Burn survivors can experience overlapping symptoms; identifying clusters may improve care. This study examined chronic symptom clusters six months post-burn and their predictors and psychosocial impacts.
Methods
Data from the Burn Model System (2015–2022) were analyzed using factor analysis of post-burn symptoms. Linear regression assessed associations between factor scores and psychosocial outcomes.
Results
The sample included 405 patients (66 % male; mean age 45.4; median burn size 14 % TBSA; 60.2 % fire/flame). A three-factor solution was identified: (1) Psychological distress (28 % variance) with high loadings for anxiety and depression, moderate for sleep disturbance; (2) Pain-related symptoms (22 %) with high pain interference and intensity, moderate fatigue; (3) Itch-related symptoms (16 %) with high itch interference, moderate itch intensity. Rehabilitation days were associated with all factors; surgeries with Factors 1 and 2. Women scored higher on Factor 1, while %TBSA predicted Factor 3. Higher Factor 1 scores were linked to poorer mental health, greater PTSD burden, and lower life satisfaction and higher Factor 2 scores to worse physical and mental health.
Conclusion
At six months post-burn, symptoms clustered into psychological distress, pain, and itch factors. Pain and distress, but not itch, were associated with poorer physical, mental, and social functioning.
{"title":"Pain, itch, and psychological distress symptom clusters in burn survivors: A factor analysis","authors":"Lynn Nakad , Arushi Biswas , Jeannie-Marie Leoutsakos , Rachel Kornhaber , Michelle Cleary , Julie A. Caffrey , Sheera F. Lerman","doi":"10.1016/j.burns.2025.107787","DOIUrl":"10.1016/j.burns.2025.107787","url":null,"abstract":"<div><h3>Background</h3><div>Burn survivors can experience overlapping symptoms; identifying clusters may improve care. This study examined chronic symptom clusters six months post-burn and their predictors and psychosocial impacts.</div></div><div><h3>Methods</h3><div>Data from the Burn Model System (2015–2022) were analyzed using factor analysis of post-burn symptoms. Linear regression assessed associations between factor scores and psychosocial outcomes.</div></div><div><h3>Results</h3><div>The sample included 405 patients (66 % male; mean age 45.4; median burn size 14 % TBSA; 60.2 % fire/flame). A three-factor solution was identified: (1) Psychological distress (28 % variance) with high loadings for anxiety and depression, moderate for sleep disturbance; (2) Pain-related symptoms (22 %) with high pain interference and intensity, moderate fatigue; (3) Itch-related symptoms (16 %) with high itch interference, moderate itch intensity. Rehabilitation days were associated with all factors; surgeries with Factors 1 and 2. Women scored higher on Factor 1, while %TBSA predicted Factor 3. Higher Factor 1 scores were linked to poorer mental health, greater PTSD burden, and lower life satisfaction and higher Factor 2 scores to worse physical and mental health.</div></div><div><h3>Conclusion</h3><div>At six months post-burn, symptoms clustered into psychological distress, pain, and itch factors. Pain and distress, but not itch, were associated with poorer physical, mental, and social functioning.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107787"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-09DOI: 10.1016/j.burns.2025.107822
Lily Zhu , Iman F. Khan , Rafael Felix P. Tiongco , Jeffrey Khong , Lisa C. Smith , Rena Atayeva , Tomer Lagziel , Carisa M. Cooney , Julie A. Caffrey
Introduction
Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting intertriginous skin. Severe HS presents a reconstructive challenge due to high complication rates; however, risk factors for complications are understudied. This study examines patient-level risk factors for increased complications and operative techniques used at our institution.
Methods
We conducted an IRB-approved retrospective review of patients (≥18 years) who underwent primary or secondary wide local excision of HS between 12/1/2015–06/02/2022. Sociodemographic, intraoperative, and complication data were analyzed using descriptive statistics and Fisher’s exact tests. Multiple logistic regression was used to determine the association between patient demographic factors and occurrence of any complications. Significance was set at p < 0.05.
Results
Of the 347 patients identified, 239 met inclusion criteria (median age 35 years, follow-up time 13 months). Most patients were Black (76 %) and non-Hispanic/non-Latino (95 %). Common HS risk factors included current smoking (20 %), former smoking (18 %), and diabetes (15 %). Patients were classified as Hurley Stage I (6 %), II (23 %), and III (45 %). Overall, 284 complications were reported, with more severe complications (e.g., flap/graft failure, hypertrophic granulation, keloid formation, hypertrophic scarring) predominantly occurring in Stage III. Complication rates of “other” complications differed significantly across Hurley stages I, II, and III (7 %, 2 %, 21 %, respectively; p < 0.01), with Stage III having the highest rates. Unplanned reoperations also demonstrated significant differences across stages (27 %, 4 %, 18 %, respectively; p = 0.01). Regression analysis showed White race was significantly associated with lower complication risk (p = 0.039), while prior immunomodulator use increased risk (p = 0.02).
Conclusions
Disease severity and demographic factors significantly impact HS surgical outcomes. Patients in Hurley Stage III experienced higher complication rates. White race was associated with decreased complication risk while prior immunomodulator use was associated with increased complication risk, suggesting sociodemographic disparities and disease complexity contribute to poorer post-operative outcomes.
{"title":"Looking beyond the scalpel: Assessing patient risk factors for complications following surgical excision of hidradenitis suppurativa","authors":"Lily Zhu , Iman F. Khan , Rafael Felix P. Tiongco , Jeffrey Khong , Lisa C. Smith , Rena Atayeva , Tomer Lagziel , Carisa M. Cooney , Julie A. Caffrey","doi":"10.1016/j.burns.2025.107822","DOIUrl":"10.1016/j.burns.2025.107822","url":null,"abstract":"<div><h3>Introduction</h3><div>Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting intertriginous skin. Severe HS presents a reconstructive challenge due to high complication rates; however, risk factors for complications are understudied. This study examines patient-level risk factors for increased complications and operative techniques used at our institution.</div></div><div><h3>Methods</h3><div>We conducted an IRB-approved retrospective review of patients (≥18 years) who underwent primary or secondary wide local excision of HS between 12/1/2015–06/02/2022. Sociodemographic, intraoperative, and complication data were analyzed using descriptive statistics and Fisher’s exact tests. Multiple logistic regression was used to determine the association between patient demographic factors and occurrence of any complications. Significance was set at p < 0.05.</div></div><div><h3>Results</h3><div>Of the 347 patients identified, 239 met inclusion criteria (median age 35 years, follow-up time 13 months). Most patients were Black (76 %) and non-Hispanic/non-Latino (95 %). Common HS risk factors included current smoking (20 %), former smoking (18 %), and diabetes (15 %). Patients were classified as Hurley Stage I (6 %), II (23 %), and III (45 %). Overall, 284 complications were reported, with more severe complications (e.g., flap/graft failure, hypertrophic granulation, keloid formation, hypertrophic scarring) predominantly occurring in Stage III. Complication rates of “other” complications differed significantly across Hurley stages I, II, and III (7 %, 2 %, 21 %, respectively; <em>p</em> < 0.01), with Stage III having the highest rates. Unplanned reoperations also demonstrated significant differences across stages (27 %, 4 %, 18 %, respectively; <em>p</em> = 0.01). Regression analysis showed White race was significantly associated with lower complication risk (<em>p</em> = 0.039), while prior immunomodulator use increased risk (<em>p</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>Disease severity and demographic factors significantly impact HS surgical outcomes. Patients in Hurley Stage III experienced higher complication rates. White race was associated with decreased complication risk while prior immunomodulator use was associated with increased complication risk, suggesting sociodemographic disparities and disease complexity contribute to poorer post-operative outcomes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107822"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-09DOI: 10.1016/j.burns.2025.107828
Jiapeng Deng , Kai Chen , Xiaoying Jin , Danna Chu , Chaoyang Qi
Purpose
Flap necrosis is a common postoperative complication primarily caused by ischemia-reperfusion injury and impaired angiogenesis. This study investigated the therapeutic effects and mechanisms of chrysin, a natural flavonoid compound extracted from medicinal plants including Oroxylum indicum, Scutellaria baicalensis, and Passiflora spp, on the survival of random skin flaps.
Methods
We employed network pharmacology to analyze chrysin's mechanism of action, predicting its therapeutic targets in ischemic diseases through cross-analysis of its potential targets with the pathophysiological mechanisms of ischemia-reperfusion injury. Molecular docking technology was used to simulate the optimal binding conformation and affinity between chrysin and its target receptors. Additionally, a modified McFarlane flap model was established in 36 Sprague-Dawley rats randomly divided into control, low-dose (10 mg/kg/day), and high-dose (40 mg/kg/day) groups (n = 12 each). Flap survival was evaluated 7 days postoperatively, along with assessments of TLR4/NF-κB/NLRP3 signaling pathway expression, tissue inflammation, oxidative stress levels, and blood perfusion.
Results
Chrysin treatment significantly improved flap survival rate in a dose-dependent manner. The mechanisms involved were 1) inhibiting activation of the TLR4/NF-κB/NLRP3 inflammatory signaling pathway; 2) reducing oxidative stress damage; and 3) promoting angiogenesis through upregulation of VEGF-A expression.
Conclusions
This study demonstrates that the plant-derived flavonoid chrysin improves flap survival through multiple mechanisms, including anti-inflammatory, antioxidant, and pro-angiogenic effects, providing a potential phytotherapeutic strategy for preventing and treating flap necrosis. These findings not only elucidate the pharmacological mechanisms of chrysin but also provide theoretical foundations for developing natural product-based adjuvant therapies in surgery.
{"title":"Chrysin promotes the survival of flaps through the TLR4/NF-κB/NLRP3 signaling pathway","authors":"Jiapeng Deng , Kai Chen , Xiaoying Jin , Danna Chu , Chaoyang Qi","doi":"10.1016/j.burns.2025.107828","DOIUrl":"10.1016/j.burns.2025.107828","url":null,"abstract":"<div><h3>Purpose</h3><div>Flap necrosis is a common postoperative complication primarily caused by ischemia-reperfusion injury and impaired angiogenesis. This study investigated the therapeutic effects and mechanisms of chrysin, a natural flavonoid compound extracted from medicinal plants including Oroxylum indicum, Scutellaria baicalensis, and Passiflora spp, on the survival of random skin flaps.</div></div><div><h3>Methods</h3><div>We employed network pharmacology to analyze chrysin's mechanism of action, predicting its therapeutic targets in ischemic diseases through cross-analysis of its potential targets with the pathophysiological mechanisms of ischemia-reperfusion injury. Molecular docking technology was used to simulate the optimal binding conformation and affinity between chrysin and its target receptors. Additionally, a modified McFarlane flap model was established in 36 Sprague-Dawley rats randomly divided into control, low-dose (10 mg/kg/day), and high-dose (40 mg/kg/day) groups (n = 12 each). Flap survival was evaluated 7 days postoperatively, along with assessments of TLR4/NF-κB/NLRP3 signaling pathway expression, tissue inflammation, oxidative stress levels, and blood perfusion.</div></div><div><h3>Results</h3><div>Chrysin treatment significantly improved flap survival rate in a dose-dependent manner. The mechanisms involved were 1) inhibiting activation of the TLR4/NF-κB/NLRP3 inflammatory signaling pathway; 2) reducing oxidative stress damage; and 3) promoting angiogenesis through upregulation of VEGF-A expression.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that the plant-derived flavonoid chrysin improves flap survival through multiple mechanisms, including anti-inflammatory, antioxidant, and pro-angiogenic effects, providing a potential phytotherapeutic strategy for preventing and treating flap necrosis. These findings not only elucidate the pharmacological mechanisms of chrysin but also provide theoretical foundations for developing natural product-based adjuvant therapies in surgery.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107828"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-04DOI: 10.1016/j.burns.2025.107767
Noor Obaidi , Kristo Nuutila , Jamie Neelon , Victoria Diaz , Kristin Anselmo , Rodney K. Chan
Background
Split-thickness skin grafting (STSG) is the standard of care for treating major skin loss but is associated with significant donor site morbidity, including pain, prolonged healing, hypertrophic scarring, and pigmentation changes. Full-thickness skin column (FTSC) grafting has emerged as an alternative approach to transplant autologous skin in the management of full-thickness wounds. This clinical study evaluated an electronic FTSC harvesting and application device called the Autologous Regeneration of Tissue (ART). The ART device is designed to harvest 316 FTSCs from a small donor area and transplant them onto the recipient site in just a few minutes.
Methods
A clinical study was conducted comparing donor site wounds created with the ART device to those created with a conventional dermatome to harvest STSGs. Patients with full-thickness wounds that required skin grafting were enrolled in the study. Donor sites using the ART device and a dermatome were created on each participant. The donor sites were followed for up to 60 days after harvesting and were assessed for inflammation, pain, healing, and scarring on days 3, 7, 14, 30, and 60.
Results
In total, the study included five patients, and five ART donor sites were compared with five STSG donor sites. The results showed that by day 7, all the ART donor sites were fully healed, while the STSG donor sites were near full closure (97 %) by day 14. Pain measured using the 0–10 visual analog scale (VAS) indicated significantly less pain in the ART donor sites on day 7. Quality of healing measures using both the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS) showed significantly less scarring in the ART donor sites on postoperative day and 60.
Conclusions
It was shown that the ART device was easy to use and enabled the harvesting of hundreds of FTSCs from a small donor area and their application onto the recipient site in just a couple of minutes. The ART donor site exhibited faster healing, reduced pain, and less inflammation and scarring. However, due to the small sample size, these results should be considered preliminary.
{"title":"Clinical study comparing full-thickness skin columns and split-thickness skin graft donor sites in terms of pain and healing outcomes","authors":"Noor Obaidi , Kristo Nuutila , Jamie Neelon , Victoria Diaz , Kristin Anselmo , Rodney K. Chan","doi":"10.1016/j.burns.2025.107767","DOIUrl":"10.1016/j.burns.2025.107767","url":null,"abstract":"<div><h3>Background</h3><div>Split-thickness skin grafting (STSG) is the standard of care for treating major skin loss but is associated with significant donor site morbidity, including pain, prolonged healing, hypertrophic scarring, and pigmentation changes. Full-thickness skin column (FTSC) grafting has emerged as an alternative approach to transplant autologous skin in the management of full-thickness wounds. This clinical study evaluated an electronic FTSC harvesting and application device called the Autologous Regeneration of Tissue (ART). The ART device is designed to harvest 316 FTSCs from a small donor area and transplant them onto the recipient site in just a few minutes.</div></div><div><h3>Methods</h3><div>A clinical study was conducted comparing donor site wounds created with the ART device to those created with a conventional dermatome to harvest STSGs. Patients with full-thickness wounds that required skin grafting were enrolled in the study. Donor sites using the ART device and a dermatome were created on each participant. The donor sites were followed for up to 60 days after harvesting and were assessed for inflammation, pain, healing, and scarring on days 3, 7, 14, 30, and 60.</div></div><div><h3>Results</h3><div>In total, the study included five patients, and five ART donor sites were compared with five STSG donor sites. The results showed that by day 7, all the ART donor sites were fully healed, while the STSG donor sites were near full closure (97 %) by day 14. Pain measured using the 0–10 visual analog scale (VAS) indicated significantly less pain in the ART donor sites on day 7. Quality of healing measures using both the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS) showed significantly less scarring in the ART donor sites on postoperative day and 60.</div></div><div><h3>Conclusions</h3><div>It was shown that the ART device was easy to use and enabled the harvesting of hundreds of FTSCs from a small donor area and their application onto the recipient site in just a couple of minutes. The ART donor site exhibited faster healing, reduced pain, and less inflammation and scarring. However, due to the small sample size, these results should be considered preliminary.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107767"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-07DOI: 10.1016/j.burns.2025.107772
Vanessa Heaslip , Sharon Docherty , Shelley Rhodes , Ukoumunne Obioha , Katie Breheny , Kate Attrill , Jonathon Pleat , Mark P. Brewin
Background
Due to improvements in acute burn management, burn injuries are a leading cause of morbidity globally. Alongside physical sequelae of burns, there are significant psychological implications. Limited qualitative research exists exploring quality of life (QoL) and delayed reintegration into society; the latter is argued as the greatest unmet challenge in burn rehabilitation. Furthermore, there is a lack of research into non-scar outcomes after pulse dye laser (PDL) treatment of burn scars. This qualitative study examines the patient’s experience of early PDL treatment and its impact upon QoL and social reintegration.
Methods
This qualitative study is nested within a national, multicentre, parallel-arm randomised controlled trial (RCT) across seven National Health Service hospitals in the United Kingdom (Early Laser for Burn Scars (ELABS), Trial registration ISRCTN14392301). The Consolidated Criteria for Reporting Qualitative Studies were used. Of the 153 participants in the trial, 34 were approached across a range of demographic, burn and site criteria including: gender, age, burn location, depth, total body surface area (TBSA), skin type, site location, and treatment arm. Data was collected using semi-structured telephone interviews. reflexive thematic analysis was used to analyse the transcribed data.
Results
20 participants were interviewed. Six themes were constructed: frustration with initial burns treatment, feeling disconnected, human costs (with three sub themes: having to adapt, it’s changed how I feel about myself, and it doesn’t just affect me), money worries, reflections on pulse dye laser treatment, and moving forwards.
Conclusion
The scar management journey is long and complex due to significant physical, psychological, financial, and psychosocial impacts. These can negatively affect QoL and reintegration into society. Use of early PDL treatment can ameliorate these challenges by positively impacting upon QoL and supporting individuals whilst they create their ‘new normal’ and adjust to reintegration into society.
{"title":"Patients’ experiences of treatment and the scar management pathway during the Early Laser for Burn Scars (ELABS) trial: An embedded qualitative study","authors":"Vanessa Heaslip , Sharon Docherty , Shelley Rhodes , Ukoumunne Obioha , Katie Breheny , Kate Attrill , Jonathon Pleat , Mark P. Brewin","doi":"10.1016/j.burns.2025.107772","DOIUrl":"10.1016/j.burns.2025.107772","url":null,"abstract":"<div><h3>Background</h3><div>Due to improvements in acute burn management, burn injuries are a leading cause of morbidity globally. Alongside physical sequelae of burns, there are significant psychological implications. Limited qualitative research exists exploring quality of life (QoL) and delayed reintegration into society; the latter is argued as the greatest unmet challenge in burn rehabilitation. Furthermore, there is a lack of research into non-scar outcomes after pulse dye laser (PDL) treatment of burn scars. This qualitative study examines the patient’s experience of early PDL treatment and its impact upon QoL and social reintegration.</div></div><div><h3>Methods</h3><div>This qualitative study is nested within a national, multicentre, parallel-arm randomised controlled trial (RCT) across seven National Health Service hospitals in the United Kingdom (Early Laser for Burn Scars (ELABS), Trial registration ISRCTN14392301). The Consolidated Criteria for Reporting Qualitative Studies were used. Of the 153 participants in the trial, 34 were approached across a range of demographic, burn and site criteria including: gender, age, burn location, depth, total body surface area (TBSA), skin type, site location, and treatment arm. Data was collected using semi-structured telephone interviews. reflexive thematic analysis was used to analyse the transcribed data.</div></div><div><h3>Results</h3><div>20 participants were interviewed. Six themes were constructed: frustration with initial burns treatment, feeling disconnected, human costs (with three sub themes: having to adapt, it’s changed how I feel about myself, and it doesn’t just affect me), money worries, reflections on pulse dye laser treatment, and moving forwards.</div></div><div><h3>Conclusion</h3><div>The scar management journey is long and complex due to significant physical, psychological, financial, and psychosocial impacts. These can negatively affect QoL and reintegration into society. Use of early PDL treatment can ameliorate these challenges by positively impacting upon QoL and supporting individuals whilst they create their ‘new normal’ and adjust to reintegration into society.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107772"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-19DOI: 10.1016/j.burns.2025.107788
Peng Han, Jie Zhang, Yunpeng Ma
Background
The pathogenesis of keloids is still unclear and effective biomarkers are lacking. Therefore, it is urgent to find clinically effective biomarkers and study their regulatory mechanisms.
Methods
Candidate genes were screened by amplifying RNA methylation-related gene modules by weighted correlation network analysis and intersecting them with differentially expressed genes in the GSE145725 dataset. After Mendelian randomisation, machine learning and gene expression validation, keloid prediction models were constructed. Subsequently, genomic enrichment analysis, immune infiltration, GeneMANIA analysis, molecular network and drug prediction were performed, and biomarker function was explored using single-cell datasets. Finally, biomarker expression in clinical samples was validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR).
Results
A total of two biomarkers (PEAR1 and MAPKAPK3) were identified and the disease prediction model performed well. They were mainly involved in the proteasomal and ribosomal pathways and were associated with myeloid dendritic cells and resting T CD4 + memory cells. In addition, fibroblasts were identified as key cells expressing PEAR1 and MAPKAPK3. RT-qPCR confirmed that the expression of both biomarkers was downregulated in the keloid group, consistent with the results of differential expression analysis.
Conclusion
This study suggests that PEAR1 and MAPKAPK3 may contribute to keloid formation and provides insights for subsequent functional studies.
{"title":"Uncovering and validating biomarkers associated with RNA methylation modifications in keloids: Insights from transcriptomic and Mendelian randomization analyses","authors":"Peng Han, Jie Zhang, Yunpeng Ma","doi":"10.1016/j.burns.2025.107788","DOIUrl":"10.1016/j.burns.2025.107788","url":null,"abstract":"<div><h3>Background</h3><div>The pathogenesis of keloids is still unclear and effective biomarkers are lacking. Therefore, it is urgent to find clinically effective biomarkers and study their regulatory mechanisms.</div></div><div><h3>Methods</h3><div>Candidate genes were screened by amplifying RNA methylation-related gene modules by weighted correlation network analysis and intersecting them with differentially expressed genes in the GSE145725 dataset. After Mendelian randomisation, machine learning and gene expression validation, keloid prediction models were constructed. Subsequently, genomic enrichment analysis, immune infiltration, GeneMANIA analysis, molecular network and drug prediction were performed, and biomarker function was explored using single-cell datasets. Finally, biomarker expression in clinical samples was validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR).</div></div><div><h3>Results</h3><div>A total of two biomarkers (PEAR1 and MAPKAPK3) were identified and the disease prediction model performed well. They were mainly involved in the proteasomal and ribosomal pathways and were associated with myeloid dendritic cells and resting T CD4 + memory cells. In addition, fibroblasts were identified as key cells expressing PEAR1 and MAPKAPK3. RT-qPCR confirmed that the expression of both biomarkers was downregulated in the keloid group, consistent with the results of differential expression analysis.</div></div><div><h3>Conclusion</h3><div>This study suggests that PEAR1 and MAPKAPK3 may contribute to keloid formation and provides insights for subsequent functional studies.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107788"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-01DOI: 10.1016/j.burns.2025.107757
Nanru Peng, Xinzhi Peng
{"title":"Comments on \"The impact of negative pressure wound therapy on epidermal stem cells and keratinocyte growth factor in deep dermal burn injury: An experimental study\"","authors":"Nanru Peng, Xinzhi Peng","doi":"10.1016/j.burns.2025.107757","DOIUrl":"10.1016/j.burns.2025.107757","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107757"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-19DOI: 10.1016/j.burns.2025.107781
Leopoldo C. Cancio, Kaitlin A. Pruskowski
{"title":"Historical note: The research strategy that halved postburn mortality","authors":"Leopoldo C. Cancio, Kaitlin A. Pruskowski","doi":"10.1016/j.burns.2025.107781","DOIUrl":"10.1016/j.burns.2025.107781","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107781"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-22DOI: 10.1016/j.burns.2025.107838
Mengfan Zhai, Hui Wang
{"title":"Comment on “Evaluating the association between bronchoscopic severity of burns-related smoke inhalation injury and clinical outcomes: A systematic review and meta-analysis”","authors":"Mengfan Zhai, Hui Wang","doi":"10.1016/j.burns.2025.107838","DOIUrl":"10.1016/j.burns.2025.107838","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107838"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-28DOI: 10.1016/j.burns.2025.107815
Rachel Nzungize , Cameron Gibson , Eléazar Ndabarora , Bernard Umutoniwase , Ronald Tubasiime
Introduction
Burns are the fourth most common type of injury presenting to emergency departments in Rwanda; however, research related to the epidemiology of burn injuries is limited. The objectives of this study were to investigate the epidemiology and treatment of burns in a rural region of Rwanda to better inform local public health initiatives.
Methods
Data collection took place at Kibogora Level Two Teaching Hospital in the Western Province of Rwanda from July 2023 to November 2024. Patients enrolled in the study included all burn patients who presented to the hospital during the study period. Data were collected through patient interviews and electronic medical records using a standardized form.
Results
Eighty burn patients presented to the hospital during the study period. Children most often presented with burn injuries, with 70 % (n = 56) of the study population being 0–15 years old. Scald was the most common type of burn (n = 60, 75 %). Burns were mostly related to cooking activities (n = 60, 75 %). Traditional medicine was used as first aid in 57.5 % (n = 46) of the cases. Time from injury to treatment was > 24 h in 32.5 % (n = 26) of the patients. Complications were common at 43.8 % (n = 35), with the most frequent type being burn wound infection (n = 30, 37.5 %). All patients survived their burn injuries.
Conclusion
Prevention efforts should prioritize reaching children and their caregivers while highlighting kitchen safety and the dangers of hot liquids that can cause scald burn injuries. Burn wound infection prevention is also a priority for education.
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