首页 > 最新文献

Cognitive and Behavioral Neurology最新文献

英文 中文
The Attention Network Test in Parkinson and Lewy Body Disease: A Systematic Review 帕金森和路易体病的注意网络测试:系统回顾
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2022-03-01 DOI: 10.1097/WNN.0000000000000292
Jihyun Yang, Dana Pourzinal, T. Rheinberger, D. Copland, K. Mcmahon, G. Byrne, N. Dissanayaka
Background: The Attention Network Test (ANT) is a well-established measure of efficiency for the alerting, orienting, and executive attentional networks. However, its novel application in Parkinson disease (PD) and Lewy body dementia (LBD) research more broadly has yet to be evaluated systematically. Objective: To compare and consolidate the outcomes of studies reporting use of the ANT in PD and LBD groups and to identify the methodological considerations for the conduct of such studies. Method: We performed a systematic literature search for articles exploring attention in PD and LBD groups using the ANT. We excluded articles on the basis of irrelevant scope, non-English, and groups other than PD and LBD. Once the full text articles were identified, we extracted the data and assessed the studies’ quality. Results: The final sample included 16 articles ranging from low to moderate quality. Behavioral findings suggested a general slowing of responses yet preserved accuracy from the PD group compared with controls. Overall, the evidence was inconclusive regarding the state of the alerting network in the PD and LBD groups, mostly supportive of an intact orienting network, and strongly suggestive of an impaired executive network. Differences in sample stratification, patient symptomatology, and dopaminergic medication levels were identified as influential factors in the attentional results across studies. Conclusion: Although sparse, the existing evidence indicates that the ANT is a viable option for measuring attention in PD; it can also be harnessed to explore the impact of symptoms and medications on attentional networks in PD and LBD groups.
背景:注意力网络测试(ANT)是一种公认的衡量警报、定向和执行注意力网络效率的方法。然而,它在帕金森病(PD)和路易体痴呆(LBD)研究中的新应用尚待系统评估。目的:比较和巩固报告在帕金森病和LBD组中使用ANT的研究结果,并确定进行此类研究的方法考虑因素。方法:我们使用ANT对PD和LBD组的注意力进行了系统的文献检索。我们根据不相关的范围、非英语以及PD和LBD以外的群体排除了文章。一旦全文文章被确定,我们提取数据并评估研究的质量。结果:最终样本包括16篇质量从低到中等的文章。行为研究结果表明,与对照组相比,PD组的反应普遍放缓,但仍保持了准确性。总的来说,关于PD和LBD组的警报网络状态的证据是不确定的,主要支持完整的定向网络,并强烈暗示执行网络受损。样本分层、患者症状和多巴胺能药物水平的差异被确定为研究中注意力结果的影响因素。结论:虽然稀少,但现有证据表明,ANT是测量PD注意力的可行选择;它还可以用来探索症状和药物对PD和LBD组注意力网络的影响。
{"title":"The Attention Network Test in Parkinson and Lewy Body Disease: A Systematic Review","authors":"Jihyun Yang, Dana Pourzinal, T. Rheinberger, D. Copland, K. Mcmahon, G. Byrne, N. Dissanayaka","doi":"10.1097/WNN.0000000000000292","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000292","url":null,"abstract":"Background: The Attention Network Test (ANT) is a well-established measure of efficiency for the alerting, orienting, and executive attentional networks. However, its novel application in Parkinson disease (PD) and Lewy body dementia (LBD) research more broadly has yet to be evaluated systematically. Objective: To compare and consolidate the outcomes of studies reporting use of the ANT in PD and LBD groups and to identify the methodological considerations for the conduct of such studies. Method: We performed a systematic literature search for articles exploring attention in PD and LBD groups using the ANT. We excluded articles on the basis of irrelevant scope, non-English, and groups other than PD and LBD. Once the full text articles were identified, we extracted the data and assessed the studies’ quality. Results: The final sample included 16 articles ranging from low to moderate quality. Behavioral findings suggested a general slowing of responses yet preserved accuracy from the PD group compared with controls. Overall, the evidence was inconclusive regarding the state of the alerting network in the PD and LBD groups, mostly supportive of an intact orienting network, and strongly suggestive of an impaired executive network. Differences in sample stratification, patient symptomatology, and dopaminergic medication levels were identified as influential factors in the attentional results across studies. Conclusion: Although sparse, the existing evidence indicates that the ANT is a viable option for measuring attention in PD; it can also be harnessed to explore the impact of symptoms and medications on attentional networks in PD and LBD groups.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"35 1","pages":"1 - 13"},"PeriodicalIF":1.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43956332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anosognosia and Memory Encoding in Huntington Disease 亨廷顿病的病感失认和记忆编码
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2022-03-01 DOI: 10.1097/WNN.0000000000000293
Ciaran M. Considine, Shelby B. Hughes, Jessie Sellers Gibson, David Isaacs, Katherine E McDonell, R. Darby, D. Claassen
Background: Anosognosia can manifest as an unawareness of neurobehavioral symptoms in individuals with Huntington disease (HD). Measurement of anosognosia is challenging, but the Anosognosia Scale (AS) represents a brief option with promising findings in small samples. Objective: To replicate application of the AS in a larger HD sample than previous studies in order to assess psychometrics and demographic correlates and to investigate the genetic, motor, and neuropsychological correlates of the AS in individuals with HD. Method: We retrospectively reviewed the AS ratings of 74 genetically confirmed Huntington gene carriers, nearly all early motor manifest, who had been referred for clinical neuropsychological assessment. Concurrent clinical neurologic examination and neuropsychometric assessment data were compiled, where available (ns = 35–74). The severity of the anosognosia per AS ratings was characterized for the HD sample. Results: The AS ratings did not correlate with demographic variables, genetic markers, or motor dysfunction severity. Correlation analyses revealed that higher AS ratings correlated with worse recognition–discrimination memory performance (r = 0.38, P < 0.05) but not cognitive control on executive functioning performance or on collateral-reported frontal–behavioral symptoms. Higher AS ratings also correlated with fewer patient-reported depressive symptoms (r = –0.38, P < 0.01) and diurnal hypersomnia symptoms (r = –0.44, P < 0.01). Conclusion: Anosognosia (per AS) is associated with recognition–discrimination deficits and fewer self-reported neuropsychiatric symptoms in individuals with pre-to-early manifest HD, though not with HD severity per genetic or motor markers, nor to executive dysfunction or collateral-reported frontal–behavioral symptoms.
背景:在亨廷顿舞蹈症(HD)患者中,认知障碍可表现为对神经行为症状的不了解。嗅觉缺失的测量具有挑战性,但嗅觉缺失量表(AS)是一个简短的选择,在小样本中有很好的发现。目的:在比以往研究更大的HD样本中复制AS的应用,以评估心理测量学和人口学相关性,并研究HD患者AS的遗传、运动和神经心理学相关性。方法:我们回顾性地回顾了74名遗传确认的亨廷顿舞蹈症基因携带者的AS评分,这些携带者几乎都是早期运动表现,他们被转诊进行临床神经心理评估。在可用的情况下,同时汇编临床神经检查和神经计量评估数据(n=35-74)。根据AS评分对HD样本的嗅觉缺失严重程度进行了表征。结果:AS评分与人口统计学变量、遗传标志物或运动功能障碍严重程度无关。相关分析显示,较高的AS评分与较差的识别-辨别记忆表现相关(r=0.38,P<0.05),但与执行功能表现或附带报告的额叶行为症状的认知控制无关。较高的AS评分也与较少的患者报告的抑郁症状(r=-0.38,P<0.01)和昼夜嗜睡症状(r=0.44,P<0.01)相关,尽管没有遗传或运动标志物的HD严重程度,也没有执行功能障碍或附带报告的额叶行为症状。
{"title":"Anosognosia and Memory Encoding in Huntington Disease","authors":"Ciaran M. Considine, Shelby B. Hughes, Jessie Sellers Gibson, David Isaacs, Katherine E McDonell, R. Darby, D. Claassen","doi":"10.1097/WNN.0000000000000293","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000293","url":null,"abstract":"Background: Anosognosia can manifest as an unawareness of neurobehavioral symptoms in individuals with Huntington disease (HD). Measurement of anosognosia is challenging, but the Anosognosia Scale (AS) represents a brief option with promising findings in small samples. Objective: To replicate application of the AS in a larger HD sample than previous studies in order to assess psychometrics and demographic correlates and to investigate the genetic, motor, and neuropsychological correlates of the AS in individuals with HD. Method: We retrospectively reviewed the AS ratings of 74 genetically confirmed Huntington gene carriers, nearly all early motor manifest, who had been referred for clinical neuropsychological assessment. Concurrent clinical neurologic examination and neuropsychometric assessment data were compiled, where available (ns = 35–74). The severity of the anosognosia per AS ratings was characterized for the HD sample. Results: The AS ratings did not correlate with demographic variables, genetic markers, or motor dysfunction severity. Correlation analyses revealed that higher AS ratings correlated with worse recognition–discrimination memory performance (r = 0.38, P < 0.05) but not cognitive control on executive functioning performance or on collateral-reported frontal–behavioral symptoms. Higher AS ratings also correlated with fewer patient-reported depressive symptoms (r = –0.38, P < 0.01) and diurnal hypersomnia symptoms (r = –0.44, P < 0.01). Conclusion: Anosognosia (per AS) is associated with recognition–discrimination deficits and fewer self-reported neuropsychiatric symptoms in individuals with pre-to-early manifest HD, though not with HD severity per genetic or motor markers, nor to executive dysfunction or collateral-reported frontal–behavioral symptoms.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"35 1","pages":"40 - 48"},"PeriodicalIF":1.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48408372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diffusion Tensor Imaging Correlates of Resilience Following Adolescent Traumatic Brain Injury. 青少年颅脑损伤后弥散张量成像与恢复力的相关性。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000283
Adam T Schmidt, Hannah M Lindsey, Emily Dennis, Elisabeth A Wilde, Brian D Biekman, Zili D Chu, Gerri R Hanten, Dana L Formon, Matthew S Spruiell, Jill V Hunter, Harvey S Levin

Background: Traumatic brain injury (TBI) is associated with considerable mortality and morbidity in adolescents, but positive outcomes are possible. Resilience is the concept that some individuals flourish despite significant adversity.

Objective: To determine if there is a relationship between resilience-promoting factors that are known to promote resilience and white matter (WM) microstructure 1 year after complicated mild TBI or moderate or severe TBI that is sustained by adolescents.

Method: We examined the relationship between performance on a self-report measure of resilience-promoting factors and WM integrity assessed by diffusion tensor imaging in a group of adolescents who had sustained either a TBI (n = 38) or an orthopedic injury (OI) (n = 23).

Results: Immediately following injury, the individuals with TBI and the OI controls had comparable levels of resilience-promoting factors; however, at 1 year post injury, the TBI group endorsed fewer resilience-promoting factors and exhibited WM disruption compared with the OI controls. The individuals with TBI who had more resilience-promoting factors at 1 year post injury exhibited increased WM integrity, but the OI controls did not. Findings were particularly strong for the following structures: anterior corona radiata, anterior limb of the internal capsule, and genu of the corpus callosum-structures that are implicated in social cognition and are frequently disrupted after TBI. Relationships were notable for caregiver and community-level resilience-promoting factors.

Conclusion: The current findings are some of the first to indicate neurobiological evidence of previously noted buffering effects of resilience-promoting factors in individuals with TBI.

背景:创伤性脑损伤(TBI)与青少年的相当大的死亡率和发病率有关,但积极的结果是可能的。韧性是指一些人在重大逆境中仍能茁壮成长的概念。目的:确定已知促进恢复力的恢复力促进因素与青少年并发轻度或中度或重度TBI后1年的白质(WM)微观结构之间是否存在关系。方法:我们研究了一组青少年的自我报告恢复力促进因素的表现与通过扩散张量成像评估的WM完整性之间的关系 = 38)或矫形损伤(OI)(n = 23).结果:受伤后,TBI患者和OI对照组的恢复力促进因子水平相当;然而,在损伤后1年,与OI对照组相比,TBI组支持较少的恢复力促进因素,并表现出WM中断。在损伤后1年具有更多恢复力促进因素的TBI患者表现出WM完整性增加,但OI对照组没有。以下结构的研究结果尤其强烈:前放射冠、内囊前肢和胼胝体膝部结构,这些结构与社会认知有关,在TBI后经常被破坏。人际关系在照顾者和社区层面的恢复力促进因素方面显著。结论:目前的研究结果首次表明了先前注意到的恢复力促进因子对TBI患者的缓冲作用的神经生物学证据。
{"title":"Diffusion Tensor Imaging Correlates of Resilience Following Adolescent Traumatic Brain Injury.","authors":"Adam T Schmidt,&nbsp;Hannah M Lindsey,&nbsp;Emily Dennis,&nbsp;Elisabeth A Wilde,&nbsp;Brian D Biekman,&nbsp;Zili D Chu,&nbsp;Gerri R Hanten,&nbsp;Dana L Formon,&nbsp;Matthew S Spruiell,&nbsp;Jill V Hunter,&nbsp;Harvey S Levin","doi":"10.1097/WNN.0000000000000283","DOIUrl":"10.1097/WNN.0000000000000283","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is associated with considerable mortality and morbidity in adolescents, but positive outcomes are possible. Resilience is the concept that some individuals flourish despite significant adversity.</p><p><strong>Objective: </strong>To determine if there is a relationship between resilience-promoting factors that are known to promote resilience and white matter (WM) microstructure 1 year after complicated mild TBI or moderate or severe TBI that is sustained by adolescents.</p><p><strong>Method: </strong>We examined the relationship between performance on a self-report measure of resilience-promoting factors and WM integrity assessed by diffusion tensor imaging in a group of adolescents who had sustained either a TBI (n = 38) or an orthopedic injury (OI) (n = 23).</p><p><strong>Results: </strong>Immediately following injury, the individuals with TBI and the OI controls had comparable levels of resilience-promoting factors; however, at 1 year post injury, the TBI group endorsed fewer resilience-promoting factors and exhibited WM disruption compared with the OI controls. The individuals with TBI who had more resilience-promoting factors at 1 year post injury exhibited increased WM integrity, but the OI controls did not. Findings were particularly strong for the following structures: anterior corona radiata, anterior limb of the internal capsule, and genu of the corpus callosum-structures that are implicated in social cognition and are frequently disrupted after TBI. Relationships were notable for caregiver and community-level resilience-promoting factors.</p><p><strong>Conclusion: </strong>The current findings are some of the first to indicate neurobiological evidence of previously noted buffering effects of resilience-promoting factors in individuals with TBI.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"259-274"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647770/pdf/nihms-1743087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39681868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Body: A Guide for Occupants. 身体:居住者指南。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000272
Howard S Kirshner
{"title":"The Body: A Guide for Occupants.","authors":"Howard S Kirshner","doi":"10.1097/WNN.0000000000000272","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000272","url":null,"abstract":"","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"323-324"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of Cognitive Reserve on Cognition in Individuals With Central Nervous System Disease. 认知储备对中枢神经系统疾病患者认知的影响。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000282
Varna R Jammula, Heather Leeper, Mark R Gilbert, Diane Cooper, Terri S Armstrong

Cognitive reserve (CR) has been proposed to account for functional outcome differences in brain pathology and its clinical manifestations. The purpose of our paper is to systematically review the effects of CR on cognitive outcomes in individuals with neurodegenerative and structural CNS diseases. We performed a systematic search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsychInfo using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Seventeen studies met the predetermined inclusion criteria and were selected for review. Education level was the most commonly used measure for CR, and various neuropsychological tests were used to measure cognitive outcomes. Regardless of the CNS disease of the individuals, almost all of the studies reported a positive association between CR and cognitive outcomes when they were evaluated cross-sectionally. However, when evaluated longitudinally, CR had either no effect on, or a negative association with, cognitive outcomes. Based on studies across a broad spectrum of CNS diseases, our findings suggest that CR may serve as a predictor of cognitive outcomes in individuals with CNS diseases. However, studies to date are limited by a lack of imaging analyses and standardized assessment strategies. The ability to use a standardized measure to assess the longitudinal effects of CR may allow for the development of more targeted treatment methods, resulting in improved disease outcomes for individuals.

认知储备(CR)已被提出用于解释大脑病理学及其临床表现中的功能结果差异。我们论文的目的是系统地回顾CR对神经退行性和结构性中枢神经系统疾病患者认知结果的影响。我们使用PRISMA(系统评价和荟萃分析的首选报告项目)指南对PubMed、CINAHL(护理和相关健康文献的累积指数)和PsychInfo进行了系统搜索。17项研究符合预定的纳入标准,并被选中进行审查。教育水平是CR最常用的衡量标准,各种神经心理学测试用于衡量认知结果。无论个体的中枢神经系统疾病如何,当对其进行横断面评估时,几乎所有的研究都报告了CR与认知结果之间的正相关。然而,当纵向评估时,CR对认知结果没有影响,或者与认知结果呈负相关。基于对广泛中枢神经系统疾病的研究,我们的研究结果表明,CR可能是中枢神经系统患者认知结果的预测指标。然而,迄今为止的研究受到缺乏成像分析和标准化评估策略的限制。使用标准化测量来评估CR的纵向影响的能力可能允许开发更有针对性的治疗方法,从而改善个体的疾病结果。
{"title":"Effects of Cognitive Reserve on Cognition in Individuals With Central Nervous System Disease.","authors":"Varna R Jammula,&nbsp;Heather Leeper,&nbsp;Mark R Gilbert,&nbsp;Diane Cooper,&nbsp;Terri S Armstrong","doi":"10.1097/WNN.0000000000000282","DOIUrl":"10.1097/WNN.0000000000000282","url":null,"abstract":"<p><p>Cognitive reserve (CR) has been proposed to account for functional outcome differences in brain pathology and its clinical manifestations. The purpose of our paper is to systematically review the effects of CR on cognitive outcomes in individuals with neurodegenerative and structural CNS diseases. We performed a systematic search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsychInfo using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Seventeen studies met the predetermined inclusion criteria and were selected for review. Education level was the most commonly used measure for CR, and various neuropsychological tests were used to measure cognitive outcomes. Regardless of the CNS disease of the individuals, almost all of the studies reported a positive association between CR and cognitive outcomes when they were evaluated cross-sectionally. However, when evaluated longitudinally, CR had either no effect on, or a negative association with, cognitive outcomes. Based on studies across a broad spectrum of CNS diseases, our findings suggest that CR may serve as a predictor of cognitive outcomes in individuals with CNS diseases. However, studies to date are limited by a lack of imaging analyses and standardized assessment strategies. The ability to use a standardized measure to assess the longitudinal effects of CR may allow for the development of more targeted treatment methods, resulting in improved disease outcomes for individuals.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"245-258"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39405585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Cerebellar Ischemia Presenting as Transient Global Amnesia. 小脑缺血表现为短暂性全局性遗忘。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000287
Jonathan Morena, Hera A Kamdar, Amir Adeli

Transient global amnesia (TGA) consists of acute-onset anterograde amnesia and typically resolves within 24 hours. Reported etiologies of TGA include transient ischemia to the hippocampus or thalamus, migraine, venous flow abnormalities, and epilepsy. There are no reports of cerebellar ischemia as an etiology of TGA. A 78-year-old woman with a medical history of diabetes presented to the Ohio State University ER after a period of anterograde amnesia lasting 3 hours. She was alert during the event, but asked the same questions repeatedly. Upon arrival to the ER, she was hypertensive but clinically back to baseline, with no recall of the 3-hour time period. An MRI of her brain revealed an isolated hyperintense signal on diffusion-weighted imaging (DWI) at the junction of the superior cerebellum and vermis, with apparent diffusion coefficient correlation. Vascular imaging of the brain and neck and a routine EEG were unremarkable. We diagnosed her with cerebellar ischemia presenting as TGA. She had no head injury, migraine, or history of epilepsy to suggest alternative etiologies of TGA. An increasing amount of literature has reported that the cerebellum is linked to the limbic system. A case series of SPECT imaging on individuals with TGA revealed transient cerebellar vermis hypoperfusion in addition to hippocampal DWI changes. We present what may be a novel report of isolated cerebellar ischemia presenting as TGA, and we add to the literature for clinicians to consider the possibility that damage to the cerebellum or its circuit to the cerebrum or thalamus can present as TGA.

短暂性全全性遗忘症(TGA)由急性发作的顺行性遗忘症组成,通常在24小时内消退。据报道,TGA的病因包括海马或丘脑短暂性缺血、偏头痛、静脉流动异常和癫痫。没有关于小脑缺血作为TGA病因的报道。一位有糖尿病病史的78岁女性在持续3小时的顺行性失忆后被送到俄亥俄州立大学急诊室。她在活动期间很警觉,但总是问同样的问题。到达急诊室时,她是高血压,但临床恢复到基线,没有回忆起3小时的时间。脑部MRI示上小脑与蚓部交界处有孤立的高信号,弥散系数明显相关。脑和颈部血管成像及常规脑电图无显著差异。我们诊断她为小脑缺血表现为TGA。她没有头部损伤、偏头痛或癫痫史,提示TGA的其他病因。越来越多的文献报道,小脑与大脑边缘系统有关。TGA患者的一系列病例SPECT成像显示,除了海马DWI改变外,还有短暂的小脑蚓部灌注不足。我们提出了一份可能是孤立性小脑缺血表现为TGA的新报告,我们为临床医生增加了文献,以考虑小脑或其通往大脑或丘脑的回路的损伤可能表现为TGA。
{"title":"Cerebellar Ischemia Presenting as Transient Global Amnesia.","authors":"Jonathan Morena,&nbsp;Hera A Kamdar,&nbsp;Amir Adeli","doi":"10.1097/WNN.0000000000000287","DOIUrl":"https://doi.org/10.1097/WNN.0000000000000287","url":null,"abstract":"<p><p>Transient global amnesia (TGA) consists of acute-onset anterograde amnesia and typically resolves within 24 hours. Reported etiologies of TGA include transient ischemia to the hippocampus or thalamus, migraine, venous flow abnormalities, and epilepsy. There are no reports of cerebellar ischemia as an etiology of TGA. A 78-year-old woman with a medical history of diabetes presented to the Ohio State University ER after a period of anterograde amnesia lasting 3 hours. She was alert during the event, but asked the same questions repeatedly. Upon arrival to the ER, she was hypertensive but clinically back to baseline, with no recall of the 3-hour time period. An MRI of her brain revealed an isolated hyperintense signal on diffusion-weighted imaging (DWI) at the junction of the superior cerebellum and vermis, with apparent diffusion coefficient correlation. Vascular imaging of the brain and neck and a routine EEG were unremarkable. We diagnosed her with cerebellar ischemia presenting as TGA. She had no head injury, migraine, or history of epilepsy to suggest alternative etiologies of TGA. An increasing amount of literature has reported that the cerebellum is linked to the limbic system. A case series of SPECT imaging on individuals with TGA revealed transient cerebellar vermis hypoperfusion in addition to hippocampal DWI changes. We present what may be a novel report of isolated cerebellar ischemia presenting as TGA, and we add to the literature for clinicians to consider the possibility that damage to the cerebellum or its circuit to the cerebrum or thalamus can present as TGA.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"319-322"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dynamic Aphasia as a Variant of Frontotemporal Dementia. 动态失语症是额颞叶痴呆的一种变体。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000289
Adithya Chandregowda, Heather M Clark, Joseph R Duffy, Mary M Machulda, Val J Lowe, Jennifer L Whitwell, Keith A Josephs

We describe two individuals with progressive verbal difficulty who exhibited impairment of propositional language, with relatively well-preserved auditory comprehension, naming, and repetition-a profile that is consistent with dynamic aphasia. By providing a brief review of pertinent literature and the results from our neurologic, speech and language, neuropsychological, and neuroimaging testing, this report sheds light on the infrequently reported dynamic aphasia in the context of frontotemporal dementia. Our patients' insights into their verbal difficulty tend to support the notion that dynamic aphasia results from interference at the stage where thoughts are converted into verbal messages-that is, the thought-verbal interface.

我们描述了两名具有进行性言语困难的个体,他们表现出命题语言的障碍,具有相对完好的听觉理解、命名和重复——这一特征与动态失语症一致。通过对相关文献和我们的神经、言语和语言、神经心理学和神经影像学测试结果进行简要回顾,本报告揭示了额颞叶痴呆中很少报道的动态失语症。我们的患者对其言语困难的见解倾向于支持这样一种观点,即动态失语症是由思想转化为言语信息阶段的干扰引起的,即思想-言语界面。
{"title":"Dynamic Aphasia as a Variant of Frontotemporal Dementia.","authors":"Adithya Chandregowda,&nbsp;Heather M Clark,&nbsp;Joseph R Duffy,&nbsp;Mary M Machulda,&nbsp;Val J Lowe,&nbsp;Jennifer L Whitwell,&nbsp;Keith A Josephs","doi":"10.1097/WNN.0000000000000289","DOIUrl":"10.1097/WNN.0000000000000289","url":null,"abstract":"<p><p>We describe two individuals with progressive verbal difficulty who exhibited impairment of propositional language, with relatively well-preserved auditory comprehension, naming, and repetition-a profile that is consistent with dynamic aphasia. By providing a brief review of pertinent literature and the results from our neurologic, speech and language, neuropsychological, and neuroimaging testing, this report sheds light on the infrequently reported dynamic aphasia in the context of frontotemporal dementia. Our patients' insights into their verbal difficulty tend to support the notion that dynamic aphasia results from interference at the stage where thoughts are converted into verbal messages-that is, the thought-verbal interface.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"303-318"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647805/pdf/nihms-1742999.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Intellectual Curiosity and Action Initiation are Subtypes of Apathy Affected in Huntington Disease Gene Expansion Carriers. 智力好奇心和行动启动是亨廷顿舞蹈症基因扩增携带者中受影响的Apathy的亚型。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000286
Rebecca K Hendel, Marie N N Hellem, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel

Background: Apathy is a prevalent behavioral syndrome of Huntington disease (HD) that can result in severe loss of function for the individual with HD and substantial caregiver distress. Research-based evidence of apathy is characterized by methodological differences, and there is a deficiency in the evidence concerning the subtypes of apathy.

Objective: To characterize apathy in premanifest and motor-manifest HD gene expansion carriers and controls using the Short Problem Behaviors Assessment for Huntington's Disease (PBA-s) and the Lille Apathy Rating Scale (LARS).

Method: We included 82 HD gene expansion carriers (premanifest and motor manifest) and 32 controls (Mini-Mental State Examination score ≥24 and Montreal Cognitive Assessment score ≥19) in the study. We quantified apathy using the PBA-s and the LARS and performed correlation analyses between the global LARS score and motor function, cytosine-adenine-guanine repeat length, cytosine-adenine-guanine Age Product score, and neuropsychiatric and cognitive symptoms.

Results: The motor-manifest HD gene expansion carriers scored significantly higher than the controls on the global score and the Intellectual Curiosity and Action Initiation subscales of the LARS. Apathy was present in 28% of the HD gene expansion carriers (including 7 premanifest). The apathetic participants had a significantly higher motor score, significantly higher scores on the neuropsychiatric instruments, and significantly lower cognitive scores compared with the controls.

Conclusion: Apathy is a frequent syndrome that is found in individuals with HD. Apathy has a specific expression, with symptoms such as reduced initiation, voluntary actions, and interests, that might be related to the underlying neuropathology. Apathy is related to disease progression, neuropsychiatric symptoms, and cognitive impairments.

背景:冷漠是亨廷顿舞蹈症(HD)的一种常见行为综合征,可导致HD患者严重丧失功能,并造成严重的照顾者痛苦。基于研究的冷漠证据的特点是方法上的差异,并且缺乏关于冷漠亚型的证据。目的:使用亨廷顿舞蹈症短期问题行为评估(PBA-s)和里尔冷漠评定量表(LARS)来表征产前和运动表现型HD基因扩增携带者和对照组的冷漠(迷你精神状态检查得分≥24,蒙特利尔认知评估得分≥19)。我们使用PBA-s和LARS对冷漠进行了量化,并对整体LARS评分与运动功能、胞嘧啶腺嘌呤-鸟嘌呤重复长度、胞嘧啶-腺嘌呤鸟嘌呤年龄乘积评分以及神经精神和认知症状之间进行了相关性分析。结果:运动显性HD基因扩增携带者在LARS的整体得分和智力好奇心和行动启动分量表上的得分显著高于对照组。28%的HD基因扩增携带者存在Apathy(包括7例早产者)。与对照组相比,冷漠的参与者的运动得分显著更高,在神经精神仪器上的得分显著更大,认知得分显著更低。结论:冷漠是HD患者常见的综合征。冷漠有一种特定的表现,其症状包括主动性降低、自愿行为和兴趣,这可能与潜在的神经病理学有关。冷漠与疾病进展、神经精神症状和认知障碍有关。
{"title":"Intellectual Curiosity and Action Initiation are Subtypes of Apathy Affected in Huntington Disease Gene Expansion Carriers.","authors":"Rebecca K Hendel,&nbsp;Marie N N Hellem,&nbsp;Lena E Hjermind,&nbsp;Jørgen E Nielsen,&nbsp;Asmus Vogel","doi":"10.1097/WNN.0000000000000286","DOIUrl":"10.1097/WNN.0000000000000286","url":null,"abstract":"<p><strong>Background: </strong>Apathy is a prevalent behavioral syndrome of Huntington disease (HD) that can result in severe loss of function for the individual with HD and substantial caregiver distress. Research-based evidence of apathy is characterized by methodological differences, and there is a deficiency in the evidence concerning the subtypes of apathy.</p><p><strong>Objective: </strong>To characterize apathy in premanifest and motor-manifest HD gene expansion carriers and controls using the Short Problem Behaviors Assessment for Huntington's Disease (PBA-s) and the Lille Apathy Rating Scale (LARS).</p><p><strong>Method: </strong>We included 82 HD gene expansion carriers (premanifest and motor manifest) and 32 controls (Mini-Mental State Examination score ≥24 and Montreal Cognitive Assessment score ≥19) in the study. We quantified apathy using the PBA-s and the LARS and performed correlation analyses between the global LARS score and motor function, cytosine-adenine-guanine repeat length, cytosine-adenine-guanine Age Product score, and neuropsychiatric and cognitive symptoms.</p><p><strong>Results: </strong>The motor-manifest HD gene expansion carriers scored significantly higher than the controls on the global score and the Intellectual Curiosity and Action Initiation subscales of the LARS. Apathy was present in 28% of the HD gene expansion carriers (including 7 premanifest). The apathetic participants had a significantly higher motor score, significantly higher scores on the neuropsychiatric instruments, and significantly lower cognitive scores compared with the controls.</p><p><strong>Conclusion: </strong>Apathy is a frequent syndrome that is found in individuals with HD. Apathy has a specific expression, with symptoms such as reduced initiation, voluntary actions, and interests, that might be related to the underlying neuropathology. Apathy is related to disease progression, neuropsychiatric symptoms, and cognitive impairments.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"295-302"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study. 多奈哌齐和美金刚对阿尔茨海默病行为和心理症状的影响:为期六个月的开放标签研究。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000285
Petra Bago Rožanković, Marjan Rožanković, Jasna Badžak, Maristela Stojić, Ivana Šušak Sporiš
Background: Behavioral and psychological symptoms of dementia (BPSD) are common in individuals with Alzheimer disease (AD). Donepezil and memantine are both widely used for the treatment of moderate AD. Objective: To evaluate the effects of donepezil and memantine in relieving BPSD in individuals with moderate AD. Method: We conducted a prospective, randomized, 6-month clinical trial involving 85 individuals with moderate AD divided into two groups: group 1 (n = 42) was treated with donepezil; group 2 (n = 43) was treated with memantine. We used the Neuropsychiatric Inventory (NPI) to assess the prevalence and severity of BPSD at baseline and after 6 months of treatment with donepezil or memantine. Results: The two groups’ baseline characteristics, including age, sex, mean length of education, and disease duration, were comparable, as were their baseline Mini-Mental State Examination scores. The NPI Total score improved from baseline to month 6 in both groups (P < 0.0001). Analyses of the NPI subdomains revealed that both donepezil treatment and memantine treatment produced statistically significant improvement in all of the NPI domains except euphoria and apathy, for which no improvement was observed after memantine treatment. Both treatments were well tolerated, with mostly mild and transient adverse effects. Conclusion: Specific drugs for AD, including donepezil and memantine, may be effective in treating BPSD in individuals with moderate AD, with a favorable safety profile.
背景:痴呆症(BPSD)的行为和心理症状在阿尔茨海默病(AD)患者中很常见。多奈哌齐和美金刚都被广泛用于治疗中度AD。目的:评估多奈哌齐和美金刚在缓解中度AD患者BPSD方面的效果。方法:我们进行了一项为期6个月的前瞻性随机临床试验,85名中度AD患者分为两组:第1组(n=42)接受多奈哌嗪治疗;第2组(n=43)用美金刚治疗。我们使用神经精神量表(NPI)来评估基线和多奈哌齐或美金刚治疗6个月后BPSD的患病率和严重程度。结果:两组的基线特征,包括年龄、性别、平均受教育年限和疾病持续时间,以及他们的基线迷你精神状态检查分数具有可比性。从基线到第6个月,两组的NPI总分均有所改善(P<0.0001)。对NPI亚结构域的分析显示,多奈哌齐治疗和美金刚治疗在除欣快感和冷漠外的所有NPI领域都产生了统计学上显著的改善,美金刚治疗后未观察到任何改善。这两种治疗都具有良好的耐受性,大多有轻微和短暂的不良反应。结论:治疗AD的特效药,包括多奈哌齐和美金刚,可能对中度AD患者的BPSD有效,具有良好的安全性。
{"title":"Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study.","authors":"Petra Bago Rožanković,&nbsp;Marjan Rožanković,&nbsp;Jasna Badžak,&nbsp;Maristela Stojić,&nbsp;Ivana Šušak Sporiš","doi":"10.1097/WNN.0000000000000285","DOIUrl":"10.1097/WNN.0000000000000285","url":null,"abstract":"Background: Behavioral and psychological symptoms of dementia (BPSD) are common in individuals with Alzheimer disease (AD). Donepezil and memantine are both widely used for the treatment of moderate AD. Objective: To evaluate the effects of donepezil and memantine in relieving BPSD in individuals with moderate AD. Method: We conducted a prospective, randomized, 6-month clinical trial involving 85 individuals with moderate AD divided into two groups: group 1 (n = 42) was treated with donepezil; group 2 (n = 43) was treated with memantine. We used the Neuropsychiatric Inventory (NPI) to assess the prevalence and severity of BPSD at baseline and after 6 months of treatment with donepezil or memantine. Results: The two groups’ baseline characteristics, including age, sex, mean length of education, and disease duration, were comparable, as were their baseline Mini-Mental State Examination scores. The NPI Total score improved from baseline to month 6 in both groups (P < 0.0001). Analyses of the NPI subdomains revealed that both donepezil treatment and memantine treatment produced statistically significant improvement in all of the NPI domains except euphoria and apathy, for which no improvement was observed after memantine treatment. Both treatments were well tolerated, with mostly mild and transient adverse effects. Conclusion: Specific drugs for AD, including donepezil and memantine, may be effective in treating BPSD in individuals with moderate AD, with a favorable safety profile.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"288-294"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Honorific Speech Impairment: A Characteristic Sign of Frontotemporal Dementia. 敬语障碍:额颞叶痴呆的一个特征性体征。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2021-12-02 DOI: 10.1097/WNN.0000000000000284
Weon Kyeong Hong, Ji Hye Yoon, Hyemin Jang, Soo Jin Yoon, So Young Moon, Hee Jin Kim, Duk L Na

Background: Individuals with the behavioral variant of frontotemporal dementia (bvFTD) exhibit various levels of abulia, disinhibition, impaired judgment, and decline in executive function. Empirical evidence has shown that individuals with bvFTD also often exhibit difficulty using honorific speech, which expresses respect to another party or addressee.

Objective: To analyze differences in the ability to use honorific speech among individuals with bvFTD, individuals with dementia of the Alzheimer type (AD dementia), and individuals with normal cognition (NC).

Method: A total of 53 native Korean speakers (13 bvFTD, 20 AD dementia, and 20 NC) completed an experimental honorific speech task (HST) that involved both expressive and receptive tasks. We analyzed the number of correct responses and error patterns separately for an expressive task and for a receptive task.

Results: The bvFTD group had significantly fewer correct responses on the HST compared with the AD dementia and NC groups. The bvFTD group exhibited more misjudgment errors in identifying nonhonorific speech as honorific speech in the expressive task, and significantly longer response times in the receptive task, than the AD dementia and NC groups. Significant associations were identified between HST scores and cortical atrophy in the temporal and frontotemporal lobes.

Conclusion: A decline in the ability to use honorific speech may be a diagnosable behavioral and psychiatric symptom for bvFTD in Korean-speaking individuals. This decline in individuals with bvFTD could be attributed to multiple factors, including social manners (politeness) and impaired social language use ability (pragmatics).

背景:患有额颞叶痴呆(bvFTD)行为变体的个体表现出不同程度的滥用、去抑制、判断受损和执行功能下降。经验证据表明,bvFTD患者在使用敬语时也经常表现出困难,敬语表达了对另一方或收件人的尊重。目的:分析bvFTD患者、阿尔茨海默型痴呆(AD痴呆)患者和认知正常(NC)患者敬语使用能力的差异。我们分别分析了表达任务和接受任务的正确回答和错误模式的数量。结果:与AD痴呆组和NC组相比,bvFTD组对HST的正确反应明显较少。与AD痴呆组和NC组相比,bvFTD组在表达任务中将非规范语识别为敬语时表现出更多的误判错误,在接受任务中表现出更长的反应时间。HST评分与颞叶和额颞叶皮质萎缩之间存在显著相关性。结论:韩语使用者敬语使用能力下降可能是bvFTD的一种可诊断的行为和精神症状。bvFTD患者的这种下降可能归因于多种因素,包括社交礼仪(礼貌)和社交语言使用能力受损(语用学)。
{"title":"Honorific Speech Impairment: A Characteristic Sign of Frontotemporal Dementia.","authors":"Weon Kyeong Hong,&nbsp;Ji Hye Yoon,&nbsp;Hyemin Jang,&nbsp;Soo Jin Yoon,&nbsp;So Young Moon,&nbsp;Hee Jin Kim,&nbsp;Duk L Na","doi":"10.1097/WNN.0000000000000284","DOIUrl":"10.1097/WNN.0000000000000284","url":null,"abstract":"<p><strong>Background: </strong>Individuals with the behavioral variant of frontotemporal dementia (bvFTD) exhibit various levels of abulia, disinhibition, impaired judgment, and decline in executive function. Empirical evidence has shown that individuals with bvFTD also often exhibit difficulty using honorific speech, which expresses respect to another party or addressee.</p><p><strong>Objective: </strong>To analyze differences in the ability to use honorific speech among individuals with bvFTD, individuals with dementia of the Alzheimer type (AD dementia), and individuals with normal cognition (NC).</p><p><strong>Method: </strong>A total of 53 native Korean speakers (13 bvFTD, 20 AD dementia, and 20 NC) completed an experimental honorific speech task (HST) that involved both expressive and receptive tasks. We analyzed the number of correct responses and error patterns separately for an expressive task and for a receptive task.</p><p><strong>Results: </strong>The bvFTD group had significantly fewer correct responses on the HST compared with the AD dementia and NC groups. The bvFTD group exhibited more misjudgment errors in identifying nonhonorific speech as honorific speech in the expressive task, and significantly longer response times in the receptive task, than the AD dementia and NC groups. Significant associations were identified between HST scores and cortical atrophy in the temporal and frontotemporal lobes.</p><p><strong>Conclusion: </strong>A decline in the ability to use honorific speech may be a diagnosable behavioral and psychiatric symptom for bvFTD in Korean-speaking individuals. This decline in individuals with bvFTD could be attributed to multiple factors, including social manners (politeness) and impaired social language use ability (pragmatics).</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"34 4","pages":"275-287"},"PeriodicalIF":1.4,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Cognitive and Behavioral Neurology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1