Journal of Affective Disorders Reports最新文献_第3页

Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study 锂能减少自杀未遂复发高风险跨诊断患者的冲动决策：随机、双盲、安慰剂对照、交叉研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100833

Nicholas Murphy , Grace Pham , Andreas Weyland , Julia Engelhardt , George Kypriotakis , Ynhi T. Thomas , Thomas R. Kosten , Nidal Moukaddam , Sanjay J. Mathew , Alan C. Swann

Background

Studies attempting to distinguish suicide attempters from ideators have found that impulsivity is consistently associated with attempts across the spectrum of suicidal behavior from self-harm to lethal suicidal behavior. Impulsivity is readily assessed using complementary clinical and laboratory measures, making it a viable target for pharmacological strategies to prevent suicide risk. Lithium reduces suicidal behavior across diagnoses, and has been implicated in the reduction of impulsivity triggered by stress mediated phosphatidylinositol turnover. We used a placebo controlled cross-over design to study the effects of repeated lithium dosing on risk factors predisposing to suicidal behavior.

Methods

15 patients with a recent (past year) medically severe suicide attempt (MSSA) (37.5% male, 40.13 ± 13.66 years) received lithium carbonate and matching pill placebo separately in a randomized double-blind crossover design administered six weeks apart. To test the effect of lithium on measures of impulsivity and arousal, participants completed the Immediate Memory Task (IMT), Internal State Scale (ISS), and the Time Perception Task (TPT). We conducted separate analyses for each variable using repeated measures analysis of covariance.

Results

Lithium dosing was associated with increased IMT response latency (p = .017, pη² = 0.23), and decision bias (p = .048, pη2 = 0.21). Lithium did not significantly alter time perception or activation.

Conclusions

Our results suggest that lithium may reduce risk in MSSA survivors by increasing the response latency and increasing conservative response bias during decision-making. Future studies should conduct long-term follow-ups with adjunct behavioral therapy with lithium on factors contributing to suicidal behavior.

背景试图将自杀企图者与意念自杀者区分开来的研究发现，从自残到致命的自杀行为，冲动性一直与自杀企图有关。冲动性很容易通过互补的临床和实验室测量方法进行评估，因此成为预防自杀风险的药物策略的可行目标。锂能减少各种诊断中的自杀行为，并与减少由压力介导的磷脂酰肌醇周转所引发的冲动性有关。我们采用安慰剂对照交叉设计，研究重复服用锂剂对易导致自杀行为的风险因素的影响。方法15名近期（过去一年）有严重自杀企图（MSSA）的患者（37.5%为男性，40.13 ± 13.66岁）在随机双盲交叉设计中分别接受碳酸锂和匹配药片安慰剂治疗，间隔时间为6周。为了测试锂对冲动和唤醒的影响，参与者完成了即时记忆任务（IMT）、内部状态量表（ISS）和时间感知任务（TPT）。我们使用重复测量的协方差分析方法对每个变量进行了单独分析。结果锂剂量与即时记忆任务反应延迟（p = .017，pη2 = 0.23）和决策偏差（p = .048，pη2 = 0.21）的增加有关。结论我们的研究结果表明，锂可通过增加反应潜伏期和决策过程中的保守反应偏差来降低 MSSA 幸存者的风险。未来的研究应针对导致自杀行为的因素，通过锂辅助行为疗法进行长期随访。

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引用次数: 0

The role of early maladaptive schemas in late adolescents suffering from school burnout and depressive symptoms 早期适应不良图式在晚期青少年学业倦怠和抑郁症状中的作用

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100815

Annelies Van Royen, Laura Wante, Caroline Braet

Background

The present study aims to distinguish school burnout from depressive symptoms in late adolescents between 17 and 21 years old by exploring their underlying early maladaptive schemas (EMS).

Methods

The cross-sectional sample (T1) consisted of 514 secondary and higher education students between 17 and 21 years old (M_age = 19.06 (1.10), 80.9% female). Five months later (T2), 190 adolescents participated in the follow-up measurement (M_age = 19.45 (1.18), 81.6% female).

Results

Positive correlations were found between all EMS and school burnout symptoms. When controlling for school burnout symptoms at T1, only the EMS `emotional deprivation', `mistrust', `defectiveness', `social isolation', `failure', `enmeshment', and `emotional inhibition' displayed significant positive associations with school burnout at T2. The EMS `mistrust', `defectiveness' and `failure' showed relations to both school burnout and depressive symptoms. Backwards linear regressions showed that the EMS `vulnerability to harm/illness' and `insufficient self-control' were uniquely related to school burnout symptoms when controlling for depressive symptoms, while the EMS `dependence', `emotional deprivation', `self-sacrifice' and `unrelenting standards' were uniquely related to depressive symptoms while controlling for school burnout symptoms.

Limitations

The gender-unbalanced sample, reduced longitudinal sample size, sole use of self-report measures, and high comorbidity between school burnout and depressive symptoms may have hampered the results.

Conclusions

EMS play an important role in the development of school burnout symptoms. The results point towards transdiagnostic cognitive-focused treatment techniques with attention to disorder-specific schemas to tackle school burnout symptoms. More (longitudinal) research is needed to corroborate these initial findings.

背景本研究旨在通过探究17至21岁晚期青少年潜在的早期适应不良模式（EMS），将学校倦怠与抑郁症状区分开来。方法横断面样本（T1）由514名17至21岁的中学生和大学生组成（年龄=19.06（1.10），女性占80.9%）。五个月后（T2），190 名青少年参加了跟踪测量（年龄= 19.45 (1.18)，81.6%为女性）。结果发现，所有 EMS 与学校倦怠症状之间存在正相关。在控制了T1阶段的学校倦怠症状后，只有EMS中的 "情感匮乏"、"不信任"、"缺陷"、"社会孤立"、"失败"、"压力 "和 "情感抑制 "与T2阶段的学校倦怠有显著的正相关。教育管理系统中的 "不信任"、"缺陷 "和 "失败 "与学校倦怠和抑郁症状都有关系。反向线性回归表明，在控制抑郁症状的情况下，教育管理系统中的 "易受伤害/疾病 "和 "自我控制能力不足 "与学校倦怠症状有独特的关系，而在控制学校倦怠症状的情况下，教育管理系统中的 "依赖"、"情感剥夺"、"自我牺牲 "和 "不懈标准 "与抑郁症状有独特的关系。局限性样本性别不平衡、纵向样本数量减少、仅使用自我报告测量方法以及学校倦怠和抑郁症状之间的高度合并可能会影响研究结果。研究结果表明，以跨诊断认知为重点的治疗技术可以解决学校倦怠症状，并关注特定障碍的图式。还需要更多的研究（纵向研究）来证实这些初步发现。

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引用次数: 0

The chain mediating role of stress and resilience in the relationship between anxiety sensitivity and depressive symptoms among Chinese college students 压力和复原力在中国大学生焦虑敏感与抑郁症状关系中的连锁中介作用

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100821

Mengjie Cui , Xia Ma , Liyuan Tian , Wenfeng Xu , Hongliang Dai

Background

College is a high-risk period for depressive symptoms. Anxiety sensitivity (AS) is a major predictor of depressive symptoms during college years, but the specific mechanisms remain unclear. This study investigated the relationship using a chain mediation model.

Methods

A sample of 1261 eligible students (mean age of 20.20 ± 1.37 years) residing in Liaoning Province, located in the northeastern part of China, were selected through a convenient sampling method for the purpose of carrying out a comprehensive survey. The self-report questionnaires used in the study encompassed a range of parameters, including the general information questionnaire, anxiety sensitivity index-3 (ASI-3), resilience scale-14 (RS-14), depression, anxiety, and stress scale (DASS-21). Pearson correlation analysis, structural equation model testing, and Bootstrap deviation correction percentile analysis were employed to analyze the survey data using the R 4.3.2 statistical software.

Results

The total AS score and its three lower-order dimensions were positively correlated with stress and depressive symptoms. Resilience was negatively correlated with AS, stress and depressive symptoms. In addition to the direct influence of AS on depressive symptoms, stress and resilience play a partial mediating role in the relationship between AS physical and cognitive concerns and depressive symptoms, the total indirect effects accounted for 91.5 % and 92.1 %, respectively, and fully mediate the relationship between AS social concerns and depressive symptoms.

Conclusions

The study's outcomes indicate that practical actions can be taken to decrease AS and stress, thereby enhancing resilience and reducing depressive symptoms in adolescents.

背景大学时期是抑郁症状的高危期。焦虑敏感性（AS）是大学期间抑郁症状的主要预测因素，但其具体机制仍不清楚。本研究采用链式中介模型对这一关系进行了研究。方法通过便利抽样法选取了居住在中国东北部辽宁省的 1261 名符合条件的学生（平均年龄为 20.20±1.37 岁）进行了全面调查。研究中使用的自我报告问卷包含一系列参数，包括一般信息问卷、焦虑敏感指数-3（ASI-3）、复原力量表-14（RS-14）、抑郁、焦虑和压力量表（DASS-21）。使用 R 4.3.2 统计软件对调查数据进行了皮尔逊相关分析、结构方程模型检验和 Bootstrap 偏差校正百分位数分析。复原力与 AS、压力和抑郁症状呈负相关。除了自闭症对抑郁症状的直接影响外，压力和复原力在自闭症的生理和认知关注与抑郁症状之间的关系中也起到了部分中介作用，总的间接效应分别占91.5%和92.1%，并完全中介了自闭症的社会关注与抑郁症状之间的关系。结论该研究结果表明，可以采取实际行动来减少自闭症和压力，从而增强青少年的复原力，减少抑郁症状。

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引用次数: 0

Assessing the relationship between lifestyle factors and mental health outcomes among Afghan university students 评估生活方式因素与阿富汗大学生心理健康结果之间的关系

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100827

Ali Rahimi , Mohammad Faisal Wardak , Nasar Ahmad Shayan

Background

Lifestyle factors such as physical activity, diet, and sleep can impact university students' mental health. This study examined the associations between lifestyle and mental health among students at Herat University in Afghanistan.

Methods

A cross-sectional study was conducted among 677 students selected through stratified random sampling. Participants completed a questionnaire on socio-demographics, physical health, dietary habits, and the Depression Anxiety Stress Scale (DASS-42). Chi-square tests and logistic regression analyzed the relationships between lifestyle factors and DASS-42 scores.

Results

Poor perceived health and irregular breakfast consumption were associated with higher odds of depression and anxiety. Low vegetable intake also increases the odds of depression and anxiety. Studying non-medical fields and irregular sleep patterns were linked to higher stress levels.

Conclusion

Comprehensive health promotion and targeted interventions addressing dietary habits, sleep, and discipline-specific needs may improve the mental well-being of university students. A multidimensional approach is required to foster a healthy campus environment.

背景体育锻炼、饮食和睡眠等生活方式因素会影响大学生的心理健康。本研究调查了阿富汗赫拉特大学学生的生活方式与心理健康之间的关系。方法通过分层随机抽样的方式，对 677 名学生进行了横断面研究。参与者填写了一份关于社会人口统计学、身体健康、饮食习惯和抑郁焦虑压力量表（DASS-42）的问卷。通过卡方检验和逻辑回归分析了生活方式因素与 DASS-42 评分之间的关系。蔬菜摄入量低也会增加抑郁和焦虑的几率。结论针对饮食习惯、睡眠和特定学科需求的全面健康促进和有针对性的干预措施可改善大学生的心理健康。要营造健康的校园环境，需要采取多维度的方法。

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引用次数: 0

Self-poisoning evaluated in the emergency department of a general hospital in the years 2014–2020 and the provision of psychiatric services before and after the index event 2014-2020年一家综合医院急诊科对自我中毒事件的评估以及在事件发生前后提供的精神科服务

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100835

Cesare Turrina , Lorenzo Silva , Daria Bettoni , Ciro Paolillo , Tullio Elia Testa , Antonio Vita

Background

The recent literature on self-poisoning (SP) has mainly focused on the type of substances used for SP and the associated variables. Few data are available on psychiatric diagnoses, repeated SP, multiple substances SP, contacts with psychiatric services before the event and after a long follow-up.

Methods

A consecutive series of 1.807 subjects evaluated in the emergency department of a large urban university hospital was collected from 2014 to 2020. These subjects were matched with the data of Psyche-Web, a case register collecting all psychiatric contacts of the Lombardia Region, Italy.

Results

The most used drugs were benzodiazepines (37.8 %), cocaine (24.0 %), cannabis (15.2 %), antipsychotics (10.5 %), antidepressants (9.2 %). Alcohol was associated in 27.0 % of the cases. The most frequent psychiatric diagnoses were substance use (28.8 %), personality disorders (24.5 %), and mood disorders (21.7 %). Subjects who repeatedly self-poisoned were younger, more often suffered from a personality disorder and less often from a substance use disorder. In 38.2 % of the sample SP was the first-time presentation to psychiatric evaluation of a mood, personality, or psychotic disorder. At one-year follow-up 63.3 % were not in contact with psychiatric services.

Limitations

This study could not include children and adolescents because Psyche-Web stores data only for the adult population. Psychiatric diagnoses were given by specialists, but in different settings.

Conclusions

A substantial number of subjects with no previous contacts remained out of the reach of psychiatric care after discharge. A subgroup of these patients would probably benefit of a more structured referral.

背景最近有关自毒（SP）的文献主要集中在自毒所用物质的类型和相关变量上。方法收集了2014年至2020年期间在一家大型城市大学医院急诊科接受评估的1 807名连续序列受试者的数据。结果使用最多的药物是苯二氮卓（37.8%）、可卡因（24.0%）、大麻（15.2%）、抗精神病药（10.5%）和抗抑郁药（9.2%）。27.0%的病例与酒精有关。最常见的精神病诊断是药物使用（28.8%）、人格障碍（24.5%）和情绪障碍（21.7%）。屡次自我中毒的受试者年龄较轻，更多患有人格障碍，而较少患有药物使用障碍。在 38.2% 的样本中，SP 是因情绪、人格或精神障碍而首次接受精神评估。在一年的随访中，63.3%的人没有接触过精神科服务。局限性由于 Psyche-Web 仅存储了成年人的数据，因此本研究无法将儿童和青少年包括在内。结论大量以前没有接触过精神病治疗的患者在出院后仍然得不到精神病治疗。这些患者中的一部分可能会从更有组织的转诊中受益。

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引用次数: 0

Psychometric examination and factorial validity of a German short form of the Beck Hopelessness Scale in three different samples 贝克无望感量表德文简表在三个不同样本中的心理测量学检验和因子效度

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100822

T. Forkmann , J. Eimen , L. Plein , I. Höller , L. Böhler , A. Schönfelder , N. Hallensleben , D. Schreiber , L. Paashaus , G. Juckel , T. Teismann , H. Glaesmer , L. Spangenberg

Background

Hopelessness is a transdiagnostically relevant clinical construct, related to depression, post-traumatic stress disorder and suicidality. Economic, valid, and reliable assessment of hopelessness is thus crucial for both research and clinical practice. This study aimed at validating a nine-item short version of the Beck Hopelessness Scale in three large German samples of psychiatric inpatients, psychotherapy outpatients, and healthy controls.

Methods

Data from N = 2321 participants (86.3 % female, mean age 31.8 years [SD=10.4]) were used to analyze reliability, factorial validity, concurrent and discriminant validity of the BHS-9.

Results

Results showed good psychometric characteristics of the BHS-9 in inpatients, supporting its unidimensionality, construct validity, and reliability. However, factorial validity was insufficient in outpatients and controls.

Limitations

In the outpatient and control samples, the majority of participants were women. All reported analyses were cross-sectional.

Conclusions

The BHS-9 appears to be suitable for assessing hopelessness in psychiatric inpatients. However, the factorial validity of this short instrument in non-inpatient settings should be subject to future studies before its implementation in these person groups can be recommended.

背景无望感是一种与抑郁症、创伤后应激障碍和自杀有关的跨诊断相关临床结构。因此，对无望感进行经济、有效和可靠的评估对研究和临床实践都至关重要。本研究的目的是在德国三个大型精神病住院患者、心理治疗门诊患者和健康对照者样本中验证 Beck 无望感量表的九个条目简版。结果结果显示，BHS-9 在住院患者中具有良好的心理测量特征，支持其单维性、建构有效性和可靠性。局限性在门诊病人和对照组样本中，大多数参与者为女性。结论BHS-9似乎适用于评估精神病住院患者的绝望感。然而，在非住院环境中使用这一简短工具的因子有效性还需要未来的研究来验证，然后才能建议在这些人群中使用。

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引用次数: 0

Prevalence and risk factors for anxiety, stress and depression among higher education students in Portugal and Brazil 葡萄牙和巴西高校学生中焦虑、压力和抑郁的流行率和风险因素

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100825

Carmona Laura , Costa Carlos , Gascón Santiago , Ribeiro Graziela , Chambel Maria José

Objective

Determine the prevalence and risk factors for anxiety, stress and depression among higher education students in a sample from Portugal and Brazil.

Methods

Students from Portugal (n = 709) and Brazil (n = 487) answered the Depression, Anxiety and Stress Scale (DASS-21) and demographic and academic characteristics questions.

Results

Rates of anxiety, stress, and depression were 55.3 %, 55.9 % and 56.3 % for Portuguese students and 71.5 %, 75.6 % and 68.2 % for Brazilian students, respectively. In the total sample, being Brazilian was found to predict anxiety, stress and depression. In both samples, being female was found to predict anxiety and stress. Being displaced was also found to affect mental health: anxiety for the Portuguese sample; stress for the Brazilian sample. Furthermore, in the Portuguese sample, fields of study were found to affect mental health: Education and Human Motricity protected from anxiety, stress and depression; Psychology protected from anxiety and depression; Medicine protected from depression. Non-working status was also found to predict depression in this sample.

Limitations

The cross-sectional design prevents the establishment of causal relationships; self-report measures may be susceptible to response bias; the recruitment of participants may be susceptible to selection bias; cultural factors and institutional differences between these countries may affect mental health.

Conclusions

Country, gender, displacement, field of study, and working status were found to affect higher education students’ mental health. From a clinical perspective, specific programs addressing anxiety, stress and depression in university students should be tested, as these disorders have a noteworthy prevalence in this population.

方法葡萄牙（709 人）和巴西（487 人）的学生回答了抑郁、焦虑和压力量表 (DASS-21) 以及人口统计学和学术特征问题。在所有样本中，发现巴西籍学生可预测焦虑、压力和抑郁。在这两个样本中，都发现女性身份可预测焦虑和压力。流离失所也会影响心理健康：葡萄牙样本会产生焦虑；巴西样本会产生压力。此外，在葡萄牙样本中，研究领域也会影响心理健康：教育和人类动力免受焦虑、压力和抑郁的影响；心理学免受焦虑和抑郁的影响；医学免受抑郁的影响。局限性横断面设计妨碍了因果关系的建立；自我报告措施可能容易出现反应偏差；参与者的招募可能容易出现选择偏差；这些国家之间的文化因素和制度差异可能会影响心理健康。从临床角度来看，应测试针对大学生焦虑、压力和抑郁的具体方案，因为这些疾病在这一人群中的发病率很高。

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引用次数: 0

Moral distress as a persistent risk factor for impaired mental health among healthcare workforce 精神痛苦是医护人员心理健康受损的一个持久性风险因素

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100817

Alice Fattori , Anna Comotti , Paolo Brambilla , Matteo Bonzini

Background

Moral distress among healthcare workers (HCWs) has dramatically increased during Covid-19 emergency however most evidence relies on cross-sectional data collected during Covid-19 early stages.

Aims

This longitudinal cohort study aims to provide a better insight into the occurrence and associations of moral distress, focusing on both its short and long-term impact on HCWs’ mental health.

Methods

A total of 990 healthcare workers completed a mental health evaluation between July 2020-July 2021 (Time 1) reporting frequencies of moral distress and psychological distress (GHQ-12), post-traumatic (IES-R) and anxiety (GAD-7) symptoms; after one year (July 2021-July 2022; Time 2), 310 participants repeated the psychological evaluation. We investigated differences considering socio-demographic and occupational characteristics. Two logistic regression models examined the potential role of moral distress as a risk factor for scorings above scales’ cut-offs at Time 1 and at Time 2.

Results

Frequent episodes of moral distress were mostly reported by nurses (24 %), physicians (22 %), younger workers (<40y; 23 %) and workers engaged in Covid-19 area; HCWs from Emergency/Intensive Care Departments reported the highest occurrence of moral distress (29 %). Results showed increases in all psychological symptoms as episodes of moral distress became more frequent. Moral distress experienced at Time 1 resulted as a persistent risk for mental health impairment in the following year, with stable ORs for post-traumatic symptoms (Time1 OR=7.8, 95 %CI=(5.3,11.6) and Time2 OR=6.6, 95 %CI=(2.9,15.7).

Conclusions

Our findings support long-term consequences of moral distress; preventive strategies may be addressed with priority to younger HCWs and nurses/physicians from Emergency and Intensive Care Departments.

背景在 Covid-19 紧急事件期间，医护人员（HCWs）的道德困扰急剧增加，但大多数证据都依赖于在 Covid-19 早期阶段收集的横断面数据。目的这项纵向队列研究旨在更好地了解道德困扰的发生和关联，重点关注其对医护人员心理健康的短期和长期影响。方法共有990名医护人员在2020年7月至2021年7月（时间1）期间完成了心理健康评估，报告了道德困扰和心理困扰（GHQ-12）、创伤后（IES-R）和焦虑（GAD-7）症状的频率；一年后（2021年7月至2022年7月；时间2），310名参与者重复了心理评估。我们调查了社会人口特征和职业特征的差异。结果护士（24%）、医生（22%）、年轻工人（<40y; 23%）和从事 Covid-19 领域工作的工人报告的精神压力发作频率最高（29%）。结果显示，随着道德困扰发生的频率增加，所有心理症状也随之增加。结论：我们的研究结果支持道德困扰的长期后果；预防策略可优先考虑年轻的医护人员以及急诊科和重症监护室的护士/医生。

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引用次数: 0

The continuum of recovery among Canadians with bipolar disorder: From remission to complete mental health 加拿大躁郁症患者康复的连续性：从病情缓解到完全心理健康

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100808

Objectives

Research on recovery from bipolar disorder focuses primarily on symptom remission and diagnostic criteria. Less attention, however, has been paid to other aspects of mental well-being and psychosocial functioning. The current study examines the prevalence of, and factors associated with, recovery from bipolar disorder through three levels: (1) remission from bipolar disorder; (2) the absence of psychiatric disorders (APD); and (3) complete mental health (CMH), which incorporates measures of happiness, life satisfaction, psychological flourishing, and absence of mental illness.

Methods

Data were drawn from the 2012 Canadian Community Health Survey-Mental Health. A subsample of 555 adults with bipolar disorder was analyzed using bivariate chi-square analyses and multivariate logistic regression models.

Results

Approximately 1 in 4 (23 %) participants with bipolar disorder achieved CMH, which was significantly lower than the 74 % of those without bipolar disorder who were in CMH. Factors associated with CMH among individuals with bipolar disorder included older age, higher household income, being married, having a confidant, utilizing religion or spirituality for coping, and being free from substance abuse or dependence and debilitating chronic pain.

Limitations

Absence of data on certain mental disorders, exclusion of hospitalized or unresponsive participants, and social desirability, may have biased the results.

Conclusion

By identifying factors associated with CMH among those with bipolar disorder, this study provides insight into recovery from bipolar disorder beyond symptom remission, highlights subpopulations who may be at heightened risk of further adverse mental health outcomes, and helps inform interventions that support recovery for individuals affected by bipolar disorder.

研究目的有关躁郁症康复的研究主要集中在症状缓解和诊断标准方面。然而，人们较少关注精神健康和心理社会功能的其他方面。本研究从三个层面研究了双相情感障碍康复的患病率和相关因素：（1）双相情感障碍缓解；（2）无精神障碍（APD）；（3）完全心理健康（CMH），其中包括幸福感、生活满意度、心理健康和无精神疾病等指标。结果大约四分之一（23%）的双相情感障碍参与者达到了CMH，明显低于74%的无双相情感障碍者达到CMH。双相情感障碍患者中与CMH相关的因素包括年龄较大、家庭收入较高、已婚、有知己、利用宗教或灵性来应对、无药物滥用或依赖以及无使人衰弱的慢性疼痛。局限性缺乏某些精神障碍的数据、排除住院或无反应的参与者以及社会期望性可能会使结果产生偏差。结论通过确定与双相情感障碍患者CMH相关的因素，本研究深入探讨了双相情感障碍患者在症状缓解后的康复情况，强调了可能面临更多不良心理健康后果风险的亚人群，并有助于为支持双相情感障碍患者康复的干预措施提供信息。

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引用次数: 0

Evaluating the effectiveness of transcranial direct current stimulation on improving cognitive function in bipolar patients 评估经颅直流电刺激对改善双相情感障碍患者认知功能的效果

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2024-07-01 DOI: 10.1016/j.jadr.2024.100818

Ali Talaei , Ali Akbari , Mahdiyeh Sarraf-Razavi , Shabnam Niroumand , Dina Ganji , Maryam Aghasizadeh , Ali Azadmand , Maryam Tayyebi-Meybodi , Sanam Tayyebi-Meybodi

Background

Bipolar disorder is classified as one of the most debilitating mental diseases. Although patients receive medical treatment, cognitive deficits remain in the euthymic phase in many patients. It is hypothesized that brain electrical stimulation protocols that increase cognitive function may increase the quality of life. Therefore, this study aimed to evaluate the effectiveness of transcranial direct current stimulation in improving cognitive function in bipolar patients in the euthymic phase.

Methods & Materials

In a double-blind, sham-controlled- clinical trial, 46 euthymic bipolar patients diagnosed based on DSM-V were randomly divided into the two intervention and control groups. tDCS was applied for the intervention group using an anode electrode at the left dorsolateral-peripheral cortex (F3) and the cathode at the right dorsolateral-frontal (F4) (based on the 10/20 system) at 2 mA for 20 min. The Strop Color and Word Test, The Rey Auditory Verbal Learning Test (RAVLT), and The Wechsler Adult Intelligence Scale (WAISR) were evaluated before, at the end of the third and the seventh weeks of the intervention. Statistical analysis was performed using SPSS v 16.

Results

The scores of immediate and delayed auditory memory and visual memory in the intervention group, unlike the control group, improved significantly after treatment. Moreover, Wechsler's working memory score in the intervention group improved significantly after treatment. Consistent and inconsistent answers scores were also significantly improved in the intervention group compared with the controls.

Conclusion

The present study indicated that tDCS might be an efficient and safe method for improving cognitive function in euthymic bipolar patients.

背景躁郁症被列为最令人衰弱的精神疾病之一。尽管患者接受了药物治疗，但许多患者在缓解期仍存在认知障碍。据推测，能提高认知功能的脑电刺激方案可提高患者的生活质量。因此，本研究旨在评估经颅直流电刺激在改善躁狂症痊愈期患者认知功能方面的效果。方法与amp; 材料在一项双盲、假对照临床试验中，46名根据DSM-V诊断的躁狂症痊愈期患者被随机分为干预组和对照组。干预组在左侧背外侧-外周皮层（F3）处使用阳极电极，在右侧背外侧-额叶（F4）处使用阴极电极（基于 10/20 系统），电流为 2 mA，持续 20 分钟。在干预前、干预第三周和第七周结束时，分别对 Strop 颜色和单词测试、雷伊听觉言语学习测试（RAVLT）和韦氏成人智力量表（WAISR）进行了评估。结果与对照组不同的是，干预组的即时和延迟听觉记忆及视觉记忆得分在治疗后有显著提高。此外，干预组的韦氏工作记忆得分在治疗后也有明显改善。结论本研究表明，tDCS 可能是一种有效且安全的改善躁狂症患者认知功能的方法。

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引用次数: 0