Pub Date : 2025-01-11DOI: 10.1016/j.jadr.2024.100868
Jamee Guerra Valencia , Akram Hernández-Vásquez , Rodrigo Vargas-Fernández
Background
Previous studies on the relationship between body composition and depressive symptoms have focused on fat or lean mass separately. We aimed to examine the association between the lean-to-fat mass ratio (LFMR) and depressive symptoms in the adult Peruvian population.
Methods
This cross-sectional study used the Peruvian Demographic and Health Survey 2023. Adults aged 18–59 years were included, while pregnant women and individuals with implausible anthropometric measurements were excluded. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), while the exposure variable, the LFMR, was calculated using validated regression equations derived from the National Health and Nutrition Examination Survey (NHANES) database, which included the Latino population. Nested regression models assessed the relationship between the LFMR and depressive symptoms, including linear and quadratic terms. Models were adjusted for sociodemographic, health, and behavioral factors. Marginal effects of LFMR were plotted.
Results
24,674 subjects were included. A non-linear association between LFMR and depressive symptoms, with a J-shaped curve was found. An initial decrease in depressive symptoms score with increasing LFMR was observed in the adjusted model (β: −1.89; 95 %CI: −2.24, −1.54), followed by an increase in PHQ-9 score at higher LFMR values (β: 0.23; 95 %CI: 0.18, 0.28).
Limitations
Lean and fat mass were estimated via equations rather than direct measurements.
Conclusions
These results underscore a non-linear association between the LFMR and depressive symptoms among Peruvian adults. An optimal balance between lean and fat mass, rather than focusing solely on one component, may be crucial in reducing depressive symptoms.
{"title":"Association between the lean-to-fat mass ratio and depressive symptoms in adult Peruvian population: A cross-sectional analysis","authors":"Jamee Guerra Valencia , Akram Hernández-Vásquez , Rodrigo Vargas-Fernández","doi":"10.1016/j.jadr.2024.100868","DOIUrl":"10.1016/j.jadr.2024.100868","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies on the relationship between body composition and depressive symptoms have focused on fat or lean mass separately. We aimed to examine the association between the lean-to-fat mass ratio (LFMR) and depressive symptoms in the adult Peruvian population.</div></div><div><h3>Methods</h3><div>This cross-sectional study used the Peruvian Demographic and Health Survey 2023. Adults aged 18–59 years were included, while pregnant women and individuals with implausible anthropometric measurements were excluded. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), while the exposure variable, the LFMR, was calculated using validated regression equations derived from the National Health and Nutrition Examination Survey (NHANES) database, which included the Latino population. Nested regression models assessed the relationship between the LFMR and depressive symptoms, including linear and quadratic terms. Models were adjusted for sociodemographic, health, and behavioral factors. Marginal effects of LFMR were plotted.</div></div><div><h3>Results</h3><div>24,674 subjects were included. A non-linear association between LFMR and depressive symptoms, with a J-shaped curve was found. An initial decrease in depressive symptoms score with increasing LFMR was observed in the adjusted model (β: −1.89; 95 %CI: −2.24, −1.54), followed by an increase in PHQ-9 score at higher LFMR values (β: 0.23; 95 %CI: 0.18, 0.28).</div></div><div><h3>Limitations</h3><div>Lean and fat mass were estimated via equations rather than direct measurements.</div></div><div><h3>Conclusions</h3><div>These results underscore a non-linear association between the LFMR and depressive symptoms among Peruvian adults. An optimal balance between lean and fat mass, rather than focusing solely on one component, may be crucial in reducing depressive symptoms.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100868"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1016/j.jadr.2025.100873
Verinder Sharma , Katelyn N. Wood
Background
Women with bipolar I disorder are at a high risk of recurrence postpartum. This case series describes the postpartum course of bipolar I disorder among women receiving optimized treatment aimed specifically at the prevention of mania.
Methods
Clinical records of 12 pregnant females with bipolar I disorder who were seen consecutively at a perinatal clinic between 2020 and 2023 were reviewed to assess the effect of treatment including psychoeducation, good sleep hygiene, avoidance of antidepressants, and use of sedating atypical antipsychotics on postpartum recurrence.
Results
All except one patient had been hospitalized for bipolar disorder. The mean follow-up period was 56 ± 73 weeks postpartum. Only two patients (16.7 %) had a relapse (both depression) during the postpartum period. No one required psychiatric hospitalization.
Limitations
Small sample size, retrospective design, and lack of comparison group.
Conclusion
Combining psychoeducation, social rhythm therapy, and targeted pharmacotherapy may be effective in the prevention of postpartum recurrence in women with bipolar I disorder.
{"title":"Effect of optimized treatment on the postpartum recurrence in women with bipolar I disorder: A case series","authors":"Verinder Sharma , Katelyn N. Wood","doi":"10.1016/j.jadr.2025.100873","DOIUrl":"10.1016/j.jadr.2025.100873","url":null,"abstract":"<div><h3>Background</h3><div>Women with bipolar I disorder are at a high risk of recurrence postpartum. This case series describes the postpartum course of bipolar I disorder among women receiving optimized treatment aimed specifically at the prevention of mania.</div></div><div><h3>Methods</h3><div>Clinical records of 12 pregnant females with bipolar I disorder who were seen consecutively at a perinatal clinic between 2020 and 2023 were reviewed to assess the effect of treatment including psychoeducation, good sleep hygiene, avoidance of antidepressants, and use of sedating atypical antipsychotics on postpartum recurrence.</div></div><div><h3>Results</h3><div>All except one patient had been hospitalized for bipolar disorder. The mean follow-up period was 56 ± 73 weeks postpartum. Only two patients (16.7 %) had a relapse (both depression) during the postpartum period. No one required psychiatric hospitalization.</div></div><div><h3>Limitations</h3><div>Small sample size, retrospective design, and lack of comparison group.</div></div><div><h3>Conclusion</h3><div>Combining psychoeducation, social rhythm therapy, and targeted pharmacotherapy may be effective in the prevention of postpartum recurrence in women with bipolar I disorder.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100873"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-04DOI: 10.1016/j.jadr.2025.100872
Vilde Brecke , Anders Lillevik Thorsen , Chaim Huyser , Niels de Joode , Bjarne Hansen , Kristen Hagen , Gerd Kvale , Chris Vriend , Odile A. van den Heuvel , Olga Therese Ousdal
Background
Thalamic volumetric alterations are frequently reported in children and adults with obsessive-compulsive disorder (OCD). However, whether successful cognitive behavioral therapy (CBT) is accompanied by thalamic macrostructural plasticity is unclear.
Methods
Twenty-five pediatric (8–19 years) and 53 adult (16–55 years) OCD patients underwent magnetic resonance imaging before and after CBT with exposure and response prevention (CBT with ERP). The data also included 27 pediatric and 37 adult healthy controls that were scanned at similar time intervals. Thalamic nuclei volumes were estimated from T1-weighted images using the longitudinal stream of FreeSurfer's ThalamicNuclei pipeline and aggregated into five subregions (anterior, lateral, medial, pulvinar and ventral). Repeated measures ANCOVAs and linear models were used to investigate pre-post changes in total or subregional thalamic volumes and their associations with clinical response.
Results
There were no significant changes in total or subregional thalamic volumes following CBT with ERP in the pediatric or the adult OCD patients. Moreover, the individual clinical response was not associated with changes in thalamic volume, and baseline thalamic volumes did not predict clinical outcome.
Limitations
Low variance in the clinical outcome and power to detect only moderate-to-large effect sizes.
Conclusion
The results suggest that total and subregional thalamic volumes remain stable following successful CBT with ERP in OCD patients. Hence, thalamus or its subregions may not serve as feasible biomarkers of CBT outcome in OCD.
{"title":"Total and subregional thalamic volumes before and after cognitive behavioral therapy in obsessive-compulsive disorder","authors":"Vilde Brecke , Anders Lillevik Thorsen , Chaim Huyser , Niels de Joode , Bjarne Hansen , Kristen Hagen , Gerd Kvale , Chris Vriend , Odile A. van den Heuvel , Olga Therese Ousdal","doi":"10.1016/j.jadr.2025.100872","DOIUrl":"10.1016/j.jadr.2025.100872","url":null,"abstract":"<div><h3>Background</h3><div>Thalamic volumetric alterations are frequently reported in children and adults with obsessive-compulsive disorder (OCD). However, whether successful cognitive behavioral therapy (CBT) is accompanied by thalamic macrostructural plasticity is unclear.</div></div><div><h3>Methods</h3><div>Twenty-five pediatric (8–19 years) and 53 adult (16–55 years) OCD patients underwent magnetic resonance imaging before and after CBT with exposure and response prevention (CBT with ERP). The data also included 27 pediatric and 37 adult healthy controls that were scanned at similar time intervals. Thalamic nuclei volumes were estimated from T1-weighted images using the longitudinal stream of FreeSurfer's ThalamicNuclei pipeline and aggregated into five subregions (anterior, lateral, medial, pulvinar and ventral). Repeated measures ANCOVAs and linear models were used to investigate pre-post changes in total or subregional thalamic volumes and their associations with clinical response.</div></div><div><h3>Results</h3><div>There were no significant changes in total or subregional thalamic volumes following CBT with ERP in the pediatric or the adult OCD patients. Moreover, the individual clinical response was not associated with changes in thalamic volume, and baseline thalamic volumes did not predict clinical outcome<strong>.</strong></div></div><div><h3>Limitations</h3><div>Low variance in the clinical outcome and power to detect only moderate-to-large effect sizes.</div></div><div><h3>Conclusion</h3><div>The results suggest that total and subregional thalamic volumes remain stable following successful CBT with ERP in OCD patients. Hence, thalamus or its subregions may not serve as feasible biomarkers of CBT outcome in OCD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100872"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-04DOI: 10.1016/j.jadr.2025.100871
Isabella Caruso , Donghao Lu , Sofija Zagarins , Elizabeth Bertone-Johnson
Background
Premenstrual disorders (PMDs) impact quality of life, increase morbidity, and impair school and work performance, affecting approximately 15–20 % of women of reproductive age. Chronic inflammation has been hypothesized to contribute to the development of PMDs and premenstrual symptoms. However, to our knowledge, few studies have studied the potential associations between premenstrual symptoms and inflammation-related conditions, specifically asthma and eczema.
Methods
We investigated the relationship of asthma and eczema with premenstrual symptom severity and PMS risk among 414 women aged 18–31. We used a modified version of the Calendar of Premenstrual Experiences to assess menstrual symptom score. Participants self-reported history of asthma and eczema, as well as their behavioral, dietary, and medical history. A sample of participants (n = 287) provided blood samples to evaluate inflammatory factor levels.
Results
We observed significant positive associations between history of asthma (n = 98) and mean total symptom and physical symptom scores. In adjusted analyses, mean total symptom scores were 2.68 (SE = 1.3) points higher among women with asthma than without (P = 0.04). Mean total symptom scores were 4.8 points higher for women reporting both asthma and eczema (n = 36) than those reporting neither condition (n = 256; P = 0.04).
Limitations
The cross-sectional study design does not allow us to establish how the timing of asthma onset is related to the timing of premenstrual symptoms.
Conclusions
Our results provide support for a relationship between asthma and premenstrual symptoms. More research is needed to understand whether allergic and other inflammatory conditions share common etiology with PMDs.
{"title":"Association of asthma and allergy history with premenstrual symptom severity in young adult women","authors":"Isabella Caruso , Donghao Lu , Sofija Zagarins , Elizabeth Bertone-Johnson","doi":"10.1016/j.jadr.2025.100871","DOIUrl":"10.1016/j.jadr.2025.100871","url":null,"abstract":"<div><h3>Background</h3><div>Premenstrual disorders (PMDs) impact quality of life, increase morbidity, and impair school and work performance, affecting approximately 15–20 % of women of reproductive age. Chronic inflammation has been hypothesized to contribute to the development of PMDs and premenstrual symptoms. However, to our knowledge, few studies have studied the potential associations between premenstrual symptoms and inflammation-related conditions, specifically asthma and eczema.</div></div><div><h3>Methods</h3><div>We investigated the relationship of asthma and eczema with premenstrual symptom severity and PMS risk among 414 women aged 18–31. We used a modified version of the Calendar of Premenstrual Experiences to assess menstrual symptom score. Participants self-reported history of asthma and eczema, as well as their behavioral, dietary, and medical history. A sample of participants (<em>n</em> = 287) provided blood samples to evaluate inflammatory factor levels.</div></div><div><h3>Results</h3><div>We observed significant positive associations between history of asthma (<em>n</em> = 98) and mean total symptom and physical symptom scores. In adjusted analyses, mean total symptom scores were 2.68 (SE = 1.3) points higher among women with asthma than without (<em>P</em> = 0.04). Mean total symptom scores were 4.8 points higher for women reporting both asthma and eczema (<em>n</em> = 36) than those reporting neither condition (<em>n</em> = 256; <em>P</em> = 0.04).</div></div><div><h3>Limitations</h3><div>The cross-sectional study design does not allow us to establish how the timing of asthma onset is related to the timing of premenstrual symptoms.</div></div><div><h3>Conclusions</h3><div>Our results provide support for a relationship between asthma and premenstrual symptoms. More research is needed to understand whether allergic and other inflammatory conditions share common etiology with PMDs.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100871"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.jadr.2024.100869
Hernán F Guillen-Burgos , Juan F Gálvez-Flórez , Sergio Moreno-Lopez , Angela T.H. Kwan , Oscar Gomez , Gerardo González-Haddad , Roger S. McIntyre
Background
Childhood trauma (CT) exposure is associated with a more pernicious course in bipolar disorder (BD). However, few studies have reported differences between BD I and BD II regarding CT exposure. We explore the differences in the CT trajectories in bipolar disorders.
Methods
A retrospective cohort study of individuals with BD (BD I = 73 vs BD II = 73) was carried out. Early age at onset (EAO) and suicide ideation/behavior were used as severity outcomes. Timespan between EAO and treatment was documented and the associations between CT and comorbid alcohol used disorder (AUD), anxiety disorders (AD), and post-traumatic stress disorder (PTSD) were also described. Univariate, bivariate analyses, and a Poisson regression model with bootstrap resampling were used.
Results
Higher scores of CT, physical abuse (PA), and sexual abuse (SA) were statistically significant for BD II than BD I (p < 0.001, p = 0.048, p < 0.001, respectively). Early age at onset, suicide ideation/behavior and treatment delay were associated with CT in both BD I and BD II. However, AUD and PTSD showed association with CT only for BD I.
Limitations
Sample size, non-comparison control group, and recall bias.
Conclusions
There are differences in CT subtype exposure between BD I and BD II with regards to early age onset, suicide ideation/behavior, delayed time to treatment, and comorbid mental disorders. These results claim for early access to strategies such as CT exposure screening in individuals with BD to detect possible pernicious course and improve the quality of life and clinical outcomes.
{"title":"Differences in bipolar disorder type I and type II exposed to childhood trauma: A retrospective cohort study","authors":"Hernán F Guillen-Burgos , Juan F Gálvez-Flórez , Sergio Moreno-Lopez , Angela T.H. Kwan , Oscar Gomez , Gerardo González-Haddad , Roger S. McIntyre","doi":"10.1016/j.jadr.2024.100869","DOIUrl":"10.1016/j.jadr.2024.100869","url":null,"abstract":"<div><h3>Background</h3><div>Childhood trauma (CT) exposure is associated with a more pernicious course in bipolar disorder (BD). However, few studies have reported differences between BD I and BD II regarding CT exposure. We explore the differences in the CT trajectories in bipolar disorders.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of individuals with BD (BD I = 73 vs BD II = 73) was carried out. Early age at onset (EAO) and suicide ideation/behavior were used as severity outcomes. Timespan between EAO and treatment was documented and the associations between CT and comorbid alcohol used disorder (AUD), anxiety disorders (AD), and post-traumatic stress disorder (PTSD) were also described. Univariate, bivariate analyses, and a Poisson regression model with bootstrap resampling were used.</div></div><div><h3>Results</h3><div>Higher scores of CT, physical abuse (PA), and sexual abuse (SA) were statistically significant for BD II than BD I (<em>p <</em> 0.001, <em>p =</em> 0.048, <em>p <</em> 0.001, respectively). Early age at onset, suicide ideation/behavior and treatment delay were associated with CT in both BD I and BD II. However, AUD and PTSD showed association with CT only for BD I.</div></div><div><h3>Limitations</h3><div>Sample size, non-comparison control group, and recall bias.</div></div><div><h3>Conclusions</h3><div>There are differences in CT subtype exposure between BD I and BD II with regards to early age onset, suicide ideation/behavior, delayed time to treatment, and comorbid mental disorders. These results claim for early access to strategies such as CT exposure screening in individuals with BD to detect possible pernicious course and improve the quality of life and clinical outcomes.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100869"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.jadr.2024.100863
Paula Ravitz , Natalie Heeney , Andrea Lawson , Edward McAnanama , Clare Pain , Alex Kiss , Priya Watson , Jan Malat , Sophie Grigoriadis , Simone Vigod , Daisy R. Singla
Background
Interpersonal Psychotherapy (IPT) is an effective depression treatment but limited numbers of trained providers result in less access than patients need. Asynchronous self-directed digital training may reduce this gap.
Methods
We developed digital IPT training and evaluated it in a pilot parallel randomized controlled trial. Psychiatry residents (N=25) in Toronto, Canada, were randomly assigned, 1:1, to an asynchronous self-directed digital course (intervention; n=13) or synchronous group training-as-usual workshop (control; n=12) and then delivered ∼12 clinically-supervised individual IPT sessions to depressed patients (N=26; 10≥PHQ9<20). The primary objective was to examine intervention feasibility and acceptability (retention, facilitators, barriers). We also examined resident competence (IPT knowledge, confidence, clinical skills, therapeutic alliances) and patient depressive outcomes (PHQ9).
Results
Resident retention in intervention (10/13; 76.9%) vs control (11/12; 91.7%) groups did not differ (p=.59). Qualitative semi-structured interviews with intervention residents (n=10) revealed that IPT's relational focus, video-recorded expert demonstrations (9/10; 90%), and case-based digital curriculum's user-friendliness (7/10; 70%) were facilitators. Half missed peer interactions in group workshops and found some interactive course elements disrupted learning. Both groups’ competence improved over time (F≥25.7, p≤.0001), with no significant between-arm differences in knowledge, confidence, skills, or therapeutic alliances (F≤1.07, p≥.31). Intervention and control patient groups improved from baseline (PHQ9=14.6 vs. 13.2; F=24.4, p=.0001), with no significant between-arm post-treatment depressive symptom differences (PHQ9=7.63 vs. 7.60, t=-0.01, p=.99).
Limitations
Small sample and provider type (psychiatry resident) limit generalizability.
Conclusion
Digital asynchronous self-directed IPT training is feasible and acceptable, with preliminary evidence of efficacy for trainee competence and patient outcomes.
{"title":"Scaling up interpersonal psychotherapy training: A pilot randomized controlled trial of digital asynchronous self-directed vs. synchronous group workshop training","authors":"Paula Ravitz , Natalie Heeney , Andrea Lawson , Edward McAnanama , Clare Pain , Alex Kiss , Priya Watson , Jan Malat , Sophie Grigoriadis , Simone Vigod , Daisy R. Singla","doi":"10.1016/j.jadr.2024.100863","DOIUrl":"10.1016/j.jadr.2024.100863","url":null,"abstract":"<div><h3>Background</h3><div>Interpersonal Psychotherapy (IPT) is an effective depression treatment but limited numbers of trained providers result in less access than patients need. Asynchronous self-directed digital training may reduce this gap.</div></div><div><h3>Methods</h3><div>We developed digital IPT training and evaluated it in a pilot parallel randomized controlled trial. Psychiatry residents (N=25) in Toronto, Canada, were randomly assigned, 1:1, to an asynchronous self-directed digital course (intervention; n=13) or synchronous group training-as-usual workshop (control; n=12) and then delivered ∼12 clinically-supervised individual IPT sessions to depressed patients (N=26; 10≥PHQ9<20). The primary objective was to examine intervention feasibility and acceptability (retention, facilitators, barriers). We also examined resident competence (IPT knowledge, confidence, clinical skills, therapeutic alliances) and patient depressive outcomes (PHQ9).</div></div><div><h3>Results</h3><div>Resident retention in intervention (10/13; 76.9%) vs control (11/12; 91.7%) groups did not differ (<em>p</em>=.59). Qualitative semi-structured interviews with intervention residents (n=10) revealed that IPT's relational focus, video-recorded expert demonstrations (9/10; 90%), and case-based digital curriculum's user-friendliness (7/10; 70%) were facilitators. Half missed peer interactions in group workshops and found some interactive course elements disrupted learning. Both groups’ competence improved over time (F≥25.7, <em>p</em>≤.0001), with no significant between-arm differences in knowledge, confidence, skills, or therapeutic alliances (F≤1.07, <em>p</em>≥.31). Intervention and control patient groups improved from baseline (PHQ9=14.6 vs. 13.2; F=24.4, p=.0001), with no significant between-arm post-treatment depressive symptom differences (PHQ9=7.63 vs. 7.60, <em>t</em>=-0.01<em>, p</em>=.99).</div></div><div><h3>Limitations</h3><div>Small sample and provider type (psychiatry resident) limit generalizability.</div></div><div><h3>Conclusion</h3><div>Digital asynchronous self-directed IPT training is feasible and acceptable, with preliminary evidence of efficacy for trainee competence and patient outcomes.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100863"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.jadr.2024.100864
Egle M. Orlando , Giulia Buodo , Tania Moretta
Background
Psychological distress among college students is becoming a matter of significant clinical concern. Despite metacognitive beliefs and resting heart rate variability (HRV) are both associated with risk of mood disorders, whether in presence of maladaptive cognitive beliefs, resting HRV can be considered a protective factor for psychological distress in college students has yet to be investigated. Therefore, the present study aimed to test the relationship between maladaptive metacognitions (i.e., positive beliefs about worry; concerns about uncontrollability and danger; lack of cognitive confidence; beliefs about the need to control thoughts; cognitive self-consciousness) and psychological distress among college students, and the possible moderating effects of resting HRV.
Methods
Forty college students reporting negative history of neurological/psychiatric diseases and no use of drugs/substances of abuse were recruited at the University of Padova, Italy. Psychological distress and maladaptive metacognitions were assessed using the Depression Anxiety-Stress Scales 21 and the Metacognitions Questionnaire 30, respectively. Moreover, the electrocardiogram was recorded at rest for 5 minutes and HRV was computed as the root mean square of the successive differences in the interbeat intervals (rMSSD).
Limitations
Given the small sample size, this study should be used to design larger confirmatory studies.
Conclusions
Our findings suggest specific maladaptive metacognitions and high resting HRV as potential psychological vulnerability and psychophysiological protective factors of psychological distress among college students. From a clinical perspective, the present study suggests to implement prevention strategies targeting vagally-mediated HRV in order to reduce the risk of developing clinically significant psychological distress in college students.
{"title":"Psychological distress among college students: The moderating role of heart rate variability in the relationship with maladaptive metacognitions","authors":"Egle M. Orlando , Giulia Buodo , Tania Moretta","doi":"10.1016/j.jadr.2024.100864","DOIUrl":"10.1016/j.jadr.2024.100864","url":null,"abstract":"<div><h3>Background</h3><div>Psychological distress among college students is becoming a matter of significant clinical concern. Despite metacognitive beliefs and resting heart rate variability (HRV) are both associated with risk of mood disorders, whether in presence of maladaptive cognitive beliefs, resting HRV can be considered a protective factor for psychological distress in college students has yet to be investigated. Therefore, the present study aimed to test the relationship between maladaptive metacognitions (i.e., positive beliefs about worry; concerns about uncontrollability and danger; lack of cognitive confidence; beliefs about the need to control thoughts; cognitive self-consciousness) and psychological distress among college students, and the possible moderating effects of resting HRV.</div></div><div><h3>Methods</h3><div>Forty college students reporting negative history of neurological/psychiatric diseases and no use of drugs/substances of abuse were recruited at the University of Padova, Italy. Psychological distress and maladaptive metacognitions were assessed using the Depression Anxiety-Stress Scales 21 and the Metacognitions Questionnaire 30, respectively. Moreover, the electrocardiogram was recorded at rest for 5 minutes and HRV was computed as the root mean square of the successive differences in the interbeat intervals (rMSSD).</div></div><div><h3>Limitations</h3><div>Given the small sample size, this study should be used to design larger confirmatory studies.</div></div><div><h3>Conclusions</h3><div>Our findings suggest specific maladaptive metacognitions and high resting HRV as potential psychological vulnerability and psychophysiological protective factors of psychological distress among college students. From a clinical perspective, the present study suggests to implement prevention strategies targeting vagally-mediated HRV in order to reduce the risk of developing clinically significant psychological distress in college students.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100864"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this century, globally suicides have decreased, but decreasing trend was attenuated since the late 2010s, with these tendencies being more pronounced in adolescents. This study identified actual trends and risks of adolescent suicide in OECD countries during 1990–2019.
Methods
Fluctuation of adolescent (10–25 years) age-standardized death rate (ASDR), crude-mortality rate (CMR) and percentage of suicide per total-deaths (PTD) in 37 OECD countries obtained from “WHO Mortality Database” was analyzed by joinpoint regression. Fixed effects of gross domestic product per capita (GDPC) obtained from “OECD Data Explore” were determined using hierarchical linear model.
Results
Adolescent ASDR-suicide increased. Adolescent ASDR-suicide increased among males and females in Asia, Central/South America, and females in North America, unchanged in males and females in Oceania and males in North America, but decreased in males and females in Europe. PTD-suicide among adolescents in all regions consistently increased in 1990–2019 (with female predominance). Surprisingly, PTD-suicide in adolescents in Asia was approximately 50 % in the late 2010s. Fixed effects of males ASDR caused by traffic accidents and of females ASDR caused by violence positively related to ASDR-suicide of adolescent males and females, respectively.
Conclusions
Fluctuation adolescent males and females ASDR-suicide was not uniform across five regions among OECD. Contrary, adolescent PTD-suicide in five regions indicated increasing in all five regions; however, those in Asia and Oceania markedly larger compared to other regions. These results suggest that suicide prevention among adolescent health activities is lagging compared to other causes of death, especially in Asia and Oceania.
{"title":"Temporal fluctuations of adolescent suicides in OECD countries from 1990–2019","authors":"Ruri Okubo, Ryusuke Matsumoto, Eishi Motomura, Motohiro Okada","doi":"10.1016/j.jadr.2024.100857","DOIUrl":"10.1016/j.jadr.2024.100857","url":null,"abstract":"<div><h3>Background</h3><div>In this century, globally suicides have decreased, but decreasing trend was attenuated since the late 2010s, with these tendencies being more pronounced in adolescents. This study identified actual trends and risks of adolescent suicide in OECD countries during 1990–2019.</div></div><div><h3>Methods</h3><div>Fluctuation of adolescent (10–25 years) age-standardized death rate (ASDR), crude-mortality rate (CMR) and percentage of suicide per total-deaths (PTD) in 37 OECD countries obtained from “WHO Mortality Database” was analyzed by joinpoint regression. Fixed effects of gross domestic product per capita (GDPC) obtained from “OECD Data Explore” were determined using hierarchical linear model.</div></div><div><h3>Results</h3><div>Adolescent ASDR-suicide increased. Adolescent ASDR-suicide increased among males and females in Asia, Central/South America, and females in North America, unchanged in males and females in Oceania and males in North America, but decreased in males and females in Europe. PTD-suicide among adolescents in all regions consistently increased in 1990–2019 (with female predominance). Surprisingly, PTD-suicide in adolescents in Asia was approximately 50 % in the late 2010s. Fixed effects of males ASDR caused by traffic accidents and of females ASDR caused by violence positively related to ASDR-suicide of adolescent males and females, respectively.</div></div><div><h3>Conclusions</h3><div>Fluctuation adolescent males and females ASDR-suicide was not uniform across five regions among OECD. Contrary, adolescent PTD-suicide in five regions indicated increasing in all five regions; however, those in Asia and Oceania markedly larger compared to other regions. These results suggest that suicide prevention among adolescent health activities is lagging compared to other causes of death, especially in Asia and Oceania.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100857"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.jadr.2024.100858
Naohiro Yonemoto , Yoshitaka Kawashima
Background
Many studies have shown that Childhood, adolescent and young adult cancer (CAYAC) survivors have an increased risk of late physical and mental health effects. However, comprehensive data on the risks of suicidal behaviors in CAYAC survivors are still lacking. We investigated the evidence of suicidal behaviors in CAYAC survivors.
Methods
We performed a systematic review and meta-analysis. The literature search was conducted using MEDLINE, Embase, CINAHL, PsycINFO, the Cochrane Database, and reference lists from previous relevant reviews. We summarized the characteristics of eligible studies on suicidal behavior. We performed meta-analysis with random-effect model for available data of them and calculated pooled prevalences with 95 % confidence intervals (CI).
Results
We identified 1108 articles from the search and 22 articles from previous review. We identified 38 eligible studies. 26 cohort studies and 12 cross-sectional studies were compromised. The meta-analysis showed pooled prevalence of suicide was 0.152 % (95 % CI: 0.103–0.209), suicide attempt was 2.2 % (95 %CI; 1.9–2.6) and suicidal ideation was 9.2 % (95 %CI: 7.8–10.6). Some studies identified specific CAYAC survivors at risk of suicide as age, type of cancer and treatments.
Limitations
Outcome measures could not be identified in some studies in the meta-analysis.
Conclusions
The findings revealed prevalence of suicidal behaviors in CAYAC survivors. Greater awareness and monitoring are needed of these risks, and of issues that affect support to prevent suicidal behaviors in CAYAC survivors.
{"title":"The prevalence of suicidal behaviors in childhood, adolescent and young adults cancer survivors: A systematic review and meta-analysis","authors":"Naohiro Yonemoto , Yoshitaka Kawashima","doi":"10.1016/j.jadr.2024.100858","DOIUrl":"10.1016/j.jadr.2024.100858","url":null,"abstract":"<div><h3>Background</h3><div>Many studies have shown that Childhood, adolescent and young adult cancer (CAYAC) survivors have an increased risk of late physical and mental health effects. However, comprehensive data on the risks of suicidal behaviors in CAYAC survivors are still lacking. We investigated the evidence of suicidal behaviors in CAYAC survivors.</div></div><div><h3>Methods</h3><div>We performed a systematic review and meta-analysis. The literature search was conducted using MEDLINE, Embase, CINAHL, PsycINFO, the Cochrane Database, and reference lists from previous relevant reviews. We summarized the characteristics of eligible studies on suicidal behavior. We performed meta-analysis with random-effect model for available data of them and calculated pooled prevalences with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>We identified 1108 articles from the search and 22 articles from previous review. We identified 38 eligible studies. 26 cohort studies and 12 cross-sectional studies were compromised. The meta-analysis showed pooled prevalence of suicide was 0.152 % (95 % CI: 0.103–0.209), suicide attempt was 2.2 % (95 %CI; 1.9–2.6) and suicidal ideation was 9.2 % (95 %CI: 7.8–10.6). Some studies identified specific CAYAC survivors at risk of suicide as age, type of cancer and treatments.</div></div><div><h3>Limitations</h3><div>Outcome measures could not be identified in some studies in the meta-analysis.</div></div><div><h3>Conclusions</h3><div>The findings revealed prevalence of suicidal behaviors in CAYAC survivors. Greater awareness and monitoring are needed of these risks, and of issues that affect support to prevent suicidal behaviors in CAYAC survivors.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100858"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.jadr.2024.100860
Samantha Kenny , Rébecca Robillard , Mysa Saad , Tetyana Kendzerska , Lena Quilty , Elizaveta Solomonova , Elliott Lee , Alexander R. Daros , Roger Godbout , Marie-Hélène Pennestri
Background
Sleep disturbances are prevalent among individuals with eating disorders (EDs), yet limited research has explored the interplay between EDs and sleep during the COVID-19 pandemic. This study aimed to compare 1) self-reported sleep quality before the pandemic (retrospectively) among individuals with current EDs, remitted EDs, and controls (no psychiatric history); and 2) sleep quality differences among these groups from before to during the pandemic.
Methods
Participants (N = 1033) completed the Pittsburgh Sleep Quality Index and reported anxiety and depression symptoms for the month before the pandemic onset (retrospectively) and during the pandemic. One-way ANCOVAs compared sleep quality among groups before the pandemic, adjusting for anxiety and depression symptoms and demographics. Repeated measures ANCOVAs assessed sleep quality differences between before and during the pandemic, controlling for the same covariates.
Results
Pre-pandemic, individuals with current EDs reported the highest sleep disturbance levels, followed by those with remitted EDs and controls (F (2, 955) = 11.01, p < 0.001). During the pandemic, sleep disturbance worsened across all groups, with individuals in current and remitted ED groups experiencing a more significant deterioration than controls, even when accounting for anxiety and depression symptoms (p < 0.05).
Limitations
The cross-sectional design and retrospective self-reports of sleep quality.
Conclusions
Individuals with current and remitted EDs seemed to be vulnerable to sleep disruptions during the pandemic. Sleep disruptions may persist during ED remission. Awareness of these dynamics can enhance mental health practitioners’ attention to sleep disruptions in adults with current or remitted EDs.
{"title":"The association between sleep and eating disorders in Canada before and during the first wave of the COVID-19 pandemic","authors":"Samantha Kenny , Rébecca Robillard , Mysa Saad , Tetyana Kendzerska , Lena Quilty , Elizaveta Solomonova , Elliott Lee , Alexander R. Daros , Roger Godbout , Marie-Hélène Pennestri","doi":"10.1016/j.jadr.2024.100860","DOIUrl":"10.1016/j.jadr.2024.100860","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are prevalent among individuals with eating disorders (EDs), yet limited research has explored the interplay between EDs and sleep during the COVID-19 pandemic. This study aimed to compare 1) self-reported sleep quality before the pandemic (retrospectively) among individuals with current EDs, remitted EDs, and controls (no psychiatric history); and 2) sleep quality differences among these groups from before to during the pandemic.</div></div><div><h3>Methods</h3><div>Participants (<em>N</em> = 1033) completed the Pittsburgh Sleep Quality Index and reported anxiety and depression symptoms for the month before the pandemic onset (retrospectively) and during the pandemic. One-way ANCOVAs compared sleep quality among groups before the pandemic, adjusting for anxiety and depression symptoms and demographics. Repeated measures ANCOVAs assessed sleep quality differences between before and during the pandemic, controlling for the same covariates.</div></div><div><h3>Results</h3><div>Pre-pandemic, individuals with current EDs reported the highest sleep disturbance levels, followed by those with remitted EDs and controls (<em>F</em> (2, 955) = 11.01, <em>p</em> < 0.001). During the pandemic, sleep disturbance worsened across all groups, with individuals in current and remitted ED groups experiencing a more significant deterioration than controls, even when accounting for anxiety and depression symptoms (<em>p</em> < 0.05).</div></div><div><h3>Limitations</h3><div>The cross-sectional design and retrospective self-reports of sleep quality.</div></div><div><h3>Conclusions</h3><div>Individuals with current and remitted EDs seemed to be vulnerable to sleep disruptions during the pandemic. Sleep disruptions may persist during ED remission. Awareness of these dynamics can enhance mental health practitioners’ attention to sleep disruptions in adults with current or remitted EDs.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"19 ","pages":"Article 100860"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}