Journal of Affective Disorders Reports最新文献_第5页

Corrigendum to “Machine learning prediction of psychological resilience: An analysis of health and self-perception variables” [Journal of Affective Disorders Reports, Volume 23 (January 2026) 1-9 101000] “心理弹性的机器学习预测：健康和自我感知变量的分析”的勘误表[情感障碍报告杂志，第23卷（2026年1月）1-9 101000]

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2026-01-14 DOI: 10.1016/j.jadr.2025.101015

Javier Díaz Esteban-Herreros , Miriam Garrido-Miguel , Vicente Martínez-Vizcaíno , Ana Isabel Torres-Costoso , Asunción Ferri-Morales , Igor Cigarroa , Juan Moreno-García , Elizabeth Bravo-Esteban

引用次数: 0

Developing and evaluating a questionnaire to assess personal recovery experiences in older people with bipolar disorder 开发和评估问卷，以评估老年双相情感障碍患者的个人康复经验

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.jadr.2025.101005

Jennifer Matthewson , Steven Jones , Gillian Haddock , Elizabeth Tyler

Background

Despite evidence that the mental health experiences of older adults are qualitatively different to those of younger adults, little research has investigated the recovery preferences of people aged 60 years and over (Chen et al., 2027). This paper presents the first measure of personal recovery developed specifically for older adults with bipolar disorder (BD).

Methods

Collaboration with older adults who had lived experience of BD, clinicians and academics supported the development of the Bipolar Recovery Questionnaire for Older Adults (BRQ-OA). A total of 55 participants aged 60+ (mean=66.98, SD=8.19) with a diagnosis of BD completed the BRQ-OA alongside symptom and quality of life measures. The BRQ-OA was completed again four weeks later. It was hypothesised that the BRQ-OA would be a reliable and valid measure of personal recovery.

Results

The BRQ-OA had good internal consistency, and scores were reliable over a 4-week period. Scores on the BRQ-OA were significantly associated with lower depression and mania scores and higher scores on quality of life and functioning measures.

Limitations

Small sample size restricted understanding of factors underlying the BRQ-OA. Participants were primarily White British with high levels of education, therefore generalisability to other groups is unclear.

Conclusions

Findings indicate the BRQ-OA is a reliable and valid measure of personal recovery for older adults with BD. Scores are significantly associated with factors commonly defined as part of personal recovery. This is the first mental health measure designed with and for older adults to support the use of recovery-focused approaches in clinical practice and research.

尽管有证据表明老年人的心理健康经历与年轻人有质的不同，但很少有研究调查60岁及以上人群的康复偏好（Chen et al., 2027）。本文提出了个人康复的第一个措施开发专门为老年人双相情感障碍（BD）。方法与有双相障碍生活经历的老年人、临床医生和学者合作，支持开发老年人双相障碍康复问卷（BRQ-OA）。共有55名60岁以上（平均66.98，SD=8.19）诊断为双相障碍的参与者完成了BRQ-OA以及症状和生活质量测量。四周后再次完成BRQ-OA。假设BRQ-OA是一种可靠有效的个人康复测量方法。结果BRQ-OA具有良好的内部一致性，评分在4周内可靠。BRQ-OA得分与抑郁和躁狂症得分较低以及生活质量和功能测量得分较高显著相关。局限性：样本量小限制了对BRQ-OA潜在因素的理解。参与者主要是受过高等教育的英国白人，因此对其他群体的普遍性尚不清楚。结论：研究结果表明，BRQ-OA是一种可靠有效的老年双相障碍患者个人恢复的测量方法。得分与通常定义为个人恢复部分的因素显着相关。这是第一个为老年人设计的心理健康措施，以支持在临床实践和研究中使用以康复为重点的方法。

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引用次数: 0

Evaluation of the psychometric properties of patient-reported outcome measures for adolescent depression: A COSMIN systematic review 评估青少年抑郁症患者报告结果测量的心理测量特性：COSMIN系统综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jadr.2025.100993

Christopher J. Rikard-Bell , Justin Botros , Caroline Hunt , Philippa Hay , Michelle Cunich , Stephen Touyz

Objectives

This review evaluated the quality and suitability of current Patient-Reported Outcome Measures for measuring depressive symptoms and diagnosing depression in adolescents, including whether there is any measurement of potential developmental aetiological factors.

Methods

On August 8, 2024, the databases Web of Science, PsycINFO, Scopus, and Ovid Medline were searched for studies on psychometric instruments designed to detect adolescent depressive symptoms. Two reviewers searched for relevant articles, extracted data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and assessed the quality of studies and instruments using the 2018 and 2024 Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines for the systematic review of Patient-Reported Outcome Measures. Additional evaluation of instrument content assessed whether items addressed developmental aetiology. PROSPERO CRD42020175950.

Results

57 publications met the inclusion criteria, identifying 16 instruments for quality assessment. Most instruments for measuring adolescent depressive symptoms were adaptations of adult depression scales based on adult diagnostic criteria. According to COSMIN criteria, three instruments - the BDI-2, MFQ, and PHQ - received an A rating, 12 a B rating, and one a C rating, based on the quality of evidence for their measurement properties. None of the instruments directly assessed developmental aetiological factors.

Conclusion

While some high-quality psychometric instruments are available for identifying adolescent depressive symptoms, further development of psychometric instruments is needed to incorporate potential aetiological factors relevant to adolescent development in the context of depressive symptoms.

Systematic review registration

CRD42020175950.

目的：本综述评估了目前用于测量青少年抑郁症状和诊断抑郁的患者报告结局指标的质量和适用性，包括是否有任何潜在发育病因的测量。方法于2024年8月8日检索Web of Science、PsycINFO、Scopus和Ovid Medline等数据库，检索用于检测青少年抑郁症状的心理测量工具的相关研究。两位审稿人检索相关文章，按照系统评价和荟萃分析指南的首选报告项目提取数据，并使用2018年和2024年基于共识的健康测量工具选择标准（COSMIN）患者报告结果测量系统评价指南评估研究和工具的质量。仪器内容的附加评估评估项目是否涉及发育病因。普洛斯彼罗CRD42020175950。结果57篇文献符合纳入标准，确定了16种质量评价工具。大多数测量青少年抑郁症状的工具是根据成人诊断标准改编的成人抑郁量表。根据COSMIN标准，三个仪器——BDI-2、MFQ和PHQ——根据其测量特性的证据质量获得A级，12个为B级，1个为C级。没有一种工具直接评估发育病因。结论虽然有一些高质量的心理测量工具可用于青少年抑郁症状的识别，但需要进一步开发心理测量工具，以纳入抑郁症状背景下与青少年发展相关的潜在病因学因素。系统评价注册号crd42020175950。

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引用次数: 0

Persistent suicidality: A systematic scoping review of the literature 持续性自杀：系统的文献综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1016/j.jadr.2025.100996

Mette M. Palm , Elke Elzinga , Leah Middelkoop , Almar A.L. Kok , Kairi Kõlves , Aartjan T.F. Beekman , Sisco M.P. van Veen

Background

Suicidality can extend beyond the acute phase and be a long-term condition. Known by various terms, including chronic or persistent suicidality (PS), this phenomenon is well recognized in clinical practice. However, a comprehensive synthesis and evaluation of the literature is missing, leaving the scope and focus of the current scientific evidence on PS unclear.

Aims

This review aims to identify and critically appraise the literature on PS. It seeks to provide an overview of how the evidence defines and operationalises PS, its occurrence, and the characteristics of individuals affected by it.

Method

A systematic scoping review was conducted following the PRISMA-ScR guidelines. After preregistration, searches were conducted in six databases: Embase, PubMed, APA PsycInfo, Web of Science, Scopus, and ERIC. Articles describing individuals with suicidal ideation or a death wish lasting a year or longer were included. Quality appraisal was performed using the National Institute of Health's quality assessment tools. Due to the pluriformity of the literature a narrative synthesis was conducted.

Results

In total, 63 articles met the criteria for inclusion. Around one-third of individuals experience suicidal ideation that persist over the long term. There is a strong overall association between PS and psychiatric or psychological distress. Results suggest that specific variables may help differentiate between individuals with transient suicidal ideation and those at risk for PS.

Conclusions

Despite sufficient quality of most studies reporting PS, the field is hindered by inconsistent operationalisations and a lack of study replication. This study highlights the need for a uniform understanding of PS and proposes a provisional definition.

背景：自杀倾向可以延续到急性期之后，成为一种长期的状态。这一现象在临床实践中得到了广泛的认可，包括慢性或持续性自杀（PS）。然而，缺乏对文献的全面综合和评估，使得目前关于PS的科学证据的范围和重点不明确。本综述旨在识别和批判性地评估关于PS的文献。它旨在概述证据如何定义和操作PS，其发生以及受其影响的个体特征。方法按照PRISMA-ScR指南进行系统的范围审查。预注册后，在六个数据库中进行检索：Embase、PubMed、APA PsycInfo、Web of Science、Scopus和ERIC。文章描述个人自杀意念或死亡愿望持续一年或更长时间。使用国家卫生研究院的质量评估工具进行质量评估。由于文学作品的多样性，进行了叙事综合。结果共有63篇文章符合纳入标准。大约三分之一的人有过长期存在的自杀念头。PS和精神或心理困扰之间有很强的整体联系。结果表明，特定的变量可能有助于区分有短暂自杀意念的个体和有PS风险的个体。结论尽管大多数报告PS的研究质量足够高，但该领域受到不一致的操作和缺乏研究复制的阻碍。这项研究强调了对PS有统一理解的必要性，并提出了一个临时定义。

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引用次数: 0

Sequential esketamine and dextromethorphan-bupropion in treatment-resistant depression with bipolar features: A case report 序贯艾氯胺酮和右美沙芬-安非他酮治疗伴有双相特征的难治性抑郁症1例

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1016/j.jadr.2025.100994

Neekoo Farahmandpour , Fatma Wafy , Jeffrey Feola

Treatment-resistant depression (TRD) remains a major clinical challenge, particularly in patients with bipolar spectrum features where standard antidepressants often fail. Novel glutamatergic and sigma-1 receptor–modulating agents such as intranasal esketamine and dextromethorphan-bupropion (Auvelity) offer promising alternatives. We report the case of a 43-year-old male with recurrent depression and bipolar II features who had failed eight antidepressant and mood-stabilizing trials over two decades. A four-week course of intranasal esketamine at Kings County Hospital Center produced marked improvement, with remission lasting approximately six months. After relapse, treatment with dextromethorphan-bupropion led to renewed and sustained recovery without mania or hypomania. This sequential response suggests esketamine may serve as an induction treatment, with dextromethorphan-bupropion providing a feasible maintenance option in TRD with bipolar features. The case highlights the importance of recognizing bipolarity in treatment-resistant presentations and demonstrates the potential of sequential glutamatergic and sigma-1 receptor–modulating therapies when long-term esketamine is impractical. Controlled studies are warranted to identify predictors of response, long-term safety, and optimal treatment sequencing.

难治性抑郁症（TRD）仍然是一个主要的临床挑战，特别是在双相情感障碍患者中，标准抗抑郁药往往失效。新型谷氨酸能和sigma-1受体调节剂如鼻用艾氯胺酮和右美沙芬-安非他酮（Auvelity）提供了有希望的替代药物。我们报告一例43岁男性复发性抑郁症和双相情感障碍II特征，他在20年的抗抑郁和情绪稳定试验中失败了8次。在金斯县医院中心进行了为期四周的鼻内艾氯胺酮治疗，效果明显改善，缓解期持续约6个月。复发后，用右美沙芬-安非他酮治疗可使患者恢复并持续恢复，无躁狂症或轻躁症。这种顺序反应表明艾氯胺酮可以作为诱导治疗，右美沙芬-安非他酮为双相特征的TRD提供了可行的维持选择。该病例强调了在治疗抗性表现中识别双极性的重要性，并证明了在长期艾氯胺酮不切实际时，顺序谷氨酸能和sigma-1受体调节治疗的潜力。有必要进行对照研究，以确定反应、长期安全性和最佳治疗顺序的预测因素。

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引用次数: 0

Inflammatory markers mediate the association between depression and all-cause mortality: Evidence from NHANES 2007–2018 炎症标志物介导抑郁症和全因死亡率之间的关联：来自NHANES 2007-2018的证据

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1016/j.jadr.2025.101010

Yuehua Fei, Wei Yang, Yong Liu, Yanmei Yu, Tongcai Tan

Objective

Depressive symptoms are linked to increased all-cause mortality, but the biological mechanisms remain unclear. This study investigated whether systemic inflammatory markers—white blood cell count (WBC) and red cell distribution width (RDW)—mediate the association between depression and mortality in U.S. adults.

Methods

Data from 13,061 participants in the 2007–2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Cox proportional hazards models examined the association between depressive symptoms and all-cause mortality. Mediation analyses evaluated indirect effects of WBC and RDW.

Results

In fully adjusted models, severe depressive symptoms (PHQ-9 ≥15) were associated with higher mortality risk (HR = 2.18; 95 % CI: 1.17–4.09; p < 0.001). Depression scores were positively correlated with WBC (β = 0.33) and RDW (β = 0.21). Elevated WBC and RDW levels independently predicted increased mortality (WBC HR = 1.37; RDW HR = 2.53). Mediation analyses indicated WBC and RDW explained 12.2 % and 30.8 % of the total effect of depression on mortality, respectively.

Conclusions

Depressive symptoms are significantly associated with higher all-cause mortality, partially mediated by systemic inflammation. RDW, in particular, may reflect chronic inflammatory burden linked to depression. These findings highlight the value of monitoring inflammatory markers in depression management to mitigate long-term mortality risk.

目的：抑郁症状与全因死亡率增加有关，但其生物学机制尚不清楚。本研究调查了系统性炎症标志物——白细胞计数（WBC）和红细胞分布宽度（RDW）——是否介导了美国成年人抑郁和死亡率之间的关联。方法对2007-2018年全国健康与营养检查调查（NHANES） 13061名参与者的数据进行分析。使用患者健康问卷-9 （PHQ-9）评估抑郁症。Cox比例风险模型检验了抑郁症状与全因死亡率之间的关系。中介分析评估了WBC和RDW的间接影响。结果在完全调整后的模型中，重度抑郁症状（PHQ-9≥15）与较高的死亡风险相关（HR = 2.18; 95% CI: 1.17-4.09; p < 0.001）。抑郁评分与WBC （β = 0.33）、RDW （β = 0.21）呈正相关。WBC和RDW水平升高独立预测死亡率增加（WBC HR = 1.37; RDW HR = 2.53）。中介分析表明，WBC和RDW分别解释了抑郁症对死亡率总影响的12.2%和30.8%。结论抑郁症状与高全因死亡率显著相关，部分由全身性炎症介导。RDW尤其可能反映与抑郁症相关的慢性炎症负担。这些发现强调了监测炎症标志物在抑郁症管理中降低长期死亡风险的价值。

{"title":"Inflammatory markers mediate the association between depression and all-cause mortality: Evidence from NHANES 2007–2018","authors":"Yuehua Fei, Wei Yang, Yong Liu, Yanmei Yu, Tongcai Tan","doi":"10.1016/j.jadr.2025.101010","DOIUrl":"10.1016/j.jadr.2025.101010","url":null,"abstract":"<div><h3>Objective</h3><div>Depressive symptoms are linked to increased all-cause mortality, but the biological mechanisms remain unclear. This study investigated whether systemic inflammatory markers—white blood cell count (WBC) and red cell distribution width (RDW)—mediate the association between depression and mortality in U.S. adults.</div></div><div><h3>Methods</h3><div>Data from 13,061 participants in the 2007–2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Cox proportional hazards models examined the association between depressive symptoms and all-cause mortality. Mediation analyses evaluated indirect effects of WBC and RDW.</div></div><div><h3>Results</h3><div>In fully adjusted models, severe depressive symptoms (PHQ-9 ≥15) were associated with higher mortality risk (HR = 2.18; 95 % CI: 1.17–4.09; <em>p</em> < 0.001). Depression scores were positively correlated with WBC (β = 0.33) and RDW (β = 0.21). Elevated WBC and RDW levels independently predicted increased mortality (WBC HR = 1.37; RDW HR = 2.53). Mediation analyses indicated WBC and RDW explained 12.2 % and 30.8 % of the total effect of depression on mortality, respectively.</div></div><div><h3>Conclusions</h3><div>Depressive symptoms are significantly associated with higher all-cause mortality, partially mediated by systemic inflammation. RDW, in particular, may reflect chronic inflammatory burden linked to depression. These findings highlight the value of monitoring inflammatory markers in depression management to mitigate long-term mortality risk.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 101010"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI: 10.1016/j.jadr.2025.100982

Thitiworn Choosong , Jukkrit Wungrath , Kanthee Anantapong , Nuha Masapha , Nunnapat Chintanavisit , Phawin Thitasomkun , Sataphol Klayaksorn , Saran Thongsri , Asmee Ekakkaraphibal , Keeratikorn Kittipol , Chanikarn Kaewfaeg , Ratanaporn Chootong

Introduction

Depression incidence and lifestyle factors, especially breakfast consumption, are associated with both mental and physical well-being among medical students. To promote the well-being of medical students, the relationship between depression levels and skipping breakfast was investigated in 1st- to 6th-year medical students.

Methods

Our cross-sectional study was conducted between June and October 2023. We assessed breakfast quality and skipping breakfast using a questionnaire of breakfast behaviour and the Thai versions of both the 9-item Patient Health Questionnaire and the Pittsburgh Sleep Quality Index. Multiple and ordinal logistic regression analyses were performed to identify significant factors related to depression and skipping breakfast.

Results

In this study, participants were medical students (n = 256), among which 39.8 % were male and 60.2 % female; the prevalence of depression and skipping breakfast was 12.11 % and 72.27 %, respectively. Skipping breakfast was significantly associated with breakfast quality (p-value < 0.001), but not depression levels. Older students (OR = 1.19, 95 % CI [1.02, 1.39], p-value < 0.026); poor quality of breakfast (OR = 3.04, 95 % CI [1.66, 5.58], p-value < 0.001); and not living at home were significantly linked to skipping breakfast. Depression levels were associated with being female, poor sleep quality, family history of psychological disorders, and living in dormitories. However, age was found to be a significant protective factor against depression.

Conclusions

Breakfast quality, sleep quality, current accommodation, and family history of psychological disorders should be considered to promote the improvement of medical students’ mental health.

医学生的抑郁发生率和生活方式因素，尤其是早餐消费，与心理和身体健康都有关系。为了提高医学生的幸福感，本研究以一至六年级医学生为研究对象，调查抑郁水平与不吃早餐的关系。方法于2023年6月- 10月进行横断面研究。我们使用早餐行为问卷和泰国版的9项患者健康问卷和匹兹堡睡眠质量指数来评估早餐质量和不吃早餐。采用多元和有序logistic回归分析确定抑郁与不吃早餐相关的显著因素。结果研究对象为医学生256人，其中男性占39.8%，女性占60.2%；抑郁和不吃早餐的患病率分别为12.11%和72.27%。不吃早餐与早餐质量显著相关（p值<； 0.001），但与抑郁水平无关。大龄学生（OR = 1.19, 95% CI [1.02, 1.39]， p值<； 0.026）；早餐质量差（OR = 3.04, 95% CI [1.66, 5.58]， p值<； 0.001）；不住在家里与不吃早餐有很大关系。抑郁程度与女性、睡眠质量差、心理障碍家族史和住在宿舍有关。然而，年龄被发现是防止抑郁的重要保护因素。结论应综合考虑早餐质量、睡眠质量、当前住宿、心理障碍家族史等因素，促进医学生心理健康状况的改善。

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引用次数: 0

Antenatal depressive and anxiety symptoms in women with eating disorders who continue or discontinue antidepressant treatment in pregnancy 怀孕期间继续或停止抗抑郁治疗的饮食失调妇女的产前抑郁和焦虑症状

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-01 Epub Date: 2025-10-12 DOI: 10.1016/j.jadr.2025.100985

Milica Zugic , Nhung TH Trinh , Sina Rostami , Hedvig Nordeng , Eivind Ystrom , Cynthia M Bulik , Øyvind Rø , Ole A. Andreassen , Per Magnus , Angela Lupattelli

Background

Limited evidence on antidepressant effectiveness in pregnant women with eating disorders (ED) challenges pharmacotherapy management. We examined antenatal depressive and anxiety symptoms with continued antidepressant use in women with ED.

Methods

We used data from the Norwegian Mother, Father and Child Cohort Study (MoBa) linked to the Medical Birth Registry of Norway and MoBa Genetics. MoBa questionnaires at weeks 17 (early) and 30 (mid-late pregnancy) measured antidepressant exposure and symptoms of depression and anxiety using the 5-item Hopkins Symptom Checklist. We fitted generalised linear models and adjusted for confounding. In a subsample, we stratified analyses by polygenic-score tertiles for antidepressant response.

Results

We identified 5920 pregnancies in women with ED, mainly binge-eating disorder (BED) (84.0 %) and bulimia nervosa (BN) (12.4 %). Of these, 48 (0.8 %) continued antidepressants into early pregnancy, 93 (1.6 %) discontinued during, and 85 (1.4 %) discontinued before pregnancy. At early pregnancy only, continued antidepressant was associated with lower severity of depressive and anxiety symptoms relative to discontinuation. Among women with BED, this was specific to lower anxiety symptoms (β:-0.43, 95 %CI:-0.84, -0.02). This association was not observed in women with BN. In women with higher antidepressant-response polygenic-score continued antidepressant was associated with lower symptom severity relative to discontinued (range of β:-0.86 to -1.35).

Conclusions

Continuing antidepressants in early but not mid-late pregnancy is associated with lower severity of depressive and anxiety symptoms in women with BED. The association observed in women with higher antidepressant-response polygenic-score calls for larger studies on personalized treatment in perinatal ED.

背景：关于饮食失调孕妇抗抑郁药有效性的有限证据对药物治疗管理提出了挑战。我们检查了ed妇女持续使用抗抑郁药的产前抑郁和焦虑症状。方法我们使用挪威母亲、父亲和儿童队列研究（MoBa）的数据，该研究与挪威医学出生登记处和MoBa遗传学相关联。妊娠第17周（妊娠早期）和第30周（妊娠中后期）的MoBa问卷使用5项霍普金斯症状检查表测量抗抑郁药物暴露和抑郁、焦虑症状。我们拟合了广义线性模型并对混杂因素进行了调整。在一个亚样本中，我们通过多基因得分分位数对抗抑郁反应进行分层分析。结果5920例妊娠ED患者，主要为暴食症（BED）（84.0%）和神经性贪食症（BN）（12.4%）。其中，48人（0.8%）在怀孕早期继续服用抗抑郁药物，93人（1.6%）在怀孕期间停用，85人（1.4%）在怀孕前停用。仅在妊娠早期，持续服用抗抑郁药与停药相比，抑郁和焦虑症状的严重程度较低。在患有BED的女性中，这是特定于较低的焦虑症状（β:-0.43, 95% CI:-0.84, -0.02）。这种关联在BN女性中未观察到。在抗抑郁反应多基因评分较高的女性中，持续服用抗抑郁药与停用抗抑郁药相比，症状严重程度较低（β范围：-0.86至-1.35）。结论妊娠早期而非中晚期持续服用抗抑郁药物与BED患者抑郁和焦虑症状的严重程度较低有关。在抗抑郁反应多基因评分较高的妇女中观察到的关联要求对围产期ED的个性化治疗进行更大规模的研究。

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引用次数: 0

Erratum regarding previously published articles 关于以前发表的文章的勘误

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-01 Epub Date: 2025-07-14 DOI: 10.1016/j.jadr.2025.100942

引用次数: 0

A prospective cohort study on changes in psychosocial distress and preterm birth among pregnant Pakistani women 巴基斯坦孕妇社会心理困扰与早产变化的前瞻性队列研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-01 Epub Date: 2025-08-19 DOI: 10.1016/j.jadr.2025.100964

Salima Sulaiman , Aliyah Dosani , Ilona S. Yim , Sharifa Lalani , Ntonghanwah Forcheh , Shahirose Sadrudin Premji , Maternal-infant Global Health Team (MiGHT)—Collaborators in Research

Changes in mental health during pregnancy may better predict preterm birth (PTB) as assessment at one time point are inconsistently associated with this outcome. Our prospective cohort study of 1225 pregnant Pakistani women determined whether (a) changes in psychosocial distress (i.e., pregnancy-related anxiety, state anxiety, depressive symptoms) between 10 and 19 and 22 to 29 weeks’ gestational age influenced the risk of PTB; and (b) social determinants of health and chronic stress influenced this relationship. The individual effect of changes in (a) pregnancy-related anxiety on PTB was significant only among women with low social support from family (OR = 0.85, 95 % CI 0.74–0.97, p = 0.017); and (b) depressive symptoms on PTB were significantly modified by education (p = 0.011), number of previous children (p = 0.028) and life-time interpersonal trauma (p = 0.073). The average aggregate change score was associated with PTB among women with low family support (OR = 0.79, 95 % CI 0.67–0.93, p = 0.005), after adjusting for confounders. The collective effect, assessed using multiple logistic regression, was not significant. Chronic stress did not alter any findings. An intersectional approach will enable exploration of the disparate burden of psychosocial distress during pregnancy on PTB.

怀孕期间心理健康的变化可能更好地预测早产（PTB），因为在一个时间点的评估与这一结果的相关性不一致。我们对1225名巴基斯坦孕妇进行了前瞻性队列研究，以确定(a)胎龄在10 - 19周和22 - 29周之间的心理社会困扰（即妊娠相关焦虑、状态焦虑、抑郁症状）的变化是否影响PTB的风险；(b)健康和慢性压力的社会决定因素影响了这种关系。(a)妊娠相关焦虑变化对肺结核的个体影响仅在家庭社会支持较低的妇女中显著（OR = 0.85, 95% CI 0.74-0.97, p = 0.017）；(b)受教育程度（p = 0.011）、既往子女数量（p = 0.028）和终生人际创伤（p = 0.073）显著改善肺结核患者的抑郁症状。在调整混杂因素后，家庭支持度低的妇女的平均总变化得分与PTB相关（OR = 0.79, 95% CI 0.67-0.93, p = 0.005）。使用多元逻辑回归评估的集体效应不显著。慢性压力没有改变任何发现。交叉方法将使探索不同负担的心理社会困扰怀孕期间对肺结核。

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引用次数: 0