Pub Date : 2026-02-01Epub Date: 2025-11-08DOI: 10.1016/j.burns.2025.107773
Huijun Zhang, Xiaozhuo Zhao, Xin Chen
Background
The auricle is vulnerable to burn injury because of its anatomical location. Auricular keloids that form after burns can have significant psychosocial and quality-of-life effects. We developed a new surgical technique to treat this type of keloid—the continuous zigzag excision technique—and report our experience here.
Methods
A retrospective clinical study was carried out on consecutive patients with helix keloids who underwent reconstruction using continuous zigzag excision between January 2018 and December 2023. The data analyzed included patients’ medical history, physical examination findings, ear photographs, surgical information, and pre- and post-operative Vancouver scar scale (VSS) scores, along with patient satisfaction.
Results
A total of 24 patients with 36 helix keloids were included in the study. Among them, 18 patients with 28 helix keloids (77.8 %) were either satisfied or very satisfied with their postoperative outcomes. Three patients with 4 helix keloids (11.1 %) felt neutral since the shape of their ears after the surgery did not match their ideal expectations; however, they experienced relief from itching and pain, and were not interested in additional treatments. Three patients with 4 helix keloids (11.1 %) were dissatisfied because of keloid recurrence, which resolved with radiotherapy or steroid injections. The mean postoperative VSS score was significantly lower than the preoperative score (P < 0.01).
Conclusion
The continuous zigzag excision technique is effective for treating keloids of the helix caused by burn injury. This method can achieve good cosmetic results with minimal complications and a relatively low rate of recurrence without other additional treatments.
{"title":"Continuous zigzag excision: A surgical technique for keloids of the auricular helix after burn injury","authors":"Huijun Zhang, Xiaozhuo Zhao, Xin Chen","doi":"10.1016/j.burns.2025.107773","DOIUrl":"10.1016/j.burns.2025.107773","url":null,"abstract":"<div><h3>Background</h3><div>The auricle is vulnerable to burn injury because of its anatomical location. Auricular keloids that form after burns can have significant psychosocial and quality-of-life effects. We developed a new surgical technique to treat this type of keloid—the continuous zigzag excision technique—and report our experience here.</div></div><div><h3>Methods</h3><div>A retrospective clinical study was carried out on consecutive patients with helix keloids who underwent reconstruction using continuous zigzag excision between January 2018 and December 2023. The data analyzed included patients’ medical history, physical examination findings, ear photographs, surgical information, and pre- and post-operative Vancouver scar scale (VSS) scores, along with patient satisfaction.</div></div><div><h3>Results</h3><div>A total of 24 patients with 36 helix keloids were included in the study. Among them, 18 patients with 28 helix keloids (77.8 %) were either satisfied or very satisfied with their postoperative outcomes. Three patients with 4 helix keloids (11.1 %) felt neutral since the shape of their ears after the surgery did not match their ideal expectations; however, they experienced relief from itching and pain, and were not interested in additional treatments. Three patients with 4 helix keloids (11.1 %) were dissatisfied because of keloid recurrence, which resolved with radiotherapy or steroid injections. The mean postoperative VSS score was significantly lower than the preoperative score (<em>P</em> < 0.01).</div></div><div><h3>Conclusion</h3><div>The continuous zigzag excision technique is effective for treating keloids of the helix caused by burn injury. This method can achieve good cosmetic results with minimal complications and a relatively low rate of recurrence without other additional treatments.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107773"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-25DOI: 10.1016/j.burns.2025.107809
Wenqi Lv, Xiaoyan Yan
{"title":"Comment on: \"Use of selective decontamination of the digestive tract in burn patients – A European survey\"","authors":"Wenqi Lv, Xiaoyan Yan","doi":"10.1016/j.burns.2025.107809","DOIUrl":"10.1016/j.burns.2025.107809","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107809"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study aims to determine the experiences of patients who suffer from post-burn pruritus and to evaluate the effect of pruritus on their quality of life.
Method
The research employed a mixed-methods approach, combining both quantitative and qualitative methods. The study was carried out at the burn center of a city hospital in Istanbul. Individuals aged 18 and over who suffered burns after April 15, 2019, and continued to experience pruritus complaints were included in the study. A total of 120 patients were included in the quantitative phase of the study. Data for the quantitative phase were collected using the Patient Information Form, the Pruritus Information Collection Form, the 12-Item Pruritus Severity Scale, and the Burn-Specific Health Scale between July 2019 and March 2020. The qualitative phase was conducted between August 2019 and February 2020, concurrently with the collection of quantitative data. In the qualitative phase, in-depth face-to-face interviews were carried out with 11 individuals using a Semi-Structured Interview Form.
Results
It was determined that the patients experienced pruritus ranging from mild to severe (3.00–19.00), with the average pruritus score indicating moderate severity (8.91 ± 3.90). Significant differences were found between groups in terms of pruritus severity based on length of hospital stay, depth of burn, total body surface area burned, burned body region, and the presence of grafts (p < 0.05). In the in-depth interviews, it was found that burn patients struggled to cope with pruritus, that pruritus had an impact on their daily and family lives, and that it had physical, social, and psychological effects. Additionally, patients reported experiences related to the treatment of pruritus.
Conclusion
This study demonstrated that as the severity, distribution, and persistence of pruritus increased, it was perceived by patients as an unbearable symptom; and that pruritus is a significant factor reducing the quality of life in burn patients. It is suggested that the proper evaluation of pruritus using objective measurement tools, the development of appropriate protocols for the treatment and follow-up of post-burn pruritus, and providing education and counseling services to help burn patients cope with pruritus could improve the quality of life for burn patients experiencing pruritus.
{"title":"Evaluation of the effect of post-burn pruritus on patients' quality of life and experiences","authors":"Handan Aktas , Zahide Tuncbilek , Seyhan Hidiroğlu","doi":"10.1016/j.burns.2025.107808","DOIUrl":"10.1016/j.burns.2025.107808","url":null,"abstract":"<div><h3>Objective</h3><div>The study aims to determine the experiences of patients who suffer from post-burn pruritus and to evaluate the effect of pruritus on their quality of life.</div></div><div><h3>Method</h3><div>The research employed a mixed-methods approach, combining both quantitative and qualitative methods. The study was carried out at the burn center of a city hospital in Istanbul. Individuals aged 18 and over who suffered burns after April 15, 2019, and continued to experience pruritus complaints were included in the study. A total of 120 patients were included in the quantitative phase of the study. Data for the quantitative phase were collected using the Patient Information Form, the Pruritus Information Collection Form, the 12-Item Pruritus Severity Scale, and the Burn-Specific Health Scale between July 2019 and March 2020. The qualitative phase was conducted between August 2019 and February 2020, concurrently with the collection of quantitative data. In the qualitative phase, in-depth face-to-face interviews were carried out with 11 individuals using a Semi-Structured Interview Form.</div></div><div><h3>Results</h3><div>It was determined that the patients experienced pruritus ranging from mild to severe (3.00–19.00), with the average pruritus score indicating moderate severity (8.91 ± 3.90). Significant differences were found between groups in terms of pruritus severity based on length of hospital stay, depth of burn, total body surface area burned, burned body region, and the presence of grafts (p < 0.05). In the in-depth interviews, it was found that burn patients struggled to cope with pruritus, that pruritus had an impact on their daily and family lives, and that it had physical, social, and psychological effects. Additionally, patients reported experiences related to the treatment of pruritus.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that as the severity, distribution, and persistence of pruritus increased, it was perceived by patients as an unbearable symptom; and that pruritus is a significant factor reducing the quality of life in burn patients. It is suggested that the proper evaluation of pruritus using objective measurement tools, the development of appropriate protocols for the treatment and follow-up of post-burn pruritus, and providing education and counseling services to help burn patients cope with pruritus could improve the quality of life for burn patients experiencing pruritus.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107808"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-17DOI: 10.1016/j.burns.2025.107786
Da Huang , Yan Zheng , Ming Xu , Wenying Huang
Objective
This study aimed to systematically evaluate the efficacy of robot-assisted training (RAT) in improving the physical rehabilitation outcomes of burn patients and to establish a clinical basis for its broader application.
Methods
Randomized controlled trials (RCTs) investigating the use of RAT in burns rehabilitation were searched from PubMed, Embase, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Data (WanFang), and Chinese BioMedical Literature Database (CBM) databases (as of March 18, 2025). The quality of the study was assessed using the Cochrane risk of bias tool. Analyses were performed using RevMan 5.3, and data that could not be synthesized were presented in a descriptive manner.
Results
Nine RCTs, involving 531 patients, were included. RAT significantly improved hand grip strength (MD=1.2, 95 % CI: 0.21–2.19, p = 0.02) and lower limb 6-minute walking distance (6MWT: MD=73.06, 95 % CI: 1.18–144.93, p = 0.05). However, no significant differences were observed in Functional Ambulation Category (FAC) scores (MD=0.4, 95 % CI: −0.09–0.9, p = 0.11) or pain reduction (MD=0.29, 95 % CI: −0.22–0.8, p = 0.26). The certainty of all the evidence was shown to be very low. Multiple descriptive statistical analysis highlighted RAT’s superiority in enhancing finger mobility, hand dexterity, and select gait parameters.
Conclusions
Our systematic review suggests that incorporating RAT into conventional physiotherapy may offer some benefits for the functional rehabilitation of upper and lower limbs in burn patients; however, the certainty of the evidence supporting this recommendation is very low. Consequently, high-quality research is required to validate the efficacy of RAT in future studies.
目的系统评价机器人辅助训练(robot-assisted training, RAT)改善烧伤患者肢体康复效果的效果,为其广泛应用奠定临床基础。方法从PubMed、Embase、Web of Science、Scopus、Cochrane图书馆、中国知网(CNKI)、万方数据(WanFang Data)和中国生物医学文献数据库(CBM)检索截至2025年3月18日的研究RAT在烧伤康复中的应用的随机对照试验(RCTs)。使用Cochrane偏倚风险工具评估研究质量。使用RevMan 5.3进行分析,无法合成的数据以描述性方式呈现。结果纳入9项随机对照试验,共531例患者。大鼠显著改善了手部握力(MD=1.2, 95 % CI: 0.21-2.19, p = 0.02)和下肢6分钟步行距离(6MWT: MD=73.06, 95 % CI: 1.18-144.93, p = 0.05)。然而,在功能活动类别(FAC)评分(MD=0.4, 95 % CI: - 0.09-0.9, p = 0.11)或疼痛减轻(MD=0.29, 95 % CI: - 0.22-0.8, p = 0.26)方面没有观察到显著差异。所有证据的确定性都很低。多重描述性统计分析表明RAT在增强手指活动能力、手部灵巧性和选择步态参数方面具有优势。结论我们的系统评价表明,将大鼠纳入常规物理治疗对烧伤患者的上肢和下肢功能康复有一定的益处;然而,支持这一建议的证据的确定性非常低。因此,在未来的研究中,需要高质量的研究来验证RAT的有效性。
{"title":"The effect of robot-assisted training on burn rehabilitation: A systematic review and meta-analysis","authors":"Da Huang , Yan Zheng , Ming Xu , Wenying Huang","doi":"10.1016/j.burns.2025.107786","DOIUrl":"10.1016/j.burns.2025.107786","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to systematically evaluate the efficacy of robot-assisted training (RAT) in improving the physical rehabilitation outcomes of burn patients and to establish a clinical basis for its broader application.</div></div><div><h3>Methods</h3><div>Randomized controlled trials (RCTs) investigating the use of RAT in burns rehabilitation were searched from PubMed, Embase, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Data (WanFang), and Chinese BioMedical Literature Database (CBM) databases (as of March 18, 2025). The quality of the study was assessed using the Cochrane risk of bias tool. Analyses were performed using RevMan 5.3, and data that could not be synthesized were presented in a descriptive manner.</div></div><div><h3>Results</h3><div>Nine RCTs, involving 531 patients, were included. RAT significantly improved hand grip strength (MD=1.2, 95 % CI: 0.21–2.19, p = 0.02) and lower limb 6-minute walking distance (6MWT: MD=73.06, 95 % CI: 1.18–144.93, p = 0.05). However, no significant differences were observed in Functional Ambulation Category (FAC) scores (MD=0.4, 95 % CI: −0.09–0.9, p = 0.11) or pain reduction (MD=0.29, 95 % CI: −0.22–0.8, p = 0.26). The certainty of all the evidence was shown to be very low. Multiple descriptive statistical analysis highlighted RAT’s superiority in enhancing finger mobility, hand dexterity, and select gait parameters.</div></div><div><h3>Conclusions</h3><div>Our systematic review suggests that incorporating RAT into conventional physiotherapy may offer some benefits for the functional rehabilitation of upper and lower limbs in burn patients; however, the certainty of the evidence supporting this recommendation is very low. Consequently, high-quality research is required to validate the efficacy of RAT in future studies.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107786"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-16DOI: 10.1016/j.burns.2025.107784
Sarah Smailes , Catherine Wharfe
Introduction
Identifying valid and reliable instruments to measure physical function is key to standardising outcome reporting and improving patient care in adult burn survivors. The Functional Assessment for Burns (FAB) score is predictive of discharge outcome in adult burn inpatients and is used in routine clinical practice by therapists. The aim of this study was to assess the interrater reliability of the FAB score when used by different members of the inpatient rehabilitation team.
Objectives
This research aimed to evaluate the interrater reliability of the FAB score.
Methods
A prospective observational study assessed the interrater reliability of the FAB score when used by three different therapists simultaneously rating the same patient-scoring episode (n = 22).
Results
The Intraclass Correlation Coefficient (ICC) for the FAB score as a complete tool revealed excellent agreement (ICC 0.999, P < 0.001, 95 % confidence interval 0.999 – 0.999), with Cronbach’s alpha 0.999. Individual components of the FAB score revealed excellent agreement (ICC > 0.983, P < 0.001) with narrow 95 % confidence intervals.
Conclusion
The FAB score is the first physical functional outcome measure developed specifically for patients on the burns ward to have demonstrated both interrater reliability and, based on our previous work, predictive validity. The overall FAB assessment, as well as its individual domains, showed excellent interrater reliability, supporting its utility in this patient population.
确定有效和可靠的仪器来测量身体功能是标准化结果报告和改善成人烧伤幸存者患者护理的关键。烧伤功能评估(FAB)评分可预测成人烧伤住院患者的出院结果,并被治疗师用于常规临床实践。本研究的目的是评估不同住院康复团队成员使用FAB评分时的互译信度。目的评价FAB评分的被测者信度。方法一项前瞻性观察性研究评估了三名不同治疗师同时对同一患者评分事件进行评分时FAB评分的间信度(n = 22)。结果FAB评分的类内相关系数(ICC)作为一个完整的工具显示出极好的一致性(ICC 0.999, P <; 0.001,95 %置信区间0.999 - 0.999),Cronbach 's alpha 0.999。FAB评分的各个组成部分显示出极好的一致性(ICC > 0.983, P <; 0.001),置信区间窄至95 %。FAB评分是第一个专门为烧伤病房的患者开发的身体功能结果测量,它既证明了相互间的可靠性,也证明了基于我们之前的工作的预测有效性。总体FAB评估,以及它的个别领域,显示出出色的相互可靠性,支持其在该患者群体中的效用。
{"title":"Testing the interrater reliability of the Functional Assessment for Burns (FAB) score in adult burn inpatients","authors":"Sarah Smailes , Catherine Wharfe","doi":"10.1016/j.burns.2025.107784","DOIUrl":"10.1016/j.burns.2025.107784","url":null,"abstract":"<div><h3>Introduction</h3><div>Identifying valid and reliable instruments to measure physical function is key to standardising outcome reporting and improving patient care in adult burn survivors. The Functional Assessment for Burns (FAB) score is predictive of discharge outcome in adult burn inpatients and is used in routine clinical practice by therapists. The aim of this study was to assess the interrater reliability of the FAB score when used by different members of the inpatient rehabilitation team.</div></div><div><h3>Objectives</h3><div>This research aimed to evaluate the interrater reliability of the FAB score.</div></div><div><h3>Methods</h3><div>A prospective observational study assessed the interrater reliability of the FAB score when used by three different therapists simultaneously rating the same patient-scoring episode (<em>n</em> = 22).</div></div><div><h3>Results</h3><div>The Intraclass Correlation Coefficient (ICC) for the FAB score as a complete tool revealed excellent agreement (ICC 0.999, <em>P</em> < 0.001, 95 % confidence interval 0.999 – 0.999), with Cronbach’s alpha 0.999. Individual components of the FAB score revealed excellent agreement (ICC > 0.983, <em>P</em> < 0.001) with narrow 95 % confidence intervals.</div></div><div><h3>Conclusion</h3><div>The FAB score is the first physical functional outcome measure developed specifically for patients on the burns ward to have demonstrated both interrater reliability and, based on our previous work, predictive validity. The overall FAB assessment, as well as its individual domains, showed excellent interrater reliability, supporting its utility in this patient population.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107784"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-20DOI: 10.1016/j.burns.2025.107802
Nicholas D. Soulakis , Caroline Hensing , Annabelle Shaffer , David Gonzalez-Velez , Ashley A. Peters , Nathan Pecoraro , Paul M. Arnold
Introduction
Burn injuries cause significant morbidity and mortality. By better understanding the epidemiology and seasonality of such injuries, burn education and prevention efforts can be improved. The purpose of this investigation is to provide an update to the epidemiology of burn injuries in the United States (US).
Methods
This retrospective study analyzes data from the National Electronic Injury Surveillance System (NEISS) from 2014 to 2023. The NEISS collects data on emergency department visits from approximately 100 hospitals throughout the US. Data were analyzed using R version 4.4.3. to calculate annual burn estimates, injury rates, frequencies and acute periods of increased incidence.
Results
Between 2014 and 2023, emergency departments in the US treated an average of 206,856 burn injuries annually. These injuries occurred mainly in the home (66.8 %) and in males (53.1 %), with a peak incidence in children under 5 (20.6 %). This study found no significant increasing or decreasing trends in incidence over time; however, burn injury incidence and associated products fluctuated based on season, with an increased incidence occurring around July 4th.
Conclusion
Burn injuries significantly affect the US population. Public health and primary care workers may utilize information provided by this study to better target patient education on burn injury prevention.
{"title":"Epidemiology of emergency department visits for burn injuries in the United States, 2014–2023","authors":"Nicholas D. Soulakis , Caroline Hensing , Annabelle Shaffer , David Gonzalez-Velez , Ashley A. Peters , Nathan Pecoraro , Paul M. Arnold","doi":"10.1016/j.burns.2025.107802","DOIUrl":"10.1016/j.burns.2025.107802","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn injuries cause significant morbidity and mortality. By better understanding the epidemiology and seasonality of such injuries, burn education and prevention efforts can be improved. The purpose of this investigation is to provide an update to the epidemiology of burn injuries in the United States (US).</div></div><div><h3>Methods</h3><div>This retrospective study analyzes data from the National Electronic Injury Surveillance System (NEISS) from 2014 to 2023. The NEISS collects data on emergency department visits from approximately 100 hospitals throughout the US. Data were analyzed using R version 4.4.3. to calculate annual burn estimates, injury rates, frequencies and acute periods of increased incidence.</div></div><div><h3>Results</h3><div>Between 2014 and 2023, emergency departments in the US treated an average of 206,856 burn injuries annually. These injuries occurred mainly in the home (66.8 %) and in males (53.1 %), with a peak incidence in children under 5 (20.6 %). This study found no significant increasing or decreasing trends in incidence over time; however, burn injury incidence and associated products fluctuated based on season, with an increased incidence occurring around July 4th.</div></div><div><h3>Conclusion</h3><div>Burn injuries significantly affect the US population. Public health and primary care workers may utilize information provided by this study to better target patient education on burn injury prevention.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107802"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-03DOI: 10.1016/j.burns.2025.107818
Lu Cen
{"title":"Comments on “Association between platelet‑to‑lymphocyte ratio at admission and short‑term mortality in severe burn patients”","authors":"Lu Cen","doi":"10.1016/j.burns.2025.107818","DOIUrl":"10.1016/j.burns.2025.107818","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107818"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with high mortality and morbidity. Early prognostic assessment is crucial for improving clinical outcomes. This retrospective study aimed to identify and evaluate potential plasma biomarkers for NF poor prognosis. Data from 109 NF patients admitted between 2015 and 2025 were analyzed, with 78 in the favorable prognosis group (recovery) and 31 in the adverse group (amputation or death). Laboratory markers, including inflammatory, coagulation, and metabolic parameters, were assessed within 24 h of admission. Multivariate logistic regression identified albumin-to-globulin ratio (AGR) as an independent protective factor (OR = 0.028, 95 % CI: 0.002-0.373, p = 0.007), and both diabetes history and neutrophil percentage (NEUT%) as risk factors (OR = 4.387, 95 % CI: 1.234-15.601, p = 0.022; OR = 1.103, 95 % CI: 1.008-1.207, p = 0.033, respectively). The activated partial thromboplastin time (APTT) showed only borderline significance. ROC analysis revealed AGR had the highest predictive value (AUC = 0.803, cutoff = 1.205), followed by NEUT% (AUC = 0.733, cutoff = 31.450). The study highlights AGR and NEUT% as promising biomarkers for NF prognosis, reflecting the interplay of inflammation, nutrition, metabolism, and coagulation. These findings advocate for integrating multi-dimensional markers to enhance early risk stratification and guide targeted interventions. Limitations include the single-center retrospective design and limitations of the dataset; future multicenter studies are needed for validation.
坏死性筋膜炎(NF)是一种危及生命的软组织感染,死亡率和发病率高。早期预后评估对改善临床结果至关重要。本回顾性研究旨在识别和评估NF不良预后的潜在血浆生物标志物。分析了2015年至2025年间收治的109例NF患者的数据,其中预后良好组(恢复)78例,不良组(截肢或死亡)31例。入院后24 h内评估实验室标志物,包括炎症、凝血和代谢参数。多元逻辑回归确定albumin-to-globulin比(AGR)作为一个独立的保护因素(或= 0.028,95 % CI: 0.002 - -0.373, p = 0.007),糖尿病史和中性粒细胞百分比(中性粒细胞%)作为风险因素(或= 4.387,95 % CI: 1.234 - -15.601, p = 0.022;或= 1.103,95 % CI: 1.008 - -1.207, p = 0.033,分别)。活化的部分凝血活素时间(APTT)仅具有边缘性意义。ROC分析显示,AGR的预测值最高(AUC = 0.803, cut - off = 1.205),其次为NEUT% (AUC = 0.733, cut - off = 31.450)。该研究强调AGR和NEUT%是NF预后的有希望的生物标志物,反映了炎症、营养、代谢和凝血的相互作用。这些发现提倡整合多维标记,以加强早期风险分层和指导有针对性的干预措施。局限性包括单中心回顾性设计和数据集的局限性;需要未来的多中心研究来验证。
{"title":"Albumin-to-globulin ratio and neutrophil percentage as predictive markers for necrotizing fasciitis prognosis.","authors":"Yuchen Fan, Zixin Chai, Xiang Li, Lu Wang, Zexin Chen, Fengqin Miao, Shaolei Ma, Fangfang Guo","doi":"10.1016/j.burns.2026.107876","DOIUrl":"https://doi.org/10.1016/j.burns.2026.107876","url":null,"abstract":"<p><p>Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with high mortality and morbidity. Early prognostic assessment is crucial for improving clinical outcomes. This retrospective study aimed to identify and evaluate potential plasma biomarkers for NF poor prognosis. Data from 109 NF patients admitted between 2015 and 2025 were analyzed, with 78 in the favorable prognosis group (recovery) and 31 in the adverse group (amputation or death). Laboratory markers, including inflammatory, coagulation, and metabolic parameters, were assessed within 24 h of admission. Multivariate logistic regression identified albumin-to-globulin ratio (AGR) as an independent protective factor (OR = 0.028, 95 % CI: 0.002-0.373, p = 0.007), and both diabetes history and neutrophil percentage (NEUT%) as risk factors (OR = 4.387, 95 % CI: 1.234-15.601, p = 0.022; OR = 1.103, 95 % CI: 1.008-1.207, p = 0.033, respectively). The activated partial thromboplastin time (APTT) showed only borderline significance. ROC analysis revealed AGR had the highest predictive value (AUC = 0.803, cutoff = 1.205), followed by NEUT% (AUC = 0.733, cutoff = 31.450). The study highlights AGR and NEUT% as promising biomarkers for NF prognosis, reflecting the interplay of inflammation, nutrition, metabolism, and coagulation. These findings advocate for integrating multi-dimensional markers to enhance early risk stratification and guide targeted interventions. Limitations include the single-center retrospective design and limitations of the dataset; future multicenter studies are needed for validation.</p>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 4","pages":"107876"},"PeriodicalIF":2.9,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burns are the fourth most common accidental injury worldwide, predominantly occurring in developing countries. Wound healing in burns involves reduced cytokine secretion but increased chemokine and growth factor production compared to surgical wounds. Keratinocyte growth factor (KGF) regulates epidermal regeneration, an essential process in wound healing; while epidermal stem cells (ESCs) play a crucial role in wound closure and have potential for cell therapy. Negative pressure wound therapy (NPWT) promotes healing by improving blood flow, enhancing re-epithelialization, and reducing infection risk. This study investigates the effects of NaCl 0.9 %, intermittent and continuous NPWT, and silver sulfadiazine on ESC and KGF levels in deep dermal burns.
Method
Six male Yorkshire pigs received 20 deep dermal burns on the flank and dorsum, divided into four treatment groups: NaCl 0.9 %, continuous NPWT, intermittent NPWT, and silver sulfadiazine. Samples were collected on days 1, 3, 7, 14, and 21. ESCs were evaluated using CK19 immunohistochemistry as a marker. KGF levels were measured via ELISA. Data were analyzed with ANOVA, with significance set at p < 0.05.
Result
Continuous NPWT showed the highest ESC counts at the wound edge on all observation days and at the wound center on days 3 and 21, though without statistical significance. KGF levels differed significantly among the groups on days 1, 3, and 7 (p < 0.05), with the continuous NPWT group consistently showing the highest KGF levels. Statistical analysis revealed that treatment, observation day, and KGF levels significantly influenced ESC counts, accounting for 45 % of the variability (p < 0.05).
Conclusion
The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings.
{"title":"The impact of negative pressure wound therapy on epidermal stem cells and keratinocyte growth factor in deep dermal burn injury: An experimental study","authors":"Muhammad Rosadi Seswandhana , Hamim Majdy Awliya Humani , Gita Christy Gabriela , Ishandono Dachlan , Estelita Liana , Yohanes Widodo Wirohadidjojo , Teguh Aryandono , Budi Mulyono , Irianiwati Widodo","doi":"10.1016/j.burns.2025.107719","DOIUrl":"10.1016/j.burns.2025.107719","url":null,"abstract":"<div><h3>Introduction</h3><div>Burns are the fourth most common accidental injury worldwide, predominantly occurring in developing countries. Wound healing in burns involves reduced cytokine secretion but increased chemokine and growth factor production compared to surgical wounds. Keratinocyte growth factor (KGF) regulates epidermal regeneration, an essential process in wound healing; while epidermal stem cells (ESCs) play a crucial role in wound closure and have potential for cell therapy. Negative pressure wound therapy (NPWT) promotes healing by improving blood flow, enhancing re-epithelialization, and reducing infection risk. This study investigates the effects of NaCl 0.9 %, intermittent and continuous NPWT, and silver sulfadiazine on ESC and KGF levels in deep dermal burns.</div></div><div><h3>Method</h3><div>Six male Yorkshire pigs received 20 deep dermal burns on the flank and dorsum, divided into four treatment groups: NaCl 0.9 %, continuous NPWT, intermittent NPWT, and silver sulfadiazine. Samples were collected on days 1, 3, 7, 14, and 21. ESCs were evaluated using CK19 immunohistochemistry as a marker. KGF levels were measured via ELISA. Data were analyzed with ANOVA, with significance set at <em>p</em> < 0.05.</div></div><div><h3>Result</h3><div>Continuous NPWT showed the highest ESC counts at the wound edge on all observation days and at the wound center on days 3 and 21, though without statistical significance. KGF levels differed significantly among the groups on days 1, 3, and 7 (<em>p</em> < 0.05), with the continuous NPWT group consistently showing the highest KGF levels. Statistical analysis revealed that treatment, observation day, and KGF levels significantly influenced ESC counts, accounting for 45 % of the variability (<em>p</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107719"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-09-02DOI: 10.1016/j.burns.2025.107679
Song Zhou, Yunlai Zhao, Hongying Wang
{"title":"Comment on \"Lower fluid resuscitation volumes in the first 24 h following a severe burn injury are independently associated with greater days alive and out of hospital: A retrospective cohort study\"","authors":"Song Zhou, Yunlai Zhao, Hongying Wang","doi":"10.1016/j.burns.2025.107679","DOIUrl":"10.1016/j.burns.2025.107679","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107679"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}