Pub Date : 2025-01-23DOI: 10.1038/s44286-025-00174-1
When glucose is used as the main carbon source in microbial cultures, its uptake rate directly influences the overall metabolic flux. This study presents genetic circuits that can detect the glucose uptake rate and dynamically regulate the associated metabolic fluxes and the synthesis of desired products.
{"title":"Biosensors responsive to glucose uptake rates can dynamically regulate metabolic flux","authors":"","doi":"10.1038/s44286-025-00174-1","DOIUrl":"10.1038/s44286-025-00174-1","url":null,"abstract":"When glucose is used as the main carbon source in microbial cultures, its uptake rate directly influences the overall metabolic flux. This study presents genetic circuits that can detect the glucose uptake rate and dynamically regulate the associated metabolic fluxes and the synthesis of desired products.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"34-35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1038/s44286-024-00170-x
John R. Kitchin, Victor Alves, Carl D. Laird
Differentiable programming underpins the foundations of machine learning, and enables new approaches to solving chemical engineering problems. This Comment discusses the opportunities and challenges in education and preparing the workforce to leverage these tools. Integration of these skills with domain knowledge can have a substantial impact on the future of chemical engineering.
{"title":"Beyond the fourth paradigm of modeling in chemical engineering","authors":"John R. Kitchin, Victor Alves, Carl D. Laird","doi":"10.1038/s44286-024-00170-x","DOIUrl":"10.1038/s44286-024-00170-x","url":null,"abstract":"Differentiable programming underpins the foundations of machine learning, and enables new approaches to solving chemical engineering problems. This Comment discusses the opportunities and challenges in education and preparing the workforce to leverage these tools. Integration of these skills with domain knowledge can have a substantial impact on the future of chemical engineering.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00170-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1038/s44286-024-00160-z
Ahmad Elgazzar, Haotian Wang
Electrolyzers have been refined to reach a minimized gap between the electrodes, exemplified by the ''zero gap'' membrane electrode assembly in water electrolyzers. This Comment discusses the porous solid electrolyte reactor, where this gap is re-opened to fully leverage ionic transport for broader applications beyond molecular transformations in electrolysis.
{"title":"Beyond molecular transformations in electrochemical porous solid electrolyte reactors","authors":"Ahmad Elgazzar, Haotian Wang","doi":"10.1038/s44286-024-00160-z","DOIUrl":"10.1038/s44286-024-00160-z","url":null,"abstract":"Electrolyzers have been refined to reach a minimized gap between the electrodes, exemplified by the ''zero gap'' membrane electrode assembly in water electrolyzers. This Comment discusses the porous solid electrolyte reactor, where this gap is re-opened to fully leverage ionic transport for broader applications beyond molecular transformations in electrolysis.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00160-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1038/s44286-024-00162-x
Yizhen Chen, Jiankang Zhao, Xiao Zhao, Di Wu, Nan Zhang, Junjie Du, Jie Zeng, Xu Li, Miquel Salmeron, Jingyue Liu, Bruce C. Gates
Supported noble metal cluster catalysts provide the advantages of high atom efficiency and size-dependent properties, but their stabilization remains a major challenge for industrial applications. Now we report an approach for the stabilization of nuclearity-controlled platinum nanoclusters with a typical diameter of ~0.7 nm (Pt7−14) confined on CeOx nanoislands on a porous silica support. The clusters were synthesized by the reduction of platinum single atoms on the islands in H2 at 400 °C. Redox cycles led to cluster formation and breakup at hundreds of degrees Celsius, with platinum remaining confined to the respective islands. The clusters maintained their nuclearity and were resistant to sintering in H2 at temperatures of ≤600 °C and atmospheric pressure. Experimental catalyst performance data bolstered by computational results demonstrate that these platinum clusters are more active than mononuclear platinum, also exhibiting higher steady-state activity than larger and smaller platinum clusters for ethylene hydrogenation. Platinum nanoclusters comprising about ten atoms each made by reducing isolated platinum cations in CeOx nests isolated on high-area silica are demonstrated. Two forms of platinum were reversibly interconverted by oxidation/reduction, remaining stably confined to the nests even under severe conditions, in H2 at 600 °C and under atmospheric pressure.
支撑贵金属簇催化剂具有高原子效率和尺寸相关特性的优势，但其稳定化仍是工业应用的一大挑战。现在，我们报告了一种稳定铂纳米簇的方法，铂纳米簇的典型直径约为 0.7 纳米（Pt7-14），铂纳米簇被限制在多孔二氧化硅载体上的 CeOx 纳米岛上。铂簇是在 400 °C 的 H2 中通过还原铂岛上的铂单原子而合成的。氧化还原循环导致铂簇在数百摄氏度的高温下形成和破裂，铂仍被限制在各自的原子岛上。铂簇保持了其核性，在温度≤600 °C、大气压力下的 H2 中不易烧结。实验催化剂性能数据和计算结果表明，这些铂簇比单核铂更活跃，在乙烯加氢过程中也比较大和较小的铂簇表现出更高的稳态活性。通过还原分离在高面积二氧化硅上的 CeOx 嵌套中的分离铂阳离子，展示了由每个约十个原子组成的纳米铂簇。通过氧化/还原，两种形式的铂发生了可逆的相互转化，即使在苛刻的条件下，在 600 °C 的 H2 和大气压力下，也能稳定地保留在铂巢中。
{"title":"Stabilizing supported atom-precise low-nuclearity platinum cluster catalysts by nanoscale confinement","authors":"Yizhen Chen, Jiankang Zhao, Xiao Zhao, Di Wu, Nan Zhang, Junjie Du, Jie Zeng, Xu Li, Miquel Salmeron, Jingyue Liu, Bruce C. Gates","doi":"10.1038/s44286-024-00162-x","DOIUrl":"10.1038/s44286-024-00162-x","url":null,"abstract":"Supported noble metal cluster catalysts provide the advantages of high atom efficiency and size-dependent properties, but their stabilization remains a major challenge for industrial applications. Now we report an approach for the stabilization of nuclearity-controlled platinum nanoclusters with a typical diameter of ~0.7 nm (Pt7−14) confined on CeOx nanoislands on a porous silica support. The clusters were synthesized by the reduction of platinum single atoms on the islands in H2 at 400 °C. Redox cycles led to cluster formation and breakup at hundreds of degrees Celsius, with platinum remaining confined to the respective islands. The clusters maintained their nuclearity and were resistant to sintering in H2 at temperatures of ≤600 °C and atmospheric pressure. Experimental catalyst performance data bolstered by computational results demonstrate that these platinum clusters are more active than mononuclear platinum, also exhibiting higher steady-state activity than larger and smaller platinum clusters for ethylene hydrogenation. Platinum nanoclusters comprising about ten atoms each made by reducing isolated platinum cations in CeOx nests isolated on high-area silica are demonstrated. Two forms of platinum were reversibly interconverted by oxidation/reduction, remaining stably confined to the nests even under severe conditions, in H2 at 600 °C and under atmospheric pressure.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"38-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00162-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The rate of glucose import directly affects the maximum possible flux of central carbon metabolism. However, few tools can directly monitor the cellular glucose uptake rate. Here we report the development of a set of programmable bifunctional glucose uptake rate biosensors (GURBs) for real-time monitoring of glucose uptake rate, which enable the dynamic activation and inhibition of glucose uptake and central metabolism in Escherichia coli. These genetic circuits are used to monitor the glucose uptake rates of strains under different culture conditions. Also, feedback-loop control systems are designed to make cells rely on the glucose uptake rate to tune the target metabolic modules, resulting in a substantial increase of the titers of l-tryptophan, riboflavin and d-lactic acid. The glucose-uptake-rate-responsive genetic circuits developed in this study will serve as an effective tool for the dynamic control of glucose uptake and central metabolism. Glucose uptake is the initial step in cellular metabolism, and its uptake rate directly determines the overall metabolic flow. Here the authors develop a set of programmable bifunctional biosensors for real-time monitoring of glucose uptake rates and dynamic dual control of glucose uptake and central metabolism.
{"title":"Monitoring and dynamically controlling glucose uptake rate and central metabolism","authors":"Dongqin Ding, Yaru Zhu, Danyang Bai, Tongxin Wan, Sang Yup Lee, Dawei Zhang","doi":"10.1038/s44286-024-00163-w","DOIUrl":"10.1038/s44286-024-00163-w","url":null,"abstract":"The rate of glucose import directly affects the maximum possible flux of central carbon metabolism. However, few tools can directly monitor the cellular glucose uptake rate. Here we report the development of a set of programmable bifunctional glucose uptake rate biosensors (GURBs) for real-time monitoring of glucose uptake rate, which enable the dynamic activation and inhibition of glucose uptake and central metabolism in Escherichia coli. These genetic circuits are used to monitor the glucose uptake rates of strains under different culture conditions. Also, feedback-loop control systems are designed to make cells rely on the glucose uptake rate to tune the target metabolic modules, resulting in a substantial increase of the titers of l-tryptophan, riboflavin and d-lactic acid. The glucose-uptake-rate-responsive genetic circuits developed in this study will serve as an effective tool for the dynamic control of glucose uptake and central metabolism. Glucose uptake is the initial step in cellular metabolism, and its uptake rate directly determines the overall metabolic flow. Here the authors develop a set of programmable bifunctional biosensors for real-time monitoring of glucose uptake rates and dynamic dual control of glucose uptake and central metabolism.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"50-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00163-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-31DOI: 10.1038/s44286-024-00161-y
David Kitto, Jovan Kamcev
Fundamental transport modeling of bipolar membranes has identified sources of inefficiencies in power-generating applications. These insights can guide the development of improved membranes, ultimately aiding in energy recovery across various electrochemical technologies.
{"title":"Modeling insights to navigate limitations in bipolar membranes","authors":"David Kitto, Jovan Kamcev","doi":"10.1038/s44286-024-00161-y","DOIUrl":"10.1038/s44286-024-00161-y","url":null,"abstract":"Fundamental transport modeling of bipolar membranes has identified sources of inefficiencies in power-generating applications. These insights can guide the development of improved membranes, ultimately aiding in energy recovery across various electrochemical technologies.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"30-31"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-31DOI: 10.1038/s44286-024-00166-7
Mo Qiao
{"title":"A framework for direct CO2 capture from air","authors":"Mo Qiao","doi":"10.1038/s44286-024-00166-7","DOIUrl":"10.1038/s44286-024-00166-7","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"27-27"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-31DOI: 10.1038/s44286-024-00167-6
Alessio Lavino
{"title":"Chemical looping in metabolic nanoreactors","authors":"Alessio Lavino","doi":"10.1038/s44286-024-00167-6","DOIUrl":"10.1038/s44286-024-00167-6","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 2","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-31DOI: 10.1038/s44286-024-00165-8
Considering consumer behavioral norms is important to sustainable design. This Editorial discusses the need to incorporate behavioral patterns into product design and the role that the chemical engineering community can play in fostering a more informed understanding of sustainability among consumers.
{"title":"The human element of process design","authors":"","doi":"10.1038/s44286-024-00165-8","DOIUrl":"10.1038/s44286-024-00165-8","url":null,"abstract":"Considering consumer behavioral norms is important to sustainable design. This Editorial discusses the need to incorporate behavioral patterns into product design and the role that the chemical engineering community can play in fostering a more informed understanding of sustainability among consumers.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"1 12","pages":"788-789"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00165-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-27DOI: 10.1038/s44286-024-00156-9
Degradable poly(β-amino ester) (PAE) polymers can be used as a scalable alternative to microplastics in personal care products and nutrient delivery. This study demonstrates the effectiveness of PAE microparticles in skin exfoliation and nutrient protection, providing a potential eco-friendly solution to reduce microplastic pollution and its associated environmental and health impacts.
{"title":"Sustainable alternatives to microplastics from degradable polymer microparticles","authors":"","doi":"10.1038/s44286-024-00156-9","DOIUrl":"10.1038/s44286-024-00156-9","url":null,"abstract":"Degradable poly(β-amino ester) (PAE) polymers can be used as a scalable alternative to microplastics in personal care products and nutrient delivery. This study demonstrates the effectiveness of PAE microparticles in skin exfoliation and nutrient protection, providing a potential eco-friendly solution to reduce microplastic pollution and its associated environmental and health impacts.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 1","pages":"36-37"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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