Journal of Affective Disorders Reports最新文献

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The efficacy of the unified protocol for emotional disorders in children and adolescents: A systematic review and meta-analysis 儿童和青少年情绪障碍统一方案的疗效：系统回顾和荟萃分析

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-09-04 DOI: 10.1016/j.jadr.2025.100970

Malte Schäpermeier , Anna-Lena Jesussek , Jasmin Kirchherr , Maximilian Monninger , Anja C. Feneberg , Tanja Hechler

Transdiagnostic treatments such as the Unified Protocol for Emotional Disorders in Children and Adolescents (UP-C/A; Ehrenreich-May, J., Kennedy, S.M., Sherman, J.A., Bilek, E.L., Buzzella, B.A., Bennett, S.M., Barlow, D.H., 2017a) aim to target shared mechanisms across mental disorders and to achieve positive treatment outcomes. Several studies investigated the UP-C/A with promising results regarding the improvement of internalizing symptoms. However, there is currently no meta-analysis investigating the efficacy across the existing studies. In this preregistered systematic review and meta-analysis (PROSPERO CRD 42023474832), we analyzed whether the UP-C/A is effective in reducing internalizing symptoms (primary outcome) and secondary outcomes such as emotion regulation in comparison to control treatments where applicable, and from pre- to post-treatment and follow-up. We also examined whether moderators (i.e., sample and treatment characteristics) predicted the effects of the UP-C/A. We included 21 studies (9 RCTs, 11 uncontrolled studies, 1 single-case experimental study) with a total of N = 994 participants. For internalizing symptoms, we found moderate to large controlled effects post-treatment (g = 0.58, p = .014) and at follow-up (g = 0.79, p = .003). Uncontrolled effects were large in both cases. We also found moderate to large effects for secondary outcomes (i.e., emotion regulation, global severity of psychopathology, global functioning). Treatment format did not impact the efficacy. Overall, our findings suggest that the UP-C/A is effective in treating internalizing symptoms in children and adolescents that can be offered in different formats. However, more research is needed to draw robust conclusions regarding specific treatment mechanisms underlying these effects.

跨诊断治疗，如儿童和青少年情绪障碍统一协议（UP-C/A; Ehrenreich-May， J., Kennedy, s.m., Sherman, j.a., Bilek, e.l., Buzzella, b.a., Bennett, s.m., Barlow, d.h., 2017a）旨在针对精神障碍的共同机制并获得积极的治疗结果。几项研究调查了UP-C/A，在改善内化症状方面取得了令人鼓舞的结果。然而，目前还没有对现有研究的疗效进行荟萃分析。在这项预登记的系统评价和荟萃分析（PROSPERO CRD 42023474832）中，我们分析了UP-C/A与适用的对照治疗相比，在减少内化症状（主要结局）和次要结局（如情绪调节）方面是否有效，以及从治疗前到治疗后和随访。我们还检查了调节因子（即样本和处理特征）是否预测UP-C/A的效果。我们纳入了21项研究（9项随机对照试验，11项非对照研究，1项单例实验研究），共N = 994名受试者。对于内化症状，我们发现治疗后（g = 0.58, p = 0.014）和随访时（g = 0.79, p = 0.003）的控制效果中等至较大。在这两种情况下，不受控制的影响都很大。我们还发现次要结果（即情绪调节，精神病理的整体严重程度，整体功能）有中等到较大的影响。治疗方式对疗效无影响。总的来说，我们的研究结果表明，UP-C/A在治疗儿童和青少年的内化症状方面是有效的，可以以不同的形式提供。然而，需要更多的研究来得出关于这些影响的具体治疗机制的有力结论。

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引用次数: 0

A prospective cohort study on changes in psychosocial distress and preterm birth among pregnant Pakistani women 巴基斯坦孕妇社会心理困扰与早产变化的前瞻性队列研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-08-19 DOI: 10.1016/j.jadr.2025.100964

Salima Sulaiman , Aliyah Dosani , Ilona S. Yim , Sharifa Lalani , Ntonghanwah Forcheh , Shahirose Sadrudin Premji , Maternal-infant Global Health Team (MiGHT)—Collaborators in Research

Changes in mental health during pregnancy may better predict preterm birth (PTB) as assessment at one time point are inconsistently associated with this outcome. Our prospective cohort study of 1225 pregnant Pakistani women determined whether (a) changes in psychosocial distress (i.e., pregnancy-related anxiety, state anxiety, depressive symptoms) between 10 and 19 and 22 to 29 weeks’ gestational age influenced the risk of PTB; and (b) social determinants of health and chronic stress influenced this relationship. The individual effect of changes in (a) pregnancy-related anxiety on PTB was significant only among women with low social support from family (OR = 0.85, 95 % CI 0.74–0.97, p = 0.017); and (b) depressive symptoms on PTB were significantly modified by education (p = 0.011), number of previous children (p = 0.028) and life-time interpersonal trauma (p = 0.073). The average aggregate change score was associated with PTB among women with low family support (OR = 0.79, 95 % CI 0.67–0.93, p = 0.005), after adjusting for confounders. The collective effect, assessed using multiple logistic regression, was not significant. Chronic stress did not alter any findings. An intersectional approach will enable exploration of the disparate burden of psychosocial distress during pregnancy on PTB.

怀孕期间心理健康的变化可能更好地预测早产（PTB），因为在一个时间点的评估与这一结果的相关性不一致。我们对1225名巴基斯坦孕妇进行了前瞻性队列研究，以确定(a)胎龄在10 - 19周和22 - 29周之间的心理社会困扰（即妊娠相关焦虑、状态焦虑、抑郁症状）的变化是否影响PTB的风险；(b)健康和慢性压力的社会决定因素影响了这种关系。(a)妊娠相关焦虑变化对肺结核的个体影响仅在家庭社会支持较低的妇女中显著（OR = 0.85, 95% CI 0.74-0.97, p = 0.017）；(b)受教育程度（p = 0.011）、既往子女数量（p = 0.028）和终生人际创伤（p = 0.073）显著改善肺结核患者的抑郁症状。在调整混杂因素后，家庭支持度低的妇女的平均总变化得分与PTB相关（OR = 0.79, 95% CI 0.67-0.93, p = 0.005）。使用多元逻辑回归评估的集体效应不显著。慢性压力没有改变任何发现。交叉方法将使探索不同负担的心理社会困扰怀孕期间对肺结核。

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引用次数: 0

Erratum regarding missing Statements in previously published articles 关于先前发表的文章中缺失陈述的勘误

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-08-05 DOI: 10.1016/j.jadr.2025.100956

引用次数: 0

Erratum regarding missing Statements in previously published articles 关于先前发表的文章中缺失陈述的勘误

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-31 DOI: 10.1016/j.jadr.2025.100957

引用次数: 0

Erratum regarding previously published articles 关于以前发表的文章的勘误

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-14 DOI: 10.1016/j.jadr.2025.100942

引用次数: 0

The impact of repetitive transcranial magnetic stimulation on anxiety and cognitive function in generalized anxiety disorder: a comprehensive review 反复经颅磁刺激对广泛性焦虑障碍患者焦虑和认知功能的影响：综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100945

Xuan Zhang , Xiaodong Chen , Leijun Li, Xiuhua Wu, Jiaxin Huang, Xin Qin, Qinsheng Chen, Hongyun Zhou, Jiong Tao, Jihui Wang

Anxiety disorder is one of the major health burdens in the world, and most of the patients have significantly impaired social function, which seriously affects their quality of life. Currently, conventional treatment methods include medication and psychotherapy. However, due to the limitations of these treatments and the lack of response in some patients, finding effective alternative treatment options has become urgent. Repetitive transcranial magnetic stimulation (rTMS), a relatively non-invasive and safe physical therapy, has been increasingly recommended for anxiety disorders in recent years. Nevertheless, the therapeutic effects, optimal stimulation sites, and stimulation parameters remain unclear. This article aims to provide a systematic review of the current state of rTMS treatment for generalized anxiety disorder(GAD), offering new perspectives for identifying more effective and personalised adjunctive options.

焦虑障碍是世界上主要的健康负担之一，大多数患者的社会功能明显受损，严重影响其生活质量。目前，传统的治疗方法包括药物治疗和心理治疗。然而，由于这些治疗的局限性和一些患者缺乏反应，寻找有效的替代治疗方案已成为当务之急。重复性经颅磁刺激（rTMS）是一种相对无创、安全的物理治疗方法，近年来越来越多地被推荐用于治疗焦虑症。然而，治疗效果、最佳刺激部位和刺激参数仍不清楚。本文旨在对rTMS治疗广泛性焦虑障碍（GAD）的现状进行系统回顾，为确定更有效和个性化的辅助选择提供新的视角。

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引用次数: 0

Burnout in the general population: Role of anxiety, depression and traumatic events 普通人群的职业倦怠：焦虑、抑郁和创伤性事件的作用

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100941

Lucia Romo , Clément Duret , Laurent Cruchet , Stéphanie Nann , Samantha Tessier , Oulmann Zerhouni

Objective

This study aims to examine the predictors of work exhaustion in the general population, with a particular focus on the roles of burnout, anxiety, depression, and trauma-related symptoms.

Methods

A cross-sectional survey was conducted among a sample from the French general population. The survey included measures of burnout using the Copenhagen Burnout Inventory (CBI), anxiety (GAD-7), depression (PHQ-9), and trauma-related symptoms (International Trauma Questionnaire [ITQ]). Correlation and Regression analyses were performed to identify significant predictors of work exhaustion

Results

The analysis revealed that personal burnout (CBI) were significant positive predictors of work exhaustion. Older individuals and men reported higher levels of work exhaustion. However, anxiety, depression, and trauma-related symptoms did not emerge as significant predictors.

Conclusion

The findings underscore the critical role of specific dimensions of burnout, particularly personal burnout, in predicting work exhaustion. These results suggest that targeted interventions addressing these aspects of burnout may be crucial in reducing work-related stress and improving employee well-being. The study also highlights the need for further research on the indirect effects of trauma on work exhaustion in the general population.

目的本研究旨在探讨普通人群工作疲劳的预测因素，特别关注倦怠、焦虑、抑郁和创伤相关症状的作用。方法对法国普通人群进行横断面调查。该调查包括使用哥本哈根倦怠量表（CBI）、焦虑（GAD-7）、抑郁（PHQ-9）和创伤相关症状（国际创伤问卷[ITQ]）进行倦怠测量。结果个人倦怠（personal burnout， CBI）是工作倦怠的显著正向预测因子。老年人和男性报告的工作疲劳程度更高。然而，焦虑、抑郁和创伤相关症状并没有成为显著的预测因素。结论研究结果强调了职业倦怠的特定维度，尤其是个人职业倦怠在预测工作倦怠中的重要作用。这些结果表明，针对这些方面的倦怠进行有针对性的干预可能是减少工作压力和提高员工幸福感的关键。该研究还强调，需要进一步研究创伤对普通人群工作疲劳的间接影响。

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引用次数: 0

Sociodemographic predictors of depression among economically vulnerable mothers in urban Uruguay 乌拉圭城市经济弱势母亲抑郁的社会人口学预测因素

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100978

Anahita Kumar , Juanita Bloomfield , Ana Balsa , Hang Do (Heather) , Alejandro Cid , Guilherme Lichand , Sharon Wolf

Background

Depression is a leading cause of disability worldwide, affecting women twice as much as men. In Latin America, rates are double the global average. Uruguay, despite investing in mental health, has the continent’s highest and still-rising suicide rate.

Methods

We examine predictors of depression among a sample of economically vulnerable mothers in Uruguay (N = 467). Depression was measured using the Center for Epidemiologic Studies Depression Scale (CES-D). Sociodemographic predictors were added in blocks using hierarchical regression with robust standard errors.

Results

On average, survey respondents were 29 years of age (SD = 6.65), with children aged 24 months (SD = 5.97). The average CES-D score was 6.9 (range 0–46), with 12 % of respondents at risk (CES-D ≥ 16). Mothers who had completed middle or secondary school had lower levels. In contrast, experiencing a negative economic shock in the past year and receiving government assistance were associated with higher depression. Mothers receiving government assistance were 8 percentage points more likely to be at risk of depression, suggesting a subgroup prevalence of ∼ 20 %- a figure that aligns closely with prior estimates in similar populations. Among subgroups, mothers (not receiving assistance) who worked part-time had higher CES-D scores than those working full-time.

Limitations

We rely on self-reported, cross-sectional data.

Conclusions

Indicators of economic strain predict increased depression levels among mothers in Uruguay. Higher education and full-time employment were protective factors. The elevated risk among mothers receiving government assistance highlights the need for integrated mental health and social support interventions.

抑郁症是世界范围内致残的主要原因，对女性的影响是男性的两倍。在拉丁美洲，这一比率是全球平均水平的两倍。尽管乌拉圭在心理健康方面进行了投资，但该国的自杀率仍是非洲大陆最高的，而且仍在上升。方法研究了乌拉圭经济弱势母亲的抑郁预测因素（N = 467）。使用流行病学研究中心抑郁量表（CES-D）测量抑郁症。使用具有稳健标准误差的分层回归将社会人口学预测因子分组添加。结果调查对象平均年龄为29岁（SD = 6.65），儿童年龄为24月龄（SD = 5.97）。平均CES-D评分为6.9（范围0-46），12%的受访者存在风险（CES-D≥16）。完成初中或中学教育的母亲的水平较低。相比之下，在过去一年经历负面经济冲击和接受政府援助的人更容易抑郁。接受政府援助的母亲患抑郁症的可能性高出8个百分点，这表明亚组患病率为20%，这一数字与之前对类似人群的估计非常吻合。在亚组中，兼职母亲（不接受援助）的CES-D分数高于全职母亲。局限性：我们依赖于自我报告的横断面数据。结论经济压力指标预示着乌拉圭母亲抑郁程度的增加。高等教育和全职工作是保护因素。接受政府援助的母亲风险增加，突出表明需要采取综合心理健康和社会支助干预措施。

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引用次数: 0

Relationship between impulsivity and vocal emotion recognition following cerebellar stroke 小脑卒中后冲动与声音情绪识别的关系

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100969

Annie Sautebin , Ioana Medeleine Constantin , Philippe Voruz , Marine Thomasson , Didier Grandjean , Frédéric Assal , Julie Anne Péron

Background

Previous research has established a link between impulsivity and emotion recognition across various pathologies, highlighting the cerebellum's role in both impulsive behavior and vocal emotion processing. However, the relationship between these factors in patients with chronic cerebellar stroke remains unexplored.

Aim

This study aimed to investigate whether impulsivity predicts the auditory recognition of emotions previously identified as deficient—specifically anger, sadness, and neutral—in cerebellar stroke patients.

Methods

We conducted LASSO regressions using data extracted from the dataset of the CEREBEMO project, which assessed emotional prosody recognition through a validated task. The analysis included the French-validated Urgency-Premeditation-Perseverance-Sensation Seeking (UPPS) impulsivity scale, with a sample of 26 patients.

Results

Results revealed significant effects of sensation seeking, urgency and lack of premeditation scores on the emotional prosody recognition of anger and sadness stimuli. Significant effects of gender, age, lesion side and time since the stroke on emotional prosody performances were also found.

Conclusions

Impulsivity can predict the ability to identify vocal emotions among patients in the chronic phase following cerebellar stroke. These insights suggest that addressing impulsivity may enhance emotional recognition capabilities and, consequently, improve social functioning in this population.

先前的研究已经建立了冲动和情绪识别之间的联系，强调了小脑在冲动行为和声音情绪处理中的作用。然而，这些因素在慢性小脑卒中患者中的关系仍未被探索。目的本研究旨在探讨冲动性是否能预测小脑卒中患者对先前被认为有缺陷的情绪（特别是愤怒、悲伤和中性）的听觉识别。方法使用从CEREBEMO项目数据集提取的数据进行LASSO回归，通过验证任务评估情绪韵律识别。分析包括法国认可的紧急-预谋-坚持-感觉寻求（UPPS）冲动量表，样本为26例患者。结果发现感觉寻求、紧迫感和缺乏预谋得分对愤怒和悲伤刺激的情绪韵律识别有显著影响。性别、年龄、发病部位及发病时间对情绪韵律表现均有显著影响。结论脉冲性可以预测小脑卒中后慢性期患者的声音情绪识别能力。这些见解表明，处理冲动可能会提高情绪识别能力，从而改善这一人群的社会功能。

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引用次数: 0

Decreased PON1 activity as a biological marker for depressive disorders: a narrative review PON1活性降低作为抑郁症的生物学标志物：一项叙述性综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 DOI: 10.1016/j.jadr.2025.100947

Oleg A. Levada, Oleksandra S. Troian

Background

This study conducts a narrative review to summarize evidence regarding changes in serum/plasma paraoxonase 1 (PON1) activity in patients with major depressive disorder (MDD) or other depressive disorders and assess their possible marker value.

Methods

We searched the PubMed database for articles published from inception to December 2024 on the relationship between depression and PON1 activities/concentrations.

Results

Seventeen articles from 2006 to 2022 were included in the final analysis. 70 % of the studies demonstrated a decline in PON1 (predominantly arylesterase activity) during MDD episodes and depressive disorders induced by methamphetamine and Parkinson`s disease. Lower PON1 paraoxonase activity was associated with the number of previous depressive episodes (DE), worse outcomes, and higher DE severity. Two studies showed an increase in PON1 activity after antidepressant treatment. The decline of PON1 has a genetic predisposition. QQ and QR genotypes of PON1 increased the odds of depression. MDD patients with QQ genotype (in contrast to QR and RR) showed lowered PON1 activity.

Conclusion

There is a decline in arylesterase/paraoxonase activity and PON1 concentrations in MDD and secondary depressive disorders. The decline is also associated with the severity and number of DE. Antidepressant treatment might increase PON1 activity. Genetic predisposition and epigenetic mechanisms that decrease PON1 activity might disrupt antioxidative mechanisms and lipid metabolism, which could be a part of complex pathogenesis and/or lead to comorbid somatic MDD pathology related to accelerated aging. PON1 activity and concentrations decline might be a marker for MDD and other DE, whereas PON1 increase – for treatment efficacy.

本研究对重度抑郁症（MDD）或其他抑郁症患者血清/血浆对氧磷酶1 （PON1）活性变化的证据进行综述，并评估其可能的标志物价值。方法检索PubMed数据库中自成立至2024年12月发表的有关抑郁症与PON1活性/浓度关系的文章。结果2006 - 2022年共纳入17篇文章。70%的研究表明，在甲基苯丙胺和帕金森病引起的重度抑郁症发作和抑郁症期间，PON1（主要是芳基酯酶活性）下降。较低的PON1对氧磷酶活性与既往抑郁发作（DE）次数、较差的结局和较高的DE严重程度相关。两项研究显示抗抑郁治疗后PON1活性增加。PON1的下降有遗传易感性。PON1的QQ和QR基因型增加抑郁的几率。QQ基因型MDD患者（与QR和RR相比）PON1活性降低。结论重度抑郁症和继发性抑郁症患者芳香酯酶/对氧磷酶活性和PON1浓度均有下降。这种下降也与DE的严重程度和次数有关。抗抑郁治疗可能会增加PON1活性。遗传易感性和表观遗传机制降低PON1活性可能会破坏抗氧化机制和脂质代谢，这可能是复杂发病机制的一部分和/或导致与加速衰老相关的躯体MDD共病病理。PON1活性和浓度的下降可能是MDD和其他DE的标志，而PON1的增加可能是治疗效果的标志。

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