Burns最新文献

英文中文

Multi-target actions of natural flavonoids in skin flap survival: Opportunities and challenges 天然黄酮类化合物在皮瓣存活中的多靶点作用：机遇与挑战

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-18 DOI: 10.1016/j.burns.2026.107870

Yan-Yan Chen , Yi-Fei Yang , Yu-Yun Xiong, Hui Sun, Yu-Mei Li

引用次数: 0

The diagnostic pitfall of Marjolin's ulcer in old burn scars: When negative biopsy is misleading - A cautionary report. 陈旧性烧伤瘢痕马卓林溃疡的诊断陷阱：当阴性活检具有误导性时——一份警示报告。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-16 DOI: 10.1016/j.burns.2026.107867

Mehdi Ayaz

引用次数: 0

Effects of polymer oxygenated alginate dressings for healing skin graft donor areas: A phase III randomized controlled trial. 聚合物氧合海藻酸盐敷料对皮肤移植供体愈合的影响：一项III期随机对照试验。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-13 DOI: 10.1016/j.burns.2025.107847

Lin Tong, Hanyun Liu, Xuewen Xu, Shun Yu, Yugang Zhu, Ruoheng He, Yong Zou, Yi Zhang, Bin Qu, Guozhong Lyu

Background: Oxygen-generating alginate plays an important therapeutic role in wound treatment. In several studies, oxygen-generating alginate synthetic dressings have been shown to promote wound healing.

Methods: We conducted a multicenter, open-label, phase III randomized clinical trial of split-thickness skin graft donor site treatment. We recruited patients with a burn size of less than 30 % total body surface area (TBSA) who required skin grafting. Patients were randomized into two groups: one group received treatment with polymer oxygenated alginate (POA) dressing (n = 69), and the other group received conventional Vaseline gauze dressing (n = 70). All patients were followed up for a predefined period until the primary outcome was assessed. The primary end point was the wound healing time.

Results: A total of 141 adult patients underwent randomization and 137 completed the trial. Wounds healed faster in the POA group than in the Vaseline gauze group (P < 0.0001). At the first five visits, wound healing rates in the POA group were higher than those in the Vaseline gauze group (P < 0.01). Pain scores were lower ( P = 0.011), and the satisfaction scores were higher (P < 0.05) in the POA group. No significant differences in wound infections and inflammation were detected between the two groups. Two adverse events occurred, but neither was related to the study products or procedures.

Conclusions: Our results demonstrate that POA dressing is safe and clinically effective for treating split-thickness skin graft donor site wounds. It may be effective in controlling wound infection and inflammation; however, further validation is required.

背景：产氧海藻酸盐在创面治疗中起着重要的治疗作用。在几项研究中，产氧海藻酸盐合成敷料已被证明能促进伤口愈合。方法：我们进行了一项多中心、开放标签、III期随机临床试验，用于裂厚皮肤供区移植治疗。我们招募了烧伤面积小于30% %总体表面积（TBSA）需要植皮的患者。将患者随机分为两组，一组采用聚合物氧合海藻酸盐（POA）敷料治疗（n = 69），另一组采用常规凡士林纱布敷料治疗（n = 70）。所有患者随访一段预定的时间，直到评估主要结果。主要终点为伤口愈合时间。结果：共有141名成年患者接受了随机分组，137名完成了试验。结论：POA敷料治疗供皮区裂厚创面是一种安全有效的治疗方法。可有效控制伤口感染和炎症；然而，需要进一步的验证。

{"title":"Effects of polymer oxygenated alginate dressings for healing skin graft donor areas: A phase III randomized controlled trial.","authors":"Lin Tong, Hanyun Liu, Xuewen Xu, Shun Yu, Yugang Zhu, Ruoheng He, Yong Zou, Yi Zhang, Bin Qu, Guozhong Lyu","doi":"10.1016/j.burns.2025.107847","DOIUrl":"https://doi.org/10.1016/j.burns.2025.107847","url":null,"abstract":"<p><strong>Background: </strong>Oxygen-generating alginate plays an important therapeutic role in wound treatment. In several studies, oxygen-generating alginate synthetic dressings have been shown to promote wound healing.</p><p><strong>Methods: </strong>We conducted a multicenter, open-label, phase III randomized clinical trial of split-thickness skin graft donor site treatment. We recruited patients with a burn size of less than 30 % total body surface area (TBSA) who required skin grafting. Patients were randomized into two groups: one group received treatment with polymer oxygenated alginate (POA) dressing (n = 69), and the other group received conventional Vaseline gauze dressing (n = 70). All patients were followed up for a predefined period until the primary outcome was assessed. The primary end point was the wound healing time.</p><p><strong>Results: </strong>A total of 141 adult patients underwent randomization and 137 completed the trial. Wounds healed faster in the POA group than in the Vaseline gauze group (P < 0.0001). At the first five visits, wound healing rates in the POA group were higher than those in the Vaseline gauze group (P < 0.01). Pain scores were lower ( P = 0.011), and the satisfaction scores were higher (P < 0.05) in the POA group. No significant differences in wound infections and inflammation were detected between the two groups. Two adverse events occurred, but neither was related to the study products or procedures.</p><p><strong>Conclusions: </strong>Our results demonstrate that POA dressing is safe and clinically effective for treating split-thickness skin graft donor site wounds. It may be effective in controlling wound infection and inflammation; however, further validation is required.</p>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 3","pages":"107847"},"PeriodicalIF":2.9,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: “Correlation of hemoglobin levels and mortality in burn patients” 评论：《烧伤患者血红蛋白水平与死亡率的相关性》

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-12 DOI: 10.1016/j.burns.2026.107865

François Thuau, Théodore Lahmar, Ugo Lancien, Pierre Perrot

引用次数: 0

The impact of socioeconomic deprivation on the adequacy of burn first aid: a retrospective cohort study 社会经济剥夺对烧伤急救充分性的影响：一项回顾性队列研究

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-12 DOI: 10.1016/j.burns.2026.107864

Man Hin Kong , Alexander J. Baldwin , Ryan Kerstein

Aim

This study aimed to examine the relationship between socioeconomic status, measured by the Index of Multiple Deprivation (IMD), and the adequacy of first aid provided for burn injuries.

Methods

A retrospective cohort study was conducted including all patients (paediatric and adult) treated for thermal burns at a regional burn unit between 1 May and 31 July 2024. Socioeconomic status was assessed using IMD deciles. First aid was categorised as “adequate” (cooling with water for ≥20 min) or “inadequate,” with inadequate first aid further classified as “damaging” (e.g., ice, toothpaste, raw egg) or “not damaging.” Logistic regression analyses adjusted for age, sex, burn aetiology and size of burn.

Results

269 patients were included (median age 28.3 years; 66.9 % adults; 50.9 % male). Scalds were the most common aetiology (59.5 %), and most burns were superficial partial thickness (82.5 %). The median IMD decile was 7 (IQR 5–9). Increasing socioeconomic deprivation (lower IMD decile) was significantly associated with inadequate first aid (OR 0.898 [per unit decrease in IMD decile] 95 % CI 0.807–0.998, p = 0.046). Greater deprivation was also associated with increased odds of harmful first aid practices, compared with adequate first aid (RRR 0.836, 95 % CI 0.737–0.948, p = 0.005).

Conclusion

Socioeconomic deprivation is inversely associated with adequate burn first aid and positively associated with harmful practices. Targeted public health interventions are needed to address this disparity.

目的本研究旨在探讨以多重剥夺指数（Index of Multiple Deprivation， IMD）衡量的社会经济地位与烧伤急救是否充足之间的关系。方法回顾性队列研究，纳入2024年5月1日至7月31日在某地区烧伤科接受热烧伤治疗的所有患者（儿童和成人）。使用IMD十分位数评估社会经济地位。急救被分类为“充分”（用水冷却≥20 min）或“不充分”，不充分的急救进一步被分类为“破坏性”（如冰、牙膏、生鸡蛋）或“无破坏性”。Logistic回归分析调整了年龄、性别、烧伤病因和烧伤大小。结果纳入269例患者，中位年龄28.3岁，成人66.9% ，男性50.9% 。烫伤是最常见的病因（59.5% %），大多数烧伤是浅表部分厚度（82.5% %）。IMD十分位数中位数为7 （IQR 5-9）。社会经济剥夺增加（IMD十分位数较低）与急救不足显著相关（OR 0.898[每单位IMD十分位数下降]95 % CI 0.807-0.998, p = 0.046）。与充分的急救相比，更严重的剥夺也与有害急救做法的几率增加有关（RRR 0.836, 95 % CI 0.737-0.948, p = 0.005）。结论社会经济剥夺与充分的烧伤急救负相关，与有害做法正相关。需要有针对性的公共卫生干预措施来解决这一差距。

{"title":"The impact of socioeconomic deprivation on the adequacy of burn first aid: a retrospective cohort study","authors":"Man Hin Kong , Alexander J. Baldwin , Ryan Kerstein","doi":"10.1016/j.burns.2026.107864","DOIUrl":"10.1016/j.burns.2026.107864","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to examine the relationship between socioeconomic status, measured by the Index of Multiple Deprivation (IMD), and the adequacy of first aid provided for burn injuries.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted including all patients (paediatric and adult) treated for thermal burns at a regional burn unit between 1 May and 31 July 2024. Socioeconomic status was assessed using IMD deciles. First aid was categorised as “adequate” (cooling with water for ≥20 min) or “inadequate,” with inadequate first aid further classified as “damaging” (e.g., ice, toothpaste, raw egg) or “not damaging.” Logistic regression analyses adjusted for age, sex, burn aetiology and size of burn.</div></div><div><h3>Results</h3><div>269 patients were included (median age 28.3 years; 66.9 % adults; 50.9 % male). Scalds were the most common aetiology (59.5 %), and most burns were superficial partial thickness (82.5 %). The median IMD decile was 7 (IQR 5–9). Increasing socioeconomic deprivation (lower IMD decile) was significantly associated with inadequate first aid (OR 0.898 [per unit decrease in IMD decile] 95 % CI 0.807–0.998, p = 0.046). Greater deprivation was also associated with increased odds of harmful first aid practices, compared with adequate first aid (RRR 0.836, 95 % CI 0.737–0.948, p = 0.005).</div></div><div><h3>Conclusion</h3><div>Socioeconomic deprivation is inversely associated with adequate burn first aid and positively associated with harmful practices. Targeted public health interventions are needed to address this disparity.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107864"},"PeriodicalIF":2.9,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Characterization and analysis of the skin mycobiome in keloid: A case-control study 点评：瘢痕疙瘩中皮肤真菌群的特征和分析：一项病例对照研究

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-12 DOI: 10.1016/j.burns.2026.107866

Yan-Yan Chen , Yi-Fei Yang , Yu-Yun Xiong, Hui Sun , Yu-Mei Li

引用次数: 0

Prognostic value of red blood cell distribution width/protein and red blood cell distribution width/platelet count ratios in intensive care burn patients 红血球分布宽度/蛋白和红血球分布宽度/血小板计数比值在重症烧伤患者中的预后价值

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-05 DOI: 10.1016/j.burns.2026.107851

Doha Obed , Huu H. Nguyen , Mustafa Salim , Nadjib Dastagir , Martynas Tamulevicius , Florian Bucher , Anieto O.M. Enechukwu , Peter M. Vogt

Background

Red cell distribution width (RDW), serum protein levels, platelet count (PLT), and RDW/protein and RDW/PLT ratios have been associated with adverse outcomes in various medical conditions such as sepsis and critical illness. This study aimed to investigate the association between these parameters and in-hospital mortality following severe burn injury.

Methods

Intensive care burn patients admitted between March 2007 and December 2020 with a total body surface area (TBSA) burned ≥ 20 % were analyzed. Multivariate analysis was conducted to examine variables associated with mortality. RDW/protein and RDW/PLT ratios on post-burn days 1, 3 and 7 were analyzed by receiver operating characteristic curves.

Results

A total of 288 patients were included. Mortality was 26 %, with non-survivors being significantly older, more frequently male, and presenting with an average of 49 % of TBSA burned. RDW, serum protein levels and PLT were not independent predictive values. The RDW/protein ratios on post-burn days 3 and 7 were significantly associated with in-hospital mortality. The respective AUC value exceeded 0.8 on post-burn day 7, indicating good predictive ability.

Conclusion

Post-burn evaluation of the RDW/protein ratio may provide a simple, cost-effective, and valuable predictor for mortality risk assessment following burn injury.

红细胞分布宽度（RDW）、血清蛋白水平、血小板计数（PLT）、RDW/蛋白和RDW/PLT比值与各种医疗状况（如败血症和危重疾病）的不良结局相关。本研究旨在探讨这些参数与严重烧伤后住院死亡率之间的关系。方法分析2007年3月~ 2020年12月住院的烧伤重症患者，烧伤总体表面积(TBSA)≥ 20 %。进行多变量分析以检查与死亡率相关的变量。通过受试者工作特征曲线分析燃烧后第1、3、7天的RDW/protein和RDW/PLT比值。结果共纳入288例患者。死亡率为26% %，非幸存者明显年龄较大，更常见的是男性，平均为49% %的TBSA烧伤。RDW、血清蛋白水平和PLT不是独立的预测值。烧伤后第3天和第7天的RDW/蛋白质比率与住院死亡率显著相关。烧伤后第7天各AUC值均超过0.8，具有较好的预测能力。结论烧伤后评估RDW/protein比值可为评估烧伤后死亡风险提供一种简单、经济、有价值的预测指标。

{"title":"Prognostic value of red blood cell distribution width/protein and red blood cell distribution width/platelet count ratios in intensive care burn patients","authors":"Doha Obed , Huu H. Nguyen , Mustafa Salim , Nadjib Dastagir , Martynas Tamulevicius , Florian Bucher , Anieto O.M. Enechukwu , Peter M. Vogt","doi":"10.1016/j.burns.2026.107851","DOIUrl":"10.1016/j.burns.2026.107851","url":null,"abstract":"<div><h3>Background</h3><div>Red cell distribution width (RDW), serum protein levels, platelet count (PLT), and RDW/protein and RDW/PLT ratios have been associated with adverse outcomes in various medical conditions such as sepsis and critical illness. This study aimed to investigate the association between these parameters and in-hospital mortality following severe burn injury.</div></div><div><h3>Methods</h3><div>Intensive care burn patients admitted between March 2007 and December 2020 with a total body surface area (TBSA) burned ≥ 20 % were analyzed. Multivariate analysis was conducted to examine variables associated with mortality. RDW/protein and RDW/PLT ratios on post-burn days 1, 3 and 7 were analyzed by receiver operating characteristic curves.</div></div><div><h3>Results</h3><div>A total of 288 patients were included. Mortality was 26 %, with non-survivors being significantly older, more frequently male, and presenting with an average of 49 % of TBSA burned. RDW, serum protein levels and PLT were not independent predictive values. The RDW/protein ratios on post-burn days 3 and 7 were significantly associated with in-hospital mortality. The respective AUC value exceeded 0.8 on post-burn day 7, indicating good predictive ability.</div></div><div><h3>Conclusion</h3><div>Post-burn evaluation of the RDW/protein ratio may provide a simple, cost-effective, and valuable predictor for mortality risk assessment following burn injury.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107851"},"PeriodicalIF":2.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and outcomes of patients who discharge against medical advice from Australian and New Zealand burns services 澳大利亚和新西兰烧伤服务部门不遵医嘱出院患者的特点和结果

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-05 DOI: 10.1016/j.burns.2026.107850

Marcel Chua , Lindsay Damkat-Thomas , Belinda J. Gabbe , Bronwyn Griffin , Courtney Ryder , Lincoln M. Tracy

Burns patients with recorded discharges against medical advice (DAMA) face potential medical and financial consequences associated with future readmissions. This study aimed to investigate the characteristics and outcomes of patients with recorded DAMA from burns services in Australia and New Zealand. In an observational study using data from individuals aged ≥ 16 years captured by the Burns Registry of Australia and New Zealand with a burn-related admission between July 2009 and June 2022, 325 patients (1.4 %) had recorded DAMA. A greater proportion of patients with recorded DAMA were aged 30–44 years, of Australian Aboriginal and Torres Strait Islander origin, from outer regional Australia, had pre-existing mental health conditions, with substance use, and sustained their injury through suspected assault or abuse. Injuries in patients with recorded DAMA were more severe. Compared to patients without DAMA, a greater proportion of patients with DAMA were readmitted within 28 days of discharge (13.8 % versus 4.9 %), with failed discharge processes (45.5 %) and infection (18.2 %) being the most frequently recorded reasons. They required readmission to the intensive care unit (20 % versus 8.6 %) with longer lengths of stay. Outcome findings remained similar in a matched cohort analysis between those with and without recorded DAMA. These findings highlight the consequences of DAMA, necessitating primary measures to address modifiable, cultural, and social factors preemptively to prevent DAMA among disadvantaged individuals, and secondary measures to minimize the impact of DAMA (e.g., adequate pain and wound discharge management, follow-up care, community-based treatments, etc.).

根据医嘱记录出院的烧伤患者（DAMA）面临与未来再入院相关的潜在医疗和经济后果。本研究旨在调查澳大利亚和新西兰烧伤服务中记录的DAMA患者的特征和结果。在一项观察性研究中，澳大利亚和新西兰烧伤登记处收集了2009年7月至2022年6月期间因烧伤相关入院的年龄≥ 16岁的患者的数据，其中325名患者（1.4% %）记录了DAMA。有记录的DAMA患者中，年龄在30-44岁之间的比例较大，为澳大利亚土著和托雷斯海峡岛民，来自澳大利亚外区域，先前存在精神健康问题，使用药物，并因涉嫌袭击或虐待而受伤。记录DAMA的患者损伤更严重。与没有DAMA的患者相比，DAMA患者在出院28天内再次入院的比例更高（13.8 %对4.9 %），出院过程失败（45.5% %）和感染（18.2 %）是最常见的记录原因。他们需要再次入住重症监护室（20 %对8.6 %），住院时间更长。在配对队列分析中，结果发现在有和没有记录DAMA的人群中保持相似。这些研究结果强调了DAMA的后果，需要采取主要措施来应对可改变的、文化的和社会的因素，以先发制人地预防弱势个体的DAMA，并采取次要措施来最大限度地减少DAMA的影响（例如，适当的疼痛和伤口出院管理，随访护理，社区治疗等）。

{"title":"Characteristics and outcomes of patients who discharge against medical advice from Australian and New Zealand burns services","authors":"Marcel Chua , Lindsay Damkat-Thomas , Belinda J. Gabbe , Bronwyn Griffin , Courtney Ryder , Lincoln M. Tracy","doi":"10.1016/j.burns.2026.107850","DOIUrl":"10.1016/j.burns.2026.107850","url":null,"abstract":"<div><div>Burns patients with recorded discharges against medical advice (DAMA) face potential medical and financial consequences associated with future readmissions. This study aimed to investigate the characteristics and outcomes of patients with recorded DAMA from burns services in Australia and New Zealand. In an observational study using data from individuals aged ≥ 16 years captured by the Burns Registry of Australia and New Zealand with a burn-related admission between July 2009 and June 2022, 325 patients (1.4 %) had recorded DAMA. A greater proportion of patients with recorded DAMA were aged 30–44 years, of Australian Aboriginal and Torres Strait Islander origin, from outer regional Australia, had pre-existing mental health conditions, with substance use, and sustained their injury through suspected assault or abuse. Injuries in patients with recorded DAMA were more severe. Compared to patients without DAMA, a greater proportion of patients with DAMA were readmitted within 28 days of discharge (13.8 % versus 4.9 %), with failed discharge processes (45.5 %) and infection (18.2 %) being the most frequently recorded reasons. They required readmission to the intensive care unit (20 % versus 8.6 %) with longer lengths of stay. Outcome findings remained similar in a matched cohort analysis between those with and without recorded DAMA. These findings highlight the consequences of DAMA, necessitating primary measures to address modifiable, cultural, and social factors preemptively to prevent DAMA among disadvantaged individuals, and secondary measures to minimize the impact of DAMA (e.g., adequate pain and wound discharge management, follow-up care, community-based treatments, etc.).</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 3","pages":"Article 107850"},"PeriodicalIF":2.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial and restorative effects of topical hydrogel formulation of Scrofularia striata plant extract on second-degree burn wounds: A clinical trial study. 刺藤植物提取物局部水凝胶配方对二度烧伤创面的抗菌和修复作用：临床试验研究。

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2026-01-03 DOI: 10.1016/j.burns.2026.107849

Zahra Bagheri, Babak Yousefi, Meysam Safi-Keykaleh, Maryam Zand, Amir Larki-Harchegani, Arash Khalili

Background: This study aimed to evaluate the antimicrobial and restorative effects of a topical hydrogel formulation of Scrofularia striata (S. striata) plant extract, Scrofularia Striata Hydrogel (SSH), on superficial partial thickness burn wounds.

Methods: In this randomized, double-blind clinical trial conducted in 2022, 80 patients with superficial partial thickness burns at Besat and Imam Hossein hospitals in Hamadan, Iran, were selected using convenience sampling. Patients were randomly assigned to four groups: SSH+ 1 % SSD, SSH alone, SSD alone, and SSD+Vehicle control (VC). Wound area (mm²) was measured daily using transparent paper tracings analyzed with ImageJ software until complete healing. Data were analyzed using ANOVA, t-test, and Chi-square tests with SPSS software (version 23).

Results: The SSH group exhibited significantly shorter wound healing times (8 days) compared to the SSD+SSH (10 days), SSD alone, and SSD+VC groups (p < 0.001). No infections were reported across all groups.

Conclusion: SSH significantly accelerates the healing of superficial partial thickness burn wounds and is recommended as a promising alternative or adjunct to SSD.

背景：本研究旨在评价一种局部应用的刺蒺藜（S. striata）植物提取物——刺蒺藜水凝胶（SSH）对部分浅烧伤创面的抗菌和修复作用。方法：在这项于2022年进行的随机双盲临床试验中，采用方便抽样的方法选择伊朗哈马丹Besat和Imam Hossein医院的80例浅表部分厚度烧伤患者。患者随机分为4组：SSH+ 1 % SSD、SSH单独、SSD单独、SSD+Vehicle control （VC）。创面面积（mm²）每日用透明纸描痕测量，用ImageJ软件分析，直至完全愈合。数据分析采用方差分析、t检验和卡方检验，采用SPSS软件（版本23）。结果：与SSD+SSH（10天）、单纯SSD和SSD+VC组相比，SSH组创面愈合时间（8天）显著缩短（p ）。结论：SSH可显著加速浅表部分厚度烧伤创面愈合，被推荐为SSD的替代或辅助治疗方法。

{"title":"Antimicrobial and restorative effects of topical hydrogel formulation of Scrofularia striata plant extract on second-degree burn wounds: A clinical trial study.","authors":"Zahra Bagheri, Babak Yousefi, Meysam Safi-Keykaleh, Maryam Zand, Amir Larki-Harchegani, Arash Khalili","doi":"10.1016/j.burns.2026.107849","DOIUrl":"https://doi.org/10.1016/j.burns.2026.107849","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the antimicrobial and restorative effects of a topical hydrogel formulation of Scrofularia striata (S. striata) plant extract, Scrofularia Striata Hydrogel (SSH), on superficial partial thickness burn wounds.</p><p><strong>Methods: </strong>In this randomized, double-blind clinical trial conducted in 2022, 80 patients with superficial partial thickness burns at Besat and Imam Hossein hospitals in Hamadan, Iran, were selected using convenience sampling. Patients were randomly assigned to four groups: SSH+ 1 % SSD, SSH alone, SSD alone, and SSD+Vehicle control (VC). Wound area (mm²) was measured daily using transparent paper tracings analyzed with ImageJ software until complete healing. Data were analyzed using ANOVA, t-test, and Chi-square tests with SPSS software (version 23).</p><p><strong>Results: </strong>The SSH group exhibited significantly shorter wound healing times (8 days) compared to the SSD+SSH (10 days), SSD alone, and SSD+VC groups (p < 0.001). No infections were reported across all groups.</p><p><strong>Conclusion: </strong>SSH significantly accelerates the healing of superficial partial thickness burn wounds and is recommended as a promising alternative or adjunct to SSD.</p>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 3","pages":"107849"},"PeriodicalIF":2.9,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like peptide-1 receptor agonists after recent burn injury are associated with lower rates of infection, mortality, and opioid prescriptions 近期烧伤后胰高血糖素样肽-1受体激动剂与较低的感染率、死亡率和阿片类药物处方相关

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns

Pub Date : 2025-12-29 DOI: 10.1016/j.burns.2025.107848

Matthew Q. Dao , Anika Y. Kim , Sarah Wang , Paul Won , Matteo Laspro , T. Justin Gillenwater , Haig A. Yenikomshian , Maxwell B. Johnson

Introduction

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for glycemic control and weight loss. In addition, these medications have been associated with anti-inflammatory activity, modulation of wound healing, and reduction of substance use disorders. Therefore, GLP-1 RAs may have therapeutic benefits in burn care. This study investigates whether early administration of GLP-1 RAs after burn injury is associated with clinical outcomes.

Methods

The Global Collaborative Network was queried in TriNetX, a database of electronic health records. The treatment group included burn patients who received GLP-1 RAs within 30 days of injury. This group was propensity matched with patients who did not receive GLP-1 RAs. Patients were matched by demographics, comorbidities, and burn characteristics. Outcomes at 90 days and 1 year following burn injury were compared, with statistical significance defined as p < 0.05.

Results

Following matching, each group was composed of 3231 patients. At 90 days post-burn, the GLP-1 RA group had significantly lower rates of soft tissue infection, opioid prescriptions, readmission, and mortality (all p < 0.05). At 1 year post-burn, lower rates of opioid prescriptions, readmission, and mortality persisted (all p < 0.05), while soft tissue infection rates remained numerically lower but did not reach statistical significance. No significant differences were observed for wound disruption, hypertrophic scar formation, or contracture formation at either time point.

Conclusions

GLP-1 RAs after recent burn injury were associated with lower risk of infection, opioid prescriptions, readmission, and mortality. Their utility in burn care is promising, and additional research is needed.

lucagon-like peptide-1 receptor agonists （GLP-1 RAs）被广泛用于血糖控制和减肥。此外，这些药物与抗炎活性、伤口愈合调节和减少物质使用障碍有关。因此，GLP-1 RAs可能在烧伤护理中具有治疗益处。本研究探讨烧伤后早期给予GLP-1 RAs是否与临床结果相关。方法在电子健康档案数据库TriNetX中查询全球协同网络。治疗组包括在伤后30天内接受GLP-1 RAs治疗的烧伤患者。该组与未接受GLP-1 RAs治疗的患者倾向匹配。根据人口统计学、合并症和烧伤特征对患者进行匹配。烧伤后90天和1年的结果比较，p <； 0.05定义为有统计学意义。结果经配对后，每组共3231例患者。烧伤后90天，GLP-1 RA组软组织感染、阿片类药物处方、再入院率和死亡率显著降低（p均为 <； 0.05）。烧伤后1年，较低的阿片类药物处方率、再入院率和死亡率持续存在（p均 <； 0.05），而软组织感染率在数字上仍然较低，但没有达到统计学意义。在两个时间点上，伤口破裂、增生性瘢痕形成或挛缩形成均无显著差异。结论近期烧伤后glp -1 RAs与较低的感染、阿片类药物处方、再入院和死亡率相关。它们在烧伤护理中的应用是有希望的，需要进一步的研究。

{"title":"Glucagon-like peptide-1 receptor agonists after recent burn injury are associated with lower rates of infection, mortality, and opioid prescriptions","authors":"Matthew Q. Dao , Anika Y. Kim , Sarah Wang , Paul Won , Matteo Laspro , T. Justin Gillenwater , Haig A. Yenikomshian , Maxwell B. Johnson","doi":"10.1016/j.burns.2025.107848","DOIUrl":"10.1016/j.burns.2025.107848","url":null,"abstract":"<div><h3>Introduction</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for glycemic control and weight loss. In addition, these medications have been associated with anti-inflammatory activity, modulation of wound healing, and reduction of substance use disorders. Therefore, GLP-1 RAs may have therapeutic benefits in burn care. This study investigates whether early administration of GLP-1 RAs after burn injury is associated with clinical outcomes.</div></div><div><h3>Methods</h3><div>The Global Collaborative Network was queried in TriNetX, a database of electronic health records. The treatment group included burn patients who received GLP-1 RAs within 30 days of injury. This group was propensity matched with patients who did not receive GLP-1 RAs. Patients were matched by demographics, comorbidities, and burn characteristics. Outcomes at 90 days and 1 year following burn injury were compared, with statistical significance defined as p < 0.05.</div></div><div><h3>Results</h3><div>Following matching, each group was composed of 3231 patients. At 90 days post-burn, the GLP-1 RA group had significantly lower rates of soft tissue infection, opioid prescriptions, readmission, and mortality (all p < 0.05). At 1 year post-burn, lower rates of opioid prescriptions, readmission, and mortality persisted (all p < 0.05), while soft tissue infection rates remained numerically lower but did not reach statistical significance. No significant differences were observed for wound disruption, hypertrophic scar formation, or contracture formation at either time point.</div></div><div><h3>Conclusions</h3><div>GLP-1 RAs after recent burn injury were associated with lower risk of infection, opioid prescriptions, readmission, and mortality. Their utility in burn care is promising, and additional research is needed.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107848"},"PeriodicalIF":2.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Burns

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀