Journal of Affective Disorders Reports最新文献

{"title":"The impact of expectations on treatment outcomes following intensive psychotherapy in inpatients with major depression","authors":"Reinhard Maß ,&nbsp;Kerstin Backhaus ,&nbsp;Bodo Karsten Unkelbach","doi":"10.1016/j.jadr.2025.100997","DOIUrl":"10.1016/j.jadr.2025.100997","url":null,"abstract":"<div><div>Patients’ expectations concerning the effectiveness of treatment play a significant role in shaping clinical outcomes. These expectations are, in part, influenced by the explanatory models patients hold regarding the etiology of their illness. In the case of depression, both psychotherapeutic and pharmacological treatment options are available, each associated with distinct etiological models—psychological and biomedical, respectively.</div><div>Our study aimed to examine the significance of pre-treatment expectations regarding the helpfulness of medication or psychotherapy for treatment outcomes in depression.</div><div>A total of 635 inpatients diagnosed with major depressive disorder were included. Upon admission, all patients were asked to rate two statements assessing their expectations regarding the potential benefits of medication and psychotherapy. Depressive symptom severity was evaluated using the revised Beck Depression Inventory (BDI-II). Additionally, a subsample of 290 patients was queried about their beliefs concerning the etiology of their depression, including ongoing stress, metabolic imbalances in the brain, adverse childhood experiences, and genetic predisposition.</div><div>Mean BDI-II scores decreased substantially from admission to discharge. Expectations of receiving help through medication were more strongly associated with biomedical explanatory models, whereas expectations of benefiting from psychotherapy were more closely linked to psychological explanations. Regression analysis revealed that the reduction in depressive symptoms was attenuated by high expectations of benefit from medication, while optimistic expectations regarding psychotherapy were associated with greater symptom improvement.</div><div>Our findings suggest that fostering patients’ confidence in psychotherapy is important. Moreover, biomedical explanations for depression should not be promoted, particularly given the limited scientific evidence supporting them.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 100997"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning prediction of psychological resilience: An analysis of health and self-perception variables","authors":"Javier Díaz Esteban-Herreros ,&nbsp;Miriam Garrido-Miguel ,&nbsp;Vicente Martínez-Vizcaíno ,&nbsp;Ana Isabel Torres-Costoso ,&nbsp;Asunción Ferri-Morales ,&nbsp;Juan Moreno-Garcia ,&nbsp;Elizabeth Bravo Esteban-Herreros","doi":"10.1016/j.jadr.2025.101000","DOIUrl":"10.1016/j.jadr.2025.101000","url":null,"abstract":"<div><div>This study aims to evaluate the associations between psychological resilience and various health-related factors, including diet, smoking, alcohol use, and physical self-perception, in a sample of university students. The primary objective is to identify factors that are most significantly related to resilience and to determine their ability to predict an individual’s resilience level. A total of 360 university students participated in this cross-sectional study. Data were collected via validated questionnaires, such as the CD-RISC (Connor and Davidson, 2003) for psychological resilience, the PREDIMED (Guasch-Ferré et al., 2017) for the Mediterranean diet, the AUDIT (Kuitunen-Paul and Roerecke, 2018) for alcohol consumption risk, and the SCOFF (Morgan et al., 1999) for disordered eating behaviors. Additionally, questionnaires designed by researchers were used to assess smoking status and body image. Advanced machine learning models, specifically Random Forest (Breiman, 2001) (<span><span>Breiman, 2001</span></span>) and TabNet (Arik and Pfister, 2021) were applied to predict the resilience levels. To address class imbalance, the SMOTE technique was used. The model performance was measured via the macro F1-score, a metric suitable for imbalanced datasets. Additionally, the importance values of the predictor variables were calculated to provide interpretability. A clustering analysis was also conducted to segment the population on the basis of their characteristics. Our predictive models achieved moderate accuracy but successfully identified the most influential variables for resilience. Perceived health and body image emerged as key predictors of psychological resilience. A positive association was also found between adherence to a healthy diet and increased resilience. Clustering analysis revealed two distinct resilience groups, with the lower resilience group showing a greater risk of alcohol dependence. Finally, our findings confirm the associations between psychological resilience and various health habits and self-perceptions. The study provides a novel applications of machine learning to a psychological construct, identifying key predictors and demonstrating the complexity of these relationships. While this research provides valuable insights, future studies should consider larger sample sizes and a longitudinal design to further explore these dynamics and incorporate a broader range of sociocultural and familial factors.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 101000"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validated self-administered screening tools to identify depression among young adults (18 to 25-years-old) in East Asia and the Pacific Region low-and-middle income countries (LMICs): A systematic review","authors":"Dennis Emralino Dantic ,&nbsp;Rebecca Sudhir Jaya ,&nbsp;Rafael Gafoor ,&nbsp;Louise Marston","doi":"10.1016/j.jadr.2025.100999","DOIUrl":"10.1016/j.jadr.2025.100999","url":null,"abstract":"<div><div>This systematic review evaluates the validity, reliability, and diagnostic accuracy of self-administered screening tools for symptoms of depression among young adults (18 to 25 years old) in East Asia and the Pacific. A total of 22 studies with 24,069 participants were included, covering both clinical and non-clinical populations. Nine self-administered screening tools were identified, with Patient Health Questionnaire-9 (PHQ-9), Patient Health Questionnaire-2 PHQ-2, and Centre for Epidemiological Studies Depression (CES-D) being the most frequently studied. PHQ-9 demonstrated moderate to excellent internal consistency reliability, with Cronbach’s alpha ranging from 0.67 to 0.92, and a pooled AUC of 0.86, indicating strong screening accuracy. PHQ-2, showed an Area Under the Curve (AUC) of 0.85, high sensitivity (0.96), and moderate specificity (0.80). CES-D exhibited an AUC of 0.87, good sensitivity (0.81), and specificity (0.78), with high heterogeneity (I² = 74.70 %–86.69 %). The meta-analysis revealed substantial variability in sensitivity and specificity across settings, with differences in study methodologies, cutoff scores, and reference standards contributing to high heterogeneity. Additionally, 95.5 % of studies had a moderate risk of bias in patient selection, affecting generalizability. Despite these limitations, PHQ-9, PHQ-2, and CES-D remain valuable tools for identifying symptoms of depression among young adults. The accessibility, ease of administration, and strong psychometric properties of these tests support their continued use in resource-limited settings, though standardization of methodologies and expanded regional validation are needed to improve screening accuracy and applicability.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 100999"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the psychometric properties of patient-reported outcome measures for adolescent depression: A COSMIN systematic review","authors":"Christopher J. Rikard-Bell ,&nbsp;Justin Botros ,&nbsp;Caroline Hunt ,&nbsp;Philippa Hay ,&nbsp;Michelle Cunich ,&nbsp;Stephen Touyz","doi":"10.1016/j.jadr.2025.100993","DOIUrl":"10.1016/j.jadr.2025.100993","url":null,"abstract":"<div><h3>Objectives</h3><div>This review evaluated the quality and suitability of current Patient-Reported Outcome Measures for measuring depressive symptoms and diagnosing depression in adolescents, including whether there is any measurement of potential developmental aetiological factors.</div></div><div><h3>Methods</h3><div>On August 8, 2024, the databases Web of Science, PsycINFO, Scopus, and Ovid Medline were searched for studies on psychometric instruments designed to detect adolescent depressive symptoms. Two reviewers searched for relevant articles, extracted data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and assessed the quality of studies and instruments using the 2018 and 2024 Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines for the systematic review of Patient-Reported Outcome Measures. Additional evaluation of instrument content assessed whether items addressed developmental aetiology. PROSPERO CRD42020175950.</div></div><div><h3>Results</h3><div>57 publications met the inclusion criteria, identifying 16 instruments for quality assessment. Most instruments for measuring adolescent depressive symptoms were adaptations of adult depression scales based on adult diagnostic criteria. According to COSMIN criteria, three instruments - the BDI-2, MFQ, and PHQ - received an A rating, 12 a B rating, and one a C rating, based on the quality of evidence for their measurement properties. None of the instruments directly assessed developmental aetiological factors.</div></div><div><h3>Conclusion</h3><div>While some high-quality psychometric instruments are available for identifying adolescent depressive symptoms, further development of psychometric instruments is needed to incorporate potential aetiological factors relevant to adolescent development in the context of depressive symptoms.</div></div><div><h3>Systematic review registration</h3><div>CRD42020175950.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 100993"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent suicidality: A systematic scoping review of the literature","authors":"Mette M. Palm ,&nbsp;Elke Elzinga ,&nbsp;Leah Middelkoop ,&nbsp;Almar A.L. Kok ,&nbsp;Kairi Kõlves ,&nbsp;Aartjan T.F. Beekman ,&nbsp;Sisco M.P. van Veen","doi":"10.1016/j.jadr.2025.100996","DOIUrl":"10.1016/j.jadr.2025.100996","url":null,"abstract":"<div><h3>Background</h3><div>Suicidality can extend beyond the acute phase and be a long-term condition. Known by various terms, including chronic or persistent suicidality (PS), this phenomenon is well recognized in clinical practice. However, a comprehensive synthesis and evaluation of the literature is missing, leaving the scope and focus of the current scientific evidence on PS unclear.</div></div><div><h3>Aims</h3><div>This review aims to identify and critically appraise the literature on PS. It seeks to provide an overview of how the evidence defines and operationalises PS, its occurrence, and the characteristics of individuals affected by it.</div></div><div><h3>Method</h3><div>A systematic scoping review was conducted following the PRISMA-ScR guidelines. After preregistration, searches were conducted in six databases: Embase, PubMed, APA PsycInfo, Web of Science, Scopus, and ERIC. Articles describing individuals with suicidal ideation or a death wish lasting a year or longer were included. Quality appraisal was performed using the National Institute of Health's quality assessment tools. Due to the pluriformity of the literature a narrative synthesis was conducted.</div></div><div><h3>Results</h3><div>In total, 63 articles met the criteria for inclusion. Around one-third of individuals experience suicidal ideation that persist over the long term. There is a strong overall association between PS and psychiatric or psychological distress. Results suggest that specific variables may help differentiate between individuals with transient suicidal ideation and those at risk for PS.</div></div><div><h3>Conclusions</h3><div>Despite sufficient quality of most studies reporting PS, the field is hindered by inconsistent operationalisations and a lack of study replication. This study highlights the need for a uniform understanding of PS and proposes a provisional definition.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 100996"},"PeriodicalIF":0.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential esketamine and dextromethorphan-bupropion in treatment-resistant depression with bipolar features: A case report","authors":"Neekoo Farahmandpour ,&nbsp;Fatma Wafy ,&nbsp;Jeffrey Feola","doi":"10.1016/j.jadr.2025.100994","DOIUrl":"10.1016/j.jadr.2025.100994","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD) remains a major clinical challenge, particularly in patients with bipolar spectrum features where standard antidepressants often fail. Novel glutamatergic and sigma-1 receptor–modulating agents such as intranasal esketamine and dextromethorphan-bupropion (Auvelity) offer promising alternatives. We report the case of a 43-year-old male with recurrent depression and bipolar II features who had failed eight antidepressant and mood-stabilizing trials over two decades. A four-week course of intranasal esketamine at Kings County Hospital Center produced marked improvement, with remission lasting approximately six months. After relapse, treatment with dextromethorphan-bupropion led to renewed and sustained recovery without mania or hypomania. This sequential response suggests esketamine may serve as an induction treatment, with dextromethorphan-bupropion providing a feasible maintenance option in TRD with bipolar features. The case highlights the importance of recognizing bipolarity in treatment-resistant presentations and demonstrates the potential of sequential glutamatergic and sigma-1 receptor–modulating therapies when long-term esketamine is impractical. Controlled studies are warranted to identify predictors of response, long-term safety, and optimal treatment sequencing.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 100994"},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding risky sexual behaviors assessment and factors among men engaging in sexual activities with other men (MSM) in Palembang city","authors":"Rico Januar Sitorus ,&nbsp;Debby Amanda Putri ,&nbsp;Anita Rahmiwati ,&nbsp;Rizma Adlia Syakurah ,&nbsp;Merry Natalia Panjaitan ,&nbsp;Akhmad Dwi Priyatno ,&nbsp;Nyoman Yudi Antara","doi":"10.1016/j.jadr.2025.100992","DOIUrl":"10.1016/j.jadr.2025.100992","url":null,"abstract":"<div><h3>Background</h3><div>Men who have sex with men (MSM) are often perceived as exclusively homosexual, although some identify as bisexual. Social and familial pressures may influence sexual behavior, contributing to engagement in high-risk sexual behaviors and increasing HIV transmission risk. This study aimed to describe risky sexual behaviors among MSM and identify associated psychosocial and demographic factors.</div></div><div><h3>Methods</h3><div>A cross-sectional quantitative study was conducted in Palembang. Purposive sampling recruited 240 MSM participants. Risky sexual behaviors were assessed using a validated instrument adapted from previous studies. Logistic regression was used to identify factors associated with high-risk behaviors.</div></div><div><h3>Results</h3><div>Of the participants, 76.5 % engaged in high-risk sexual behaviors. A majority of respondents who reported homosexual orientation also disclosed having experienced childhood sexual abuse; this experience was often mentioned as a meaningful life event shaping their self-perception.Self-efficacy was the strongest predictor of risky sexual behaviors: MSM with low self-efficacy had a 4.022 fold higher likelihood of engaging in high-risk behaviors compared to those with high self-efficacy (adjusted OR = 4.022, 95 % CI: (2.408–7.899)</div></div><div><h3>Limitations</h3><div>The study may be subject to information bias, as respondents’ initial discomfort and fear could have affected the accuracy of self-reported sexual behaviors. The use of purposive sampling may also limit the generalizability of the findings.</div></div><div><h3>Conclusions</h3><div>Risky sexual behaviors among MSM are significantly associated with sexual orientation and self-efficacy. Societal and familial pressures may compel homosexual-identified individuals to engage in heterosexual relationships. Interventions addressing psychosocial determinants and risk-reduction strategies are needed to mitigate HIV risk in this population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"22 ","pages":"Article 100992"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term consequences on mental health and health related quality of life among COVID-19 patients with different disease severities","authors":"Marlise P. de Roos ,&nbsp;Marië A.C. Nijpels ,&nbsp;Nynke G. Dijkstra ,&nbsp;Sebastiaan Siegerink ,&nbsp;Laura N. Samwel ,&nbsp;Felix K.A. Pettai ,&nbsp;Sander C. Albers ,&nbsp;Nini H. Jonkman ,&nbsp;Kees Brinkman ,&nbsp;Paul Bresser ,&nbsp;Birit F.P. Broekman","doi":"10.1016/j.jadr.2025.100988","DOIUrl":"10.1016/j.jadr.2025.100988","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic has been associated with an increase in mental health problems and a decline in health-related quality of life (HRQoL). It has been hypothesized that disease severity of COVID-19 pneumonia may increase the risk for long-term anxiety, depressive and posttraumatic stress symptoms. This exploratory study investigates the relationship between the severity of COVID-19 infection in admitted and non-admitted patients and the prevalence of anxiety, depressive and post-traumatic stress symptoms as well as quality of life up to 2 years post COVID-19.</div></div><div><h3>Method</h3><div>COVID-19 survivors were categorized in three subgroups: “moderate” (no need for hospitalization), “severe” (hospitalization requiring oxygen), and “critical” cases (respiratory failure and intensive care unit admission). Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI) and HRQoL (Short Form SF-36 health survey) were studied at 3, 6, 12 and 24 months follow-up visits. Data were analysed using (repeated measures) linear mixed-effects models.</div></div><div><h3>Results</h3><div>A high burden of disease persists two years after COVID, manifested by mental health symptoms and reduced quality of life across all subgroups. No significant differences were observed in the development of mental health symptoms over time between the three subgroups, except less posttraumatic stress symptoms in critically ill COVID patients compared to severe or moderate COVID patients after 2 years.</div></div><div><h3>Conclusions</h3><div>Up to 2 years after COVID-19 pneumonia, mental health symptoms and decreased quality of life are prevalent, but this is not related to the severity of COVID-19 pneumonia.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"23 ","pages":"Article 100988"},"PeriodicalIF":0.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Profile of suicides in a spanish cohort of people living with HIV (PLWH)’ [Journal of Affective Disorders Reports 22 (2025)100980]","authors":"Julián Olalla ,&nbsp;Joaquim Peraire ,&nbsp;Roberto Carlos Güerri Fernández ,&nbsp;Naya Faro ,&nbsp;Antonia Maria Castillo-Navarro ,&nbsp;Pepa Galindo ,&nbsp;Nuria Espinosa ,&nbsp;Javier Pérez-Stachowski ,&nbsp;Alfonso del Arco ,&nbsp;Javier de la Torre ,&nbsp;Francisco Rivas ,&nbsp;on behalf CoRIS Cohort*","doi":"10.1016/j.jadr.2025.100987","DOIUrl":"10.1016/j.jadr.2025.100987","url":null,"abstract":"","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"22 ","pages":"Article 100987"},"PeriodicalIF":0.0,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation/inhibition in major depressive episodes of unipolar, bipolar, and borderline patients measured with the multidimensional assessment of Thymic States (MAThyS)","authors":"J. Lumikukka Socada ,&nbsp;John J. Söderholm ,&nbsp;Tom Rosenström ,&nbsp;Jari Lahti ,&nbsp;Jesper Ekelund ,&nbsp;Erkki T. Isometsä","doi":"10.1016/j.jadr.2025.100991","DOIUrl":"10.1016/j.jadr.2025.100991","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive episodes (MDEs) are phenomenologically heterogeneous. The Multidimensional Assessment of Thymic States (MAThyS) scale was developed to estimate activation/inhibition, emotional reactivity, and to differentiate types of depression in bipolar disorder (BD). Their role in diagnosis or other depressions remains unclear.</div></div><div><h3>Methods</h3><div>We assessed validity of Finnish translation of the MAThyS in 94 patients with Major Depressive Disorder (MDD), MDE/BD, or MDE/BPD (MDE comorbid with Borderline Personality Disorder), and 29 healthy controls. We examined the associations of MAThyS total score with depression severity (MADRS), (hypo)manic symptoms (YMRS, MIXMDE), and BPD severity (BPDSI), assessed internal consistency, and conducted confirmatory factor analysis to test the postulated two-factor structure.</div></div><div><h3>Results</h3><div>MAThyS demonstrated good internal consistency in patient subcohorts (Cronbach’s α = 0.78–0.88), but not in controls (α = 0.19). In hierarchical regression model (adjusted R² = 0.34), MAThyS total score was negatively associated with depression severity (MADRS) (β = –0.316, p = 0.003), but positively with mixed symptoms (MIXMDE; β = 0.319, p = 0.017), borderline severity (BPDSI; β = 0.195, p = 0.13) and momentary (hypo)manic symptoms (YMRS; β = 0.171, p = 0.15). The two-factor model had poor fit (CFI = 0.687; RMSEA = 0.125).</div></div><div><h3>Conclusions</h3><div>The Finnish MAThyS translation retains good internal consistency, for total scores assessed in MDE patient subgroups, but validity of the scale in assessing activation and emotional reactivity specifically remains unclear. MAThyS may aid in detecting signs of increased activation and mixed features. Further studies are needed to evaluate its validity and clinical utility.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"22 ","pages":"Article 100991"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}