs are a commonly reported aspect of seizures in dogs with idiopathic epilepsy, both in focal as well as generalized seizures. Co-existence of signs could provide some valuable insight into the relevance of this particular phase of a seizure. Owner-reported signs and documentation emphasize the need for a better understanding of PI signs in dogs with idiopathic epilepsy.

背景：癫痫发作后（PI）临床体征是犬癫痫表现的关键阶段。然而，人们对这一阶段仍然知之甚少。目的：进一步表征PI征象及其与癫痫发作其他部分的关系，并了解主人对PI征象如何影响狗的生活质量（QOL）的看法。动物：同一机构诊断为特发性癫痫的八十七只狗。方法：前瞻性问卷调查的基础上的研究调查狗的主人以前和新诊断为特发性癫痫。结果：有79/87的犬、5/5的局灶性癫痫发作犬和74/82的全身性癫痫发作犬发现了发作后体征。PI体征的中位持续时间为30分钟（范围5-4320分钟）。最常见的PI症状是迷失方向（50/79）和摇晃或笨拙（49/79）。一年内，79只狗中有18只出现PI变化。苯二氮卓类药物的使用与PI症状持续时间的增加显著相关（P = 0.04）。与癫痫发作体征相比，癫痫发作后体征对犬的生活质量影响更大(P结论：癫痫发作后体征是特发性癫痫犬癫痫发作的一个常见方面，无论是局灶性癫痫发作还是全身性癫痫发作。共存的迹象可以提供一些有价值的见解，相关性的这一特定阶段的癫痫发作。主人报告的体征和文献强调需要更好地了解特发性癫痫犬的PI体征。

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引用次数: 0

Effect of additional dimensions and views in the echocardiographic determination of 3-dimensional left ventricular volume in myxomatous mitral valve disease in dogs 超声心动图测定犬二尖瓣黏液瘤病左心室三维容积时附加尺寸和视图的影响。

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-11 DOI: 10.1111/jvim.17300

Weihow Hsue, Cortney E. Pelzek, Samantha Siess, Benjamin A. Terhaar, Shana B. Mintz, Romain Pariaut

Background

Left ventricular (LV) volumes can be calculated from various linear, monoplane, and multiplane echocardiographic methods, and the same method can be applied to different imaging views. However, these methods and their variations have not been comprehensively evaluated against real-time 3-dimensional echocardiography (RT3D).

Hypothesis/Objectives

To identify the LV volumetric approaches that produce the least bias and the best agreement with RT3D, and to assess interoperator reproducibility between an experienced and an inexperienced operator.

Animals

Fifty-nine client-owned dogs with myxomatous mitral valve disease (38 Stage B1, 13 Stage B2, 8 Stages C/D) received echocardiograms, with a subset of 28 dogs (14 Stage B1, 10 Stage B2, 4 Stages C/D) imaged by 2 operators.

Methods

Prospective method comparison study. Body weight-indexed end-diastolic and end-systolic LV volumes using linear methods in long- and short-axis views (Teichholz, cube, modified cube), monoplane methods in right parasternal and left apical views (area-length and Simpson's method of discs), biplane Simpson's method of discs, and real-time triplane (RT3P) were compared against RT3D.

Results

The RT3P method exhibited no bias and demonstrated the highest agreement with RT3D. The linear methods showed significant bias and lower agreements for end-diastolic volumes, end-systolic volumes, or both. Volumes derived from different imaging views using the same method showed poor agreement. Both RT3P and RT3D methods demonstrated poor interoperator reproducibility.

Conclusions and Clinical Importance

Incorporating additional dimensions improves bias and agreement in LV volume quantification, but comprehensive clinical experience with RT3P and RT3D is needed to improve consistency across all operators.

背景：左心室（LV）容积可以通过各种线性、单平面和多平面超声心动图方法计算，相同的方法可以应用于不同的成像视图。然而，这些方法及其变化尚未与实时三维超声心动图（RT3D）进行全面评估。假设/目标：确定与RT3D产生最小偏差和最佳一致性的左室容积测定方法，并评估有经验和没有经验的操作员之间的互操作可重复性。动物：59只患有黏液瘤性二尖瓣疾病的客户犬（38只为B1期，13只为B2期，8只为C/D期）接受超声心动图检查，28只犬（14只为B1期，10只为B2期，4只为C/D期）由2名操作人员成像。方法：前瞻性方法比较研究。采用线性方法在长轴和短轴视图（Teichholz、立方体、改良立方体）、单面方法在右胸骨旁和左根尖视图（面积-长度和Simpson椎间盘法）、双面Simpson椎间盘法和实时三平面（RT3D）测量以体重为指标的舒张末期和收缩末期左室容积。结果：RT3P法无偏倚，与RT3D法一致性最高。线性方法对舒张末期容积、收缩末期容积或两者均有显著的偏差和较低的一致性。使用相同的方法从不同的成像视图中得到的体积显示出较差的一致性。RT3P和RT3D方法均表现出较差的操作员间再现性。结论和临床重要性：纳入额外的维度可以改善左室体积量化的偏倚和一致性，但需要RT3P和RT3D的综合临床经验来提高所有操作人员的一致性。

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引用次数: 0

Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-11 DOI: 10.1111/jvim.17284

Megan Lin, Christopher X. Hong, Mark Rishniw, Emma S. Davies, Jonathan H. Wood

Background

Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described.

Hypothesis/Objectives

To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNPE compared to other causes of cervical myelopathy.

Animals

Three hundred seventy-seven client-owned dogs from 2010 to 2022. Cases included 46 HNPE, 192 IVDE (intervertebral disc extrusion), 30 FCEM (fibrocartilaginous embolic myelopathy), 66 CSM (cervical spondylomyelopathy), and 43 neoplasia.

Methods

Retrospective study with record review and bivariate analyses. Dogs with signs of cervical myelopathy and an MRI diagnosis of HNPE, IVDE, FCEM, CSM, or neoplasia were included.

Results

When compared to dogs with other cervical myelopathies, dogs with HNPE were more likely to be older and of lower weight (median age 10 vs 8 years, P < .001; median weight 9.1 vs 20.2 kg, P < .001), be nonambulatory (89% vs 54%, P < .001), have signs of central cord syndrome (35% vs 16%, P = .002), and have nonlateralizing signs of myelopathy (65% vs 48%, P = .029). When compared to dogs with IVDE, dogs with HNPE were more likely to present with lower pain scores (30% vs 15% nonpainful, P = .002), and require mechanical ventilation (4/46 HNPE, 2/192 IVDE; odds ratio [OR] 9.0, 95% confidence interval [CI] 1.6-51.0).

Conclusions and Clinical Importance

Compared to dogs with other cervical myelopathies, dogs with HNPE have differences in clinical characteristics, presentation and likelihood of requiring mechanical ventilation. These differences are important to consider for case management.

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引用次数: 0

Medication compliance by cat owners prescribed treatment for home administration 猫主人的药物依从性规定了家庭管理的治疗方法。

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-11 DOI: 10.1111/jvim.17298

Thomas F. Odom, Christopher B. Riley, Jackie Benschop, Kate E. Hill

Background

Most veterinary literature examining medication compliance has described the phenomenon in dogs. The evidence available regarding factors affecting cat owner medication compliance is limited.

Objectives

Identify and describe factors associated with cat owners' noncompliance with veterinary recommendations for pet medications, as well as client-reported barriers and aids to administering medications prescribed by primary care veterinarians.

Subjects

Cat owners presenting their animals for veterinary examination and treatment.

Methods

A cross-sectional survey of cat owners' compliance with veterinary medication recommendations was performed from January 9, 2019, to July 18, 2020. A convenience sample of owners prescribed medication for their pets by veterinarians during or after elective veterinary examination was recruited to respond to questions regarding medication administration experience and compliance. Follow-up was obtained from owners to determine if the course of medication had been completed. Compliance data were analyzed descriptively, and logistic regression was performed.

Results

Medication noncompliance was recorded for 39% (26/66) of cat owners. A quarter (16/66) reported challenges in administering medication to their pets; the most commonly cited reason was a resistant pet. Oral administration of antibiotics was significantly associated with noncompliance (P = .01). Clients with limited pet ownership experience were less likely to be noncompliant (P = .04).

Conclusions and Clinical Importance

Clients' inability to medicate their cats PO may have implications for clinical outcomes and antimicrobial stewardship. Alternatives to direct PO administration of solid-form medications in cats should be considered. Demonstrating administration techniques to all clients may improve compliance and influence clinical outcome.

背景：大多数检查药物依从性的兽医文献都描述了狗的这种现象。有关影响猫主人服药依从性的因素的证据有限。目的：确定和描述与猫主人不遵守兽医对宠物药物的建议有关的因素，以及客户报告的障碍和辅助管理初级保健兽医开出的药物。研究对象：猫主人带他们的宠物去兽医检查和治疗。方法：从2019年1月9日至2020年7月18日，对猫主人遵守兽医用药建议的情况进行横断面调查。在选择性兽医检查期间或之后，招募了方便的兽医给宠物开药物的主人样本，以回答有关药物管理经验和依从性的问题。对饲主进行随访，以确定是否完成了疗程。对依从性数据进行描述性分析，并进行逻辑回归。结果：39%（26/66）的猫主人有服药不遵医嘱的记录。四分之一（16/66）的人报告了给宠物用药的挑战；最常见的原因是宠物有抵抗力。口服抗生素与不依从性显著相关（P = 0.01）。宠物饲养经验有限的客户不服从的可能性较小（P = .04）。结论和临床重要性：客户无法给猫PO用药可能会影响临床结果和抗菌药物管理。应考虑替代直接给猫PO给药的固体形式药物。向所有患者展示给药技术可以提高依从性并影响临床结果。

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引用次数: 0

Feasibility and complications of videocapsule endoscopy in dogs weighing 7 kg or less 视频胶囊内窥镜检查体重不超过7公斤的狗的可行性和并发症。

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-10 DOI: 10.1111/jvim.17286

Camille St-Jean, Allison Collier, Alex Zur Linden, Alexa Bersenas, Alice Defarges

Background

Videocapsule endoscopy (VCE) is a valuable tool for investigating gastrointestinal (GI) diseases in dogs. Its use is not recommended in dogs ≤4.3 kg, because of risks of GI endoscopic capsule (EC) retention and bowel obstruction.

Objectives

Describe the feasibility and complications of VCE in dogs ≤7 kg.

Animals

Twenty-six client-owned dogs.

Methods

Retrospective study describing the signalment, previous GI imaging, indications, findings, and complications of canine VCE studies submitted to Infiniti Medical between March 2020 and January 2023.

Results

The median weight and age of dogs was 5.6 kg (range, 3-7) and 8.8 years (range, 1-16), respectively. Two capsules were administered endoscopically into the duodenum (1) and stomach (1). Sixteen out of 26 (62%, 95% CI, 40.51-79.70) dogs that underwent VCE had incomplete studies. Of the 24 capsules administered per os, 15 led to incomplete studies (battery died in the stomach (14), EC was vomited (1)). Body weight <5 kg significantly increased the risk of an incomplete study (OR: 3.67, 95% CI, 1.56-inf, P = .0074). Median esophageal, gastric, and small bowel transit time were 5 seconds (range, 1-180), 240 minutes (range, 17-335), and 73.5 minutes (range, 5-168), respectively. All 10 dogs with overt GI bleeding had a possible origin identified with VCE. Complications were limited to vomiting (1/26, 3.85%, 95% CI, 0-11.20).

Conclusions and Clinical Importance

Videocapsule endoscopy is a safe and informative procedure even when performed in dogs as small as 3 kg. However, weighing <5 kg increases the risk of incomplete studies.

背景：视频胶囊内窥镜（VCE）是研究犬胃肠道疾病的一种有价值的工具。由于存在胃肠道内镜胶囊（EC）潴留和肠梗阻的风险，不建议在体重≤4.3 kg的犬只中使用。目的：探讨≤7kg犬VCE的可行性及并发症。动物：26只客户养的狗。方法：回顾性研究，描述2020年3月至2023年1月期间提交给Infiniti Medical的犬VCE研究的信号、既往GI成像、适应症、结果和并发症。结果：狗的中位体重和年龄分别为5.6 kg（范围3-7岁）和8.8岁（范围1-16岁）。两粒胶囊经内窥镜进入十二指肠(1)和胃(1)。26只接受VCE的狗中有16只（62%,95% CI, 40.51-79.70）研究不完整。在每组24颗胶囊中，有15颗导致研究不完整（电池在胃中死亡（14颗），EC呕吐（1颗））。结论和临床重要性：视频胶囊内窥镜检查是一种安全且信息丰富的手术，即使对体重只有3公斤的狗也是如此。然而,重

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引用次数: 0

Comparison of clinical variables and outcome of 2 natural equine herpesvirus myeloencephalopathy outbreaks induced by equine herpesvirus-1 A2254/N752 strain in sport horses 2例由马疱疹病毒-1 A2254/N752株在运动马中引起的天然马疱疹病毒髓性脑病暴发的临床变量和结果比较

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-08 DOI: 10.1111/jvim.17287

María de la Cuesta-Torrado, Ana Velloso Alvarez, José Miguel Cárdenas-Rebollo, Patricia Neira-Egea, Valentina Vitale, Juan Cuervo-Arango

Background

Understanding of equine herpesvirus-1 (EHV-1) myeloencephalopathy (EHM) is complicated by disparities among studies.

Objective

Compare clinical findings and outcome in horses involved in 2 recent EHM outbreaks.

Animals

Twenty-five and 10 horses affected during 2 natural EHM outbreaks were admitted to a veterinary teaching hospital (VTH) in 2021 and 2023, respectively.

Methods

Data collected from the VTH and surveys completed by riders and horse owners were analyzed retrospectively.

Results

No risk factors associated with EHM development showed significant differences between the outbreaks; both outbreaks were caused by A2254/N752 strains. Treatments administered for EHM were not significantly different, whereas the duration was longer in 2021 for flunixin meglumine (P = .01) and dimethyl sulfoxide (P < .001). In 2021, more horses required hospitalization (P = .02), and fatality rate was 32%, whereas in 2023, no patient died. Hospitalization duration was longer in 2021 than in 2023 (P = .06) and 11.7% of horses from 2021 returned to competition within 6 months, whereas 100% in 2023 did (P < .001). Ataxia grade upon admission was equivalent in 2021 and 2023, but factors related to poor prognosis, such as simultaneous development of urinary and vascular complications, occurred in 2021 but not in 2023 (P = .01).

Conclusions and Clinical Importance

Two EHM outbreaks caused by the A2254/N752 strain differed in disease severity. Urinary complications and systemic signs of vasculitis were important clinical variables associated with prognosis. Systemic complications in horses with EHM lead to a worse prognosis.

背景：对马疱疹病毒-1 （EHV-1）髓性脑病（EHM）的认识因研究之间的差异而复杂化。目的：比较最近2例EHM暴发的马的临床表现和结果。动物：在2021年和2023年分别有25匹和10匹马在2次EHM自然暴发中受到感染，被送往兽医教学医院。方法：回顾性分析从VTH收集的数据以及骑手和马主完成的调查。结果：与EHM发展相关的危险因素在疫情之间没有显着差异；两次暴发均由A2254/N752菌株引起。结论和临床意义：A2254/N752菌株引起的两次EHM暴发在疾病严重程度上存在差异。泌尿系统并发症和血管炎的全身体征是影响预后的重要临床变量。EHM马的全身并发症导致预后较差。

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引用次数: 0

Effect of a single rectal fecal microbiota transplantation on clinical severity and fecal microbial communities in dogs with chronic inflammatory enteropathy 单一直肠粪便菌群移植对慢性炎症性肠病犬临床严重程度和粪便微生物群落的影响。

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine

Pub Date : 2025-01-08 DOI: 10.1111/jvim.17264

Jorge Pérez-Accino, Mazdak Salavati, Laura Glendinning, Silke Salavati Schmitz

Background

Fecal microbiota transplantation (FMT) has been advocated as a treatment for chronic enteropathy (CE) in dogs. However, so far only short-term clinical effects have been reported whereas the effect on the microbiota remains unexplored.

Hypothesis/Objectives

Assess if a single FMT enema can lead to clinical improvement in dogs with CE when accompanied by presumed favorable microbiota changes. The effect of glycerol as a cryopreservative when storing FMT preparations also was assessed.

Animals

Seven dogs with CE that received FMTs from 2 healthy donor dogs.

Materials and Methods

Six dogs received a single FMT, 1 dog received 3 consecutive FMTs. Canine chronic enteropathy clinical activity index (CCECAI) and fecal samples were obtained before (Day 0), and 7, 30 and 90 days after FMT. Samples were stored with and without 10% glycerol. Sequencing of microbiota (16S rRNA, Illumina) was performed and compared by accepted analysis pipelines.

Results

Median CCECAI before FMT was 8 (range, 5-14), decreased to a median of 3 (range, 1-12) within 1 week and a median of 1 (range, 0-12) by Day 30 (P < .01), with an average duration of response of approximately 10 weeks. Significant variation in the donors' microbiota composition was observed across different donations. Recipient microbiota composition or diversity did not change over time. Glycerol addition was associated with a difference in microbiota composition (P ≤ .001).

Conclusions and Clinical Importance

A single FMT can be considered an appropriate treatment in dogs with CE, but consistent microbiota changes were not observed.

背景：粪便微生物群移植（FMT）一直被提倡作为狗慢性肠病（CE）的治疗方法。然而，到目前为止，仅报道了短期临床效果，而对微生物群的影响仍未研究。假设/目的：评估单次FMT灌肠是否可以导致CE犬的临床改善，同时假定有利的微生物群变化。甘油作为冷冻保存剂储存FMT制剂时的效果也进行了评估。动物：7只患有CE的狗接受了2只健康供体狗的FMTs。材料与方法：6只犬接受单次FMT， 1只犬连续接受3次FMT。分别于FMT后第0天、第7天、第30天和第90天采集犬慢性肠病临床活动指数（CCECAI）和粪便样本。样品分别在加10%甘油和不加10%甘油的情况下保存。进行微生物群测序（16S rRNA, Illumina），并通过公认的分析管道进行比较。结果：FMT前CCECAI的中位数为8（范围5-14），在1周内降至中位数3（范围1-12），到第30天降至中位数1（范围0-12）(P)结论和临床重要性：单次FMT可被认为是CE犬的适当治疗，但未观察到一致的微生物群变化。

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引用次数: 0