Burns最新文献

{"title":"Increased systemic heat-shock protein 27 and 70 following severe burn injury","authors":"Bastian Garmroudi ,&nbsp;Thomas Haider ,&nbsp;Carmen Haider ,&nbsp;Philipp Hacker ,&nbsp;Gregor Werba ,&nbsp;Hendrik Jan Ankersmit ,&nbsp;Stefan Hacker","doi":"10.1016/j.burns.2025.107846","DOIUrl":"10.1016/j.burns.2025.107846","url":null,"abstract":"<div><h3>Background</h3><div>Severe burn injuries trigger a complex systemic response, including dysregulated inflammation and immunosuppression. Heat shock proteins (HSPs) regulate cellular stress responses and have immunomodulatory functions when released into the extracellular compartment. Our aim was to investigate the release of systemic HSP27 and 70 in patients suffering from severe burn injury.</div></div><div><h3>Methods</h3><div>We analyzed serum HSP27 and HSP70 concentrations in 32 burn patients admitted to our burn intensive care unit with a total body surface area (TBSA) affected of &gt; 10 % in comparison to eight healthy control probands. HSP27 and 70 concentrations were determined serially for four weeks using enzyme-linked immunosorbent assays (ELISA).</div></div><div><h3>Results</h3><div>The mean TBSA was 32.5 % ± 19.6 %, and in-hospital mortality occurred in six patients (18.8 %). HSP27 and HSP70 concentrations were significantly elevated in burn patients compared to controls, with peak concentrations on the day of admission (HSP27: 590 ± 335 vs. 83 ± 42 pg/mL, p &lt; 0.001; HSP70: 1961 ± 2214 vs. 189 ± 130 pg/mL, p &lt; 0.001). HSP70 concentrations were significantly higher in non-survivors (1143 vs. 946 pg/mL, p &lt; 0.05) and were significantly higher in patients with more than 29 % TBSA compared to patients with lower TBSA (p &lt; 0.01). Receiver operating characteristic curve analysis identified HSP70 measured on the day of admission as a significant predictor of patient mortality.</div></div><div><h3>Conclusion</h3><div>Severe thermal trauma results in elevated HSP27 and HSP70 concentrations. Increased HSP70 levels are associated with higher in-hospital mortality in burn patients, suggesting potential use as a prognostic biomarker.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107846"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"optiTHERMM: A trainee-led international collaborative survey on perioperative patient body temperature monitoring and management for major burn injuries","authors":"Guy H.M. Stanley ,&nbsp;Majid Al-Khalil ,&nbsp;Cody C. Frear ,&nbsp;Glenn Boardman ,&nbsp;Lorna A. Burrows ,&nbsp;Skylar Paulich ,&nbsp;Jennifer C. Field ,&nbsp;Jonathon M. Pleat ,&nbsp;The optiTHERMM collaborators","doi":"10.1016/j.burns.2025.107817","DOIUrl":"10.1016/j.burns.2025.107817","url":null,"abstract":"<div><h3>Introduction</h3><div>Major burn injuries are often accompanied by disturbances in thermoregulation, with perioperative hypo- and hyperthermia presenting significant challenges for clinicians. Despite its implications for patient outcomes, research into perioperative thermoregulation and its influence on surgical decision-making remains limited.</div></div><div><h3>Methods</h3><div>Between February 2022 and June 2023, a 26-question survey was distributed to clinicians in the UK, Australia, and New Zealand to assess body temperature management practices for major burn patients. Respondents included burn surgeons, anaesthetists, and intensive care specialists, categorised by burn service complexity and patient demographics.</div></div><div><h3>Results</h3><div>A total of 148 responses were collected, with 96 from the UK (22 sites) and 52 from Australia and New Zealand (22 sites), achieving a response rate of 70 % among designated burn services (39/56). Most clinicians reported an absence (38 %) or lack of awareness (22 %) regarding local thermoregulation protocols. Hypothermia was more likely than hyperthermia to cause surgery delays, with 35° C cited as the most common threshold. No significant differences were found in temperature thresholds based on service complexity (p = 0.324), patient demographics (p = 0.67), or clinician roles (p = 0.238). Respondents from high-complexity hospitals reported significantly lower minimum and higher maximum preferred body temperature thresholds <em>during</em> surgery (p = 0.008 and p = 0.02, respectively). However, these thresholds did not differ significantly based on patient population (p = 0.259; p = 0.897) or clinician role (p = 0.409; p = 0.283). Methods used to monitor and manage body temperature were broadly consistent with those cited in other studies.</div></div><div><h3>Conclusions</h3><div>This international study represents the largest investigation of thermoregulation practices in major burns to date. While a consensus on optimal monitoring and modulation methods exists, there is considerable variability in practices and temperature preferences, highlighting the need for evidence-based guidelines to ensure consistent and optimal care.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107817"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of hemoglobin levels and mortality in burn patients","authors":"Qinghua Wu ,&nbsp;Jingwei Zhang ,&nbsp;Caoyi Liu ,&nbsp;Zhiyong Huang","doi":"10.1016/j.burns.2025.107840","DOIUrl":"10.1016/j.burns.2025.107840","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the correlation between hemoglobin (Hb) levels and 1-year mortality in burn patients in intensive care units.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study, extracting relevant data from the American Intensive Care Unit (ICU) Medical Information Database IV (MIMIC-IV) for burn patients. This data included complete blood counts, biochemistry and coagulation parameters (both maximum and minimum values during ICU hospitalization), Simplified Acute Physiology Score II (SAPSII), Acute Physiology ScoreIII (APSIII), Oxford Acute　Severity of Illness Score (Oasis), Sequential Organ Failure Assessment (SOFA), comorbidities, and outcome. A restricted cubic spline model was utilized to illustrate the relationship between Hb levels and 1-year mortality risk. Patients were stratified into three groups based on gender and the relationship curve (Female: Hb&lt;10.0 g/dL, 10.0 g/dL≤Hb&lt;11.5 g/dL, Hb≥11.5 g/dL; Male: Hb&lt;11.0 g/dL, 11.0 g/dL≤Hb&lt;12.5 g/dL, Hb≥12.5 g/dL). Logistic regression models were employed to assess one-year mortality risk in each group, while sensitivity analysis was conducted via subgroup analysis and propensity score matching (PSM) analysis.</div></div><div><h3>Results</h3><div>A total of 278 burn patients were included in the study, revealing a one-year mortality rate of 12.2 %. Classifying the patients according to their Hb levels in 3 groups, the numerical mortality rates was different (Q1:22.1 %, Q2:8.9 %, Q3:7.0 %). Whether treating Hb as a continuous or categorical variable, both univariate and multivariate logistic regression analyses indicated a gradual decrease in mortality as Hb levels increased. In models adjusted for all confounding factors, the mortality risk for the second and third Hb groups was significantly lower compared to the first group (OR=0.29, 95 % CI=0.10–0.79, p = 0.016; vs. OR=0.36, 95 % CI=0.14–0.93, p = 0.035). Subgroup analysis displayed consistent correlations between reduced Hb levels and increased mortality across various ages, genders, and comorbidities, including chronic pulmonary disease, cerebrovascular disease, liver disease, kidney diseases, and diabetes. After stratifying patients into two groups (Female: Hb&lt;11.0 g/dL and Hb≥11.0 g/dL; Male: Hb&lt;12.0 g/dL and Hb≥12.0 g/dL) and adjusting for potential confounders using Propensity Score Matching (PSM) analysis, as well as applying propensity score adjustment and weighted pairwise analysis (PA), the results remained stable (OR=0.34, CI=0.14–0.83, p = 0.017).</div></div><div><h3>Conclusion</h3><div>Lower Hb levels in burn patients during ICU hospitalization are associated with higher one-year mortality.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107840"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational impact of a cost-efficient burns excision and skin grafting porcine simulation model","authors":"Ameen Mahmood ,&nbsp;Ayushi Gianchandani ,&nbsp;Cheuk Ying Kyleen Kiew ,&nbsp;Anuska Shah ,&nbsp;Hasan Zaidi ,&nbsp;Abith Kamath ,&nbsp;Rananjay Singh ,&nbsp;Nikita Kartikapallil ,&nbsp;Marya Abuarqoub ,&nbsp;Daniel Markeson","doi":"10.1016/j.burns.2025.107836","DOIUrl":"10.1016/j.burns.2025.107836","url":null,"abstract":"<div><h3>Introduction</h3><div>Burns education is underrepresented in UK undergraduate and early postgraduate medical training, despite being a core emergency presentation. This limits exposure to essential principles and skills. Porcine skin is anatomically similar to human tissue and cost-efficient, offering a valuable tool. This study evaluates the educational impact of a low-cost burns excision and skin-grafting porcine-based simulation model.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted through a workshop comprising a lecture on burns followed by hands-on practice using porcine models. Participants completed pre- and post-workshop surveys, including multiple choice questions and evaluated self-rated confidence and perceptions using five-point Likert scales. Technical skills were assessed using supervisor-rated Objective Structured Assessment of Technical Skills (OSATS). Statistical analysis utilised Wilcoxon signed-rank and McNemar’s Tests.</div></div><div><h3>Results</h3><div>Thirty participants (28 medical students and two resident doctors) with no prior experience in burns management or grafting partook in the workshop. Theoretical knowledge significantly improved from 1.8 ± 0.7 to 3.9 ± 0.9 (p &lt; 0.01), and surgical skills increased from 1.6 ± 0.7 to 3.6 ± 1.0 (p &lt; 0.01). OSATS scoring showed significant improvements across all domains (p &lt; 0.01). Knowledge-based assessments improved significantly in graft layers, total body surface area (TBSA), and viability assessment (p &lt; 0.01). Participants rated the workshop's effectiveness score at 4.6 ± 0.7 and recommendation likelihood at 4.3 ± 0.5.</div></div><div><h3>Conclusions</h3><div>The model significantly improves knowledge, confidence, and technical skills in burns management and grafting.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107836"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of socioeconomic deprivation on the adequacy of burn first aid: a retrospective cohort study","authors":"Man Hin Kong ,&nbsp;Alexander J. Baldwin ,&nbsp;Ryan Kerstein","doi":"10.1016/j.burns.2026.107864","DOIUrl":"10.1016/j.burns.2026.107864","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to examine the relationship between socioeconomic status, measured by the Index of Multiple Deprivation (IMD), and the adequacy of first aid provided for burn injuries.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted including all patients (paediatric and adult) treated for thermal burns at a regional burn unit between 1 May and 31 July 2024. Socioeconomic status was assessed using IMD deciles. First aid was categorised as “adequate” (cooling with water for ≥20 min) or “inadequate,” with inadequate first aid further classified as “damaging” (e.g., ice, toothpaste, raw egg) or “not damaging.” Logistic regression analyses adjusted for age, sex, burn aetiology and size of burn.</div></div><div><h3>Results</h3><div>269 patients were included (median age 28.3 years; 66.9 % adults; 50.9 % male). Scalds were the most common aetiology (59.5 %), and most burns were superficial partial thickness (82.5 %). The median IMD decile was 7 (IQR 5–9). Increasing socioeconomic deprivation (lower IMD decile) was significantly associated with inadequate first aid (OR 0.898 [per unit decrease in IMD decile] 95 % CI 0.807–0.998, p = 0.046). Greater deprivation was also associated with increased odds of harmful first aid practices, compared with adequate first aid (RRR 0.836, 95 % CI 0.737–0.948, p = 0.005).</div></div><div><h3>Conclusion</h3><div>Socioeconomic deprivation is inversely associated with adequate burn first aid and positively associated with harmful practices. Targeted public health interventions are needed to address this disparity.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107864"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting skin keratinocyte and fibroblast extraction yields for the production of living skin substitutes to treat severely burned patients","authors":"Ludivine Dubourget ,&nbsp;Danielle Larouche ,&nbsp;Sergio Cortez Ghio ,&nbsp;Véronique J. Moulin ,&nbsp;Chanel Beaudoin-Cloutier ,&nbsp;Lucie Germain","doi":"10.1016/j.burns.2025.107805","DOIUrl":"10.1016/j.burns.2025.107805","url":null,"abstract":"<div><h3>Backgrounds</h3><div>As autografting is limited for severely burned patients due to a lack of healthy donor sites, tissue-engineered autologous skin substitutes have emerged as a promising alternative. Yet, challenges persist, particularly regarding production time. Since cell culture is influenced by multiple factors, identifying these factors is crucial for improving culture yields. This retrospective study aimed to identify factors affecting skin cell extraction yields.</div></div><div><h3>Methods</h3><div>Culture data (method used, etc.) and clinical data (medical history, etc.) from all available patient records over a 35-year-period were collected. 18 variables were assessed using XGBoost as a variable selection tool, before fitting mixed-effects multivariate linear modeling.</div></div><div><h3>Results</h3><div>As expected, age inversely correlated with keratinocyte and fibroblast extraction yields, decreasing by 0.048 × 10⁶ cells/cm² per year (CI_95 % = [-0.065;-0.031]) and 0.035 × 10⁶ cells/cm² per year (CI_95 % = [-0.050;-0.019]), respectively. Keratinocyte yield also rose by 0.936 × 10⁶ cells/cm² (CI_95 % = [0.175;1.697]) when hairs could be grasped during the epidermis-dermis separation. Conversely, fibroblast yield increased by 0.042 × 10⁶ cells/cm² per day post-burn (CI_95 % = [0.007;0.076]) and by 0.019 × 10⁶ cells/cm² per percentage of TBSA burned (CI_95 % = [0.002;0.036]).</div></div><div><h3>Conclusions</h3><div>This findings provide valuable insights into factors influencing skin cell extraction yields, which may help optimize skin biopsy parameters, ultimately improving production efficiency.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107805"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fire safety measures in commercial complex residents: Application of protection motivation theory","authors":"Mohammadreza Shokouhi ,&nbsp;Fahimeh Ramezani ,&nbsp;Ali Fardi ,&nbsp;Maryam Afshari ,&nbsp;Salman Khazaei ,&nbsp;Forouzan Rezapur-Shahkolai","doi":"10.1016/j.burns.2025.107830","DOIUrl":"10.1016/j.burns.2025.107830","url":null,"abstract":"<div><h3>Background</h3><div>Fires in commercial buildings are of particular concern given their essential role in economic and social development. While fire safety research has often emphasized structural aspects of buildings, comparatively less attention has been paid to residents’ behavioral responses during fire incidents. Moreover, a considerable portion of the existing literature on fire safety lacks a robust theoretical foundation. To address this gap, the present study applies the Protection Motivation Theory (PMT) to examine factors influencing fire prevention behaviors among residents of commercial complexes.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study was conducted between September and December 2024 among 910 residents of commercial complexes in Hamadan. Participants were selected using a stratified sampling method based on complex size, followed by simple random sampling for individual inclusion. Data were collected through structured interviews with a questionnaire consisting of two sections: demographic and background information, and constructs derived from the PMT.</div></div><div><h3>Results</h3><div>The mean age of participants was 41.6 years, with an average of 7.6 working hours per day. Most participants were male (81.2 %) and had a middle school level of education (52.2 %). Nearly 12.2 % reported previous experience with a fire incident. In addition, higher scores of perceived susceptibility, perceived severity, fear, self-efficacy, response efficacy, perceived rewards, and protection motivation were associated with increased engagement in preventive measures. Daily working hours were also found to have a statistically significant correlation with the adoption of protective behaviors against fire in commercial buildings.</div></div><div><h3>Conclusion</h3><div>The findings of this study highlight the critical importance of fire prevention among individuals working in commercial complexes, given their unique occupational conditions. To ensure effective planning and implementation of preventive and intervention programs, it is essential to comprehensively identify the determinants of protective behaviors.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107830"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The rise of the robot authors","authors":"Leopoldo C. Cancio","doi":"10.1016/j.burns.2026.107862","DOIUrl":"10.1016/j.burns.2026.107862","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107862"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 receptor agonists after recent burn injury are associated with lower rates of infection, mortality, and opioid prescriptions","authors":"Matthew Q. Dao ,&nbsp;Anika Y. Kim ,&nbsp;Sarah Wang ,&nbsp;Paul Won ,&nbsp;Matteo Laspro ,&nbsp;T. Justin Gillenwater ,&nbsp;Haig A. Yenikomshian ,&nbsp;Maxwell B. Johnson","doi":"10.1016/j.burns.2025.107848","DOIUrl":"10.1016/j.burns.2025.107848","url":null,"abstract":"<div><h3>Introduction</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for glycemic control and weight loss. In addition, these medications have been associated with anti-inflammatory activity, modulation of wound healing, and reduction of substance use disorders. Therefore, GLP-1 RAs may have therapeutic benefits in burn care. This study investigates whether early administration of GLP-1 RAs after burn injury is associated with clinical outcomes.</div></div><div><h3>Methods</h3><div>The Global Collaborative Network was queried in TriNetX, a database of electronic health records. The treatment group included burn patients who received GLP-1 RAs within 30 days of injury. This group was propensity matched with patients who did not receive GLP-1 RAs. Patients were matched by demographics, comorbidities, and burn characteristics. Outcomes at 90 days and 1 year following burn injury were compared, with statistical significance defined as p &lt; 0.05.</div></div><div><h3>Results</h3><div>Following matching, each group was composed of 3231 patients. At 90 days post-burn, the GLP-1 RA group had significantly lower rates of soft tissue infection, opioid prescriptions, readmission, and mortality (all p &lt; 0.05). At 1 year post-burn, lower rates of opioid prescriptions, readmission, and mortality persisted (all p &lt; 0.05), while soft tissue infection rates remained numerically lower but did not reach statistical significance. No significant differences were observed for wound disruption, hypertrophic scar formation, or contracture formation at either time point.</div></div><div><h3>Conclusions</h3><div>GLP-1 RAs after recent burn injury were associated with lower risk of infection, opioid prescriptions, readmission, and mortality. Their utility in burn care is promising, and additional research is needed.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107848"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation","authors":"Jialong Yang ,&nbsp;An Wang ,&nbsp;Zhengyang Qi ,&nbsp;Panshen Xu ,&nbsp;Hebin Pan ,&nbsp;Weilong Song ,&nbsp;Kaitao Wang ,&nbsp;Dingsheng Lin","doi":"10.1016/j.burns.2026.107872","DOIUrl":"10.1016/j.burns.2026.107872","url":null,"abstract":"<div><h3>Background</h3><div>Skin flap necrosis due to ischemia-reperfusion (I/R) injury remains a major obstacle in plastic and reconstructive surgery. Galangin (Gal) is a natural flavonoid with potent antioxidant and anti-inflammatory properties; its effect on ischemic flap necrosis remains unclear.</div></div><div><h3>Methods</h3><div>Network pharmacology and molecular docking were used to predict the interaction between Gal and SIRT1. In vitro, human umbilical vein endothelial cells were subjected to oxygen-glucose deprivation/reperfusion to simulate I/R injury, and subsequent assessments of cell viability and ferroptosis were performed. The SIRT1 inhibitor EX527 and the ferroptosis inhibitor Ferrostatin-1 were used to verify the ferroptosis-related mechanisms. In vivo, a modified McFarlane skin flap model was created in rats. Gal-treated groups were compared to a control group to evaluate flap survival, blood perfusion, histological changes, and the expression of key proteins in the SIRT1/FOXO1 pathway.</div></div><div><h3>Results</h3><div>In vitro, Gal protected HUVECs by suppressing ferroptosis. Mechanistically, Gal upregulated SIRT1, promoted FOXO1 deacetylation, increased expression of downstream proteins and inhibited lipid peroxidation. These protective effects were diminished by SIRT1 inhibition. In vivo, Gal treatment significantly increased flap survival area and blood perfusion in a dose-dependent manner. It also suppressed neutrophil infiltration, reduced MDA levels, increased SOD activity, and inhibited pro-inflammatory cytokines and activate anti-ferroptosis proteins.</div></div><div><h3>Conclusions</h3><div>Gal enhances skin flap survival by suppressing ferroptosis, oxidative stress, and inflammation via activation of the SIRT1/FOXO1 pathway.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107872"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}