Burns最新文献

{"title":"Corrigendum to “Examination of the effects of kefir on healing factors in a mice burn model infected with E. coli, S. aureus and P. aeruginosa using qRT-PCR” [Burns 49 (2023) 425–431]","authors":"Songul Cetik Yildiz , Cemil Demir , Adnan Ayhanci","doi":"10.1016/j.burns.2024.107370","DOIUrl":"10.1016/j.burns.2024.107370","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107370"},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of nitrile gloves on temperature perception during hot water immersion","authors":"David Cussons ,&nbsp;Aude Perusseau-Lambert ,&nbsp;Quentin Frew ,&nbsp;David Barnes ,&nbsp;Simon Myers ,&nbsp;Peter Dziewulski","doi":"10.1016/j.burns.2025.107392","DOIUrl":"10.1016/j.burns.2025.107392","url":null,"abstract":"<div><h3>Introduction</h3><div>Scalds account for 40 % of burn injuries in developed countries, with a subset occurring during caregiving activities, particularly when gloves are worn. Gloves, a standard precaution against infection and body fluid exposure, may impair sensory feedback critical for detecting temperature changes, potentially increasing the risk of burns during personal care tasks.</div></div><div><h3>Methods</h3><div>This study investigated the impact of glove use on heat perception. Twelve healthy participants (6 male, 6 female) immersed their index fingers in water baths set at 40°C, 45°C, 50°C, 55°C, and 60°C. Heat perception thresholds were assessed under three conditions: no gloves, single gloves, and double gloves. Participants withdrew their fingers upon feeling discomfort, and the withdrawal temperatures were recorded.</div></div><div><h3>Results</h3><div>Our trial showed that gloves significantly delayed heat discomfort detection, with the longest delays observed at 50°C and 55°C when double gloves were worn. Wearing a single glove raised the discomfort threshold by approximately 5°C, while double gloves increased it by 10°C. This logarithmic relationship between temperature and perception delay indicates a substantial sensory alteration, especially at higher temperatures.</div></div><div><h3>Conclusion</h3><div>The findings underscore the heightened risk of scald injuries in vulnerable individuals due to delayed heat detection caused by gloves. Awareness of altered temperature thresholds during glove use is essential to prevent burns during caregiving tasks, particularly in activities requiring precise temperature assessment, such as bathing or showering. Enhanced education and preventive measures are crucial for ensuring safety in these contexts.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107392"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis to explore the molecular mechanisms related to keloid","authors":"Hailin Xu ,&nbsp;Keai Li ,&nbsp;Xiaofeng Liang ,&nbsp;Zhiyong Wang ,&nbsp;Bin Yang","doi":"10.1016/j.burns.2025.107396","DOIUrl":"10.1016/j.burns.2025.107396","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Keloid is a benign skin tumor that result from abnormal wound healing and excessive collagen deposition. The pathogenesis is believed to be linked to genetic predisposition and immune imbalance, although the precise mechanisms remain poorly understood. Current therapeutic approaches may not consistently yield satisfactory outcomes and are often accompanied by potential side effects and risks. The high recurrence rate and refractory nature of keloid nodules present significant challenges and uncertainties in their management. Given the lack of effective treatment strategies, it is essential to identify key molecular pathways and potential therapeutic targets for keloid.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aimed to identify the potential pathogenic mechanisms, hub genes, and immune cell involvement in keloid formation, with the goal of providing novel insights for targeted therapies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We utilized a combination of bulk RNA sequencing to analyze gene expression profiles in keloid tissues. Differentially expressed genes (DEGs) were identified and subjected to pathway enrichment analysis to reveal key biological processes involved in keloid pathogenesis. Mendelian randomization was performed to investigate the causal relationship between genetic factors and keloid formation, identifying potential hub genes. Immune infiltration analysis was conducted to determine the role of specific immune cells in keloid development. Subsequently, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) were performed to investigate the functional pathways associated with the hub genes. Network analysis was employed to identify transcription factors, miRNAs, and potential drugs in the Connectivity Map associated with the hub genes. Single-cell RNA sequencing was also used to identify cell-specific expression patterns of these genes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Pathway enrichment analysis highlighted the association of keloid pathogenesis with cell proliferation and division, providing insights into the molecular processes involved. Mendelian randomization revealed that DUSP1 acts as an inhibitor of keloid formation, while HOXA5 promotes keloid pathogenesis. Immune infiltration analysis suggested that mast cells and macrophages play critical roles in the disease's progression. Based on hub gene analysis, the IL17 signaling pathway emerged as a key pathway implicated in keloid development. Further drug prediction models identified 9-methyl-5H-6-thia-4, 5-diaza-chrysene-6, 6-dioxide, zebularine, temozolomide and valproic acid targeting these hub genes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;DUSP1 and HOXA5 are hub genes in keloid pathogenesis, with DUSP1 acting as an inhibitor and HOXA5 as a promoter of disease progression. Targeting the regulatory networks associated with these genes could provide novel therapeutic strategies. Mast cells and macrophages are identif","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107396"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early coagulation disorder and the predictive value of D-dimer for deep vein thrombosis in major burn patients","authors":"Ning Li ,&nbsp;Jianglin Tan ,&nbsp;Xue Feng ,&nbsp;Maojun Li ,&nbsp;Li Qin ,&nbsp;Junyi Zhou","doi":"10.1016/j.burns.2025.107398","DOIUrl":"10.1016/j.burns.2025.107398","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate coagulation disorders and thrombotic complications in the early stage after burn, and to evaluate the predictive reliability of D-dimer for deep vein thrombosis (DVT) diagnosis in major burn patients.</div></div><div><h3>Methods</h3><div>This retrospective study was performed in the Department of Burns, Southwest Hospital, and included 288 adult major burn patients (≥40 % TBSA) without prophylactic anticoagulant therapy. All patients received routine screening assays of coagulation indicators and Doppler ultrasound scan (DUS) during the 28 days post-burn regardless of the clinical symptoms of DVT.</div></div><div><h3>Results</h3><div>Coagulation abnormalities were commonly observed during the 28 days post-burn. There were 24 patients (8.33 %) diagnosed with DVT based on DUS on a median of 23 days after burn. Older age (OR=1.47) and increased insertions of central venous catheter (OR=1.67) were identified as independent risk factors for DVT. Serum D-dimer levels were elevated in 97.6 % (281/288) of patients in the first week post-burn. Patients identified with DVT had significantly higher serum D-dimer levels on the 3rd and 7th days post-burn. The D-dimer level on the 7th post-burn day showed a moderate predictive value for DVT by ROC analysis (AUC=0.711). The optimal threshold was 2.25 mg/L, with a sensitivity of 0.818 and a specificity of 0.566 at this threshold.</div></div><div><h3>Conclusion</h3><div>Early coagulation disorder can occur and last for over 28 days after major burn injury. The serum D-dimer level on the 7th post-burn day may be used as a risk factor to identify the individuals with high-risk of DVT among major burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107398"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of multidisciplinary cooperation in treating 15 extensively burned casualties：The Zhejiang LNG tanker explosion on 13 June 2020","authors":"Hu hang ,&nbsp;Wang yiran ,&nbsp;Jiang Hongfei ,&nbsp;Huang Man ,&nbsp;Han chunmao","doi":"10.1016/j.burns.2024.107361","DOIUrl":"10.1016/j.burns.2024.107361","url":null,"abstract":"<div><h3>Background</h3><div>On June 13, 2020, an explosion involving a liquefied natural gas (LNG) tanker truck occurred in eastern China. Fifteen patients with extremely severe burns (referred to as “June 13” patients) were treated in the burn-intensive care unit (ICU) joint ward within the general ICU.</div></div><div><h3>Methods</h3><div>A multidisciplinary treatment team comprising 129 doctors, 126 nurses, and 165 auxiliary staff members was assembled. Additionally, 15 burn and ICU experts from various regions of China joined us. After concluding the treatment, patient data were collected and analyzed. The differences in clinical data between the deceased and surviving patients were retrospectively compared. Subsequently, the clinical data of 177 non-“June 13” patients with total burned body surface area (TBSA) &gt; 50 % treated in the burn department from 2016 to 2023 were collected to compare the efficacy of our multidisciplinary collaborative treatment model.</div></div><div><h3>Results</h3><div>The average TBSA of 15 “June 13” patients was 85.07 ± 15.85 % (range 50–98 %). Among them, 11 patients had a TBSA greater than 90 %, with 6 exceeding 95 %. Seven patients succumbed to their injuries, while 8 patients survived. The incidence of severe complications, such as multiple organ failure (MOF) and fungal infections, was higher in the deceased group than in the survival group. The surviving patients exhibited larger burn wound areas repaired by skin grafting on the 30th and 60th days, with significantly less residual wound area than the deceased group. In comparison with the non-“June 13” patients, the “June 13” patients were notably older and had larger TBSA, as well as larger areas of third-degree TBSA and higher mean revised Baux scores. After 1:2 matching for revised Baux score, the “June 13” group underwent a significantly higher number of operations (p-value =0.007). The “June 13” group showed a lower mortality rate, although not statistically significant (20 % vs 55 %, p = 0.119; log-rank p = 0.059 for Kaplan-Meier curves).</div></div><div><h3>Conclusion</h3><div>Multidisciplinary collaboration, guided by a comprehensive treatment plan, may improve the management of patients with extensive burns. Timely and effective surgical management is crucial for reducing mortality and improving patient prognosis.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107361"},"PeriodicalIF":3.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Livedo e calore following repeated warming bottle applications in an Alpine mountain setting","authors":"Christina Ravens,&nbsp;Marie-Charlotte Brüggen,&nbsp;Matthias Möhrenschlager","doi":"10.1016/j.burns.2025.107390","DOIUrl":"10.1016/j.burns.2025.107390","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107390"},"PeriodicalIF":3.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of black mulberry, chokeberry, and elderberry extracts on the healing of burn wounds","authors":"Rukiye Zengi̇n ,&nbsp;Selim Erdoğan ,&nbsp;Onural Özhan ,&nbsp;Elif Taşlidere Karaca ,&nbsp;Semih Özçinar ,&nbsp;Yakup Yilmazteki̇n ,&nbsp;Fatma Hilal Yağin ,&nbsp;Yılmaz Uğur ,&nbsp;Cemal Firat ,&nbsp;Hakan Parlakpinar ,&nbsp;Ayşe Burçin Uyumlu","doi":"10.1016/j.burns.2025.107391","DOIUrl":"10.1016/j.burns.2025.107391","url":null,"abstract":"<div><h3>Background</h3><div>In the burn affected area of the skin, the progression or deepening of wounds is related to oxidative stress. Especially in the highly susceptible stasis zone, tissues survive to the extent that they can cope with oxidative stress.</div></div><div><h3>Objective</h3><div>This study investigated the potential of extracts (E) derived from the fruits (F) and leaves (L) of elderberry (E), chokeberry (C), and black mulberry (M), which are rich in antioxidant properties, to enhance the recovery of the stasis zone in burn wounds.</div></div><div><h3>Methods</h3><div>The study employed a sample size of 56 healthy rats. The comb burn model was used. The rats were administered the extracts via gastric gavage for a period of 21 days. Histological examination and biochemical analyses were conducted on biopsies taken from the stasis zone on the 3rd, 7th, and 21st days of the study. Photography was performed for macroscopic evaluations. The histological assays included the evaluation of inflammatory cell infiltration, reepithelialization, and collagenization, as well as immunohistochemical analysis of vascular endothelial growth factor (VEGF). Bioassays pertaining to the enzymatic activities of catalase, superoxide dismutase, glutathione peroxidase, and malondialdehyde (MDA) levels were performed.</div></div><div><h3>Results</h3><div>In macroscopic evaluation, a significant difference was found between the groups in terms of stasis area (F=3.58, p₂&lt; 0.001). Post-hoc analyses showed that there was a significant difference between CFE-ELE, EFE-Burn, ELE-Burn and MLE-Burn groups in terms of stasis zones (p &lt; 0.05). However, the difference between the groups according to time was not significant (F=1.36, p = 0.16). At the end of the 21-day experiment, inflammatory cell infiltration was higher in the burn group compared to the other groups, but similar to the CFE group. Re-epithelialization was similar in the burn group compared to the fruit extract groups and significantly lower compared to the leaf extract groups. Furthermore, a significant increase in collagenization and VEGF immunoreactivity was observed in all treatment groups compared to the burn group (p &lt; 0.05). However, no significant difference was detected between the treatment groups. The treatment groups presented a notable reduction in MDA levels in comparison to the burn group (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>This study demonstrated the efficacy of fruit and leaf extracts in burn healing. Histological examination revealed that leaf extracts exhibited superior healing effects compared to fruit extracts. These results suggest that bioactive components in fruits and leaves may have different biological effects.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107391"},"PeriodicalIF":3.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and cross-country inequalities in global burns burden among children and adolescents: A population-based study from 1990 to 2021","authors":"Kan Wang ,&nbsp;Chen Jiang ,&nbsp;Qiqi Wu ,&nbsp;Zhanfei Li","doi":"10.1016/j.burns.2025.107377","DOIUrl":"10.1016/j.burns.2025.107377","url":null,"abstract":"<div><h3>Background</h3><div>Burns among children and adolescents represent a significant global health burden, leading to substantial morbidity and disability. This study aimed to analyze the trends in burn incidence, prevalence, and years lived with disability (YLDs) from 1990 to 2021, and to project future trends to 2035, highlighting global and regional disparities.</div></div><div><h3>Methods</h3><div>We utilized data from the Global Burden of Disease (GBD) database covering 204 countries and territories. Burn data were extracted from multiple sources including hospital records, health surveys, and national health databases. Trend analysis was projected using the Bayesian age-period-cohort (BAPC) model. Health inequality was assessed using the slope index of inequality (SII) and the concentration index (CI).</div></div><div><h3>Results</h3><div>In 2021, the global incidence of burns among children and adolescents was 8,484,254 cases, with an age-standardized incidence rate (ASIR) of 1315.94 per 100,000 population, showing an annual reduction of 1.33 % from 1990. The prevalence and YLDs also showed significant annual declines. Males had higher incidence rates than females. Younger children (0–4 years) experienced the highest incidence rates, while adolescents (15–19 years) had the highest prevalence. Regional disparities were evident, with Central Asia and Central Europe having the highest ASIRs. The SII and CI indicated persistent socio-economic health disparities, with lower socio-demographic index (SDI) countries bearing a disproportionate burden. Predictive analysis suggests a continued decline in burn incidence, prevalence, and YLDs through 2035. Additionally, burns among adolescents and young adults result in significant loss of labor force, exacerbating socio-economic challenges in affected regions.</div></div><div><h3>Conclusion</h3><div>The global burden of burns in children and adolescents has decreased significantly, yet substantial disparities persist across different regions and socio-economic strata. Continued efforts in improving burn prevention, treatment, and rehabilitation are essential to further reduce the burden and address health inequalities.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107377"},"PeriodicalIF":3.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absorbable Meek skin graft material transplantation: A preliminary experimental study","authors":"Feng Li ,&nbsp;Jin-yu Zhang ,&nbsp;Yan-lin Guo ,&nbsp;Wei Zhang","doi":"10.1016/j.burns.2025.107387","DOIUrl":"10.1016/j.burns.2025.107387","url":null,"abstract":"<div><h3>Background</h3><div>Wound closure is the core issue in treating patients with extensive burns. Allogeneic grafts can serve as a suitable temporary substitute in third-degree burns, and the Meek technique has provided encouraging outcomes in recent decades. However, whether allografts and the Meek technique could be used simultaneously so as to leverage the strengths of both has not been extensively examined. Therefore, we aimed to develop absorbable Meek skin graft materials to achieve transplantation of allografts and autografts in a single step.</div></div><div><h3>Methods</h3><div>Regenerated cellulose was used to make absorbable MEEK materials. The allogeneic skin donor and graft recipient were both pigs. Full-thickness skin excision wounds were made on both sides of the back as experimental and control groups respectively. The experimental group was transplanted with absorbable Meek material, which was then covered with an overlay of allografts. The control group was transplanted with Meek micrografting. Gross appearance and histology of the grafts were compared, as well as the level of four inflammatory factors in tissue samples.</div></div><div><h3>Results</h3><div>In the early postoperative period, there was little exudation of the wound and the allografts were viable. In the next few days, a thin eschar had formed on the surface of the allografts and the allografts transformed into a crust, and then separated from the wound. The wound healed by day 28. In the control group, the wound exudate was significantly more than that in the experimental group and most wounds had basically healed by day 21. Histology of allografts appeared intact by day 7, but the abundance of epidermal cells decreased, and then almost disappeared. Epithelialization was almost complete by day 28 in the experimental group，which was slightly later than in the control group. There were no significant differences in the level of inflammatory factors.</div></div><div><h3>Conclusions</h3><div>The use of absorbable Meek skin graft materials allowed for the transplantation of autologous and allogeneic skin grafts in one step and can be expected to have a positive impact on the clinical treatment of extensive burn injuries. However, further improvements are needed to accelerate wound repair.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107387"},"PeriodicalIF":3.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causal relationship between skin microbiota and hypertrophic scar using bidirectional mendelian randomization","authors":"Kai Hou ,&nbsp;Yufang Tan ,&nbsp;Qi Zhang","doi":"10.1016/j.burns.2025.107376","DOIUrl":"10.1016/j.burns.2025.107376","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic scar (HS) is acknowledged as a pathological fibro-proliferative disease of the dermis, resulting from excessive connective tissue growth. HS significantly impacts patient quality of life due to both social and functional issues. Despite various treatments, therapeutic effectiveness remains limited, necessitating further exploration of underlying factors and mechanisms.</div></div><div><h3>Objective</h3><div>The current study was designed to determine the causal relationship between skin microbiota and HS employing a bidirectional Mendelian randomization (MR) approach.</div></div><div><h3>Methods</h3><div>We utilized genome-wide association study (GWAS) data from the PopGen cohort and the FinnGen database. Independent single nucleotide polymorphisms (SNPs) linked to the skin microbiota were identified as instrumental variables (IVs) chosen for the two-sample MR analysis. Key analytical approaches included inverse variance weighting (IVW), MR-Egger, simple median, simple mode, and weighted mode, with MR-Egger intercept test and Cochrane’s <em>Q</em> test used to detect potential horizontal pleiotropy and heterogeneity.</div></div><div><h3>Results</h3><div>The two-sample MR analysis identified significant causal relationships between specific skin microbiota features and HS. Notably, <em>Enhydrobacter</em>, <em>Micrococcus</em>, and <em>Acinetobacter</em> on moist skin exhibited protective effects against HS, whereas <em>Finegoldia</em> and <em>Lactobacillales</em> on dry skin were linked to an increased risk of HS. Sensitivity analyses verified the strength of these results, revealing no notable horizontal pleiotropy or heterogeneity.</div></div><div><h3>Conclusion</h3><div>Our research reveals a unidirectional causal relationship between certain skin microbiota and HS, suggesting that modulation of skin microbiota could be a novel therapeutic approach for HS management. These results emphasize the significance of considering skin microbiota in the pathogenesis and treatment of HS.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107376"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}