IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-11-04 DOI: 10.1016/j.burns.2025.107767

Noor Obaidi , Kristo Nuutila , Jamie Neelon , Victoria Diaz , Kristin Anselmo , Rodney K. Chan

Background

Split-thickness skin grafting (STSG) is the standard of care for treating major skin loss but is associated with significant donor site morbidity, including pain, prolonged healing, hypertrophic scarring, and pigmentation changes. Full-thickness skin column (FTSC) grafting has emerged as an alternative approach to transplant autologous skin in the management of full-thickness wounds. This clinical study evaluated an electronic FTSC harvesting and application device called the Autologous Regeneration of Tissue (ART). The ART device is designed to harvest 316 FTSCs from a small donor area and transplant them onto the recipient site in just a few minutes.

Methods

A clinical study was conducted comparing donor site wounds created with the ART device to those created with a conventional dermatome to harvest STSGs. Patients with full-thickness wounds that required skin grafting were enrolled in the study. Donor sites using the ART device and a dermatome were created on each participant. The donor sites were followed for up to 60 days after harvesting and were assessed for inflammation, pain, healing, and scarring on days 3, 7, 14, 30, and 60.

Results

In total, the study included five patients, and five ART donor sites were compared with five STSG donor sites. The results showed that by day 7, all the ART donor sites were fully healed, while the STSG donor sites were near full closure (97 %) by day 14. Pain measured using the 0–10 visual analog scale (VAS) indicated significantly less pain in the ART donor sites on day 7. Quality of healing measures using both the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS) showed significantly less scarring in the ART donor sites on postoperative day and 60.

Conclusions

It was shown that the ART device was easy to use and enabled the harvesting of hundreds of FTSCs from a small donor area and their application onto the recipient site in just a couple of minutes. The ART donor site exhibited faster healing, reduced pain, and less inflammation and scarring. However, due to the small sample size, these results should be considered preliminary.

背景：裂厚皮肤移植（STSG）是治疗严重皮肤缺损的标准护理方法，但与严重的供区发病率相关，包括疼痛、愈合时间延长、肥厚性疤痕和色素沉着改变。全层皮柱（FTSC）移植已成为全层创面移植的一种替代方法。本临床研究评估了一种称为组织自体再生（ART）的电子FTSC采集和应用装置。ART设备的设计目的是从一个小的供体区域收集316个FTSCs，并在几分钟内将它们移植到受体部位。方法对ART创面与传统皮组创面进行临床比较。需要植皮的全层伤口患者被纳入研究。在每个参与者身上创建使用ART设备的供体部位和皮肤组。采集后对供体部位进行长达60天的随访，并在第3、7、14、30和60天评估炎症、疼痛、愈合和疤痕。结果共纳入5例患者，5个ART供体与5个STSG供体进行比较。结果显示，到第7天，所有ART供区完全愈合，而到第14天，STSG供区接近完全闭合（97% %）。使用0-10视觉模拟评分（VAS）测量疼痛显示，第7天ART供体部位疼痛明显减轻。使用温哥华疤痕量表（VSS）和患者和观察者疤痕评估量表（POSAS）进行的愈合质量测量显示，ART供体部位在术后1天和60天的疤痕明显减少。结论该装置易于使用，可在几分钟内从一小块供体区域采集数百个FTSCs并将其应用于受体部位。ART供体部位愈合更快，疼痛减轻，炎症和疤痕减少。然而，由于样本量小，这些结果应该被认为是初步的。

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引用次数: 0

Insights from comparing blood perfusion metrics and Vancouver Scar Scale in keloid assessment 比较血液灌注指标和温哥华疤痕量表在瘢痕疙瘩评估中的意义

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-11-04 DOI: 10.1016/j.burns.2025.107766

Junxian Wen , Zhijin Li , Shuo Li , Lin Jin , Huiying Gao , Nanze Yu , Xiaojun Wang

Keloids are pathological scars characterized by excessive fibroproliferation that extend beyond the boundaries of the original wound. Their assessment and treatment remain challenging due to variability in severity and response to interventions. Current evaluation methods, such as the Vancouver Scar Scale (VSS), rely heavily on subjective observation, which can limit consistency and accuracy. Laser Speckle Contrast Imaging (LSCI) has emerged as an objective tool capable of evaluating keloid vascularity by assessing blood perfusion. This retrospective study analyzed 176 keloid lesions from 99 patients to explore the utility of LSCI in assessing keloid severity and monitoring treatment outcomes. Changes in blood perfusion (PU) ratios derived from LSCI (PU_{keloid/control}) before and after treatment were compared the corresponding pre- and post-treatment VSS scores. The results demonstrated a significant correlation between PU_{keloid/control} and VSS (ρ = 0.308, p < 0.001), with linear regression showing an association between decreases in perfusion ratio and reductions in VSS (R² = 0.539, p < 0.01). Clinical cases demonstrated that PU_{keloid/control} effectively identifies high-perfusion areas, guiding targeted interventions and improving treatment precision. The results suggest LSCI provides an objective, non-invasive method to assess keloid vascularity, complementing traditional tools to enhance scar evaluation and treatment planning.

瘢痕疙瘩是一种病理性疤痕，其特征是纤维增生过度，超出了原始伤口的边界。由于其严重程度和对干预措施的反应不同，对其的评估和治疗仍然具有挑战性。目前的评估方法，如温哥华疤痕量表（VSS），严重依赖于主观观察，这可能会限制一致性和准确性。激光散斑对比成像（LSCI）已经成为一种客观的工具，能够通过评估血液灌注来评估瘢痕疙瘩的血管状况。本回顾性研究分析了来自99例患者的176个瘢痕疙瘩病变，以探讨LSCI在评估瘢痕疙瘩严重程度和监测治疗结果中的应用。比较治疗前后LSCI （PUkeloid/control）的血流灌注（PU）比率的变化。结果显示PUkeloid/control与VSS之间存在显著相关性（ρ = 0.308, p <； 0.001），线性回归显示灌注比降低与VSS降低之间存在相关性（R²= 0.539,p <； 0.01）。临床病例表明，PUkeloid/control能有效识别高灌注区，指导有针对性的干预，提高治疗精度。结果表明，LSCI提供了一种客观、无创的方法来评估瘢痕疙瘩的血管状况，补充了传统的工具来加强疤痕评估和治疗计划。

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引用次数: 0

Skeletal muscle dysfunction in severe burns: identification of essential genes and drug discovery 严重烧伤的骨骼肌功能障碍：必要基因的鉴定和药物的发现。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-11-01 DOI: 10.1016/j.burns.2025.107762

Bai Hailiang , Bai Xiafen , Duan Hongjie , Lv Dawei , Zheng Jinguang , Wei Bin , Zhang Xulong , Liu Hongqi , Jiang Haiyue

Skeletal muscle dysfunction (SMD) is a common clinical feature among patients with severe burns and plays a crucial role in the recovery and prognosis of burn patients. However, the molecular targets and signal pathways of SMD after burns have not been fully understood, and there is an even greater lack of effective treatment measures. In this study, firstly, genes commonly related to SMD and functional recovery were obtained from the literature. Techniques included constructing protein-protein networks via the MCODE and cytoHubba plugins of Cytoscape, conducting GO analysis and KEGG analysis, and verifying the findings in animal models of severe burn-induced SMD by qRT-PCR. Subsequently, the key genes and signal pathways were determined by using GeneMANIA analysis. The transcription factors and ceRNA networks of the hub genes were identified, and the drug molecules that control the hub genes were obtained. Finally, molecular docking between gene targets and drug molecules was carried out, and the ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties of the drug molecules were verified. We identified 15 hub genes, and qRT-PCR results showed that 14 genes had significant differences, including IL6, TNF, IGF1, STAT3, IL10, AGT, LEP, CCL2, SIRT1, CASP3, MAPK3, PPARG, ALB, and IRS1. By analyzing the internal relationships, it was found that the gene STAT3 and the JAK/STAT3 pathway are the molecular targets and signal pathways of SMD. The transcription factors, ceRNA networks, and drug molecules were also determined. In addition, after molecular docking and ADMET analysis, it was found that the drug fluticasone performed excellently in all aspects. In conclusion, STAT3 was identified as the key target and signal pathway for functional recovery after SMD in burn patients.

骨骼肌功能障碍（SMD）是严重烧伤患者常见的临床特征，对烧伤患者的恢复和预后起着至关重要的作用。然而，烧伤后SMD的分子靶点和信号通路尚未完全了解，更缺乏有效的治疗措施。本研究首先从文献中获得与SMD和功能恢复相关的基因。技术包括通过Cytoscape的MCODE和cytoHubba插件构建蛋白-蛋白网络，进行GO分析和KEGG分析，并通过qRT-PCR在严重烧伤致SMD动物模型中验证研究结果。随后，通过GeneMANIA分析确定关键基因和信号通路。鉴定了枢纽基因的转录因子和ceRNA网络，获得了控制枢纽基因的药物分子。最后进行基因靶点与药物分子的分子对接，验证药物分子的ADMET（吸收、分布、代谢、排泄和毒性）特性。我们鉴定出15个枢纽基因，qRT-PCR结果显示有14个基因存在显著差异，包括IL6、TNF、IGF1、STAT3、IL10、AGT、LEP、CCL2、SIRT1、CASP3、MAPK3、PPARG、ALB和IRS1。通过内部关系分析，发现STAT3基因和JAK/STAT3通路是SMD的分子靶点和信号通路。转录因子、ceRNA网络和药物分子也被确定。此外，经过分子对接和ADMET分析，发现氟替卡松在各方面表现优异。综上所述，STAT3是烧伤患者SMD后功能恢复的关键靶点和信号通路。

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引用次数: 0

Comments on "The impact of negative pressure wound therapy on epidermal stem cells and keratinocyte growth factor in deep dermal burn injury: An experimental study" 《负压创面治疗对深皮烧伤患者表皮干细胞及角化细胞生长因子影响的实验研究》

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-11-01 DOI: 10.1016/j.burns.2025.107757

Nanru Peng, Xinzhi Peng

引用次数: 0

Comments on: "Persistent inflammation, immunosuppression, and catabolism syndrome and sepsis in pediatric burns" 评论：“儿童烧伤的持续炎症、免疫抑制、分解代谢综合征和败血症”

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-10-31 DOI: 10.1016/j.burns.2025.107764

Mehran Hesaraki

引用次数: 0

Healthcare workers' perceptions of burn care in New South Wales (NSW): guiding a burn model of care 在新南威尔士州（NSW）医护人员烧伤护理的看法：指导烧伤护理模式。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-10-30 DOI: 10.1016/j.burns.2025.107760

Siobhan M. Connolly , Andrew JA Holland , Louise Higgins , Husna Razee , Natalie Taylor , Rebecca Q. Ivers

Introduction

Burn-injured patients are managed by staff with differing levels of experience. Although considerable evidence is available regarding the assessment and treatment of burn injuries, there remains a lack of research on burn care systems. This study aimed to gather insights and recommendations from healthcare workers involved in caring for burn-injured patients, to inform the development of a burn model of care.

Methods

Twenty-two healthcare workers involved in burn care in New South Wales were interviewed in this qualitative study between January and June 2023. Semi-structured interviews were conducted via videoconferencing, focusing on perceptions of burn care and recommendations for improvement.

Results

Data were analysed thematically, categorised into main themes and sub-themes. Main themes included: caring for burn patients: challenges across the continuum; improving access to quality, comprehensive and culturally appropriate care; and strengthening consumer engagement in care, prevention and education. Sub-themes included: providing coordinated, multidisciplinary and holistic care throughout the journey; improving the post-discharge experience, process, rehabilitation, and transition; keeping patients closer to home; and enhancing staff skills through education.

Discussion

Healthcare workers recognise the challenges of equitable access for diverse, rural, and remote populations. Furthermore, the significance of effective education, communication, collaboration and consumer engagement in care, prevention, and education was emphasised. Issues such as the accessibility of education and virtual care resources were also discussed. Gaining insights from healthcare workers can enhance understanding of where gaps exist in the burn care system, enabling their resolution through the implementation of well-designed models of care.

简介：烧伤患者由不同经验水平的工作人员管理。虽然有相当多的证据可以获得关于烧伤的评估和治疗，但仍然缺乏对烧伤护理系统的研究。本研究旨在收集参与烧伤患者护理的医护人员的见解和建议，为烧伤护理模式的发展提供信息。方法：于2023年1月至6月对新南威尔士州22名从事烧伤护理的医护人员进行了定性研究。通过视频会议进行半结构化访谈，重点关注烧伤护理的看法和改进建议。结果：数据按主题进行分析，分为主要主题和次要主题。主题包括：烧伤患者的护理：整个连续体的挑战；改善获得高质量、全面和文化上适当的护理的机会；加强消费者在护理、预防和教育方面的参与。分主题包括：在整个旅程中提供协调、多学科和全面的护理；改善出院后的经历、过程、康复和过渡；让病人离家更近；通过教育提高员工技能。讨论：卫生保健工作者认识到多样化、农村和偏远人口公平获得服务的挑战。此外，还强调了有效教育、沟通、协作和消费者参与护理、预防和教育的重要性。还讨论了教育和虚拟护理资源的可及性等问题。从卫生保健工作者那里获得见解可以加强对烧伤护理系统中存在差距的理解，从而通过实施精心设计的护理模式来解决这些差距。

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引用次数: 0

Socioeconomic determinants of acid attacks against women in Bangladesh 孟加拉国妇女遭受硫酸袭击的社会经济决定因素

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-10-30 DOI: 10.1016/j.burns.2025.107763

Md. Sanaul Haque Mondal , Masahiro Shoji

Introduction

Acid attacks, a form of violence that involves throwing acid at human bodies, are a serious violation of fundamental human rights. Although acid violence is observed worldwide, quantitative evidence on the socioeconomic determinants of its prevalence is scarce. This study aimed to quantitatively examine the relationships between the prevalence of acid attacks against women and traditional gender norms and acid availability at the district level in Bangladesh, a developing country with high prevalence of such attacks.

Methods

Data on acid attacks were collected from media reports between 2005 and 2023, confirming 836 victims from 625 attacks. Traditional gender norms were approximated by child marriage, female labor force participation, women’s participation in intra-household decision-making, and the presence of garment factories in the district, while the number of textile factories approximated acid availability. Descriptive statistics on the media reports’ data were discussed. Ordinary least squares regression analysis using district-level aggregated data was performed to identify the determinants of acid attacks.

Results

The results demonstrated that women accounted for 77 % of victims, while primary perpetrators were men. Over a quarter of attacks against women were perpetrated by their husbands or ex-husbands. The attacks against women were more prevalent in the districts with stronger traditional gender norms and higher acid availability.

Conclusion

To the best of our knowledge, this is the first study to quantitatively uncover the socioeconomic determinants of acid attacks using representative data. The findings of this study will assist policymakers and relevant stakeholders in their plans to eliminate acid violence.

泼酸攻击是一种向人体泼酸的暴力行为，是对基本人权的严重侵犯。尽管泼酸暴力在世界各地都有发生，但关于其流行的社会经济决定因素的定量证据却很少。这项研究的目的是定量地研究孟加拉国对妇女的泼酸袭击的发生率与地区一级传统性别规范和泼酸供应之间的关系，孟加拉国是一个这种袭击发生率很高的发展中国家。方法从2005年至2023年的媒体报道中收集硫酸袭击的数据，确认625起袭击中有836名受害者。传统的性别规范近似于童婚、女性劳动力参与、妇女参与家庭内部决策以及该地区制衣厂的存在，而纺织厂的数量近似于酸的可用性。讨论了媒体报道数据的描述性统计。使用地区级汇总数据进行普通最小二乘回归分析，以确定酸攻击的决定因素。结果结果表明，女性占受害者的77% %，而主要肇事者是男性。对妇女的攻击有四分之一以上是由她们的丈夫或前夫实施的。针对妇女的袭击在传统性别规范较强、硫酸供应较高的地区更为普遍。据我们所知，这是第一个使用代表性数据定量揭示酸攻击的社会经济决定因素的研究。这项研究的结果将有助于决策者和相关利益攸关方制定消除硫酸暴力的计划。

{"title":"Socioeconomic determinants of acid attacks against women in Bangladesh","authors":"Md. Sanaul Haque Mondal , Masahiro Shoji","doi":"10.1016/j.burns.2025.107763","DOIUrl":"10.1016/j.burns.2025.107763","url":null,"abstract":"<div><h3>Introduction</h3><div>Acid attacks, a form of violence that involves throwing acid at human bodies, are a serious violation of fundamental human rights. Although acid violence is observed worldwide, quantitative evidence on the socioeconomic determinants of its prevalence is scarce. This study aimed to quantitatively examine the relationships between the prevalence of acid attacks against women and traditional gender norms and acid availability at the district level in Bangladesh, a developing country with high prevalence of such attacks.</div></div><div><h3>Methods</h3><div>Data on acid attacks were collected from media reports between 2005 and 2023, confirming 836 victims from 625 attacks. Traditional gender norms were approximated by child marriage, female labor force participation, women’s participation in intra-household decision-making, and the presence of garment factories in the district, while the number of textile factories approximated acid availability. Descriptive statistics on the media reports’ data were discussed. Ordinary least squares regression analysis using district-level aggregated data was performed to identify the determinants of acid attacks.</div></div><div><h3>Results</h3><div>The results demonstrated that women accounted for 77 % of victims, while primary perpetrators were men. Over a quarter of attacks against women were perpetrated by their husbands or ex-husbands. The attacks against women were more prevalent in the districts with stronger traditional gender norms and higher acid availability.</div></div><div><h3>Conclusion</h3><div>To the best of our knowledge, this is the first study to quantitatively uncover the socioeconomic determinants of acid attacks using representative data. The findings of this study will assist policymakers and relevant stakeholders in their plans to eliminate acid violence.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107763"},"PeriodicalIF":2.9,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjunctive curcumin nano-micelles reduce overall pruritus intensity in refractory post-burn pruritus: A randomized controlled trial 辅助姜黄素纳米胶束减少难治性烧伤后瘙痒的总体瘙痒强度：一项随机对照试验。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-10-28 DOI: 10.1016/j.burns.2025.107761

Laya Alirezaei , Hassan Golmohammadi , Mohammad Hassan Pourrashid , Ali Asghar Kheiri , Parvin Sarbakhsh , Sama Samankan , Afshin Gharekhani

Post-burn pruritus (PBP) is a common and refractory condition that can significantly impair quality of life (QoL). Curcumin, a bioactive compound with anti-inflammatory and neuroprotective properties, has been proposed as a therapeutic option for chronic pruritus. This study evaluated the efficacy of a nano-micelle formulation of curcumin in patients with refractory PBP.

In this randomized controlled trial, 100 adults with PBP were assigned to receive standard treatment alone or with curcumin nano-micelle capsules (40 mg, twice daily) for 12 weeks. Outcomes included pruritus severity, frequency, distribution, sleep condition, sleep disturbance, total pruritus intensity, and QoL (ItchyQoL), assessed at baseline, week 6, and week 12. Analyses were performed using mixed-effects models with group, time, and group×time as factors.

Both groups demonstrated significant within-group improvements in some pruritus domains. However, in the mixed-effects model, curcumin produced a significant between-group reduction in total pruritus intensity (adjusted mean difference −2.83; 95 % CI −5.54 to −0.11; p = 0.041). No significant between-group effects were observed for individual domains. Sleep condition improved with curcumin (adjusted mean difference −0.50; 95 % CI −1.04–0.03) but did not reach statistical significance. QoL improved significantly over time (time effect p = 0.045) in both groups, with a non-significant trend favoring curcumin (adjusted mean difference 2.85; 95 % CI −2.13–7.83).

Adjunctive curcumin nano-micelle therapy significantly reduced overall pruritus intensity in patients with refractory PBP. Sleep and QoL outcomes improved in both groups, with trends favoring curcumin. Larger, longer trials with optimized dosing are warranted to confirm these findings.

烧伤后瘙痒（PBP）是一种常见的难治性疾病，严重影响生活质量（QoL）。姜黄素是一种具有抗炎和神经保护作用的生物活性化合物，已被提出作为慢性瘙痒的治疗选择。本研究评估了姜黄素纳米胶束制剂在难治性PBP患者中的疗效。在这项随机对照试验中，100名患有PBP的成年人被分配接受单独的标准治疗或姜黄素纳米胶束胶囊（40 mg，每天两次），为期12周。结果包括瘙痒严重程度、频率、分布、睡眠状况、睡眠障碍、总瘙痒强度和生活质量（ItchyQoL），分别在基线、第6周和第12周进行评估。采用以组、时间和group×time为因素的混合效应模型进行分析。两组在某些瘙痒领域均表现出显著的组内改善。然而，在混合效应模型中，姜黄素使瘙痒总强度在组间显著降低（调整后的平均差为-2.83；95 % CI为-5.54至-0.11;p = 0.041）。个别领域未观察到显著的组间效应。姜黄素改善了睡眠状况（调整后的平均差值为-0.50；95 % CI为-1.04-0.03），但没有达到统计学意义。随着时间的推移，两组患者的生活质量均有显著改善（时间效应p = 0.045），姜黄素的改善趋势不显著（调整后平均差为2.85;95 % CI -2.13-7.83）。辅助姜黄素纳米胶束治疗可显著降低难治性PBP患者的瘙痒强度。两组患者的睡眠和生活质量均有改善，姜黄素的改善趋势更明显。有必要进行更大规模、更长时间的优化剂量试验，以证实这些发现。

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引用次数: 0

Global burden of pressure injuries in aging populations and cost - effectiveness analysis of intervention measures in China 老龄人群压力性损伤的全球负担及中国干预措施的成本-效果分析

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-10-28 DOI: 10.1016/j.burns.2025.107753

Xiu-Hang Zhang, Duo Cai, Jia-Ao Yu

Background

Pressure injuries remain a major preventable challenge in geriatric care, with their burden exacerbated by global population aging and inequities in healthcare access—particularly impacting low- and middle-income countries (LMICs) and vulnerable subgroups. Prior studies have focused on high-income regions or single-country cohorts, lacking comprehensive global analyses of burden trends and context-specific cost-effective interventions.

Objective

This study aimed to 1) analyze the spatiotemporal patterns of pressure injury-related disability burden among adults aged ≥ 65 years across 204 countries from 1990 to 2021; 2) project future burden trends through 2035 using Bayesian modeling; and 3) evaluate the cost-effectiveness of pressure injury prevention interventions (pressure-redistribution devices [PRDs] and caregiver training programs [CTPs]) in China’s aging cohort.

Methods

Data on disability-adjusted life years (DALYs) were extracted from the Global Burden of Disease (GBD) 2021 dataset via the Global Health Data Exchange (GHDx). Bayesian Age-Period-Cohort (BAPC) modeling with socioeconomic stratification (by Socio-Demographic Index, SDI) was used to estimate age-standardized DALY rates (ASDR) and project future burden. A probabilistic Markov decision model assessed the cost-effectiveness of standalone PRDs, standalone CTPs, and combined PRD+CTP interventions in China, incorporating local unit costs and GBD-derived disability weights.

Results

Between 1990 and 2021, absolute DALYs surged 130.8 % globally, though age-standardized rates showed modest decline. Sex disparities emerged: females accounted for 59 % of total DALYs in 2021, with slower ASDR declines [Estimated Annual Percentage Change (EAPC): −0.49 %] than males (EAPC: −0.75 %). In China, PRD+CTP interventions averted 231,840 DALYs yearly, saving $588 M in net healthcare costs over 5 years.

Conclusion

Global pressure injury burden in aging populations is growing, with stark regional and sex disparities. The combined PRD and CTP interventions represent a cost-effective strategy for mitigating disease burden in China, thus potentially offering a scalable framework for LMICs.

压力性损伤仍然是老年护理中一个主要可预防的挑战，全球人口老龄化和医疗保健获取不平等加剧了压力性损伤的负担，对低收入和中等收入国家（LMICs）和弱势亚群体的影响尤其严重。先前的研究主要集中在高收入地区或单一国家队列，缺乏对负担趋势的全面全球分析和针对具体情况的成本效益干预措施。目的：分析1990 - 2021年204个国家≥ 65岁成人压力性损伤相关残疾负担的时空格局；2)利用贝叶斯模型预测到2035年的未来负担趋势；3)评估压力伤害预防干预措施（压力再分配装置[PRDs]和护理人员培训计划[ctp]）在中国老龄化人群中的成本效益。方法通过全球健康数据交换（GHDx）从全球疾病负担（GBD） 2021数据集中提取残疾调整生命年（DALYs）数据。采用贝叶斯年龄-时期-队列（BAPC）模型和社会经济分层（通过社会人口指数，SDI）来估计年龄标准化的DALY率（ASDR）和预测未来负担。一个概率马尔可夫决策模型评估了中国单独的PRD、单独的CTP和PRD+CTP联合干预的成本效益，包括当地单位成本和gbd衍生的残疾权重。结果1990年至2021年间，全球范围内的DALYs绝对值飙升了130.8% %，尽管年龄标准化率略有下降。性别差异出现：女性占2021年DALYs总数的59% %，ASDR下降速度较男性慢[估计年度百分比变化（EAPC）：−0.49 %]（EAPC:−0.75 %）。在中国，PRD+CTP干预每年避免了231840个伤残调整年，在5年内节省了5.88 亿美元的净医疗成本。结论全球老年人压力性损伤负担不断增加，且存在明显的地区差异和性别差异。PRD和CTP相结合的干预措施是减轻中国疾病负担的一种具有成本效益的战略，因此有可能为中低收入国家提供可扩展的框架。

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引用次数: 0

Comment on “The effect of music therapy on background pain, anxiety, depression, vital signs, and medication usage in adult burn patients in the intensive care unit: A randomized controlled trial” 评论“音乐治疗对重症监护病房成人烧伤患者背景疼痛、焦虑、抑郁、生命体征和药物使用的影响：一项随机对照试验”。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-10-27 DOI: 10.1016/j.burns.2025.107756

Jianguo Wang, Qiang Guo, Hua Yan, Xiaoting Ye

引用次数: 0