Oral Lichenoid Reaction (OLR) is a chronic inflammatory lesion of the oral mucosa that occurs as an allergic response to certain dental materials, medications and systemic diseases. The frequency of OLR in the general population has been documented to be very less. The clinical and histological features of OLR closely resemble those of Oral Lichen Planus (OLP), making it challenging to distinguish between the two clinically. OLRs might have a higher malignant potential than OLP. The diagnosis and treatment of OLR is very crucial as misdiagnosis may result in detrimental effects on the biophysical health of the patient. Here, we present case series of two patients who presented with amalgam restorations and burning sensation on the buccal mucosa while consumption of hot and spicy food. An immunohistopathological evaluation confirmed the diagnosis as Oral Lichenoid Reaction. Elimination of causative factors remain the mainstay of treatment which markedly reduces the sufferings of the patient with a commendable result.
{"title":"A Burning Issue on Oral Mucosal Diseases: Case Series with Review","authors":"Durba Roychowdhury, Rudra Prasad Chatterjee, S. Mahmud, Sudeshna Bagchi, Arunit Chatterjee","doi":"10.9734/jammr/2024/v36i85528","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85528","url":null,"abstract":"Oral Lichenoid Reaction (OLR) is a chronic inflammatory lesion of the oral mucosa that occurs as an allergic response to certain dental materials, medications and systemic diseases. The frequency of OLR in the general population has been documented to be very less. The clinical and histological features of OLR closely resemble those of Oral Lichen Planus (OLP), making it challenging to distinguish between the two clinically. OLRs might have a higher malignant potential than OLP. The diagnosis and treatment of OLR is very crucial as misdiagnosis may result in detrimental effects on the biophysical health of the patient. Here, we present case series of two patients who presented with amalgam restorations and burning sensation on the buccal mucosa while consumption of hot and spicy food. An immunohistopathological evaluation confirmed the diagnosis as Oral Lichenoid Reaction. Elimination of causative factors remain the mainstay of treatment which markedly reduces the sufferings of the patient with a commendable result.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"65 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.9734/jammr/2024/v36i85527
Shazain Khan, Raheel Chaudhry, Arhum Mahmood, M. Masmoum, Shaf A. Altaf, M. S. S. Mirza
Myocardial infarction (MI), often known as a heart attack, is a severe form of coronary artery disease that causes myocardial damage or necrosis as a result of persistent ischemia. Hypertension, atherosclerosis, diabetes, hyperlipidemia, smoking, lack of physical activity, and obesity are all significant risk factors. Recognizing symptoms such as chest pain, shortness of breath, heavy perspiration, and nausea is crucial for timely treatment. Advances in high-sensitivity troponin tests, coronary angiography, percutaneous coronary intervention (PCI), and pharmaceutical therapies, such as antiplatelet medications, beta-blockers, and statins, have all improved patient outcomes. The reduction of MI morbidity and mortality is contingent on early detection, prompt intervention, and ongoing care. This comprehensive study underlines the need to identify MI symptoms early and call emergency medical services to improve patient outcomes. Emerging medicines and future tactics in MI therapy, including novel antiplatelet agents and precision medicine approaches, hold promise for enhancing patient care.
{"title":"Myocardial Infarction: Causes, Symptoms, and Emergency Response","authors":"Shazain Khan, Raheel Chaudhry, Arhum Mahmood, M. Masmoum, Shaf A. Altaf, M. S. S. Mirza","doi":"10.9734/jammr/2024/v36i85527","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85527","url":null,"abstract":"Myocardial infarction (MI), often known as a heart attack, is a severe form of coronary artery disease that causes myocardial damage or necrosis as a result of persistent ischemia. Hypertension, atherosclerosis, diabetes, hyperlipidemia, smoking, lack of physical activity, and obesity are all significant risk factors. Recognizing symptoms such as chest pain, shortness of breath, heavy perspiration, and nausea is crucial for timely treatment. Advances in high-sensitivity troponin tests, coronary angiography, percutaneous coronary intervention (PCI), and pharmaceutical therapies, such as antiplatelet medications, beta-blockers, and statins, have all improved patient outcomes. The reduction of MI morbidity and mortality is contingent on early detection, prompt intervention, and ongoing care. This comprehensive study underlines the need to identify MI symptoms early and call emergency medical services to improve patient outcomes. Emerging medicines and future tactics in MI therapy, including novel antiplatelet agents and precision medicine approaches, hold promise for enhancing patient care.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"58 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.9734/jammr/2024/v36i85526
David Saldanha de Brito Alencar, Larissa Carvalho Novaes Batista, Jaqueline Martins Crivelari, Andre Luiz Almeida de Abreu, Anna Carolina Neves Leutz, Arian Braido, Leandro Ferreira Frade Soares, Bruno Martini Guimarães, M. Marciano
Aims: The propose of this study was to evaluate, using spectrophotometric analysis, the change in tooth color induced by different calcium silicate-based sealers over the period of 24 hours and 30 days. Methodology: Sixty bovine teeth were sectioned in enamel-dentin blocks. They were filled with AH Plus Bioceramic, AH Plus Jet, Bio-C Sealer and BioRoot RCS and sealed with composite. Triple antibiotic paste and unfilled samples were positive and negative control groups, respectively. Specimens were stored in separate flasks immersed in tap water at 37ºC with ambient light block out. Spectrophotometric analysis for color assessment was performed at different periods, before filling, 24 hours, and 30 days after filling. Luminosity (L) and color change ( ) were calculated. The statistical analysis was performed by using ANOVA and Tukey’s test (P < 0.05). Results: All calcium silicate-based sealers exhibited high color alteration after the evaluated period of 30 days and showed statistically significant difference values of in relation with the negative control in the period of 30 days (P < 0.05). Luminosity was not affected in comparison with negative control, in both evaluated periods (P < 0.05). Conclusion: All tested sealers showed certain levels of tooth discoloration. Calcium silicate-based sealers (AH Plus Bioceramic, Bio-C Sealer, and BioRoot RCS) presented discoloration exceeding acceptable values within a 30-day follow-up. Notwithstanding, these alterations were imperceptible to the human eye.
{"title":"Tooth Discoloration Induced by Calcium Silicate-based Sealers","authors":"David Saldanha de Brito Alencar, Larissa Carvalho Novaes Batista, Jaqueline Martins Crivelari, Andre Luiz Almeida de Abreu, Anna Carolina Neves Leutz, Arian Braido, Leandro Ferreira Frade Soares, Bruno Martini Guimarães, M. Marciano","doi":"10.9734/jammr/2024/v36i85526","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85526","url":null,"abstract":"Aims: The propose of this study was to evaluate, using spectrophotometric analysis, the change in tooth color induced by different calcium silicate-based sealers over the period of 24 hours and 30 days. \u0000Methodology: Sixty bovine teeth were sectioned in enamel-dentin blocks. They were filled with AH Plus Bioceramic, AH Plus Jet, Bio-C Sealer and BioRoot RCS and sealed with composite. Triple antibiotic paste and unfilled samples were positive and negative control groups, respectively. Specimens were stored in separate flasks immersed in tap water at 37ºC with ambient light block out. Spectrophotometric analysis for color assessment was performed at different periods, before filling, 24 hours, and 30 days after filling. Luminosity (L) and color change ( ) were calculated. The statistical analysis was performed by using ANOVA and Tukey’s test (P < 0.05). \u0000Results: All calcium silicate-based sealers exhibited high color alteration after the evaluated period of 30 days and showed statistically significant difference values of in relation with the negative control in the period of 30 days (P < 0.05). Luminosity was not affected in comparison with negative control, in both evaluated periods (P < 0.05). \u0000Conclusion: All tested sealers showed certain levels of tooth discoloration. Calcium silicate-based sealers (AH Plus Bioceramic, Bio-C Sealer, and BioRoot RCS) presented discoloration exceeding acceptable values within a 30-day follow-up. Notwithstanding, these alterations were imperceptible to the human eye.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.9734/jammr/2024/v36i85524
Kirolos Alqus Sela Youssef Khalifa
Introduction: Tapentadol, a μ-opioid agonist and norepinephrine reuptake inhibitor is an effective medication for a wide variety of chronic pain conditions, including back pain, cancer-related pain, and arthritic pain. More recently, tapentadol extended-release has been demonstrated to be effective in the management of painful diabetic neuropathy, an often debilitating condition affecting approximately one-third of all patients with diabetes. Aim of the Study: To identify the efficacy of Tapentadol in the management of patients with Diabetic Neuropathic Pain and to compare the safety of Tapentadol with other drugs used in the management of diabetic neuropathy. Materials and Methods: Up to March 2023, PubMed, Cochrane CENTRAL, Web of Science, and Scopus were searched for potentially relevant studies that met the inclusion criteria. We adhered to PRISMA checklist items for reporting systematic reviews. Results: Three studies included 731 patients suffering from Diabetic polyneuropathy with a mean age of 60.9 years and a mean follow-up duration of 9.3 weeks. The mean difference between the Tapentadol and placebo is 0.97(95% CI [0.59, 1.34]) with the results in favour of Tapentadol with a total sample of 374 patients in the Tapentadol group and 357 patients in the Placebo group. Conclusion: Despite the efficacy of Tapentadol in PDN, the toxicity profile and higher incidence of withdrawal rate should give attention away its use in future research.
{"title":"Effectiveness and Safety of Tapentadol in Managing Diabetic Neuropathic Pain: A Systematic Review","authors":"Kirolos Alqus Sela Youssef Khalifa","doi":"10.9734/jammr/2024/v36i85524","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85524","url":null,"abstract":"Introduction: Tapentadol, a μ-opioid agonist and norepinephrine reuptake inhibitor is an effective medication for a wide variety of chronic pain conditions, including back pain, cancer-related pain, and arthritic pain. More recently, tapentadol extended-release has been demonstrated to be effective in the management of painful diabetic neuropathy, an often debilitating condition affecting approximately one-third of all patients with diabetes. \u0000Aim of the Study: To identify the efficacy of Tapentadol in the management of patients with Diabetic Neuropathic Pain and to compare the safety of Tapentadol with other drugs used in the management of diabetic neuropathy. \u0000Materials and Methods: Up to March 2023, PubMed, Cochrane CENTRAL, Web of Science, and Scopus were searched for potentially relevant studies that met the inclusion criteria. We adhered to PRISMA checklist items for reporting systematic reviews. \u0000Results: Three studies included 731 patients suffering from Diabetic polyneuropathy with a mean age of 60.9 years and a mean follow-up duration of 9.3 weeks. The mean difference between the Tapentadol and placebo is 0.97(95% CI [0.59, 1.34]) with the results in favour of Tapentadol with a total sample of 374 patients in the Tapentadol group and 357 patients in the Placebo group. \u0000Conclusion: Despite the efficacy of Tapentadol in PDN, the toxicity profile and higher incidence of withdrawal rate should give attention away its use in future research.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"83 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.9734/jammr/2024/v36i85525
I. Folorunsho, N. M. Harry, Chukwubueze Obiajunwa, Oluwatosin Arubuolawe, A. K. Busari, Chidalu N Ibeneme, Gibson Anugwom
Post-Traumatic Stress Disorder (PTSD) is a debilitating mental health condition that can occur after experiencing or witnessing a traumatic event. The impact of PTSD extends beyond the individual, affecting families, communities, and society as a whole. This study aims to investigate the potential of psilocybin as a treatment for PTSD. Psilocybin, after being metabolized to psilocin, binds to various serotonergic receptors to exert some major effects such as a reduction in negative mood and an increase in optimism, enhanced ability for introspection and perceptual changes, a reduction in amygdala reactivity during emotion processing, and—as has been found in animal studies—an extinction of the fear response and increased hippocampal neurogenesis. However, psychedelics such as psilocybin may lead to brief episodes of nausea, vomiting, and physical discomfort. This study indicated that there is an urgent need for innovative therapies that could enhance the effectiveness of PTSD treatments. As this review highlights, psilocybin and some other psychedelics offer prospects for an additional method of treating PTSD. They have the potential to directly address PTSD symptoms and can also be used as an adjunct to psychotherapy.
{"title":"PTSD Treatment: An Inquiry into the Promising Potential of Psilocybin","authors":"I. Folorunsho, N. M. Harry, Chukwubueze Obiajunwa, Oluwatosin Arubuolawe, A. K. Busari, Chidalu N Ibeneme, Gibson Anugwom","doi":"10.9734/jammr/2024/v36i85525","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85525","url":null,"abstract":"Post-Traumatic Stress Disorder (PTSD) is a debilitating mental health condition that can occur after experiencing or witnessing a traumatic event. The impact of PTSD extends beyond the individual, affecting families, communities, and society as a whole. This study aims to investigate the potential of psilocybin as a treatment for PTSD. Psilocybin, after being metabolized to psilocin, binds to various serotonergic receptors to exert some major effects such as a reduction in negative mood and an increase in optimism, enhanced ability for introspection and perceptual changes, a reduction in amygdala reactivity during emotion processing, and—as has been found in animal studies—an extinction of the fear response and increased hippocampal neurogenesis. However, psychedelics such as psilocybin may lead to brief episodes of nausea, vomiting, and physical discomfort. This study indicated that there is an urgent need for innovative therapies that could enhance the effectiveness of PTSD treatments. As this review highlights, psilocybin and some other psychedelics offer prospects for an additional method of treating PTSD. They have the potential to directly address PTSD symptoms and can also be used as an adjunct to psychotherapy.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"42 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-23DOI: 10.9734/jammr/2024/v36i85521
Vincent Musungu, Domnic Marera, W. Oyieko, Wilbroda Makunda, Benard Siwa
Background: Men are more likely to develop prostate lesions like benign prostatic hypertrophy and prostate cancer as they age. Prostate specific antigen (PSA), which is secreted in large quantities above normal levels of 0–4 ng/ml by cells of the prostate gland in benign prostate hypertrophy (BPH) or prostate cancer (Pca), is a biological marker for the diagnosis of prostate cancer; hence, early diagnosis using PSA facilitates disease detection; the higher the level of PSA, the higher the chance of having prostate cancer (Negahdary et al., 2020; Zhang & Sun, 2018). The Gleason scale is used to grade patients with prostate cancer and determine their risk of the disease progressing. Is it possible to predict the Gleason scores of people with prostate cancer based on their PSA levels? The primary goal of the current study was to establish a correlation between the patient's PSA level and the associated Gleason scores at the time of prostate biopsy at Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH). Methods: The study utilized a cross-sectional retrospective that focused on patient reports with prostate histology who had a PSA between 2017 and 2022 when they requested a biopsy. The majority of the examined histology reports that did not include a PSA level and thus were disregarded. There were 80 sample reports as a result of this exclusion. Results: According to the study, 36 (45%) of the patients whose prostate tissues were examined had prostate cancer. The majority of 24 (66.7%) patients who had PSA values more than 50 ng/ml when they were first diagnosed with prostate cancer were classified as Gleason 7/Group 2 or higher. The study sought to determine whether PSA levels and Gleason scores were correlated. Gleason scores and PSA levels have a statistically significant positive correlation (p = 0.004, r = 0.474). The majority of patients, 55 (65%), who had high PSA values (>4 ng/ml), were between the ages of 60 and 79. These patients were followed by those who were >80 years old at 15 (18.75%) and those who were 50 to 59 years old at 10 (10%). Age and PSA levels were shown to have a statistically significant positive Pearson correlation (r = 0.236, p = 0.035, 95% CI). Conclusions: Gleason scores rise with increasing PSA levels. Age and PSA level have a positive correlation.
{"title":"Using Prostate-specific Antigen to Predict Gleason Scores in African Men Seeking Urological Services at a Referral Hospital in Kisumu, Kenya","authors":"Vincent Musungu, Domnic Marera, W. Oyieko, Wilbroda Makunda, Benard Siwa","doi":"10.9734/jammr/2024/v36i85521","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85521","url":null,"abstract":"Background: Men are more likely to develop prostate lesions like benign prostatic hypertrophy and prostate cancer as they age. Prostate specific antigen (PSA), which is secreted in large quantities above normal levels of 0–4 ng/ml by cells of the prostate gland in benign prostate hypertrophy (BPH) or prostate cancer (Pca), is a biological marker for the diagnosis of prostate cancer; hence, early diagnosis using PSA facilitates disease detection; the higher the level of PSA, the higher the chance of having prostate cancer (Negahdary et al., 2020; Zhang & Sun, 2018). The Gleason scale is used to grade patients with prostate cancer and determine their risk of the disease progressing. Is it possible to predict the Gleason scores of people with prostate cancer based on their PSA levels? The primary goal of the current study was to establish a correlation between the patient's PSA level and the associated Gleason scores at the time of prostate biopsy at Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH). \u0000Methods: The study utilized a cross-sectional retrospective that focused on patient reports with prostate histology who had a PSA between 2017 and 2022 when they requested a biopsy. The majority of the examined histology reports that did not include a PSA level and thus were disregarded. There were 80 sample reports as a result of this exclusion. \u0000Results: According to the study, 36 (45%) of the patients whose prostate tissues were examined had prostate cancer. The majority of 24 (66.7%) patients who had PSA values more than 50 ng/ml when they were first diagnosed with prostate cancer were classified as Gleason 7/Group 2 or higher. The study sought to determine whether PSA levels and Gleason scores were correlated. Gleason scores and PSA levels have a statistically significant positive correlation (p = 0.004, r = 0.474). The majority of patients, 55 (65%), who had high PSA values (>4 ng/ml), were between the ages of 60 and 79. These patients were followed by those who were >80 years old at 15 (18.75%) and those who were 50 to 59 years old at 10 (10%). Age and PSA levels were shown to have a statistically significant positive Pearson correlation (r = 0.236, p = 0.035, 95% CI). \u0000Conclusions: Gleason scores rise with increasing PSA levels. Age and PSA level have a positive correlation.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"53 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-23DOI: 10.9734/jammr/2024/v36i85522
Shaheen Sultana, Kayode Aguda, Adetola G Mowo-wale, Regina Azipu, Chiedozie Steven Nzotta, S. Alzaki, Marian Obi, Onyinye Ezewudo, Abdelhay Hassan Taha Mohamed, Shwetha Gopal, Tope Mwuese Anyiman, N. G. Obiefuna, Efi Uyoyou Winners, Omolola Okunromade, Prince Agbakahi, Jovita Echere
Background: Hypertension is a global health challenge, affecting over a billion individuals worldwide. Despite the availability of effective treatments, control rates remain suboptimal. Emerging technologies, such as smartphone applications, offer new avenues to enhance hypertension management. This systematic review aims to evaluate the effectiveness of smartphone applications in hypertension management. Methods: To provide a comprehensive overview of the current evidence, we systematically searched PubMed, EMBASE, and the Cochrane Library for both randomized controlled trials (RCTs) and non-randomized clinical trials that examined the use of smartphone applications in hypertension management. Our search included all relevant studies published until June 2023. Studies were selected based on predefined criteria relating to study design, patient population, intervention type, and outcome measures. Data were extracted and analyzed by two independent reviewers. The primary outcome of interest was blood pressure control, while secondary outcomes included medication adherence and health-related knowledge. Results: From our systematic search, a total of 11 RCTs involving 1,685 participants met our inclusion criteria and were included in the review. The smartphone-based interventions varied widely across studies, ranging from simple text reminders to comprehensive digital therapeutics systems, and including education-based applications, self-monitoring programs, and telemonitoring systems. Collectively, these interventions demonstrated significant improvements in blood pressure control in the intervention groups compared to the standard care. Additionally, they showed increased medication adherence and enhanced health-related knowledge, suggesting potential benefits beyond blood pressure control. Conclusion: The reviewed studies suggest that smartphone applications may provide a beneficial tool for managing hypertension. They show improvements in blood pressure control, medication adherence, and health-related knowledge. These findings underline the potential of digital health interventions to address a global health concern. Nevertheless, further robust, well-designed RCTs are needed to corroborate these findings and explore the long-term effectiveness, sustainability, and cost-effectiveness of smartphone applications in hypertension management. With the rapid advancement in technology, the role of digital health in hypertension management is likely to become even more critical and complex, making this an area of crucial importance for future research.
{"title":"Efficacy of Smartphone Applications in Hypertension Management: A Systematic Review","authors":"Shaheen Sultana, Kayode Aguda, Adetola G Mowo-wale, Regina Azipu, Chiedozie Steven Nzotta, S. Alzaki, Marian Obi, Onyinye Ezewudo, Abdelhay Hassan Taha Mohamed, Shwetha Gopal, Tope Mwuese Anyiman, N. G. Obiefuna, Efi Uyoyou Winners, Omolola Okunromade, Prince Agbakahi, Jovita Echere","doi":"10.9734/jammr/2024/v36i85522","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85522","url":null,"abstract":"Background: Hypertension is a global health challenge, affecting over a billion individuals worldwide. Despite the availability of effective treatments, control rates remain suboptimal. Emerging technologies, such as smartphone applications, offer new avenues to enhance hypertension management. This systematic review aims to evaluate the effectiveness of smartphone applications in hypertension management. \u0000Methods: To provide a comprehensive overview of the current evidence, we systematically searched PubMed, EMBASE, and the Cochrane Library for both randomized controlled trials (RCTs) and non-randomized clinical trials that examined the use of smartphone applications in hypertension management. Our search included all relevant studies published until June 2023. Studies were selected based on predefined criteria relating to study design, patient population, intervention type, and outcome measures. Data were extracted and analyzed by two independent reviewers. The primary outcome of interest was blood pressure control, while secondary outcomes included medication adherence and health-related knowledge. \u0000Results: From our systematic search, a total of 11 RCTs involving 1,685 participants met our inclusion criteria and were included in the review. The smartphone-based interventions varied widely across studies, ranging from simple text reminders to comprehensive digital therapeutics systems, and including education-based applications, self-monitoring programs, and telemonitoring systems. Collectively, these interventions demonstrated significant improvements in blood pressure control in the intervention groups compared to the standard care. Additionally, they showed increased medication adherence and enhanced health-related knowledge, suggesting potential benefits beyond blood pressure control. \u0000Conclusion: The reviewed studies suggest that smartphone applications may provide a beneficial tool for managing hypertension. They show improvements in blood pressure control, medication adherence, and health-related knowledge. These findings underline the potential of digital health interventions to address a global health concern. Nevertheless, further robust, well-designed RCTs are needed to corroborate these findings and explore the long-term effectiveness, sustainability, and cost-effectiveness of smartphone applications in hypertension management. With the rapid advancement in technology, the role of digital health in hypertension management is likely to become even more critical and complex, making this an area of crucial importance for future research.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"55 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-23DOI: 10.9734/jammr/2024/v36i85523
A. Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães, B. M. Mangiavacchi, Ligia Cordeiro Matos Faial, Ivy de Campos, Renato Mataveli Ferreira Filho, Alcemar Antônio Lopes de Matos, Kelen Salaroli Viana, Júlio Cesar dos Santos Boechat, Juliana Toledo Campos Arêas
Background and Aim: Prototheca is a genus of unicellular, non-photosynthetic microalgae found in diverse environments, including water, soil, and the intestinal microbiota of animals and humans. They are the only algae pathogenic to humans. Infections of the Central Nervous System (CNS) by Prototheca spp. are rare but severe. This research aims to systematically review the pathogenic potential of Prototheca spp. as CNS infectious agents in humans, identify underlying conditions that contribute to disease development, and evaluate the most suitable drug therapy alternatives for this clinical condition. Methods: A systematic review was conducted using PubMed, SciELO, and Google Scholar databases. Search terms included "Prototheca," "Central Nervous System," "meningitis," "encephalitis," "meningoencephalitis," and "brain." Manuscripts published in English, Portuguese, Spanish, and Russian from 1981 to 2024 were reviewed. Results: The review identified 15 case reports of CNS infections by Prototheca spp. described in 14 scientific articles. Three species were implicated: Prototheca wickerhamii, Prototheca zopfii, and Prototheca trispora, with Prototheca wickerhamii being the most prevalent (66.6%). Only four patients were immunocompromised. A significant association was found between hydrocephalus in children and vulnerability to CNS protothecosis, accounting for 20% of cases. All fatal cases occurred in immunocompromised patients. Resistance profile analysis showed 88.9% susceptibility to amphotericin B and susceptibility to two triazoles (voriconazole and isavuconazole) that cross the blood-brain barrier. Conclusion: Immunodeficiency is not a prerequisite for susceptibility to CNS infections by Prototheca spp., but it predicts an unfavorable prognosis. The most promising treatments are combinations of amphotericin B with tetracyclines or isavuconazole. Dosage adjustments are necessary due to the toxicity of long-term algicidal antifungal treatments, posing a challenge in managing drug therapy.
背景和目的:原生藻是一种单细胞、非光合微藻,存在于水、土壤、动物和人类肠道微生物群等多种环境中。它们是唯一对人类致病的藻类。中枢神经系统(CNS)受原壶藻属感染的情况非常罕见,但却很严重。本研究旨在系统回顾原生藻类作为中枢神经系统感染病原体对人类的致病性,找出导致疾病发展的潜在因素,并评估最适合这一临床症状的药物疗法。方法:使用 PubMed、SciELO 和 Google Scholar 数据库进行系统性综述。搜索关键词包括 "原虫"、"中枢神经系统"、"脑膜炎"、"脑炎"、"脑膜脑炎 "和 "大脑"。对 1981 年至 2024 年用英语、葡萄牙语、西班牙语和俄语发表的文章进行了审查。结果:审查发现了 14 篇科学文章中描述的 15 例原虫感染中枢神经系统的病例报告。其中涉及三个物种:柳叶原神马属、佐菲原神马属和三孢原神马属,其中柳叶原神马属最常见(66.6%)。只有四名患者免疫力低下。研究发现,儿童脑积水与中枢神经系统原壶菌病的易感性之间存在明显联系,占病例总数的20%。所有死亡病例均发生在免疫力低下的患者身上。耐药性分析表明,88.9%的患者对两性霉素B敏感,并对可穿过血脑屏障的两种三唑类药物(伏立康唑和异武康唑)敏感。结论:免疫缺陷并不是原壶菌属中枢神经系统感染的先决条件,但它预示着不利的预后。最有希望的治疗方法是将两性霉素 B 与四环素类药物或异戊唑联合使用。由于长期的杀菌抗真菌治疗会产生毒性,因此有必要调整剂量,这给药物治疗的管理带来了挑战。
{"title":"A Systematic Review on Prototheca spp. Infections in the Human Central Nervous System and Evaluation of Therapeutic Drug Approaches","authors":"A. Norberg, Paulo Roberto Blanco Moreira Norberg, Fernanda Castro Manhães, B. M. Mangiavacchi, Ligia Cordeiro Matos Faial, Ivy de Campos, Renato Mataveli Ferreira Filho, Alcemar Antônio Lopes de Matos, Kelen Salaroli Viana, Júlio Cesar dos Santos Boechat, Juliana Toledo Campos Arêas","doi":"10.9734/jammr/2024/v36i85523","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i85523","url":null,"abstract":"Background and Aim: Prototheca is a genus of unicellular, non-photosynthetic microalgae found in diverse environments, including water, soil, and the intestinal microbiota of animals and humans. They are the only algae pathogenic to humans. Infections of the Central Nervous System (CNS) by Prototheca spp. are rare but severe. This research aims to systematically review the pathogenic potential of Prototheca spp. as CNS infectious agents in humans, identify underlying conditions that contribute to disease development, and evaluate the most suitable drug therapy alternatives for this clinical condition. \u0000Methods: A systematic review was conducted using PubMed, SciELO, and Google Scholar databases. Search terms included \"Prototheca,\" \"Central Nervous System,\" \"meningitis,\" \"encephalitis,\" \"meningoencephalitis,\" and \"brain.\" Manuscripts published in English, Portuguese, Spanish, and Russian from 1981 to 2024 were reviewed. \u0000Results: The review identified 15 case reports of CNS infections by Prototheca spp. described in 14 scientific articles. Three species were implicated: Prototheca wickerhamii, Prototheca zopfii, and Prototheca trispora, with Prototheca wickerhamii being the most prevalent (66.6%). Only four patients were immunocompromised. A significant association was found between hydrocephalus in children and vulnerability to CNS protothecosis, accounting for 20% of cases. All fatal cases occurred in immunocompromised patients. Resistance profile analysis showed 88.9% susceptibility to amphotericin B and susceptibility to two triazoles (voriconazole and isavuconazole) that cross the blood-brain barrier. \u0000Conclusion: Immunodeficiency is not a prerequisite for susceptibility to CNS infections by Prototheca spp., but it predicts an unfavorable prognosis. The most promising treatments are combinations of amphotericin B with tetracyclines or isavuconazole. Dosage adjustments are necessary due to the toxicity of long-term algicidal antifungal treatments, posing a challenge in managing drug therapy.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"132 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141811622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.9734/jammr/2024/v36i75520
R. Vanolli, A. M. Cavazzini, Gabriela Spanholi Tamagno, Poliana Maria de Faveri Cardoso, Júlio Katuhide Ueda, Veridiana Camilotti
Objective: To clinically evaluate for 24 months the restorations of caries-free cervical lesions (CFCL) made with bulk-fill composite resin. Materials and Methods: Sixty CFCL were selected and divided into two experimental groups: Filtek Z350 (control with conventional composite resin) and Filtek BF (Bulk Fill composite resin). The restorations were evaluated according to the USPHS criteria - marginal adaptation, anatomic form, marginal discoloration, caries formation, postoperative sensitivity, and retention - at the following periods: initial, 7, 30, 180, and 720 days. The results were statistically analyzed using the Friedman ANOVA test (p < 0.05) followed by the Durbin-Conover post-test (p < 0.05). For intra-group analysis, the Wilcoxon non-parametric test was used (p < 0.05). Results: Significant differences were observed between the groups, with Bulk Fill resin showing superior clinical performance in terms of marginal adaptation, restoration discoloration, anatomic form, and especially dentin sensitivity. Regarding caries formation and retention, both groups presented similar results. Conclusion: Bulk-fill composite resins demonstrated superiority in various USPHS criteria in the treatment of caries-free cervical lesions, proving to be a promising material for this treatment context.
{"title":"Bulk Fill Composite Resin for Non-carious Cervical Lesions: A 24-Month Randomized Clinical Study","authors":"R. Vanolli, A. M. Cavazzini, Gabriela Spanholi Tamagno, Poliana Maria de Faveri Cardoso, Júlio Katuhide Ueda, Veridiana Camilotti","doi":"10.9734/jammr/2024/v36i75520","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i75520","url":null,"abstract":"Objective: To clinically evaluate for 24 months the restorations of caries-free cervical lesions (CFCL) made with bulk-fill composite resin. \u0000Materials and Methods: Sixty CFCL were selected and divided into two experimental groups: Filtek Z350 (control with conventional composite resin) and Filtek BF (Bulk Fill composite resin). The restorations were evaluated according to the USPHS criteria - marginal adaptation, anatomic form, marginal discoloration, caries formation, postoperative sensitivity, and retention - at the following periods: initial, 7, 30, 180, and 720 days. The results were statistically analyzed using the Friedman ANOVA test (p < 0.05) followed by the Durbin-Conover post-test (p < 0.05). For intra-group analysis, the Wilcoxon non-parametric test was used (p < 0.05). \u0000Results: Significant differences were observed between the groups, with Bulk Fill resin showing superior clinical performance in terms of marginal adaptation, restoration discoloration, anatomic form, and especially dentin sensitivity. Regarding caries formation and retention, both groups presented similar results. \u0000Conclusion: Bulk-fill composite resins demonstrated superiority in various USPHS criteria in the treatment of caries-free cervical lesions, proving to be a promising material for this treatment context.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.9734/jammr/2024/v36i75518
Letícia Neves Mode, Cindy Mozer Nakamura, T. Cunha, Fernanda Cardoso Nakamoto, M. Leonardis, Cid André Fidelis de Paula Gomes, F. Politti, D. Biasotto-Gonzalez
Objective: To evaluate the effect of adding oculomotor exercises to the treatment of Temporomandibular Disorder (TMD) on pain intensity, range of mandibular movement, TMD severity, and ocular convergence insufficiency (CI), immediately, 3 months, and 6 months after treatment. Study Design: Controlled and randomized clinical trial included blinded evaluators and participants. Methodology: Individuals aged 18–45 years diagnosed with TMD and convergence insufficiency. Intervention: Two groups: the experimental group (EG) and the control group (CG) groups will receive 12 treatment sessions. Main outcome measures: pain intensity, range of mandibular movement, convergence insufficiency, and severity of TMD during follow-up immediately after treatment, 3 and 6 months. Analysis: The statistical analysis will use linear mixed models based on the intention to treat. The significance level will be set at 5%. Results: This is a preliminary protocol; results will be available once the study is completed. It is expected relevant patient clinical improvement results. Conclusion: It will be possible to determine the effects of adding oculomotor exercises in the treatment of TMD. Implications for Practice: If successful, the protocol could be integrated into clinical practice as an adjunct to conventional therapy for TMD, expanding the therapeutic options available to healthcare professionals and patients.
{"title":"Protocol for a Randomized Clinical Trial of Oculomotor Exercises Added to Treatment for Temporomandibular Disorders","authors":"Letícia Neves Mode, Cindy Mozer Nakamura, T. Cunha, Fernanda Cardoso Nakamoto, M. Leonardis, Cid André Fidelis de Paula Gomes, F. Politti, D. Biasotto-Gonzalez","doi":"10.9734/jammr/2024/v36i75518","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i75518","url":null,"abstract":"Objective: To evaluate the effect of adding oculomotor exercises to the treatment of Temporomandibular Disorder (TMD) on pain intensity, range of mandibular movement, TMD severity, and ocular convergence insufficiency (CI), immediately, 3 months, and 6 months after treatment. \u0000Study Design: Controlled and randomized clinical trial included blinded evaluators and participants. \u0000Methodology: Individuals aged 18–45 years diagnosed with TMD and convergence insufficiency. \u0000Intervention: Two groups: the experimental group (EG) and the control group (CG) groups will receive 12 treatment sessions. Main outcome measures: pain intensity, range of mandibular movement, convergence insufficiency, and severity of TMD during follow-up immediately after treatment, 3 and 6 months. \u0000Analysis: The statistical analysis will use linear mixed models based on the intention to treat. The significance level will be set at 5%. \u0000Results: This is a preliminary protocol; results will be available once the study is completed. It is expected relevant patient clinical improvement results. \u0000Conclusion: It will be possible to determine the effects of adding oculomotor exercises in the treatment of TMD. \u0000Implications for Practice: If successful, the protocol could be integrated into clinical practice as an adjunct to conventional therapy for TMD, expanding the therapeutic options available to healthcare professionals and patients.","PeriodicalId":506708,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"9 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141640518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}