Pub Date : 2026-01-19DOI: 10.1016/j.burns.2026.107872
Jialong Yang , An Wang , Zhengyang Qi , Panshen Xu , Hebin Pan , Weilong Song , Kaitao Wang , Dingsheng Lin
Background
Skin flap necrosis due to ischemia-reperfusion (I/R) injury remains a major obstacle in plastic and reconstructive surgery. Galangin (Gal) is a natural flavonoid with potent antioxidant and anti-inflammatory properties; its effect on ischemic flap necrosis remains unclear.
Methods
Network pharmacology and molecular docking were used to predict the interaction between Gal and SIRT1. In vitro, human umbilical vein endothelial cells were subjected to oxygen-glucose deprivation/reperfusion to simulate I/R injury, and subsequent assessments of cell viability and ferroptosis were performed. The SIRT1 inhibitor EX527 and the ferroptosis inhibitor Ferrostatin-1 were used to verify the ferroptosis-related mechanisms. In vivo, a modified McFarlane skin flap model was created in rats. Gal-treated groups were compared to a control group to evaluate flap survival, blood perfusion, histological changes, and the expression of key proteins in the SIRT1/FOXO1 pathway.
Results
In vitro, Gal protected HUVECs by suppressing ferroptosis. Mechanistically, Gal upregulated SIRT1, promoted FOXO1 deacetylation, increased expression of downstream proteins and inhibited lipid peroxidation. These protective effects were diminished by SIRT1 inhibition. In vivo, Gal treatment significantly increased flap survival area and blood perfusion in a dose-dependent manner. It also suppressed neutrophil infiltration, reduced MDA levels, increased SOD activity, and inhibited pro-inflammatory cytokines and activate anti-ferroptosis proteins.
Conclusions
Gal enhances skin flap survival by suppressing ferroptosis, oxidative stress, and inflammation via activation of the SIRT1/FOXO1 pathway.
{"title":"Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation","authors":"Jialong Yang , An Wang , Zhengyang Qi , Panshen Xu , Hebin Pan , Weilong Song , Kaitao Wang , Dingsheng Lin","doi":"10.1016/j.burns.2026.107872","DOIUrl":"10.1016/j.burns.2026.107872","url":null,"abstract":"<div><h3>Background</h3><div>Skin flap necrosis due to ischemia-reperfusion (I/R) injury remains a major obstacle in plastic and reconstructive surgery. Galangin (Gal) is a natural flavonoid with potent antioxidant and anti-inflammatory properties; its effect on ischemic flap necrosis remains unclear.</div></div><div><h3>Methods</h3><div>Network pharmacology and molecular docking were used to predict the interaction between Gal and SIRT1. In vitro, human umbilical vein endothelial cells were subjected to oxygen-glucose deprivation/reperfusion to simulate I/R injury, and subsequent assessments of cell viability and ferroptosis were performed. The SIRT1 inhibitor EX527 and the ferroptosis inhibitor Ferrostatin-1 were used to verify the ferroptosis-related mechanisms. In vivo, a modified McFarlane skin flap model was created in rats. Gal-treated groups were compared to a control group to evaluate flap survival, blood perfusion, histological changes, and the expression of key proteins in the SIRT1/FOXO1 pathway.</div></div><div><h3>Results</h3><div>In vitro, Gal protected HUVECs by suppressing ferroptosis. Mechanistically, Gal upregulated SIRT1, promoted FOXO1 deacetylation, increased expression of downstream proteins and inhibited lipid peroxidation. These protective effects were diminished by SIRT1 inhibition. In vivo, Gal treatment significantly increased flap survival area and blood perfusion in a dose-dependent manner. It also suppressed neutrophil infiltration, reduced MDA levels, increased SOD activity, and inhibited pro-inflammatory cytokines and activate anti-ferroptosis proteins.</div></div><div><h3>Conclusions</h3><div>Gal enhances skin flap survival by suppressing ferroptosis, oxidative stress, and inflammation via activation of the SIRT1/FOXO1 pathway.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107872"},"PeriodicalIF":2.9,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.burns.2026.107871
Like Zhang, Lijing Zhu, Haiyu Fan, Wei Yi, Ning Sun, Mingzhu Zhuang, Ping Feng, Guosheng Wu, Zhaofan Xia
The blood urea nitrogen-to-albumin ratio (BAR) has been proposed as a prognostic marker in various clinical settings, yet its predictive value in patients with extensive burns remains unclear. This study aimed to explore the potential association between the BAR and the prognosis of patients with extensive burns. We conducted a retrospective, single-center cohort study at the Burn Center of Changhai Hospital, including patients admitted between May 1, 2005, and December 31, 2022. Eligible patients were randomly assigned to a training set and a validation set in a 7:3 ratio. Univariate and multivariate Cox regression analyses were performed to identify mortality-associated factors, including age, sex, burn etiology, total body surface area burned (TBSA), full-thickness burn area (FTBA), blood urea nitrogen, serum creatinine, serum albumin, and BAR. The predictive value of BAR was assessed using receiver operating characteristic (ROC) curves and Kaplan-Meier survival analysis. The model was validated using the internal validation set. A total of 372 patients with extensive burns were included (73.92 % male; 81.99 % flame burns). Age, TBSA, FTBA, inhalation injury, tracheostomy, and BAR were identified as independent predictors of 30-day mortality. The same variables, excluding age, also predicted 60-day mortality. BAR outperformed serum albumin in prognostic accuracy. The area under the receiver operating characteristic curve for 30-day mortality was 0.801 (95 % confidence interval [95 % CI]: 0.729-0.872; sensitivity: 0.750; specificity: 0.728) and for 60-day mortality was 0.801 (95 % CI: 0.734-0.867; sensitivity: 0.714; specificity: 0.731). BAR is an accessible, cost-effective prognostic marker with high predictive accuracy for 30-day and 60-day mortality in patients with extensive burns. It demonstrates superior prognostic utility compared to individual markers and may support risk stratification in burn care.
{"title":"Early blood urea nitrogen-albumin ratio as a prognostic marker in severe burn patients: A retrospective clinical study.","authors":"Like Zhang, Lijing Zhu, Haiyu Fan, Wei Yi, Ning Sun, Mingzhu Zhuang, Ping Feng, Guosheng Wu, Zhaofan Xia","doi":"10.1016/j.burns.2026.107871","DOIUrl":"https://doi.org/10.1016/j.burns.2026.107871","url":null,"abstract":"<p><p>The blood urea nitrogen-to-albumin ratio (BAR) has been proposed as a prognostic marker in various clinical settings, yet its predictive value in patients with extensive burns remains unclear. This study aimed to explore the potential association between the BAR and the prognosis of patients with extensive burns. We conducted a retrospective, single-center cohort study at the Burn Center of Changhai Hospital, including patients admitted between May 1, 2005, and December 31, 2022. Eligible patients were randomly assigned to a training set and a validation set in a 7:3 ratio. Univariate and multivariate Cox regression analyses were performed to identify mortality-associated factors, including age, sex, burn etiology, total body surface area burned (TBSA), full-thickness burn area (FTBA), blood urea nitrogen, serum creatinine, serum albumin, and BAR. The predictive value of BAR was assessed using receiver operating characteristic (ROC) curves and Kaplan-Meier survival analysis. The model was validated using the internal validation set. A total of 372 patients with extensive burns were included (73.92 % male; 81.99 % flame burns). Age, TBSA, FTBA, inhalation injury, tracheostomy, and BAR were identified as independent predictors of 30-day mortality. The same variables, excluding age, also predicted 60-day mortality. BAR outperformed serum albumin in prognostic accuracy. The area under the receiver operating characteristic curve for 30-day mortality was 0.801 (95 % confidence interval [95 % CI]: 0.729-0.872; sensitivity: 0.750; specificity: 0.728) and for 60-day mortality was 0.801 (95 % CI: 0.734-0.867; sensitivity: 0.714; specificity: 0.731). BAR is an accessible, cost-effective prognostic marker with high predictive accuracy for 30-day and 60-day mortality in patients with extensive burns. It demonstrates superior prognostic utility compared to individual markers and may support risk stratification in burn care.</p>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 3","pages":"107871"},"PeriodicalIF":2.9,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-18DOI: 10.1016/j.burns.2026.107869
Jiuyuan Qin , Jie Deng , Yulin Zou
{"title":"Comment on: \"Characterization and analysis of the skin mycobiome in keloid: A case-control study\"","authors":"Jiuyuan Qin , Jie Deng , Yulin Zou","doi":"10.1016/j.burns.2026.107869","DOIUrl":"10.1016/j.burns.2026.107869","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 3","pages":"Article 107869"},"PeriodicalIF":2.9,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-18DOI: 10.1016/j.burns.2026.107862
Leopoldo C. Cancio
{"title":"Editorial: The rise of the robot authors","authors":"Leopoldo C. Cancio","doi":"10.1016/j.burns.2026.107862","DOIUrl":"10.1016/j.burns.2026.107862","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107862"},"PeriodicalIF":2.9,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.burns.2026.107867
Mehdi Ayaz
{"title":"The diagnostic pitfall of Marjolin's ulcer in old burn scars: When negative biopsy is misleading - A cautionary report.","authors":"Mehdi Ayaz","doi":"10.1016/j.burns.2026.107867","DOIUrl":"https://doi.org/10.1016/j.burns.2026.107867","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 3","pages":"107867"},"PeriodicalIF":2.9,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.burns.2026.107865
François Thuau, Théodore Lahmar, Ugo Lancien, Pierre Perrot
{"title":"Comment on: “Correlation of hemoglobin levels and mortality in burn patients”","authors":"François Thuau, Théodore Lahmar, Ugo Lancien, Pierre Perrot","doi":"10.1016/j.burns.2026.107865","DOIUrl":"10.1016/j.burns.2026.107865","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107865"},"PeriodicalIF":2.9,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.burns.2026.107864
Man Hin Kong , Alexander J. Baldwin , Ryan Kerstein
Aim
This study aimed to examine the relationship between socioeconomic status, measured by the Index of Multiple Deprivation (IMD), and the adequacy of first aid provided for burn injuries.
Methods
A retrospective cohort study was conducted including all patients (paediatric and adult) treated for thermal burns at a regional burn unit between 1 May and 31 July 2024. Socioeconomic status was assessed using IMD deciles. First aid was categorised as “adequate” (cooling with water for ≥20 min) or “inadequate,” with inadequate first aid further classified as “damaging” (e.g., ice, toothpaste, raw egg) or “not damaging.” Logistic regression analyses adjusted for age, sex, burn aetiology and size of burn.
Results
269 patients were included (median age 28.3 years; 66.9 % adults; 50.9 % male). Scalds were the most common aetiology (59.5 %), and most burns were superficial partial thickness (82.5 %). The median IMD decile was 7 (IQR 5–9). Increasing socioeconomic deprivation (lower IMD decile) was significantly associated with inadequate first aid (OR 0.898 [per unit decrease in IMD decile] 95 % CI 0.807–0.998, p = 0.046). Greater deprivation was also associated with increased odds of harmful first aid practices, compared with adequate first aid (RRR 0.836, 95 % CI 0.737–0.948, p = 0.005).
Conclusion
Socioeconomic deprivation is inversely associated with adequate burn first aid and positively associated with harmful practices. Targeted public health interventions are needed to address this disparity.
目的本研究旨在探讨以多重剥夺指数（Index of Multiple Deprivation， IMD）衡量的社会经济地位与烧伤急救是否充足之间的关系。方法回顾性队列研究，纳入2024年5月1日至7月31日在某地区烧伤科接受热烧伤治疗的所有患者（儿童和成人）。使用IMD十分位数评估社会经济地位。急救被分类为“充分”（用水冷却≥20 min）或“不充分”，不充分的急救进一步被分类为“破坏性”（如冰、牙膏、生鸡蛋）或“无破坏性”。Logistic回归分析调整了年龄、性别、烧伤病因和烧伤大小。结果纳入269例患者，中位年龄28.3岁，成人66.9% ，男性50.9% 。烫伤是最常见的病因（59.5% %），大多数烧伤是浅表部分厚度（82.5% %）。IMD十分位数中位数为7 （IQR 5-9）。社会经济剥夺增加（IMD十分位数较低）与急救不足显著相关（OR 0.898[每单位IMD十分位数下降]95 % CI 0.807-0.998, p = 0.046）。与充分的急救相比，更严重的剥夺也与有害急救做法的几率增加有关（RRR 0.836, 95 % CI 0.737-0.948, p = 0.005）。结论社会经济剥夺与充分的烧伤急救负相关，与有害做法正相关。需要有针对性的公共卫生干预措施来解决这一差距。
{"title":"The impact of socioeconomic deprivation on the adequacy of burn first aid: a retrospective cohort study","authors":"Man Hin Kong , Alexander J. Baldwin , Ryan Kerstein","doi":"10.1016/j.burns.2026.107864","DOIUrl":"10.1016/j.burns.2026.107864","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to examine the relationship between socioeconomic status, measured by the Index of Multiple Deprivation (IMD), and the adequacy of first aid provided for burn injuries.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted including all patients (paediatric and adult) treated for thermal burns at a regional burn unit between 1 May and 31 July 2024. Socioeconomic status was assessed using IMD deciles. First aid was categorised as “adequate” (cooling with water for ≥20 min) or “inadequate,” with inadequate first aid further classified as “damaging” (e.g., ice, toothpaste, raw egg) or “not damaging.” Logistic regression analyses adjusted for age, sex, burn aetiology and size of burn.</div></div><div><h3>Results</h3><div>269 patients were included (median age 28.3 years; 66.9 % adults; 50.9 % male). Scalds were the most common aetiology (59.5 %), and most burns were superficial partial thickness (82.5 %). The median IMD decile was 7 (IQR 5–9). Increasing socioeconomic deprivation (lower IMD decile) was significantly associated with inadequate first aid (OR 0.898 [per unit decrease in IMD decile] 95 % CI 0.807–0.998, p = 0.046). Greater deprivation was also associated with increased odds of harmful first aid practices, compared with adequate first aid (RRR 0.836, 95 % CI 0.737–0.948, p = 0.005).</div></div><div><h3>Conclusion</h3><div>Socioeconomic deprivation is inversely associated with adequate burn first aid and positively associated with harmful practices. Targeted public health interventions are needed to address this disparity.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107864"},"PeriodicalIF":2.9,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.burns.2026.107866
Yan-Yan Chen , Yi-Fei Yang , Yu-Yun Xiong, Hui Sun , Yu-Mei Li
{"title":"Comment on: Characterization and analysis of the skin mycobiome in keloid: A case-control study","authors":"Yan-Yan Chen , Yi-Fei Yang , Yu-Yun Xiong, Hui Sun , Yu-Mei Li","doi":"10.1016/j.burns.2026.107866","DOIUrl":"10.1016/j.burns.2026.107866","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107866"},"PeriodicalIF":2.9,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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