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Studying the Genetic Parameters of Some Cultivars of Faba Bean (Vicia faba L.) and Evaluating Their Performance under Different Levels of Phosphorous 不同磷水平下蚕豆品种遗传参数研究及性能评价
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.03.78
Ali H. Algraishi, Faez F. Alogaidi
A field experiment was carried out during the winter season of 2021-2022 in the research station - College of Agricultural Engineering Sciences - University of Baghdad in order to study the genetic parameters of some cultivars of faba bean cultivars and evaluate their performance under different levels of phosphorus. Spilled plots were arranged according to randomized complete block design (RCBD) at three replications. The main plots included three levels of phosphorous fertilizer (80, 120 and 160 Kg ha-1 ) and the control treatment (without fertilizer). In contrast, the subplots included four faba bean cultivars (Local, Spanish, Dutch and New Zealand). The results showed highly significant effects of phosphorous fertilizer levels on the most studied traits, as adding phosphorous fertilizer at 160 Kg gave the highest means of several pods per plant (17.78 pods plant-1 ) and seed yield (4.403 tons ha-1 ). Also, the results showed that the faba bean cultivars were significantly different in most studied traits, as the Local cultivar achieved the highest mean number of pods per plant (16.95pod plant-1 ). In contrast, the Dutch cultivar achieved the highest mean number of seeds per pod (5.78 seed pod-1 ), whereas the Spanish cultivar achieved the highest mean weight of 100 seeds (86.95 g) and seed yield (5.295 ton ha-1 ). The interaction between studied factors had a non-significant effect on all studied traits except the number of pods per plant. The genetic variance recorded greater values than the environmental variance in most of the studied traits, indicating that the genetic variance significantly contributed to the phenotypic variance. Keywords: Genetic indicators, phosphorous, Vicia faba L., G.C.V., PCV.
为了研究部分蚕豆品种的遗传参数,并评价其在不同磷水平下的表现,于2021-2022冬季在巴格达大学农业工程科学学院研究站进行了田间试验。溢出区按随机完全区设计(RCBD)排列,每3个重复。主要样地包括3个水平磷肥(80、120和160 Kg hm -1)和对照处理(不施肥)。相比之下,子小区包括4个蚕豆品种(本地、西班牙、荷兰和新西兰)。结果表明,施磷水平对研究性状的影响非常显著,施磷水平为160 Kg时,单株荚果数最高(17.78个),籽粒产量最高(4.403 t ha-1)。结果表明,不同品种蚕豆在多数性状上存在显著差异,其中本地品种单株平均荚果数最高(16.95荚果-1)。相比之下,荷兰品种的平均每荚种子数最高(5.78粒每荚-1),而西班牙品种的平均每荚种子重最高(86.95克),种子产量最高(5.295吨每荚-1)。除单株荚果数外,各因子间的交互作用对其他性状均无显著影响。多数性状的遗传变异值大于环境变异值,表明遗传变异对表型变异有显著贡献。关键词:遗传指标,磷,蚕豆,gcv, PCV
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引用次数: 0
The expression miRNA-195 in a sample of Iraqi breast cancer patients. miRNA-195在伊拉克乳腺癌患者样本中的表达。
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.03.87
Ahmed Nasser Ibraheem AL-saqabi, Ismail Hussein Aziz
Breast carcinoma is the most prevalent cancer-related cause of death in women, and metastasis is the main factor in morbidity. The total number of new cases of cancer in Iraq during the year 2019 was 35,864. New non-invasive prognostic biomarkers are needed for the rapid recognition and differentiation between breast cancer (BC) stages for treatment choice improvement. MicroRNA (miRNA) are small, noncoding RNAs regulating gene expression and involve many cellular processes, including metastasis. Circulating miRNAs (detected in the blood) show considerable potential as biomarkers for helping diagnosis or tracking treatment efficacy. Materials and Methods: total RNA was extracted from serum from (n=50) patients and (n=26) healthy control to measure the MicroRNA 195 expression using SYBR green-based real-time RT-PCR technology. As a result, the expression levels miR-195 in breast cancer patients’ serum were significantly increased (up-regulated) compared to those in the normal adjacent serum. BC group showed a higher significant miR-195 expression (upregulation) when compared with those in the control group. While the highest expression of miR195 was recorded in stage II. Keywords: Breast Cancer, MicroRNA, miR-195, Stage, Iraq
乳腺癌是妇女中最常见的癌症相关死亡原因,而转移是发病率的主要因素。2019年,伊拉克新发癌症病例总数为35864例。需要新的非侵入性预后生物标志物来快速识别和区分乳腺癌(BC)分期,以改善治疗选择。MicroRNA (miRNA)是调节基因表达的小非编码rna,参与许多细胞过程,包括转移。循环mirna(在血液中检测到)作为帮助诊断或跟踪治疗效果的生物标志物显示出相当大的潜力。材料与方法:分别从50例患者和26例健康对照血清中提取总RNA,采用基于SYBR绿色的实时RT-PCR技术检测MicroRNA 195的表达。因此,乳腺癌患者血清中miR-195的表达水平较正常邻近血清中miR-195的表达水平显著升高(上调)。与对照组相比,BC组miR-195表达显著升高(上调)。而miR195在II期表达量最高。关键词:乳腺癌,MicroRNA, miR-195,分期,伊拉克
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引用次数: 0
FSCN1 Gene Expression Influence on Breast Cancer in Iraqi Patients FSCN1基因表达对伊拉克乳腺癌患者的影响
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.03.85
Rifaat M. Rifaat, Mohammed I. Nader
Our investigation aim was to ascertain how the Fascin actin-bundling protein 1 (FSCN1) gene affected breast cancer patients and how it affected the molecular type of the disease (Luminal A, Luminal B, Triple negative, Enrich Her2).By collecting blood samples from sixty patients with Breast cancer from many hospitals in Baghdad/Iraq between the periods (October 2021 to August 2022) and collecting forty volunteers heaths as Control. The volunteer's blood samples were collected and tested with Cancer antigen 15-3 (CA 15-3) to confirm absent breast cancer. The blood and control samples from these patients were collected, the RNA was extracted, and molecular methods using PCR and primers targeting the FSCN1 gene were used. The results showed that genes found in all patient samples have overexpression compared to healthy volunteers, and we also discovered differences in expression between the molecular types of breast cancer. We discovered that Triple-negative breast cancer is more affected than Luminal A, B, and Enrich Her2. Keywords: Breast Cancer, Molecular classification breast cancer, Fascin Actin Bundling protein 1 genes
我们的研究目的是确定FSCN1基因如何影响乳腺癌患者,以及它如何影响疾病的分子类型(Luminal A, Luminal B, Triple negative, Enrich Her2)。通过在2021年10月至2022年8月期间从巴格达/伊拉克的多家医院收集60名乳腺癌患者的血液样本,并收集40名志愿者作为对照。研究人员采集了志愿者的血液样本,并对其进行了癌症抗原15-3 (CA 15-3)检测,以确定是否存在乳腺癌。采集患者的血液和对照样本,提取RNA,采用PCR和引物靶向FSCN1基因的分子方法。结果显示,与健康志愿者相比,所有患者样本中发现的基因都有过表达,我们还发现了乳腺癌分子类型之间表达的差异。我们发现三阴性乳腺癌比Luminal A, B和Enrich Her2更受影响。关键词:乳腺癌,分子分类,束状蛋白,肌动蛋白捆绑蛋白1基因
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引用次数: 0
Autophagy induction using Resveratrol enhances the anti-cancer efficacy of Doxazosin in breast cancer cells. 白藜芦醇诱导自噬可增强多沙唑嗪对乳腺癌细胞的抗癌作用。
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.04.88
Ali Sami Ahmed Alhayali, Waseem Ali Hasan, Firas Subhi Salah
The combination of anti-cancer drugs improves effectiveness compared to the mono-therapy scenario by targeting key pathways synergistically or in an additive way. Doxazosin (DOX) and Resveratrol (RES) are reported to have an anti-cancer impact against different cancer cells. Aim: To evaluate the anti-cancer properties of Doxazosin and Resveratrol, each alone or in combination, in inhibiting breast cancer cell proliferation. Methods: MCF-7 cancer cells were seeded to a confluent monolayer and treated with 100, 50, 25, 12.5, 6.25, and 3.12 µM of each drug alone and as a combination. Cytotoxicity was evaluated using dimethyl thiazolyl diphenyl tetrazolium salt (MTT) assay and colony formation assay. The immunocytochemistry technique was conducted to evaluate caspase-3 and GABARAP expression. Results: All the drugs have a significant effect on cancer cell proliferation. The combination treatment of Doxazosin-Resveratrol has a more cytotoxic effect than each drug alone, as well as in colony formation of MCF-7 cancer cells. In combination treatment, caspase-3 had a higher expression pattern than other treatments. Resveratrol treatment elevated GABARAP expression in cancer cells, indicating the induction of the autophagy process. Conclusion: Although each drug has its characteristic result of a cytotoxic effect, the combination of Doxazosin and Resveratrol synergizes the inhibition of MCF-7 cancer cell proliferation. Keywords: Resveratrol; Doxazosin; combination; MCF-7; Autophagy.
与单一治疗方案相比,联合抗癌药物通过协同或加性方式靶向关键途径提高了疗效。据报道,Doxazosin (DOX)和Resveratrol (RES)对不同的癌细胞具有抗癌作用。目的:评价多沙唑嗪和白藜芦醇单用或联用对乳腺癌细胞增殖的抑制作用。方法:将MCF-7癌细胞接种于混合单层细胞,分别用100、50、25、12.5、6.25、3.12µM的药物单独或联合处理。采用二甲基噻唑基二苯四唑盐(MTT)法和菌落形成法评价细胞毒性。采用免疫细胞化学技术检测caspase-3和GABARAP的表达。结果:所有药物对肿瘤细胞增殖均有显著影响。Doxazosin-Resveratrol联合治疗比单独使用每种药物具有更强的细胞毒性作用,以及MCF-7癌细胞的集落形成。联合治疗时,caspase-3的表达模式高于其他治疗。白藜芦醇处理可提高GABARAP在癌细胞中的表达,表明诱导了自噬过程。结论:虽然每种药物都有其独特的细胞毒性作用,但Doxazosin和白藜芦醇合用可协同抑制MCF-7癌细胞增殖。关键词:白藜芦醇;Doxazosin;结合;MCF-7;自噬。
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引用次数: 1
Synthesis, Characterization and Evaluation of the Biological Activity of Some New Thiazolidine Derivatives Derived from Schiff bases 席夫碱衍生噻唑烷类化合物的合成、表征及生物活性评价
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.03.20
Hussam Z. Naji, Eman M. Hussain
In this research, new compounds were synthesized via the reaction of dichloroacetic acid with two moles of piperidine. The novel acid 1 was converted to its ester 2. Acid hydrizide 3 was prepared by the reaction of hydrazine hydrate with new ester 2, which was later used to prepare derivatives of Schiff bases 4-13. In the last step, Schiff bases and thioglycolic acid were reacted to give thiazolidine derivatives 14-23. All these compounds were diagnosed using melting points, FTIR, 1HNMR and mass spectroscopy. Scheme 1 shows all the synthesized compounds' reaction steps and structures. Keywords: Thiazolidine; Schiff bases; biological activity; piperidine; dichloroacetic acid.
本研究通过二氯乙酸与2摩尔哌替啶的反应合成了新的化合物。这种新型酸被转化成它的酯。由水合肼与新酯2反应制备酸肼3,并将其用于制备希夫碱4-13衍生物。最后一步,席夫碱与巯基乙酸反应生成噻唑烷衍生物14-23。所有化合物都通过熔点、FTIR、1HNMR和质谱进行了诊断。图1显示了所有合成化合物的反应步骤和结构。关键词:Thiazolidine;希夫碱;生物活性;哌啶;二氯乙酸。
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引用次数: 0
A comparison with micro albuminuria indicates whether urine and serum kidney injury molecule-1 can predict the onset of early diabetic nephropathy (DN). 通过与微量蛋白尿的比较,探讨尿和血清肾损伤分子-1是否可以预测早期糖尿病肾病(DN)的发生。
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.03.46
Dalia M. Saleh, Manal K Rasheed, Nabeel K. Alwandi
Diabetic nephropathy (DN) is the most frequent consequence of DM and a significant contributor to chronic kidney disease, a multifactorial illness. Kidney injury molecule-1 (KIM-1) is a sensitive and accurate indicator of kidney damage and a predictive indicator. Aim: The present investigation aimed to examine serum and urine KIM-1 as a DN early marker. Patients and methods: The present study included 150 participants, among whom 50 non-diabetic participants were chosen as controls. One hundred diabetic participants were split into two groups based on their urine albumin/creatinine ratio (ACR) as participants with normoalbuminuria (T2DM patients without nephropathy) and microalbuminuria (T2DM patients with nephropathy). The blood glucose, HbA1c, s.urea, and creatinine levels in serum and urine were measured using standard laboratory techniques, and Elisa Essay measured serum and urine KIM-1 levels. Results: There was a distinct variation in the mean serum and urine KIM-1 between the control and diabetics without microalbuminuria (P = 0.001). Serum KIM-1 correlated with ACR (P = 0.669) in people with diabetes with microalbuminuria. Urine KIM-1 was less correlated than serum KIM-1 (p = 0.257). A strong association was found between ACR and serum KIM1 in people with diabetes with microalbuminuria and a low correlation between ACR and urine KIM-1 in people with diabetes with microalbumin. Conclusion: According to the current investigation, diabetic groups with microalbuminuria had higher serum and urine levels of KIM-1 than the control groups. Additionally, there was a favorable correlation between serum KIM-1 and the length of diabetes. More extensive multicentric trials are also needed to assess the efficacy of serum and urine KIM-1 as a DN early marker. Keywords: Serum /Urine KIM-1; Dibetic nephropathy; Microalbumin; DM type2
糖尿病肾病(DN)是糖尿病最常见的后果,也是慢性肾脏疾病的重要因素,是一种多因素疾病。肾损伤分子-1 (KIM-1)是一种灵敏、准确的肾损伤指标和预测指标。目的:本研究旨在检测血清和尿液KIM-1作为DN的早期标志物。患者和方法:本研究包括150名参与者,其中50名非糖尿病患者作为对照。100名糖尿病患者根据尿白蛋白/肌酐比值(ACR)分为正常蛋白尿(无肾病的T2DM患者)和微量蛋白尿(有肾病的T2DM患者)两组。采用标准实验室技术测定血清和尿液中的血糖、糖化血红蛋白、尿素和肌酐水平,Elisa法测定血清和尿液中的KIM-1水平。结果:无微量白蛋白尿的糖尿病患者与对照组的平均血清和尿液KIM-1有明显差异(P = 0.001)。糖尿病合并微量白蛋白尿患者血清KIM-1与ACR相关(P = 0.669)。尿KIM-1与血清KIM-1相关性较低(p = 0.257)。糖尿病伴微量白蛋白尿患者的ACR和血清KIM1之间存在很强的相关性,而糖尿病伴微量白蛋白尿患者的ACR和尿KIM-1之间存在较低的相关性。结论:根据目前的调查,糖尿病伴微量白蛋白尿组血清和尿液中KIM-1水平高于对照组。此外,血清KIM-1与糖尿病病程之间存在良好的相关性。还需要更广泛的多中心试验来评估血清和尿液KIM-1作为DN早期标志物的有效性。关键词:血清/尿KIM-1;Dibetic肾病;微白蛋白;DM type2
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引用次数: 1
Response of Local Garlic to Potassium and Sulfur Fertilization Method 地方大蒜对钾硫施肥方式的响应
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.04.11
Raed K. A. Al-Mohammadi, Maath M. M. Al-Abdaly
A field experiment was conducted at the Agricultural Research Station of the College of Agriculture, University of Anbar, for the agricultural season 2021- 2022. This experiment aimed to study the effect of potassium and sulfur application on local garlic's growth, yield, and quality. The experiment included four levels of potassium soil fertilization (0, 200, 250, and 300 kg.ha-1 ), three levels of foliar spraying of potassium (0, 5, and 10 g.L-1 ), and three levels of soil fertilization of sulfur (0, 40, and 50 kg.ha-1 ). The study used the randomized complete block design (RCBD) in combinations. The results showed significant differences in the characteristics of vegetative growth, yield characteristics, and qualitative characteristics. The combination (300 kg K2O.ha-1 +10 g.L-1 + 50 kg S.ha-1 ) significantly exceeded by giving the highest leaves number, leaves area and shoot dry weight, which amounted to 11.42 leaf.plant-1 and 795.00 cm2 .plant-1 and 10.87 g.plant-1 , respectively. In comparison, the control treatment gave (8.80 leaves.plant-1 and 571.00 cm2 .plant-1 and 8.17 g.plant-1 ), for the same above traits, respectively. The same combination achieved a significant increase in yield traits (cloves number, clove weight, yield/plant, and total yield) with 37.58 cloves, 2.71 g, 102.03 g, and 51.01 t.ha-1 , respectively, compared to the control treatment, which gave (32.00 cloves, 1.81 g, 58.17 g, and 29.08 t.ha-1 ). The same treatment led to an increase in the percentage of potassium and sulfur in the bulbs, which recorded the highest percentage of 1.67% and 0.60%, respectively, compared to the control treatment, which recorded the lowest percentage of 1.36% and 0.40%, respectively. Keywords: Garlic, Fertilization, Potassium, Sulfur, Growth, Yield.
在安巴尔大学农学院农业研究站进行了2021- 2022农业季节的田间试验。本试验旨在研究钾肥和硫肥对地方大蒜生长、产量和品质的影响。试验分0、200、250、300 kg 4个施肥水平。Ha-1),三个水平的叶面喷钾(0、5和10 g)。L-1),以及三个水平的土壤硫施肥(0、40和50 kg)。农业)。该研究采用随机完全区组设计(RCBD)进行组合。结果表明,在营养生长特征、产量特征和质量特征上存在显著差异。组合(300 kg K2O)。Ha-1 + 10g。L-1 + 50 kg S.ha-1)的叶片数、叶面积和地上部干重均达到最高,达到11.42片。Plant-1、Plant-1、Plant-1分别为795.00 cm2和10.87 gm2。对照处理的叶片数量为8.80片。植株-1和8.17 g.plant-1分别为571.00 cm2和8.17 g.plant-1。与对照处理(32.00瓣、1.81 g、58.17 g和29.08 t.ha-1)相比,同一组合处理的产量性状(丁香数、丁香重、单株产量和总产量)分别为37.58瓣、2.71 g、102.03 g和51.01 t.ha-1)显著提高。同样处理导致鳞茎中钾和硫的百分比分别增加了1.67%和0.60%,而对照处理的百分比最低,分别为1.36%和0.40%。关键词:大蒜,施肥,钾,硫,生长,产量
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引用次数: 1
Effect of Adding Levels of Palm Fronds Compost and Mineral Fertilizer on Fertile Soil Characteristics, Quality, and Productivity of Maize Yield (Zea Mays L.) 棕榈叶堆肥和矿质肥添加水平对玉米肥力土壤特性、品质及产量的影响
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.03.29
Abeer Mounir Abdel Hadi, Bushra Mahmoud Alwan
An experiment was carried out in one of the fields of the Soil Research Department - Agricultural Research Department/Ministry of Agriculture in the Abu Ghraib district at latitude 33° 17" 31 N and longitude 44° 03" 56 E and 35 m above sea level. This field study was conducted in the autumn season 2021-2022 for the cultivation of yellow maize ( Maha cultivar) in sedimentary soil with silty clay loam texture, with a Split Plot Design. The treatments were distributed using the RCBD for three replicates with two factors. The first factor represents the main plots that include the addition of mineral fertilizer 120, 80, and 320 kg.ha-1 for each of (N, P, and K), respectively, at three levels (0, 50, and 100%) of the fertilizer recommendation. On the other hand, the second factor was a subplot of organic fertilizer (palm frond compost) at three levels (0, 5, and 10) μg.ha-1 . Soil samples were taken to estimate the availability of nitrogen, phosphorous, and potassium, where the total yield and percentage of protein for yellow maize were estimated. The results showed that adding organic fertilizers (palm fronds) with the levels of mineral fertilizers increased the availability of nutrients and the yield of maize. Accordingly, the treatment O2M2 achieved the highest values of nutrient availability, quantity, and quality of yield, reaching (59.167, 33.407, and 257.967) mg.kg-1 soil and (10,096) μg.ha-1 and (9.435%) for each of nitrogen, phosphorous, potassium, yield, and protein percentage, respectively. Moreover, there were no significant differences between the treatments of O1M2 and O2M1 in the amount of yield and the percentage of protein, which gave the values of 8.403 and 8.134 μg.ha-1, respectively, and the protein percentage of 8.630 and 8.915% respectively. It can be concluded that organic fertilizers can be added to compensate for mineral fertilizers, reduce environmental pollution, and reduce the economic cost and soil preservation because organic fertilizers are considered safe and environmentally friendly. Keywords: yellow maize, mineral fertilizer, palm fronds compost.
试验是在阿布格莱布地区土壤研究部-农业研究部/农业部的一块田里进行的,该地区北纬33°17" 31 ",东经44°03" 56,海拔35米。本研究于2021-2022年秋季在粉质粘壤土质沉积土中采用裂地设计进行黄玉米(Maha品种)的田间试验。采用RCBD进行处理,每组3个重复,每组2个因子。第一个因子表示主要地块,包括添加120、80和320 kg的矿肥。在3个施肥推荐水平(0、50和100%)下,(N、P和K)各为ha-1。另一方面,第二个因素是有机肥料(棕榈叶堆肥)在3个水平(0、5和10)μg的子小区。农业的。采用土壤样品估算氮、磷和钾的有效性,估算黄玉米的总产量和蛋白质百分比。结果表明,有机肥(棕榈叶)与矿质肥配合施用可提高玉米的养分利用率和产量。因此,O2M2处理在养分有效性、产量数量和质量上均达到最高,分别为59.167、33.407和257.967 mg。Kg-1土壤和(10096)μg。氮、磷、钾、产量和蛋白质百分比的Ha-1分别为9.435%和9.435%。此外,O1M2和O2M1处理在产量和蛋白质含量上无显著差异,分别为8.403和8.134 μg。Ha-1,蛋白质含量分别为8.630和8.915%。综上所述,由于有机肥被认为是安全和环保的,因此可以添加有机肥来补偿矿质肥,减少环境污染,降低经济成本和土壤保持性。关键词:黄玉米,矿物肥,棕榈叶堆肥。
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引用次数: 1
Minimizing the side effects of Doxorubicin Induced Hepatotoxicity by using alcoholic extract of Date Palm in adult rats 用枣椰树酒精提取物对成年大鼠减少阿霉素肝毒性的副作用
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.04.86
Najwa Imad Sulaiman Saleh, Siham Agmee Wadee, Entedhar R. Sarhat
Doxorubicin (DOX) is a highly effective drug for chemotherapy. However, hepatotoxicity reduces its clinical utility in humans. Thus, this study was designed to examine Date Palm extract on serum anti-inflammatory markers (interleukin(IL) IL-1B, IL-6 and IL-10). Forty adult rats were divided into 4 groups (G1 control, G2 receiving 2mgkg of DPE orally, G3 treated with 2mgkg of DOX IP, and G4 received 2mgkg of DOX via IP and 2mgkg of DPE by oral gavage daily for 30 days). At the end of the study, animals were sacrificed, and livers were analyzed histologically. The Dox group showed significantly higher levels of serum IL-1B, IL-6, and IL-10 than the control group, with inflammation and necrosis in hepatic histopathology. In the DPE+ DOX group, it was detected that DOX treatment caused a significant decrease in serum IL-1B, IL-6, and IL-10 levels. Collectively, pre-coadministration of DPE partially mitigated DOX-induced hepatic injuries via its antioxidant, anti-inflammatory, anti-fibrotic, and antiapoptotic protein.
阿霉素(DOX)是一种非常有效的化疗药物。然而,肝毒性降低了其在人类中的临床应用。因此,本研究旨在检测枣椰树提取物对血清抗炎标志物(白细胞介素(IL) IL- 1b、IL-6和IL-10)的影响。将40只成年大鼠分为4组(G1对照组,G2组口服DPE 2mgkg, G3组口服DOX IP 2mgkg, G4组每日口服DOX IP 2mgkg和DPE 2mgkg,连续30 d)。研究结束时,处死动物,对肝脏进行组织学分析。Dox组大鼠血清IL-1B、IL-6、IL-10水平明显高于对照组,肝脏组织病理表现为炎症、坏死。在DPE+ DOX组中,检测到DOX治疗导致血清IL-1B、IL-6和IL-10水平显著降低。总的来说,预共给药DPE通过其抗氧化、抗炎、抗纤维化和抗凋亡蛋白部分减轻了dox诱导的肝损伤。
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引用次数: 1
Estimation of Some Biochemical Tests in the Serum of Obese Men with Normal Blood Pressure and High Blood Pressure 正常血压和高血压肥胖男性血清生化指标的评价
Q4 Medicine Pub Date : 2023-10-15 DOI: 10.21931/rb/css/2023.08.04.25
Shaimaa Khalid Moufak, Rowshen Hani Al Nakeeb, Tamara Sami Naji
Obesity is a medical word that refers to a state in which a person's body fat levels are excessively high. Obesity is linked to a variety of health issues in humans, like the emergence of hypertension. This study aimed to look at the blood glucose concentration, urea, creatinine, and lipid profile factors in obese and hypertension-overweight men's sera. The study included 75 people who were evenly divided into three groups: healthy controls, normotensive obese people, and hypertension-obese people. When comparing obese males to controls, there was a significant increase (P<0.01) in blood glucose, urea, creatinine, cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) although only triglycerides (TGs) and VLDL-C were substantially different in hypertension obese versus normotensive obese. Compared to controls, Obese men had significantly lower levels of high-density lipoprotein cholesterol (HDL-C). High levels of triglycerides (TGs) and Very Low-density Lipoprotein cholesterol (VLDL) in hypertensive obese males show they play a role in hypertension problems. Keywords: Obesity, Hypertension, Urea, Creatinine, lipid profile.
肥胖是一个医学词汇,指的是一个人体内脂肪水平过高的状态。肥胖与人类的多种健康问题有关,比如高血压的出现。本研究旨在观察肥胖和高血压超重男性血清中的血糖浓度、尿素、肌酐和脂质谱因素。这项研究包括75人,他们被平均分为三组:健康对照组、正常肥胖者和高血压肥胖者。当将肥胖男性与对照组进行比较时,血糖、尿素、肌酐、胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)和极低密度脂蛋白胆固醇(VLDL-C)显著增加(P<0.01),尽管高血压肥胖与正常肥胖之间只有甘油三酯(TGs)和VLDL-C存在显著差异。与对照组相比,肥胖男性的高密度脂蛋白胆固醇(HDL-C)水平显著降低。高血压肥胖男性中高水平的甘油三酯(tg)和极低密度脂蛋白胆固醇(VLDL)表明它们在高血压问题中起作用。关键词:肥胖,高血压,尿素,肌酐,血脂。
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引用次数: 1
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Revista Bionatura
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