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Comment on: “The effect of robot-assisted training on burn rehabilitation: A systematic review and meta-analysis” 评论:“机器人辅助训练对烧伤康复的影响:系统回顾和荟萃分析”
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-19 DOI: 10.1016/j.burns.2025.107835
Wangqi Tan
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引用次数: 0
How deep does it really burn? Social and emotional implications of paediatric burn injuries and care on Aboriginal and Torres Strait Islander families 它到底能烧多深?土著和托雷斯海峡岛民家庭的儿童烧伤和护理的社会和情感影响
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.burns.2025.107837
Hayley M. Williams , Kate Hunter , Bronwyn Griffin , Roy Kimble , Kathleen Clapham

Background

Paediatric burns are highly painful and traumatic injuries that affect Aboriginal and Torres Strait Islander children at disproportionate rates, yet their experiences are often omitted from burns research. This study aimed to better understand the social and emotional impacts and unmet support needs that paediatric burn injuries and care cause Aboriginal and Torres Strait Islander families.

Methods

This decolonial ethnographic study followed 20 Aboriginal and Torres Strait Islander families’ experiences of paediatric burns care at a tertiary hospital in Queensland, Australia. Three methods were combined, including participant observations of burns care appointments/procedures (n = 54); retrospective thinking aloud sessions with burn specialists (n = 62); and yarning sessions with families (n = 14). Grounded theory analysis was conducted and triangulated for in-depth explorations of each family’s experiences.

Results

Paediatric burn injuries and care cause profound and prolonged social and emotional impacts for all members of Aboriginal and Torres Strait Islander families. These include, but are not limited to, panic, shock, distress, guilt, and fear; along with social isolation, family disruptions, physical implications, and financial and food insecurities. These burdens were worsened when burns care was uncollaborative, culturally unsafe, and included minimal supports.

Discussion

Paediatric burn specialists play vital roles in supporting Aboriginal and Torres Strait Islander families throughout burns care and beyond. However, several barriers continue to hinder their ability to provide collaborative and culturally and trauma-responsive care. There is a strong need for burns care to incorporate routine mental health screening, and cultural and mental health supports for all members of Aboriginal and Torres Strait Islander families.
儿童烧伤是非常痛苦和创伤性的伤害,以不成比例的比例影响土著和托雷斯海峡岛民儿童,然而他们的经历经常在烧伤研究中被忽略。本研究旨在更好地了解原住民和托雷斯海峡岛民家庭在儿童烧伤和护理方面的社会和情感影响以及未满足的支持需求。方法:本非殖民化人种学研究追踪了澳大利亚昆士兰州一家三级医院20个土著和托雷斯海峡岛民家庭的儿科烧伤护理经历。三种方法相结合,包括烧伤护理预约/程序的参与者观察(n = 54);与烧伤专家进行回顾性大声思考会议( = 62);和家人一起编纱线(n = 14)。对每个家庭的经历进行了扎实的理论分析和三角化的深入探索。结果儿科烧伤及其护理对原住民和托雷斯海峡岛民家庭的所有成员产生了深远而持久的社会和情感影响。这些症状包括但不限于恐慌、震惊、痛苦、内疚和恐惧;伴随着社会孤立、家庭破裂、身体影响以及经济和粮食不安全。当烧伤护理缺乏合作、文化上不安全、支持最少时,这些负担会加重。儿科烧伤专家在支持原住民和托雷斯海峡岛民家庭整个烧伤护理及其他方面发挥着至关重要的作用。然而,一些障碍继续阻碍他们提供协作和文化和创伤反应性护理的能力。强烈需要将烧伤护理纳入常规心理健康检查,并为土著和托雷斯海峡岛民家庭的所有成员提供文化和心理健康支持。
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引用次数: 0
Comment on: “Effect of nature-based sounds on pain and anxiety during dressing changes in hospitalized burn patients: A randomized controlled clinical trial” 评论:“基于自然的声音对住院烧伤患者换药期间疼痛和焦虑的影响:一项随机对照临床试验”
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-17 DOI: 10.1016/j.burns.2025.107834
Shuxuan Li, Xinxia Lv, Guang Yang
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引用次数: 0
Burned for the likes: A comparative study of train surfing injuries, high-voltage trauma, and social media perspectives 为喜欢而燃烧:火车冲浪伤害,高压创伤和社交媒体视角的比较研究。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-16 DOI: 10.1016/j.burns.2025.107833
Luzie Hofmann , Aijia Cai , Tabea Breckwoldt, Gregory Reid, Lukas Naef, Mauro Vasella, Jennifer A. Watson, Bong-Sung Kim

Background

This study presents the clinical course of train surfing (TS) high-voltage (HV) injuries versus other HV burn victims (non-TS, NT) in Switzerland and explores the potential role of social media in promoting this risky behavior.

Methods

HV accidents involving unauthorized individuals on railroad tracks from 2016 to 2023 were retrospectively collected from the Federal Office of Transport (FOT) and the Swiss Transportation Safety Investigation Board (STSB). Additionally, clinical data of TS and NT patients treated at the University Hospital Zurich (USZ) Burn Center during 2016–2024 were retrospectively analyzed to compare injury severity, clinical course, and healthcare costs. An exploratory social media content analysis was also conducted to assess the potential influence of TS trends on TikTok and Instagram on the behavior’s popularity and perception.

Results

The FOT and STSB recorded 29 train-related HV accidents. 41 HV patients were treated at USZ, including 12 TS patients. TS were younger (43.6 vs. 20.3 years) and suffered more severe injuries (18.5 % vs. 44.3 % burned total body surface area, TBSA), higher rates secondary injuries (100 % vs. 31 %), longer ICU stays (48.5 vs. 13.2 days), and more complications (100 % vs. 58.6 %) than NT patients. As a result, rehabilitation time and hospitalization costs increased for TS (109 vs. 73 days and CHF 503 152 vs. CHF 174 307). Social media analysis revealed that TS-related content was popular and often glamorized the activity, with safety warnings frequently bypassed, potentially contributing to increased engagement in this risky behavior.

Conclusion

TS causes worse outcomes and higher medical costs compared to NT. Review of social media posts suggested that TS-related content achieved high visibility (measured by views, likes, and shares) and was often portrayed in an appealing or thrill-seeking manner, hence ‘glamorized’ the activity. This underscores the urgent need for targeted prevention and awareness efforts to reduce these avoidable injuries.
背景:本研究介绍了瑞士火车冲浪(TS)高压(HV)损伤与其他HV烧伤受害者(非TS, NT)的临床过程,并探讨了社交媒体在促进这种危险行为中的潜在作用。方法:回顾性收集2016年至2023年联邦交通局(FOT)和瑞士运输安全调查委员会(STSB)的铁路轨道上涉及未经授权人员的HV事故。此外,回顾性分析2016-2024年在苏黎世大学医院(USZ)烧伤中心治疗的TS和NT患者的临床数据,比较损伤严重程度、临床病程和医疗费用。我们还进行了探索性的社交媒体内容分析,以评估TikTok和Instagram上的TS趋势对该行为的受欢迎程度和认知度的潜在影响。结果:FOT和STSB共记录了29起与列车相关的高压事故。41例HV患者在USZ接受治疗,其中12例为TS患者。TS患者更年轻(43.6岁对20.3岁),损伤更严重(18.5% %对44.3% %烧伤总体表面积,TBSA),继发性损伤发生率更高(100 %对31. %),ICU住院时间更长(48.5天对13.2天),并发症更多(100 %对58.6 %)。结果,TS患者的康复时间和住院费用增加(109天对73天,503 152瑞士法郎对174 307瑞士法郎)。社交媒体分析显示,与ts相关的内容很受欢迎,而且经常美化这项活动,安全警告经常被忽略,这可能会增加人们对这种危险行为的参与。结论:与NT相比,TS会导致更糟糕的结果和更高的医疗费用。对社交媒体帖子的回顾表明,TS相关内容获得了很高的知名度(以浏览量、点赞和分享来衡量),并且经常以吸引人或寻求刺激的方式被描绘出来,因此“美化”了这项活动。这强调了迫切需要有针对性的预防和认识工作,以减少这些可避免的伤害。
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引用次数: 0
Comments on: “Evaluation of the effect of post-burn pruritus on patients’ quality of life and experiences” 评论:《烧伤后瘙痒对患者生活质量和体验的影响评价》
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-15 DOI: 10.1016/j.burns.2025.107832
Runze Zhang , Chenlu Zhao , Maocan Tao
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引用次数: 0
Fire safety measures in commercial complex residents: Application of protection motivation theory 商业综合体居民的消防安全措施:保护动机理论的应用。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.burns.2025.107830
Mohammadreza Shokouhi , Fahimeh Ramezani , Ali Fardi , Maryam Afshari , Salman Khazaei , Forouzan Rezapur-Shahkolai

Background

Fires in commercial buildings are of particular concern given their essential role in economic and social development. While fire safety research has often emphasized structural aspects of buildings, comparatively less attention has been paid to residents’ behavioral responses during fire incidents. Moreover, a considerable portion of the existing literature on fire safety lacks a robust theoretical foundation. To address this gap, the present study applies the Protection Motivation Theory (PMT) to examine factors influencing fire prevention behaviors among residents of commercial complexes.

Materials and methods

This cross-sectional study was conducted between September and December 2024 among 910 residents of commercial complexes in Hamadan. Participants were selected using a stratified sampling method based on complex size, followed by simple random sampling for individual inclusion. Data were collected through structured interviews with a questionnaire consisting of two sections: demographic and background information, and constructs derived from the PMT.

Results

The mean age of participants was 41.6 years, with an average of 7.6 working hours per day. Most participants were male (81.2 %) and had a middle school level of education (52.2 %). Nearly 12.2 % reported previous experience with a fire incident. In addition, higher scores of perceived susceptibility, perceived severity, fear, self-efficacy, response efficacy, perceived rewards, and protection motivation were associated with increased engagement in preventive measures. Daily working hours were also found to have a statistically significant correlation with the adoption of protective behaviors against fire in commercial buildings.

Conclusion

The findings of this study highlight the critical importance of fire prevention among individuals working in commercial complexes, given their unique occupational conditions. To ensure effective planning and implementation of preventive and intervention programs, it is essential to comprehensively identify the determinants of protective behaviors.
背景:商业建筑火灾在经济和社会发展中发挥着重要作用,因此受到特别关注。虽然消防安全研究经常强调建筑物的结构方面,但相对较少关注居民在火灾事件中的行为反应。此外,相当一部分现有的关于消防安全的文献缺乏坚实的理论基础。为了弥补这一空白,本研究运用保护动机理论(PMT)研究商业综合体居民防火行为的影响因素。材料与方法:本横断面研究于2024年9月至12月在哈马丹商业综合体的910名居民中进行。采用基于复杂尺寸的分层抽样方法选择参与者,然后进行简单随机抽样以进行个体纳入。数据通过结构化访谈收集,问卷包括两个部分:人口统计和背景信息,以及来自PMT的结构。结果:参与者的平均年龄为41.6岁,平均每天工作7.6小时。大多数参与者为男性(81.2 %),受教育程度为中学(52.2% %)。近12.2 %的人报告有过火灾事故的经历。此外,感知易感性、感知严重性、恐惧、自我效能、反应效能、感知奖励和保护动机得分较高,与参与预防措施的增加有关。每日工作时间也被发现与商业建筑防火保护行为的采用有统计学上的显著相关。结论:本研究的结果强调了在商业综合体中工作的个人,鉴于其独特的职业条件,防火的重要性。为了确保有效规划和实施预防和干预方案,必须全面确定保护性行为的决定因素。
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引用次数: 0
Identifying risk and protective factors for burn wound infection: A retrospective study 识别烧伤创面感染的危险因素和保护因素:一项回顾性研究
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-09 DOI: 10.1016/j.burns.2025.107826
Noah Borges , Soetkin Rapol , Ignace De Decker , Liesbet De Bus , Pieter Depuydt , Stan Monstrey , Karel E.Y. Claes , Jan Fierens

Background

Severe burn injuries remain associated with high morbidity and mortality due to secondary complications such as burn wound infections (BWIs). However, understanding of risk and protective factors for BWIs remains limited.

Methods

This retrospective cohort study included burn patients admitted to Ghent University Hospital between 2013 and 2023. Comorbidities, demographics, severity-of-illness scores, burn characteristics, and patient flow parameters were analysed. Penalised logistic regression and Cox survival analysis were performed. Patients without BWI served as controls.

Results

Among 492 burn patients, 68 (13.8 %) developed BWI, with a median onset of 4.7 days (IQR: 3.0–7.7). Penalised logistic regression identified vascular disease (aOR: 4.82, 95 % CI: [1.68–13.88], p = 0.005), age (p = 0.001), full-thickness burns (aOR: 3.26, 95 % CI: [1.55–6.89], p = 0.002) and TBSA (p < 0.001) as independent risk factors. In Cox models, debridement performed early after admission (days 2–4) was associated with a lower hazard of BWI, with no significant difference from day 5 onwards.

Conclusion

This study underscores the association between vascular disease, age, TBSA, and full-thickness burns with BWI. Early debridement (within days 2–4 of admission) was significantly associated with reduced BWI hazard. These findings may provide valuable insights for refining early burn care and treatment protocols.
背景:由于烧伤创面感染(BWIs)等继发性并发症,严重烧伤仍然具有高发病率和死亡率。然而,对BWIs的风险和保护因素的了解仍然有限。方法回顾性队列研究纳入2013年至2023年根特大学医院收治的烧伤患者。分析合并症、人口统计学、疾病严重程度评分、烧伤特征和患者流量参数。进行惩罚逻辑回归和Cox生存分析。无BWI患者作为对照组。结果492例烧伤患者中,68例(13.8 %)发生BWI,中位发病时间为4.7 d (IQR: 3.0 ~ 7.7)。惩罚逻辑回归确定血管疾病(优势比:4.82,95 % CI: [1.68 - -13.88], p = 0.005)、年龄(p = 0.001)、全层燃烧(优势比:3.26,95 % CI: [1.55 - -6.89], p = 0.002)和回溯(p & lt; 0.001)作为独立的危险因素。在Cox模型中,入院后早期(2-4天)进行清创与BWI的风险较低相关,从第5天开始没有显著差异。结论本研究强调了血管疾病、年龄、TBSA和BWI全层烧伤之间的关系。早期清创(入院后2-4天内)与BWI风险降低显著相关。这些发现可能为完善早期烧伤护理和治疗方案提供有价值的见解。
{"title":"Identifying risk and protective factors for burn wound infection: A retrospective study","authors":"Noah Borges ,&nbsp;Soetkin Rapol ,&nbsp;Ignace De Decker ,&nbsp;Liesbet De Bus ,&nbsp;Pieter Depuydt ,&nbsp;Stan Monstrey ,&nbsp;Karel E.Y. Claes ,&nbsp;Jan Fierens","doi":"10.1016/j.burns.2025.107826","DOIUrl":"10.1016/j.burns.2025.107826","url":null,"abstract":"<div><h3>Background</h3><div>Severe burn injuries remain associated with high morbidity and mortality due to secondary complications such as burn wound infections (BWIs). However, understanding of risk and protective factors for BWIs remains limited.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included burn patients admitted to Ghent University Hospital between 2013 and 2023. Comorbidities, demographics, severity-of-illness scores, burn characteristics, and patient flow parameters were analysed. Penalised logistic regression and Cox survival analysis were performed. Patients without BWI served as controls.</div></div><div><h3>Results</h3><div>Among 492 burn patients, 68 (13.8 %) developed BWI, with a median onset of 4.7 days (IQR: 3.0–7.7). Penalised logistic regression identified vascular disease (aOR: 4.82, 95 % CI: [1.68–13.88], p = 0.005), age (p = 0.001), full-thickness burns (aOR: 3.26, 95 % CI: [1.55–6.89], p = 0.002) and TBSA (p &lt; 0.001) as independent risk factors. In Cox models, debridement performed early after admission (days 2–4) was associated with a lower hazard of BWI, with no significant difference from day 5 onwards.</div></div><div><h3>Conclusion</h3><div>This study underscores the association between vascular disease, age, TBSA, and full-thickness burns with BWI. Early debridement (within days 2–4 of admission) was significantly associated with reduced BWI hazard. These findings may provide valuable insights for refining early burn care and treatment protocols.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107826"},"PeriodicalIF":2.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Looking beyond the scalpel: Assessing patient risk factors for complications following surgical excision of hidradenitis suppurativa 超越手术刀:评估化脓性汗腺炎手术切除后并发症的患者危险因素。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-09 DOI: 10.1016/j.burns.2025.107822
Lily Zhu , Iman F. Khan , Rafael Felix P. Tiongco , Jeffrey Khong , Lisa C. Smith , Rena Atayeva , Tomer Lagziel , Carisa M. Cooney , Julie A. Caffrey

Introduction

Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting intertriginous skin. Severe HS presents a reconstructive challenge due to high complication rates; however, risk factors for complications are understudied. This study examines patient-level risk factors for increased complications and operative techniques used at our institution.

Methods

We conducted an IRB-approved retrospective review of patients (≥18 years) who underwent primary or secondary wide local excision of HS between 12/1/2015–06/02/2022. Sociodemographic, intraoperative, and complication data were analyzed using descriptive statistics and Fisher’s exact tests. Multiple logistic regression was used to determine the association between patient demographic factors and occurrence of any complications. Significance was set at p < 0.05.

Results

Of the 347 patients identified, 239 met inclusion criteria (median age 35 years, follow-up time 13 months). Most patients were Black (76 %) and non-Hispanic/non-Latino (95 %). Common HS risk factors included current smoking (20 %), former smoking (18 %), and diabetes (15 %). Patients were classified as Hurley Stage I (6 %), II (23 %), and III (45 %). Overall, 284 complications were reported, with more severe complications (e.g., flap/graft failure, hypertrophic granulation, keloid formation, hypertrophic scarring) predominantly occurring in Stage III. Complication rates of “other” complications differed significantly across Hurley stages I, II, and III (7 %, 2 %, 21 %, respectively; p < 0.01), with Stage III having the highest rates. Unplanned reoperations also demonstrated significant differences across stages (27 %, 4 %, 18 %, respectively; p = 0.01). Regression analysis showed White race was significantly associated with lower complication risk (p = 0.039), while prior immunomodulator use increased risk (p = 0.02).

Conclusions

Disease severity and demographic factors significantly impact HS surgical outcomes. Patients in Hurley Stage III experienced higher complication rates. White race was associated with decreased complication risk while prior immunomodulator use was associated with increased complication risk, suggesting sociodemographic disparities and disease complexity contribute to poorer post-operative outcomes.
摘要化脓性汗腺炎(HS)是一种累及三叶间皮肤的慢性炎症性疾病。由于并发症发生率高,严重的HS提出了重建的挑战;然而,并发症的危险因素尚未得到充分研究。本研究探讨了患者水平的并发症增加的危险因素和我们机构使用的手术技术。方法:我们对2015年12月1日至2022年6月2日期间接受原发性或继发性HS大面积局部切除术的患者(≥18岁)进行了一项经irb批准的回顾性研究。采用描述性统计和Fisher精确检验对社会人口学、术中和并发症数据进行分析。采用多元逻辑回归来确定患者人口统计学因素与并发症发生之间的关系。结果:确定的347例患者中,239例符合纳入标准(中位年龄35岁,随访时间13个月)。大多数患者为黑人(76% %)和非西班牙裔/非拉丁裔(95% %)。常见的HS危险因素包括目前吸烟(20% %)、曾经吸烟(18% %)和糖尿病(15% %)。患者分为Hurley期(6 %)、期(23 %)和期(45 %)。总的来说,报告了284例并发症,更严重的并发症(如皮瓣/移植物失败,肥厚性肉芽肿,瘢痕疙瘩形成,肥厚性疤痕)主要发生在III期。Hurley期I、II、III期“其他”并发症发生率差异显著(分别为7 %、2 %、21 %);p 结论:疾病严重程度和人口统计学因素显著影响HS手术结果。Hurley III期患者的并发症发生率较高。白人与并发症风险降低相关,而先前使用免疫调节剂与并发症风险增加相关,这表明社会人口统计学差异和疾病复杂性导致较差的术后结果。
{"title":"Looking beyond the scalpel: Assessing patient risk factors for complications following surgical excision of hidradenitis suppurativa","authors":"Lily Zhu ,&nbsp;Iman F. Khan ,&nbsp;Rafael Felix P. Tiongco ,&nbsp;Jeffrey Khong ,&nbsp;Lisa C. Smith ,&nbsp;Rena Atayeva ,&nbsp;Tomer Lagziel ,&nbsp;Carisa M. Cooney ,&nbsp;Julie A. Caffrey","doi":"10.1016/j.burns.2025.107822","DOIUrl":"10.1016/j.burns.2025.107822","url":null,"abstract":"<div><h3>Introduction</h3><div>Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting intertriginous skin. Severe HS presents a reconstructive challenge due to high complication rates; however, risk factors for complications are understudied. This study examines patient-level risk factors for increased complications and operative techniques used at our institution.</div></div><div><h3>Methods</h3><div>We conducted an IRB-approved retrospective review of patients (≥18 years) who underwent primary or secondary wide local excision of HS between 12/1/2015–06/02/2022. Sociodemographic, intraoperative, and complication data were analyzed using descriptive statistics and Fisher’s exact tests. Multiple logistic regression was used to determine the association between patient demographic factors and occurrence of any complications. Significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Of the 347 patients identified, 239 met inclusion criteria (median age 35 years, follow-up time 13 months). Most patients were Black (76 %) and non-Hispanic/non-Latino (95 %). Common HS risk factors included current smoking (20 %), former smoking (18 %), and diabetes (15 %). Patients were classified as Hurley Stage I (6 %), II (23 %), and III (45 %). Overall, 284 complications were reported, with more severe complications (e.g., flap/graft failure, hypertrophic granulation, keloid formation, hypertrophic scarring) predominantly occurring in Stage III. Complication rates of “other” complications differed significantly across Hurley stages I, II, and III (7 %, 2 %, 21 %, respectively; <em>p</em> &lt; 0.01), with Stage III having the highest rates. Unplanned reoperations also demonstrated significant differences across stages (27 %, 4 %, 18 %, respectively; <em>p</em> = 0.01). Regression analysis showed White race was significantly associated with lower complication risk (<em>p</em> = 0.039), while prior immunomodulator use increased risk (<em>p</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>Disease severity and demographic factors significantly impact HS surgical outcomes. Patients in Hurley Stage III experienced higher complication rates. White race was associated with decreased complication risk while prior immunomodulator use was associated with increased complication risk, suggesting sociodemographic disparities and disease complexity contribute to poorer post-operative outcomes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107822"},"PeriodicalIF":2.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of COVID-19 on patterns of burns evaluated in pediatric emergency departments COVID-19对儿科急诊科烧伤模式的影响
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-09 DOI: 10.1016/j.burns.2025.107823
Stephanie Ruest , Laurie H. Johnson , Katherine T. Flynn-O’Brien , Christina Georgeades , Holly R. Hanson , Andrew W. Kiragu , Michelle T. Ruda , Mark R. Zonfrillo , Wendy J. Pomerantz

Background

Fire- and burn-related injuries are among the top 10 causes of death for children < 18 years in the United States and are associated with significant morbidity. Data regarding the impact of the COVID-19 pandemic on pediatric burns in emergency department (ED) settings are limited.

Objective

To examine differences in pediatric burn-related injury patterns before and during the COVID-19 pandemic.

Methods

This is a subanalysis of a multi-center cross-sectional study of 741,418 injury-related visits to 40 pediatric EDs for children < 18 years. Burn visits were identified by International Classification of Diseases, 10th Revision (ICD-10) codes. Patient demographics and burn-related injury patterns for 3/17/2019–12/31/2019 (control period) vs. 3/15/2020–12/31/2020 (pandemic study period) were compared.

Results

Burn-related visits comprised 2.2 % (N = 12,908) of all injury visits. In 2020 there were 3.7 % fewer burn visits, but the proportion of burn visits relative to other injuries was higher (2.5 % vs. 2.0 %, p < 0.001). There were significant differences in burn visits in 2020 by race (p < 0.05) and ethnicity (p = 0.01), with higher proportions of White and non-Hispanic patients. There were significant differences in the geographic distribution of burn visits in 2020 (p < 0.001) and significantly higher proportions of more urgent triage levels (p <0.05) and trauma activations (p < 0.05). Body region affected (p < 0.01), intent (p < 0.001) and mechanism (p < 0.001) also differed significantly. A higher proportion were due to flames/fires and fewer due to hot objects.

Conclusions

Burns comprised a higher proportion of injury-related ED visits during the pandemic, with significant differences in patient demographics and injury patterns. These results can inform burn prevention education.
背景:火灾和烧伤相关损伤是儿童死亡的十大原因之一目的:研究2019冠状病毒病大流行之前和期间儿童烧伤相关损伤模式的差异。方法:这是一项多中心横断面研究的亚分析,该研究对40个儿科急诊科的741,418例损伤相关就诊进行了分析。结果:烧伤相关就诊占所有损伤就诊的2.2% % (N = 12,908)。2020年,烧伤就诊减少了3.7 %,但烧伤就诊相对于其他伤害的比例更高(2.5 % vs. 2.0 %,p )。结论:在大流行期间,烧伤在与伤害相关的急诊就诊中所占比例更高,患者人口统计学和损伤模式存在显著差异。这些结果可为烧伤预防教育提供参考。
{"title":"The impact of COVID-19 on patterns of burns evaluated in pediatric emergency departments","authors":"Stephanie Ruest ,&nbsp;Laurie H. Johnson ,&nbsp;Katherine T. Flynn-O’Brien ,&nbsp;Christina Georgeades ,&nbsp;Holly R. Hanson ,&nbsp;Andrew W. Kiragu ,&nbsp;Michelle T. Ruda ,&nbsp;Mark R. Zonfrillo ,&nbsp;Wendy J. Pomerantz","doi":"10.1016/j.burns.2025.107823","DOIUrl":"10.1016/j.burns.2025.107823","url":null,"abstract":"<div><h3>Background</h3><div>Fire- and burn-related injuries are among the top 10 causes of death for children &lt; 18 years in the United States and are associated with significant morbidity. Data regarding the impact of the COVID-19 pandemic on pediatric burns in emergency department (ED) settings are limited.</div></div><div><h3>Objective</h3><div>To examine differences in pediatric burn-related injury patterns before and during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>This is a subanalysis of a multi-center cross-sectional study of 741,418 injury-related visits to 40 pediatric EDs for children &lt; 18 years. Burn visits were identified by International Classification of Diseases, 10th Revision (ICD-10) codes. Patient demographics and burn-related injury patterns for 3/17/2019–12/31/2019 (control period) vs. 3/15/2020–12/31/2020 (pandemic study period) were compared.</div></div><div><h3>Results</h3><div>Burn-related visits comprised 2.2 % (N = 12,908) of all injury visits. In 2020 there were 3.7 % fewer burn visits, but the proportion of burn visits relative to other injuries was higher (2.5 % vs. 2.0 %, p &lt; 0.001). There were significant differences in burn visits in 2020 by race (p &lt; 0.05) and ethnicity (p = 0.01), with higher proportions of White and non-Hispanic patients. There were significant differences in the geographic distribution of burn visits in 2020 (p &lt; 0.001) and significantly higher proportions of more urgent triage levels (p &lt;0.05) and trauma activations (p &lt; 0.05). Body region affected (p &lt; 0.01), intent (p &lt; 0.001) and mechanism (p &lt; 0.001) also differed significantly. A higher proportion were due to flames/fires and fewer due to hot objects.</div></div><div><h3>Conclusions</h3><div>Burns comprised a higher proportion of injury-related ED visits during the pandemic, with significant differences in patient demographics and injury patterns. These results can inform burn prevention education.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107823"},"PeriodicalIF":2.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chrysin promotes the survival of flaps through the TLR4/NF-κB/NLRP3 signaling pathway Chrysin通过TLR4/NF-κB/NLRP3信号通路促进皮瓣存活
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2025-12-09 DOI: 10.1016/j.burns.2025.107828
Jiapeng Deng , Kai Chen , Xiaoying Jin , Danna Chu , Chaoyang Qi

Purpose

Flap necrosis is a common postoperative complication primarily caused by ischemia-reperfusion injury and impaired angiogenesis. This study investigated the therapeutic effects and mechanisms of chrysin, a natural flavonoid compound extracted from medicinal plants including Oroxylum indicum, Scutellaria baicalensis, and Passiflora spp, on the survival of random skin flaps.

Methods

We employed network pharmacology to analyze chrysin's mechanism of action, predicting its therapeutic targets in ischemic diseases through cross-analysis of its potential targets with the pathophysiological mechanisms of ischemia-reperfusion injury. Molecular docking technology was used to simulate the optimal binding conformation and affinity between chrysin and its target receptors. Additionally, a modified McFarlane flap model was established in 36 Sprague-Dawley rats randomly divided into control, low-dose (10 mg/kg/day), and high-dose (40 mg/kg/day) groups (n = 12 each). Flap survival was evaluated 7 days postoperatively, along with assessments of TLR4/NF-κB/NLRP3 signaling pathway expression, tissue inflammation, oxidative stress levels, and blood perfusion.

Results

Chrysin treatment significantly improved flap survival rate in a dose-dependent manner. The mechanisms involved were 1) inhibiting activation of the TLR4/NF-κB/NLRP3 inflammatory signaling pathway; 2) reducing oxidative stress damage; and 3) promoting angiogenesis through upregulation of VEGF-A expression.

Conclusions

This study demonstrates that the plant-derived flavonoid chrysin improves flap survival through multiple mechanisms, including anti-inflammatory, antioxidant, and pro-angiogenic effects, providing a potential phytotherapeutic strategy for preventing and treating flap necrosis. These findings not only elucidate the pharmacological mechanisms of chrysin but also provide theoretical foundations for developing natural product-based adjuvant therapies in surgery.
目的皮瓣坏死是术后常见的并发症,主要由缺血再灌注损伤和血管新生功能受损引起。本文研究了从药用植物黄芩、黄芩、西番莲中提取的天然黄酮类化合物菊花素(chrysin)对随机皮瓣存活的影响及其机制。方法采用网络药理学方法分析菊花素的作用机制,通过交叉分析其潜在靶点与缺血再灌注损伤的病理生理机制,预测其在缺血性疾病中的治疗靶点。利用分子对接技术模拟了菊花素与其靶受体的最佳结合构象和亲和力。将36只Sprague-Dawley大鼠随机分为对照组、低剂量组(10 mg/kg/day)和高剂量组(40 mg/kg/day),各 = 12只,建立改良麦克法兰皮瓣模型。术后7天评估皮瓣存活,同时评估TLR4/NF-κB/NLRP3信号通路表达、组织炎症、氧化应激水平和血液灌注。结果甘草素治疗可显著提高皮瓣成活率,且呈剂量依赖性。其机制为:1)抑制TLR4/NF-κB/NLRP3炎症信号通路的激活;2)减少氧化应激损伤;3)通过上调VEGF-A表达促进血管生成。结论植物源性黄酮类菊花素可通过抗炎、抗氧化、促血管生成等多种机制改善皮瓣存活,为预防和治疗皮瓣坏死提供了潜在的植物治疗策略。这些发现不仅阐明了菊花素的药理作用机制,也为开发以天然产物为基础的外科辅助治疗提供了理论基础。
{"title":"Chrysin promotes the survival of flaps through the TLR4/NF-κB/NLRP3 signaling pathway","authors":"Jiapeng Deng ,&nbsp;Kai Chen ,&nbsp;Xiaoying Jin ,&nbsp;Danna Chu ,&nbsp;Chaoyang Qi","doi":"10.1016/j.burns.2025.107828","DOIUrl":"10.1016/j.burns.2025.107828","url":null,"abstract":"<div><h3>Purpose</h3><div>Flap necrosis is a common postoperative complication primarily caused by ischemia-reperfusion injury and impaired angiogenesis. This study investigated the therapeutic effects and mechanisms of chrysin, a natural flavonoid compound extracted from medicinal plants including Oroxylum indicum, Scutellaria baicalensis, and Passiflora spp, on the survival of random skin flaps.</div></div><div><h3>Methods</h3><div>We employed network pharmacology to analyze chrysin's mechanism of action, predicting its therapeutic targets in ischemic diseases through cross-analysis of its potential targets with the pathophysiological mechanisms of ischemia-reperfusion injury. Molecular docking technology was used to simulate the optimal binding conformation and affinity between chrysin and its target receptors. Additionally, a modified McFarlane flap model was established in 36 Sprague-Dawley rats randomly divided into control, low-dose (10 mg/kg/day), and high-dose (40 mg/kg/day) groups (n = 12 each). Flap survival was evaluated 7 days postoperatively, along with assessments of TLR4/NF-κB/NLRP3 signaling pathway expression, tissue inflammation, oxidative stress levels, and blood perfusion.</div></div><div><h3>Results</h3><div>Chrysin treatment significantly improved flap survival rate in a dose-dependent manner. The mechanisms involved were 1) inhibiting activation of the TLR4/NF-κB/NLRP3 inflammatory signaling pathway; 2) reducing oxidative stress damage; and 3) promoting angiogenesis through upregulation of VEGF-A expression.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that the plant-derived flavonoid chrysin improves flap survival through multiple mechanisms, including anti-inflammatory, antioxidant, and pro-angiogenic effects, providing a potential phytotherapeutic strategy for preventing and treating flap necrosis. These findings not only elucidate the pharmacological mechanisms of chrysin but also provide theoretical foundations for developing natural product-based adjuvant therapies in surgery.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107828"},"PeriodicalIF":2.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Burns
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