Journal of Affective Disorders Reports最新文献_第6页

Decreased PON1 activity as a biological marker for depressive disorders: a narrative review PON1活性降低作为抑郁症的生物学标志物：一项叙述性综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100947

Oleg A. Levada, Oleksandra S. Troian

Background

This study conducts a narrative review to summarize evidence regarding changes in serum/plasma paraoxonase 1 (PON1) activity in patients with major depressive disorder (MDD) or other depressive disorders and assess their possible marker value.

Methods

We searched the PubMed database for articles published from inception to December 2024 on the relationship between depression and PON1 activities/concentrations.

Results

Seventeen articles from 2006 to 2022 were included in the final analysis. 70 % of the studies demonstrated a decline in PON1 (predominantly arylesterase activity) during MDD episodes and depressive disorders induced by methamphetamine and Parkinson`s disease. Lower PON1 paraoxonase activity was associated with the number of previous depressive episodes (DE), worse outcomes, and higher DE severity. Two studies showed an increase in PON1 activity after antidepressant treatment. The decline of PON1 has a genetic predisposition. QQ and QR genotypes of PON1 increased the odds of depression. MDD patients with QQ genotype (in contrast to QR and RR) showed lowered PON1 activity.

Conclusion

There is a decline in arylesterase/paraoxonase activity and PON1 concentrations in MDD and secondary depressive disorders. The decline is also associated with the severity and number of DE. Antidepressant treatment might increase PON1 activity. Genetic predisposition and epigenetic mechanisms that decrease PON1 activity might disrupt antioxidative mechanisms and lipid metabolism, which could be a part of complex pathogenesis and/or lead to comorbid somatic MDD pathology related to accelerated aging. PON1 activity and concentrations decline might be a marker for MDD and other DE, whereas PON1 increase – for treatment efficacy.

本研究对重度抑郁症（MDD）或其他抑郁症患者血清/血浆对氧磷酶1 （PON1）活性变化的证据进行综述，并评估其可能的标志物价值。方法检索PubMed数据库中自成立至2024年12月发表的有关抑郁症与PON1活性/浓度关系的文章。结果2006 - 2022年共纳入17篇文章。70%的研究表明，在甲基苯丙胺和帕金森病引起的重度抑郁症发作和抑郁症期间，PON1（主要是芳基酯酶活性）下降。较低的PON1对氧磷酶活性与既往抑郁发作（DE）次数、较差的结局和较高的DE严重程度相关。两项研究显示抗抑郁治疗后PON1活性增加。PON1的下降有遗传易感性。PON1的QQ和QR基因型增加抑郁的几率。QQ基因型MDD患者（与QR和RR相比）PON1活性降低。结论重度抑郁症和继发性抑郁症患者芳香酯酶/对氧磷酶活性和PON1浓度均有下降。这种下降也与DE的严重程度和次数有关。抗抑郁治疗可能会增加PON1活性。遗传易感性和表观遗传机制降低PON1活性可能会破坏抗氧化机制和脂质代谢，这可能是复杂发病机制的一部分和/或导致与加速衰老相关的躯体MDD共病病理。PON1活性和浓度的下降可能是MDD和其他DE的标志，而PON1的增加可能是治疗效果的标志。

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引用次数: 0

Effect of combined transcranial direct current stimulation and cognitive training on brain microstructure and network homogeneity in late-life depression: a pilot study 经颅直流电刺激联合认知训练对老年抑郁症脑结构和网络同质性影响的初步研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100973

Junghee Ha , Yu Fang , Chandan Kittur , Greg O. Cron , Ok Kyu Song , Jin Young Park , Jin Hyung Lee

Background

Depression and cognitive decline frequently coexist in older individuals. However, effective treatment options remain limited. Neuromodulation has shown potential beyond traditional cognitive training; however, its specific effects on brain connectivity and white matter structures remain unclear. The purpose of this study was to evaluate the effects of combining transcranial direct current stimulation (tDCS) with cognitive training on white matter microstructure integrity and default mode network (DMN) homogeneity in older adults with cognitive deficits and depressive symptoms.

Methods

This double-blind, randomized sham-controlled study compared cognitive training combined with either anodal or sham tDCS in older adults with late-life depression and cognitive decline. Multimodal magnetic resonance imaging was used to assess DMN homogeneity and white matter microstructure at baseline and after 5 weeks of treatment.

Results

Cognitive training, whether combined with active or sham tDCS, led to significantly increased fractional anisotropy averaged across all brain regions, indicating an overall improvement in white matter integrity. However, tDCS did not provide additional benefit to white matter integrity. A higher baseline anterior-posterior DMN association correlated with better cognitive function, and treatment remission increased posterior DMN homogeneity. Enhancements in cingulum white matter integrity were associated with improvements in depressive symptoms, cognition, and brain-derived neurotrophic factor levels.

Conclusions

Cognitive training leads to improved white matter integrity in older adults experiencing cognitive deficit and depression. Changes in the structural integrity of the cingulum can predict clinical outcomes. No additional benefits of tDCS on white matter integrity or network homogeneity were observed.

在老年人中，抑郁症和认知能力下降经常并存。然而，有效的治疗选择仍然有限。神经调节已显示出超越传统认知训练的潜力；然而，它对大脑连通性和白质结构的具体影响尚不清楚。本研究的目的是评估经颅直流电刺激（tDCS）联合认知训练对老年认知缺陷伴抑郁症状患者白质微结构完整性和默认模式网络（DMN）同质性的影响。方法这项双盲、随机、假对照研究比较了认知训练联合正负或假性tDCS对老年抑郁症和认知能力下降的影响。在基线和治疗5周后，采用多模态磁共振成像评估DMN均匀性和白质微观结构。结果认知训练，无论是联合活动tDCS还是假tDCS，都显著增加了所有脑区的平均各向异性分数，表明白质完整性的总体改善。然而，tDCS对白质完整性没有额外的好处。较高的基线前后DMN关联与更好的认知功能相关，治疗缓解增加后DMN均匀性。扣带白质完整性的增强与抑郁症状、认知和脑源性神经营养因子水平的改善相关。结论认知训练可改善老年认知障碍和抑郁症患者脑白质完整性。扣带结构完整性的改变可以预测临床结果。没有观察到tDCS对白质完整性或网络均匀性的额外益处。

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引用次数: 0

Examining disordered eating and depressive symptomatology in adults with Sickle Cell Disease (SCD): Gender differences 检查成人镰状细胞病（SCD）的饮食失调和抑郁症状：性别差异

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100962

Deja Buckner , Bridgette Pittman Blackwell , John J. Sollers III , W. Jeff Bryson , Alexandria McDougald , Mary Wood , Camela S. Barker , Jessica Miller , Elaine Whitworth , Erika N. Cubilete , Jenny Norris , Danielle May , Meredyth Galliher , Beyonnshea N. Lucas , Cara Green , Erika Cubilete , Ben Bayan , Ashley Lopez , John J. Sollers IV , Malik Muhammad , Christopher L. Edwards

Sickle cell disease (SCD) is a genetic disorder characterized by distorted red blood cells that possess a decreased ability to carry oxygen and carbon dioxide throughout the body, primarily impacting individuals of African, Mediterranean, and South American backgrounds. The present study sought to examine the relationship between disordered eating patterns and depressive symptomatology by comparing self-identified gender differences in patients with SCD. Disordered eating was measured using the Eating Disorder Inventory (EDI-I), which encompasses four subscales including body dissatisfaction (BD), ineffectiveness (IE), interpersonal distress (ID), and interoceptive awareness (IA). Depressive symptoms were assessed using the Beck Depression Inventory-I (BDI-I) and the Center for Epidemiological Studies-Depression (CES-D). In a sample of 37 Black adults with SCD (30 female and 7 male), the results showed that women exhibited higher body dissatisfaction and depressive symptoms in comparison to men (p < .05). Women with SCD simultaneously experiencing high incidences of body dissatisfaction and depressive symptoms could impact their prognosis, psychological functioning, and overall health. Further research is needed to examine this issue and its implications.

镰状细胞病（SCD）是一种遗传性疾病，其特征是红细胞变形，在全身携带氧气和二氧化碳的能力下降，主要影响非洲、地中海和南美背景的个体。本研究试图通过比较SCD患者自我认同的性别差异来研究饮食失调模式与抑郁症状之间的关系。饮食失调使用饮食失调量表（edii）进行测量，该量表包含四个子量表，包括身体不满（BD）、无效（IE）、人际困扰（ID）和内感受意识（IA）。采用贝克抑郁量表i （BDI-I）和流行病学研究中心抑郁量表（CES-D）对抑郁症状进行评估。在37名患有SCD的黑人成年人（30名女性和7名男性）的样本中，结果显示，与男性相比，女性表现出更高的身体不满和抑郁症状（p < 0.05）。患有SCD的女性同时经历身体不满和抑郁症状的高发可能会影响她们的预后、心理功能和整体健康。需要进一步的研究来检验这个问题及其影响。

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引用次数: 0

Knowledge mapping of biofeedback for depression from 1999 to 2023: A bibliometric analysis 1999 - 2023年抑郁症生物反馈知识图谱：文献计量学分析

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100946

Junzhe Cheng , Zhenchu Tang , Yubo Wang , Shazia Rehman , Zhixuan Ren , Yumeng Ju , Jin Liu , Mi Wang , Bangshan Liu , Yan Zhang

Background

Depression is a leading neuropsychiatric disorder causing disability worldwide. In recent years, biofeedback has been increasingly applied in the clinical treatment of depression. This study aims to explore the emerging trends and knowledge structure in biofeedback for depression.

Methods

The retrieval was conducted in the Science Citation Index-Expanded database from 1999 to 2023. The CiteSpace, VOSviewer, Microsoft Excel 365, and a bibliometric online platform were used to visualize bibliometric networks and conduct statistical analyses, exploring the relationships and contributions among countries/regions, institutions, funding agencies, journals, authors, and keywords.

Results

A total of 540 publications related to biofeedback for depression were included in this analysis, revealing a two-phase growth trend. From 1999 to 2013, there was steady but slow growth, with a compound annual growth rate of 7.49 %. This was followed by an explosive growth phase from 2014 onwards, with a 23.02 % annual growth rate, peaking at 71 publications in 2022. The United States ranked top in the number of publications, citations, and h-index, while Bodurka, J was the most prolific author. The University of London produced the highest number of publications. The most frequent keywords were "depression" and "biofeedback," with "anxiety," "chronic pain," and "therapy" also prominent, underscoring the potential of biofeedback in treating depression and its comorbidities.

Conclusion

Since 2010 and 2016, scientific interest in biofeedback for depression has experienced two significant growths. The United States leads in this field, with Germany and China following. However, the scope of biofeedback applications for depression treatment is still limited, and there is a lack of inter-institutional collaboration. Biofeedback is an important direction of non-invasive adjuvant options for depression treatment in clinical practice.

抑郁症是世界范围内导致残疾的主要神经精神疾病。近年来，生物反馈在抑郁症的临床治疗中得到越来越多的应用。本研究旨在探讨抑郁症生物反馈的新趋势和知识结构。方法在1999 ~ 2023年的Science Citation Index-Expanded数据库中进行检索。利用CiteSpace、VOSviewer、Microsoft Excel 365和文献计量在线平台将文献计量网络可视化并进行统计分析，探索国家/地区、机构、资助机构、期刊、作者和关键词之间的关系和贡献。结果共纳入540篇抑郁症生物反馈相关文献，呈两阶段增长趋势。1999 - 2013年，经济增长平稳但缓慢，年复合增长率为7.49%。随后从2014年开始进入爆炸性增长阶段，年增长率为23.02%，2022年达到71篇出版物的峰值。美国的论文发表量、引用量、h指数均居首位，而Bodurka J是最多产的作者。伦敦大学发表的出版物数量最多。最常见的关键词是“抑郁”和“生物反馈”，“焦虑”、“慢性疼痛”和“治疗”也很突出，强调了生物反馈在治疗抑郁症及其合并症方面的潜力。结论自2010年和2016年以来，对抑郁症生物反馈的科学兴趣经历了两次显著增长。美国在这一领域处于领先地位，德国和中国紧随其后。然而，生物反馈应用于抑郁症治疗的范围仍然有限，并且缺乏机构间的合作。生物反馈是临床治疗抑郁症非侵入性辅助选择的重要方向。

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引用次数: 0

Understanding the gaming disorder–depression co-occurrence: A narrative literature review 理解游戏障碍与抑郁症的共现：叙述性文献综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100961

An-Pyng Sun , Stephanie Diez

Because gaming disorder (GD) often co-occurs with depression, understanding how both disorders work together enables clinicians to better treat individuals with GD–depression comorbidity. The extant literature on GD–depression comorbidity is unsystematic and contradictory, with some studies suggesting depression predicts GD but not vice versa, some claiming GD predicts depression but not vice versa, and some proposing a bidirectional relationship between the two. The goal of this narrative review is to explore and organize these findings to establish a holistic and coherent conceptual framework that explains how GD co-occurs with depression.

The PubMed, PsycINFO, and Web of Sciences databases were searched for relevant peer-reviewed journal articles published 2013–2025, using the search terms (gaming disorder OR gaming addiction) AND (depression OR depressive symptoms). Results included 127 empirical studies that meet the inclusion criteria and are relevant to building a coherent map to explain the GD–depression relationship. The resulting framework combines their findings to map paths and mechanisms, as well as salient contextual factors, explaining how GD and depression may be connected. Specifically, the self-medication perspective indicates that psychiatric disorders, adverse life experiences, and other factors may predict GD via the mediation of depression. By comparison, the negative consequences perspective suggests that GD may lead to negative consequences (e.g., withdrawal, unhealthy lifestyles, and compromised self-esteem), which subsequently foster depression. Together, these two paths form a chronic vicious cycle.

因为游戏障碍（GD）经常与抑郁症同时发生，了解这两种疾病是如何共同作用的，可以使临床医生更好地治疗患有游戏障碍和抑郁症共病的个体。现有的关于抑郁与抑郁共病的文献缺乏系统性和矛盾性，一些研究认为抑郁可以预测抑郁，而GD不能预测抑郁，一些研究认为GD可以预测抑郁，而GD不能预测抑郁，还有一些研究认为两者之间存在双向关系。这篇叙述性综述的目的是探索和组织这些发现，以建立一个整体和连贯的概念框架，解释焦虑如何与抑郁症共同发生。使用搜索词（游戏障碍或游戏成瘾）和（抑郁或抑郁症状），在PubMed、PsycINFO和Web of Sciences数据库中检索了2013-2025年发表的相关同行评议期刊文章。结果包括127个符合纳入标准的实证研究，这些研究与构建一个连贯的地图来解释gd -抑郁关系有关。最终的框架结合了他们的发现，绘制出路径和机制，以及显著的背景因素，解释了GD和抑郁症是如何联系在一起的。具体而言，自我药物治疗的观点表明，精神障碍、不良生活经历和其他因素可能通过抑郁的中介来预测GD。相比之下，消极后果观点认为，焦虑可能导致消极后果（例如，退缩、不健康的生活方式和自尊受损），这些后果随后会助长抑郁。这两条路一起形成了一个长期的恶性循环。

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引用次数: 0

Beyond goodbye: daily emotion regulation sensed from deceased loved ones 告别之外：从已故亲人身上感受到的日常情绪调节

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100972

Eva-Maria Stelzer , Melissa Flores , Emily Butler , Jeff Greenberg , Matthias R. Mehl , David Sbarra , Mary-Frances O’Connor

Background

Attachment theory posits mental working models of close relationship partners that function as a source of support in the partner’s absence, and experimental evidence shows that thoughts of living attachment figures provide stress buffering. Bereaved individuals may benefit from accessing mental representations of deceased loved ones as well. This daily diary study examined whether sensing emotion regulation from the deceased is associated with mental health outcomes in conjugally bereaved adults.

Methods

Grief and well-being were assessed at baseline and after a 14-day daily diary study. Each evening, participants chose from a list of emotion regulation strategies they sensed from the deceased on that day, in addition to brief ratings of well-being (comprised of life satisfaction, positive and negative affect) and grief.

Results

Widowed participants (N = 156) experienced greater negative affect on days when they reported many emotion regulation strategies they sensed from the deceased. However, between participants, those who reported more emotion regulation strategies from the deceased on average across the study period reported more positive affect and more life satisfaction compared to people who reported fewer strategies across the 14 days. There were no associations between emotion regulation sensed from the deceased and grief. Follow up analyses found no indication of reverse causation, but found moderation by time since loss.

Discussion

In the long-term, “imagined” emotion regulation sensed from one’s deceased partner was linked to positive mental health indicators. In the short-term, however, emotion regulation strategies sensed from the deceased were associated with greater negative affect.

依恋理论假设亲密关系伴侣的心理工作模式在伴侣缺席时作为支持的来源，实验证据表明，生活依恋形象的想法提供了压力缓冲。失去亲人的人也可能从接触已故亲人的心理表征中受益。这项每日日记研究调查了来自死者的感知情绪调节是否与丧偶成人的心理健康结果有关。方法在基线和14天的每日日记研究后评估悲伤和幸福感。每天晚上，参与者从他们当天从死者身上感受到的情绪调节策略列表中进行选择，此外还有简短的幸福感评分（包括生活满意度、积极和消极影响）和悲伤。结果丧偶的参与者（N = 156）在报告他们从死者身上感受到的许多情绪调节策略的日子里经历了更大的负面影响。然而，在参与者之间，与在14天内报告较少策略的人相比，那些在研究期间平均从死者那里获得更多情绪调节策略的人报告了更多的积极影响和更高的生活满意度。从死者身上感受到的情绪调节和悲伤之间没有联系。后续分析没有发现反向因果关系的迹象，但发现随着时间的推移，损失有所缓和。从长期来看，从已故伴侣身上感受到的“想象的”情绪调节与积极的心理健康指标有关。然而，在短期内，从死者身上感受到的情绪调节策略与更大的负面情绪有关。

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引用次数: 0

Suicide and utilisation of health-care services for depressive disorders among health-care professionals and clerics in Norway 2008–2021: a case-control study 2008-2021年挪威保健专业人员和神职人员自杀和利用保健服务治疗抑郁症的情况：一项病例对照研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100944

Helene Seljenes Dalum , Erlend Hem , Øivind Ekeberg , Kim Stene-Larsen , Lars Johan Hauge

Background

There is a lack of research on suicide and depression among health-care professionals, and most studies on depression are based on self-report. Thus, we conducted a register-based study to examine suicide risk and health-care utilisation for depressive disorders, both in the primary and specialist health-care services, among physicians, veterinarians, dentists, psychologists, pharmacists, physiotherapists, and nurses, as well as among clerics, compared to controls with higher and lower education.

Methods

The study is a case-control analysis based on Norwegian nationwide registers from 2008 to 2021. Occupations were included according to the Classification of Occupations provided by Statistics Norway. Information on occupations were linked to the Norwegian Cause of Death Registry, the Norwegian Patient Registry, and the Norwegian Registry for Primary Care.

Results

Suicide risk was not significantly elevated in any of the professions investigated. Physicians, psychologists, physiotherapists, and nurses had significantly lower rates as compared to controls with lower education. Psychologists and clerics had a higher likelihood of utilising specialist health-care services for depression as compared to controls with both higher and lower education. Clerics also utilised primary health-care services for depression to a larger extent as compared to both groups.

Limitations

Occupational exposure is only one of many factors contributing to depression and suicide risk. Other risk factors such as working conditions or mental illnesses other than depression were not accounted for in the present study.

Conclusions

Preventive mental health measures and timely treatment of depression among health-care professionals in need is important and may contribute to suicide prevention.

背景目前对医疗保健专业人员自杀和抑郁症的研究较少，大多数关于抑郁症的研究都是基于自我报告。因此，我们进行了一项基于登记的研究，以检查抑郁症的自杀风险和医疗保健利用情况，包括在初级和专科医疗保健服务中，在医生、兽医、牙医、心理学家、药剂师、物理治疗师、护士以及神职人员中，与受教育程度较高和较低的对照组进行比较。方法采用2008 - 2021年挪威全国登记病例对照分析。根据挪威统计局提供的职业分类纳入职业。职业信息与挪威死因登记处、挪威病人登记处和挪威初级保健登记处相联系。结果在所有被调查的职业中，自杀风险都没有显著升高。与受教育程度较低的对照组相比，内科医生、心理学家、物理治疗师和护士的患病率明显较低。与受教育程度较高和较低的对照组相比，心理学家和神职人员利用专业保健服务治疗抑郁症的可能性更高。与这两个群体相比，神职人员也在更大程度上利用初级保健服务治疗抑郁症。职业暴露只是导致抑郁和自杀风险的众多因素之一。除抑郁症外，其他风险因素如工作条件或精神疾病在本研究中未被考虑在内。结论预防心理健康措施和及时治疗有需要的卫生保健人员的抑郁症是重要的，可能有助于预防自杀。

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引用次数: 0

Integration of inflammatory biomarkers and family counseling in postpartum depression management: A multidisciplinary perspective 产后抑郁管理中炎症生物标志物和家庭咨询的整合：多学科视角

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100967

Mohamad Awal Lakadjo , Ilham Khairi Siregar , Mohamad Rizal Pautina , Jumadi Mori Salam Tuasikal , Muh Taufiq , Bau Ratu

This correspondence responds to the recent publication by Xie et al. (2025) on immune-inflammatory biomarkers associated with postpartum depression (PPD). We commend the study's methodological rigor and highlight its implications for early detection. Integrating biological screening with psychosocial assessment is essential to address the multifactorial etiology of PPD. Drawing from multidisciplinary perspectives, we emphasize the synergistic role of family functioning and systemic inflammation in shaping maternal mental health outcomes. Recent evidence shows that family-based interventions significantly improve both maternal well-being and infant development. In addition, impaired family dynamics are independently linked to increased antenatal distress, reduced coping, and negative developmental outcomes in children. We advocate for a biopsychosocial approach that combines biomarker monitoring with family counseling as a promising strategy for comprehensive perinatal care. Closing the implementation gap between research and clinical practice is crucial to ensure equitable access to integrative maternal mental health services.

本文回应了Xie等人（2025）最近发表的与产后抑郁症（PPD）相关的免疫炎症生物标志物。我们赞扬该研究方法的严谨性，并强调其对早期发现的影响。将生物学筛查与社会心理评估相结合对于解决PPD的多因素病因至关重要。从多学科的角度来看，我们强调家庭功能和系统性炎症在塑造产妇心理健康结果中的协同作用。最近的证据表明，以家庭为基础的干预措施可显著改善孕产妇福祉和婴儿发育。此外，受损的家庭动态与产前痛苦增加、应对能力降低和儿童负面发展结果独立相关。我们提倡将生物标志物监测与家庭咨询相结合的生物心理社会方法作为全面围产期护理的有前途的策略。缩小研究与临床实践之间的执行差距对于确保公平获得综合孕产妇心理健康服务至关重要。

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引用次数: 0

Atypical automatic processing of interoceptive information in adolescents with alexithymia 述情障碍青少年内感受性信息的非典型自动加工

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100958

Lorenz Rapp, Sandra A. Mai-Lippold, Eleana Georgiou, Olga Pollatos

Background

Alexithymia, characterized by impaired emotional identification and expression, exhibits conceptual and neuroanatomical overlap with atypical interoception - the ability to perceive and process bodily signals. This study investigates in adolescents the link between alexithymia and interoception using the heartbeat-evoked potential (HEP), a brain response reflecting cardiac signal processing.

Methods

Forty-seven healthy subjects (mean age 14.29 years, 53.2% female) underwent HEP recordings across three conditions (an interoceptive task, facial emotion recognition task, and resting condition) and completed the Toronto Alexithymia Scale (TAS-20).

Results

Frontocentral right hemisphere HEP activity during the interoceptive task displayed a negative correlation with TAS-20 total score. The HEP measured in the same area showed a non-significant trend for a negative correlation with two TAS-20 subscales. No significant correlation was observed between alexithymia scores and HEP amplitudes during the other conditions. TAS-20 scores had no significant association with the performance in an interoceptive task.

Limitations

Generalizability to adults is limited due to ongoing emotional and interoceptive network maturation in adolescents. HEP is only an indirect marker for interoceptive processes; therefore, no causality can be implied. Alexithymia self-reports could be critical, as individuals with higher levels of alexithymia exhibit more difficulties in discerning their internal emotional states. Power sensitivity analysis revealed a slightly underpowered sample.

Conclusion

This study suggests altered neuronal processing of bodily signals during interoception in adolescents with higher alexithymia scores. Our findings are novel, as they are the first to exhibit an interaction in this direction, thus highlighting the relevance of interoceptive processing in alexithymia.

述情障碍以情感识别和表达受损为特征，与非典型内感受（感知和处理身体信号的能力）表现出概念和神经解剖学上的重叠。本研究利用心跳诱发电位（一种反映心脏信号处理的大脑反应）调查青少年述情障碍和内感受之间的联系。方法47名健康受试者（平均年龄14.29岁，女性53.2%）在3种条件下（内感受任务、面部情绪识别任务和静息条件）进行HEP记录，并完成多伦多述情障碍量表（TAS-20）。结果内感受性任务中右额中央球HEP活动与TAS-20总分呈负相关。同一区域的HEP与两个TAS-20分量表呈不显著负相关。在其他情况下，述情障碍评分与HEP振幅之间无显著相关性。TAS-20分数与内感受性任务的表现无显著相关性。局限性：由于青少年情绪和内感受网络的持续成熟，对成人的普遍性是有限的。HEP只是内感受过程的一个间接标记；因此，没有因果关系可以隐含。述情障碍自我报告可能是至关重要的，因为述情障碍水平较高的个体在识别自己的内部情绪状态方面表现出更多的困难。功率灵敏度分析显示，样品的功率略低。结论叙述性障碍评分较高的青少年在间感受过程中，身体信号的神经元加工发生了改变。我们的发现是新颖的，因为它们是第一个在这个方向上表现出相互作用的，从而突出了述情障碍中内感受加工的相关性。

{"title":"Atypical automatic processing of interoceptive information in adolescents with alexithymia","authors":"Lorenz Rapp, Sandra A. Mai-Lippold, Eleana Georgiou, Olga Pollatos","doi":"10.1016/j.jadr.2025.100958","DOIUrl":"10.1016/j.jadr.2025.100958","url":null,"abstract":"<div><h3>Background</h3><div>Alexithymia, characterized by impaired emotional identification and expression, exhibits conceptual and neuroanatomical overlap with atypical interoception - the ability to perceive and process bodily signals. This study investigates in adolescents the link between alexithymia and interoception using the heartbeat-evoked potential (HEP), a brain response reflecting cardiac signal processing.</div></div><div><h3>Methods</h3><div>Forty-seven healthy subjects (mean age 14.29 years, 53.2% female) underwent HEP recordings across three conditions (an interoceptive task, facial emotion recognition task, and resting condition) and completed the Toronto Alexithymia Scale (TAS-20).</div></div><div><h3>Results</h3><div>Frontocentral right hemisphere HEP activity during the interoceptive task displayed a negative correlation with TAS-20 total score. The HEP measured in the same area showed a non-significant trend for a negative correlation with two TAS-20 subscales. No significant correlation was observed between alexithymia scores and HEP amplitudes during the other conditions. TAS-20 scores had no significant association with the performance in an interoceptive task.</div></div><div><h3>Limitations</h3><div>Generalizability to adults is limited due to ongoing emotional and interoceptive network maturation in adolescents. HEP is only an indirect marker for interoceptive processes; therefore, no causality can be implied. Alexithymia self-reports could be critical, as individuals with higher levels of alexithymia exhibit more difficulties in discerning their internal emotional states. Power sensitivity analysis revealed a slightly underpowered sample.</div></div><div><h3>Conclusion</h3><div>This study suggests altered neuronal processing of bodily signals during interoception in adolescents with higher alexithymia scores. Our findings are novel, as they are the first to exhibit an interaction in this direction, thus highlighting the relevance of interoceptive processing in alexithymia.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100958"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and influential factors of symptom and medication persistence in children with attention deficit hyperactivity disorder (ADHD) during COVID-19 pandemic COVID-19大流行期间儿童注意缺陷多动障碍（ADHD）症状及服药持久性的患病率及影响因素

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100952

Pongpan Suriyong , Penkarn Kanjanarat , Shih-Hsien Lin , Thawari Khansamrong , Nootjaree Kamduang , Jenwara Pisitsupamitr , Khwandao Sudthanaphan

Background

The COVID-19 pandemic significantly impacted worldwide populations, triggering substantial societal changes and notably affecting children with ADHD's health. This study examined the prevalence and influential factors of ADHD symptoms and medication persistence in children during COVID-19.

Methods

This cross-sectional study at Rajanagarindra Institute of Child Development in Thailand, analyzed ADHD symptom management and medication persistence among children, using administrative data from April 3, 2019, to December 31, 2022. Supplemented by telephone interviews with parents, the study identified responsive and refractory groups, employing the SNAP IV scale and physician assessments for symptom evaluation. Medication persistence was evaluated through the medication possession ratio, dosage adjustments, additional psychiatric medications, and treatment discontinuation exceeding six months post-COVID-19. The study analyzed the influential factors using logistic regression analysis.

Results

During the COVID-19 pandemic, 1864 individuals accessed hospital services, with 90.7 % experiencing poor medication persistence, 33.4 % showing refractory ADHD symptoms, and 27.5 % exhibiting both. Among the 191 subjects (predominantly male), children aged 10–12 and 13–18 demonstrated better medication persistence than those aged 7–9, with aOR = 2.44 (95 % CI: 1.23–4.85; P = 0.011) and 4.55 (95 % CI: 1.84–11.28; P = 0.001), respectively. Symptom-responsive children with sustained medication persistence had improved hospital access compared to the refractory group (aOR = 0.43; 95 % CI: 0.19–0.98; P = 0.045). Additionally, 17.3 % reported adverse drug events.

Conclusion

During COVID-19, Thai children with ADHD struggled with severe symptoms and medication persistence, influenced by age and hospital access; telehealth and telepharmacy could offer support.

2019冠状病毒病大流行严重影响了全球人口，引发了重大的社会变化，尤其影响了多动症儿童的健康。本研究调查了COVID-19期间儿童ADHD症状的患病率及其影响因素和药物持久性。方法泰国Rajanagarindra儿童发展研究所的这项横断面研究，使用2019年4月3日至2022年12月31日的行政数据，分析了儿童ADHD症状管理和药物持久性。通过与家长的电话访谈，研究确定了反应组和难治组，采用SNAP IV量表和医生评估进行症状评估。通过药物持有率、剂量调整、额外的精神科药物和covid -19后超过6个月的治疗停药来评估药物持久性。本研究采用logistic回归分析对影响因素进行分析。结果在2019冠状病毒病大流行期间，有1864人就诊，其中90.7%的人出现服药持久性差，33.4%的人出现难治性ADHD症状，27.5%的人两者兼有。191名被试（以男性为主）中，10-12岁和13-18岁儿童的服药持久性优于7-9岁儿童，aOR = 2.44 (95% CI: 1.23-4.85；P = 0.011)和4.55 (95% CI: 1.84-11.28；P = 0.001)。与难治性组相比，持续服药的症状反应性儿童的住院率更高(aOR = 0.43；95% ci: 0.19-0.98；P = 0.045)。此外，17.3%的人报告了药物不良事件。结论在2019冠状病毒病疫情期间，泰国ADHD患儿表现出严重的症状和服药持久性，受年龄和医院就诊情况的影响；远程保健和远程药房可以提供支持。

{"title":"Prevalence and influential factors of symptom and medication persistence in children with attention deficit hyperactivity disorder (ADHD) during COVID-19 pandemic","authors":"Pongpan Suriyong , Penkarn Kanjanarat , Shih-Hsien Lin , Thawari Khansamrong , Nootjaree Kamduang , Jenwara Pisitsupamitr , Khwandao Sudthanaphan","doi":"10.1016/j.jadr.2025.100952","DOIUrl":"10.1016/j.jadr.2025.100952","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic significantly impacted worldwide populations, triggering substantial societal changes and notably affecting children with ADHD's health<em>.</em> This study examined the prevalence and influential factors of ADHD symptoms and medication persistence in children during COVID-19.</div></div><div><h3>Methods</h3><div>This cross-sectional study at Rajanagarindra Institute of Child Development in Thailand, analyzed ADHD symptom management and medication persistence among children, using administrative data from April 3, 2019, to December 31, 2022. Supplemented by telephone interviews with parents, the study identified responsive and refractory groups, employing the SNAP IV scale and physician assessments for symptom evaluation. Medication persistence was evaluated through the medication possession ratio, dosage adjustments, additional psychiatric medications, and treatment discontinuation exceeding six months post-COVID-19. The study analyzed the influential factors using logistic regression analysis.</div></div><div><h3>Results</h3><div>During the COVID-19 pandemic, 1864 individuals accessed hospital services, with 90.7 % experiencing poor medication persistence, 33.4 % showing refractory ADHD symptoms, and 27.5 % exhibiting both. Among the 191 subjects (predominantly male), children aged 10–12 and 13–18 demonstrated better medication persistence than those aged 7–9, with aOR = 2.44 (95 % CI: 1.23–4.85; <em>P</em> = 0.011) and 4.55 (95 % CI: 1.84–11.28; <em>P</em> = 0.001), respectively. Symptom-responsive children with sustained medication persistence had improved hospital access compared to the refractory group (aOR = 0.43; 95 % CI: 0.19–0.98; <em>P</em> = 0.045). Additionally, 17.3 % reported adverse drug events.</div></div><div><h3>Conclusion</h3><div>During COVID-19, Thai children with ADHD struggled with severe symptoms and medication persistence, influenced by age and hospital access; telehealth and telepharmacy could offer support.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100952"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0