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Evaluation of the Expression Levels of Endothelin-1 and its Receptor (ETAR) in Dental Lamina during Different Stages of Development of Human Fetal Teeth 人胎牙不同发育阶段牙层内皮素-1及其受体(ETAR)表达水平的评价
Q4 Medicine Pub Date : 2021-09-01 DOI: 10.52547/ajcm.28.2.79
S. Irani, S. Alimohammadi, Tahmineh Najafian
Background and Objective: Due to the significant importance of the teeth in mastication, speech, and aesthetics, it is necessary to identify all involved genes in the tooth development. Therefore, this study aimed to evaluate the role of endothelin-1 and its A receptor in dental lamina in different stages of tooth development. Materials and Methods: This cross-sectional study included 33 fetal samples that were divided into three groups regarding gestational age. All samples were then stained by immunohistochemistry. Subsequently, the analysis was conducted in SPSS software (version 20) through the two-way ANOVA and Tukey's tests to examine the differences between the variables. A p-value less than 0.05 was considered statistically significant. Results: There was a significant difference between the gestational age and the expression level of endothelin-1 in dental lamina (P<0.001). In addition, a significant relationship was observed between age and anatomic area (P<0.001). There was also a significant difference between the gestational age and the expression level of endothelin-1 receptor (ETAR) in dental lamina (P<0.001). A significant association was found between gestational age and anatomic area (P<0.001). Conclusion: The expression levels of endothelin-1 and its receptor (ETAR) in each jaw were higher in anterior dental lamina, compared to posterior dental lamina. These results may confirm the role of endothelin-1 and its receptor in cell proliferation, differentiation of dental lamina, and calcium ion transport during tooth development.
背景与目的:由于牙齿在咀嚼、言语和美学方面具有重要意义,因此有必要确定牙齿发育中的所有相关基因。因此,本研究旨在评估内皮素-1及其A受体在牙齿发育不同阶段牙板中的作用。材料和方法:这项横断面研究包括33个胎儿样本,根据胎龄分为三组。然后通过免疫组织化学对所有样品进行染色。随后,在SPSS软件(版本20)中通过双向ANOVA和Tukey检验进行分析,以检验变量之间的差异。p值小于0.05被认为具有统计学意义。结果:牙周组织中内皮素-1的表达水平与胎龄有显著性差异(P<0.001),年龄与解剖面积有显著关系(P<0.001),胎龄与牙板内皮素-1受体(ETAR)表达水平也有显著差异(P<0.01),胎周与解剖面积也有显著相关性(P<0.05)与后牙板相比,每个颌骨的前牙板的比例更高。这些结果可能证实内皮素-1及其受体在细胞增殖、牙板分化和牙齿发育过程中钙离子转运中的作用。
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引用次数: 0
Evaluation of Serum Levels of Vitamin D, Ferritin, and Hemoglobin in Suicide Attempters Admitted or Outpatients Referred to Hospitals and Psychiatric Clinics of Rafsanjan University of Medical Sciences 拉夫桑詹医科大学医院和精神病诊所收治或门诊自杀未遂者血清维生素D、铁蛋白和血红蛋白水平的评估
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.36
A. Kermanian, Neda Esmail Khani, M. Mokhtaree, A. Sayadi
Background and Objective: Suicide occurs due to a variety of causes, from heredity and biological factors to environmental factors. The present study aimed to evaluate the serum levels of vitamin D, ferritin, and hemoglobin in patients with attempted suicide referring to hospitals and compare them with the control group. Materials and Methods: A comparison was made between the serum levels of vitamin D, ferritin, and hemoglobin of 60 suicidal patients referring to Ali ibn Abitaleb hospital of Rafsanjan from March to september 2020 and those of 60 relatives of selected patients with no history of suicide. The control group completed the Beck Suicide Thought Questionnaire (BSTQ). Chisquare, ANOVA, independent t-test, Mann-Whitney U test, and KruskalWallis statistical tests were used to analyze the data. Results: The serum level of vitamin D in Patient with attempted suicide was lower, compared to that in controls (P=0.025). Among the age group of 1535 years, serum levels of vitamin D were lower than those in the control group (P=0.039). Moreover, serum ferritin level in the attempted suicide group was lower than that in the control group (P=0.003). Serum ferritin level was significantly lower among the suidide attempters aged 15-15 years (P= 0.003), men with attempted suicide (P= 0.003) and suicidal women (P= 0.045), as compared to the control group. Conclusion: As demonstratedd by the results of the present study, vitamin D deficiency and anemia can be two major risk factors for suicide. Therefore, it is necessary to identify and treat these deficiencies in people with psychological disorders, such as depression.
背景与目的:自杀的发生有多种原因,从遗传、生物因素到环境因素。本研究旨在评估医院就诊的自杀未遂患者的血清维生素D、铁蛋白和血红蛋白水平,并将其与对照组进行比较。材料和方法:比较2020年3月至9月在拉夫桑詹Ali ibn Abitaleb医院就诊的60名自杀患者与60名无自杀史患者亲属的血清维生素D、铁蛋白和血红蛋白水平。对照组完成贝克自杀思想调查表(BSTQ)。Chisquare、ANOVA、独立t检验、Mann-Whitney U检验和KruskalWallis统计检验用于分析数据。结果:自杀未遂患者血清维生素D水平低于对照组(P=0.025),1535岁年龄组血清维生素D含量低于对照组,自杀未遂组血清铁蛋白水平低于对照组(P=0.003),15~15岁自杀未遂者(P=0.0003)、自杀未遂男性(P=0.003)和自杀女性(P=0.045)血清铁蛋白含量显著低于对照组。结论:本研究结果表明,维生素D缺乏和贫血可能是自杀的两个主要危险因素。因此,有必要识别和治疗抑郁症等心理障碍患者的这些缺陷。
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引用次数: 1
Effects of Pyridoxine on Improving Attention Deficit Hyperactivity Disorder Symptoms among Children under Ritalin Treatment 吡哆醇对利他林治疗儿童注意缺陷多动障碍症状的改善作用
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.29252/AJCM.28.1.5
Afshin Fayazi, Shahin Seifodin, A. Moradi
Background and Objective: Attention Deficit Hyperactivity Disorder (ADHD) is a common neuropsychological disorder among children that might lead to disruption of daily activities. Therefore, this study aimed to determine the effects of pyridoxine on the treatment and reduction of symptoms severity in children with ADHD under Ritalin treatment. Materials and Methods: This clinical trial included a total of 50 children with ADHD in the age range of 5-12 years who were referred to Emam clinic of Children’s Neurology and Be’sat Hospital, Hamedan, Iran, and were selected using a convenience sampling approach. The participants were divided into two similar treatment groups. One group only received Ritalin as the treatment and the second group received Pyridoxine and Ritalin together. The change in the severity of the symptoms was analyzed using Conners Rating Scale. Results: The patients in the two treatment groups were identical in terms of age and gender. The mean score of disease severity in both groups reduced up to 23.92 and 32.12 units, respectively, compared to those before intervention (P<0.001). In addition, there was a statistically significant difference between the severity of symptoms before and after intervention in both groups following the intervention (the mean scores of the severity of symptoms were obtained at 65.09 and 54.00, respectively) in children with
背景与目的:注意力缺陷多动障碍(ADHD)是一种常见的儿童神经心理障碍,可能导致日常活动中断。因此,本研究旨在确定吡哆醇在利他林治疗下对多动症儿童的治疗和减轻症状严重程度的影响。材料和方法:这项临床试验共包括50名年龄在5-12岁之间的多动症儿童,他们被转诊到伊朗哈梅丹的Emam儿童神经病学诊所和Be’sat医院,并使用方便的抽样方法进行选择。参与者被分为两个相似的治疗组。一组仅接受利他林治疗,第二组同时接受吡哆醇和利他林治疗。使用Conners评定量表分析症状严重程度的变化。结果:两组患者的年龄和性别完全相同。与干预前相比,两组患者的疾病严重程度平均得分分别降低了23.92和32.12个单位(P<0.001),干预前后两组的症状严重程度在统计学上存在显著差异(症状严重程度的平均得分分别为65.09和54.00)
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引用次数: 0
A Case Report of Giant Congenital Melanocytic Nevus 先天性巨大黑色素痣1例报告
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.66
M. Alipour, K. Khashei Varnamkhasti, Marzieh Eslami Moghaddam, Masumeh Panahi
Background: Giant congenital melanocytic nevus is caused by intrauterine somatic mutations in the genes involved in the mitogen-activated protein kinase pathway. It is a rare melanocytic lesion with a prevalence of 1 per 20,000 live births occurring at birth or shortly thereafter. Case Presentation: Here, we presented the case of a term male neonate with giant congenital melanocytic nevus. He was born to a 33-year-old mother. The initial pediatric examination revealed a skin mosaic pattern in his torso. The pigmented and rough skin of this area, along with several prominent wart-shaped lesions and demarcated borders, confirmed the giant congenital melanocytic nevus. Conclusion: Despite the rarity of this lesion, it is of great importance since it may associate with severe complications, such as malignant melanoma. Therefore, it is necessary to adopt appropriate medical management by recognizing the nature of the lesion.
背景:巨大先天性黑色素细胞痣是由子宫内参与丝裂原活化蛋白激酶途径的基因发生体细胞突变引起的。这是一种罕见的黑色素细胞病变,发病率为出生时或出生后不久每20000名活产中就有1名。病例介绍:在这里,我们介绍了一个足月男性新生儿患有巨大先天性黑色素细胞痣的病例。他是一位33岁的母亲所生。最初的儿科检查显示他的躯干有一个皮肤马赛克图案。这个区域的色素沉着和粗糙的皮肤,以及几个明显的疣状病变和界限分明的边界,证实了巨大的先天性黑色素细胞痣。结论:尽管这种病变很罕见,但它具有重要意义,因为它可能会伴随严重的并发症,如恶性黑色素瘤。因此,有必要通过认识病变的性质来采取适当的医疗管理。
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引用次数: 1
Correlation between Vitamin D Deficiency and Seborrheic Dermatitis in Patients Referred to the Dermatology Clinic of Sina Hospital, Hamadan, Iran 伊朗哈马丹Sina医院皮肤科门诊患者维生素D缺乏与脂溢性皮炎的相关性
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.20
M. Sobhan, E. Khanlarzadeh, Mahrokh Moradi Rozbhani
Background and Objective: Seborrheic dermatitis is one of the most common inflammatory skin diseases that affect the sebaceous glands. Although the exact role of vitamin D in this disease is still not clearly understood, some studies have shown lower serum levels of vitamin D in seborrheic dermatitis patients. This study aimed to investigate the correlation between vitamin D deficiency and seborrheic dermatitis. Materials and Methods: This cross-sectional case-control study was conducted in Sina Hospital, Hamadan, Iran. The study sample included 39 seborrheic dermatitis patients (case group) and 39 healthy individuals (control group) who were matched in terms of gender and age. The groups were then compared regarding serum vitamin D level. Statistical analysis was performed in SPSS software (version 16.0; SPSS Inc.Chicago, IL). Results: There were no significant differences between the two groups in terms of age, gender, educational level, place of residence, and occupational status. The mean serum levels of vitamin D in the case and control groups were 11.82±5.56 and 21.38±6.79ng/ml, respectively (P=0.001). Furthermore, in the case and control groups, 18 (46.2%) and 1 (2.6%) individuals had vitamin D deficiency; 20 (51.3%) and 34 (87.2%) cases had inadequate vitamin D levels; and 1(2.6%) and 4 (10.3%) subjects had adequate levels of vitamin D, respectively. Therefore, the serum level of vitamin D was significantly lower in the case group, compared to the control group (P=0.001). Moreover, the serum level of vitamin D did not correlate with the duration and severity of seborrheic dermatitis disease (P>0.05). Conclusion: According to the findings of this study, patients with seborrheic dermatitis had lower serum vitamin D levels, compared to the general population, which may be related to the pathogenicity of the disease.
背景与目的:脂溢性皮炎是影响皮脂腺的最常见的炎症性皮肤病之一。尽管维生素D在这种疾病中的确切作用尚不清楚,但一些研究表明,脂溢性皮炎患者的血清维生素D水平较低。本研究旨在探讨维生素D缺乏与脂溢性皮炎之间的关系。材料与方法:本横断面病例对照研究在伊朗哈马丹Sina医院进行。研究样本包括39例脂溢性皮炎患者(病例组)和39例性别和年龄相匹配的健康人(对照组)。然后比较各组的血清维生素D水平。采用SPSS软件(16.0版)进行统计分析;SPSS inc .,芝加哥,伊利诺伊州)。结果:两组患者在年龄、性别、文化程度、居住地、职业状况等方面均无显著差异。病例组和对照组血清维生素D水平分别为11.82±5.56、21.38±6.79ng/ml (P=0.001)。此外,在病例组和对照组中,分别有18人(46.2%)和1人(2.6%)缺乏维生素D;20例(51.3%)和34例(87.2%)患者维生素D水平不足;分别有1名(2.6%)和4名(10.3%)受试者维生素D水平充足。因此,与对照组相比,病例组的血清维生素D水平显著降低(P=0.001)。此外,血清维生素D水平与脂溢性皮炎病程和严重程度无相关性(P < 0.05)。结论:根据本研究结果,脂溢性皮炎患者血清维生素D水平低于一般人群,这可能与疾病的致病性有关。
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引用次数: 0
Histopathological Study of Gynecological Cancers in Patients Admitted to Baqiyatallah Hospital in Tehran during 2011-2019 2011-2019年德黑兰Baqiyatallah医院妇科癌症患者的组织病理学研究
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.42
S. Hashemi, M. Akbari, Z. Soleimani
Background and Objective: Each type of cancer has its own histopathological findings that determine the type of treatment regimen and the course of the disease. The present study aimed to histopathologically determine the types of gynecological cancers in patients admitted to Baqiyatallah Hospital over a nine-year period. Materials and Methods: This retrospective study was conducted based on hospital data of patients who were admitted to Baqiyatallah Hospital and underwent any procedure, treatment, and diagnosis of gynecologic cancers during 2011-2019. Patients' information was extracted from hospital integrated archiving system. Results: A total of 404 patients were diagnosed with gynecological cancers between 2011 and 2019. Among these cancers, ovarian cancer with 212 (52.5%) patients was the most common gynecological cancer. Among patients with ovarian cancer, Serous Adenocarcinoma and Endometrioid Adenocarcinoma with 137 (64.6%) and 29 (13.7%) cases had the highest frequency of pathology, respectively. The mean (standard deviation) age of the patients with gynecological cancer was 55.88 (11.51) years. During the study period, there was a relatively increasing trend for ovarian cancer during 2011-19. Conclusion: ovarian cancer with Serous Adenocarcinoma was the most common cancer diagnosed in patients admitted to Baqiyatallah Hospital during 2011-19. The relatively increasing trend of this type of female genital cancers during this 9-year period and the observed age pattern highlight the importance of implementing timely screening and treatment programs.
背景和目的:每种类型的癌症都有自己的组织病理学结果,这些结果决定了治疗方案的类型和疾病的过程。本研究旨在从组织病理学角度确定巴奇亚塔拉医院九年来收治的妇科癌症患者的类型。材料和方法:这项回顾性研究基于2011-2019年间入住巴奇亚塔拉医院并接受任何妇科癌症手术、治疗和诊断的患者的医院数据。从医院综合档案系统中提取患者信息。结果:2011年至2019年间,共有404名患者被诊断为妇科癌症。在这些癌症中,卵巢癌症212例(52.5%)是最常见的妇科癌症。在卵巢癌症患者中,浆液性腺癌和子宫内膜样腺癌的病理发生率最高,分别为137例(64.6%)和29例(13.7%)。妇科癌症患者的平均(标准差)年龄为55.88(11.51)岁。在研究期间,在2011-19年间,卵巢癌症呈相对增加的趋势。结论:卵巢癌症伴浆液性腺癌是2011-19年巴齐亚塔拉医院诊断的最常见的癌症。在这9年的时间里,这类女性生殖器癌症的相对增加趋势和观察到的年龄模式突出了及时实施筛查和治疗计划的重要性。
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引用次数: 0
Comparison of Antibiogram Results of Two Types of Antibiotic Discs and Validation by E.test Method on Bacteria with High Antibiotic Resistance Patterns 两种抗生素纸片的抗体图谱结果比较及E.test法对高耐药菌群的验证
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.59
Hamid Reza Ghasemi Basir, F. Keramat, A. Moradi, Z. Khani, A. Saadatmand
Background and Objective: The increased resistance of microorganisms to common antibiotics is one of the major therapeutic challenges for patients. The present study aimed to compare the antibiogram results of two types of antibiotic discs and validate them by the Epsilometer test (E-test) method on bacteria with high antibiotic resistance patterns. Materials and Methods: This descriptive-analytical study was performed by the census method on 176 patients admitted to different wards of Sina Hospital in Hamadan from March 2016 to March 2019. The patients entered the study with a positive culture result and underwent the antibiogram using two types of discs. Following that, validation was performed by the Etest method in cases with significant differences. Finally, the results were described and analyzed in SPSS software (version 16) at a 95% confidence
背景和目的:微生物对常见抗生素耐药性的增加是患者面临的主要治疗挑战之一。本研究旨在比较两种类型的抗生素圆盘的抗菌谱结果,并通过Epsilometer试验(E试验)方法对具有高抗生素耐药性模式的细菌进行验证。材料和方法:本描述性分析研究采用普查方法,对2016年3月至2019年3月入住哈马丹Sina医院不同病房的176名患者进行了研究。患者以阳性培养结果进入研究,并使用两种类型的椎间盘进行了抗体谱检查。之后,在存在显著差异的情况下,采用Etest方法进行验证。最后,在SPSS软件(版本16)中对结果进行描述和分析,置信度为95%
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引用次数: 0
Comparison of Serum Level of Vitamin D3 in Covid-19 Patients and Non-Infected Individuals Covid-19患者与非感染者血清维生素D3水平的比较
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.13
Alireza Nikoonejad, Ali Shafizadeh Arjomandi, S. Dodangeh, A. Allami
Background and Objective: Coronavirus Disease 2019 (COVID-19) has caused the death of many people, mainly by causing respiratory failure. The method of quarantine for the control of this disease leads to deprivation of vitamin D3 production. In this regard, this study aimed to investigate the relationship between serum vitamin D3 level and risk of COVID-19. Materials and Methods: This case-control study was conducted in BouAli Sina Hospital in Qazvin, Iran in September 2020. The statistical population of the case group included patients with COVID-19 referred to this center, while the control group comprised non-COVID-19 patients who referred to the center. Vitamin D3 levels of the participants were assessed and the findings were recorded. The collected data were analyzed using statistical
背景与目的:2019冠状病毒病(新冠肺炎)已导致许多人死亡,主要是由于引起呼吸衰竭。控制这种疾病的隔离方法导致维生素D3的生产被剥夺。在这方面,本研究旨在探讨血清维生素D3水平与新冠肺炎风险之间的关系。材料和方法:本病例对照研究于2020年9月在伊朗Qazvin的BouAli Sina医院进行。病例组的统计人群包括转诊至该中心的新冠肺炎患者,而对照组包括转诊到该中心的非新冠肺炎患者。对参与者的维生素D3水平进行评估,并记录结果。使用统计学方法对收集的数据进行分析
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引用次数: 0
Maternal and Neonatal Outcomes in Expectant Management of Early-Onset Severe Preeclampsia 早期发病的重度子痫前期孕妇和新生儿的预期治疗结果
Q4 Medicine Pub Date : 2021-06-01 DOI: 10.52547/ajcm.28.1.28
Z. Tabasi, E. Mesdaghinia, Masoumeh Abedzadeh-kalahroudi, H. Akbari, Mahsa Bandagi-Motlagh
Background and Objective: Preeclampsia is one of the most critical complications of pregnancy observed in 2%-8% of all pregnancies. Severe preeclampsia has many maternal and neonatal complications that are more prevalent in early-onset preeclampsia. The present study aimed to determine the prevalence of maternal and neonatal outcomes of expectant management of severe preeclampsia before 34 weeks of gestation. Materials and Methods: In this retrospective descriptive study, the medical records of 55 mothers who had severe preeclampsia before 34 weeks of gestation and underwent expectant management and those of their neonates within 2014-2019 in Kashan, Iran, were reviewed. The information extracted from the medical records included maternal and neonatal demographic variables and outcomes. All data were analyzed in SPSS software (version 16) using descriptive and inferential statistics. The p-values of less than 0.05 were considered significant. Results: In this study, the rates of seizure, post-partum hemorrhage, intensive care unit admission, and platelet decline were 5.5%, 1.8%, 3.6%, and 7.3%, respectively. Moreover, 10.9% of mothers had renal failure, and therefore, elevated liver enzymes and hemolysis. Among the neonates, 44.7% and 12.7% of the cases had respiratory distress syndrome (RDS) and low Apgar scores, respectively. It was also revealed that 6.4% of the neonates had convulsions and pneumothorax (PTX), and neonatal mortality was observed in 6.4% of them. No significant relationship was observed between maternal outcomes and gestational age and between neonatal outcomes and the number of deliveries (P>0.05). However, renal failure outcomes had a significant relationship with the number of deliveries (P=0.023), meaning that all mothers with renal failure were nulliparous. It was found that gestational age had a significant relationship with the outcomes of neonatal death, low 5-minute Apgar score, low birth weight, RDS, and PTX (P<0.05); in other words, lower gestational age led to higher mentioned neonatal outcomes. Conclusion: Expectant management of early-onset preeclampsia was beneficial for neonates, and the implementation of regular and close monitoring in equipped centers would prevent the increase of maternal
背景与目的:先兆子痫是妊娠期最严重的并发症之一,发生率为2%-8%。重度先兆子痫有许多母体和新生儿并发症,在早发性先兆子痫中更为普遍。本研究旨在确定妊娠34周前严重先兆子痫孕妇和新生儿预期治疗结果的患病率。材料和方法:在这项回顾性描述性研究中,回顾了伊朗卡山市55名在妊娠34周前患有严重先兆子痫并接受待产治疗的母亲及其2014-2019年新生儿的医疗记录。从医疗记录中提取的信息包括产妇和新生儿的人口统计变量和结果。所有数据在SPSS软件(版本16)中使用描述性和推断统计学进行分析。小于0.05的p值被认为是显著的。结果:在本研究中,癫痫发作率、产后出血率、重症监护室入院率和血小板下降率分别为5.5%、1.8%、3.6%和7.3%。此外,10.9%的母亲患有肾衰竭,因此肝酶升高和溶血。在新生儿中,44.7%和12.7%的病例分别患有呼吸窘迫综合征(RDS)和低Apgar评分。研究还显示,6.4%的新生儿有抽搐和肺气肿(PTX),其中6.4%的婴儿死亡。母体结局与胎龄、新生儿结局与分娩次数之间没有显著关系(P>0.05)。然而,肾功能衰竭结局与分娩数量之间有显著关系(P=0.023),这意味着所有肾功能衰竭的母亲都是未产妇。研究发现,胎龄与新生儿死亡、低5分钟Apgar评分、低出生体重、RDS和PTX的结局有显著关系(P<0.05);换句话说,较低的胎龄会导致较高的新生儿结局。结论:对早发性先兆子痫的期望管理对新生儿是有益的,在设备齐全的中心实施定期和密切的监测将防止孕产妇数量的增加
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引用次数: 0
بررسی وضعیت استرس، اضطراب، افسردگی و اختلال خواب دانشجویان پزشکی دانشگاه علوم پزشکی همدان طی همهگیری کووید 19 科威特医科大学学生压力、焦虑、抑郁和睡眠障碍状况的研究
Q4 Medicine Pub Date : 2021-03-15 DOI: 10.52547/AJCM.27.4.238
زهرا خواجه میری, زهرا رضوی, شقایق محمدی
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引用次数: 2
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pzshkhy blyny bn syn
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