Pub Date : 2024-02-13DOI: 10.9734/jammr/2024/v36i25369
FA Valentini, BG Marti, PE Zimmern
Aims: Detrusor contractility governs the voiding process. Its evaluation in women derived from an intubated flow is obtained from the contractility indices PIP1 and the VBN-derived parameter k. Both values of PIP1 and k are dependent of the urodynamic diagnosis (UD) and decrease with aging. Our goal was to find out if one of these indexes was more informative depending on UD and age. Methods: Contractility was evaluated from pressure-flow studies of 354 non-neurologic women (age range 20-96 y) who were referred for investigation of various lower urinary tract dysfunctions and who fulfilled criteria for inclusion: non-interrupted flow, voided volume >100 mL and Qmax> 2mL/s. UD were bladder outlet obstruction (BOO), detrusor hyperactivity with impaired contractility (DHIC), detrusor overactivity (DO), detrusor underactivity (DU). Some investigations were found “normal” (N) and other related to urethral dysfunction (intrinsic sphincter deficiency (ISD)) or voiding triggered by urethral relaxation (URA)). Data were interpreted across age-groups with 20 years interval, at least 3 patients with one UD in a given age-group interval. Results: Among all the UD, only 2 did not have a sufficient number of patients to be reported: DHIC for 20-40y and URA for >80y. For each UD, variations of k and PIP1 demonstrated a decrease with age, which was more important for k in the age group >80y (compared with all age groups). Age–groups 20-40 and 41-60 gave comparable values of k and PIP1 for UD BOO, DO and DU. Analysis of percentage of contractility value variation showed a more important and significant decrease for k vs. PIP1 between age-groups 61-80 and >80 for all UD (p=.0028). Conclusions: If both detrusor contractility indexes have values well related to urodynamic diagnosis which decrease with age, use of k is more informative than PIP1 in elderly women.
目的：决尿器收缩力控制着排尿过程。PIP1 和 k 值均取决于尿动力学诊断（UD），并随着年龄的增长而降低。我们的目标是找出这些指标中是否有一个指标在尿动力学诊断和年龄上更有参考价值。方法：对 354 名非神经病女性（年龄在 20-96 岁之间）的压力-流量研究进行了收缩力评估，这些女性因各种下尿路功能障碍接受了转诊检查，并符合纳入标准：无中断尿流、排尿量大于 100 毫升且 Qmax 大于 2 毫升/秒。下尿路功能障碍包括膀胱出口梗阻（BOO）、收缩力受损的逼尿肌过度活动（DHIC）、逼尿肌过度活动（DO）和逼尿肌活动不足（DU）。有些检查结果为 "正常"（N），有些则与尿道功能障碍（内在括约肌缺陷（ISD））或尿道松弛引发的排尿（URA）有关。）对不同年龄组的数据进行了解读，每组间隔 20 年，在特定年龄组中至少有 3 名患者患有尿失禁。结果显示在所有尿道松弛症中，只有 2 例患者人数不足，无法报告：20-40岁的DHIC和80岁以上的URA。在每个 UD 中，k 和 PIP1 的变化随着年龄的增长而减小，其中大于 80 岁年龄组的 k 变化更大（与所有年龄组相比）。20-40 岁和 41-60 岁年龄组的 UD BOO、DO 和 DU 的 k 和 PIP1 值相当。对收缩力值变化百分比的分析表明，在所有 UD 中，61-80 岁年龄组和大于 80 岁年龄组的 k 值与 PIP1 值相比有更重要和更显著的下降（p=.0028）。结论如果两种逼尿肌收缩力指数的值都与尿动力学诊断密切相关，并且随着年龄的增长而降低，那么在老年妇女中使用 k 比 PIP1 更有参考价值。
{"title":"Determining the Ideal Index for Assessing Detrusor Contractility in Women: Insights from Urodynamic Diagnosis and Age","authors":"FA Valentini, BG Marti, PE Zimmern","doi":"10.9734/jammr/2024/v36i25369","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25369","url":null,"abstract":"Aims: Detrusor contractility governs the voiding process. Its evaluation in women derived from an intubated flow is obtained from the contractility indices PIP1 and the VBN-derived parameter k. Both values of PIP1 and k are dependent of the urodynamic diagnosis (UD) and decrease with aging. Our goal was to find out if one of these indexes was more informative depending on UD and age. \u0000Methods: Contractility was evaluated from pressure-flow studies of 354 non-neurologic women (age range 20-96 y) who were referred for investigation of various lower urinary tract dysfunctions and who fulfilled criteria for inclusion: non-interrupted flow, voided volume >100 mL and Qmax> 2mL/s. \u0000UD were bladder outlet obstruction (BOO), detrusor hyperactivity with impaired contractility (DHIC), detrusor overactivity (DO), detrusor underactivity (DU). Some investigations were found “normal” (N) and other related to urethral dysfunction (intrinsic sphincter deficiency (ISD)) or voiding triggered by urethral relaxation (URA)). Data were interpreted across age-groups with 20 years interval, at least 3 patients with one UD in a given age-group interval. \u0000Results: Among all the UD, only 2 did not have a sufficient number of patients to be reported: DHIC for 20-40y and URA for >80y. For each UD, variations of k and PIP1 demonstrated a decrease with age, which was more important for k in the age group >80y (compared with all age groups). Age–groups 20-40 and 41-60 gave comparable values of k and PIP1 for UD BOO, DO and DU. Analysis of percentage of contractility value variation showed a more important and significant decrease for k vs. PIP1 between age-groups 61-80 and >80 for all UD (p=.0028). \u0000Conclusions: If both detrusor contractility indexes have values well related to urodynamic diagnosis which decrease with age, use of k is more informative than PIP1 in elderly women.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"69 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139841608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-13DOI: 10.9734/jammr/2024/v36i25369
FA Valentini, BG Marti, PE Zimmern
Aims: Detrusor contractility governs the voiding process. Its evaluation in women derived from an intubated flow is obtained from the contractility indices PIP1 and the VBN-derived parameter k. Both values of PIP1 and k are dependent of the urodynamic diagnosis (UD) and decrease with aging. Our goal was to find out if one of these indexes was more informative depending on UD and age. Methods: Contractility was evaluated from pressure-flow studies of 354 non-neurologic women (age range 20-96 y) who were referred for investigation of various lower urinary tract dysfunctions and who fulfilled criteria for inclusion: non-interrupted flow, voided volume >100 mL and Qmax> 2mL/s. UD were bladder outlet obstruction (BOO), detrusor hyperactivity with impaired contractility (DHIC), detrusor overactivity (DO), detrusor underactivity (DU). Some investigations were found “normal” (N) and other related to urethral dysfunction (intrinsic sphincter deficiency (ISD)) or voiding triggered by urethral relaxation (URA)). Data were interpreted across age-groups with 20 years interval, at least 3 patients with one UD in a given age-group interval. Results: Among all the UD, only 2 did not have a sufficient number of patients to be reported: DHIC for 20-40y and URA for >80y. For each UD, variations of k and PIP1 demonstrated a decrease with age, which was more important for k in the age group >80y (compared with all age groups). Age–groups 20-40 and 41-60 gave comparable values of k and PIP1 for UD BOO, DO and DU. Analysis of percentage of contractility value variation showed a more important and significant decrease for k vs. PIP1 between age-groups 61-80 and >80 for all UD (p=.0028). Conclusions: If both detrusor contractility indexes have values well related to urodynamic diagnosis which decrease with age, use of k is more informative than PIP1 in elderly women.
目的：决尿器收缩力控制着排尿过程。PIP1 和 k 值均取决于尿动力学诊断（UD），并随着年龄的增长而降低。我们的目标是找出这些指数中是否有一个指数在尿动力学诊断和年龄上更有参考价值。方法：对 354 名非神经病女性（年龄在 20-96 岁之间）的压力-流量研究进行了收缩力评估，这些女性因各种下尿路功能障碍接受了转诊检查，并符合纳入标准：无中断尿流、排尿量大于 100 毫升且 Qmax 大于 2 毫升/秒。下尿路功能障碍包括膀胱出口梗阻（BOO）、收缩力受损的逼尿肌过度活动（DHIC）、逼尿肌过度活动（DO）和逼尿肌活动不足（DU）。有些检查结果为 "正常"（N），有些则与尿道功能障碍（内在括约肌缺陷（ISD））或尿道松弛引发的排尿（URA）有关。）对不同年龄组的数据进行了解读，每组间隔 20 年，在特定年龄组中至少有 3 名患者患有尿失禁。结果显示在所有尿道松弛症中，只有 2 例患者人数不足，无法报告：20-40岁的DHIC和80岁以上的URA。在每个 UD 中，k 和 PIP1 的变化随着年龄的增长而减小，其中大于 80 岁年龄组的 k 变化更大（与所有年龄组相比）。20-40 岁和 41-60 岁年龄组的 UD BOO、DO 和 DU 的 k 和 PIP1 值相当。收缩力值变化百分比分析表明，在所有 UD 中，61-80 岁年龄组与大于 80 岁年龄组之间的 k 值与 PIP1 值相比，下降幅度更大且更显著（p=.0028）。结论如果两种逼尿肌收缩力指数的值都与尿动力学诊断密切相关，并且随着年龄的增长而降低，那么在老年妇女中使用 k 比 PIP1 更有参考价值。
{"title":"Determining the Ideal Index for Assessing Detrusor Contractility in Women: Insights from Urodynamic Diagnosis and Age","authors":"FA Valentini, BG Marti, PE Zimmern","doi":"10.9734/jammr/2024/v36i25369","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25369","url":null,"abstract":"Aims: Detrusor contractility governs the voiding process. Its evaluation in women derived from an intubated flow is obtained from the contractility indices PIP1 and the VBN-derived parameter k. Both values of PIP1 and k are dependent of the urodynamic diagnosis (UD) and decrease with aging. Our goal was to find out if one of these indexes was more informative depending on UD and age. \u0000Methods: Contractility was evaluated from pressure-flow studies of 354 non-neurologic women (age range 20-96 y) who were referred for investigation of various lower urinary tract dysfunctions and who fulfilled criteria for inclusion: non-interrupted flow, voided volume >100 mL and Qmax> 2mL/s. \u0000UD were bladder outlet obstruction (BOO), detrusor hyperactivity with impaired contractility (DHIC), detrusor overactivity (DO), detrusor underactivity (DU). Some investigations were found “normal” (N) and other related to urethral dysfunction (intrinsic sphincter deficiency (ISD)) or voiding triggered by urethral relaxation (URA)). Data were interpreted across age-groups with 20 years interval, at least 3 patients with one UD in a given age-group interval. \u0000Results: Among all the UD, only 2 did not have a sufficient number of patients to be reported: DHIC for 20-40y and URA for >80y. For each UD, variations of k and PIP1 demonstrated a decrease with age, which was more important for k in the age group >80y (compared with all age groups). Age–groups 20-40 and 41-60 gave comparable values of k and PIP1 for UD BOO, DO and DU. Analysis of percentage of contractility value variation showed a more important and significant decrease for k vs. PIP1 between age-groups 61-80 and >80 for all UD (p=.0028). \u0000Conclusions: If both detrusor contractility indexes have values well related to urodynamic diagnosis which decrease with age, use of k is more informative than PIP1 in elderly women.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"15 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139781774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: To analyze the impact of clinical severity on maternal and perinatal outcomes across trimesters in coronavirus disease 2019 (COVID-19) pregnancies. Study design: This was a prospective open cohort study of pregnant women with COVID-19 during the prenatal, delivery, postpartum periods from September 2020 to March 2022. Methodology: For data analysis, 132 pregnant women who had no pre-existing comorbidities or pregnancy-related complications at the beginning of the cohort were selected. Data related to COVID-19, demographic, clinical, obstetric, laboratory, ultrasound and birth outcomes were collected. Results: A total of 132 pregnant women with COVID-19 were followed up for 2237 women-week. Among them, 19.7% experienced maternal complications such as premature rupture of membranes (19.7%), premature delivery (10.6%), postpartum hemorrhage (8.3%), and preeclampsia (6.8%), or fetal/neonatal complications, including small for gestational age (9.1%), need for neonatal intensive care unit (9.1%), and acute fetal distress (6.1%). Having moderate/severe COVID-19 on prenatal care admission (hazard ratio (HR):3.75) and 95% confidence interval (CI95%):1.63; 8.61 or contracting the infection during the second (HR: 6.35; CI95%: 2.35; 17.17) or third trimester (HR:14.35; CI95%:4.85; 42.41) of pregnancy were significantly associated with these maternal complications. Similarly, having moderate/severe COVID-19 on prenatal care admission (HR:3.90; CI95%:1.48; 10.24) or contracting the infection during the second (HR:6.84; CI95%:2.05; 22.84) or third trimester (HR:22.4; CI95%:6.57; 76.33) of pregnancy were also associated with fetal/neonatal complications. Conclusion: Pregnant women with COVID-19 have a higher risk of maternal or fetal/neonatal complications if they present with a moderate/severe COVID-19 on prenatal care admission or if the infection occurs in the second or third trimester of pregnancy.
{"title":"Impact of Clinical Severity on Maternal and Perinatal Outcome Across Trimesters in COVID 19 Pregnancies: A Prospective Cohort Study","authors":"Kubiszeski EH, Carmo MAMV, Carmo AV, Rosa Aancr, Carvalho AMB, Souza NS, Fontes CJ, Galera MF","doi":"10.9734/jammr/2024/v36i25367","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25367","url":null,"abstract":"Aims: To analyze the impact of clinical severity on maternal and perinatal outcomes across trimesters in coronavirus disease 2019 (COVID-19) pregnancies. \u0000Study design: This was a prospective open cohort study of pregnant women with COVID-19 during the prenatal, delivery, postpartum periods from September 2020 to March 2022. \u0000Methodology: For data analysis, 132 pregnant women who had no pre-existing comorbidities or pregnancy-related complications at the beginning of the cohort were selected. Data related to COVID-19, demographic, clinical, obstetric, laboratory, ultrasound and birth outcomes were collected. \u0000Results: A total of 132 pregnant women with COVID-19 were followed up for 2237 women-week. Among them, 19.7% experienced maternal complications such as premature rupture of membranes (19.7%), premature delivery (10.6%), postpartum hemorrhage (8.3%), and preeclampsia (6.8%), or fetal/neonatal complications, including small for gestational age (9.1%), need for neonatal intensive care unit (9.1%), and acute fetal distress (6.1%). Having moderate/severe COVID-19 on prenatal care admission (hazard ratio (HR):3.75) and 95% confidence interval (CI95%):1.63; 8.61 or contracting the infection during the second (HR: 6.35; CI95%: 2.35; 17.17) or third trimester (HR:14.35; CI95%:4.85; 42.41) of pregnancy were significantly associated with these maternal complications. Similarly, having moderate/severe COVID-19 on prenatal care admission (HR:3.90; CI95%:1.48; 10.24) or contracting the infection during the second (HR:6.84; CI95%:2.05; 22.84) or third trimester (HR:22.4; CI95%:6.57; 76.33) of pregnancy were also associated with fetal/neonatal complications. \u0000Conclusion: Pregnant women with COVID-19 have a higher risk of maternal or fetal/neonatal complications if they present with a moderate/severe COVID-19 on prenatal care admission or if the infection occurs in the second or third trimester of pregnancy.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"51 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.9734/jammr/2024/v36i25368
C. Yao-Yapo, E. Yayo, K. A. M. Kouacou, J. L. Konan, Y. C. Kouamé-Dia, A. J. Koffi, Y. B. Koné, D. A. Gnionsahié, M. Attoungbré, D. Monnet
Introduction: Bone metabolism disorders are one of the most frequent and serious complications of kidney disease, and are associated with high morbidity and mortality. In order to prevent these bone complications, the Kidney Disease Improving Global Outcomes (KDIGO) expert committee recommends maintaining PTH values within a target range dependent on the race of the population and the generation of test used. The aim of this study was to propose target intervals for monitoring PTH in Ivorian haemodialysis patients according to test generation, and to establish the PTH profile of these patients. Materials and Methods: This was an analytical cross-sectional study involving 86 black African subjects in apparent good health for the determination of PTH target intervals and 200 black African haemodialysis patients for the PTH profile. Target ranges were determined simultaneously on a 2nd generation Maglumi 800 and 3rd generation kit Vidas (Whole PTH) according to KDIGO (2009) recommendations. The PTH profile of hemodialysis patients was established in comparison with the pre-established target ranges. Results: The target PTH ranges for dialysis patients were 280.4 to 1261.8 pg/ml for the Maglumi kitÒ and 83.8 to 377.1 pg/ml for the Vidas kitÒ. The mean PTH value in healthy subjects was 21.99 pg/ml, compared with 473.3 pg/ml in haemodialysis patients. According to the target interval established on the VidasÒ kit, 34% of dialysis patients had a PTH value above the upper limit of normality and were therefore at risk of bone complications. Conclusion: The PTH values of black African Ivorian hemodialysis patients according to the pre-established target intervals were significantly higher in our population than those of Caucasian and Asian populations described in the literature.
{"title":"Target Ranges and PTH Profile in A West African Population Using 2nd and 3rd Generation Tests","authors":"C. Yao-Yapo, E. Yayo, K. A. M. Kouacou, J. L. Konan, Y. C. Kouamé-Dia, A. J. Koffi, Y. B. Koné, D. A. Gnionsahié, M. Attoungbré, D. Monnet","doi":"10.9734/jammr/2024/v36i25368","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25368","url":null,"abstract":"Introduction: Bone metabolism disorders are one of the most frequent and serious complications of kidney disease, and are associated with high morbidity and mortality. In order to prevent these bone complications, the Kidney Disease Improving Global Outcomes (KDIGO) expert committee recommends maintaining PTH values within a target range dependent on the race of the population and the generation of test used. The aim of this study was to propose target intervals for monitoring PTH in Ivorian haemodialysis patients according to test generation, and to establish the PTH profile of these patients. \u0000Materials and Methods: This was an analytical cross-sectional study involving 86 black African subjects in apparent good health for the determination of PTH target intervals and 200 black African haemodialysis patients for the PTH profile. Target ranges were determined simultaneously on a 2nd generation Maglumi 800 and 3rd generation kit Vidas (Whole PTH) according to KDIGO (2009) recommendations. The PTH profile of hemodialysis patients was established in comparison with the pre-established target ranges. \u0000Results: The target PTH ranges for dialysis patients were 280.4 to 1261.8 pg/ml for the Maglumi kitÒ and 83.8 to 377.1 pg/ml for the Vidas kitÒ. The mean PTH value in healthy subjects was 21.99 pg/ml, compared with 473.3 pg/ml in haemodialysis patients. According to the target interval established on the VidasÒ kit, 34% of dialysis patients had a PTH value above the upper limit of normality and were therefore at risk of bone complications. \u0000Conclusion: The PTH values of black African Ivorian hemodialysis patients according to the pre-established target intervals were significantly higher in our population than those of Caucasian and Asian populations described in the literature.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"60 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: To analyze the impact of clinical severity on maternal and perinatal outcomes across trimesters in coronavirus disease 2019 (COVID-19) pregnancies. Study design: This was a prospective open cohort study of pregnant women with COVID-19 during the prenatal, delivery, postpartum periods from September 2020 to March 2022. Methodology: For data analysis, 132 pregnant women who had no pre-existing comorbidities or pregnancy-related complications at the beginning of the cohort were selected. Data related to COVID-19, demographic, clinical, obstetric, laboratory, ultrasound and birth outcomes were collected. Results: A total of 132 pregnant women with COVID-19 were followed up for 2237 women-week. Among them, 19.7% experienced maternal complications such as premature rupture of membranes (19.7%), premature delivery (10.6%), postpartum hemorrhage (8.3%), and preeclampsia (6.8%), or fetal/neonatal complications, including small for gestational age (9.1%), need for neonatal intensive care unit (9.1%), and acute fetal distress (6.1%). Having moderate/severe COVID-19 on prenatal care admission (hazard ratio (HR):3.75) and 95% confidence interval (CI95%):1.63; 8.61 or contracting the infection during the second (HR: 6.35; CI95%: 2.35; 17.17) or third trimester (HR:14.35; CI95%:4.85; 42.41) of pregnancy were significantly associated with these maternal complications. Similarly, having moderate/severe COVID-19 on prenatal care admission (HR:3.90; CI95%:1.48; 10.24) or contracting the infection during the second (HR:6.84; CI95%:2.05; 22.84) or third trimester (HR:22.4; CI95%:6.57; 76.33) of pregnancy were also associated with fetal/neonatal complications. Conclusion: Pregnant women with COVID-19 have a higher risk of maternal or fetal/neonatal complications if they present with a moderate/severe COVID-19 on prenatal care admission or if the infection occurs in the second or third trimester of pregnancy.
{"title":"Impact of Clinical Severity on Maternal and Perinatal Outcome Across Trimesters in COVID 19 Pregnancies: A Prospective Cohort Study","authors":"Kubiszeski EH, Carmo MAMV, Carmo AV, Rosa Aancr, Carvalho AMB, Souza NS, Fontes CJ, Galera MF","doi":"10.9734/jammr/2024/v36i25367","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25367","url":null,"abstract":"Aims: To analyze the impact of clinical severity on maternal and perinatal outcomes across trimesters in coronavirus disease 2019 (COVID-19) pregnancies. \u0000Study design: This was a prospective open cohort study of pregnant women with COVID-19 during the prenatal, delivery, postpartum periods from September 2020 to March 2022. \u0000Methodology: For data analysis, 132 pregnant women who had no pre-existing comorbidities or pregnancy-related complications at the beginning of the cohort were selected. Data related to COVID-19, demographic, clinical, obstetric, laboratory, ultrasound and birth outcomes were collected. \u0000Results: A total of 132 pregnant women with COVID-19 were followed up for 2237 women-week. Among them, 19.7% experienced maternal complications such as premature rupture of membranes (19.7%), premature delivery (10.6%), postpartum hemorrhage (8.3%), and preeclampsia (6.8%), or fetal/neonatal complications, including small for gestational age (9.1%), need for neonatal intensive care unit (9.1%), and acute fetal distress (6.1%). Having moderate/severe COVID-19 on prenatal care admission (hazard ratio (HR):3.75) and 95% confidence interval (CI95%):1.63; 8.61 or contracting the infection during the second (HR: 6.35; CI95%: 2.35; 17.17) or third trimester (HR:14.35; CI95%:4.85; 42.41) of pregnancy were significantly associated with these maternal complications. Similarly, having moderate/severe COVID-19 on prenatal care admission (HR:3.90; CI95%:1.48; 10.24) or contracting the infection during the second (HR:6.84; CI95%:2.05; 22.84) or third trimester (HR:22.4; CI95%:6.57; 76.33) of pregnancy were also associated with fetal/neonatal complications. \u0000Conclusion: Pregnant women with COVID-19 have a higher risk of maternal or fetal/neonatal complications if they present with a moderate/severe COVID-19 on prenatal care admission or if the infection occurs in the second or third trimester of pregnancy.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"122 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139785037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.9734/jammr/2024/v36i25368
C. Yao-Yapo, E. Yayo, K. A. M. Kouacou, J. L. Konan, Y. C. Kouamé-Dia, A. J. Koffi, Y. B. Koné, D. A. Gnionsahié, M. Attoungbré, D. Monnet
Introduction: Bone metabolism disorders are one of the most frequent and serious complications of kidney disease, and are associated with high morbidity and mortality. In order to prevent these bone complications, the Kidney Disease Improving Global Outcomes (KDIGO) expert committee recommends maintaining PTH values within a target range dependent on the race of the population and the generation of test used. The aim of this study was to propose target intervals for monitoring PTH in Ivorian haemodialysis patients according to test generation, and to establish the PTH profile of these patients. Materials and Methods: This was an analytical cross-sectional study involving 86 black African subjects in apparent good health for the determination of PTH target intervals and 200 black African haemodialysis patients for the PTH profile. Target ranges were determined simultaneously on a 2nd generation Maglumi 800 and 3rd generation kit Vidas (Whole PTH) according to KDIGO (2009) recommendations. The PTH profile of hemodialysis patients was established in comparison with the pre-established target ranges. Results: The target PTH ranges for dialysis patients were 280.4 to 1261.8 pg/ml for the Maglumi kitÒ and 83.8 to 377.1 pg/ml for the Vidas kitÒ. The mean PTH value in healthy subjects was 21.99 pg/ml, compared with 473.3 pg/ml in haemodialysis patients. According to the target interval established on the VidasÒ kit, 34% of dialysis patients had a PTH value above the upper limit of normality and were therefore at risk of bone complications. Conclusion: The PTH values of black African Ivorian hemodialysis patients according to the pre-established target intervals were significantly higher in our population than those of Caucasian and Asian populations described in the literature.
{"title":"Target Ranges and PTH Profile in A West African Population Using 2nd and 3rd Generation Tests","authors":"C. Yao-Yapo, E. Yayo, K. A. M. Kouacou, J. L. Konan, Y. C. Kouamé-Dia, A. J. Koffi, Y. B. Koné, D. A. Gnionsahié, M. Attoungbré, D. Monnet","doi":"10.9734/jammr/2024/v36i25368","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25368","url":null,"abstract":"Introduction: Bone metabolism disorders are one of the most frequent and serious complications of kidney disease, and are associated with high morbidity and mortality. In order to prevent these bone complications, the Kidney Disease Improving Global Outcomes (KDIGO) expert committee recommends maintaining PTH values within a target range dependent on the race of the population and the generation of test used. The aim of this study was to propose target intervals for monitoring PTH in Ivorian haemodialysis patients according to test generation, and to establish the PTH profile of these patients. \u0000Materials and Methods: This was an analytical cross-sectional study involving 86 black African subjects in apparent good health for the determination of PTH target intervals and 200 black African haemodialysis patients for the PTH profile. Target ranges were determined simultaneously on a 2nd generation Maglumi 800 and 3rd generation kit Vidas (Whole PTH) according to KDIGO (2009) recommendations. The PTH profile of hemodialysis patients was established in comparison with the pre-established target ranges. \u0000Results: The target PTH ranges for dialysis patients were 280.4 to 1261.8 pg/ml for the Maglumi kitÒ and 83.8 to 377.1 pg/ml for the Vidas kitÒ. The mean PTH value in healthy subjects was 21.99 pg/ml, compared with 473.3 pg/ml in haemodialysis patients. According to the target interval established on the VidasÒ kit, 34% of dialysis patients had a PTH value above the upper limit of normality and were therefore at risk of bone complications. \u0000Conclusion: The PTH values of black African Ivorian hemodialysis patients according to the pre-established target intervals were significantly higher in our population than those of Caucasian and Asian populations described in the literature.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"83 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-10DOI: 10.9734/jammr/2024/v36i25365
A. Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães, Renato Mataveli Ferreira Filho, Davydson Gerhardt de Souza, Margareth Maria de Carvalho Queiroz, Carlos Henrique Garção Neto, Paulo Cesar Ribeiro, Júlio Cesar dos Santos Boechat, Kelen Salaroli Viana, Marly Torres Rodrigues da Silva
Background and Aim: In May 2022, the emergence of an outbreak of the Mpox virus was observed across multiple countries, precipitating swift global dissemination. The present Mpox outbreak exhibits unusual characteristics in contrast to antecedent occurrences. A salient peculiarity is the noteworthy incidence of confirmed cases among men who have sex with men. The aim of this research is to discern, within the current scientific literature, the most pertinent and efficacious public health strategies for preventing or mitigating Mpox-related social stigmatization. Methods: Employing the PRISMA model, a systematic review was conducted utilizing PubMed, SciELO, and Google Scholar databases, encompassing articles published from January 2022 to January 2024. Public health strategies to prevent or mitigate Mpox social stigmatization were systematically recorded and summarized for subsequent analysis. Results: Seven articles were identified and analyzed. None of the evaluated articles presented a comprehensive approach concerning public health strategies to counteract social stigmatization amid the Mpox outbreak scenario. The examined studies emphasize the pivotal role of interventions within three axes for public health strategies: awareness and training of healthcare professionals, targeted and sensitive communication addressing the needs of different affected groups, and medical care measures ensuring anonymity and respect for patients. Conclusion: Confronting the proposed strategies with the key issues that trigger stigmatization, it becomes evident that a nuanced calibration of these strategies is required for optimizing the efficacy of public health guidelines implementation. Furthermore, attention to the mental health of Mpox patients is a crucial dimension that cannot be overlooked, given the psychological vulnerability of these individuals, arising from both the disease itself and social stigmatization.
{"title":"Public Health Strategies Against Social Stigma in the Mpox Outbreak: A Systematic Review","authors":"A. Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães, Renato Mataveli Ferreira Filho, Davydson Gerhardt de Souza, Margareth Maria de Carvalho Queiroz, Carlos Henrique Garção Neto, Paulo Cesar Ribeiro, Júlio Cesar dos Santos Boechat, Kelen Salaroli Viana, Marly Torres Rodrigues da Silva","doi":"10.9734/jammr/2024/v36i25365","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25365","url":null,"abstract":"Background and Aim: In May 2022, the emergence of an outbreak of the Mpox virus was observed across multiple countries, precipitating swift global dissemination. The present Mpox outbreak exhibits unusual characteristics in contrast to antecedent occurrences. A salient peculiarity is the noteworthy incidence of confirmed cases among men who have sex with men. The aim of this research is to discern, within the current scientific literature, the most pertinent and efficacious public health strategies for preventing or mitigating Mpox-related social stigmatization. \u0000Methods: Employing the PRISMA model, a systematic review was conducted utilizing PubMed, SciELO, and Google Scholar databases, encompassing articles published from January 2022 to January 2024. Public health strategies to prevent or mitigate Mpox social stigmatization were systematically recorded and summarized for subsequent analysis. \u0000Results: Seven articles were identified and analyzed. None of the evaluated articles presented a comprehensive approach concerning public health strategies to counteract social stigmatization amid the Mpox outbreak scenario. The examined studies emphasize the pivotal role of interventions within three axes for public health strategies: awareness and training of healthcare professionals, targeted and sensitive communication addressing the needs of different affected groups, and medical care measures ensuring anonymity and respect for patients. \u0000Conclusion: Confronting the proposed strategies with the key issues that trigger stigmatization, it becomes evident that a nuanced calibration of these strategies is required for optimizing the efficacy of public health guidelines implementation. Furthermore, attention to the mental health of Mpox patients is a crucial dimension that cannot be overlooked, given the psychological vulnerability of these individuals, arising from both the disease itself and social stigmatization.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139846425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-10DOI: 10.9734/jammr/2024/v36i25365
A. Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães, Renato Mataveli Ferreira Filho, Davydson Gerhardt de Souza, Margareth Maria de Carvalho Queiroz, Carlos Henrique Garção Neto, Paulo Cesar Ribeiro, Júlio Cesar dos Santos Boechat, Kelen Salaroli Viana, Marly Torres Rodrigues da Silva
Background and Aim: In May 2022, the emergence of an outbreak of the Mpox virus was observed across multiple countries, precipitating swift global dissemination. The present Mpox outbreak exhibits unusual characteristics in contrast to antecedent occurrences. A salient peculiarity is the noteworthy incidence of confirmed cases among men who have sex with men. The aim of this research is to discern, within the current scientific literature, the most pertinent and efficacious public health strategies for preventing or mitigating Mpox-related social stigmatization. Methods: Employing the PRISMA model, a systematic review was conducted utilizing PubMed, SciELO, and Google Scholar databases, encompassing articles published from January 2022 to January 2024. Public health strategies to prevent or mitigate Mpox social stigmatization were systematically recorded and summarized for subsequent analysis. Results: Seven articles were identified and analyzed. None of the evaluated articles presented a comprehensive approach concerning public health strategies to counteract social stigmatization amid the Mpox outbreak scenario. The examined studies emphasize the pivotal role of interventions within three axes for public health strategies: awareness and training of healthcare professionals, targeted and sensitive communication addressing the needs of different affected groups, and medical care measures ensuring anonymity and respect for patients. Conclusion: Confronting the proposed strategies with the key issues that trigger stigmatization, it becomes evident that a nuanced calibration of these strategies is required for optimizing the efficacy of public health guidelines implementation. Furthermore, attention to the mental health of Mpox patients is a crucial dimension that cannot be overlooked, given the psychological vulnerability of these individuals, arising from both the disease itself and social stigmatization.
{"title":"Public Health Strategies Against Social Stigma in the Mpox Outbreak: A Systematic Review","authors":"A. Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães, Renato Mataveli Ferreira Filho, Davydson Gerhardt de Souza, Margareth Maria de Carvalho Queiroz, Carlos Henrique Garção Neto, Paulo Cesar Ribeiro, Júlio Cesar dos Santos Boechat, Kelen Salaroli Viana, Marly Torres Rodrigues da Silva","doi":"10.9734/jammr/2024/v36i25365","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25365","url":null,"abstract":"Background and Aim: In May 2022, the emergence of an outbreak of the Mpox virus was observed across multiple countries, precipitating swift global dissemination. The present Mpox outbreak exhibits unusual characteristics in contrast to antecedent occurrences. A salient peculiarity is the noteworthy incidence of confirmed cases among men who have sex with men. The aim of this research is to discern, within the current scientific literature, the most pertinent and efficacious public health strategies for preventing or mitigating Mpox-related social stigmatization. \u0000Methods: Employing the PRISMA model, a systematic review was conducted utilizing PubMed, SciELO, and Google Scholar databases, encompassing articles published from January 2022 to January 2024. Public health strategies to prevent or mitigate Mpox social stigmatization were systematically recorded and summarized for subsequent analysis. \u0000Results: Seven articles were identified and analyzed. None of the evaluated articles presented a comprehensive approach concerning public health strategies to counteract social stigmatization amid the Mpox outbreak scenario. The examined studies emphasize the pivotal role of interventions within three axes for public health strategies: awareness and training of healthcare professionals, targeted and sensitive communication addressing the needs of different affected groups, and medical care measures ensuring anonymity and respect for patients. \u0000Conclusion: Confronting the proposed strategies with the key issues that trigger stigmatization, it becomes evident that a nuanced calibration of these strategies is required for optimizing the efficacy of public health guidelines implementation. Furthermore, attention to the mental health of Mpox patients is a crucial dimension that cannot be overlooked, given the psychological vulnerability of these individuals, arising from both the disease itself and social stigmatization.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"119 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139786446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-10DOI: 10.9734/jammr/2024/v36i25366
Elham Abdullah Elsheraiy Saad, Tarek Ragaey Mohammed, Rabab Mohammed El Soht, Tamer I Abdelhalim
Background: Benign intracranial hypertension (BIH) is a condition in which there is excessive cerebral spinal fluid (CSF) pressure in the subarachnoid space that surrounds the brain and spinal cord (intracranial pressure (ICP)) owing to an unexplained cause. It affects 1:100,000 persons yearly with a 20 times greater prevalence in young, obese girls. We wanted to correlate between optical coherence tomography ganglion cell layer analyses and visual field in patients of benign intracranial hypertension. Methods: This cross-sectional clinical study that was carried out on 30 patients (60 eyes) who all had a recently diagnosed papilledema due to first episode of IIH. Goal of the study, and applied tests was done before obtaining an informed consent. Personal history, past medical and ocular history, possible risk factors for IIH were taken. Full ophthalmological examination including best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, pupillary reflexes, slit lamp bio microscopy examination including assessment of papilledema grade, blood pressure check and body mass index (BMI). All patients underwent automated perimetry in dim light to evaluate their visual field using SITA fast Standard 30-2 protocol by Humphrey Field Analyzer (Humphrey Field Analyzer I Carl Zeiss AG – Oberkochen – Germany). Results: Average RNFL thickness had significant positive correlation with rim area (r=0.654, P<0.001) and disc area (r=0.665, P<0.001). Average RNFL thickness had no correlation with VA, IOP and average CD. Average GCL complex had significant negative correlation with rim area (r= -0.283, P=0.028) and disc area (r= -0.328, P=0.01). Average GCL complex had no correlation with VA, IOP and average CD. Minimum GCL complex had significant negative correlation with rim area (r= -0.272, P=0.036) and disc area (r= -0.315, P=0.014). Minimum GCL complex had no correlation with VA, IOP and average CD. Papilledema grading had significant positive correlation with average RNFL thickness (r=0.461, P<0.001). Papilledema grading had no correlation with average GCL complex, minimum GCL complex, VFI, MD and PSD. Conclusions: There is a strong structure-function link between visual field indices and OCT parameters such as RNFL and GCC.
背景：良性颅内高压症（BIH）是指由于不明原因导致环绕大脑和脊髓的蛛网膜下腔中的脑脊液（CSF）压力过高（ICP）。这种疾病每年的发病率为 1:100,000，而年轻肥胖女孩的发病率要高出 20 倍。我们希望将光学相干断层扫描神经节细胞层分析与良性颅内高压患者的视野相关联。研究方法这项横断面临床研究的对象是 30 名患者（60 只眼），他们都因首次颅内高压发作而在最近被诊断为乳头水肿。在获得知情同意之前，先进行研究目标和应用测试。了解个人病史、既往病史和眼科病史，以及 IIH 可能的危险因素。全面的眼科检查包括最佳矫正视力（BCVA）、眼压（IOP）、色觉、瞳孔反射、裂隙灯生物显微镜检查（包括乳头水肿等级评估）、血压检查和体重指数（BMI）。所有患者都在昏暗的光线下接受了自动周边测量，通过汉弗莱视野分析仪（Humphrey Field Analyzer I Carl Zeiss AG - Oberkochen - Germany）使用 SITA 快速标准 30-2 方案评估视野。结果平均 RNFL 厚度与边缘面积（r=0.654，P<0.001）和视盘面积（r=0.665，P<0.001）呈显著正相关。平均 RNFL 厚度与视力、眼压和平均 CD 没有相关性。 平均 GCL 复层与边缘面积（r= -0.283，P=0.028）和视盘面积（r= -0.328，P=0.01）呈显著负相关。平均 GCL 复合物与 VA、IOP 和平均 CD 没有相关性。最小 GCL 复合物与边缘面积（r= -0.272，P=0.036）和视盘面积（r= -0.315，P=0.014）呈显著负相关。最小 GCL 复合物与 VA、IOP 和平均 CD 没有相关性。乳头水肿分级与平均 RNFL 厚度呈显著正相关（r=0.461，P<0.001）。乳头水肿分级与平均 GCL 复层、最小 GCL 复层、VFI、MD 和 PSD 无关。结论视野指数和 OCT 参数（如 RNFL 和 GCC）之间存在紧密的结构-功能联系。
{"title":"Correlation between Optical Coherence Tomography Ganglion Cell Layer Analysis and Visual Field in Cases of Benign Intracranial Hypertension","authors":"Elham Abdullah Elsheraiy Saad, Tarek Ragaey Mohammed, Rabab Mohammed El Soht, Tamer I Abdelhalim","doi":"10.9734/jammr/2024/v36i25366","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25366","url":null,"abstract":"Background: Benign intracranial hypertension (BIH) is a condition in which there is excessive cerebral spinal fluid (CSF) pressure in the subarachnoid space that surrounds the brain and spinal cord (intracranial pressure (ICP)) owing to an unexplained cause. It affects 1:100,000 persons yearly with a 20 times greater prevalence in young, obese girls. We wanted to correlate between optical coherence tomography ganglion cell layer analyses and visual field in patients of benign intracranial hypertension. \u0000Methods: This cross-sectional clinical study that was carried out on 30 patients (60 eyes) who all had a recently diagnosed papilledema due to first episode of IIH. Goal of the study, and applied tests was done before obtaining an informed consent. Personal history, past medical and ocular history, possible risk factors for IIH were taken. Full ophthalmological examination including best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, pupillary reflexes, slit lamp bio microscopy examination including assessment of papilledema grade, blood pressure check and body mass index (BMI). All patients underwent automated perimetry in dim light to evaluate their visual field using SITA fast Standard 30-2 protocol by Humphrey Field Analyzer (Humphrey Field Analyzer I Carl Zeiss AG – Oberkochen – Germany). \u0000Results: Average RNFL thickness had significant positive correlation with rim area (r=0.654, P<0.001) and disc area (r=0.665, P<0.001). Average RNFL thickness had no correlation with VA, IOP and average CD. \u0000 Average GCL complex had significant negative correlation with rim area (r= -0.283, P=0.028) and disc area (r= -0.328, P=0.01). Average GCL complex had no correlation with VA, IOP and average CD. Minimum GCL complex had significant negative correlation with rim area (r= -0.272, P=0.036) and disc area (r= -0.315, P=0.014). Minimum GCL complex had no correlation with VA, IOP and average CD. Papilledema grading had significant positive correlation with average RNFL thickness (r=0.461, P<0.001). Papilledema grading had no correlation with average GCL complex, minimum GCL complex, VFI, MD and PSD. \u0000Conclusions: There is a strong structure-function link between visual field indices and OCT parameters such as RNFL and GCC.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139786813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-10DOI: 10.9734/jammr/2024/v36i25366
Elham Abdullah Elsheraiy Saad, Tarek Ragaey Mohammed, Rabab Mohammed El Soht, Tamer I Abdelhalim
Background: Benign intracranial hypertension (BIH) is a condition in which there is excessive cerebral spinal fluid (CSF) pressure in the subarachnoid space that surrounds the brain and spinal cord (intracranial pressure (ICP)) owing to an unexplained cause. It affects 1:100,000 persons yearly with a 20 times greater prevalence in young, obese girls. We wanted to correlate between optical coherence tomography ganglion cell layer analyses and visual field in patients of benign intracranial hypertension. Methods: This cross-sectional clinical study that was carried out on 30 patients (60 eyes) who all had a recently diagnosed papilledema due to first episode of IIH. Goal of the study, and applied tests was done before obtaining an informed consent. Personal history, past medical and ocular history, possible risk factors for IIH were taken. Full ophthalmological examination including best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, pupillary reflexes, slit lamp bio microscopy examination including assessment of papilledema grade, blood pressure check and body mass index (BMI). All patients underwent automated perimetry in dim light to evaluate their visual field using SITA fast Standard 30-2 protocol by Humphrey Field Analyzer (Humphrey Field Analyzer I Carl Zeiss AG – Oberkochen – Germany). Results: Average RNFL thickness had significant positive correlation with rim area (r=0.654, P<0.001) and disc area (r=0.665, P<0.001). Average RNFL thickness had no correlation with VA, IOP and average CD. Average GCL complex had significant negative correlation with rim area (r= -0.283, P=0.028) and disc area (r= -0.328, P=0.01). Average GCL complex had no correlation with VA, IOP and average CD. Minimum GCL complex had significant negative correlation with rim area (r= -0.272, P=0.036) and disc area (r= -0.315, P=0.014). Minimum GCL complex had no correlation with VA, IOP and average CD. Papilledema grading had significant positive correlation with average RNFL thickness (r=0.461, P<0.001). Papilledema grading had no correlation with average GCL complex, minimum GCL complex, VFI, MD and PSD. Conclusions: There is a strong structure-function link between visual field indices and OCT parameters such as RNFL and GCC.
背景：良性颅内高压症（BIH）是指由于不明原因导致环绕大脑和脊髓的蛛网膜下腔中的脑脊液（CSF）压力过高（ICP）。这种疾病每年的发病率为 1:100,000，而年轻肥胖女孩的发病率要高出 20 倍。我们希望将光学相干断层扫描神经节细胞层分析与良性颅内高压患者的视野相关联。研究方法这项横断面临床研究的对象是 30 名患者（60 只眼），他们都因首次颅内高压发作而在最近被诊断为乳头水肿。在获得知情同意之前，先进行研究目标和应用测试。了解个人病史、既往病史和眼科病史，以及 IIH 可能的危险因素。全面的眼科检查包括最佳矫正视力（BCVA）、眼压（IOP）、色觉、瞳孔反射、裂隙灯生物显微镜检查（包括乳头水肿等级评估）、血压检查和体重指数（BMI）。所有患者都在昏暗的光线下接受了自动周边测量，通过汉弗莱视野分析仪（Humphrey Field Analyzer I Carl Zeiss AG - Oberkochen - Germany）使用 SITA 快速标准 30-2 方案评估视野。结果平均 RNFL 厚度与边缘面积（r=0.654，P<0.001）和视盘面积（r=0.665，P<0.001）呈显著正相关。平均 RNFL 厚度与视力、眼压和平均 CD 没有相关性。 平均 GCL 复层与边缘面积（r= -0.283，P=0.028）和视盘面积（r= -0.328，P=0.01）呈显著负相关。平均 GCL 复合物与 VA、IOP 和平均 CD 没有相关性。最小 GCL 复合物与边缘面积（r= -0.272，P=0.036）和视盘面积（r= -0.315，P=0.014）呈显著负相关。最小 GCL 复合物与 VA、IOP 和平均 CD 没有相关性。乳头水肿分级与平均 RNFL 厚度呈显著正相关（r=0.461，P<0.001）。乳头水肿分级与平均 GCL 复层、最小 GCL 复层、VFI、MD 和 PSD 无关。结论视野指数和 OCT 参数（如 RNFL 和 GCC）之间存在紧密的结构-功能联系。
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