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Neonatal Brain Magnetic Resonance Imaging Findings and Its Relationship with Demographic Characteristics of Neonates 新生儿脑磁共振成像结果及其与新生儿人口学特征的关系
Q4 Medicine Pub Date : 2019-09-01 DOI: 10.21859/AJCM.26.2.118
Ahmad Rezaee Azandariani, Masoud Esnaashari, Fahimeh Maghsoodi, F. Esna-Ashari
Background and Objective: Neonatal neurological diseases are characterized by a range of clinical symptoms and signs that can be confirmed by Magnetic Resonance Imaging (MRI) in some cases. This study aimed to examine the neonatal cerebral MRI descriptively. Materials and Methods: In this comparative cross-sectional study, 69 MRI neonatal images were analyzed from January to April 2019. These images were extracted from the archives of the MRI Center affiliated to Besat Hospital, Hamadan, Iran. Moreover, demographic characteristics of the infants, including age, gender, birth rank, consanguineous marriage among their parents, as well as initial and final diagnosis were extracted and analyzed in this study. Results: According to the results, 65.4% of the infants were male, and the mean age of the neonates was obtained at 13±9.9 days. The initial and final diagnoses confirmed the seizure in most cases. In general, the MRI results were completely normal in 60.9% of the neonates. There was no significant relationship between the variables studied and abnormal MRI results in the
背景与目的:新生儿神经系统疾病以一系列临床症状和体征为特征,在某些情况下可以通过磁共振成像(MRI)进行确认。本研究旨在对新生儿大脑MRI进行描述性检查。材料和方法:在这项比较横断面研究中,分析了2019年1月至4月的69张新生儿MRI图像。这些图像是从伊朗哈马丹贝萨特医院附属MRI中心的档案中提取的。此外,本研究还提取并分析了婴儿的人口统计学特征,包括年龄、性别、出生等级、父母之间的血亲关系以及最初和最终诊断。结果:根据结果,65.4%的婴儿是男性,新生儿的平均年龄为13±9.9天。在大多数情况下,最初和最终的诊断都证实了癫痫发作。总的来说,60.9%的新生儿的MRI结果完全正常。研究的变量与患者的异常MRI结果之间没有显著关系
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引用次数: 0
Seroepidemiology of Toxocariasis in 2-12-year-old Children Refered to Health Centers in Kermanshah during 2018 Kermanshah卫生中心2018年2-12岁儿童弓形虫病的血清流行病学
Q4 Medicine Pub Date : 2019-09-01 DOI: 10.21859/AJCM.26.2.99
S. Mansouri, M. Fallah, Amirhoseein Maghsood, M. Matini
Background and Objective: Toxocariasis is a common infection between humans and animals, which can be considered as a health issue in vulnerable populations due to its indigenous nature to the country and the region. Therefore, the purpose of this study was to estimate the risk of contamination with Toxocara canis infection and exposure to its parasite in children. Materials and Methods: This descriptive cross-sectional study was performed on 621 children aged 2 to12 years referred to health centers in Kermanshah, Iran. After sampling and recording the demographic characteristics, the samples were tested for anti-T. canis antibody (IgG) by enzyme-linked immunosorbent assay method. Data analysis was done using SPSS software and Fisher's exact test. Results: Out of 621 tested serum samples, 8 samples (1.3%) were positive for anti-Toxocara IgG antibodies. Of these, 5 and 3 samples were from male and female patients all living in urban areas. It is noteworthy that none of these individuals had a history of earth-eating, as well as touching or playing with the dog. However, a dog was kept at one of the child's home. Conclusion: The results of the study showed a relatively low prevalence of toxocariasis infection in children, although the findings confirmed the establishment of the parasite transmission cycle in the region. Therefore, considering the importance of hygiene issues, it is necessary to develop and implement strategies for controlling and preventing the infection in the definitive hosts of the parasite in order to reduce the incidence of human
背景和目的:弓形虫病是一种常见的人与动物之间的感染,由于其在国家和区域的地方性,可被视为脆弱人群的健康问题。因此,本研究的目的是估计儿童感染犬弓形虫和暴露于其寄生虫的污染风险。材料和方法:本描述性横断面研究在伊朗Kermanshah的卫生中心对621名2至12岁的儿童进行了研究。在抽样和记录人口统计学特征后,对样本进行抗t检测。酶联免疫吸附法测定犬抗体(IgG)。数据分析采用SPSS软件和Fisher精确检验。结果:621份血清样本中,8份(1.3%)血清抗弓形虫IgG抗体阳性。其中,5个样本来自城市地区的男性和3个样本来自女性患者。值得注意的是,这些人都没有吃土的历史,也没有触摸或与狗玩耍的历史。然而,其中一个孩子的家里养了一只狗。结论:研究结果显示,儿童弓形虫病感染率相对较低,尽管研究结果证实了该地区寄生虫传播周期的建立。因此,考虑到卫生问题的重要性,有必要制定和实施控制和预防寄生虫最终宿主感染的策略,以减少人类的发病率
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引用次数: 0
Clinical and Para Clinical Manifestations of HIV-Positive Patients at Different Levels of CD4 不同CD4水平hiv阳性患者的临床及准临床表现
Q4 Medicine Pub Date : 2019-09-01 DOI: 10.21859/AJCM.26.2.110
F. Keramat, Parisa Hamzeloui, M. Rabiei, A. Saadatmand
Background and Objective: Human immunodeficiency virus (HIV)infected people are at higher risk of opportunistic infections due to immunodeficiency. The current study aimed to evaluate the different levels of CD4 in HIV-infected patients and its relationship with clinical and paraclinical manifestations of the patients. Materials and Methods: This cross-sectional study was conducted on 94 HIV-infected patients referred to the Counseling Centers for Behavioral Diseases and Sina Hospital in Hamadan, from 2014 to 2015. At the commencement of the study, written consent was obtained from the participants. Thereafter, demographic data, history of underlying diseases, symptoms and clinical syndromes, medical history, and serum CD4 levels were evaluated by flow cytometric recorded in the questionnaire and data were analyzed in SPSS software(version 16). Results: Out of 66 HIV-positive patients, 70.2% (n=38) were male and the mean age of the patients was 40.06±10. 04 years. In terms of classification of the clinical stage of the disease, the patinets in the first, second, and third stages were reported as 11 (11.7%), 36 (38.3%) and 34 (36.2%), respectively. The mean serum CD4 count of the patients at the beginning of antiretroviral therapy was measured at 284.241±284 and 377.19±271.41 cells /μl, respectively. The difference in the mean of serum CD4 count before and after antiretroviral therapy was revealed to be statistically significant (P=0.001). The most common clinical symptoms observed included cough and sputum (29.9%), oral aphthous ulcer (12.7%), weight loss (11.7%), and fever (7.4%). Based on the results of the study, there was a significant difference between the mean of platelet count, hemoglobin and alkaline phosphatase at different levels of CD4 (P<0.05). Conclusion: According to the results of the present study, serum CD4 levels rise with the initiation of antiretroviral therapy in HIV infected patients; therefore, early antiretroviral therapy in HIV-infected patients with any serum CD4 level is of paramount importance.
背景与目的:人类免疫缺陷病毒(HIV)感染者由于免疫缺陷导致机会性感染的风险较高。本研究旨在探讨hiv感染患者体内CD4的不同水平及其与患者临床和临床旁表现的关系。材料与方法:对2014 - 2015年在哈马丹行为疾病咨询中心和新浪医院就诊的94例hiv感染者进行横断面研究。在研究开始时,获得了参与者的书面同意。随后,通过流式细胞术评估问卷中记录的人口统计学资料、基础疾病史、症状及临床综合征、病史、血清CD4水平,并用SPSS (version 16)软件对数据进行分析。结果:66例hiv阳性患者中,男性38例,占70.2%,平均年龄40.06±10岁。04年。在临床分期方面,第一、第二、第三期患者分别为11例(11.7%)、36例(38.3%)和34例(36.2%)。患者在抗逆转录病毒治疗开始时的平均血清CD4计数分别为284.241±284和377.19±271.41细胞/μl。抗逆转录病毒治疗前后血清CD4计数平均值的差异有统计学意义(P=0.001)。最常见的临床症状包括咳痰(29.9%)、口腔溃疡(12.7%)、体重减轻(11.7%)和发烧(7.4%)。本研究结果显示,不同CD4水平下患者血小板计数、血红蛋白、碱性磷酸酶均值差异有统计学意义(P<0.05)。结论:根据本研究结果,HIV感染者血清CD4水平随着抗逆转录病毒治疗的开始而升高;因此,在任何血清CD4水平的hiv感染者中,早期抗逆转录病毒治疗都是至关重要的。
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引用次数: 0
Frequency and Risk Factors of Retinopathy of Prematurity in Newborns Admitted to Neonatal Intensive Care Unit in Hamadan 哈马丹新生儿重症监护室新生儿早产视网膜病变的发生率及危险因素
Q4 Medicine Pub Date : 2019-06-15 DOI: 10.29252/AJCM.26.1.44
B. Basiri, M. Sabzehei, M. Solgi, S. Akbarzadeh, Somaye Ivazeh
Background and Objective: Retinopathy of prematurity (ROP) is an evolutionary disorder in the retina of premature infants. Nowadays, the prevalence rate of retinopathy has increased due to the advancement of medical facilities and the increased survival of preterm infants. The aim of this study was to determine the prevalence rate of ROP and its related risk factors among infants admitted to and examined at neonatal intensive care unit (NICU) affiliated to Fatemieh Hospital in Hamadan. Materials and Methods: This descriptive cross-sectional study was conducted on all premature infants selected with census sampling methods and with a gestational age of fewer than 34 weeks who were hospitalized in NICU for four weeks or more. The premature infants were investigated regarding the incidence of retinopathy and its risk factors. Results: Out of 80 neonates under study, 24 (30%) cases suffered from ROP, of which 16 and 8 neonates were in stage I and II of ROP, respectively. Moreover, the mean gestational age of newborns was 29.71±2.16 weeks, and more than 75% of ROP were observed in neonates under 29 weeks' gestational age. In addition, the results revealed that ROP correlated significantly with gestational age, low birth weight, 1 and 5 minute Apgar scores, the need to resuscitation, the use of inotropic drugs, and duration of oxygen therapy. However, there was a significant relationship between low birth weight and retinopathy based on the results obtained from logistic
背景与目的:早产儿视网膜病变(Retinopathy of prematurity, ROP)是早产儿视网膜的一种进化性疾病。如今,由于医疗设施的进步和早产儿存活率的增加,视网膜病变的患病率有所增加。本研究的目的是确定在哈马丹Fatemieh医院附属新生儿重症监护病房(NICU)住院和检查的婴儿中ROP的患病率及其相关危险因素。材料和方法:本描述性横断面研究采用人口普查抽样方法选取胎龄小于34周且在NICU住院4周及以上的所有早产儿。对早产儿视网膜病变的发生率及其危险因素进行调查。结果:80例新生儿中有24例(30%)发生ROP,其中16例为I期,8例为II期。平均胎龄为29.71±2.16周,29周以下的新生儿发生ROP的比例超过75%。此外,结果显示,ROP与胎龄、低出生体重、1分钟和5分钟Apgar评分、复苏需要、使用肌力药物和氧疗持续时间显著相关。然而,根据logistic分析结果,低出生体重与视网膜病变之间存在显著关系
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引用次数: 2
Impact of Mild Hypothermia on the Recovery of Patients with Acute Stroke 亚低温对急性脑卒中患者康复的影响
Q4 Medicine Pub Date : 2019-06-15 DOI: 10.29252/AJCM.26.1.26
A. Rozbahani, M. Rezaee, M. Khazaei
Background and Objective: Hypothermia induction has been proposed to improve the recovery process of stroke in the last two decades. Therefore, the aim of this study was to investigate the effect of mild hypothermia on the recovery of patients with acute stroke. Materials and Methods: This single-blind randomized clinical trial was conducted on 60 patients with acute stroke in 2018 in Hamadan, Iran. The patients were selected by available sampling method, and then randomly assigned into two equal-sized groups of intervention and control. Mild hypothermia was induced using a cooling device applied on the patients' head for a period of 72 h. The National Institutes of Health Stroke Scale (NIHSS) was used to collect the data. The results of both groups were compared with each other following the intervention. Finally, the data were analyzed using SPSS software (version 22). Results: The results showed no significant difference between the mean scores obtained before and after the intervention in the control group (P>0.05). In addition, there was no significant difference between the intervention and control groups in terms of the pre-intervention mean scores (P>0.05). However, the results revealed a statistically significant difference in the mean preand post-intervention scores of the intervention group (P<0.05). In this regard, the mean score of NIHSS was significantly reduced in the intervention group after the induction of hypothermia. Finally, the results were indicative of a statistically significant difference between the intervention and control groups after the intervention (P<0.05). Conclusion: As the findings of the present study indicated, noninvasively induced hypothermia has a significant clinical effect on acute stroke. Therefore, it can be argued that the use of hypothermia leads to the enhancement of consciousness level and reduction of mortality risk in patients with acute stroke. Consequently, this intervention is suggested to be considered the main therapeutic approach of acute stroke.
背景与目的:近二十年来,低温诱导已被提出用于改善脑卒中患者的恢复过程。因此,本研究的目的是探讨亚低温对急性脑卒中患者康复的影响。材料与方法:该单盲随机临床试验于2018年在伊朗哈马丹对60例急性脑卒中患者进行了研究。采用有效的抽样方法,将患者随机分为干预组和对照组。在患者头部应用冷却装置诱导轻度低温72小时。采用美国国立卫生研究院卒中量表(NIHSS)收集数据。干预后,对两组结果进行比较。最后,使用SPSS (version 22)软件对数据进行分析。结果:对照组干预前后平均得分差异无统计学意义(P < 0.05)。干预组与对照组干预前平均评分差异无统计学意义(P < 0.05)。但结果显示,干预组干预前后平均评分差异有统计学意义(P<0.05)。因此,干预组诱导低温后NIHSS平均评分明显降低。最后,干预组与对照组干预后差异有统计学意义(P<0.05)。结论:本研究结果表明,无创低温治疗急性脑卒中具有显著的临床效果。因此,可以认为,使用低温可以提高急性脑卒中患者的意识水平,降低死亡风险。因此,这种干预被认为是急性脑卒中的主要治疗方法。
{"title":"Impact of Mild Hypothermia on the Recovery of Patients with Acute Stroke","authors":"A. Rozbahani, M. Rezaee, M. Khazaei","doi":"10.29252/AJCM.26.1.26","DOIUrl":"https://doi.org/10.29252/AJCM.26.1.26","url":null,"abstract":"Background and Objective: Hypothermia induction has been proposed to improve the recovery process of stroke in the last two decades. Therefore, the aim of this study was to investigate the effect of mild hypothermia on the recovery of patients with acute stroke. Materials and Methods: This single-blind randomized clinical trial was conducted on 60 patients with acute stroke in 2018 in Hamadan, Iran. The patients were selected by available sampling method, and then randomly assigned into two equal-sized groups of intervention and control. Mild hypothermia was induced using a cooling device applied on the patients' head for a period of 72 h. The National Institutes of Health Stroke Scale (NIHSS) was used to collect the data. The results of both groups were compared with each other following the intervention. Finally, the data were analyzed using SPSS software (version 22). Results: The results showed no significant difference between the mean scores obtained before and after the intervention in the control group (P>0.05). In addition, there was no significant difference between the intervention and control groups in terms of the pre-intervention mean scores (P>0.05). However, the results revealed a statistically significant difference in the mean preand post-intervention scores of the intervention group (P<0.05). In this regard, the mean score of NIHSS was significantly reduced in the intervention group after the induction of hypothermia. Finally, the results were indicative of a statistically significant difference between the intervention and control groups after the intervention (P<0.05). Conclusion: As the findings of the present study indicated, noninvasively induced hypothermia has a significant clinical effect on acute stroke. Therefore, it can be argued that the use of hypothermia leads to the enhancement of consciousness level and reduction of mortality risk in patients with acute stroke. Consequently, this intervention is suggested to be considered the main therapeutic approach of acute stroke.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69850995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between rs2735839 and Serum Prostate-specific Antigen Level Regarding Risk of Prostate Cancer in Iranian Population rs2735839与伊朗人群前列腺特异性抗原水平与前列腺癌症风险的相关性
Q4 Medicine Pub Date : 2019-06-01 DOI: 10.21859/AJCM.26.1.12
B. Beikzadeh, S. Angaji, M. Abolhasani
Background and Objective: Prostate cancer is among the five common cancers in males. It is second cancer in terms of the age-standardized rate (ASR) (ASR=16.6) in Iran. The rs2735839 G/A, an intergenic polymorphism is located on chromosome 19q13.33 at 600 base pairs of the KLK3 gene untranslatable region. This gene which codes prostate-specific antigen (PSA) is used in the screening and diagnosis of prostate cancer. The purpose of this study was to evaluate the association between this polymorphism and prostate adenocarcinoma with PSA. Materials and Methods: This case-control study included 103 and 100 patients with prostate adenocarcinoma and benign prostatic hyperplasia (BPH) as case and control groups, respectively. Tetra-primer amplification refractory mutation system-polymerase chain reaction was used to determine the genotype of each participant regarding rs2735839 polymorphism. Results: There was a significant difference between the adenocarcinoma prostate and BPH groups regarding genotype frequency AG+AA (OR [95% CI]=4.991 [2.475-10.065], P=0.00). According to the results of statistical analysis, a significant difference was observed between the adenocarcinoma and BPH groups in terms of allele frequency (OR [95% CI]=3.927 [2.0857.397], P=0.00). Moreover, There was a significant difference between rs2735839 and PSA regarding the genotype frequency polymorphism (P=0.011). Conclusion: The results indicate that rs2735839 is associated with an increased risk of prostate cancer in Iranian population. It is worth noting that a significant difference was found between the distribution of allele A and that of allele G with PSA levels of >10.
背景与目的:前列腺癌是男性常见的五种癌症之一。就年龄标准化率(ASR)而言,它是伊朗第二大癌症(ASR=16.6)。rs2735839 G/A是一种基因间多态性,位于染色体19q13.33上KLK3基因不可翻译区600个碱基对处。该基因编码前列腺特异性抗原(PSA),用于前列腺癌的筛查和诊断。本研究的目的是评估这种多态性与PSA前列腺腺癌之间的关系。材料与方法:本病例对照研究选取103例前列腺癌和100例良性前列腺增生(BPH)患者作为病例组和对照组。采用四引物扩增难解突变系统聚合酶链反应测定每位受试者rs2735839多态性基因型。结果:前列腺腺癌组与BPH组基因型频率AG+AA差异有统计学意义(OR [95% CI]=4.991 [2.475 ~ 10.065], P=0.00)。统计分析结果显示,腺癌组与BPH组等位基因频率差异有统计学意义(OR [95% CI]=3.927 [2.0857.397], P=0.00)。rs2735839与PSA基因型频率多态性差异有统计学意义(P=0.011)。结论:rs2735839基因与伊朗人群前列腺癌发病风险增加有关。值得注意的是,当PSA水平为bbbb10时,等位基因a和等位基因G的分布存在显著差异。
{"title":"Association between rs2735839 and Serum Prostate-specific Antigen Level Regarding Risk of Prostate Cancer in Iranian Population","authors":"B. Beikzadeh, S. Angaji, M. Abolhasani","doi":"10.21859/AJCM.26.1.12","DOIUrl":"https://doi.org/10.21859/AJCM.26.1.12","url":null,"abstract":"Background and Objective: Prostate cancer is among the five common cancers in males. It is second cancer in terms of the age-standardized rate (ASR) (ASR=16.6) in Iran. The rs2735839 G/A, an intergenic polymorphism is located on chromosome 19q13.33 at 600 base pairs of the KLK3 gene untranslatable region. This gene which codes prostate-specific antigen (PSA) is used in the screening and diagnosis of prostate cancer. The purpose of this study was to evaluate the association between this polymorphism and prostate adenocarcinoma with PSA. Materials and Methods: This case-control study included 103 and 100 patients with prostate adenocarcinoma and benign prostatic hyperplasia (BPH) as case and control groups, respectively. Tetra-primer amplification refractory mutation system-polymerase chain reaction was used to determine the genotype of each participant regarding rs2735839 polymorphism. Results: There was a significant difference between the adenocarcinoma prostate and BPH groups regarding genotype frequency AG+AA (OR [95% CI]=4.991 [2.475-10.065], P=0.00). According to the results of statistical analysis, a significant difference was observed between the adenocarcinoma and BPH groups in terms of allele frequency (OR [95% CI]=3.927 [2.0857.397], P=0.00). Moreover, There was a significant difference between rs2735839 and PSA regarding the genotype frequency polymorphism (P=0.011). Conclusion: The results indicate that rs2735839 is associated with an increased risk of prostate cancer in Iranian population. It is worth noting that a significant difference was found between the distribution of allele A and that of allele G with PSA levels of >10.","PeriodicalId":52678,"journal":{"name":"pzshkhy blyny bn syn","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41833033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the Moderating Role of Perceived Vulnerability to Infectious Diseases Regarding the Relationship between Disgust and Fear of Contamination 传染病易感性在厌恶与污染恐惧关系中的调节作用研究
Q4 Medicine Pub Date : 2019-06-01 DOI: 10.21859/AJCM.26.1.34
Mona Moradi Motlagh, M. Nainian, L. Fata, M. Fesharaki, G. Ghaedi
Background and Objective: Several studies revealed that disgust as an emotional response underlies the contamination fears in Contamination Obsessive Compulsive Disorder (OCD). Other studies supported the role of cognitions related to contagion and disease in contamination OCD. The present study aimed to integrate these two lines of evidence. To this end, regarding the concept of the behavioral immune system, it was investigated whether perceived vulnerability to infectious disease, as a cognitive component of the behavioral immune system, can moderate the relation between disgust, as the emotional component of this system, and symptoms of contamination OCD. Materials and Methods: This cross-sectional study was conducted on 350 university students in Tehran University through cluster random sampling. The participants were asked to complete the Persian version of the disgust scale, perceived vulnerability to disease questionnaire, and Vancouver contamination subscale. The data were analyzed utilizing hierarchical regression analysis and post hoc tests. Results: The results revealed that perceived vulnerability to infectious disease moderated the relationship between the feeling of disgust and fear of contamination. According to the results, perceived infectability subscale which measures perceived weakness of one's immune system with more accuracy, can also exacerbate the relationship between the feeling of disgust and fear of contamination. Conclusion: The results of this study facilitate the understanding of the effect of disgust on fear of contamination, especially the role of cognitions about contagion and disease in potentiating the relation between disgust and contamination OCD. Moreover the obtained results generally provide evidence for the disease-avoidance theory in disgust and support the possible hyperactivity of the behavioral immune system in contamination OCD.
背景和目的:几项研究表明,厌恶作为一种情绪反应,是污染强迫症(OCD)中污染恐惧的基础。其他研究支持与传染和疾病相关的认知在污染强迫症中的作用。本研究旨在整合这两条证据线。为此,关于行为免疫系统的概念,研究了作为行为免疫系统认知组成部分的对传染病的感知脆弱性是否可以调节作为该系统情感组成部分的厌恶与污染强迫症症状之间的关系。材料和方法:本研究采用整群随机抽样的方法,对德黑兰大学350名大学生进行了横断面研究。参与者被要求完成波斯版的厌恶量表、对疾病的感知脆弱性问卷和温哥华污染分量表。利用层次回归分析和事后检验对数据进行分析。结果:研究结果表明,对传染病的易感性调节了厌恶感和对污染的恐惧感之间的关系。根据研究结果,感知可感染性分量表更准确地衡量一个人免疫系统的感知弱点,也会加剧厌恶感和对污染的恐惧之间的关系。结论:本研究的结果有助于理解厌恶对污染恐惧的影响,特别是对传染病和疾病的认知在增强厌恶与污染强迫症之间关系中的作用。此外,所获得的结果通常为厌恶中的疾病回避理论提供了证据,并支持污染强迫症中行为免疫系统可能的过度活跃。
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引用次数: 0
Evaluation of the Frequency of Risk Factors in Venous Thromboembolic Patients Admitted to Ekbatan and Farshchian Hospitals in Hamadan from 2012 to 2017 2012 - 2017年哈马丹市Ekbatan和Farshchian医院静脉血栓栓塞患者危险因素频率评估
Q4 Medicine Pub Date : 2019-06-01 DOI: 10.21859/AJCM.26.1.60
F. Fariba, N. Jiryaee, Chonoor Neshatyar, Masoud Tarbiat
Background and Objective: Venous thromboembolism is one of the major causes of mortality worldwide. Various environmental and genetic factors are known as risk factors for this disease. Therefore, this study aimed to investigate the frequency of risk factors in patients with venous thromboembolism admitted to Ekbatan and Farshchian hospitals in Hamadan from 2012 to 2017. Materials and Methods: This cross-sectional descriptive study investigated all patients with venous thromboembolism who had medical records regarding risk factors of venous thromboembolism using census sampling method. The obtained data were analyzed in SPSS software (Version 21). Results: According to the results, out of 226 patients under study, 116 (51.3%) ones were male. Moreover, 103 (45.6%), 76 (33.6%), and 47 (20.8%) patients had deep venous thrombosis, pulmonary embolism, and severe lung embolism with deep venous thrombosis, respectively. The mean±SD age of patients was 59.15±19.85 years. Moreover, the most frequent risk factors associated with venous thromboembolism include the history of hypertension (37.2%), recent hospitalization (29.6%), cardiovascular problems (27.5%), history of recent surgery (16.8%), history of intravenous thromboembolism (8.8% 16%), history of smoking (16.8%), statin use (15.5%), history of hyperlipidemia (13.7%), and catheterization
背景与目的:静脉血栓栓塞是世界范围内死亡的主要原因之一。各种环境和遗传因素被认为是这种疾病的危险因素。因此,本研究旨在调查2012年至2017年在哈马丹Ekbatan和Farshchian医院住院的静脉血栓栓塞患者危险因素的频率。材料和方法:本横断面描述性研究采用人口普查抽样方法调查了所有有静脉血栓栓塞危险因素医疗记录的静脉血栓栓塞患者。所得数据在SPSS软件(Version 21)中进行分析。结果:226例患者中,男性116例(51.3%)。深静脉血栓103例(45.6%),肺栓塞76例(33.6%),重度肺栓塞合并深静脉血栓47例(20.8%)。患者平均±SD年龄为59.15±19.85岁。此外,与静脉血栓栓塞相关的最常见危险因素包括高血压史(37.2%)、近期住院史(29.6%)、心血管问题(27.5%)、近期手术史(16.8%)、静脉血栓栓塞史(8.8%)、吸烟史(16.8%)、他汀类药物使用史(15.5%)、高脂血症史(13.7%)和导管置入术
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引用次数: 1
Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes 加巴喷丁与月见草油治疗2型糖尿病周围神经病变疼痛的疗效比较
Q4 Medicine Pub Date : 2019-06-01 DOI: 10.29252/ajcm.26.1.5
Zohreh Nasrabadi, M. Rakhshani, Hooman Ebadi, R. Akbarzadeh
Background and Objective: Neuropathic pain is one of the common, important, and irritating complications in diabetes. Despite the importance of this pain, there is still no effective treatment for that. The aim of this study was to determine the effect of evening primrose oil and gabapentin on neuropathic pain in patients with type 2 diabetes. Materials and Methods: This triple-blind clinical trial was performed on 70 patients with diabetic neuropathy who obtained score 2 from the Michigan Questionnaire and referred to the Department of Endocrinology at Khayyam clinic affiliated to Hakim Hospital in Neyshabour from December 2017 to May 2018. The participants were divided into two groups of 35 people. The intervention group was treated with a capsule of evening primrose oil orally (1000 mg) twice daily for three months and gabapentin (300 mg) daily. On the other hand, the control group was treated with gabapentin (300 mg) and placebo. The neuropathy pain severity was measured before and after the end of three-month intervention using Michigan and McGill Pain Questionnaires. Data analysis was performed in SPSS software (version 21) through Fisher's exact test, ANCOVA, multilevel logistic regression, Mann Whitney U test, Kolmogorov-Smirnov test, and the Chi-square tests. P-value less than 0.05 was considered statistically significant. Results: According to the results obtained from the McGill questionnaire, the mean scores of neuropathy before the intervention were obtained at 10.12±0.57 and 9.85±0.65 in the intervention and control groups, respectively. However, the mean scores of neuropathy after the intervention were estimated at 6.18±0.48 and 8.31±0.60 in the intervention and control groups, respectively, which was statistically significant (P<0.02). Conclusion: Evening primrose oil is effective in reducing neuropathic pain in type 2 diabetic patients. Therefore, this can be a supplementary treatment for reducing pain associated with diabetic neuropathy.
背景与目的:神经性疼痛是糖尿病常见、重要、刺激的并发症之一。尽管这种疼痛很重要,但仍然没有有效的治疗方法。本研究的目的是确定月见草油和加巴喷丁对2型糖尿病患者神经性疼痛的影响。材料与方法:本三盲临床试验于2017年12月至2018年5月在Neyshabour Hakim医院附属Khayyam诊所内分泌科就诊的70例密歇根问卷评分为2分的糖尿病性神经病变患者进行。参与者被分成两组,每组35人。干预组给予月见草油胶囊(1000 mg)口服,每日2次,连用3个月;加巴喷丁(300 mg)每日服用。另一方面,对照组给予加巴喷丁(300 mg)和安慰剂治疗。采用密歇根疼痛问卷和麦吉尔疼痛问卷,在三个月干预结束前后测量神经性疼痛严重程度。采用SPSS软件(version 21)进行数据分析,采用Fisher精确检验、ANCOVA、多水平logistic回归、Mann Whitney U检验、Kolmogorov-Smirnov检验和卡方检验。p值小于0.05认为有统计学意义。结果:根据McGill问卷调查结果,干预组和对照组干预前神经病变平均评分分别为10.12±0.57分和9.85±0.65分。干预组与对照组神经病变平均评分分别为6.18±0.48分、8.31±0.60分,差异有统计学意义(P<0.02)。结论:月见草油能有效减轻2型糖尿病患者的神经性疼痛。因此,这可以作为减轻糖尿病神经病变相关疼痛的辅助治疗。
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引用次数: 2
Comparison of Cytologic Reports of Fine-Needle Aspiration of Thyroid Nodules with Pathologic Results of Thyroid Surgery 细针穿刺甲状腺结节的细胞学报告与甲状腺手术病理结果的比较
Q4 Medicine Pub Date : 2019-06-01 DOI: 10.29252/AJCM.26.1.20
A. Jafari, A. Dehghan, F. Esna-Ashari, S. Borzouei
Background and Objective: Thyroid nodules are among the most common clinical problems and the application of an inexpensive and accurate diagnostic method prevents performing inessential surgeries. In this regard, the aim of this study was to compare the cytologic report of fine-needle aspiration (FNA) of thyroid nodules with the results of thyroid surgery. Materials and Methods: In this cross-sectional study, all the patients who had referred to the clinic of Beheshti Hospital of Hamedan, Iran, due to thyroid nodule in 2017 underwent FNA. The samples were then sent to the pathology laboratory, and the cytology results were recorded in a checklist. Based on the cytology results, a portion of these cases was referred to undergo surgery. Following that, the sensitivity and specificity of cytology results of thyroid nodules were calculated in comparison to pathology results of the surgery sample. Results: Out of 115 studied patients, 18 (15.65%) and 97 (84.35%) subjects were male and female, respectively. The mean age of the subjects was 40.14±12.34 years. Most cases were in the form of the right-side unilateral nodule (46.1%). The number of benign and malignant cases diagnosed by the pathologist was 73 (63.48%) and 42 (36.52%), respectively. The specificity, sensitivity, as well as positive and negative predictive values obtained from the FNA of thyroid nodules by the pathologist, were reported as 82.98%, 95.56%, 89.04, and 92.68%, respectively. It is necessary to mention that the diagnostics accuracy of the pathologist associated with the results of surgery pathology was 90.43%. Conclusion: Performing FNA enjoys a relatively high specificity and sensitivity as an inexpensive, low-risk, and simple method in the differentiation of benign and malignant cases if it is performed precisely from the site of the nodule with adequate biopsy and properly examined
背景与目的:甲状腺结节是最常见的临床问题之一,应用廉价而准确的诊断方法可以避免不必要的手术。在这方面,本研究的目的是比较细针穿刺(FNA)甲状腺结节的细胞学报告与甲状腺手术的结果。材料与方法:在本横断面研究中,2017年因甲状腺结节转诊至伊朗Hamedan Beheshti医院门诊的所有患者均行FNA。然后将样本送到病理实验室,细胞学结果记录在检查表中。根据细胞学结果,这些病例中的一部分被转介接受手术。然后计算甲状腺结节细胞学结果与手术标本病理结果的敏感性和特异性。结果:115例患者中,男性18例(15.65%),女性97例(84.35%)。患者平均年龄40.14±12.34岁。以右侧单侧结节为主(46.1%)。病理诊断良性73例(63.48%),恶性42例(36.52%)。病理学家FNA对甲状腺结节的特异性、敏感性及阳性预测值和阴性预测值分别为82.98%、95.56%、89.04和92.68%。需要提及的是,与手术病理结果相关的病理学家诊断准确率为90.43%。结论:准确从结节部位行FNA,活检充分,检查得当,具有较高的特异性和敏感性,是一种廉价、低风险、简便的良恶性鉴别方法
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引用次数: 0
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pzshkhy blyny bn syn
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