Journal of Veterinary Internal Medicine最新文献

S. A. Jablonski, S. B. Shropshire, V. E. Watson, et al., “Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial,” Journal of Veterinary Internal Medicine 39, no. 4 (2025): e70147, https://doi.org/10.1111/jvim.70147.

In the above-mentioned article, in Section 4 Discussion, second paragraph, lines five, six, and seven the word “dogs” should be replaced with “humans.” The sentences should be as follows.

“In humans with IBD, the prevalence of baseline hypovitaminosis D has been reported to range from 35% to 100% in humans with CD, and 45% to 50% in humans with UC [27]. Subsequently, several clinical trials have been performed evaluating various vitamin D treatments in humans with both CD and UC, some of which have shown positive benefits such as improvements in clinical activity index scores, reductions in inflammatory markers [13], and reduced utilizations of healthcare [14]. An additional placebo-controlled, randomized, clinical trial of 94 humans with CD found that the clinical relapse rate was lower in humans treated with cholecalciferol compared to humans treated with placebo, though the difference was not statistically different (p = 0.06) [28].”

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LHX3 mutation in dogs is associated with combined pituitary hormone deficiency. However, ACTH secretion is usually preserved. A 9-week-old female White Swiss Shepherd dog presented with growth retardation and was diagnosed with pituitary dwarfism due to LHX3 mutation. In the 2 years after diagnosis, the dog developed persistent lymphocytosis and eosinophilia. Endogenous ACTH measurement, ACTH stimulation test, and CRH stimulation test confirmed pituitary hypocortisolism. The dog was administered physiological doses of prednisolone, with improvement of activity levels. These findings are similar to scarce human reports and suggest that corticotrope function might decline over time in dogs with LHX3 mutations. Awareness and screening for ACTH deficiency in dwarf dogs is important in light of compatible clinical signs and laboratory abnormalities, as treatment with glucocorticoids improves the quality of life of these dogs.

We report on the identification of bovine bosavirus associated with a post-transfusion hepatopathy in a 4-month-old Holstein bull calf that was referred for enteritis and fever of unknown origin. Next-generation sequencing (NGS) of post-transfusion blood and liver tissue from the calf, alongside NGS of plasma from the donor, identified a bovine bosavirus. This virus has been previously identified in bovine calf serum, calves with mucosal disease, and the blood of bison but was of uncertain clinical importance. These findings have biosecurity implications for clinicians using bovine whole blood or plasma therapeutically and suggest the need for pre- or postharvest donor screening or biologic processing to prevent infection of recipients. The calf made a full clinical recovery.

An 11-year-old male castrated Boston Terrier dog presented with acute onset lethargy and vomiting. On examination, the dog was febrile, tachycardic, and thought to have generalized abdominal pain. Abdominal ultrasonography identified a fluid-filled hepatic mass with suspected surrounding steatitis. Cytology from the hepatic mass indicated septic neutrophilic inflammation with extracellular and intracellular curved to spiral small bacterial organisms consistent with Campylobacter spp. The cytology results prompted appropriate isolation techniques composed of microaerophilic culture methods, which resulted in isolation of Campylobacter upsaliensis. Anaerobic and aerobic cultures also were performed and yielded no growth. Because of prognosis, the owner elected euthanasia, and necropsy identified a hepatocellular carcinoma as the underlying lesion for the abscessed hepatic mass.

A 3.5-year-old castrated male domestic medium hair cat was evaluated for dry cough and labored breathing. A cranial mediastinal mass was seen on thoracic radiographs. On computed tomography, the mass displaced the cranial vena cava and dorsally displaced and compressed the intrathoracic trachea. The patient was taken to surgery for attempted mass removal. Intraoperatively, the mass was adhered to the cranial vena cava, aortic arch, left subclavian artery, and had partially engulfed the brachiocephalic trunk. The cat was euthanized and on necropsy the mass was found to invade the lumen of the vena cava and the tracheal lumen. An Aspergillus lentulus fungal granuloma was diagnosed histologically and by fungal culture and PCR. We highlight the difficulty in determining the extent of invasion with invasive aspergillosis and provide evidence that invasive aspergillosis can occur in otherwise healthy, young cats with no concurrent immunosuppressive treatments or comorbidities.