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Spike and Slab Regression for Nonstationary Gaussian Linear Mixed Effects Modeling of Rapid Disease Progression 快速疾病进展的非平稳高斯线性混合效应模型的尖峰和平板回归
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-05 DOI: 10.1002/env.2884
Emrah Gecili, Cole Brokamp, Özgür Asar, Eleni-Rosalina Andrinopoulou, John J. Brewington, Rhonda D. Szczesniak

Select measures of social and environmental determinants of health (referred to as “geomarkers”), predict rapid lung function decline in cystic fibrosis (CF), defined as a prolonged decline relative to patient and/or center-level norms. The extent to which hyper-localization, defined as increasing the spatiotemporal precision of geomarkers, aids in prediction of rapid lung decline remains unclear. Linear mixed effects (LME) models with specialized covariance functions have been used for predicting rapid lung function decline, but there are few options to properly incorporate spatial correlation into the covariance functions while inducing simultaneous variable selection. Our innovative Bayesian model uses a spike and slab prior for simultaneous variable selection and offers additional advantages when coupled with nonstationary Gaussian LME modeling. This model also incorporates spatial correlation through an additional random effect term that accounts for spatial correlation based on ZIP code distances. We validated the model with simulations and applied it to real CF data from a Midwestern CF Center. We demonstrate how a combination of demographic, clinical, and geomarker variables can be selected as optimal predictors using Bayesian false discovery rate controlling rule. Our results indicate that incorporating spatiotemporal effects and geomarkers into this novel Bayesian stochastic LME model enhances the dynamic prediction of rapid CF disease progression.

选择健康的社会和环境决定因素(称为“地理标志”)的措施,预测囊性纤维化(CF)的肺功能快速下降,定义为相对于患者和/或中心水平标准的长期下降。高度定位被定义为提高地理标记物的时空精度,在多大程度上有助于预测肺功能的快速衰退,目前尚不清楚。具有专门协方差函数的线性混合效应(LME)模型已被用于预测肺功能的快速衰退,但在诱导同步变量选择的同时,很少有办法将空间相关性适当地纳入协方差函数。我们创新的贝叶斯模型使用峰值和slab先验来同时选择变量,并且在与非平稳高斯LME建模相结合时提供额外的优势。该模型还通过一个额外的随机效应项来考虑基于邮政编码距离的空间相关性,从而结合了空间相关性。我们通过模拟验证了该模型,并将其应用于中西部CF中心的真实CF数据。我们演示了如何使用贝叶斯错误发现率控制规则选择人口统计、临床和地理标记变量的组合作为最佳预测因子。我们的研究结果表明,将时空效应和地理标记纳入这种新的贝叶斯随机LME模型可以增强对CF快速疾病进展的动态预测。
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引用次数: 0
Entropy-Based Assessment of Biodiversity, With Application to Ants' Nests Data 基于熵的生物多样性评价及其在蚁巢数据中的应用
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-30 DOI: 10.1002/env.2885
L. Altieri, D. Cocchi, M. Ventrucci

The present work takes an innovative point of view in the study of a marked point pattern dataset of two ants' species, over an irregular region with a spatial covariate. The approach, based on entropy measures, brings new insights to the interpretation of the behavior of such ants' nesting habits, which can be exploited in the general area of biodiversity evaluation. We make proper use of descriptive entropy measures and inferential approaches, performing a comparative study of their uncertainty and interpretability in the context of biodiversity. For the first time in the study of these ants' nests data, all the available information is fully exploited, and interpretation guidelines are given for assessing both the observed and the latent biodiversity of the system, with a simultaneous consideration of spatial structures, covariate and interpoint interaction effects. Computations are supported by the new release of our R package SpatEntropy.

目前的工作采取了一个创新的观点,在两个蚂蚁物种的标记点模式数据集的研究,在一个不规则的区域与空间协变量。该方法基于熵测度,为蚁群筑巢习性的解释提供了新的视角,可用于生物多样性评价的一般领域。我们适当地利用描述性熵测度和推理方法,对它们在生物多样性背景下的不确定性和可解释性进行了比较研究。在对这些蚁巢数据的研究中,首次充分利用了所有可用信息,并在同时考虑空间结构、协变量和点间相互作用的情况下,为评估系统的观察和潜在生物多样性提供了解释指南。新版本的R包SpatEntropy支持计算。
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引用次数: 0
Modeling nonstationary surface-level ozone extremes through the lens of US air quality standards: A Bayesian hierarchical approach 通过美国空气质量标准模拟非平稳地表臭氧极端:贝叶斯分层方法
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-27 DOI: 10.1002/env.2882
Jax Li, Brook T. Russell, Whitney K. Huang, William C. Porter
<p>Surface-level ozone (O<span></span><math> <semantics> <mrow> <msub> <mo> </mo> <mrow> <mn>3</mn> </mrow> </msub> </mrow> <annotation>$$ {}_3 $$</annotation> </semantics></math>) is a harmful air pollutant whose effects may be more deleterious when at its most extreme levels. Current US air quality standards are written in terms of the 3-year average of the 4th highest annual daily maximum 8-h O<span></span><math> <semantics> <mrow> <msub> <mo> </mo> <mrow> <mn>3</mn> </mrow> </msub> </mrow> <annotation>$$ {}_3 $$</annotation> </semantics></math> values; therefore, developing approaches based on extreme value theory may be useful. We develop a Bayesian hierarchical approach, where the <span></span><math> <semantics> <mrow> <mi>r</mi> </mrow> <annotation>$$ r $$</annotation> </semantics></math>-largest order statistics are parametrized by the generalized extreme value (GEV) distribution, while a Gaussian process is employed to characterize how the GEV parameters depend on the O<span></span><math> <semantics> <mrow> <msub> <mo> </mo> <mrow> <mn>3</mn> </mrow> </msub> </mrow> <annotation>$$ {}_3 $$</annotation> </semantics></math> precursors, namely nitrous oxides (NO<span></span><math> <semantics> <mrow> <msub> <mo> </mo> <mrow> <mi>x</mi> </mrow> </msub> </mrow> <annotation>$$ {}_x $$</annotation> </semantics></math>) and volatile organic compounds (VOCs). The fitted model is then used to characterize the upper tail of the distribution of O<span></span><math> <semantics> <mrow> <msub> <mo> </mo> <mrow> <mn>3</mn> </mrow> </msub> </mrow> <annotation>$$ {}_3 $$</annotation> </semantics></math> and estimate O<span></span><math> <semantics> <mrow> <msub> <mo> </mo>
地表臭氧(o3 $$ {}_3 $$)是一种有害的空气污染物,其影响在其最极端水平时可能更加有害。目前的美国空气质量标准是根据第4高的年日最大8-h O 3 $$ {}_3 $$值的3年平均值编写的;因此,发展基于极值理论的方法可能是有用的。我们开发了一种贝叶斯分层方法,其中r $$ r $$最大阶统计量由广义极值(GEV)分布参数化,而高斯过程被用来描述GEV参数如何依赖于O 3 $$ {}_3 $$前体,即氧化亚氮(NO x $$ {}_x $$)和挥发性有机化合物(VOCs)。然后使用拟合的模型来表征o3 $$ {}_3 $$分布的上尾并估计o3$$ {}_3 $$违规概率。我们使用来自罗德岛州普罗维登斯的空气质量站的数据来说明所提出的方法。结果表明,极端o3 $$ {}_3 $$值的远上尾可能是有界的,上尾分布对NO x $$ {}_x $$和O 3的依赖关系$$ {}_3 $$是高度非线性的,与现有科学文献中已知的关系一致,尽管不是特别针对极端值。使用基于卷积的方法来估计几种协变量场景的不合规概率。我们的研究结果表明,近年来估计的不合规概率远低于20世纪90年代中期,主要是由于较低的o3 $$ {}_3 $$前体水平。然而,对于假设的更严格的o3 $$ {}_3 $$标准,估计的不合规概率似乎急剧上升,即使是在近年来观察到的情况下。
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引用次数: 0
A Separable Bootstrap Variance Estimation Algorithm for Hierarchical Model-Based Inference of Forest Aboveground Biomass Using Data From NASA's GEDI and Landsat Missions 基于层次模型推断森林地上生物量的可分离自举方差估计算法(基于NASA GEDI和Landsat任务数据
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-22 DOI: 10.1002/env.2883
Svetlana Saarela, Sean P. Healey, Zhiqiang Yang, Bjørn-Eirik Roald, Paul L. Patterson, Terje Gobakken, Erik Næsset, Zhengyang Hou, Ronald E. McRoberts, Göran Ståhl

The hierarchical model-based (HMB) statistical method is currently applied in connection with NASA's Global Ecosystem Dynamics Investigation (GEDI) mission for assessing forest aboveground biomass (AGB) in areas lacking a sufficiently large number of GEDI footprints for employing hybrid inference. This study focuses on variance estimation using a bootstrap procedure that separates the computations into parts, thus considerably reducing the computational time required and making bootstrapping a viable option in this context. The procedure we propose uses a theoretical decomposition of the HMB variance into two parts. Through this decomposition, each variance component can be estimated separately and simultaneously. For demonstrating the proposed procedure, we applied a square-root-transformed ordinary least squares (OLS) model, and parametric bootstrapping, in the first modeling step of HMB. In the second step, we applied a random forest model and pairwise bootstrapping. Monte Carlo simulations showed that the proposed variance estimator is approximately unbiased. The study was performed on an artificial copula-generated population that mimics forest conditions in Oregon, USA, using a dataset comprising AGB, GEDI, and Landsat variables.

基于层次模型(HMB)的统计方法目前应用于美国宇航局的全球生态系统动力学调查(GEDI)任务,用于评估缺乏足够数量的GEDI足迹的地区的森林地上生物量(AGB)。本研究的重点是方差估计,使用一个自举过程,将计算分成几个部分,从而大大减少了所需的计算时间,并使自举在这种情况下成为一个可行的选择。我们提出的方法是将HMB方差的理论分解为两部分。通过这种分解,可以对各个方差分量进行单独和同时的估计。为了证明所提出的过程,我们在HMB的第一步建模中应用了平方根变换的普通最小二乘(OLS)模型和参数自举。在第二步中,我们应用了随机森林模型和两两自举。蒙特卡罗模拟表明,所提出的方差估计器是近似无偏的。该研究是在模拟美国俄勒冈州森林条件的人工交配种群上进行的,使用的数据集包括AGB、GEDI和Landsat变量。
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引用次数: 0
Bias correction of daily precipitation from climate models, using the Q-GAM method 利用 Q-GAM 方法对气候模型的日降水量进行偏差校正
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-25 DOI: 10.1002/env.2881
Georgia Lazoglou, Theo Economou, Christina Anagnostopoulou, Anna Tzyrkalli, George Zittis, Jos Lelieveld

Climate models are useful tools for analyzing historical and projecting future climate conditions. However, the model results tend to differ systematically from observations, particularly for parameters with complex spatial and temporal distributions such as precipitation. A combination of quantile mapping and generalized additive models (GAMs) is presented and proposed as a new method (Q-GAM) for the bias correction of daily precipitation. Q-GAM is demonstrated by using data from five European stations with different climate characteristics. For each station, the closest continental grid point of a EURO-CORDEX climate model was selected for bias correction. A bootstrapping experiment is presented with over 1000 repetitions of randomly splitting the historical period 1981 to 2005 into a calibration and evaluation period. The results for all stations reveal that Q-GAM is a straightforward, accurate and computationally efficient method for the bias correction of precipitation. In particular, the method improves the frequency of dry days and the total annual rainfall amount. This outcome is robust across stations with varying climate characteristics and also to the choice of calibration and evaluation periods. Similar results are also obtained for other precipitation characteristics such as the 0.9 and 0.95 quantiles.

气候模式是分析历史和预测未来气候条件的有用工具。然而,模式结果往往与观测结果存在系统性差异,特别是对于降水等具有复杂时空分布的参数。本文介绍了量子绘图和广义加法模型(GAMs)的结合,并提出了一种新方法(Q-GAM),用于日降水量的偏差校正。通过使用具有不同气候特征的五个欧洲站点的数据,对 Q-GAM 进行了演示。每个站点都选择了 EURO-CORDEX 气候模式中最接近的大陆网格点进行偏差校正。对 1981 年至 2005 年这一历史时期随机分成校准期和评估期,进行了超过 1000 次重复的引导实验。所有站点的结果表明,Q-GAM 是一种直接、准确、计算效率高的降水偏差校正方法。特别是,该方法提高了干旱日的频率和年降雨总量。这一结果对不同气候特征的站点以及校准和评估期的选择都是稳健的。对于其他降水特征,如 0.9 和 0.95 量值,也得到了类似的结果。
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引用次数: 0
A hierarchical constrained density regression model for predicting cluster-level dose-response 用于预测群集级剂量反应的分层约束密度回归模型
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-26 DOI: 10.1002/env.2880
Michael L. Pennell, Matthew W. Wheeler, Scott S. Auerbach

With the advent of new alternative methods for rapid toxicity screening of chemicals comes the need for new statistical methodologies which appropriately synthesize the large amount of data collected. For example, transcriptomic assays can be used to assess the impact of a chemical on thousands of genes, but current approaches to analyzing the data treat each gene separately and do not allow sharing of information among genes within pathways. Furthermore, the methods employed are fully parametric and do not account for changes in distribution shape that may occur at high exposure levels. To address the limitations of these methods, we propose Constrained Logistic Density Regression (COLDER) to model expression data from different genes simultaneously. Under COLDER, the dose-response function for each gene is assigned a prior via a discrete logistic stick-breaking process (LSBP) whose weights depend on gene-level characteristics (e.g., pathway membership) and atoms consist of different dose-response functions subject to a shape constraint that ensures biological plausibility. The posterior distribution for the benchmark dose among genes within the same pathways can be estimated directly from the model, which is another advantage over current methods. The ability of COLDER to predict gene-level dose-response is evaluated in a simulation study and the method is illustrated with data from a National Toxicology Program study of Aflatoxin B1.

随着用于快速筛选化学品毒性的新替代方法的出现,我们需要新的统计方法来适当综合收集到的大量数据。例如,转录组测定可用于评估化学品对数千个基因的影响,但目前的数据分析方法是将每个基因分开处理,不允许在通路中共享基因间的信息。此外,所采用的方法都是完全参数化的,没有考虑到高暴露水平下可能出现的分布形状变化。为了解决这些方法的局限性,我们提出了约束逻辑密度回归(COLDER)方法,以同时对不同基因的表达数据进行建模。在 COLDER 中,每个基因的剂量-反应函数都通过离散逻辑断棒过程(LSBP)分配一个先验值,该先验值的权重取决于基因水平特征(如通路成员资格),原子由不同的剂量-反应函数组成,并受到确保生物合理性的形状约束。同一通路中基因间基准剂量的后验分布可直接从模型中估算,这是目前方法的另一个优势。COLDER 预测基因水平剂量反应的能力在一项模拟研究中进行了评估,并用国家毒理学计划对黄曲霉毒素 B1 的研究数据对该方法进行了说明。
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引用次数: 0
Under the mantra: ‘Make use of colorblind friendly graphs’ 以 "使用色盲友好图表 "为口号
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-20 DOI: 10.1002/env.2877
Duccio Rocchini, Ludovico Chieffallo, Elisa Thouverai, Rossella D'Introno, Francesca Dagostin, Emma Donini, Giles Foody, Simon Garnier, Guilherme G. Mazzochini, Vitezslav Moudry, Bob Rudis, Petra Simova, Michele Torresani, Jakub Nowosad

Colorblindness is a genetic condition that affects a person's ability to accurately perceive colors. Several papers still exist making use of rainbow colors palette to show output. In such cases, for colorblind people such graphs are meaningless. In this paper, we propose good practices and coding solutions developed in the R Free and Open Source Software to (i) simulate colorblindness, (ii) develop colorblind friendly color palettes and (iii) provide the tools for converting a noncolorblind friendly graph into a new image with improved colors.

色盲是一种遗传病,会影响人准确感知颜色的能力。目前仍有一些论文使用彩虹色调色板来显示输出结果。在这种情况下,对于色盲者来说,这些图表毫无意义。在本文中,我们提出了在 R 免费开源软件中开发的良好实践和编码解决方案,以便:(i) 模拟色盲;(ii) 开发色盲友好型调色板;(iii) 提供工具,将非色盲友好型图形转换为具有改进色彩的新图像。
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引用次数: 0
A flexible and interpretable spatial covariance model for data on graphs 灵活、可解释的图形数据空间协方差模型
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-17 DOI: 10.1002/env.2879
Michael F. Christensen, Peter D. Hoff

Spatial models for areal data are often constructed such that all pairs of adjacent regions are assumed to have near-identical spatial autocorrelation. In practice, data can exhibit dependence structures more complicated than can be represented under this assumption. In this article, we develop a new model for spatially correlated data observed on graphs, which can flexibly represented many types of spatial dependence patterns while retaining aspects of the original graph geometry. Our method implies an embedding of the graph into Euclidean space wherein covariance can be modeled using traditional covariance functions, such as those from the Matérn family. We parameterize our model using a class of graph metrics compatible with such covariance functions, and which characterize distance in terms of network flow, a property useful for understanding proximity in many ecological settings. By estimating the parameters underlying these metrics, we recover the “intrinsic distances” between graph nodes, which assist in the interpretation of the estimated covariance and allow us to better understand the relationship between the observed process and spatial domain. We compare our model to existing methods for spatially dependent graph data, primarily conditional autoregressive models and their variants, and illustrate advantages of our method over traditional approaches. We fit our model to bird abundance data for several species in North Carolina, and show how it provides insight into the interactions between species-specific spatial distributions and geography.

通常构建的等值数据空间模型是假设所有相邻区域对都具有近乎相同的空间自相关性。实际上,数据可能表现出比这一假设更复杂的依赖结构。在本文中,我们为在图形上观察到的空间相关数据建立了一个新模型,它可以灵活地表示多种类型的空间依赖模式,同时保留了原始图形几何的某些方面。我们的方法意味着将图嵌入欧几里得空间,其中的协方差可以使用传统的协方差函数建模,例如马特恩函数族中的协方差函数。我们使用一类与此类协方差函数兼容的图度量来对模型进行参数化,这些度量以网络流来描述距离,这一特性有助于理解许多生态环境中的邻近性。通过估计这些度量的基本参数,我们可以恢复图节点之间的 "固有距离",这有助于解释估计的协方差,使我们能够更好地理解观察到的过程与空间域之间的关系。我们将我们的模型与现有的空间依赖图数据方法(主要是条件自回归模型及其变体)进行了比较,并说明了我们的方法与传统方法相比的优势。我们将我们的模型拟合到北卡罗来纳州多个物种的鸟类丰度数据中,并展示了该模型如何深入揭示物种特定空间分布与地理之间的相互作用。
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引用次数: 0
How to find the best sampling design: A new measure of spatial balance 如何找到最佳抽样设计:空间平衡的新衡量标准
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-13 DOI: 10.1002/env.2878
Wilmer Prentius, Anton Grafström

We present a novel measure to assess the spatial balance of a sample by utilizing the balancing equation, which captures the balance between the sample units and their neighbours. Spatially balanced samples are desirable as they may reduce the variance of an estimator of a population parameter. If the auxiliary variables we employ to spread the sample possess high explanatory power for the variable(s) of interest, the resulting reduction in variance can be substantial. An advantageous aspect of using auxiliary variables is that their availability is not contingent upon the sampling effort. Therefore, we can assess and compare sampling designs before committing resources to full-scale surveys. By comparing the proposed measure with commonly used measures of spatial balance, we ascertain that our measure consistently yields meaningful insights regarding the spatial balance of samples. Consequently, our measure can effectively differentiate between various designs when planning a survey, evaluate the potential gains from replacing an existing sample, and determine which non-responding units would contribute the most to enhancing the set of responding units.

我们提出了一种新的方法,利用平衡方程来评估样本的空间平衡,该方程可捕捉样本单元与其邻近单元之间的平衡。空间平衡的样本是理想的,因为它们可以减少人口参数估计的方差。如果我们用来分散样本的辅助变量对相关变量具有很强的解释能力,那么由此带来的方差减少可能会非常可观。使用辅助变量的一个好处是,它们的可用性并不取决于抽样工作。因此,在投入资源进行全面调查之前,我们可以对抽样设计进行评估和比较。通过将所提出的测量方法与常用的空间平衡测量方法进行比较,我们可以确定,我们的测量方法始终能就样本的空间平衡提供有意义的见解。因此,在规划调查时,我们的测量方法可以有效区分各种设计,评估替换现有样本的潜在收益,并确定哪些非响应单位最有助于增强响应单位集。
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引用次数: 0
Anthropogenic and meteorological effects on the counts and sizes of moderate and extreme wildfires 人类活动和气象对中度和极端野火数量和规模的影响
IF 1.5 3区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-06 DOI: 10.1002/env.2873
Elizabeth S. Lawler, Benjamin A. Shaby

The growing frequency and size of wildfires across the US necessitates accurate quantitative assessment of evolving wildfire behavior to predict risk from future extreme wildfires. We build a joint model of wildfire counts and burned areas, regressing key model parameters on climate and demographic covariates. We use extended generalized Pareto distributions to model the full distribution of burned areas, capturing both moderate and extreme sizes, while leveraging extreme value theory to focus particularly on the right tail. We model wildfire counts with a zero-inflated negative binomial model, and join the wildfire counts and burned areas sub-models using a temporally-varying shared random effect. Our model successfully captures the trends of wildfire counts and burned areas. By investigating the predictive power of different sets of covariates, we find that fire indices are better predictors of wildfire burned area behavior than individual climate covariates, whereas climate covariates are influential drivers of wildfire occurrence behavior.

美国各地野火发生的频率和规模越来越大,因此有必要对不断演变的野火行为进行准确的定量评估,以预测未来极端野火的风险。我们建立了一个野火数量和烧毁面积的联合模型,将模型的关键参数与气候和人口协变量进行回归。我们使用扩展的广义帕累托分布来模拟燃烧面积的完整分布,同时捕捉中等和极端面积,并利用极值理论特别关注右尾部。我们使用零膨胀负二项模型对野火数量进行建模,并使用随时间变化的共享随机效应将野火数量和烧毁面积子模型连接起来。我们的模型成功地捕捉到了野火次数和烧毁面积的变化趋势。通过研究不同协变量的预测能力,我们发现火灾指数比单个气候协变量更能预测野火烧毁面积行为,而气候协变量则是野火发生行为的影响因素。
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引用次数: 0
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