Journal of Affective Disorders Reports最新文献

Does rTMS modulate phenotype of microglia in patients with treatment-resistant depression? A transcriptome analysis using iMG cells

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-22 DOI: 10.1016/j.jadr.2025.100919

Hiroshi Tateishi , Hiroko Kunitake , Masahiro Ohgidani , Shogo Inamine , Yutaka Kunitake , Toru Murakawa , Ryohei Kojima , Jun Kikuchi , Takumi Shiraishi , Ken Takada , Shota Shiba , Masataka Hirano , Airi Fukai , Akira Tomonari , Takahiro A Kato , Akira Monji , Yoshito Mizoguchi

Background The neuroinflammatory hypothesis has been proposed as the pathophysiology of depression, and microglia are suggested to have crucial roles by modulating neuroinflammatory responses in patients with depression. We have originally developed human blood induced microglia-like (iMG) cells, which are surrogate cells to predict activities of human brain microglia for reverse-translational research. Repetitive transcranial magnetic stimulation (rTMS) is an effective therapeutic method for improving depressive symptoms in patients with treatment-resistant depression (TRD); however, its details remain unknown. The aim of this study was to predict how rTMS alters the phenotype of microglia using iMG cells of patients with TRD.

Methods Five patients with TRD were enrolled in a frequency (10 Hz) rTMS study. Microarray analysis of the iMG cells of patients with TRD at baseline and the end of the 6-week rTMS treatment was performed in the five domains of immunity, inflammation, phagocytosis, metabolic syndrome, and lipids.

Results Three of the five were rTMS responders and two were non-responders for depressive symptoms. Microarray analysis of responders showed that rTMS treatment significantly increased the RNA expression of 21 genes, including genes related to neuroinflammation, acting in a direction to promote neuroinflammation, and significantly decreased four genes.

Limitations The main limitations were the small sample size and the lack of control conditions using the sham rTMS procedure.

Conclusion This study suggests that rTMS treatment may alter iMG genes, including immune-related genes, in patients with TRD. Future studies should confirm these findings using a larger patient sample size and a sham rTMS procedure.

{"title":"Does rTMS modulate phenotype of microglia in patients with treatment-resistant depression? A transcriptome analysis using iMG cells","authors":"Hiroshi Tateishi , Hiroko Kunitake , Masahiro Ohgidani , Shogo Inamine , Yutaka Kunitake , Toru Murakawa , Ryohei Kojima , Jun Kikuchi , Takumi Shiraishi , Ken Takada , Shota Shiba , Masataka Hirano , Airi Fukai , Akira Tomonari , Takahiro A Kato , Akira Monji , Yoshito Mizoguchi","doi":"10.1016/j.jadr.2025.100919","DOIUrl":"10.1016/j.jadr.2025.100919","url":null,"abstract":"<div><div>Background The neuroinflammatory hypothesis has been proposed as the pathophysiology of depression, and microglia are suggested to have crucial roles by modulating neuroinflammatory responses in patients with depression. We have originally developed human blood induced microglia-like (iMG) cells, which are surrogate cells to predict activities of human brain microglia for reverse-translational research. Repetitive transcranial magnetic stimulation (rTMS) is an effective therapeutic method for improving depressive symptoms in patients with treatment-resistant depression (TRD); however, its details remain unknown. The aim of this study was to predict how rTMS alters the phenotype of microglia using iMG cells of patients with TRD.</div><div>Methods Five patients with TRD were enrolled in a frequency (10 Hz) rTMS study. Microarray analysis of the iMG cells of patients with TRD at baseline and the end of the 6-week rTMS treatment was performed in the five domains of immunity, inflammation, phagocytosis, metabolic syndrome, and lipids.</div><div>Results Three of the five were rTMS responders and two were non-responders for depressive symptoms. Microarray analysis of responders showed that rTMS treatment significantly increased the RNA expression of 21 genes, including genes related to neuroinflammation, acting in a direction to promote neuroinflammation, and significantly decreased four genes.</div><div>Limitations The main limitations were the small sample size and the lack of control conditions using the sham rTMS procedure.</div><div>Conclusion This study suggests that rTMS treatment may alter iMG genes, including immune-related genes, in patients with TRD. Future studies should confirm these findings using a larger patient sample size and a sham rTMS procedure.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100919"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variations in suicidality across multiple social identities in asexual people: An intersectionality analysis

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-22 DOI: 10.1016/j.jadr.2025.100921

Sinéad Kelleher , Mike Murphy

This study draws upon intersectionality theory to describe variations in suicidal ideation and behaviour across gender, romantic identity, race and age among a sample of self-identified asexual individuals. Using data from the 2020 Ace Community Survey (n = 10, 005), interactive multinomial logistic regression models were used to assess the impact of various social identities on suicidal behaviour and ideation, as well as the presence of any significant interactions. Findings indicate that (a) being female and BIPOC and (b) being nonbinary/trans and aromantic or currently questioning one’s romantic identity yielded significantly higher odds of reporting suicidal ideation. Findings also indicate that being aromantic and in the middle (30 – 44) or older (45+) age category resulted in significantly lower odds of suicidal ideation. No interaction effects were found to be statistically significant for suicidal behaviour. This study contributes to growing research in the area of intersectionality and, specifically, the need for researchers to consider how multiple social identities interact to impact the mental health and well-being of asexual individuals. Policy and practice implications are discussed.

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引用次数: 0

Examining the latent structure of adverse childhood experiences in a sample of adults from the United States using exploratory structural equation modelling

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-20 DOI: 10.1016/j.jadr.2025.100923

Christa McCutchen, Philip Hyland

Background

A considerable amount of research has been conducted to determine the detrimental impacts that adverse childhood experiences (ACEs) can have on physical and mental health. Many studies have used ACE questionnaires to measure these events; however, there is some debate regarding the proper theoretical model for ACEs. This study was conducted to evaluate the most commonly used 10-item ACE questionnaire to determine the latent structure of ACEs in the context of psychological wellbeing and internalizing psychopathology.

Methods

A representative sample of adults (n = 1839) in the United States completed self-report measures. Exploratory Structural Equation Modelling (ESEM) was utilized to explore the latent structure of ACEs in the presence of negative and positive mental health outcomes and controlling for sex and race/ethnic categories.

Results

A one-factor model of the ACEs questionnaire provided reasonable fit to sample data and was deemed the most interpretable solution. The ACEs latent variables were positively correlated with internalizing psychopathology (β = 0.52) and negatively associated with psychological wellbeing (β = −0.44). Females had higher ACE scores and several racial/ethnic group differences were evident.

Conclusion

The optimal representation of the latent structure of the ten ACE items is a unidimensional structure. Implications for assessment and research are discussed.

{"title":"Examining the latent structure of adverse childhood experiences in a sample of adults from the United States using exploratory structural equation modelling","authors":"Christa McCutchen, Philip Hyland","doi":"10.1016/j.jadr.2025.100923","DOIUrl":"10.1016/j.jadr.2025.100923","url":null,"abstract":"<div><h3>Background</h3><div>A considerable amount of research has been conducted to determine the detrimental impacts that adverse childhood experiences (ACEs) can have on physical and mental health. Many studies have used ACE questionnaires to measure these events; however, there is some debate regarding the proper theoretical model for ACEs. This study was conducted to evaluate the most commonly used 10-item ACE questionnaire to determine the latent structure of ACEs in the context of psychological wellbeing and internalizing psychopathology.</div></div><div><h3>Methods</h3><div>A representative sample of adults (<em>n</em> = 1839) in the United States completed self-report measures. Exploratory Structural Equation Modelling (ESEM) was utilized to explore the latent structure of ACEs in the presence of negative and positive mental health outcomes and controlling for sex and race/ethnic categories.</div></div><div><h3>Results</h3><div>A one-factor model of the ACEs questionnaire provided reasonable fit to sample data and was deemed the most interpretable solution. The ACEs latent variables were positively correlated with internalizing psychopathology (β = 0.52) and negatively associated with psychological wellbeing (β = −0.44). Females had higher ACE scores and several racial/ethnic group differences were evident.</div></div><div><h3>Conclusion</h3><div>The optimal representation of the latent structure of the ten ACE items is a unidimensional structure. Implications for assessment and research are discussed.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100923"},"PeriodicalIF":0.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating cultural influences on the associations between rumination and symptoms of posttraumatic stress disorder among European Australian and Chinese Australian trauma survivors

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-20 DOI: 10.1016/j.jadr.2025.100924

Haoxiang Li , Larissa Shiying Qiu , Joshua Wong , Winnie Lau , Richard Bryant , July Lies , Belinda Liddell , Laura Jobson

This study investigated the moderating effect of cultural variables (cultural group, self-construal and cognitive style) on the association between rumination and PTSD symptoms among European Australian and Chinese Australian adult trauma survivors. European Australian (n = 111) and Chinese Australian (n = 111) trauma survivors were recruited through social media advertisements on Facebook, WeChat and RED and completed an on-line questionnaire assessing rumination, cultural variables and PTSD symptomatology. There was no evidence that cultural group moderated the associations between brooding and PTSD symptomatology. interdependent self-construal moderated the associations between all three types of rumination and PTSD symptomatology, such that the association between each type of rumination (brooding, reflection and trauma-specific) and PTSD symptomatology increased at higher levels of interdependence. These findings highlight the importance of considering rumination regardless of the cultural background of trauma survivors. Additionally, it may be clinically beneficial to consider the impacts of trauma and rumination on interdependent aspects of the self and consider the socio-cultural context (including an individual’s values and self-concept). Further research is crucial for integrate cross-cultural psychology theories and empirical research to better conceptualize rumination and its role in maintaining psychopathology in Asian contexts.

{"title":"Investigating cultural influences on the associations between rumination and symptoms of posttraumatic stress disorder among European Australian and Chinese Australian trauma survivors","authors":"Haoxiang Li , Larissa Shiying Qiu , Joshua Wong , Winnie Lau , Richard Bryant , July Lies , Belinda Liddell , Laura Jobson","doi":"10.1016/j.jadr.2025.100924","DOIUrl":"10.1016/j.jadr.2025.100924","url":null,"abstract":"<div><div>This study investigated the moderating effect of cultural variables (cultural group, self-construal and cognitive style) on the association between rumination and PTSD symptoms among European Australian and Chinese Australian adult trauma survivors. European Australian (<em>n</em> = 111) and Chinese Australian (<em>n</em> = 111) trauma survivors were recruited through social media advertisements on Facebook, WeChat and RED and completed an on-line questionnaire assessing rumination, cultural variables and PTSD symptomatology. There was no evidence that cultural group moderated the associations between brooding and PTSD symptomatology. interdependent self-construal moderated the associations between all three types of rumination and PTSD symptomatology, such that the association between each type of rumination (brooding, reflection and trauma-specific) and PTSD symptomatology increased at higher levels of interdependence. These findings highlight the importance of considering rumination regardless of the cultural background of trauma survivors. Additionally, it may be clinically beneficial to consider the impacts of trauma and rumination on interdependent aspects of the self and consider the socio-cultural context (including an individual’s values and self-concept). Further research is crucial for integrate cross-cultural psychology theories and empirical research to better conceptualize rumination and its role in maintaining psychopathology in Asian contexts.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100924"},"PeriodicalIF":0.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual Reality in the treatment of depression; what therapeutic strategies does VR target?

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-01 DOI: 10.1016/j.jadr.2025.100912

Nancy Kramer Freher , Martine van Bennekom , Anika Bexkens , Wim Veling , Claudi L.H. Bockting

Background

Major Depressive Disorder (MDD) is one of the most prevalent mental health conditions and has a tremendous impact on those affected. Immersive Virtual Reality (VR) technology has high potential to improve psychotherapy for MDD, as VR can personalize the treatment process and directly influence affect. Research on VR interventions for MDD is emerging, but current applications for treatment are heterogeneous and lack strong theoretical support. This scoping review aims to identify the therapeutic strategies that should and can be targeted in VR interventions for depression.

Methods

A systematic search of the literature was conducted in PubMed, PsycINFO, Ovid Medline, Embase, Web of Science, Google Scholar, Clinical Trials Register, and the ‘Dutch Trial Register’ from inception through November 2023 to identify the most relevant research.

Results

Findings from 43 studies included in this review resulted in the following potential therapeutic strategies: 1) psychoeducation (n=5), 2) behavioral activation (n=16), 3) cognitive restructuring (n=4), 4) enhancing positive affect (n=5), 5) mental imagery (n=4), 6) skills training (n=3), 7) enhancing cognitive functioning (n=3), and 8) other (n=3).

Limitations

We did not conduct a systematic assessment of the methodological quality of the studies nor perform a statistical analysis of the results.

Conclusions

VR shows potential to facilitate the treatment process for patients with depression in different ways, providing excellent prospects for personalizing and potentially improving the treatment of MDD. Future studies should focus on evaluating presumed mechanisms of change to fully understand the added value of VR in the treatment of depression.

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引用次数: 0

Effects of acute stress on executive functions in depression, generalised anxiety and borderline personality disorder

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-01 DOI: 10.1016/j.jadr.2025.100917

T.M. Scott , Joanne M. Dickson

Background

Acute stress adaptively alters executive functions (EFs) essential for emotion regulation. Emerging systems of psychiatric classification, such as the Hierarchical Taxonomy of Psychopathology (HiTOP) and the Research Domain Criteria, emphasise the underlying mechanisms and dimensional nature of psychopathology. Distress disorders—a subfactor within the HiTOP model including major depressive disorder, generalised anxiety disorder and borderline personality disorder—are characterised by altered stress reactivity, impaired emotion regulation, and modest responsiveness to first-line psychotherapies. This systematic review sought to examine whether distress disorders and their related symptoms confer heightened vulnerability to transient EF impairment under conditions of acute stress.

Methods

A comprehensive search of articles published in ProQuest, PsycINFO, PubMed, Scopus and Web of Science prior to December 31st, 2022 identified 17 suitable studies examining stress-induced alterations to working memory, inhibition and cognitive flexibility in the context of distress disorders and associated symptoms.

Results

This review found a heightened susceptibility to stress-induced impairment of working memory in depression, and of response inhibition in borderline personality disorder—even for sub-clinical presentations of depressive symptoms wherein diagnostic criteria for a depressive disorder were not met. Findings for cognitive flexibility were inconclusive.

Limitations

While a thorough systematic review was conducted, heterogeneity in study design and methodologies precluded inclusion of a meta-analysis.

Conclusions

The findings indicate that altered stress reactivity leads to maladaptation of EF under acute stress, and subsequent disruption of adaptive emotion regulation strategies. The present finding may help account for non-responsiveness among therapeutic interventions predicated upon cognitively-demanding emotion regulation strategies.

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引用次数: 0

1-year naturalistic follow-up of a Randomised Double-Blind, Placebo-Controlled Trial (“NoMAD”) Exploring the Effectiveness of Micronutrients in Improving Symptoms of Anxiety and Depression

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-01 DOI: 10.1016/j.jadr.2025.100913

Amy Coët, F. Meredith Blampied, Julia J. Rucklidge

Background

A randomised controlled trial (NoMAD trial) showed micronutrients led to faster recovery from depression and anxiety compared with placebo. The RCT was followed by a 10 week open-label component and then a one year naturalistic review.

Aims

This 1-year follow-up of NoMAD explored the association between dominant treatment at 1-year follow-up with psychiatric outcomes.

Study design/Methods

Ninety-four (63 %) of the original 150 NoMAD participants completed 1-year follow-up. Primary outcomes included Generalised Anxiety Disorder-7 questionnaire (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and Modified-Clinical Global Impression-Improvements (MCGI-I). Outcomes were explored based on dominant therapy at 1-year follow-up: Micronutrients (n = 20), Psychiatric Medications (n = 9), and No Treatment (n = 56). Nine participants could not be grouped due to mixed treatments at follow-up.

Results

Regardless of dominant therapy, participants were functioning significantly better at 1-year compared to baseline. There was little change from end of 10 weeks of open-label micronutrient treatment, with the exception of depression scores, which were significantly lower (d = 0.4; p<.001). Most participants had either no or mild depression (78 %) and anxiety (85 %) scores at 1-year follow-up. Those who stayed on micronutrients were those who experienced better response at end of open-label compared with those who stopped or switched to medications. They also showed a greater reduction in health anxiety from end of open-label to 1-year follow-up compared with others. The main reason cited for stopping micronutrients was the cost. Limitations include a third of original sample lost to follow-up and uneven group sizes limit generalisability of results.

Conclusion

Participants, regardless of long-term supplementation, were functioning well at one year.

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引用次数: 0

Assessing brain morphological correlates of premenstrual symptoms in young healthy females

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-01 DOI: 10.1016/j.jadr.2025.100916

Sara B. Marjanovic , Madelene Christin Holm Bukhari , Rikka Kjelkenes , Irene Voldsbekk , Claudia Barth , Lars T. Westlye

While 90 % of females with a menstrual cycle will experience premenstrual symptoms in their reproductive years, it is estimated that 20 % experience treatment-warranted emotional, behavioral, or somatic symptoms in the premenstrual phase of their menstrual cycle. Premenstrual symptoms have been partly attributed to the brain's sensitivity to menstrual cycle-related hormonal fluctuations, which may be modulated by individual differences in the structural characteristics of the brain. In a population-based sample of 292 non-pregnant females aged 23–43 years, we tested for associations between self-reported premenstrual symptom load and T1-weighted MRI based brain measures of cortical thickness, volume, and surface area as well as subcortical volumes, not controlling for menstrual cycle phase. After corrections for multiple comparison, linear models including age revealed significant positive associations between premenstrual symptom load and the volume of the left posterior cingulate cortex. Item-level analyses confirmed that the association with overall symptom load were not driven by specific symptom domains. These findings partly overlap with previous brain morphological findings in individuals with PMS and could possibly represent a non-phase dependent correlate of premenstrual symptoms.

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引用次数: 0

Validity and Reliability of the Dutch version of the Affective Control Scale

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-01 DOI: 10.1016/j.jadr.2025.100910

Hendrik-Jan De Vuyst , James W. Griffith , Eline Belmans , Filip Raes

Background

The Affective Control Scale (ACS) is a widely-used instrument for evaluating the fear of losing control over emotions, a key factor implicated in anxiety and depressive disorders. However, despite its widespread use, substantial inconsistencies have raised questions about the scale's reliability and validity.

Methods

This study aimed to assess the factor structure of the Affective Control Scale (ACS) using confirmatory factor analysis (CFA) in two Dutch-speaking samples (n₁ = 250, n₂ = 325). Various factor structures, as previously proposed in the literature, were examined. Convergent validity was assessed by correlating the resulting factors with concurrent measures of anxiety and depression.

Results

In both samples, a bifactor model excluding reverse-scored items demonstrated the best overall fit. However, despite showing high reliabilities, the specific factors exhibited low attributable score variance. Furthermore, the convergent validity assessment revealed poor associations between these specific factors and measures of anxiety and depression.

Limitations

The study's generalizability is limited due to the predominantly female samples. Additionally, the complexities of bifactor models may lead to overfitting of the data.

Conclusions

We conclude that a bifactor model excluding all reverse-scored items offers the most robust fit. Nevertheless, while the ACS is effective in measuring general fear of emotions, its ability to assess specific emotional fears is limited. Clinically, these findings underscore the importance of focusing on the overall fear of emotions rather than its specific components. Therefore, we recommend the use of a simplified, 30-item version of the ACS that assesses general fear of emotions.

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引用次数: 0

Home-use transcranial direct current stimulation (tDCS) as a safe, effective, and feasible application in depression: A randomized, single-blind, placebo-controlled trial

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-04-01 DOI: 10.1016/j.jadr.2025.100902

Tuba Aktürk , Mehmet Yücel Ağargün , Sümeyye Özdemir , Esra Dalmızrak , Bahar Güntekin

Introduction

Anodal transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) alleviates depression symptoms and enhances cognitive functions in major depressive disorder (MDD) patients. Previously, these outcomes were demonstrated primarily in clinical or laboratory settings through randomized placebo-controlled trials. Our objective was to assess the feasibility and effectiveness of asynchronously supervised, home-use tDCS on both mood and cognition in MDD patients, within a randomized, single-blind, placebo-controlled trial.

Method

Twenty MDD patients were randomized into active (N = 11) and sham (N = 9) tDCS groups. The protocol entailed daily 30-minute sessions at 2 mA with the anode over the left-DLPFC and the cathode over the right-DLPFC, conducted five days a week for three weeks. Sham stimulation consisted of a brief 30-second interval between 10-second ramp-up and down periods. After initial training, patients were administered tDCS at home and were evaluated using depression-related questionnaires and cognitive tests at baseline and post-intervention. Adherence and tolerance were asynchronously monitored via a remote supervision platform.

Results

High tolerability (adverse-event incidence rate of 0.63 %) and strong adherence (an average of 14.45 out of 15 sessions completed) were observed for home-use tDCS. The active group demonstrated significantly greater improvements in depression scores (BDI-II) and in cognitive performance (Digit Span tests), compared to the sham group, which received placebo treatment with the same protocol.

Conclusion

The results of our study demonstrate that home-use tDCS is feasible, safe and might be effective for patients with depression, offering a more accessible and cost-effective approach to neuromodulation treatments in mental health.

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引用次数: 0