Journal of Affective Disorders Reports最新文献_第2页

Understanding the natural landscape of the chronology of major depressive disorder and mania in youth 了解青少年重度抑郁障碍和躁狂症年表的自然景观

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jadr.2026.101037

Maria Iorini , Maura DiSalvo , Gagan Joshi , Janet Wozniak , Mai Uchida

Introduction

Major Depressive Disorder (MDD) and Bipolar Disorder (BPD) are debilitating disorders increasingly prevalent in pediatric populations. MDD and BPD often share depressive symptoms, making them difficult to distinguish. Despite these similarities, treatment courses differ vastly, and incorrect prescriptions can worsen the clinical course. Thus, accurate diagnosis is critical. Further complicating diagnosis is that BPD may initially present with depression, mania, or both. However, there is limited literature examining the course of disorder development. This was a naturalistic cohort study aiming to identify the main patterns of symptoms and relationship to MDD versus BPD development over time.

Methods

A cross-sectional assessment of psychiatric interviews (K-SADS-E) was reviewed from 2947 consecutive referrals of patients aged 3 to 17 to a pediatric psychopharmacology program (1991–2008).

Results

46% (n = 1357) of the sample met criteria for depression and/or mania. Among them, 60% (n = 818) had only MDD, 7% (n = 101) only mania, and 33% (n = 428) had both. Of the comorbid group, 29% (n = 126) developed depression before mania, 39% (n = 172) developed both concurrently, and 32% (n = 140) had mania before depression. Average age of onset was 5.9 ± 4.4 years for mania and 7.4 ± 4.2 years for depression.

Discussion

The results highlight irregularity in the trajectory of depression and mania in youth. Without biomarkers, clinical acumen is necessary to distinguish between the two. Given the high consequences of misdiagnosis, including manic switch, great care must be taken in prescribing. By illustrating the chronology of mood symptoms, we aim to support clinicians in the diagnostic process.

重度抑郁症（MDD）和双相情感障碍（BPD）是儿童人群中日益普遍的衰弱性疾病。重度抑郁症和BPD通常有共同的抑郁症状，因此很难区分。尽管有这些相似之处，但治疗过程差异很大，不正确的处方会使临床过程恶化。因此，准确的诊断至关重要。更复杂的诊断是BPD最初可能表现为抑郁、躁狂或两者兼而有之。然而，研究障碍发展过程的文献有限。这是一项自然队列研究，旨在确定症状的主要模式以及随着时间的推移与重度抑郁症和BPD发展的关系。方法对1991-2008年2947例3 - 17岁儿童精神药理学项目连续转诊的患者进行精神病学访谈（K-SADS-E）横断面评估。结果46% （n = 1357）的样本符合抑郁和/或躁狂症的标准。其中，60% （n = 818）仅患有重度抑郁症，7% （n = 101）仅患有躁狂症，33% （n = 428）两者兼有。在共病组中，29% （n = 126）在躁狂之前出现抑郁，39% （n = 172）同时出现这两种症状，32% （n = 140）在抑郁之前出现躁狂。躁狂的平均发病年龄为5.9±4.4岁，抑郁的平均发病年龄为7.4±4.2岁。结果强调了青少年抑郁和躁狂症发展轨迹的不规律性。如果没有生物标志物，临床敏锐度是区分两者的必要条件。考虑到误诊的高后果，包括躁狂转换，在开处方时必须非常小心。通过说明情绪症状的年表，我们的目标是在诊断过程中支持临床医生。

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引用次数: 0

Light therapy in seasonal affective disorder: a systematic review and meta-analysis of randomized controlled and crossover trials 季节性情感障碍的光疗：随机对照和交叉试验的系统回顾和荟萃分析

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-01-03 DOI: 10.1016/j.jadr.2025.101021

Chiung-Jane Wu , Doreen Phiri , Hsiu-Ju Jen , Anggi Setyowati , Min-Huey Chung

Background

The efficacy of light therapy for seasonal affective disorder (SAD) has been supported in several studies. However, the duration of the effectiveness of light therapy at different time points has not been robustly examined.

Objective

To investigate the effect of light therapy at different time points of treatment and at post-treatment follow-up among individuals with seasonal affective disorder.

Design

A meta-analysis of randomized controlled and crossover trials.

Method

Articles were searched in nine electronic databases from inception to April 2025, and 17 eligible randomized controlled trials and crossover trials were included. The risk of bias for each included study was assessed using the criteria in the Cochrane Handbook for Systematic Reviews of Interventions, Version 2.0.

Results

Light therapy significantly reduced symptoms of seasonal affective disorder during week 2 (Hedges’ g = -0.62, p < 0.001), while the effect at weeks 1, 3, and 4 were non-significant (g = -0.17, p = 0.066, g = -0.60, p = 0.134, g = -0.15, p = 0.313). These effects correspond to estimated reductions of approximately 0.8, 3.1, 3.05, and 0.8 points, respectively, on the SIGH-SAD scale. At 1-week post-treatment follow-up, the maintenance effects of light therapy were not statistically significant for either 1-week (g = -0.52, p = 0.078) or 2-week (g = -0.36, p = 0.090) treatment durations. Measurement period was the significant moderator at week 2.

Conclusion

Light therapy can reduce symptoms of seasonal affective disorder, with a minimum of two weeks recommended to achieve desirable outcomes.

背景：光疗治疗季节性情感障碍（SAD）的疗效已得到多项研究的支持。然而，光疗在不同时间点的有效性持续时间尚未得到有力的检验。目的探讨光疗在不同治疗时间点及治疗后随访对季节性情感障碍患者的影响。设计随机对照试验和交叉试验的荟萃分析。方法检索9个电子数据库自创刊至2025年4月的文献，纳入17项符合条件的随机对照试验和交叉试验。每个纳入研究的偏倚风险采用Cochrane干预措施系统评价手册2.0版中的标准进行评估。结果光疗在第2周显著减轻了季节性情感障碍的症状（Hedges ' g = -0.62, p < 0.001），而在第1、3和4周效果不显著（g = -0.17, p = 0.066, g = -0.60, p = 0.134, g = -0.15, p = 0.313）。这些影响对应于在叹息-悲伤量表上分别减少大约0.8、3.1、3.05和0.8个点。在治疗后1周的随访中，光疗在1周（g = -0.52, p = 0.078）和2周（g = -0.36, p = 0.090）治疗期间的维持效果均无统计学意义。测量期在第2周显著调节。结论光疗可减轻季节性情感障碍的症状，建议至少两周即可达到理想效果。

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引用次数: 0

Language influences perception of impulsive tendencies of depressed individuals 语言影响抑郁个体对冲动倾向的感知

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jadr.2026.101040

Huaixuan “Knox” Huang, Kristi Erdal

Background

Impulsivity, particularly when triggered by emotions, is a significant predictor of various forms of psychopathology. However, most impulsivity research has been conducted in Western cultures. This study assessed whether culture influences perception of a depressed individual’s impulsive behavioral tendencies.

Methods

Vignettes of depressed individuals were used to examine 124 bilingual people’s (English and Japanese or Korean or Mandarin) (M_age=32.37 years; 57% male) perception of a depressed individual’s impulsivity, when language and vignette character name were varied. Impulsivity perception was measured using the five subscales of the UPPS-P Impulsive Behavior Scale - Short Form. Acculturation and self-construal were covaried.

Results

Reading and thinking in East Asian languages (compared to English) led to a depressed individual being perceived as more likely to lose control under negative emotion, to seek sensation, and to not think before acting. When the vignette character had a typical English name, participants perceived them as less likely to persevere. Acculturation and self-construal were not significant covariates.

Limitations

One impulsivity subscale was dropped due to its poor reliability in two East Asian Languages. Ecological validity was restricted by the vignette methodology, the assessment of impulsivity perception rather than behavior, and the geographical distribution of the sample.

Conclusions

Findings support how culture influences perception of impulsive tendencies of depressed individuals differently when thinking about a cultural context (name) and when thinking within a cultural context (language).

背景：冲动性，尤其是由情绪引发的冲动性，是各种形式精神病理的重要预测指标。然而，大多数关于冲动的研究都是在西方文化中进行的。本研究评估文化是否会影响抑郁症患者对冲动行为倾向的认知。方法采用抑郁个体小插图，对124名双语者（英语、日语、韩语、普通话）（年龄32.37岁，男性57%）在不同语言和小插图人物名称下对抑郁个体冲动的感知进行研究。冲动性知觉使用UPPS-P冲动性行为量表的五个子量表进行测量。文化适应与自我建构共变。结果用东亚语言阅读和思考（与用英语相比）会让抑郁的人被认为更容易在负面情绪下失去控制，更容易寻求刺激，更容易在行动前不思考。当小插图人物有一个典型的英文名字时，参与者认为他们不太可能坚持下去。文化适应和自我建构不是显著的协变量。一个冲动性分量表因其在两种东亚语言中的可靠性较差而被删除。生态效度受到小插图方法、冲动感知评估而非行为评估以及样本地理分布的限制。结论：研究结果支持了文化对抑郁症个体冲动倾向感知的影响，即在思考文化背景（名字）和在文化背景（语言）中思考时是不同的。

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引用次数: 0

Longitudinal associations between service member problematic anger and marital dysfunction in U.S. military couples: Findings from the Millennium Cohort Program 美国军人夫妇的服役人员问题愤怒和婚姻功能障碍之间的纵向联系：来自千年队列项目的发现

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.jadr.2026.101034

Travis N. Ray , Matthew P. Forsstrom , Rayan Joneydi , Cynthia A. LeardMann , Valerie A. Stander , Hope S. McMaster

Problematic anger is prevalent among service members and is associated with numerous dysfunctional outcomes. Research is needed to determine whether service member problematic anger has a unique, long-term impact on marital functioning. This study examined problematic anger and its longitudinal associations with marital dysfunction outcomes among 3456 U.S. service member–spouse dyads enrolled in the Millennium Cohort Program. Service members completed a self-report measure of problematic anger at Time 1 (2014–2016); spouses completed self-report assessments of intimate partner violence (IPV), marital quality, marital dissolution, relationship trust, and parenting alliance at Time 2 (2019–2021). Logistic regressions were conducted to examine associations between service member problematic anger and marital dysfunction outcomes using hierarchical adjustment for categories of covariates. Service member problematic anger was associated with IPV experience, low martial quality, marital dissolution, and low relationship trust among spouses after adjusting for demographic characteristics and military contextual variables. However, after adjusting for mental health variables, IPV was the only marital dysfunction outcome associated with service member problematic anger. The association between problematic anger and IPV remained after adjusting for adverse childhood experiences in the final model. Results suggest that mental health conditions, in general, may contribute to marital dysfunction in military couples, but problematic anger appears to be particularly crucial in predicting IPV. Screenings and targeted interventions for problematic anger among service members are needed. Such efforts may help to mitigate the downstream effects of problematic anger on marital dysfunction, thus improving service member readiness.

问题性愤怒在服役人员中普遍存在，并与许多功能失调的结果有关。需要研究来确定服役人员的问题性愤怒是否对婚姻功能有独特的、长期的影响。这项研究调查了3456名参加千禧年队列计划的美国军人配偶二人组的问题性愤怒及其与婚姻功能障碍结果的纵向关联。服役人员在时间1完成了问题愤怒的自我报告测量（2014-2016）；配偶在时间2（2019-2021）完成亲密伴侣暴力（IPV）、婚姻质量、婚姻解散、关系信任和育儿联盟的自我报告评估。采用Logistic回归方法对协变量类别进行分层调整，检验服役人员问题性愤怒与婚姻功能障碍结果之间的关系。在调整了人口统计学特征和军事背景变量后，服役人员问题性愤怒与IPV经历、低军事素质、婚姻破裂和配偶间低关系信任相关。然而，在调整了心理健康变量后，IPV是唯一与服役人员问题愤怒相关的婚姻功能障碍结果。在最终模型中调整了不良童年经历后，问题性愤怒和IPV之间的联系仍然存在。研究结果表明，一般来说，心理健康状况可能会导致军人夫妇的婚姻功能障碍，但问题性愤怒似乎在预测IPV方面尤为重要。需要对服役人员的问题性愤怒进行筛查和有针对性的干预。这些努力可能有助于减轻有问题的愤怒对婚姻功能障碍的下游影响，从而提高服役人员的准备程度。

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引用次数: 0

Real-world effectiveness of self-administered transcranial direct current stimulation (tDCS) for depression: A retrospective cohort study 自我给予经颅直流电刺激（tDCS）治疗抑郁症的实际有效性：一项回顾性队列研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jadr.2026.101044

Mu Mu , Aria Banazadeh , Michael Cauchi , Chris Griffiths

Background

Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by users at home. The retrospective analysis examined real-world usage and effectiveness of Flow tDCS treatment using data from 14,726 users collected by Flow Neuroscience AB between 2020 and 2024.

Methods

Self-reported user background information and Montgomery-Åsberg Depression Rating Scale Self (MADRS-S) scores up to week 50 of the treatment were analysed. Effectiveness metrics (remission, response, and relapse rates) were assessed at pre-treatment baseline followed by week 3, 6, 10, 15, 20, and 50. Repeated-measures ANOVA, post-hoc and between-subject analysis were used to examine the change in MADRS-S over time and the influence of user background factors.

Outcomes

The reported mean MADRS-S score decreased from a moderate level before treatment to a mild level at week 10 and then plateaued thereafter. Response and remission rates increased between week 3 and week 10, then stabilised through to week 50. A repeated measures ANOVA and post-hoc test reveal statistically significant differences (p < 0.0001) in MADRS-S scores across multiple time points. Reduction in reported depressive symptoms was observed during the initial weeks of treatment, these levels were maintained throughout the subsequent weeks. User adherence and background factors were significantly associated (p ≤ 0.005) with changes in MADRS-S scores during the first 10 weeks of treatment.

Interpretations

Users of self-administered Flow tDCS treatment reported a rapid initial improvement and long-term reduction of depressive symptoms. Observed variability in adherence and response across diverse user groups suggests potential benefits from personalised treatment protocols and support.

BackgroundFlow FL-100是一种经颅直流电刺激（tDCS）装置，由用户在家中自行管理。这项回顾性分析使用了2020年至2024年间由Flow Neuroscience AB收集的14726名用户的数据，研究了Flow tDCS治疗的实际使用情况和有效性。方法对治疗第50周前自述使用者背景信息和Montgomery-Åsberg抑郁评定量表（MADRS-S）评分进行分析。有效性指标（缓解、反应和复发率）在治疗前基线进行评估，随后是第3、6、10、15、20和50周。使用重复测量方差分析、事后分析和受试者间分析来检查MADRS-S随时间的变化以及用户背景因素的影响。结果：报告的平均MADRS-S评分从治疗前的中等水平下降到第10周的轻度水平，随后趋于稳定。缓解率和缓解率在第3周和第10周之间增加，然后稳定到第50周。重复测量方差分析和事后检验显示，MADRS-S评分在多个时间点上存在统计学显著差异（p < 0.0001）。在治疗的最初几周内，观察到报告的抑郁症状减轻，这些水平在随后的几周内保持不变。使用者依从性和背景因素与治疗前10周MADRS-S评分的变化显著相关（p≤0.005）。自我给予Flow tDCS治疗的患者报告了抑郁症状的快速初步改善和长期减轻。在不同用户群体中观察到的依从性和反应的可变性表明个性化治疗方案和支持的潜在益处。

{"title":"Real-world effectiveness of self-administered transcranial direct current stimulation (tDCS) for depression: A retrospective cohort study","authors":"Mu Mu , Aria Banazadeh , Michael Cauchi , Chris Griffiths","doi":"10.1016/j.jadr.2026.101044","DOIUrl":"10.1016/j.jadr.2026.101044","url":null,"abstract":"<div><h3>Background</h3><div>Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by users at home. The retrospective analysis examined real-world usage and effectiveness of Flow tDCS treatment using data from 14,726 users collected by Flow Neuroscience AB between 2020 and 2024.</div></div><div><h3>Methods</h3><div>Self-reported user background information and Montgomery-Åsberg Depression Rating Scale Self (MADRS-S) scores up to week 50 of the treatment were analysed. Effectiveness metrics (remission, response, and relapse rates) were assessed at pre-treatment baseline followed by week 3, 6, 10, 15, 20, and 50. Repeated-measures ANOVA, post-hoc and between-subject analysis were used to examine the change in MADRS-S over time and the influence of user background factors.</div></div><div><h3>Outcomes</h3><div>The reported mean MADRS-S score decreased from a moderate level before treatment to a mild level at week 10 and then plateaued thereafter. Response and remission rates increased between week 3 and week 10, then stabilised through to week 50. A repeated measures ANOVA and post-hoc test reveal statistically significant differences (<em>p</em> < 0.0001) in MADRS-S scores across multiple time points. Reduction in reported depressive symptoms was observed during the initial weeks of treatment, these levels were maintained throughout the subsequent weeks. User adherence and background factors were significantly associated (<em>p</em> ≤ 0.005) with changes in MADRS-S scores during the first 10 weeks of treatment.</div></div><div><h3>Interpretations</h3><div>Users of self-administered Flow tDCS treatment reported a rapid initial improvement and long-term reduction of depressive symptoms. Observed variability in adherence and response across diverse user groups suggests potential benefits from personalised treatment protocols and support.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101044"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thwarted belongingness as a predictor of suicidal ideation: A question of operationalization? 被挫败的归属感作为自杀意念的预测因子：操作化的问题？

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-01-16 DOI: 10.1016/j.jadr.2026.101025

J. Eimen , H. Schiemann , J.J. Schroers , I. Höller , D. Schreiber , T. Teismann , T. Forkmann

Introduction

The Interpersonal Theory of Suicide (ITS) posits that thwarted belongingness (TB), perceived burdensomeness (PB), and hopelessness about the unchangeability of both states predict suicidal ideation, with TB often being a weaker predictor compared to PB. This study evaluates the German version of the Thwarted Belongingness Scale (TBS) as an alternative to the Interpersonal Needs Questionnaire (INQ) for operationalizing TB.

Methods

411 participants (75.4% female; M_age = 29.57; SD_age = 11.20) completed an online survey. Factorial validity of the TBS was examined using confirmatory factor analysis. Internal consistency and convergent validity were investigated. Hierarchical linear regression analyses compared TBS and INQ in predicting suicidal ideation, including PB and the interaction of TB×PB as predictors.

Results

The TBS demonstrated excellent internal consistency (Cronbach’s α = 0.95), good fit indices, and convergent validity. Both TBS and INQ significantly predicted suicidal ideation, but no interaction effect of TB×PB was found. PB was a significantly stronger predictor of suicidal ideation than TB, regardless of TB measure used.

Conclusion

The TBS showed solid psychometric properties and may be a suitable alternative to the INQ for measuring TB. However, TB remains a weaker predictor of suicidal ideation compared to PB, regardless of operationalization, suggesting the need to reassess the role of TB in suicide theories.

人际自杀理论（ITS）认为，受挫的归属感（TB）、感知到的负担感（PB）和对两种状态不变的绝望可以预测自杀意念，与PB相比，TB通常是一个较弱的预测因子。本研究评估了德国版的受挫归属感量表（TBS）作为人际需求问卷（INQ）的替代方案来实施TB。方法411名参与者（女性75.4%,Mage = 29.57, SDage = 11.20）完成在线调查。采用验证性因子分析检验TBS的析因效度。研究了内部一致性和收敛效度。层次线性回归分析比较TBS和INQ对自杀意念的预测，包括PB和TB×PB的相互作用作为预测因子。结果量表具有良好的内部一致性（Cronbach’s α = 0.95），拟合指标良好，具有收敛效度。TBS和INQ对自杀意念均有显著预测作用，但TB×PB无交互作用。无论采用何种结核病测量方法，PB对自杀意念的预测都明显强于结核病。结论TBS具有较强的心理测量特性，可替代INQ作为结核病的测量方法。然而，与PB相比，结核仍然是一个较弱的自杀意念预测因子，无论操作方式如何，这表明需要重新评估结核在自杀理论中的作用。

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引用次数: 0

Mental health in adults aged 50+ since the COVID-19 pandemic: Are we (all) back to ‘normal’? evidence from England 自COVID-19大流行以来50岁以上成年人的心理健康：我们（所有人）是否恢复了“正常”？来自英格兰的证据

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2025-12-20 DOI: 10.1016/j.jadr.2025.101012

Darío Moreno-Agostino , Giorgio Di Gessa

Objectives

To understand how population mental health levels and inequalities in these are in the post-lockdown world compared to before the pandemic in adults aged 50 and older.

Methods

We used data from three Waves (2016–2017, n = 7191; 2018–2019, n = 7286; and 2021–2023, n = 6249) of the English Longitudinal Study of Ageing. Using linear and modified Poisson regression models, we investigated whether prevalence of high depressive symptomatology, anxiety, and loneliness, and quality-of-life levels changed across time points overall and by gender, living situation, and wealth quintiles. Models were adjusted for age group, gender, education, and long-standing illnesses.

Results

No significant differences were found between 2016–2017 and 2018–2019. However, compared to 2018–2019, prevalence of high depressive symptoms (RR_2021–2023 = 1.23[95 %CI 1.12;1.34], p < 0.001), loneliness (RR_2021–2023 = 1.32[1.22;1.42], p < 0.001) and quality-of-life levels (B_2021–2023 = -1.84 [-2.21;-1.48], p < 0.001) were worse by 2021–2023. Pre-existing inequalities by gender, living arrangements, and wealth were not significantly different after the pandemic, except for depression, where gaps were significantly smaller by gender (RR_{2021–2023*women} = 0.72[0.59;0.89], p = 0.002) and, to a smaller extent, living situation (RR_{2021–2023*not_alone}=1.22[1.02;1.47], p = 0.026).

Conclusion

Population mental health levels in the population aged 50 and older seem to have declined after the pandemic, and inequalities within the population persist.

目的了解封锁后与大流行前相比，50岁及以上成年人的心理健康水平和不平等情况。方法采用英国老龄化纵向研究的三期（2016-2017年，n = 7191； 2018-2019年，n = 7286； 2021-2023年，n = 6249）数据。使用线性和修正泊松回归模型，我们调查了高抑郁症状、焦虑和孤独的患病率以及生活质量水平是否在整体时间点、性别、生活状况和财富五分位数之间发生变化。模型根据年龄组、性别、教育程度和长期疾病进行了调整。结果2016-2017年与2018-2019年无显著差异。然而，与2018-2019年相比，2021-2023年高抑郁症状（RR2021-2023 = 1.23[95% CI 1.12;1.34], p < 0.001）、孤独感（RR2021-2023 = 1.32[1.22;1.42], p < 0.001）和生活质量水平（B2021-2023 = -1.84 [-2.21;-1.48], p < 0.001）的患病率更差。大流行之后，性别、生活安排和财富方面存在的不平等现象没有显著差异，但抑郁症方面的性别差距明显较小（RR2021-2023 *women = 0.72[0.59;0.89], p = 0.002），生活状况方面的差距较小（RR2021-2023 *not_alone=1.22[1.02;1.47], p = 0.026）。结论大流行后，50岁及以上人群的心理健康水平似乎有所下降，人群内部的不平等现象仍然存在。

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引用次数: 0

State-dependent alterations in circulating mitochondrial DNA copy number and common deletion in bipolar disorder 双相情感障碍中循环线粒体DNA拷贝数和常见缺失的状态依赖性改变

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.jadr.2026.101031

Yuki Kageyama , Shohei Okura , Yasuhiko Deguchi , Kenji Kuroda , Koki Inoue

Background

Mitochondrial dysfunction has been increasingly implicated in the pathophysiology of bipolar disorder (BD), and circulating mitochondrial DNA (mtDNA) has emerged as a potential biomarker. However, the biological significance of distinct circulating forms, structural abnormalities, and their association with inflammatory cytokines remains unclear. This study aimed to (1) quantify plasma mtDNA and extracellular vesicle-associated mtDNA (EV mtDNA), examine their correlations, and assess associations with interleukin-6 (IL-6), and (2) evaluate state-dependent alterations in the 4977-bp common deletion.

Methods

Twenty-one paired plasma samples were collected longitudinally from BD patients during depressive (dBD) and remitted (rBD) states. Plasma and EV mtDNA copy numbers and the 4977-bp common deletion were quantified using multiplex qPCR. Plasma IL-6 levels were measured by ELISA. Data were normalized using median normalization.

Results

Plasma and EV mtDNA copy numbers were significantly reduced in dBD compared with rBD (P_FDR < 0.01 for both). In contrast, ND4/ND1 ratio was significantly lower in dBD in both plasma and EV fractions (P_FDR < 0.001 for both). Plasma and EV mtDNA levels were strongly correlated in both states, with EV mtDNA comprising ∼30% of total circulating mtDNA. Plasma IL-6 levels were decreased in dBD (P_FDR < 0.01) but showed no significant correlations with mtDNA measures.

Conclusion

Depressive states in BD are associated with reduced circulating mtDNA copy number and increased common deletion compared with remission. Combined assessment of mtDNA abundance and integrity across extracellular compartments may represent a novel biomarker strategy for state-dependent mitochondrial dysfunction in BD.

线粒体功能障碍越来越多地与双相情感障碍（BD）的病理生理有关，循环线粒体DNA （mtDNA）已成为一种潜在的生物标志物。然而，不同循环形式、结构异常及其与炎症细胞因子的关联的生物学意义尚不清楚。本研究旨在(1)量化血浆mtDNA和细胞外囊泡相关mtDNA (EV mtDNA)，检查它们之间的相关性，并评估与白细胞介素-6 （IL-6）的相关性，以及(2)评估4977 bp常见缺失的状态依赖性改变。方法纵向采集抑郁（dBD）和缓解（rBD）双相BD患者血浆样本21份。采用多重qPCR定量分析血浆和EV mtDNA拷贝数以及4977 bp的常见缺失。ELISA法检测血浆IL-6水平。数据采用中位数归一化进行归一化。结果与rBD相比，dBD患者血浆和EV mtDNA拷贝数显著减少（两者的P_FDR <； 0.01）。相比之下，血浆和EV中ND4/ND1比值在dBD中均显著降低（两者的P_FDR <； 0.001）。在这两种状态下，血浆和EV mtDNA水平密切相关，EV mtDNA占总循环mtDNA的约30%。血浆IL-6水平在dBD时降低（P_FDR < 0.01），但与mtDNA水平无显著相关性。结论与缓解期相比，双相障碍患者抑郁状态与循环mtDNA拷贝数减少和常见缺失增加有关。综合评估细胞外区室的mtDNA丰度和完整性可能代表一种新的生物标志物策略，用于诊断双相障碍患者的状态依赖性线粒体功能障碍。

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引用次数: 0

Effectiveness and the patient experience with vortioxetine vs other standard-of-care antidepressants in major depressive disorder: Real-world insights from an observational, prospective, decentralized study using the PatientsLikeMe platform 沃替西汀与其他标准抗抑郁药在重度抑郁症中的疗效和患者体验：使用PatientsLikeMe平台进行的一项观察性、前瞻性、分散研究的真实世界见解

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-04-01 Epub Date: 2026-01-09 DOI: 10.1016/j.jadr.2025.101019

Jeoffrey Bispham , Christopher Blair , Sagar V. Parikh , Roger S. McIntyre , Mark Opler , Erlyn Macarayan , Mary C. Burke , Alina Karim , Michael Martin , Priscilla Driscoll Shempp , Ian Robinson , Maggie McCue

Background

Major depressive disorder (MDD) remains a clinical challenge, showing low remission rates with standard-of-care (SOC) antidepressants (ADs). This study evaluated real-world treatment experience with vortioxetine vs SOC ADs through the online peer community PatientsLikeMe (PLM).

Methods

This observational, prospective, patient-centric, decentralized study recruited adults with MDD using the PLM platform. In this 2-part study, qualitative surveys informed study flow. The quantitative study enrolled participants who started or switched SOC AD monotherapy or vortioxetine within 180 days and had baseline Patient Health Questionnaire-9 scores ≥5. Primary endpoint was proportion with Patient Global Impression of Improvement (PGI-I) score <2 at week 12 (W12). Secondary endpoints included MDD severity, MDD symptoms, and quality of life (QoL).

Results

Qualitative survey responses refined the quantitative study design. Quantitative study enrolled 352 receiving SOC and 151 receiving vortioxetine. At W12, proportions with PGI-I scores <2 were similar (vortioxetine vs SOC: 4.5% vs 1.8%; P = 0.830). Mean PGI-I scores were similar at W12 (vortioxetine vs SOC: 3.5 vs 3.6; P = 0.831) and lower with vortioxetine at W24 (vortioxetine vs SOC: 3.0 vs 3.4; P < 0.001). Remission rates at W24 were higher with vortioxetine (11.4%) vs SOC (2.5%; P < 0.001). Feelings of anhedonia were significantly less frequent with vortioxetine (P = 0.005).

Limitations

Self-reported data may introduce recall bias. PLM users may have higher health literacy than the general population.

Conclusions

Although primary endpoint was not met, long-term vortioxetine was associated with improved global impression, QoL and life satisfaction, and a higher rate of remission, which can guide clinical decisions and empower patients.

重度抑郁症（MDD）仍然是一个临床挑战，使用标准治疗（SOC）抗抑郁药（ADs）的缓解率很低。本研究通过在线同行社区PatientsLikeMe （PLM）评估了沃替西汀与SOC ad的真实治疗体验。方法：这项观察性、前瞻性、以患者为中心、分散的研究使用PLM平台招募成年重度抑郁症患者。在这个由两部分组成的研究中，定性调查告知了研究流程。定量研究纳入了在180天内开始或转换SOC AD单药治疗或沃替西汀的参与者，并且基线患者健康问卷-9得分≥5。主要终点是第12周（W12）患者总体改善印象（PGI-I）评分<；2的比例。次要终点包括MDD严重程度、MDD症状和生活质量（QoL）。结果定性调查结果完善了定量研究设计。定量研究入组352例接受SOC治疗，151例接受vortioxetine治疗。在W12时，pg - i评分为<；2的比例相似（vortioxetine vs SOC: 4.5% vs 1.8%; P = 0.830）。在W12时，平均gi - i评分相似（沃替西汀与SOC: 3.5 vs 3.6; P = 0.831），而在W24时，沃替西汀的评分较低（沃替西汀与SOC: 3.0 vs 3.4; P < 0.001）。沃替西汀组的缓解率（11.4%）高于SOC组（2.5%;P < 0.001）。沃替西汀组的快感缺乏症发生率明显降低（P = 0.005）。局限性：自我报告的数据可能会引入回忆偏差。PLM用户的健康素养可能高于一般人群。结论长期使用沃替西汀虽未达到主要终点，但总体印象、生活质量和生活满意度均有所改善，缓解率较高，可指导临床决策，赋予患者权力。

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引用次数: 0

The protective role of heart rate variability against ruminative thoughts in university students accessing Psychological Support Services 心率变异性对大学生心理支持服务中反刍思维的保护作用

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01 Epub Date: 2025-12-31 DOI: 10.1016/j.jadr.2025.101017

Tania Moretta , Carola Dell’Acqua , Elisabetta Patron , Gioia Bottesi , Giulia Demo , Giulia Buodo , Daniela Palomba

Background

University students have a high likelihood of developing depressive symptoms. To counteract the increasing demand for psychological support, university clinical services are developing assessment protocols aimed at improving the early identification of mental disorders. In this context, psychological features (e.g., rumination) and altered autonomic balance (e.g., low heart rate variability, HRV) are well-established predictors of the onset and exacerbation of depressive symptoms.

Objective

The present study aimed to explore the reciprocal interaction between rumination and HRV in predicting the severity of depressive symptoms among university students accessing Psychological Support Services (PSS) for emotional distress (support-seeking group) has been compared to a group drawn from the general population of college students outside of PSS (control group).

Method

Thirty-six (26 F) support-seeking students and 39 (28 F) controls completed the Beck Depression Inventory, the Beck Anxiety Inventory, and the Rumination Response Scale. HRV was measured through a smartphone app during a guided online meeting with a trained researcher.

Results

The main results indicated a statistically significant interaction between levels of rumination and HRV in predicting depressive symptoms among support-seeking students, suggesting that increased HRV may buffer the impact of rumination on depressive symptoms.

Conclusion

These results highlight the important role of multidimensional assessment protocols that include psychological and physiological measures, for the selective identification of risk of developing anxiety and depression among university students. Interventions could include self-regulation training aimed at improving cardiac vagal control to counteract the negative effect of rumination on the exacerbation of depressive symptoms.

大学生很有可能出现抑郁症状。为了应对日益增长的心理支持需求，大学临床服务部门正在制定评估方案，旨在改善对精神障碍的早期识别。在这种情况下，心理特征（如反刍）和改变的自主神经平衡（如低心率变异性，HRV）是公认的抑郁症状发生和恶化的预测因素。目的探讨反刍和HRV在预测因情绪困扰而获得心理支持服务（PSS）的大学生（支持寻求组）抑郁症状严重程度中的相互作用，并将其与非PSS的大学生（对照组）进行比较。方法36例（26 F）寻求支持学生和39例（28 F）对照完成贝克抑郁量表、贝克焦虑量表和反刍反应量表。HRV是在与训练有素的研究人员进行指导的在线会议期间通过智能手机应用程序测量的。结果反刍与HRV水平对寻求支持学生抑郁症状的预测存在显著的交互作用，表明HRV的升高可以缓冲反刍对抑郁症状的影响。结论综合心理和生理指标的多维度评估方案在选择性识别大学生焦虑和抑郁风险方面具有重要作用。干预措施可能包括旨在改善心脏迷走神经控制的自我调节训练，以抵消反刍对抑郁症状加剧的负面影响。

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引用次数: 0