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Make Your Opinion Known. 公开你的意见。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-12-01 DOI: 10.1097/WNN.0000000000000324
Barry Gordon
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引用次数: 0
The Account of the Effect of Switch Probability on Switch and Mixing Costs: An ERP Study in a Cued Task-switching Paradigm. 转换概率对转换和混合成本的影响:线索任务转换范式下的ERP研究。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-12-01 DOI: 10.1097/WNN.0000000000000317
Cheng Wenwen, Yan Yang, Liyan Cui, Ying Chen, Weiguo Zhang, Xiong Zhang, Shu Zhou

Background: Whether the effect of switch probability on switch and mixing costs is explained by an activation or preparation account is unclear.

Objective: To investigate the account of the effect of switch probability on switch and mixing costs.

Method: We used a cued task-switching paradigm with three switch probabilities (high, 75%; medium, 50%; and low, 25%) with 19 healthy young adults and recorded the cue- and target-locked event-related potentials (ERPs) and behavioral performance. The task included switch and stay trials under high, medium, and low switch conditions, as well as pure trials.

Results: There was no significant difference in reaction time (RT) in switch and mixing costs between the high and medium switch conditions. The RT in switch and mixing costs in the high and medium switch conditions was significantly less and more than in the low switch condition, respectively. The cue-locked ERPs revealed significant effects on mixing costs (stay - pure) that were cue early frontal positivity (260-300 ms) in the high and medium switch conditions, and on switch costs (switch - stay) that were cue early central positivity (240-260 ms) in the low switch condition. Moreover, the target-locked ERPs of the mixing costs revealed significant effects on mixing costs that were target P3b (440-540 ms) in all three switch conditions, and on switch costs that were target P3b in the medium and low switch conditions.

Conclusion: The effect of switch probability on switch and mixing costs is explained by the activation account.

背景:转换概率对转换和混合成本的影响是否可以通过激活或准备账户来解释尚不清楚。目的:探讨转换概率对转换成本和混合成本的影响。方法:我们对19名健康年轻人使用了三种切换概率(高,75%;中,50%;低,25%)的提示任务切换范式,并记录了提示和目标锁定事件相关电位(ERPs)和行为表现。该任务包括在高、中、低切换条件下的切换和停留试验,以及纯试验。结果:在高切换条件和中等切换条件下,切换反应时间(RT)和混合成本没有显著差异。高切换条件和中等切换条件下的RT切换和混合成本分别显著低于和高于低切换条件下。线索锁定的ERPs对混合成本(保持纯净)有显著影响,在高和中等切换条件下,混合成本是线索早期额叶阳性(260-300ms),对切换成本(切换-保持)有显著作用,在低切换条件下是线索早期中枢阳性(240-260ms)。此外,混合成本的目标锁定ERP显示出对在所有三种切换条件下为目标P3b(440-540ms)的混合成本以及对在中切换条件和低切换条件下的目标P3b的切换成本的显著影响。结论:转换概率对转换和混合成本的影响可以用激活账户来解释。
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引用次数: 0
Constructional Impairments and Their Neural Correlates in Nondemented Adults With Cerebral Autosomal-dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. 伴有皮质下梗死和白质脑病的大脑常染色体显性动脉病变的非痴呆成人的结构损伤及其神经相关性。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-12-01 DOI: 10.1097/WNN.0000000000000318
Natascia De Lucia, Michele Ragno, Cristina Paci, Gabriella Cacchiò, Anna Rita Caiazzo, Sara Tiberi, Anna De Rosa, Riccardo Navarra, Massimo Caulo, Giuseppe De Michele, Luigi Trojano

Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small-vessel disease that is characterized by a wide range of neurologic and neuropsychological impairments. Constructional impairments have been reported in some cases but have never been assessed systematically.

Objective: To evaluate constructional abilities and their cognitive and neural correlates in nondemented individuals with CADASIL.

Method: Thirty individuals with CADASIL who were not affected by clinically relevant cognitive deterioration and 30 healthy controls (HC) underwent an extensive cognitive assessment and paper-and-pencil visuoconstructional tasks in order to detect constructional impairments. Performance on the visuoconstructional tasks was correlated with the cognitive assessment scores and with quantitative indices of regional gray matter atrophy (obtained via FreeSurfer image analysis) and white matter involvement.

Results: The individuals with CADASIL achieved significantly lower scores on the cognitive assessment compared with the HC. Poor visuoconstructional abilities were observed in seven (23.3%) of the individuals with CADASIL when performing the copy drawing task and in nine (30%) when performing the Rey Complex Figure Test. Logistic regression revealed that visuoconstructional impairments were significantly associated with scores on the Frontal Assessment Battery and the Attentional Matrices Test. Morphometric results revealed that scores on the visuoconstructional tasks were related to gray matter atrophy of the left frontal lobe and right parietal lobe.

Conclusion: Impairments on visuoconstructional tasks are quite common in individuals with CADASIL, even in the lack of clinically relevant cognitive deterioration, and are critically related to frontal and parietal atrophy.

背景:伴有皮质下梗死和白质脑病的大脑常染色体显性遗传性动脉病(CADASIL)是一种单基因小血管疾病,其特征是广泛的神经和神经心理损伤。在某些情况下,曾报告过结构损伤,但从未进行过系统评估。目的:评估患有CADASIL的非痴呆患者的结构能力及其认知和神经相关性。方法:30名未受临床相关认知恶化影响的CADASIL患者和30名健康对照(HC)接受了广泛的认知评估和纸笔视觉结构任务,以检测结构减值。视觉结构任务的表现与认知评估得分以及区域灰质萎缩(通过FreeSurfer图像分析获得)和白质受累的定量指标相关。结果:与HC相比,患有CADASIL的个体在认知评估方面的得分显著较低。在进行复制绘图任务时,有7名(23.3%)CADASIL患者的视觉构造能力较差,在进行Rey复杂图形测试时,有9名(30%)患者的视觉结构能力较差。Logistic回归显示,视觉结构障碍与正面评估组和注意力矩阵测试的得分显著相关。形态计量学结果显示,视觉结构任务得分与左额叶和右顶叶灰质萎缩有关。结论:视觉结构任务障碍在CADASIL患者中非常常见,即使在没有临床相关认知恶化的情况下也是如此,并且与额顶叶萎缩密切相关。
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引用次数: 1
Memory Loss, Alzheimer's Disease, and Dementia: A Practical Guide for Clinicians, 3rd ed. 失忆、阿尔茨海默病和痴呆症:临床医生实用指南,第3版。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-12-01 DOI: 10.1097/WNN.0000000000000323
Howard S Kirshner
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引用次数: 3
The Swimmers: A Novel. 游泳者:一部小说。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-09-01 DOI: 10.1097/WNN.0000000000000315
Howard S Kirshner
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引用次数: 0
Validation of a Mobile, Sensor-based Neurobehavioral Assessment With Digital Signal Processing and Machine-learning Analytics. 通过数字信号处理和机器学习分析验证基于传感器的移动神经行为评估。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-09-01 DOI: 10.1097/WNN.0000000000000308
Kelly L Sloane, Joel A Mefford, Zilong Zhao, Man Xu, Guifeng Zhou, Rachel Fabian, Amy E Wright, Shenly Glenn

Background: The Miro Health Mobile Assessment Platform consists of self-administered neurobehavioral and cognitive assessments that measure behaviors typically measured by specialized clinicians.

Objective: To evaluate the Miro Health Mobile Assessment Platform's concurrent validity, test-retest reliability, and mild cognitive impairment (MCI) classification performance.

Method: Sixty study participants were evaluated with Miro Health version V.2. Healthy controls (HC), amnestic MCI (aMCI), and nonamnestic MCI (naMCI) ages 64-85 were evaluated with version V.3. Additional participants were recruited at Johns Hopkins Hospital to represent clinic patients, with wider ranges of age and diagnosis. In all, 90 HC, 21 aMCI, 17 naMCI, and 15 other cases were evaluated with V.3. Concurrent validity of the Miro Health variables and legacy neuropsychological test scores was assessed with Spearman correlations. Reliability was quantified with the scores' intraclass correlations. A machine-learning algorithm combined Miro Health variable scores into a Risk score to differentiate HC from MCI or MCI subtypes.

Results: In HC, correlations of Miro Health variables with legacy test scores ranged 0.27-0.68. Test-retest reliabilities ranged 0.25-0.79, with minimal learning effects. The Risk score differentiated individuals with aMCI from HC with an area under the receiver operator curve (AUROC) of 0.97; naMCI from HC with an AUROC of 0.80; combined MCI from HC with an AUROC of 0.89; and aMCI from naMCI with an AUROC of 0.83.

Conclusion: The Miro Health Mobile Assessment Platform provides valid and reliable assessment of neurobehavioral and cognitive status, effectively distinguishes between HC and MCI, and differentiates aMCI from naMCI.

背景:Miro Health移动评估平台由自我管理的神经行为和认知评估组成,这些评估通常由专业临床医生测量。目的:评估Miro Health移动评估平台的并发有效性、重测可靠性和轻度认知障碍(MCI)分类性能。方法:60名研究参与者使用Miro Health版本V.2进行评估。健康对照组(HC)、健忘症MCI(aMCI)和非健忘症MCAI(naMCI),年龄64-85岁,用V.3版进行评估。约翰斯·霍普金斯医院招募了更多的参与者来代表年龄和诊断范围更广的临床患者。总共有90例HC、21例aMCI、17例naMCI和15例其他病例用V.3进行了评估。Miro健康变量和遗留神经心理测试分数的同时有效性采用Spearman相关性进行评估。可靠性通过评分的组内相关性进行量化。一种机器学习算法将Miro Health变量得分合并为风险得分,以区分HC与MCI或MCI亚型。结果:在HC中,Miro Health变量与传统测试分数的相关性范围为0.27-0.68。测试-再测试的信度在0.25-0.79之间,学习效果最小。风险评分将aMCI患者与HC患者区分开来,受试者-操作者曲线下面积(AUROC)为0.97;来自AUROC为0.80的HC的naMCI;来自HC的组合MCI具有0.89的AUROC;和aMCI与naMCI的AUROC为0.83。结论:Miro Health移动评估平台提供了有效可靠的神经行为和认知状态评估,有效区分了HC和MCI,并区分了aMCI和naMCI。
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引用次数: 1
Graph Theory Analysis of Semantic Fluency in Russian-English Bilinguals. 俄英双语者语义流利度的图论分析。
IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2022-09-01 DOI: 10.1097/WNN.0000000000000312
Vidushi Sinha, Frances Lissemore, Alan J Lerner

Background: Semantic category fluency is a widely used task involving language, memory, and executive function. Previous studies of bilingual semantic fluency have shown only small differences between languages. Graph theory analyzes complex relationships in networks, including node and edge number, clustering coefficient, average path length, average number of direct neighbors, and scale-free and small-world properties.

Objective: To shed light on whether the underlying neural processes involved in semantic category fluency testing yield substantially different networks in different languages.

Method: We compared languages and methods using both network analysis and conventional analysis of word production. We administered the animal naming task to 51 Russian-English bilinguals in each language. We constructed network graphs using three methods: (a) simple association of unique co-occurring neighbors, (b) corrected associations between consecutive words occurring beyond chance, and (c) a network community approach using planar maximally filtered graphs. We compared the resultant network analytics as well as their scale-free and small-world properties.

Results: Participants produced more words in Russian than in English. Small-worldness metrics were variable between Russian and English but were consistent across the three graph theory analytical methods.

Conclusion: The networks had similar graph theory properties in both languages. The optimal methodology for creating networks from semantic category fluency remains to be determined.

背景:语义范畴流利性是一项广泛使用的任务,涉及语言、记忆和执行功能。先前对双语语义流利性的研究表明,语言之间的差异很小。图论分析网络中的复杂关系,包括节点数和边数、聚类系数、平均路径长度、平均直接邻居数以及无标度和小世界性质。目的:阐明语义类别流利性测试中涉及的潜在神经过程在不同语言中是否产生显著不同的网络。方法:我们使用网络分析和传统的造词分析来比较语言和方法。我们对每种语言的51名俄英双语者进行了动物命名任务。我们使用三种方法构建了网络图:(a)唯一共存邻居的简单关联,(b)偶然出现的连续单词之间的校正关联,以及(c)使用平面最大滤波图的网络社区方法。我们比较了由此产生的网络分析以及它们的无标度和小世界特性。结果:参与者产生的俄语单词比英语单词多。俄语和英语之间的小世界度指标是可变的,但在三种图论分析方法中是一致的。结论:网络在两种语言中具有相似的图论性质。根据语义类别流畅度创建网络的最佳方法仍有待确定。
{"title":"Graph Theory Analysis of Semantic Fluency in Russian-English Bilinguals.","authors":"Vidushi Sinha, Frances Lissemore, Alan J Lerner","doi":"10.1097/WNN.0000000000000312","DOIUrl":"10.1097/WNN.0000000000000312","url":null,"abstract":"<p><strong>Background: </strong>Semantic category fluency is a widely used task involving language, memory, and executive function. Previous studies of bilingual semantic fluency have shown only small differences between languages. Graph theory analyzes complex relationships in networks, including node and edge number, clustering coefficient, average path length, average number of direct neighbors, and scale-free and small-world properties.</p><p><strong>Objective: </strong>To shed light on whether the underlying neural processes involved in semantic category fluency testing yield substantially different networks in different languages.</p><p><strong>Method: </strong>We compared languages and methods using both network analysis and conventional analysis of word production. We administered the animal naming task to 51 Russian-English bilinguals in each language. We constructed network graphs using three methods: (a) simple association of unique co-occurring neighbors, (b) corrected associations between consecutive words occurring beyond chance, and (c) a network community approach using planar maximally filtered graphs. We compared the resultant network analytics as well as their scale-free and small-world properties.</p><p><strong>Results: </strong>Participants produced more words in Russian than in English. Small-worldness metrics were variable between Russian and English but were consistent across the three graph theory analytical methods.</p><p><strong>Conclusion: </strong>The networks had similar graph theory properties in both languages. The optimal methodology for creating networks from semantic category fluency remains to be determined.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154949/pdf/nihms-1814366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10130340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotypic and Brain Imaging Findings Associated With a 10p Proximal Deletion Including the WAC Gene: Case Report and Literature Review. 与包括WAC基因在内的10p近端缺失相关的表型和脑成像发现:病例报告和文献综述。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-09-01 DOI: 10.1097/WNN.0000000000000309
Hilmi Bolat, Hatice Derin, Gül Ünsel-Bolat

Microarray-based techniques are an important testing method in etiological studies of intellectual disability and autism spectrum disorder. Interstitial deletion in the p11-p12 region of chromosome 10 is rare, having been reported in just 12 cases to date. Intellectual disability associated with the WAC gene in this region is referred to as DeSanto-Shinawi syndrome . Although all individuals with p11-p12 region of chromosome 10 deletion share a common phenotype involving intellectual disability and dysmorphic features, individuals with DeSanto-Shinawi syndrome usually do not experience the cardiac and neurologic abnormalities or cryptorchidism associated with a 10p11-p12 deletion. With this case report, we aim to expand the phenotypic spectrum of 10p11-p12 deletion. Our patient was a 9-year-old boy with intellectual disability, autism symptoms, dysmorphic features, and behavioral abnormalities. He had no cardiac problems or neurologic symptoms such as hypotonia, feeding difficulties, or seizures. However, he presented cryptorchidism in addition to symptoms that are consistent with DeSanto-Shinawi syndrome. Array comparative genomic hybridization of genomic DNA isolated from a peripheral blood sample revealed a heterozygous deletion in 10p11.23-p12.1, which contains the WAC gene. We discuss our case in the context of a literature review of candidate genes. It is still difficult to establish genotype-phenotype correlations for neurologic, cardiac, and visual symptoms, and cryptorchidism, in individuals with a 10p11-p12 deletion. As more individuals are diagnosed with deletion in this chromosomal region, the associated phenotypes will become clearer.

基于微阵列技术是智力残疾和自闭症谱系障碍病因研究中的一种重要检测方法。10号染色体p11-p12区域的间质缺失是罕见的,迄今为止仅报道了12例。在该地区,与WAC基因相关的智力残疾被称为DeSanto-Shinawi综合征。尽管所有10号染色体p11-p12区域缺失的个体都有一个共同的表型,包括智力残疾和畸形特征,但患有DeSanto-Shinawi综合征的个体通常不会出现与10p11-p12缺失相关的心脏和神经异常或隐睾。本病例报告旨在扩大10p11-p12缺失的表型谱。我们的患者是一名9岁男孩,患有智力残疾、自闭症症状、畸形特征和行为异常。他没有心脏问题或神经系统症状,如张力减退、进食困难或癫痫发作。然而,除了与DeSanto-Shinawi综合征一致的症状外,他还表现出隐睾。从外周血样本中分离的基因组DNA的阵列比较基因组杂交显示10p111.23-p12.1中存在杂合缺失,该杂合缺失包含WAC基因。我们在候选基因的文献综述中讨论了我们的情况。在10p11-p12缺失的个体中,仍然很难建立神经、心脏和视觉症状以及隐睾的基因型-表型相关性。随着越来越多的个体被诊断为该染色体区域的缺失,相关表型将变得更加清晰。
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引用次数: 0
Distinguishing Between Genuine and Feigned Dementia Using Event-related Potentials. 利用事件相关电位区分真实痴呆和假装痴呆。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-09-01 DOI: 10.1097/WNN.0000000000000311
August M Price, Rocco Palumbo, Anna Marin, Prayerna Uppal, Cheongmin Suh, Andrew E Budson, Katherine W Turk

Background: Individuals with probable Alzheimer disease (AD) may perform below cutoffs on traditional, memory-based performance validity tests. Previous studies have found success using event-related potentials (ERPs) to detect feigned neurocognitive impairment in younger populations.

Objective: To evaluate the utility of an auditory oddball task in conjunction with the P3b peak amplitude to distinguish probable AD from simulated dementia.

Method: Twenty individuals with probable AD and 20 older healthy controls (HC) underwent an ERP auditory oddball protocol and the Test of Memory Malingering (TOMM). The HC were asked to perform honestly for one condition and to simulate dementia for the other. The individuals with probable AD were asked to perform honestly. The P3b peak amplitude and button press accuracy were collected from each participant and were analyzed to determine their effectiveness in detecting performance validity.

Results: The P3b peak amplitude remained stable regardless of behavioral condition in the HC group. When combined with the TOMM Trial 2 score, the P3b peak amplitude further improved the ability to correctly differentiate individuals with probable AD from HC simulating dementia with 100% sensitivity and 90% specificity.

Conclusion: The P3b peak amplitude was found to be an effective physiologic measure of cognitive impairment in individuals with probable AD compared with HC simulating dementia. When combined with the TOMM Trial 2 score, the P3b peak amplitude served as a promising performance validity measure for differentiating individuals with probable AD from HC simulating dementia.

背景:可能患有阿尔茨海默病(AD)的个体可能在传统的基于记忆的表现有效性测试中表现低于临界值。先前的研究已经发现,使用事件相关电位(ERPs)检测年轻人群中假装的神经认知障碍是成功的。目的:评估听觉古怪任务与P3b峰值振幅在区分可能的AD和模拟痴呆中的效用。方法:20名可能患有AD的患者和20名老年健康对照者(HC)接受了ERP听觉怪人方案和记忆损害测试(TOMM)。HC被要求对一种情况诚实地表现,对另一种情况模拟痴呆症。可能患有AD的患者被要求诚实行事。从每个参与者身上收集P3b峰值振幅和按钮按下准确度,并进行分析,以确定它们在检测绩效有效性方面的有效性。结果:无论HC组的行为状况如何,P3b峰值振幅都保持稳定。当与TOMM试验2评分相结合时,P3b峰值幅度进一步提高了正确区分可能患有AD的个体和HC模拟痴呆的能力,具有100%的敏感性和90%的特异性。结论:与HC模拟痴呆相比,P3b峰值振幅是衡量可能患有AD的个体认知障碍的有效生理指标。当与TOMM试验2评分相结合时,P3b峰值幅度是区分可能患有AD的个体和模拟HC的痴呆的个体的一个有希望的性能有效性指标。
{"title":"Distinguishing Between Genuine and Feigned Dementia Using Event-related Potentials.","authors":"August M Price,&nbsp;Rocco Palumbo,&nbsp;Anna Marin,&nbsp;Prayerna Uppal,&nbsp;Cheongmin Suh,&nbsp;Andrew E Budson,&nbsp;Katherine W Turk","doi":"10.1097/WNN.0000000000000311","DOIUrl":"10.1097/WNN.0000000000000311","url":null,"abstract":"<p><strong>Background: </strong>Individuals with probable Alzheimer disease (AD) may perform below cutoffs on traditional, memory-based performance validity tests. Previous studies have found success using event-related potentials (ERPs) to detect feigned neurocognitive impairment in younger populations.</p><p><strong>Objective: </strong>To evaluate the utility of an auditory oddball task in conjunction with the P3b peak amplitude to distinguish probable AD from simulated dementia.</p><p><strong>Method: </strong>Twenty individuals with probable AD and 20 older healthy controls (HC) underwent an ERP auditory oddball protocol and the Test of Memory Malingering (TOMM). The HC were asked to perform honestly for one condition and to simulate dementia for the other. The individuals with probable AD were asked to perform honestly. The P3b peak amplitude and button press accuracy were collected from each participant and were analyzed to determine their effectiveness in detecting performance validity.</p><p><strong>Results: </strong>The P3b peak amplitude remained stable regardless of behavioral condition in the HC group. When combined with the TOMM Trial 2 score, the P3b peak amplitude further improved the ability to correctly differentiate individuals with probable AD from HC simulating dementia with 100% sensitivity and 90% specificity.</p><p><strong>Conclusion: </strong>The P3b peak amplitude was found to be an effective physiologic measure of cognitive impairment in individuals with probable AD compared with HC simulating dementia. When combined with the TOMM Trial 2 score, the P3b peak amplitude served as a promising performance validity measure for differentiating individuals with probable AD from HC simulating dementia.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444996/pdf/nihms-1813003.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10505581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Executive Dysfunction, Social Cognition Impairment, and Gray Matter Pathology in Myotonic Dystrophy Type 2: A Pilot Study. 2型肌营养不良的执行功能障碍、社会认知障碍和灰质病理学:一项初步研究。
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2022-09-01 DOI: 10.1097/WNN.0000000000000314
Thomas Theodosiou, Foteini Christidi, Sofia Xirou, Efstratios Karavasilis, Peter Bede, Constantinos Papadopoulos, Georgios D Argyropoulos, Panagiotis Kourtesis, Varvara Pantolewn, Panagiotis Ferentinos, Evangelia Kararizou, Georgios Velonakis, Ioannis Zalonis, Georgios Papadimas

Background: In contrast to myotonic dystrophy type 1, the cognitive and radiologic profile of myotonic dystrophy type 2 (DM2) is relatively poorly characterized.

Objective: To conduct a pilot study to systematically evaluate cognitive and radiologic features in a cohort of Greek individuals with DM2.

Method: Eleven genetically confirmed individuals with DM2 and 26 age- and education-matched healthy controls were administered the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS) to screen for impairment in multiple cognitive domains. MRI data were evaluated by morphometric analyses to identify disease-specific gray and white matter alterations. The following statistical thresholds were used for cognitive comparisons: PFDR < 0.05 and Bayes factor (BF 10 ) >10.

Results: The DM2 group exhibited cognitive impairment (ECAS Total score; PFDR = 0.001; BF 10 = 108.887), which was dominated by executive impairment ( PFDR = 0.003; BF 10 = 25.330). A trend toward verbal fluency impairment was also identified. No significant impairments in memory, language, or visuospatial function were captured. The analysis of subscores revealed severe impairments in social cognition and alternation. Voxel-based morphometry identified widespread frontal, occipital, and subcortical gray matter atrophy, including the left superior medial frontal gyrus, right medial orbitofrontal gyrus, right operculum, right precuneus, bilateral fusiform gyri, and bilateral thalami.

Conclusion: DM2 may be associated with multifocal cortical and thalamic atrophy, which is likely to underpin the range of cognitive manifestations mostly characterized by executive impairment and specifically by impaired social cognition.

背景:与1型强直性营养不良相比,2型强直性肌营养不良(DM2)的认知和放射学特征相对较差。目的:进行一项初步研究,系统评估希腊DM2患者队列的认知和放射学特征。方法:对11名经基因证实的DM2患者和26名年龄和教育程度匹配的健康对照进行爱丁堡认知和行为肌萎缩侧索硬化症筛查(ECAS),以筛查多种认知障碍域。MRI数据通过形态计量学分析进行评估,以确定疾病特异性灰质和白质改变。以下统计阈值用于认知比较:PFDR<0.05和贝叶斯因子(BF 10)>10。结果:DM2组表现出认知障碍(ECAS总分;PFDR=0.001;BF 10=108.887),主要是执行障碍(PFDR=0.003;BF 10=25.330)。还发现了语言流利性障碍的趋势。没有发现记忆、语言或视觉空间功能的显著损伤。分量表分析显示,社会认知和交替方面存在严重障碍。基于体素的形态计量学确定了广泛的额、枕和皮质下灰质萎缩,包括左额上内侧回、右眶额内侧回、右侧盖、右侧楔前叶、双侧梭状回和双侧丘脑。结论:DM2可能与多灶性皮质和丘脑萎缩有关,这可能是一系列认知表现的基础,这些表现主要以执行障碍为特征,特别是以社会认知受损为特征。
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引用次数: 1
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Cognitive and Behavioral Neurology
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