Background and Objective: The role of biofilm formation by bacteria has been considered as an important stage in the pathogenesis of Klebsiella pneumoniae. This pathogen is one of the most important opportunistic pathogen agents of nosocomial infections, such as pneumonia, urinary tract infections, invasive infections, and surgical site infections. This study aimed to investigate the biofilm producer strains among different clinical isolates of Klebsiella pneumoniae. Materials and Methods: This observational study was conducted on 230 clinical samples with bacterial infection. The selective culture media and biochemical tests were used for the identification of Klebsiella pneumoniae isolates. Crystal Violet assay and PCR were also used to characterize biofilm strains. Results: Out of 230 samples collected from different specimens, 100 isolates (43.47%) of Klebsiella pneumoniae were identified by biochemical tests. Of these, 58 (58%) and 42 isolates (42%) were isolated from the male and female individuals, respectively. The phenotypic method showed 2, 27, 41, and 30 isolates as strong biofilm producers, medium biofilm producers, weak biofilm producers, and non-biofilm producers, respectively. The frequency of genes were reported as wzm (47%), markA (69%), pgaAa (65%), and wbbm (47%), respectively. Conclusion: The markA gene plays an important role in biofilm formation and can identify different biofilms in Klebsiella pneumoniae strains. It is also possible to identify bacteria with weak, moderate, and strong biofilms.
{"title":"Investigation of the Relationship between Antibiotic Resistance and Biofilm Production in Klebsiella pneumoniae Isolated from Hamadan Hospitals, Iran","authors":"M. Bayati, R. Habibipour, B. Asghari","doi":"10.21859/AJCM.26.1.51","DOIUrl":"https://doi.org/10.21859/AJCM.26.1.51","url":null,"abstract":"Background and Objective: The role of biofilm formation by bacteria has been considered as an important stage in the pathogenesis of Klebsiella pneumoniae. This pathogen is one of the most important opportunistic pathogen agents of nosocomial infections, such as pneumonia, urinary tract infections, invasive infections, and surgical site infections. This study aimed to investigate the biofilm producer strains among different clinical isolates of Klebsiella pneumoniae. Materials and Methods: This observational study was conducted on 230 clinical samples with bacterial infection. The selective culture media and biochemical tests were used for the identification of Klebsiella pneumoniae isolates. Crystal Violet assay and PCR were also used to characterize biofilm strains. Results: Out of 230 samples collected from different specimens, 100 isolates (43.47%) of Klebsiella pneumoniae were identified by biochemical tests. Of these, 58 (58%) and 42 isolates (42%) were isolated from the male and female individuals, respectively. The phenotypic method showed 2, 27, 41, and 30 isolates as strong biofilm producers, medium biofilm producers, weak biofilm producers, and non-biofilm producers, respectively. The frequency of genes were reported as wzm (47%), markA (69%), pgaAa (65%), and wbbm (47%), respectively. Conclusion: The markA gene plays an important role in biofilm formation and can identify different biofilms in Klebsiella pneumoniae strains. It is also possible to identify bacteria with weak, moderate, and strong biofilms.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45121433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Emami, F. Pakrad, J. Poorolajal, B. Naghshtabrizi, Hamid Reza Gholalikhani, Azam Alizamir
Background and Objective: The high ratio of neutrophils to lymphocytes is a predictor of the risk of myocardial infarction in people who have coronary artery angiography. The purpose of this study was to measure this proportion in the assessment of damage through interventions in patients with non-emergency angioplasty. Materials and Methods: A prospective cohort study was performed on 122 patients referring to Hamadan Farshchian Heart Center, Hamadan, Iran, during 2017 for selected angioplasty. Patients were divided into two groups according to the ratio of neutrophil/ lymphocyte. Data were collected through a checklist and blood test results, including neutrophil/lymphocyte ratio, erythrocyte sedimentation rate (ESR), C-reactive Protein (CRP), Creatine kinase-MB (CKMB), and troponin before angioplasty, as well as 6 and 12 h after angioplasty. The Chi-square test and independent t-test were performed using Stata software (version 14). Results: There was no significant difference between the ESR levels in the two groups before the angioplasty (P=0.431). However, there were significant differences between the two groups 6 h (P=0.001) and 12 h after the angioplasty (P=0.011). There was no significant difference between the blood level of troponin in both groups before (P=0.310) and 6 h after (P=0.186). However, there was a significant difference between the two groups 12 h after the angioplasty (P=0.042). Conclusion: The results showed that an increase in the level of troponin elevated neutrophil/lymphocyte ratio and ESR. However, there was no significant difference in CRP and CKMB levels, although there were significant changes in clinical status.
背景与目的:中性粒细胞与淋巴细胞的高比值是冠状动脉造影患者心肌梗死风险的一个预测指标。本研究的目的是在评估非紧急血管成形术患者通过干预造成的损害时测量这一比例。材料和方法:一项前瞻性队列研究对2017年在伊朗Hamadan Farshchian心脏中心就诊的122例患者进行了选择性血管成形术。根据中性粒细胞/淋巴细胞比例将患者分为两组。通过检查表和血液检查结果收集数据，包括血管成形术前以及血管成形术后6和12小时的中性粒细胞/淋巴细胞比率、红细胞沉降率(ESR)、c反应蛋白(CRP)、肌酸激酶- mb (CKMB)和肌钙蛋白。采用Stata软件(版本14)进行卡方检验和独立t检验。结果:两组血管成形术前ESR水平比较，差异无统计学意义(P=0.431)。然而，两组在血管成形术后6 h (P=0.001)和12 h (P=0.011)有显著差异。两组治疗前(P=0.310)与治疗后6 h (P=0.186)血钙蛋白水平比较，差异无统计学意义。但两组在血管成形术后12 h差异有统计学意义(P=0.042)。结论:肌钙蛋白水平升高可提高中性粒细胞/淋巴细胞比值和ESR。然而，尽管临床状态有明显变化，但CRP和CKMB水平无显著差异。
{"title":"Relation of Neutrophil to Lymphocyte Ratio with Myocardial Damage in Patients Undergoing Elective Percutaneous Coronary Intervention","authors":"F. Emami, F. Pakrad, J. Poorolajal, B. Naghshtabrizi, Hamid Reza Gholalikhani, Azam Alizamir","doi":"10.21859/AJCM.25.4.185","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.185","url":null,"abstract":"Background and Objective: The high ratio of neutrophils to lymphocytes is a predictor of the risk of myocardial infarction in people who have coronary artery angiography. The purpose of this study was to measure this proportion in the assessment of damage through interventions in patients with non-emergency angioplasty. Materials and Methods: A prospective cohort study was performed on 122 patients referring to Hamadan Farshchian Heart Center, Hamadan, Iran, during 2017 for selected angioplasty. Patients were divided into two groups according to the ratio of neutrophil/ lymphocyte. Data were collected through a checklist and blood test results, including neutrophil/lymphocyte ratio, erythrocyte sedimentation rate (ESR), C-reactive Protein (CRP), Creatine kinase-MB (CKMB), and troponin before angioplasty, as well as 6 and 12 h after angioplasty. The Chi-square test and independent t-test were performed using Stata software (version 14). Results: There was no significant difference between the ESR levels in the two groups before the angioplasty (P=0.431). However, there were significant differences between the two groups 6 h (P=0.001) and 12 h after the angioplasty (P=0.011). There was no significant difference between the blood level of troponin in both groups before (P=0.310) and 6 h after (P=0.186). However, there was a significant difference between the two groups 12 h after the angioplasty (P=0.042). Conclusion: The results showed that an increase in the level of troponin elevated neutrophil/lymphocyte ratio and ESR. However, there was no significant difference in CRP and CKMB levels, although there were significant changes in clinical status.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44258017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Abbasi, Fahimeh Moradi, F. Esna-Ashari, M. Seifrabiei, گروه بیماریهای داخلی ، دانشکده پزشکی، دانشگاه علوم پزشک همدان, دانشگاه علوم پزشکی همدان, گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی ه همدان
Background and Objective: Lung cancer is one of the most common types of cancer and the main reason of cancer-caused mortality in Iran. The awareness of cancer epidemiologic and pathologic characteristics helps to prevent the prevalence and incidence of cancer. Materials and Methods: This comparative descriptive study was conducted on patients with lung cancer referring to Ekbatan and Shahid Beheshti Hospitals during 2001-2016. Risk factors as well as clinical and demographic data were collected from medical records. Results: The mean age of the patients was 61.11 ±12.23 years and 166 patients (83%) were male. A total number of 120 (66.7%) patients lived in urban areas. The frequency of patients who had a positive history for consumption of opioid, industrial drugs, cigarette, and hookah were 2%, 0%, 42.2%, and 1%, respectively. The most common symptoms were cough and dyspnea. The time interval between the appearance of clinical signs and diagnosis was 5.32 months. The most common paraneoplastic symptom was bone pain (45.5%), and the most frequent pathologic form was squamous cell carcinoma (33.5%). The right upper lobe (27.5%) and left upper lobe (23.5%) were the most common lobes. Conclusion: Since the time interval between clinical signs and diagnosis was long and squamous cell carcinoma was the most common type of cancer, it is important to control risk factors, specifically smoking, to prevent cancer.
{"title":"Epidemiological and Pathological Study of Lung Cancer in Patients Referred to Ekbatan and Shahid Beheshti Hospitals in Hamadan during 2001 - 2016","authors":"M. Abbasi, Fahimeh Moradi, F. Esna-Ashari, M. Seifrabiei, گروه بیماریهای داخلی ، دانشکده پزشکی، دانشگاه علوم پزشک همدان, دانشگاه علوم پزشکی همدان, گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی ه همدان","doi":"10.21859/AJCM.25.4.236","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.236","url":null,"abstract":"Background and Objective: Lung cancer is one of the most common types of cancer and the main reason of cancer-caused mortality in Iran. The awareness of cancer epidemiologic and pathologic characteristics helps to prevent the prevalence and incidence of cancer. Materials and Methods: This comparative descriptive study was conducted on patients with lung cancer referring to Ekbatan and Shahid Beheshti Hospitals during 2001-2016. Risk factors as well as clinical and demographic data were collected from medical records. Results: The mean age of the patients was 61.11 ±12.23 years and 166 patients (83%) were male. A total number of 120 (66.7%) patients lived in urban areas. The frequency of patients who had a positive history for consumption of opioid, industrial drugs, cigarette, and hookah were 2%, 0%, 42.2%, and 1%, respectively. The most common symptoms were cough and dyspnea. The time interval between the appearance of clinical signs and diagnosis was 5.32 months. The most common paraneoplastic symptom was bone pain (45.5%), and the most frequent pathologic form was squamous cell carcinoma (33.5%). The right upper lobe (27.5%) and left upper lobe (23.5%) were the most common lobes. Conclusion: Since the time interval between clinical signs and diagnosis was long and squamous cell carcinoma was the most common type of cancer, it is important to control risk factors, specifically smoking, to prevent cancer.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43113416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
بررسی فراوانی اختلالات آزمایشگاهی در افراد مراجعهکننده با خارش مزمن به درمانگاه پوست بیمارستان فرشچیان همدان در سال 1396 , بررسی فراوانی اختلالات آزمایشگاهی در افراد مراجعهکننده با خارش مزمن به درمانگاه پوست بیمارستان فرشچ... , کتابخانه الکترونیک و دیجیتال - آذرسا
{"title":"Frequency of Laboratory Abnormalities in Patients with Chronic Pruritus Admitted to the Dermatology Clinic of Farshchian Hospital in Hamadan, Iran, in 2017","authors":"Zahra Bahiraei, Z. Sanaei, P. Alirezaei","doi":"10.21859/AJCM.25.4.230","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.230","url":null,"abstract":"بررسی فراوانی اختلالات آزمایشگاهی در افراد مراجعهکننده با خارش مزمن به درمانگاه پوست بیمارستان فرشچیان همدان در سال 1396 , بررسی فراوانی اختلالات آزمایشگاهی در افراد مراجعهکننده با خارش مزمن به درمانگاه پوست بیمارستان فرشچ... , کتابخانه الکترونیک و دیجیتال - آذرسا","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41760079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Salemi, A. Shokri, H. Karkeabadi, Leili Tapak, Mona Bashari
Background and Objective: The preparation of the root canal (i.e., cleaning and shaping) is the main step in the endodontic treatment. The nickel-titanium rotary files result in fewer errors during the preparation of curved canals. This study aimed to compare the transportation of Neolix and Reciproc rotary systems in curved canals using cone beam computed tomography (CBCT). Materials and Methods: In this experimental study, 70 extracted curved premolar teeth from patients referred to dentistry faculty were assigned into two groups (n=35). The preparation of the canals was performed by the Neolix and Reciproc rotary systems. Remaining dentin thickness, transportation, and canal-centering ratio were evaluated and compared using CBCT images before and after the instrumentation. The data were analyzed in SPSS software (version.19) through ANOVA, independent t-test, and paired t-test. Results: There was a significant difference in terms of remaining dentin thickness in three sections of 3, 5, and 7 mm from the apex, before and after the instrumentation regarding the level of mesiodistal and buccolingual. However, no significant difference was observed in terms of the transportation in three sections of 3, 5, and 7 mm from the apex in both Neolix and Reciproc systems. Conclusion: According to the results, both Neolix and Reciproc rotary systems showed high efficacy in root canal shaping. The amount of transportation in these systems during preparation of curved canals was very low leading to the protection of canal-centering ratio.
{"title":"Comparison of Transportation within Reciproc and Neolix Rotary Systems in Curved Root Canals Using Cone Beam Computed Tomography","authors":"F. Salemi, A. Shokri, H. Karkeabadi, Leili Tapak, Mona Bashari","doi":"10.21859/AJCM.25.4.222","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.222","url":null,"abstract":"Background and Objective: The preparation of the root canal (i.e., cleaning and shaping) is the main step in the endodontic treatment. The nickel-titanium rotary files result in fewer errors during the preparation of curved canals. This study aimed to compare the transportation of Neolix and Reciproc rotary systems in curved canals using cone beam computed tomography (CBCT). Materials and Methods: In this experimental study, 70 extracted curved premolar teeth from patients referred to dentistry faculty were assigned into two groups (n=35). The preparation of the canals was performed by the Neolix and Reciproc rotary systems. Remaining dentin thickness, transportation, and canal-centering ratio were evaluated and compared using CBCT images before and after the instrumentation. The data were analyzed in SPSS software (version.19) through ANOVA, independent t-test, and paired t-test. Results: There was a significant difference in terms of remaining dentin thickness in three sections of 3, 5, and 7 mm from the apex, before and after the instrumentation regarding the level of mesiodistal and buccolingual. However, no significant difference was observed in terms of the transportation in three sections of 3, 5, and 7 mm from the apex in both Neolix and Reciproc systems. Conclusion: According to the results, both Neolix and Reciproc rotary systems showed high efficacy in root canal shaping. The amount of transportation in these systems during preparation of curved canals was very low leading to the protection of canal-centering ratio.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49583286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Sorkhabi, P. Khatibian, دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز
Background and Objective: Keratoconus is a disorder in cornea characterized by constant thinning and prominence that can result in vision defect. Due to ultrasonic changes in the corneal structure caused by keratoconus disease, its rigidity and biomechanical properties are subject to some changes. In this regard, the present study was conducted to determine the correlation of biomechanical features of keratoconus patients with the severity of the disease. Materials and Methods: The case group was selected from the patients with keratoconus who referred to the Corneal Clinic of Nikookari Hospital in Tabriz and the controls had no eye diseases. Corneal biomechanics, corneal hysteresis, and corneal resistance factor were evaluated in all the samples using an ocular response analyzer device. Results: The present study was carried out on 213 keratoconus eyes and 179 normal eyes. The mean scores of corneal hysteresis were obtained at 13.49±1.34 and 7.67±1.01 mmHg for normal and keratoconus eyes, respectively, which were significantly different between the two groups. The differences between the corneal hysteresis of mild (8.86 mm Hg), moderate (8.30 mm Hg), and severe (7.10 mm Hg) keratoconus eyes were also significant. The mean scores of the corneal resistance factor were reported as 12.68±1.15 and 7.36±1.07 mmHg for normal and keratoconus eyes, respectively, which were significantly different between the two groups. The differences between the corneal resistance factor of mild (8.55 mm Hg), moderate (8.05 mm Hg), and severe (6.76 mm Hg) keratoconus eyes were also significant. Conclusion: The obtained results of the present study showed that corneal hysteresis and corneal resistance factor were lower in keratoconus eyes, compared to those in normal eyes and decreased with the severity of the disease.
背景与目的:圆锥角膜是一种以不断变薄和突出为特征的角膜疾病，可导致视力缺陷。圆锥角膜病变引起的超声对角膜结构的改变，使其硬度和生物力学性能发生一定的改变。在这方面，本研究旨在确定圆锥角膜患者的生物力学特征与疾病严重程度的相关性。材料与方法:病例组选自大不里士Nikookari医院角膜门诊就诊的圆锥角膜患者，对照组无眼部疾病。使用眼反应分析仪对所有样本的角膜生物力学、角膜迟滞和角膜阻力因子进行评估。结果:对圆锥角膜213只眼和正常眼179只眼进行了观察。正常眼和圆锥角膜眼的平均迟滞评分分别为13.49±1.34和7.67±1.01 mmHg，两组差异有统计学意义。轻度(8.86 mm Hg)、中度(8.30 mm Hg)、重度(7.10 mm Hg)圆锥角膜的角膜迟滞差异也有统计学意义。正常眼和圆锥角膜的角膜阻力因子平均评分分别为12.68±1.15和7.36±1.07 mmHg，两组比较差异有统计学意义。轻度(8.55 mm Hg)、中度(8.05 mm Hg)、重度(6.76 mm Hg)圆锥角膜的角膜阻力因子差异也有统计学意义。结论:本研究结果显示圆锥角膜的角膜迟滞和角膜抵抗因子较正常眼低，且随病情的加重而降低。
{"title":"Correlation of Biomechanical Features of Keratoconus Patients with Severity of Disease","authors":"R. Sorkhabi, P. Khatibian, دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز","doi":"10.21859/AJCM.25.4.200","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.200","url":null,"abstract":"Background and Objective: Keratoconus is a disorder in cornea characterized by constant thinning and prominence that can result in vision defect. Due to ultrasonic changes in the corneal structure caused by keratoconus disease, its rigidity and biomechanical properties are subject to some changes. In this regard, the present study was conducted to determine the correlation of biomechanical features of keratoconus patients with the severity of the disease. Materials and Methods: The case group was selected from the patients with keratoconus who referred to the Corneal Clinic of Nikookari Hospital in Tabriz and the controls had no eye diseases. Corneal biomechanics, corneal hysteresis, and corneal resistance factor were evaluated in all the samples using an ocular response analyzer device. Results: The present study was carried out on 213 keratoconus eyes and 179 normal eyes. The mean scores of corneal hysteresis were obtained at 13.49±1.34 and 7.67±1.01 mmHg for normal and keratoconus eyes, respectively, which were significantly different between the two groups. The differences between the corneal hysteresis of mild (8.86 mm Hg), moderate (8.30 mm Hg), and severe (7.10 mm Hg) keratoconus eyes were also significant. The mean scores of the corneal resistance factor were reported as 12.68±1.15 and 7.36±1.07 mmHg for normal and keratoconus eyes, respectively, which were significantly different between the two groups. The differences between the corneal resistance factor of mild (8.55 mm Hg), moderate (8.05 mm Hg), and severe (6.76 mm Hg) keratoconus eyes were also significant. Conclusion: The obtained results of the present study showed that corneal hysteresis and corneal resistance factor were lower in keratoconus eyes, compared to those in normal eyes and decreased with the severity of the disease.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46143006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe and potentially life-threatening reactions. In spite of the low prevalence of these conditions, they are of utmost significance due to their catastrophic complications and mortality. The SJS and TEN are mostly caused by a reaction to a drug; however, in some cases, they result from infections. The aim of this study was to investigate the epidemiologic, etiologic, and clinical characteristics of the patients admitted to Sina Hospital in Hamadan, Iran, due to SJS and TEN during a 16-year period. Materials and Methods: This cross-sectional descriptive study was conducted on the patients with SJS and TEN admitted to Sina Hospital during the last 16 years (i.e., 2002-2018). The data analyzed in the present study included age, gender, causative drug, length of hospital stay, received treatment, and complications. Results: A total of 47 patients, consisting of 21 males and 26 females, were investigated in this study. Out of the 47 patients, 34, 9, and 4 cases were diagnosed with SJS, TEN, and SJS/TEN overlap, respectively. Regarding the etiology of these conditions, 45 cases (95.7%) were drug-related, while the remaining 2 cases were caused by reasons other than drugs. The most common causative drugs were antimicrobials (36.1%), followed by antiepileptics (27.6%) and nonsteroidal anti-inflammatory drug (17 %). Furthermore, there one case caused by reaction to allopurinol, and another case resulted from reactions to rabies vaccine. The remaining cases were either non-drug related or multi-drug related. The most common complications were infections (21.2%), followed by ocular problems (19.1%) and gastrointestinal bleeding (2.1%). Conclusion: As the findings indicated, antimicrobials were the most common causative drugs of SJS and TEN. The physicians should be aware of the clinical manifestations of SJS and TEN with regard to the severe complications of these conditions, including ocular damages, and their risk of mortality. Moreover, it is required to enhance public awareness regarding the avoidance of self-medication with antimicrobial drugs.
{"title":"Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Patients Admitted to Sina Hospital in Hamadan, Iran: A 16-year study","authors":"P. Alirezaei, M. Sobhan, A. Saadatmand","doi":"10.21859/AJCM.25.4.193","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.193","url":null,"abstract":"Background and Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe and potentially life-threatening reactions. In spite of the low prevalence of these conditions, they are of utmost significance due to their catastrophic complications and mortality. The SJS and TEN are mostly caused by a reaction to a drug; however, in some cases, they result from infections. The aim of this study was to investigate the epidemiologic, etiologic, and clinical characteristics of the patients admitted to Sina Hospital in Hamadan, Iran, due to SJS and TEN during a 16-year period. Materials and Methods: This cross-sectional descriptive study was conducted on the patients with SJS and TEN admitted to Sina Hospital during the last 16 years (i.e., 2002-2018). The data analyzed in the present study included age, gender, causative drug, length of hospital stay, received treatment, and complications. Results: A total of 47 patients, consisting of 21 males and 26 females, were investigated in this study. Out of the 47 patients, 34, 9, and 4 cases were diagnosed with SJS, TEN, and SJS/TEN overlap, respectively. Regarding the etiology of these conditions, 45 cases (95.7%) were drug-related, while the remaining 2 cases were caused by reasons other than drugs. The most common causative drugs were antimicrobials (36.1%), followed by antiepileptics (27.6%) and nonsteroidal anti-inflammatory drug (17 %). Furthermore, there one case caused by reaction to allopurinol, and another case resulted from reactions to rabies vaccine. The remaining cases were either non-drug related or multi-drug related. The most common complications were infections (21.2%), followed by ocular problems (19.1%) and gastrointestinal bleeding (2.1%). Conclusion: As the findings indicated, antimicrobials were the most common causative drugs of SJS and TEN. The physicians should be aware of the clinical manifestations of SJS and TEN with regard to the severe complications of these conditions, including ocular damages, and their risk of mortality. Moreover, it is required to enhance public awareness regarding the avoidance of self-medication with antimicrobial drugs.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49430593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aida Mirza Aghasi, S. Ghorbian, گروه ژنتیک مولکولی، واحد اهر، دانشگاه آزاد اسلامی، اهر
{"title":"Evaluation of the PRSS8 Gene Methylation Pattern in Patients with Esophageal Squamous Cell Carcinoma","authors":"Aida Mirza Aghasi, S. Ghorbian, گروه ژنتیک مولکولی، واحد اهر، دانشگاه آزاد اسلامی، اهر","doi":"10.21859/AJCM.25.4.207","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.207","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47352646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
فاطمه اسلامی, مهدی علیزاده, محمد ربیعی, نسرین محبی امام
{"title":"Comparison of Amniotic Membrane Transplantation and Conjunctival Autograft Transplantation for the Treatment of Pterygium","authors":"فاطمه اسلامی, مهدی علیزاده, محمد ربیعی, نسرین محبی امام","doi":"10.21859/AJCM.25.4.215","DOIUrl":"https://doi.org/10.21859/AJCM.25.4.215","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43166408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Nadi, M. Ahmadpanah, Nasim Karimi, E. Nadi, دانشگاه علوم پزشکی همدان
Background and Objective: Chronic obstructive pulmonary disease (COPD) is a worldwide health problem with increasing prevalence. It is often associated with negative health outcomes, including depression. Therefore, the aim of this study was to determine the prevalence of depression in patients with COPD. Materials and Methods: This cross-sectional study with a descriptiveanalytic design was conducted on 103 patients referring to the respiratory disease clinic and admitted to the pulmonary disease department of Shahid Beheshti teaching Hospital, Hamadan, Iran from April to September 2018. The inclusion criteria were the diagnosis of severe and very severe COPD according to the medical history, physical examination, and standard spirometric methods. The patients with lack of bereavement, trauma, and the use of antidepressant drugs were excluded from the study. Depression levels were measured using 21-items Beck II depression questionnaire. Results: The results of the study showed that 57 patients (55.3%) were males and 46 cases (44.7%) were females. The majority of the subjects (33%) were in the age group of 50-59 years old. According to the results, the prevalence of depression in the study population was 66%. There was a significant relationship between spirometric parameters of forced expiratory flow at 2575% of the pulmonary volume, forced expiratory volume at 1 second and COPD severity (P=0.024, P=0.003). Conclusion: With regard to the high prevalence of depression among people with severe and very severe COPD, it is necessary to consider psychological counseling for patients.
{"title":"Investigation of the Prevalence of Depression in Patients with Chronic Obstructive Pulmonary Disease in Hamadan in 2018","authors":"F. Nadi, M. Ahmadpanah, Nasim Karimi, E. Nadi, دانشگاه علوم پزشکی همدان","doi":"10.21859/ajcm.25.3.170","DOIUrl":"https://doi.org/10.21859/ajcm.25.3.170","url":null,"abstract":"Background and Objective: Chronic obstructive pulmonary disease (COPD) is a worldwide health problem with increasing prevalence. It is often associated with negative health outcomes, including depression. Therefore, the aim of this study was to determine the prevalence of depression in patients with COPD. Materials and Methods: This cross-sectional study with a descriptiveanalytic design was conducted on 103 patients referring to the respiratory disease clinic and admitted to the pulmonary disease department of Shahid Beheshti teaching Hospital, Hamadan, Iran from April to September 2018. The inclusion criteria were the diagnosis of severe and very severe COPD according to the medical history, physical examination, and standard spirometric methods. The patients with lack of bereavement, trauma, and the use of antidepressant drugs were excluded from the study. Depression levels were measured using 21-items Beck II depression questionnaire. Results: The results of the study showed that 57 patients (55.3%) were males and 46 cases (44.7%) were females. The majority of the subjects (33%) were in the age group of 50-59 years old. According to the results, the prevalence of depression in the study population was 66%. There was a significant relationship between spirometric parameters of forced expiratory flow at 2575% of the pulmonary volume, forced expiratory volume at 1 second and COPD severity (P=0.024, P=0.003). Conclusion: With regard to the high prevalence of depression among people with severe and very severe COPD, it is necessary to consider psychological counseling for patients.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43881791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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