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Influence of acclimatization time on barometric whole-body plethysmography in cats with lower airway disease 适应时间对患有下呼吸道疾病的猫咪全身气压式胸透的影响
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-09-11 DOI: 10.1111/jvim.17147
Lina Hörner-Schmid, Hannah Gareis, Jelena Palić, Bianka Schulz

Background

Barometric whole-body plethysmography (BWBP) is used as a noninvasive method to assess lung function in cats with lower airway disease (LAD). The duration of the acclimatization period in the measuring chamber varies between the studies.

Objectives

To assess the influence of acclimatization time on variables indicative of lung function.

Animals

Twenty-four client-owned cats with LAD and 8 healthy cats.

Methods

In the prospective case-control study for each cat, a 30-minute dataset was collected. Data for the three 10-minute periods were statistically compared.

Results

The variables pause (T1 median: 0.8, range: [0.7-1]; T3: 0.9 [0.8-1.1]; P ≤ .01), peak inspiratory flow (PIF; T1: 84.9 [71.6-112.7]; T3: 75 [63.6-108.3]; P ≤ .001), peak expiratory flow (PEF; T1: 53.2 [41.5-76.6]; T3: 42.5 [34.6-57.8]; P ≤ .01), and a quotient of PEF and expiratory flow at 50% expired volume (PEF/EF50; T1: 1.2 [1.1-1.4]; T3: 1.2 [1.1-1.5]; P ≤ .01) varied significantly between first and third time period in cats with LAD. In healthy cats PIF (T1: 76.4 [66.3-85.2]; T2: 69.5 [58.3-85.2]; P ≤ .01), PEF (T1: 40 [32.8-58.6]; T2: 34.3, [29.8-44.6]; P ≤ .01), and PEF/EF50 (T1: 13.1 [11.6-14.6]; T3: 13.6 [12.4-16.3]; P ≤ .01) changed significantly between first and second time period. Enhanced pause did not change significantly in either group.

Conclusions and Clinical Importance

Acclimatization time has a significant influence on multiple variables in BWBP. Manual correction of the data for tidal breathing flow-volume loop might be necessary.

背景气压全身胸透(BWBP)是一种无创方法,用于评估患有下气道疾病(LAD)的猫的肺功能。方法在前瞻性病例对照研究中,为每只猫收集 30 分钟的数据集。2[41.5-76.6];T3:42.5 [34.6-57.8];P ≤ .01),以及 50%呼气容积时的 PEF 和呼气流量之商(PEF/EF50;T1:1.2 [1.1-1.4];T3:1.2 [1.1-1.5];P ≤ .01)在 LAD 猫的第一和第三个时间段之间变化显著。健康猫的 PIF(T1:76.4 [66.3-85.2];T2:69.5 [58.3-85.2];P ≤ .01)、PEF(T1:40 [32.8-58.6];T2:34.3, [29.8-44.6];P ≤ .01),PEF/EF50(T1:13.1 [11.6-14.6];T3:13.6 [12.4-16.3];P ≤ .01)在第一和第二时间段之间有显著变化。结论和临床意义适应时间对体重测量中的多个变量有重大影响。可能有必要对潮式呼吸流量-容积循环数据进行手动校正。
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引用次数: 0
A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs 一项评估狗急性输血反应发生率和风险因素的前瞻性多中心观察研究。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-09-06 DOI: 10.1111/jvim.17175
Georgina B. F. Hall, Rachael Birkbeck, Benjamin M. Brainard, Fernanda Camacho, Elizabeth B. Davidow, Dana N. LeVine, Andrew Mackin, Taylor Moss, Katherine J. Nash, Giacomo Stanzani, Daria Starybrat, David Q. Stoye, Carolyn Tai, John Thomason, Julie M. Walker, K. Jane Wardrop, Helen Wilson, Virginie A. Wurlod, Karen Humm

Background

Reported incidence of blood transfusion reactions (TR) varies greatly.

Objective

To prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors associated with TRs.

Animals

Dogs (n = 858) administered allogenic blood products (n = 1542) between March and November 2022.

Methods

Prospective, multicenter surveillance study occurring in referral hospitals in the United States, United Kingdom, and Australia recording TRs in dogs administered blood products as defined by the consensus guidelines published by The Association of Veterinary Hematology and Transfusion Medicine in 2021.

Results

The incidence of acute TR was 8.9% (95% CI 7.0-11.1) for packed red blood cells (pRBCs) and 4.5% (95% CI 2.9-6.6) for plasma products. The most frequently reported TRs were febrile nonhemolytic TRs (FNHTR; 4%, 95% CI 2.8-5.5) when administering pRBCs and allergic TRs (3.2%, 95% CI 1.80-5.10) when administering plasma products. A higher dose of pRBC (adjusted odds ratio [aOR] 1.04 [95% CI 1.00-1.08]) was associated with a higher odds of TR. Administration of pRBCs stored for longer than 28 days was associated with higher odds of FNHTR (aOR 4.10 [95% CI 1.58-10.65]) and acute hemolytic TR (AHTR; OR 15.2 [95% CI 3.35-68.70]) when compared with pRBCs stored for 14 days or fewer. Leukoreduction of pRBC was not associated with lower odds of developing a TR (OR 1.47 [95% CI 0.89-2.42]).

Conclusions and Clinical Importance

Clinicians should be mindful of the age and dose of pRBC prescribed to dogs.

背景:据报道,输血反应(TR)的发生率差异很大:报告的输血反应(TR)发生率差异很大:采用共识定义,前瞻性评估接受异体血制品的犬急性输血反应的发生率,并评估与输血反应相关的因素:动物:2022 年 3 月至 11 月期间接受异体血制品治疗的犬(n = 858)(n = 1542):方法:在美国、英国和澳大利亚的转诊医院开展前瞻性多中心监测研究,记录根据兽医血液学和输血医学协会于2021年发布的共识指南所定义的狗血液制品TR:包装红细胞(pRBCs)和血浆产品的急性TR发生率分别为8.9%(95% CI 7.0-11.1)和4.5%(95% CI 2.9-6.6)。在使用 pRBC 时,最常报告的 TR 是发热性非溶血性 TR(FNHTR;4%,95% CI 2.8-5.5),而在使用血浆产品时,最常报告的 TR 是过敏性 TR(3.2%,95% CI 1.80-5.10)。pRBC 剂量越大(调整后的几率比 [aOR] 1.04 [95% CI 1.00-1.08]),发生 TR 的几率越高。与储存 14 天或更短时间的 pRBC 相比,储存超过 28 天的 pRBC 与更高的 FNHTR(aOR 4.10 [95% CI 1.58-10.65])和急性溶血 TR(AHTR;OR 15.2 [95% CI 3.35-68.70])几率相关。pRBC 的白细胞减少与发生 TR 的几率降低无关(OR 1.47 [95% CI 0.89-2.42]):结论和临床意义:临床医生应注意给狗注射 pRBC 的年龄和剂量。
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引用次数: 0
Magnetic resonance imaging features of bilateral multiloculated extraneural ganglion cysts of the occipito-atlanto-axial joint causing hypoglossal nerve paralysis in a dog 导致狗舌下神经麻痹的枕-寰-轴关节双侧多发硬膜外神经节囊肿的磁共振成像特征。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-09-06 DOI: 10.1111/jvim.17192
Minha Ji, Matti Kiupel, Hyungjin Park, Kichang Lee, Hakyoung Yoon

A 14-year-old spayed female Miniature Pinscher presented with tongue curling, dysphagia, hypersalivation, and sublingual gland swelling. Comprehensive evaluation, including neurologic and musculoskeletal examinations, blood work, and urinalysis, revealed no abnormalities other than tongue-related signs. Magnetic resonance imaging (MRI) revealed a multilobed cystic structure in the occipito-atlanto-axial joint, compressing the right hypoglossal canal. The lesion appeared cerebrospinal fluid (CSF)-like on T1-weighted and T2-weighted images, and hyperintense compared with CSF on fluid-attenuated inversion recovery T2-weighted images. The scans suggested mucinous content with enhanced peripheral areas on contrast-enhanced images. Surgical removal and drainage of this cyst were performed, and clinical signs improved markedly. The dorsal cyst was tentatively diagnosed as a ganglion cyst based on histopathologic and imaging findings. Ganglion cysts should be considered in the differential diagnosis for dogs with similar MRI findings and neurologic signs.

一只 14 岁的绝育雌性迷你松狮犬因卷舌、吞咽困难、唾液分泌过多和舌下腺肿胀而就诊。综合评估(包括神经和肌肉骨骼检查、血液检查和尿检)显示,除舌头相关症状外,没有其他异常。磁共振成像(MRI)显示,枕-跖-轴关节处有一个多叶囊性结构,压迫右侧舌下管。病变在T1加权和T2加权图像上呈脑脊液(CSF)样,在液体增强反转恢复T2加权图像上与CSF相比呈高强度。扫描结果显示,在对比度增强图像上,粘液内容物的周边区域增强。对该囊肿进行了手术切除和引流,临床症状明显改善。根据组织病理学和影像学检查结果,背侧囊肿被初步诊断为神经节囊肿。对于有类似核磁共振成像检查结果和神经症状的犬,神经节囊肿应在鉴别诊断中予以考虑。
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引用次数: 0
Urinary iodine clearance after iodinated contrast administration to healthy cats 健康猫使用碘造影剂后的尿碘清除率。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-09-04 DOI: 10.1111/jvim.17172
Gabriella Allegrini, Valerie J. Poirier, Julia G. Pezzali, Hughes H. Beaufrère, Anna K. Shoveller, Matthew A. Kopke, Janet Beeler-Marfisi

Background

Exogenous iodine interferes with the uptake of radioactive iodine (131I) by the thyroid gland. This has potential implications for the treatment of cats with hyperthyroidism that have recently undergone computed tomography (CT) with IV administration of iodinated contrast medium (ICM).

Hypothesis

To determine the time to normalize urinary iodine clearance after administration of ICM. We hypothesized that it would require 4 weeks for urinary iodine concentration (UIC) to decrease to baseline after IV administration of ICM.

Animals

Ten healthy adult neutered male cats.

Methods

All cats were sedated and received Iopamidol at a dose of 2 mL/kg (600 mg/kg). Urinary iodine and creatinine concentrations were measured before administration of Iopamidol and on days 1, 2, 3, 7, 10 and weeks 2 to 6 after administration. The urinary iodine-to-creatinine ratio (UICR) was calculated. Outcome variables were modeled using a linear mixed-effects model.

Results

Urinary iodine concentration increased 37- to 884-fold on Day 1 after ICM injection and returned to baseline during Week 2. Compared with baseline, UIC was significantly increased for Days 1 to 7 (all P < .001); UC was significantly lower for Days 1 to 10 (all P < .03); and UICR was significantly increased from Days 1 to 10 (all P < .001, except Day 10 P = .05).

Conclusions

Urinary clearance of iodine after IV administration of ICM requires 10 days to return to baseline in healthy cats. A 2-week interval between the iodinated contrast study and 131I treatment could be appropriate but needs to be confirmed in hyperthyroid cats.

背景:外源性碘会干扰甲状腺对放射性碘(131I)的吸收。这对治疗最近接受了静脉注射碘造影剂(ICM)的计算机断层扫描(CT)的甲状腺机能亢进症猫有潜在影响:假设:确定使用 ICM 后尿碘清除率恢复正常的时间。我们假设在静脉注射 ICM 后,尿碘浓度 (UIC) 需要 4 周才能降至基线:十只健康的成年绝育公猫:方法:所有猫都被注射镇静剂,并接受 2 mL/kg(600 mg/kg)剂量的碘帕米多。在使用碘帕米多前、使用后第 1、2、3、7、10 天和第 2 至 6 周测量尿碘和肌酐浓度。计算尿碘肌酐比值(UICR)。结果变量采用线性混合效应模型进行建模:结果:注射 ICM 后第 1 天,尿碘浓度增加了 37 至 884 倍,第 2 周恢复到基线水平。与基线相比,第 1 天至第 7 天的尿碘浓度均显著增加(均为 P 结 论):静脉注射 ICM 后,健康猫尿液中碘的清除率需要 10 天才能恢复到基线。碘造影剂检查和 131I 治疗之间间隔 2 周可能是合适的,但需要在甲状腺机能亢进的猫中进行确认。
{"title":"Urinary iodine clearance after iodinated contrast administration to healthy cats","authors":"Gabriella Allegrini,&nbsp;Valerie J. Poirier,&nbsp;Julia G. Pezzali,&nbsp;Hughes H. Beaufrère,&nbsp;Anna K. Shoveller,&nbsp;Matthew A. Kopke,&nbsp;Janet Beeler-Marfisi","doi":"10.1111/jvim.17172","DOIUrl":"10.1111/jvim.17172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Exogenous iodine interferes with the uptake of radioactive iodine (<sup>131</sup>I) by the thyroid gland. This has potential implications for the treatment of cats with hyperthyroidism that have recently undergone computed tomography (CT) with IV administration of iodinated contrast medium (ICM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>To determine the time to normalize urinary iodine clearance after administration of ICM. We hypothesized that it would require 4 weeks for urinary iodine concentration (UIC) to decrease to baseline after IV administration of ICM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Ten healthy adult neutered male cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All cats were sedated and received Iopamidol at a dose of 2 mL/kg (600 mg/kg). Urinary iodine and creatinine concentrations were measured before administration of Iopamidol and on days 1, 2, 3, 7, 10 and weeks 2 to 6 after administration. The urinary iodine-to-creatinine ratio (UICR) was calculated. Outcome variables were modeled using a linear mixed-effects model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Urinary iodine concentration increased 37- to 884-fold on Day 1 after ICM injection and returned to baseline during Week 2. Compared with baseline, UIC was significantly increased for Days 1 to 7 (all <i>P</i> &lt; .001); UC was significantly lower for Days 1 to 10 (all <i>P</i> &lt; .03); and UICR was significantly increased from Days 1 to 10 (all <i>P</i> &lt; .001, except Day 10 <i>P</i> = .05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Urinary clearance of iodine after IV administration of ICM requires 10 days to return to baseline in healthy cats. A 2-week interval between the iodinated contrast study and <sup>131</sup>I treatment could be appropriate but needs to be confirmed in hyperthyroid cats.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous administration of quinidine and metoprolol for treatment of atrial fibrillation in 2 neonatal foals 静脉注射奎尼丁和美托洛尔治疗两只新生马驹的心房颤动。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-08-30 DOI: 10.1111/jvim.17164
Laurence Leduc, Michelle Abraham, JoAnn Slack

Atrial fibrillation (AF) is a rarely reported arrhythmia in otherwise healthy newborn foals, with a single case of cardioversion using procainamide administration described in the literature. Two neonatal Thoroughbred colts were presented to an equine hospital because of an irregularly irregular tachyarrhythmia and poor latching when trying to nurse. History, physical examination, and initial diagnostic testing including ECG and echocardiography confirmed AF without structural heart disease. The 1st foal converted into normal sinus rhythm after treatment with IV metoprolol and quinidine. The 2nd foal converted to normal sinus rhythm after a single IV dose of metoprolol, intended for rate control. Demeanor and nursing behavior improved markedly after conversion. The 2 foals had normal heart rates and sinus rhythm that persisted for 6 weeks until euthanasia in the 1st foal and for 2 years in the 2nd foal. Rate control and cardioversion should be considered as a treatment for persistent lone AF in neonatal foals.

对于健康的新生马驹来说,心房颤动(AF)是一种极少见的心律失常,文献中仅描述过一例使用普鲁卡因胺进行心脏复律的病例。两匹刚出生的纯血马驹因不规则的快速性心律失常和吃奶时咬合不良而被送往一家马科医院。通过询问病史、体格检查以及包括心电图和超声心动图在内的初步诊断测试,证实小马驹患有房颤,但无结构性心脏病。第 1 匹小马在接受美托洛尔和奎尼丁静脉注射治疗后转为正常窦性心律。第二匹小马驹在静脉注射一剂用于控制心率的美托洛尔后转为正常窦性心律。转为窦性心律后,举止和哺乳行为明显改善。两匹小马驹的心率和窦性心律均正常,第一匹小马驹持续了 6 周直至安乐死,第二匹小马驹持续了 2 年。在治疗新生马驹的持续性单独房颤时,应考虑控制心率和心脏复律。
{"title":"Intravenous administration of quinidine and metoprolol for treatment of atrial fibrillation in 2 neonatal foals","authors":"Laurence Leduc,&nbsp;Michelle Abraham,&nbsp;JoAnn Slack","doi":"10.1111/jvim.17164","DOIUrl":"10.1111/jvim.17164","url":null,"abstract":"<p>Atrial fibrillation (AF) is a rarely reported arrhythmia in otherwise healthy newborn foals, with a single case of cardioversion using procainamide administration described in the literature. Two neonatal Thoroughbred colts were presented to an equine hospital because of an irregularly irregular tachyarrhythmia and poor latching when trying to nurse. History, physical examination, and initial diagnostic testing including ECG and echocardiography confirmed AF without structural heart disease. The 1st foal converted into normal sinus rhythm after treatment with IV metoprolol and quinidine. The 2nd foal converted to normal sinus rhythm after a single IV dose of metoprolol, intended for rate control. Demeanor and nursing behavior improved markedly after conversion. The 2 foals had normal heart rates and sinus rhythm that persisted for 6 weeks until euthanasia in the 1st foal and for 2 years in the 2nd foal. Rate control and cardioversion should be considered as a treatment for persistent lone AF in neonatal foals.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of the circulating markers of the renin-angiotensin-aldosterone system in telmisartan- or enalapril-treated dogs with proteinuric chronic kidney disease 经替米沙坦或依那普利治疗的蛋白尿型慢性肾病狗体内肾素-血管紧张素-醛固酮系统循环标志物的特征。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-08-29 DOI: 10.1111/jvim.17186
Joanna E. Murdoch, Bianca N. Lourenço, Roy D. Berghaus, Marisa K. Ames, Hillary K. Hammond, Amanda E. Coleman

Background

Effects of the renin-angiotensin-aldosterone system (RAAS) inhibitors enalapril and telmisartan on circulating RAAS in dogs with proteinuric chronic kidney disease (pCKD) are undescribed.

Objectives

To characterize the RAAS in untreated dogs with pCKD compared to healthy, life-stage- and sex-matched controls, and in dogs with pCKD after 30 days of treatment with enalapril or telmisartan.

Animals

Dogs with pCKD (n = 36) and healthy controls (n = 20).

Methods

Retrospective study of banked samples and previously collected data. Day 0 serum equilibrium concentrations of angiotensin I, II, III, IV, 1-5, and 1-7, and aldosterone, and urinary aldosterone-to-creatinine ratio (UACR) from pCKD dogs were compared to values on day 30 of treatment with enalapril (0.5 mg/kg PO q12) or telmisartan (1 mg/kg PO q24h) and to those of healthy dogs. Data were analyzed using linear mixed models.

Results

Compared with healthy dogs, pCKD dogs had significantly higher Ang I, III, 1-5, and 1-7 concentrations, and UACR. Relative to pretreatment values, day 30 Ang II concentrations were significantly increased and decreased in telmisartan- and enalapril-treated pCKD dogs, respectively (both P < .001). Mean (95% confidence interval) percentage change from pretreatment value in serum Ang 1-7 concentration was significantly greater in telmisartan- (753% [489%-1134%]) versus enalapril-treated (149% [69%-268%]) dogs (P < .001). Serum aldosterone decreased with treatment (P = .02 for enalapril, P < .001 for telmisartan), with no difference between groups at day 30.

Conclusions and Clinical Importance

Circulating RAAS activity is higher in dogs with pCKD. Compared with enalapril, treatment with telmisartan caused significantly greater increases in the presumed beneficial peptide Ang 1-7.

背景:肾素-血管紧张素-醛固酮系统(RAAS)抑制剂依那普利和替米沙坦对蛋白尿性慢性肾脏病(pCKD)犬体内循环RAAS的影响尚不清楚:目的:与健康、生命阶段和性别匹配的对照组相比,研究未经治疗的 pCKD 狗的 RAAS 特征,以及使用依那普利或替米沙坦治疗 30 天后的 pCKD 狗的 RAAS 特征:动物:患有 pCKD 的狗(36 只)和健康对照组(20 只):方法:对银行样本和以前收集的数据进行回顾性研究。将pCKD犬第0天血清中血管紧张素I、II、III、IV、1-5和1-7以及醛固酮的平衡浓度和尿中醛固酮与肌酐的比率(UACR)与依那普利(0.5 mg/kg PO q12)或替米沙坦(1 mg/kg PO q24h)治疗第30天的值以及健康犬的值进行比较。数据采用线性混合模型进行分析:结果:与健康狗相比,pCKD 狗的血管紧张素 I、III、1-5 和 1-7 浓度以及 UACR 明显更高。与治疗前的值相比,替米沙坦和依那普利治疗的 pCKD 犬在第 30 天的 Ang II 浓度分别明显升高和降低(均为 P 结论和临床重要性:pCKD犬的循环RAAS活性较高。与依那普利相比,使用替米沙坦治疗时,假定的有益肽Ang 1-7的增加幅度更大。
{"title":"Characterization of the circulating markers of the renin-angiotensin-aldosterone system in telmisartan- or enalapril-treated dogs with proteinuric chronic kidney disease","authors":"Joanna E. Murdoch,&nbsp;Bianca N. Lourenço,&nbsp;Roy D. Berghaus,&nbsp;Marisa K. Ames,&nbsp;Hillary K. Hammond,&nbsp;Amanda E. Coleman","doi":"10.1111/jvim.17186","DOIUrl":"10.1111/jvim.17186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Effects of the renin-angiotensin-aldosterone system (RAAS) inhibitors enalapril and telmisartan on circulating RAAS in dogs with proteinuric chronic kidney disease (pCKD) are undescribed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To characterize the RAAS in untreated dogs with pCKD compared to healthy, life-stage- and sex-matched controls, and in dogs with pCKD after 30 days of treatment with enalapril or telmisartan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Dogs with pCKD (n = 36) and healthy controls (n = 20).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective study of banked samples and previously collected data. Day 0 serum equilibrium concentrations of angiotensin I, II, III, IV, 1-5, and 1-7, and aldosterone, and urinary aldosterone-to-creatinine ratio (UACR) from pCKD dogs were compared to values on day 30 of treatment with enalapril (0.5 mg/kg PO q12) or telmisartan (1 mg/kg PO q24h) and to those of healthy dogs. Data were analyzed using linear mixed models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with healthy dogs, pCKD dogs had significantly higher Ang I, III, 1-5, and 1-7 concentrations, and UACR. Relative to pretreatment values, day 30 Ang II concentrations were significantly increased and decreased in telmisartan- and enalapril-treated pCKD dogs, respectively (both <i>P</i> &lt; .001). Mean (95% confidence interval) percentage change from pretreatment value in serum Ang 1-7 concentration was significantly greater in telmisartan- (753% [489%-1134%]) versus enalapril-treated (149% [69%-268%]) dogs (<i>P</i> &lt; .001). Serum aldosterone decreased with treatment (<i>P</i> = .02 for enalapril, <i>P</i> &lt; .001 for telmisartan), with no difference between groups at day 30.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Circulating RAAS activity is higher in dogs with pCKD. Compared with enalapril, treatment with telmisartan caused significantly greater increases in the presumed beneficial peptide Ang 1-7.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute leptospirosis in horses: A retrospective study of 11 cases (2015-2023) 马的急性钩端螺旋体病:11例病例的回顾性研究(2015-2023年)。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-08-28 DOI: 10.1111/jvim.17184
Lynette Ramsay, Christina Eberhardt, Angelika Schoster

Background

Reports of leptospirosis in horses are limited.

Objectives

To describe the clinical and diagnostic findings of acute systemic leptospirosis in horses.

Animals

Eleven client-owned horses presented to an equine hospital because of acute onset of disease between 2015 and 2023.

Methods

Retrospective case series. Horses diagnosed with leptospirosis by 1 or more of urine PCR, serologic microscopic agglutination test (MAT), and histopathology.

Results

Common clinical signs included lethargy (10), anorexia (10), fever (9), tachypnea (9), abnormal lung sounds (9), and epistaxis (6). Acute kidney injury was present in all cases. Evidence of pulmonary hemorrhage and liver disease was found in 8 (73%) and 6 (55%) horses, respectively. In 6 (55%) horses, kidneys, lungs, and liver were affected. Urine quantitative polymerase chain reaction for detection of pathogenic Leptospira spp. was positive in 6 (55%) cases. On serology Leptospira interrogans serovar Australis, Autumnalis, and Bratislava accounted for 86% of all titers ≥1 : 800. Overall case fatality rate was 4/11 (36%). Main findings on necropsy were tubular necrosis, interstitial nephritis, hemorrhage in the alveoli, pulmonary edema, periportal hepatitis and necrosis, cholestasis, and cholangitis.

Conclusions and Clinical Importance

Leptospirosis should be considered as a differential diagnosis in horses with evidence of acute systemic inflammation and acute renal injury, epistaxis, or hepatic disease. For increased likelihood of identifying positive cases, both MAT serology and urine PCR should be performed.

背景:有关马患钩端螺旋体病的报道有限:描述马匹急性全身性钩端螺旋体病的临床和诊断结果:方法:回顾性病例系列:回顾性病例系列。通过尿液PCR、血清学显微凝集试验(MAT)和组织病理学中的一种或多种方法确诊为钩端螺旋体病的马匹:常见的临床症状包括嗜睡(10 头)、厌食(10 头)、发热(9 头)、呼吸急促(9 头)、肺部听诊异常(9 头)和鼻衄(6 头)。所有病例均出现急性肾损伤。8匹马(73%)和6匹马(55%)分别出现肺出血和肝病。6匹马(55%)的肾脏、肺部和肝脏都受到了影响。6匹马(55%)的尿液定量聚合酶链反应检测病原性钩端螺旋体呈阳性。在所有滴度≥1:800的病例中,86%的病例血清学检测结果为钩端螺旋体血清澳州种、秋季种和布拉迪斯拉发种。总病死率为 4/11(36%)。尸体解剖的主要结果是肾小管坏死、间质性肾炎、肺泡出血、肺水肿、肝周炎和坏死、胆汁淤积和胆管炎:对于有急性全身炎症和急性肾损伤、鼻衄或肝病证据的马匹,钩端螺旋体病应被视为鉴别诊断。为了提高确定阳性病例的可能性,应同时进行MAT血清学检查和尿液PCR检查。
{"title":"Acute leptospirosis in horses: A retrospective study of 11 cases (2015-2023)","authors":"Lynette Ramsay,&nbsp;Christina Eberhardt,&nbsp;Angelika Schoster","doi":"10.1111/jvim.17184","DOIUrl":"10.1111/jvim.17184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Reports of leptospirosis in horses are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To describe the clinical and diagnostic findings of acute systemic leptospirosis in horses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Eleven client-owned horses presented to an equine hospital because of acute onset of disease between 2015 and 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective case series. Horses diagnosed with leptospirosis by 1 or more of urine PCR, serologic microscopic agglutination test (MAT), and histopathology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Common clinical signs included lethargy (10), anorexia (10), fever (9), tachypnea (9), abnormal lung sounds (9), and epistaxis (6). Acute kidney injury was present in all cases. Evidence of pulmonary hemorrhage and liver disease was found in 8 (73%) and 6 (55%) horses, respectively. In 6 (55%) horses, kidneys, lungs, and liver were affected. Urine quantitative polymerase chain reaction for detection of pathogenic <i>Leptospira</i> spp. was positive in 6 (55%) cases. On serology <i>Leptospira interrogans</i> serovar Australis, Autumnalis, and Bratislava accounted for 86% of all titers ≥1 : 800. Overall case fatality rate was 4/11 (36%). Main findings on necropsy were tubular necrosis, interstitial nephritis, hemorrhage in the alveoli, pulmonary edema, periportal hepatitis and necrosis, cholestasis, and cholangitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Leptospirosis should be considered as a differential diagnosis in horses with evidence of acute systemic inflammation and acute renal injury, epistaxis, or hepatic disease. For increased likelihood of identifying positive cases, both MAT serology and urine PCR should be performed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urothelial carcinoma associated with a long-term indwelling cystostomy component of a subcutaneous ureteral bypass device in a domestic shorthair cat 家养短毛猫与皮下输尿管旁路装置的长期留置膀胱造口组件相关的尿道癌。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-08-28 DOI: 10.1111/jvim.17183
Samantha Lackeyram-Owen, Erin Gibson, Jennifer Reetz, Taylor Chan, Charles-Antoine Assenmacher, Dana L. Clarke

Urothelial carcinoma (UC) occurs uncommonly in cats and no association has previously been observed with long-term indwelling urinary implants. An 18-year-old male castrated domestic shorthair cat initially was presented for hematuria, leading to the diagnosis of a right-sided ureterolithiasis and severe pyelectasia on ultrasound examination, prompting right-sided subcutaneous ureteral bypass (SUB) device placement. The cat subsequently had intermittent hematuria and dysuria, without ultrasonographic abnormality of the bladder or positive urine culture. Thirteen months later the patient developed refractory lower urinary tract signs, azotemia, a proliferative mass in the region of the cystostomy tube component of the SUB device and evidence of left ureteral obstruction. Cystostomy tube revision and left-sided SUB device placement were performed, as well as a partial cystectomy for removal of the mass. Upon histopathology, the mass was diagnosed as a UC. To our knowledge, UC associated with a long-term indwelling cystostomy catheter component of a SUB device has not been reported in veterinary medicine.

猫患上尿道上皮癌(UC)的情况并不常见,以前也没有观察到UC与长期留置的尿路植入物有关。一只 18 岁的雄性阉割家养短毛猫最初因血尿就诊,超声波检查诊断为右侧输尿管结石和严重的泌尿系统梗阻,因此需要植入右侧皮下输尿管旁路(SUB)装置。随后,该猫出现间歇性血尿和排尿困难,但膀胱超声检查未见异常,尿培养也未呈阳性。13 个月后,患者出现了难治性下尿路症状、氮质血症、SUB 装置的膀胱造口管部位出现增生性肿块以及左侧输尿管梗阻的迹象。患者接受了膀胱造口管修补术和左侧 SUB 装置置入术,并进行了部分膀胱切除术以切除肿块。经组织病理学检查,肿块被诊断为 UC。据我们所知,与 SUB 装置中长期留置的膀胱造口导管组件相关的 UC 在兽医学中还没有报道过。
{"title":"Urothelial carcinoma associated with a long-term indwelling cystostomy component of a subcutaneous ureteral bypass device in a domestic shorthair cat","authors":"Samantha Lackeyram-Owen,&nbsp;Erin Gibson,&nbsp;Jennifer Reetz,&nbsp;Taylor Chan,&nbsp;Charles-Antoine Assenmacher,&nbsp;Dana L. Clarke","doi":"10.1111/jvim.17183","DOIUrl":"10.1111/jvim.17183","url":null,"abstract":"<p>Urothelial carcinoma (UC) occurs uncommonly in cats and no association has previously been observed with long-term indwelling urinary implants. An 18-year-old male castrated domestic shorthair cat initially was presented for hematuria, leading to the diagnosis of a right-sided ureterolithiasis and severe pyelectasia on ultrasound examination, prompting right-sided subcutaneous ureteral bypass (SUB) device placement. The cat subsequently had intermittent hematuria and dysuria, without ultrasonographic abnormality of the bladder or positive urine culture. Thirteen months later the patient developed refractory lower urinary tract signs, azotemia, a proliferative mass in the region of the cystostomy tube component of the SUB device and evidence of left ureteral obstruction. Cystostomy tube revision and left-sided SUB device placement were performed, as well as a partial cystectomy for removal of the mass. Upon histopathology, the mass was diagnosed as a UC. To our knowledge, UC associated with a long-term indwelling cystostomy catheter component of a SUB device has not been reported in veterinary medicine.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Einthoven's triangle adapted for horses: Proposal for the Delta configuration 适用于马匹的 Einthoven 三角形:关于三角洲配置的建议。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-08-28 DOI: 10.1111/jvim.17179
Ellen Paulussen, Glenn Van Steenkiste, Ben J. M. Hermans, Annelies Decloedt, Gunther van Loon, Tammo Delhaas

Background

Reliable ECGs are crucial for diagnosing arrhythmias, yet a lack of standardization impedes arrhythmia diagnosis and treatment in horses.

Objectives

To objectively determine an optimal position of Einthoven's triangle for ECG recordings in horses at rest, which can form the basis for standardized ECG recording and improve diagnosis and treatment of arrhythmias.

Animals

The study involved 72 healthy, warmblood horses aged between 3 and 20 years.

Methods

In view of future 12-lead studies and vectorcardiography, requiring an orthogonal system, Einthoven's triangle was positioned around the heart, in the transverse plane. Therefore, 11 electrodes were placed encircling the thorax behind the olecranon, to construct triangles with a horizontal base. Electrocardiogram recordings from different triangles were analyzed. Signal processing involved filtering, R peak detection, and median complex generation. Principal component analysis (PCA) and Euclidean distance measures were employed for data analysis.

Results

The left mid-thoracic and ventral regions had high PCA scores, indicating high information content. Base-down triangles exhibited higher summed Euclidean distances, contributing to enhanced diagnostic capabilities. A base-down triangle, called “Delta (Δ) configuration” emerged as most informative, while meeting all criteria.

Conclusions and Clinical Importance

The base-down “Delta configuration” is the optimal Einthoven's triangle adapted for horses, providing large amplitudes and potential to provide basic insights into the mechanisms and origins of cardiac arrhythmias. Because the Delta configuration is positioned in the transverse plane, it forms the ideal basis for 12-lead ECG recordings that provide vectorcardiograms in an orthogonal coordinate system. Standardizing electrode positioning could improve ECG data comparability in equine cardiology.

背景:可靠的心电图是诊断心律失常的关键:可靠的心电图是诊断心律失常的关键,但标准化的缺乏阻碍了马匹心律失常的诊断和治疗:客观确定马匹在静息状态下进行心电图记录时 Einthoven 三角区的最佳位置,从而为标准化心电图记录奠定基础,改善心律失常的诊断和治疗:研究涉及 72 匹健康的温血马,年龄在 3 至 20 岁之间:鉴于未来的 12 导联研究和矢量心电图需要一个正交系统,Einthoven 三角形被放置在心脏周围的横向平面上。因此,11 个电极被放置在肩胛骨后环绕胸部的位置,以构建具有水平基底的三角形。对不同三角形的心电图记录进行分析。信号处理包括滤波、R 峰检测和中位复数生成。数据分析采用了主成分分析法(PCA)和欧氏距离测量法:结果:左胸中部和腹侧区域的 PCA 分数较高,表明信息含量较高。基底向下三角形的欧氏距离总和较高,有助于提高诊断能力。被称为 "Delta (Δ) 构型 "的基底向下三角形信息量最大,同时符合所有标准:结论和临床意义:基底向下的 "Delta构型 "是适用于马匹的最佳Einthoven's 三角形,可提供大振幅,并有可能为了解心律失常的机制和起源提供基本信息。由于三角构型位于横向平面,因此是 12 导联心电图记录的理想基础,可在正交坐标系中提供矢量心电图。电极定位标准化可提高马心脏病学中心电图数据的可比性。
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引用次数: 0
Mydriasis associated with ischemic cerebrovascular infarct affecting the ipsilateral cerebellar interposital nucleus in 2 dogs 两只狗的同侧小脑眶间核缺血性脑血管梗塞引起的眼球模糊。
IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES Pub Date : 2024-08-28 DOI: 10.1111/jvim.17176
Cecilia-Gabriella Danciu, Joe Fenn, Elsa Beltran

A 10-year-old male neutered crossbreed dog and an 8-year-old female neutered greyhound presented after peracute onset of cerebellar dysfunction. The crossbreed dog had anisocoria with the left pupil being mydriatic, spontaneous conjugate rotatory nystagmus with fast phase to the left and delayed postural reactions on the left side. The greyhound had anisocoria with the left pupil being mydriatic, right positional ventral strabismus, absent menace response in the left eye and postural reaction deficits on the left side. For both dogs, the neuroanatomical localization was left cerebellum with paradoxical vestibular syndrome. Magnetic resonance imaging identified a left cerebellar ischemic territorial infarct of the rostral cerebellar artery, involving the region of the left interposital nucleus. Both dogs were given supportive care and at 2-week follow-up the anisocoria had resolved. Anisocoria with mydriasis can be a clinical sign in dogs with naturally-occurring cerebellar ischemic infarcts in the region of the ipsilateral interposital nucleus.

一只 10 岁的雄性阉割杂交犬和一只 8 岁的雌性阉割灰猎犬在小脑功能障碍急性发作后就诊。这只杂交犬有左侧瞳孔近视、自发性共轭旋转性眼球震颤并向左侧快速移动,左侧姿势反应迟钝。灰猎犬左眼瞳孔散大,右侧位置性腹侧斜视,左眼无威胁反应,左侧姿势反应障碍。两只狗的神经解剖定位均为左侧小脑伴矛盾性前庭综合征。磁共振成像检查发现,左侧小脑喙小脑动脉缺血性区域梗死,涉及左侧眶间核区域。两只狗都接受了支持性治疗,在两周的随访中,失视症状均已缓解。同侧小脑眶间核区域自然发生的小脑缺血性梗死可导致犬出现伴有瞳孔散大的失视临床症状。
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引用次数: 0
期刊
Journal of Veterinary Internal Medicine
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