Burns最新文献

{"title":"Integra® versus Novosorb® biodegradable temporizing matrix for burn wounds: a comparative systematic review and meta analysis","authors":"Meghan He ,&nbsp;Joanna Choi ,&nbsp;Iman Mir ,&nbsp;Malak Al Wahaiby ,&nbsp;Anthony Papp","doi":"10.1016/j.burns.2025.107754","DOIUrl":"10.1016/j.burns.2025.107754","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Integra® is a bovine-derived artificial dermal matrix (ADM) widely used in the management of burns. More recently, Novosorb® Biodegradable Temporizing Matrix (BTM) has emerged as a fully synthetic ADM product. While experience with Integra® and BTM has been separately reviewed, burn wound healing outcomes and infectious complications have yet to be pooled and compared.</div></div><div><h3>Methods</h3><div>Following librarian-reviewed systematic search, a mixed-effects meta-regression model was fitted based on all studies with ADM type as a categorical moderator. A two-stage individual patient data (IPD) meta-analysis was also conducted.</div></div><div><h3>Results</h3><div>Thirty-five studies were included, the majority of which were non-comparative case series. Nineteen studies provided IPD. 674 patients were treated with Integra® and 288 with BTM. Integration time prior to second stage skin grafting was significantly longer with BTM than Integra® (32.11 vs 18.4 days, p &lt; 0.01). Skin graft take was higher with BTM than Integra® when effects of NPWT use, template size and patient age were adjusted on meta-regression (90.6 vs 77.2 %, p = 0.016). This remained significant on two-stage IPD meta-analysis and exclusion of studies with high risk of bias. Moderator-adjusted infection rate was higher with BTM than Integra® (22.8 vs 2.96 %, p = 0.0072), but no differences were observed in average template take or infection-related reoperation rate. Wound closure rate, defined as &gt; 95 % wound epithelialization, was comparable with BTM and Integra® (96.0 vs 96.5 %, p = 0.81).</div></div><div><h3>Discussion</h3><div>While acknowledging BTM’s prolonged healing timeline with no difference in overall wound closure rate, BTM may offer improved graft take and greater salvageability than Integra® in the event of infection.</div></div><div><h3>Summary and conclusion</h3><div>Very low-quality evidence suggests that BTM is associated with longer integration time and higher graft take when compared to Integra®. Infection rate was higher with BTM than Integra® but there was no difference in template take or need for reoperation. Overall wound closure rates were comparable.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107754"},"PeriodicalIF":2.9,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marriage challenges in single women with burn scars: A qualitative study","authors":"Vahid Naseri-Salahshour ,&nbsp;Mahbobeh Sajadi ,&nbsp;Andrew J. Fournier","doi":"10.1016/j.burns.2025.107759","DOIUrl":"10.1016/j.burns.2025.107759","url":null,"abstract":"<div><h3>Background</h3><div>Burn scars are often considered a significant concern of patients. This study was performed with the aim of explaining the experiences of single women with burn scars regarding marriage.</div></div><div><h3>Methods</h3><div>The present study was a content analysis. Convenience sampling was used to recruit seven single women with burn scars and four mothers of them. Overall, 11 face-to-face, semi-structured, in-depth interviews were conducted. All interviews were audio-recorded and transcribed verbatim. Thematic analysis was performed inductively.</div></div><div><h3>Results</h3><div>In this study, eleven individual in-depth interviews were conducted. The experiences of the participants were presented in three themes: “drowning in absolute despair,” “the unclear prospect of cohabitation,” and “searching for a way to save the life.”</div></div><div><h3>Conclusions</h3><div>The findings of this study provided information that may be used as guidance for health managers to manage female burn victims properly. Research using other methods and designs is recommended to enhance the body of knowledge on the body image of burn victims.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107759"},"PeriodicalIF":2.9,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis-intoxicated patients with small burns require more opioid analgesics in the acute hospitalization period","authors":"Sarah Wang ,&nbsp;Amara Emeh ,&nbsp;Eloise Stanton ,&nbsp;Artur Manasyan ,&nbsp;Deborah Choe ,&nbsp;Jordan Gasho ,&nbsp;Sunnie Wong ,&nbsp;Elizabeth Boudiab ,&nbsp;Maxwell B. Johnson ,&nbsp;Haig A. Yenikomshian ,&nbsp;T. Justin Gillenwater","doi":"10.1016/j.burns.2025.107758","DOIUrl":"10.1016/j.burns.2025.107758","url":null,"abstract":"<div><h3>Introduction</h3><div>Cannabis is often used to alleviate chronic pain, but trauma patients that are cannabis users experience worse postoperative pain and require higher doses of rescue analgesics. This study investigated the association between cannabis use and opioid requirements in burn patients.</div></div><div><h3>Methods</h3><div>A single institution retrospective study was conducted of adult burn patients with &lt; 20 % total body surface area (TBSA) who tested positive for cannabis on admission urine toxicology from 2015 to 2024. These patients were matched in a 1:1 ratio based on age, gender, and TBSA, with cannabis-negative controls. Primary outcomes were pain scores and opioid analgesic requirements in the acute hospitalization period (≤ 14 days).</div></div><div><h3>Results</h3><div>Our study included 76 cannabis-positive patients and 76 controls. No significant differences were found in demographics or clinical characteristics. Analysis showed that cannabis users required more opioid analgesics for dressing changes (24.5 vs 14.1 morphine milligram equivalents (MME)/day, p = 0.031). There was no significant difference between basal, <em>pro re nata</em> (PRN), and total opioid analgesic use. Cannabis users on average had a higher reported pain score (8.88 vs 7.95, p = 0.023).</div></div><div><h3>Conclusions</h3><div>Cannabis users had an increased need for opioid analgesics during dressing changes, as well as higher pain scores, suggesting reduced pain tolerance in this group.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107758"},"PeriodicalIF":2.9,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of numerical cut points for mild, moderate, and severe pain across key subgroups of adults with burn injury in a multicenter cohort study: A Burn Model System investigation","authors":"Gretchen J. Carrougher ,&nbsp;Alyssa M. Bamer ,&nbsp;Caitlin M. Orton ,&nbsp;Maiya I. Pacleb ,&nbsp;Tamara Alcala Dominguez ,&nbsp;Mary Slavin ,&nbsp;Jeffrey C. Schneider ,&nbsp;Haig A. Yenikomshian ,&nbsp;Taylor Powell ,&nbsp;Barclay T. Stewart","doi":"10.1016/j.burns.2025.107755","DOIUrl":"10.1016/j.burns.2025.107755","url":null,"abstract":"<div><h3>Introduction</h3><div>The optimal numerical cut points for mild, moderate, and severe burn pain have previously been reported from a single center. Average burn pain can be categorized as mild (0−2), moderate (3−5), and severe (6−10). These findings inform clinical responses to pain scores and benchmarking for research initiatives. To validate these cut points with a larger, more diverse cohort, we aimed to identify average pain intensity rating scores for <em>mild</em>, <em>moderate</em>, and <em>severe</em> using the Patient Reported Outcome Measures Pain Interference (PROMIS-PI) short form.</div></div><div><h3>Methods</h3><div>Average 11-point pain intensity numerical rating scale (NRS) scores (0−10) and custom PROMIS-PI short forms were administered to adults with burn injury treated at 5 centers across the US at hospital discharge (baseline) and 6, 12, 24 months and 5 years post-injury. To identify pain intensity scores that best represent mild, moderate, and severe pain, F value statistics associated with multiple ANOVA comparisons for mean pain interference scores by various pain intensity cut points were computed. Based on previous research, 6 possible cut points (CP) were compared: CP 3,6; 3,7; 4,6; 4,7; 2,5; and 3,5. Cut points in subgroup populations were also examined. The optimal cut points were those with the highest ANOVA F statistics.</div></div><div><h3>Results</h3><div>Data from 1283 participants (58 % male, 79 % White, 22 % Hispanic, mean age 46 years) with NRS pain intensity and PROMIS-PI scores at one or more study timepoints were analyzed. The optimal classification for mild, moderate, and severe pain was CP 2,5 at all timepoints for most adult participants. Sub-analyses were performed based on participant sex, race, ethnicity, self-reported preinjury alcohol use, and site of initial hospitalization.</div></div><div><h3>Conclusions</h3><div>This study confirms that for most adults with burn injury within the US, burn intensity ratings of mild (0−2), moderate (3−5), and severe (6−10) are appropriate. These findings support previous findings and continue to advance our understanding of burn pain and pain intensity reporting while providing clinicians and researchers with an objective measure that can be used for screening, treatment, quality improvement, and research.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107755"},"PeriodicalIF":2.9,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of effect of Ringer’s lactate and isotonic bicarbonate combination therapy with Ringer’s lactate alone in early fluid resuscitation of burns patients – A randomised controlled trial","authors":"Thamizharasan Datchinamourthy ,&nbsp;Shailendra Kumar ,&nbsp;Souvik Maitra ,&nbsp;Sulagna Bhattacharjee ,&nbsp;Nishant Patel ,&nbsp;Rakesh Kumar ,&nbsp;Poornima Diana Ranganathan ,&nbsp;Amit Kumar ,&nbsp;Lokesh Kashyap ,&nbsp;Maneesh Singhal","doi":"10.1016/j.burns.2025.107752","DOIUrl":"10.1016/j.burns.2025.107752","url":null,"abstract":"<div><h3>Background</h3><div>Severe burns cause systemic inflammatory response, capillary leak, and profound metabolic acidosis from both lactic and non-lactic acid sources. Ringer’s lactate (RL) remains the resuscitation standard but isotonic bicarbonate (IB, SID ≈ 150) provides superior alkalinizing capacity. This trial evaluated whether combining IB with RL in a 1:1 ratio improves perfusion compared to RL in early burn resuscitation.</div></div><div><h3>Methods</h3><div>In this single-centre randomized controlled trial, 134 adult patients with ≥ 15 % TBSA burns presenting within 12 h were randomized to receive RL (2 ml/kg/%TBSA; n = 67) or IB+RL (1:1, 2 ml/kg/%TBSA; n = 67) guided by the modified Brooke formula. The primary outcome was 24-hour lactate reduction. Secondary outcomes included acid–base parameters, electrolytes, glucose–insulin profile, renal function, vasopressor use, SOFA scores, and 7-day mortality. Multiplicity correction was applied for secondary endpoints.</div></div><div><h3>Results</h3><div>Median 24-hour lactate reduction was similar between RL [45.9 % (29.1–56.6)] and IB+RL [42.7 % (32.7–58.1); p = 0.752]. Conventional acid–base parameters were comparable, but IB+RL showed greater improvement in standard base excess (BE), alactic base excess (aBE), ΔaBE, ΔeSID, and ΔHCO₃⁻; only ΔHCO₃⁻ and ΔaBE retained borderline significance after multiplicity correction. Electrolyte trends included more hypokalemia and hypocalcemia in IB+RL. Glucose trended higher with IB+RL, but insulin requirements and osmolality remained similar. Fluid requirements, urine output, AKI incidence, vasopressor use, SOFA scores, and 7-day mortality were comparable.</div></div><div><h3>Conclusion</h3><div>Adding IB to RL did not improve perfusion but showed exploratory acid–base benefits without excess harm. Findings are hypothesis-generating and warrant validation in larger multicentre trials with individualized bicarbonate strategies.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107752"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Background pain, procedural pain and optimism are associated with pain post-discharge in burn survivors: A prospective cohort study\"","authors":"Lingli Peng,&nbsp;Hanyang Su","doi":"10.1016/j.burns.2025.107750","DOIUrl":"10.1016/j.burns.2025.107750","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107750"},"PeriodicalIF":2.9,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in the association between inhalation injury and outcomes in inpatients with burns: A nationwide study using the Japanese Burn Registry","authors":"Tatsuya Watanabe ,&nbsp;Yusuke Tsutsumi ,&nbsp;Masao Iwagami ,&nbsp;Yoshiaki Inoue","doi":"10.1016/j.burns.2025.107751","DOIUrl":"10.1016/j.burns.2025.107751","url":null,"abstract":"<div><h3>Background</h3><div>Inhalation injury is a major prognostic factor in burn care; however, its impact may vary with patient age and burn size. This study aimed to evaluate how its association with in-hospital mortality varies by age and percentage of total body surface area burned (%TBSA) among inpatients with burns.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used data from the Japanese Society of Burn Injuries Burn Registry 2011, enrolling 24,065 patients hospitalized for acute burn care between 2011 and 2023. After the exclusion of cases with missing data, 20,982 patients were finally analyzed. The association between inhalation injury and in-hospital mortality was assessed using multivariate logistic regression models with interaction terms between inhalation injury and the categories of %TBSA and age. Additionally, the adjusted predicted mortality and average marginal effects (AMEs) were calculated to quantify the difference in the predicted mortality between patients with and without inhalation injury across the age and %TBSA categories.</div></div><div><h3>Results</h3><div>Of the 20,982 patients included, 4823 (23.0 %) had clinically documented inhalation injury, while 16,159 (77.0 %) did not. Patients with inhalation injury had higher crude in-hospital mortality than those without (22.0 % vs. 5.5 %; <em>p</em> &lt; 0.001). Furthermore, patients with 70 %–79 % TBSA had the greatest difference in adjusted predicted mortality between those with and without inhalation injury (AME: 34.2 %; 95 % confidence interval [CI], 15.8 %–52.5 %). This difference began to increase from the age of 50 years (AME: 3.5 %; 95 % CI, 2.1–4.9), reaching 24.0 % (95 % CI, 12.5–35.5) at the age of 90 years and above.</div></div><div><h3>Conclusions</h3><div>The association between inhalation injury and mortality in patients with burns differs according to patient age and burn size, demonstrating significant heterogeneity. These findings highlight that the prognostic impact of inhalation injury is not uniform across all patients but varies by individual characteristics. Clinicians should consider these variations when interpreting inhalation injury and making individualized treatment decisions.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107751"},"PeriodicalIF":2.9,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Preparation and evaluation of olycaprolactone/chitosan/Jaft biocompatible nanofibers as a burn wound dressing” [Burns 48 (7) 2022 1690–1705]","authors":"Seyedeh-Sara Hashemi ,&nbsp;Zohreh Saadatjo ,&nbsp;Reza Mahmoudi ,&nbsp;Hamdollah Delaviz ,&nbsp;Hassan Bardania ,&nbsp;Seyedeh-Somayeh Rajabi ,&nbsp;Alireza Rafati ,&nbsp;Mohammad M. Zarshenas ,&nbsp;Mehrzad Jafari Barmak","doi":"10.1016/j.burns.2025.107736","DOIUrl":"10.1016/j.burns.2025.107736","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107736"},"PeriodicalIF":2.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions in pediatric burn care still require efforts on multiple fronts","authors":"Lin Luo,&nbsp;Jing Gong","doi":"10.1016/j.burns.2025.107748","DOIUrl":"10.1016/j.burns.2025.107748","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107748"},"PeriodicalIF":2.9,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Multi-omics analysis to explore the molecular mechanisms related to keloid” [Burns 51 (2025) 107396]","authors":"Hailin Xu ,&nbsp;Keai Li ,&nbsp;Xiaofeng Liang ,&nbsp;Zhiyong Wang ,&nbsp;Bin Yang","doi":"10.1016/j.burns.2025.107715","DOIUrl":"10.1016/j.burns.2025.107715","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107715"},"PeriodicalIF":2.9,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}