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Preparation, properties and biomedical applications progress of 1D magnetic nanomaterials with iron 含铁一维磁性纳米材料的制备、特性和生物医学应用进展
Q3 Engineering Pub Date : 2023-12-20 DOI: 10.1049/bsb2.12073
Zhongbing Huang, Juan Wang, Ximing Pu, Guangfu Yin
1D magnetic nanomaterials with iron, with the special physical properties and biological behaviour, have been found to possess the great promising applications in many fields. In this review, the components, structure, physicochemical properties, biocompatibility and in vitro and in vivo biomedical functions of magnetic nanowires (MNWs), nanorods (MNRs) with iron are summarised, especially their anisotropy shape and magnetism result in their many applications in biodetections and medical treatment fields. The potential future functions of these 1D magnetic nanomaterials compared to magnetic nanoparticles also is discussed by highlighting the possibility of integration with other metal‐compositions or bio‐compositions and with existing biotechnology as well as by pointing out their specific properties. Current limitations in the property improvement and issues related with the outcome of the MNRs in the body are also summarised in order to address the remaining challenge for the extended biomedical functions of MNRs in the clinical application field.
含铁的一维磁性纳米材料具有特殊的物理性质和生物行为,在许多领域都具有广阔的应用前景。在这篇综述中,总结了含铁的磁性纳米线(MNWs)、纳米棒(MNRs)的成分、结构、理化性质、生物相容性和体内外生物医学功能,特别是它们的各向异性形状和磁性使其在生物检测和医疗领域得到广泛应用。与磁性纳米颗粒相比,这些一维磁性纳米材料未来的潜在功能也得到了讨论,强调了与其他金属成分或生物成分以及现有生物技术整合的可能性,并指出了它们的特殊性质。此外,还总结了目前在改善磁性纳米材料特性方面存在的局限性以及与磁性纳米材料在体内的结果有关的问题,以解决在临床应用领域扩展磁性纳米材料的生物医学功能所面临的挑战。
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引用次数: 0
Improving anti‐Gram‐positive‐bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non‐antibiotic lysozyme and parathyroid hormone 通过贻贝模拟多巴胺与非抗生素溶菌酶和甲状旁腺激素改善锌合金的抗革兰氏阳性菌性能和成骨作用
Q3 Engineering Pub Date : 2023-12-04 DOI: 10.1049/bsb2.12072
Deren Zhao, Tianhao Chen, Jinqian Chen, Banglun Huang, Jihua Nie, Hulin Liu, Yangkai Liu, Zilin Chen, Feng Zou, Qiqi Lu, Xiaodong Tan, Yunjie Xiang, Jing Li, Yongping Zhang, Xue Feng, X. Rao
In this work, a novel coating with a non‐antibiotic agent for inhibiting Gram‐positive bacteria and promoting osteogenesis was prepared on zinc‐aluminium alloy (ZA6‐1) via mussel mimetic polydopamine (PDA) containing lysozyme (LYS) and parathyroid hormone (PTH). The results indicate that as‐deposited coatings can efficiently decrease the degradation rate of ZA6‐1 from 0.52 to 0.16 mm/year, and the addition of LYS weakens the coating resistance, while the addition of PTH enhances the coating resistance. In spite that no obvious inhibition of Escherichia coli is observed, the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus. Compared with ZA6‐1 zinc alloys, the increase of antibacterial efficacy reaches 86.9%–90.1%. Furthermore, the lower hydrophilicity (26.4°), higher osteoblast cell viability (>100%), good osteoblast cell morphology and better osteoblast cell differentiation (ALP = 107.7%) for PDA‐LYS/PTH coated samples support that as‐prepared coating is promising for modifying biodegradable zinc implants.
本研究利用含溶菌酶(LYS)和甲状旁腺激素(PTH)的仿贻贝聚多巴胺(PDA)在锌铝合金(ZA6‐1)表面制备了一种具有抑制革兰氏阳性细菌和促进成骨作用的非抗生素涂层。结果表明,as -沉积涂层能有效地将ZA6 - 1的降解速率从0.52 mm/年降低到0.16 mm/年,LYS的加入降低了涂层的耐蚀性,PTH的加入提高了涂层的耐蚀性。尽管对大肠杆菌没有明显的抑制作用,但包覆锌合金对金黄色葡萄球菌有良好的体外抗菌性能。与ZA6‐1锌合金相比,抗菌效果提高86.9% ~ 90.1%。此外,PDA‐LYS/PTH涂层样品具有较低的亲水性(26.4°)、较高的成骨细胞活力(>100%)、良好的成骨细胞形态和较好的成骨细胞分化(ALP = 107.7%),表明该涂层有望用于修饰可生物降解的锌植入物。
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引用次数: 0
Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys 钴铬钼合金表面粗糙度及其对细胞粘附的调节作用
Q3 Engineering Pub Date : 2023-11-10 DOI: 10.1049/bsb2.12068
Satoshi Migita
Abstract Co‐Cr‐Mo ally (CCM) is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance. However, the influence of surface roughness on cell attachment and proliferation remains unclear. This study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of osteoblasts. CCM samples with different values of surface rouges were prepared by polishing. MC3T3‐E1 mouse osteoblasts were used for cell culture experiments. Cell attachment, morphology, and the expression of actin stress fibres, vinculin, and distribution of yes‐associated protein were analysed. Our results suggest that surface roughness does not significantly affect cell attachment and proliferation on CCM, unlike on titanium. Thus implies that other properties of CCM, such as physicochemical properties, may play a more substantial role in modulating cell behaviour. This study provides important insights into the design of CCM implants, suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.
Co - Cr - Mo ally (CCM)因其优异的机械性能和耐腐蚀性被广泛用于骨科和牙科种植体。然而,表面粗糙度对细胞附着和增殖的影响尚不清楚。本研究旨在阐明CCM表面粗糙度对成骨细胞附着和增殖的影响。采用抛光法制备了不同表面胭脂值的CCM样品。采用MC3T3‐E1小鼠成骨细胞进行细胞培养实验。分析细胞附着、形态、肌动蛋白应激纤维、血管蛋白的表达和yes相关蛋白的分布。我们的研究结果表明,与钛不同,表面粗糙度对CCM上细胞的附着和增殖没有显著影响。这意味着CCM的其他性质,如物理化学性质,可能在调节细胞行为中发挥更重要的作用。这项研究为CCM种植体的设计提供了重要的见解,表明除了调整表面粗糙度之外的方法可能需要改善生物相容性和骨整合。
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引用次数: 0
Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles 多酚介导的高稳定性和生物活性硒纳米颗粒的构建
Q3 Engineering Pub Date : 2023-10-19 DOI: 10.1049/bsb2.12067
Rong Hu, Xiao Wang, Lu Han, Xiong Lu
Abstract Selenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications. Selenium nanoparticles (SeNPs) exhibit low biological toxicity and high bioavailability; however, they are prone to aggregation and are extremely unstable, thereby diminishing their bioactivity and bioavailability. To overcome these limitations, ultra‐small, highly stable, and bioactive SeNPs were synthesised based on an in‐situ hybridisation strategy by using polyphenol‐grafted‐chitosan (GA‐CS) to control and restrict crystal growth of Se nanoparticles. The resultant GA‐CS@nSe exhibited an average particle size of ∼30 nm and was highly stable in aqueous solutions. In addition, GA‐CS@nSe displayed improved biocompatibility and enhanced antioxidative activity. Taken together, the authors provide a basis for polyphenol‐mediated construction of Se‐based particles with increased bioactivity.
硒(Se)是一种众所周知的人体健康必需元素,由于其抗氧化性质,在调节代谢中起着至关重要的作用。然而,有机硒化合物是有毒的,不能用于生物医学应用。硒纳米颗粒具有低生物毒性和高生物利用度的特点;然而,它们容易聚集,极不稳定,从而降低了它们的生物活性和生物利用度。为了克服这些限制,基于原位杂交策略,利用多酚接枝壳聚糖(GA - CS)来控制和限制硒纳米粒子的晶体生长,合成了超小、高度稳定和具有生物活性的SeNPs。合成的GA‐CS@nSe平均粒径为~ 30 nm,在水溶液中高度稳定。此外,GA‐CS@nSe显示出更好的生物相容性和增强的抗氧化活性。综上所述,作者为多酚介导构建具有更高生物活性的硒基颗粒提供了基础。
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引用次数: 0
Tribological characteristics of dimpled surfaces filled with dopamine‐modified MoS2 多巴胺修饰二硫化钼填充表面的摩擦学特性
Q3 Engineering Pub Date : 2023-10-17 DOI: 10.1049/bsb2.12066
Tuo Qin, Aibing Yu, Shuo Zhao, Kefan Li, Shaochun Qi, Jiawang Ye
Abstract To improve the tribological characteristics of dimples on the surface of 45 steel, the dimples were filled with MoS 2 and MoS 2 modified by dopamine (MoS 2 @ DA), and ball‐disk friction and wear tests were conducted. Specifically, the dimple filling gap, abrasion depth, and surface cross‐sectional area of 45 steel were measured. The wear morphology of the friction ball and exfoliation of MoS 2 in the dimples and the bending characteristics of the specimens were studied. The surface friction coefficient of MoS 2 @ DA‐filled specimen was 17.9% lower than MoS 2 ‐filled specimen, and the dimple filling gap was 70.1% lower, the surface abrasion depth was 5.8% lower, and the abrasion cross‐sectional area was 17.7% smaller. Moreover, the bending strength of the MoS 2 @ DA specimen was 3.27 times greater than that of the MoS 2 specimen, and the exfoliation of MoS 2 was slowed by filling with the MoS 2 @ DA. Finally, the tribological characteristics were also superior for the specimens prepared with MoS 2 @ DA.
摘要:为了改善45钢表面微窝的摩擦学特性,在微窝表面填充MoS 2和经多巴胺修饰的MoS 2 (MoS 2 @ DA),进行球盘摩擦磨损试验。具体地说,测量了45钢的韧窝填充间隙、磨损深度和表面截面积。研究了摩擦球的磨损形貌、凹窝中二氧化钼的剥落以及试样的弯曲特性。MoS 2 @ DA填充试样的表面摩擦系数比MoS 2填充试样小17.9%,凹窝填充间隙小70.1%,表面磨损深度小5.8%,磨损截面积小17.7%。此外,MoS 2 @ DA的抗弯强度是MoS 2的3.27倍,填充MoS 2 @ DA可以减缓MoS 2的剥落。最后,MoS 2 @ DA制备的试样的摩擦学性能也较好。
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引用次数: 0
Multifunctional hydrogels for chronic wounds repairing 多功能水凝胶用于慢性伤口修复
Q3 Engineering Pub Date : 2023-10-16 DOI: 10.1049/bsb2.12064
Xiao Wang, Rong Hu, Lu Han, Xiong Lu
Abstract Because of their tissue‐like mechanical performances, high biocompatibility, and adjustable functionality, hydrogels have become increasingly attractive materials for promoting wound healing. Chronic wounds include burn, diabetic, and infected wounds. Unlike common incision wounds, chronic wounds are more challenging to heal. To meet the clinical needs, multifunctional hydrogels should be fabricated and investigated. To guide future studies on the fabrication of hydrogel‐based chronic wound dressings, a review of advanced multifunctional hydrogels is necessary. Various hydrogels with advanced properties, such as antibacterial, antioxidant, bioadhesive, anti‐inflammatory, and wound healing properties, that can be used for skin burn wounds and diabetic wounds are summarised. Lastly, the prospects of advanced hydrogels for wound healing are elaborated.
由于其组织样机械性能、高生物相容性和可调节功能,水凝胶已成为促进伤口愈合的越来越有吸引力的材料。慢性伤口包括烧伤、糖尿病和感染伤口。与普通的切口伤口不同,慢性伤口的愈合更具挑战性。为了满足临床需要,多功能水凝胶的制备和研究势在必行。为了指导基于水凝胶的慢性伤口敷料的未来研究,有必要对先进的多功能水凝胶进行综述。总结了各种具有先进性能的水凝胶,如抗菌、抗氧化、生物粘接、抗炎和伤口愈合性能,可用于皮肤烧伤伤口和糖尿病伤口。最后,对新型水凝胶在伤口愈合中的应用前景进行了展望。
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引用次数: 0
A polyphenol‐induced hydroxyapatite coating modulates corrosion resistance and biocompatibility of magnesium alloys 多酚诱导羟基磷灰石涂层调节镁合金的耐腐蚀性和生物相容性
Q3 Engineering Pub Date : 2023-10-09 DOI: 10.1049/bsb2.12065
Tao Chai, Hao Zhang, Xiaolong Shen, Haibo Wang, Xingping Fan, Binbin Wang, Dingying He, Jia Su
Abstract In order to solve the problem of excessive degradation rate and insufficient biocompatibility of magnesium‐based bone implants, a polyphenol (EGCG) induced hydroxyapatite (HA) coating was prepared on the surface of AZ31 alloy. The physical and chemical properties and corrosion resistance of the coating were analysed in depth, and its biocompatibility was preliminarily explored in vitro. The results showed that the polyphenol (EGCG) conversion coating constructed on the AZ31 could successfully induce the formation of HA by complexing the phenolic hydroxyl group with calcium ions. The electrochemical and long‐term immersion experiments showed that the corrosion resistance of EGCG/HA composite coating was significantly improved. The self‐corrosion current density, hydrogen evolution and the increase of pH value of AZ31‐EGCG/HA were significantly lower than those of AZ31. On the basis of inhibiting the excessive corrosion of the substrate, the composite coating significantly improves the compatibility of pre‐osteoblasts, supports the adhesion and spreading and effectively reduces the haemolysis rate to less than 5%. The preparation method of the coating is simple, low cost and suitable for complex shape surfaces, which can significantly improve the corrosion resistance and biocompatibility of the AZ31 substrate. It is expected to provide a solution for the surface modification of magnesium‐based bone implants.
摘要:为了解决镁基骨植入物降解速度过快和生物相容性不足的问题,在AZ31合金表面制备了多酚(EGCG)诱导羟基磷灰石(HA)涂层。深入分析了涂层的理化性能和耐蚀性,并初步探讨了其体外生物相容性。结果表明,在AZ31上构建的多酚(EGCG)转化膜可以通过酚羟基与钙离子的络合,成功诱导HA的形成。电化学实验和长期浸渍实验表明,EGCG/HA复合涂层的耐腐蚀性能明显提高。AZ31 - EGCG/HA的自腐蚀电流密度、析氢量和pH值的升高均显著低于AZ31。复合涂层在抑制基体过度腐蚀的基础上,显著提高了成骨前细胞的相容性,支持成骨前细胞的粘附和扩散,有效降低溶血率至5%以下。该涂层制备方法简单,成本低,适用于复杂形状表面,可显著提高AZ31基材的耐腐蚀性和生物相容性。为镁基骨植入物的表面改性提供了一种解决方案。
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引用次数: 0
Bio-inspired low wear and durable lubrication interfacial system based on thixotropic hydrogel for artificial joints 基于触变性水凝胶的仿生低磨损耐用润滑界面系统
Q3 Engineering Pub Date : 2023-09-07 DOI: 10.1049/bsb2.12063
Bin He, Chen Wang, Xiong Xiong, Jun Li, Zhongmin Jin, Shuxin Qu

Inspired by the excellent wear resistance and lubrication of articular joints, a novel bionic interfacial system was proposed by combining thixotropic hydrogel with surface porous Ultrahigh Molecular Weight Polyethylene (UHMWPE). Thixotropic hydrogel, synthesised by gelatin, alginate sodium, tannic acid and weak crosslinking by Ca2+ (Gel-TA-Alg@Ca2+), was used as a lubricant due to its shear-thinning when loaded, then the recovery viscosity to be benefitted for reserving in surface pores on UHMWPE when unloaded. Surface porous UHMWPE was fabricated by using hydroxyapatite particles as porogen to control its porosity, pore size, surface roughness and surface energy (PE-HA). Gel-TA-Alg@Ca2+ significantly reduced average coefficients of friction and wear factors compared to those under normal saline and calf serum solution lubricating after reciprocating tribological testing. Notably, Gel-TA-Alg@Ca2+ still maintained thixotropy and was stored in surface pores of UHMWPE even after tribological testing for 7200 min. Thus, durable lubrication could be realised due to the synergistic effect of surface porous structure and thixotropy. Stribeck curves showed the characterisations of mixed, elastohydrodynamic and hydrodynamic, but without boundary lubrications for PE-30HA under three lubricants. The present results might provide the potential application to construct the durable lubrication bionic articular joint interfacial system for artificial joints.

受关节关节良好耐磨性和润滑性的启发,将触变水凝胶与表面多孔超高分子量聚乙烯(UHMWPE)相结合,提出了一种新型的仿生界面体系。触变水凝胶,由明胶、海藻酸钠、单宁酸和Ca2+弱交联合成(Gel‐TA‐Alg@Ca2+),由于其在加载时的剪切变薄而被用作润滑剂,然后在卸载时,回收粘度有利于保留在UHMWPE的表面孔隙中。以羟基磷灰石颗粒为成孔剂,控制其孔隙率、孔径、表面粗糙度和表面能(PE‐HA),制备了表面多孔UHMWPE。凝胶-TA-Alg@Ca2+往复摩擦学试验后,与生理盐水和小牛血清溶液润滑相比,平均摩擦系数和磨损因子显著降低。值得注意的是,Gel‐TA‐Alg@Ca2+仍然保持触变性,并且即使在摩擦学测试7200分钟后仍储存在UHMWPE的表面孔隙中。因此,由于表面多孔结构和触变性的协同作用,可以实现持久润滑。Stribeck曲线显示了PE‐30HA在三种润滑剂下的混合、弹流动力学和流体动力学特征,但没有边界润滑。本研究结果可能为构建人工关节耐用润滑仿生关节界面系统提供潜在的应用前景。
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引用次数: 0
The influence of lubricant temperature on the wear of total knee replacements 润滑油温度对全膝关节置换术磨损的影响
Q3 Engineering Pub Date : 2023-09-06 DOI: 10.1049/bsb2.12061
Raelene M. Cowie, Adam Briscoe, Louise M. Jennings

Experimental in vitro simulation can be used to predict the wear performance of total knee replacements. The in vitro simulation should aim to replicate the in vivo loading, motion and environment experienced by the joint, predicting wear and potential failure whilst minimising test artefacts. Experimental wear simulation can be sensitive to environmental conditions; the environment temperature is one variable which should be controlled and was the focus of this investigation. In this study, the wear of an all-polymer (PEEK-OPTIMA™ polymer-on-UHMWPE) total knee replacement and a conventional cobalt chrome-on-UHMWPE implant of similar initial surface topography and geometry were investigated under elevated temperature conditions. The wear was compared to a previous study of the same implants under simulator running temperature (i.e. without heating the test environment). Under elevated temperature conditions, the wear rate of the UHMWPE tibial inserts was low against both femoral component materials (mean <2 mm3/million cycles) and significantly lower (p < 0.05) than for investigations at simulator running temperature. Protein precipitation from the lubricant onto the component articulating surfaces is a possible explanation for the lower wear. This study highlights the need to understand the influence of different variables including environmental temperature to minimise the test artefacts during wear simulation which may affect the wear rates.

体外实验模拟可用于预测全膝关节置换术的磨损性能。体外模拟应旨在复制关节所经历的体内负荷、运动和环境,预测磨损和潜在故障,同时最大限度地减少测试伪影。实验磨损模拟可能对环境条件敏感;环境温度是一个需要控制的变量,也是本研究的重点。在本研究中,全聚合物(PEEK‐OPTIMA™ 聚合物超高分子量聚乙烯)全膝关节置换术和具有相似初始表面形貌和几何形状的传统钴铬超高分子量聚合物植入物在高温条件下进行了研究。将磨损情况与之前在模拟器运行温度下(即在不加热测试环境的情况下)对相同植入物进行的研究进行了比较。在高温条件下,UHMWPE胫骨插入物对两种股骨组件材料的磨损率都较低(平均<2 mm3/million循环),并且显著低于(p<0.05)模拟器运行温度下的研究。从润滑剂到部件铰接表面上的蛋白质沉淀是较低磨损的可能解释。这项研究强调,需要了解包括环境温度在内的不同变量的影响,以最大限度地减少磨损模拟过程中可能影响磨损率的测试伪影。
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引用次数: 1
Morphology and gene expression of sex-determining region Y-box 9 and runt-related transcription factor 2 in centrifugally compressed cell collagen-combined constructs (C6) 离心压缩细胞-胶原联合构建体中性别决定区Y‐box 9和runt相关转录因子2的形态学和基因表达(C6)
Q3 Engineering Pub Date : 2023-09-02 DOI: 10.1049/bsb2.12062
Xu Ye, Masashi Yamazaki, Wataru Ando, Norimasa Nakamura, Hiromichi Fujie

The authors previously developed a scaffold-free tissue-engineered construct (TEC) from mesenchymal stem cells (MSCs). Although the TEC exhibited even cell distribution and was successfully applied for cartilage repair in animal models, it is unsuitable for relatively large-scale cartilage defects due to its small size. To solve the problem, the authors recently developed a novel biomaterial, a centrifugally compressed cell-collagen combined construct (C6) from a mixture of MSCs and atelocollagen, both of which are subjected to centrifugation. The results of the previous study indicated that C6 exhibited high cell viability (70 %) and sufficient cell distribution similar to that of the TEC. In the present study, the morphology and gene expression of C6 were investigated. Histological examination indicated that C6 is six times thicker (approximately 1 mm) than the TEC after a 7-day culture. The C6 remained unchanged in scale with increased cell density after a 21-day culture. Scanning electron microscopic observation indicated that C6 exhibited interconnected and porous microstructures, while the TEC had close-knit microstructures. Reverse transcriptase-polymerase chain reaction analysis indicated that the expression of sex-determining region Y-box 9 and runt-related transcription factor 2 was significantly higher in C6 than that in TEC.

作者之前从间充质干细胞(MSC)中开发了一种无支架的组织工程构建体(TEC)。尽管TEC表现出均匀的细胞分布,并在动物模型中成功应用于软骨修复,但由于其体积小,不适用于相对较大的软骨缺损。为了解决这个问题,作者最近开发了一种新的生物材料,一种离心压缩的细胞-胶原组合构建体(C6),由MSCs和去端胶原的混合物制成,两者都经过离心。先前研究的结果表明,C6表现出高细胞活力(70%)和足够的细胞分布,与TEC相似。本研究对C6的形态和基因表达进行了研究。组织学检查表明,经过7天的培养,C6比TEC厚6倍(约1毫米)。C6在培养21天后保持不变,细胞密度增加。扫描电子显微镜观察表明,C6表现出互连和多孔的微观结构,而TEC具有紧密结合的微观结构。逆转录聚合酶链反应分析表明,C6中性别决定区Y‐box 9和runt相关转录因子2的表达显著高于TEC。
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引用次数: 0
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