{"title":"Comparison of Word Recognition Score in White Noise in Patients with Cochlear Implant Prosthesis toward Patients with Hearing Aid","authors":"Seyede Faranak Emami","doi":"10.52547/ajcm.27.3.171","DOIUrl":"https://doi.org/10.52547/ajcm.27.3.171","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46331084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Asadi, H. Saremi, Hojat Radinmehr, Soulmaz Rahbar, Ailin Talimkhani, Gholamreza Hajvalie, L. Majidi
{"title":"The Comparison of Therapeutic Ultrasound and Laser Therapy in Treatment of Mild to Moderate Carpal Tunnel Syndrome:\u0000 A Randomized Clinical Trial","authors":"M. Asadi, H. Saremi, Hojat Radinmehr, Soulmaz Rahbar, Ailin Talimkhani, Gholamreza Hajvalie, L. Majidi","doi":"10.52547/ajcm.27.3.149","DOIUrl":"https://doi.org/10.52547/ajcm.27.3.149","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49305145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objective: Mycobacterium tuberculosis is an intracellular pathogen, and the main target of this bacterium is the lungs, upper respiratory system, and their mucous membranes leading to acute or chronic infection of the respiratory tract. The purpose of this study was to investigate the microRNA 21 (miR-21) expression levels in the patients suspected of Mycobacterium tuberculosis. Materials and Methods: The present study was a case-by-case study, and the results were compared between the two groups of patients and healthy individuals. The serum samples were collected from 200 patients suspected of Mycobacterium tuberculosis during a 3-year period in the hospitals of Kerman, Iran. The expression level of the extracted miR-21 was analyzed using real-time polymerase chain reaction. Results: There was no significant difference in the serum miR-21 gene expression in the symptomatic patients with negative smear and negative purified protein derivative (PPD) skin test. However, the patients with positive smear and negative PPD, positive PPD and negative smear, and positive smear and positive PPD showed a significant increase in the miR21 gene expression (P<0.05). Conclusion: The obtained results confirmed the need for more accurate diagnostic methods, especially molecular techniques, for the detection of M. tuberculosis infection as late detection of infection can eliminate the possibility of effective treatment and endanger the lives of individuals. Due to the correlation between miR-21 and this infection, the miR-21 inhibitors can also be used for the treatment of the disease.
{"title":"Evaluation of Serum miR-21 Expression Level in Patients Suspected of Mycobacterium tuberculosis","authors":"H. Moghadam, B. Kheirkhah, N. Pour, A. Kariminik","doi":"10.29252/AJCM.27.3.184","DOIUrl":"https://doi.org/10.29252/AJCM.27.3.184","url":null,"abstract":"Background and Objective: Mycobacterium tuberculosis is an intracellular pathogen, and the main target of this bacterium is the lungs, upper respiratory system, and their mucous membranes leading to acute or chronic infection of the respiratory tract. The purpose of this study was to investigate the microRNA 21 (miR-21) expression levels in the patients suspected of Mycobacterium tuberculosis. Materials and Methods: The present study was a case-by-case study, and the results were compared between the two groups of patients and healthy individuals. The serum samples were collected from 200 patients suspected of Mycobacterium tuberculosis during a 3-year period in the hospitals of Kerman, Iran. The expression level of the extracted miR-21 was analyzed using real-time polymerase chain reaction. Results: There was no significant difference in the serum miR-21 gene expression in the symptomatic patients with negative smear and negative purified protein derivative (PPD) skin test. However, the patients with positive smear and negative PPD, positive PPD and negative smear, and positive smear and positive PPD showed a significant increase in the miR21 gene expression (P<0.05). Conclusion: The obtained results confirmed the need for more accurate diagnostic methods, especially molecular techniques, for the detection of M. tuberculosis infection as late detection of infection can eliminate the possibility of effective treatment and endanger the lives of individuals. Due to the correlation between miR-21 and this infection, the miR-21 inhibitors can also be used for the treatment of the disease.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44807988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Eskandarloo, Karim Ghazikhanloo, Leyli Tapak, H. Sartipi
{"title":"Evaluation of Different Bone Types Prevalence on Implant Placement Site Using Cone Beam Computed Tomography Images","authors":"Amir Eskandarloo, Karim Ghazikhanloo, Leyli Tapak, H. Sartipi","doi":"10.29252/AJCM.27.3.164","DOIUrl":"https://doi.org/10.29252/AJCM.27.3.164","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48513110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vida Sheikh, Mirhamed Hoseini Aghdam, Mahdi Behzad
Background and Objective: The alterations of the adaptive immune system are involved in type 2 diabetes mellitus (T2DM) pathogenesis. T helper 1 (Th1) cells or CD4 T cells are the pro-inflammatory components of adaptive immunity with the main feature of interferon-gamma (IFN-γ) secretion. The aim of this study was to evaluate the percentage of IFN-γ, assess the expression of related-genes in CD4 T cells, including T-bet, IRF1, RUNX3, and NFκB, and determine the correlation between them and clinical parameters in T2DM patients. Materials and Methods: In this case-control study, peripheral blood CD4 T cells were isolated from 40 patients and 40 healthy controls (HCs). The percentage of IFN-γ secreting CD4 T cells was assessed using flow cytometry, and the related-genes were evaluated using real-time polymerase chain reaction. Results: The percentage of IFN-γ secreting CD4 T cells significantly increased in the patients in comparison to that of the HCs (P<0.001). The expression levels of IRF1 and NFκB were higher in the patients in comparison to those of the HCs (P=0.02 and P<0.001, respectively). A significant positive correlation between IFN-γ secreting CD4 T cells and both IRF1 and NFκB was observed in the patients (P=0.001 and P=0.002, respectively). There was a significant positive correlation between IFN-γ secreting CD4 T cells, IRF1, and NFκB with fasting plasma glucose and hemoglobin A1c in the patients (P<0.001). Conclusion: Due to the increased response of Th1 cells (the production of IFN-γ and expression of related genes) in the patients and existing correlation between them and plasma glucose level, it seems that these inflammatory factors are involved in T2DM pathogenesis, and the use of IFN-γ pathway antagonists could be considered a novel therapeutic approach.
{"title":"Evaluation of Percentage of Interferon-Gamma Secreting T Helper Cells and Expression of Related Genes in Patients with Type 2 Diabetes Mellitus","authors":"Vida Sheikh, Mirhamed Hoseini Aghdam, Mahdi Behzad","doi":"10.52547/ajcm.27.3.140","DOIUrl":"https://doi.org/10.52547/ajcm.27.3.140","url":null,"abstract":"Background and Objective: The alterations of the adaptive immune system are involved in type 2 diabetes mellitus (T2DM) pathogenesis. T helper 1 (Th1) cells or CD4 T cells are the pro-inflammatory components of adaptive immunity with the main feature of interferon-gamma (IFN-γ) secretion. The aim of this study was to evaluate the percentage of IFN-γ, assess the expression of related-genes in CD4 T cells, including T-bet, IRF1, RUNX3, and NFκB, and determine the correlation between them and clinical parameters in T2DM patients. Materials and Methods: In this case-control study, peripheral blood CD4 T cells were isolated from 40 patients and 40 healthy controls (HCs). The percentage of IFN-γ secreting CD4 T cells was assessed using flow cytometry, and the related-genes were evaluated using real-time polymerase chain reaction. Results: The percentage of IFN-γ secreting CD4 T cells significantly increased in the patients in comparison to that of the HCs (P<0.001). The expression levels of IRF1 and NFκB were higher in the patients in comparison to those of the HCs (P=0.02 and P<0.001, respectively). A significant positive correlation between IFN-γ secreting CD4 T cells and both IRF1 and NFκB was observed in the patients (P=0.001 and P=0.002, respectively). There was a significant positive correlation between IFN-γ secreting CD4 T cells, IRF1, and NFκB with fasting plasma glucose and hemoglobin A1c in the patients (P<0.001). Conclusion: Due to the increased response of Th1 cells (the production of IFN-γ and expression of related genes) in the patients and existing correlation between them and plasma glucose level, it seems that these inflammatory factors are involved in T2DM pathogenesis, and the use of IFN-γ pathway antagonists could be considered a novel therapeutic approach.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42337561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahnaz Yanangi, T. Artimani, Narges Sajedi, J. Poorolajal, Faranak Pour Monsef
Background and Objective: According to the results of some studies, peripheral blood mononuclear cells activated with human placental gonadotropin increase the success rate of pregnancy in infertile women. This study aimed to compare the effect of two treatment methods of peripheral blood mononuclear cells activated with human placental gonadotropin and platelet-rich plasma on the success rate of pregnancy after embryo transfer. Materials and Methods: This randomized clinical trial was conducted on 40 females with repeated implantation failure who were candidates for in vitro fertilization (IVF) and referred to Fatemieh Hospital, Hamadan, Iran, in 2019. Subsequently, they were randomly assigned to two groups of A and B. Peripheral blood mononuclear cells activated with human placental gonadotropin were utilized in group A, and group B received platelet -rich plasma autologous blood before transfusion. The incidence of chemical and clinical pregnancies was measured in both groups. Moreover, the data were analyzed in Stata software (version 14), and a p-value less than 0.05 was considered statistically significant. Results: The mean ages and duration of the infertility of the females were 32.5 and 34.4 years (P=0.203), as well as 9.1 and 8.5 years (P=0.747) in groups A and B, respectively. Moreover, the mean numbers of the obtained ovum, embryos formed, and transferred embryos were 15.4±11.5 and 12.9±8.9 (P=0.439), 7.1±6.2 and 5.8±3.8 (P=0.427), as well as 2.3±0.7 and 2.3±0.6 (P=1.00) in groups A and B, respectively. Furthermore, the rates of chemical pregnancies were 15% and 25% (P=0.619), and clinical pregnancies were 15% and 20% (P=0.581) in groups A and B, respectively. Conclusion: The administration of human placental gonadotropin-activated peripheral blood cells showed similar results on pregnancy outcome with platelet-rich plasma after an embryo transfer in females who were candidates for IVF with repeated implantation failure.
{"title":"Comparison of the Activated Peripheral Blood Mononuclear Cells with Human Placental Gonadotropin Method with Platelet-Rich Plasma on Pregnancy Success Rate after Embryo Transfer","authors":"Mahnaz Yanangi, T. Artimani, Narges Sajedi, J. Poorolajal, Faranak Pour Monsef","doi":"10.29252/AJCM.27.3.133","DOIUrl":"https://doi.org/10.29252/AJCM.27.3.133","url":null,"abstract":"Background and Objective: According to the results of some studies, peripheral blood mononuclear cells activated with human placental gonadotropin increase the success rate of pregnancy in infertile women. This study aimed to compare the effect of two treatment methods of peripheral blood mononuclear cells activated with human placental gonadotropin and platelet-rich plasma on the success rate of pregnancy after embryo transfer. Materials and Methods: This randomized clinical trial was conducted on 40 females with repeated implantation failure who were candidates for in vitro fertilization (IVF) and referred to Fatemieh Hospital, Hamadan, Iran, in 2019. Subsequently, they were randomly assigned to two groups of A and B. Peripheral blood mononuclear cells activated with human placental gonadotropin were utilized in group A, and group B received platelet -rich plasma autologous blood before transfusion. The incidence of chemical and clinical pregnancies was measured in both groups. Moreover, the data were analyzed in Stata software (version 14), and a p-value less than 0.05 was considered statistically significant. Results: The mean ages and duration of the infertility of the females were 32.5 and 34.4 years (P=0.203), as well as 9.1 and 8.5 years (P=0.747) in groups A and B, respectively. Moreover, the mean numbers of the obtained ovum, embryos formed, and transferred embryos were 15.4±11.5 and 12.9±8.9 (P=0.439), 7.1±6.2 and 5.8±3.8 (P=0.427), as well as 2.3±0.7 and 2.3±0.6 (P=1.00) in groups A and B, respectively. Furthermore, the rates of chemical pregnancies were 15% and 25% (P=0.619), and clinical pregnancies were 15% and 20% (P=0.581) in groups A and B, respectively. Conclusion: The administration of human placental gonadotropin-activated peripheral blood cells showed similar results on pregnancy outcome with platelet-rich plasma after an embryo transfer in females who were candidates for IVF with repeated implantation failure.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42309811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zahra Mortazavi, Seyed Sadegh Salehi sadati, M. Safari, N. Gohari, S. Mortazavi
{"title":"Investigation of Demographic Indicators of Phenylketonuria Patients and Determining the Reasons for Their Referral to Rehabilitation Centers","authors":"Zahra Mortazavi, Seyed Sadegh Salehi sadati, M. Safari, N. Gohari, S. Mortazavi","doi":"10.52547/ajcm.27.3.178","DOIUrl":"https://doi.org/10.52547/ajcm.27.3.178","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45110838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Manouchehrian, M. Davoudi, Mohammad Hossein Bkhshaei, N. Jiryaee, Azadeh Salehinejhad, M. Faryadras
{"title":"Evaluation of Leg Wrapping with Elastic Bandage for the Prevention of Post Spinal Hypotension in Cesarean Section","authors":"N. Manouchehrian, M. Davoudi, Mohammad Hossein Bkhshaei, N. Jiryaee, Azadeh Salehinejhad, M. Faryadras","doi":"10.21859/AJCM.27.2.69","DOIUrl":"https://doi.org/10.21859/AJCM.27.2.69","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41788521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Pregnancy Rate of Frozen Embryos by Two Methods: Long with GnRH Agonist and OCP with Estradiol Only","authors":"S. Rabiei, Mohammad Fallah, F. Jamshidi","doi":"10.29252/AJCM.27.1.5","DOIUrl":"https://doi.org/10.29252/AJCM.27.1.5","url":null,"abstract":"","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48737656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nasim Baniasadi, A. Kariminik, Sayed Mohammad Reza Khoshroo
Background and Objective: Due to the increased prevalence of microbial resistance against chemical antimicrobial agents, the biological effects of metallic nanoparticles have recently been studied by researchers. In this regard, the present study aimed to investigate the antimicrobial effects of iron oxide nanoparticles made by chemical methods in different concentrations on bacteria isolated from urinary tract infections. Materials and Methods: In this descriptive cross-sectional research, iron oxide nanoparticles were synthesized by chemical precipitation method using chemical reactants and only by controlling the conditions and applying optimal conditions. Subsequently, their bactericidal effects on the six common bacteria causing urinary tract infections was studied using agar well diffusion method. The minimum inhibitory and bactericidal concentrations of nanoparticles were determined as well. In addition, the antibiotic resistance pattern of bacteria was investigated for antibiotics Gentamycin, amikacin, ampicillin, nalidixic acid, ciprofloxacin, norfloxacin, sulfamethoxazole using disk diffusion method. Results: The iron oxide nanoparticle was made in a spherical shape with a diameter of approximately 60 nm. Bacteria had an extensive antibiotic resistance, but iron nanoparticles were effective on all 6 bacteria, and the minimum inhibitory and bactericidal concentration to Proteus mirabilis, Klebsiella pneumoniae, staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Serratia marcescens were 0.32, 0.04, 0.02, 0.08, 0.04, and 0.02 at 1.25, 0.08, 0.61, 32 0, 16.0, and 16.0 mg/mL
{"title":"Synthesis and Study of Bactericidal Effects of Iron Oxide Nanoparticles on Bacteria Isolated from Urinary Tract Infections","authors":"Nasim Baniasadi, A. Kariminik, Sayed Mohammad Reza Khoshroo","doi":"10.29252/AJCM.27.1.37","DOIUrl":"https://doi.org/10.29252/AJCM.27.1.37","url":null,"abstract":"Background and Objective: Due to the increased prevalence of microbial resistance against chemical antimicrobial agents, the biological effects of metallic nanoparticles have recently been studied by researchers. In this regard, the present study aimed to investigate the antimicrobial effects of iron oxide nanoparticles made by chemical methods in different concentrations on bacteria isolated from urinary tract infections. Materials and Methods: In this descriptive cross-sectional research, iron oxide nanoparticles were synthesized by chemical precipitation method using chemical reactants and only by controlling the conditions and applying optimal conditions. Subsequently, their bactericidal effects on the six common bacteria causing urinary tract infections was studied using agar well diffusion method. The minimum inhibitory and bactericidal concentrations of nanoparticles were determined as well. In addition, the antibiotic resistance pattern of bacteria was investigated for antibiotics Gentamycin, amikacin, ampicillin, nalidixic acid, ciprofloxacin, norfloxacin, sulfamethoxazole using disk diffusion method. Results: The iron oxide nanoparticle was made in a spherical shape with a diameter of approximately 60 nm. Bacteria had an extensive antibiotic resistance, but iron nanoparticles were effective on all 6 bacteria, and the minimum inhibitory and bactericidal concentration to Proteus mirabilis, Klebsiella pneumoniae, staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Serratia marcescens were 0.32, 0.04, 0.02, 0.08, 0.04, and 0.02 at 1.25, 0.08, 0.61, 32 0, 16.0, and 16.0 mg/mL","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45105739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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