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Arsenic in the Soil-Plant-Human Continuum in Regions of Asia: Exposure and Risk Assessment 亚洲地区土壤-植物-人类连续体中的砷:暴露和风险评估
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-08-31 DOI: 10.1007/s40726-023-00279-2
D. Golui, Md Basit Raza, Arkaprava Roy, Jajati Mandal, Ankit Kumar Sahu, P. Ray, S. Datta, Mohammad Mahmudur Rahman, A. Bezbaruah
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引用次数: 1
Arsenic and Human Health: New Molecular Mechanisms For Arsenic-Induced Cancers 砷与人类健康:砷诱发癌症的新分子机制
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-08-23 DOI: 10.1007/s40726-023-00278-3
Alexandra N. Nail, Manting Xu, J. C. Bastick, Deep P. Patel, Max N. Rogers, J. States
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引用次数: 0
Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review 不同途径人体微塑料暴露及其对靶器官的潜在健康风险综述
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-08-17 DOI: 10.1007/s40726-023-00273-8
Ziye Yang, Meixue Wang, Zhihong Feng, Ziqi Wang, Mingxia Lv, Jinghao Chang, Liqun Chen, Can Wang

Purpose of Review

Microplastics in the environment enter the human body through diet, drinking water, and air inhalation. The widespread detection of microplastics in several human tissues was conducted. However, limited knowledge exists on the number of microplastics that can be ingested by humans and the potential adverse effects on various organs. To address these issues, we reviewed the types and abundance of microplastics through different pathways and summarized the average annual intake in humans.

Recent Findings

An adult can ingest about (4.88–5.77) × 105 microplastics/year through the dietary route [including salt (5.00–7.00) × 103, fish (0.50–1.20)×104, fruits (4.48–4.62) × 105, and vegetables (2.96–9.55)×104]. The amount of microplastics ingested via drinking water route was approximately (0.22–1.2)×106 microplastics/year. Inhalation of microplastics via atmospheric environment was nearly (0.21–2.51) × 106 microplastics/year [including indoor (0.16–2.30) × 106 and outdoor (0.46–2.10)×105].

Summary

In conclusion, we found that the human body ingests microplastics most through inhalation, followed by drinking water and diet. We also summarized the types and abundance of microplastics that were enriched in different organs after microplastics entered the human body. Microplastics entering the body would cross the barrier into the target effector organs and cause adverse health effects, mainly including induction of intracellular oxidative stress, genotoxicity, reproductive toxicity, and inflammatory responses. In conclusion, exposure to microplastics can cause many adverse effects on the health of the organism. Thus, an increased awareness of the crisis, urgent discussion, and practical actions are needed to mitigate microplastics contaminants in the environment.

Graphical Abstract

环境中的微塑料通过饮食、饮用水和吸入空气进入人体。在几种人体组织中广泛检测到微塑料。然而,关于人类可以摄入的微塑料数量以及对各种器官的潜在不利影响的知识有限。为了解决这些问题,我们回顾了通过不同途径摄入微塑料的类型和丰度,并总结了人类年平均摄入量。3名成人通过膳食途径(包括盐(5.00-7.00)× 103,鱼(0.50-1.20)×104,水果(4.48-4.62)× 105,蔬菜(2.96-9.55)×104)摄入微塑料约(4.88-5.77)× 105 /年。通过饮用水途径摄入的微塑料量约为(0.22-1.2)×106微塑料/年。大气环境对微塑料的吸入量接近(0.21-2.51)× 106微塑料/年[包括室内(0.16-2.30)× 106微塑料/年和室外(0.46-2.10)×105]。综上所述,我们发现人体通过吸入摄入微塑料最多,其次是饮用水和饮食。我们还总结了微塑料进入人体后在不同器官中富集的类型和丰度。进入体内的微塑料会越过屏障进入目标效应器官,对健康造成不良影响,主要包括诱导细胞内氧化应激、遗传毒性、生殖毒性和炎症反应。总之,接触微塑料会对生物体的健康造成许多不利影响。因此,需要提高对危机的认识,紧急讨论和实际行动,以减轻环境中的微塑料污染物。图形抽象
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引用次数: 0
Date Palm Biochar and Date Palm Activated Carbon as Green Adsorbent—Synthesis and Application 枣树生物炭和枣树活性炭作为绿色吸附剂的合成与应用
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-08-16 DOI: 10.1007/s40726-023-00275-6
Mona Al Malki, Abu Zahrim Yaser, Mohd. Amir Asyraf Mohd. Hamzah, Muhammad Abbas Ahmad Zaini, Nurzila Ab. Latif, Siti Halimah Hasmoni, Zainul Akmar Zakaria

Purpose of Review

The issue of improper wastewater treatment disposal from various sources is a global issue that needs immediate tackling. The increase in global population, sustainable agricultural practice, and heightened energy production demand has increased the need for clean water supply to multiple fold. It is therefore a continuous challenge to develop technique that could treat the wastewater as efficient but at a lower production cost with sustainable supply of raw materials.

Recent Findings

Apart from the extensively studied forest and forest industry residues, date palm (Phoenix dactylifera L.) offers an exciting future as a sustainable raw material to produce biochar and/or activated carbon that can be employed as a green adsorbent in wastewater treatment application. Various carbonization and activation techniques have been reported for date palm waste biomass as well as its potential applications. Nevertheless, there are very few literatures available on the benchmarking of each date palm biomass type for its characteristics, production methods, and pollutant removal capabilities.

Summary

This review highlights some of the carbonization and activation methods available to manufacture biochar and activated carbon from date palm followed by some examples of its applications. Even though date palm biomass can be found in huge volume in date palm-growing area such as the Arab region, few reports are available on its utilization in actual industrial processes, pollutant removal from water system, for example. This review offers new insight into the conversion techniques of date palm biomass, its characterization, and evaluation of its pollutant removal capacity, among others. This work is envisaged to shed insight into a comprehensive outlook on the promising applications of date palm biomass to produce potent green adsorbents as well as its potential applications in other economic sectors.

各种来源的废水处理处置不当的问题是一个需要立即解决的全球性问题。全球人口的增加、可持续农业实践和能源生产需求的增加使对清洁水供应的需求增加了数倍。因此,开发一种既能高效处理废水,又能以较低的生产成本和可持续的原材料供应的技术是一个持续的挑战。最近的发现除了被广泛研究的森林和森林工业残留物外,枣椰树(Phoenix dactylifera L.)作为一种可持续的原料,生产生物炭和/或活性炭,可以作为一种绿色吸附剂应用于废水处理中,具有令人兴奋的前景。各种各样的炭化和活化技术对枣椰树废生物质及其潜在的应用进行了报道。然而,对每种枣椰树生物量类型的特征、生产方法和污染物去除能力进行基准测试的文献很少。综述了从枣椰树中制备生物炭和活性炭的炭化和活化方法,并列举了其应用实例。尽管在阿拉伯地区等椰枣树种植区可以发现大量的椰枣树生物量,但关于在实际工业过程中利用椰枣树生物量的报告很少,例如从水系统中去除污染物。本文综述了枣椰树生物质转化技术、表征及其污染物去除能力评价等方面的研究进展。预计这项工作将深入了解椰枣生物质在生产强效绿色吸附剂及其在其他经济部门的潜在应用方面的前景。
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引用次数: 0
Crosslinked Cyclodextrin as Potent Composite For Removal of Wastewater Pollutants 交联环糊精作为去除废水污染物的有效复合材料
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-08-16 DOI: 10.1007/s40726-023-00277-4
Nurul Elia Aqila Abu Rahim, N. I. Wan Azelee, Siti Fatimah Zaharah Mohd Fuzi, N. Masngut, Zainul Akmar Zakaria, A. Zulkharnain, R. Illias, Nor Hasmaliana Abdul Manas
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引用次数: 1
Sealants and Other Management Strategies for PFAS-Contaminated Concrete and Asphalt PFAS污染混凝土和沥青的密封剂和其他管理策略
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-08-05 DOI: 10.1007/s40726-023-00276-5
G. Douglas, J. Vanderzalm, J. Kirby, Mike Williams, T. Bastow, M. Bauer, K. Bowles, Darren Skuse, R. Kookana, G. Davis
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引用次数: 0
Heavy Metals in Indoor Dust in China: Occurrence, Source, and Health Risk 中国室内粉尘中重金属的发生、来源及健康风险
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-07-08 DOI: 10.1007/s40726-023-00274-7
Jie Sun, Jinze Wang, Yaoxing Feng, N. Lin, Zhenglu Wang, Yuanchen Chen, Peng Zhang, Min Wu, W. Du, Bo Pan
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引用次数: 0
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies PFAS暴露与人类代谢组:流行病学研究的系统综述
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-06-29 DOI: 10.1007/s40726-023-00269-4
Sandra India-Aldana, Meizhen Yao, Vishal Midya, Elena Colicino, Leda Chatzi, Jaime Chu, Chris Gennings, Dean P. Jones, Ruth J. F. Loos, Veronica W. Setiawan, Mathew Ryan Smith, Ryan W. Walker, Dinesh Barupal, Douglas I. Walker, Damaskini Valvi

Purpose of Review

There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines.

Recent Findings

We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics.

Summary

Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.

综述目的通过对人体代谢组的研究,人们对了解暴露于全氟烷基和多氟烷基物质(PFAS)对健康的影响越来越感兴趣。在这篇系统综述中,我们旨在确定PFAS和代谢组学特征之间的一致发现。根据PRISMA指南,我们对两个数据库(EMBASE和PubMed)从建立到2022年7月19日期间由两位作者独立审查的特定关键词进行了搜索匹配。最近的发现我们总共确定了28项符合条件的观察性研究,评估了31种不同的PFAS暴露与人类代谢组学之间的关系。最常见的暴露评估是遗留的长链PFAS。总体样本量从40人到1105人不等,他们处于生命的不同阶段。共有19项研究使用了非靶向代谢组学方法,7项研究使用了靶向方法,2项研究两者都使用。大多数研究是横断面的(n = 25),包括四项在代谢组学之前测量PFAS的前瞻性分析。研究中最常见的关联是观察到PFAS与氨基酸、脂肪酸、甘油磷脂、甘油脂、磷脂、胆汁酸、神经酰胺、嘌呤和酰基肉碱之间的关联。相应的代谢途径也发生了变化,包括脂质、氨基酸、碳水化合物、核苷酸、能量代谢、聚糖的生物合成和代谢以及辅助因子和维生素的代谢。我们在研究中发现了一致的证据,表明pfas诱导脂质和氨基酸代谢物的改变,这可能涉及能量和细胞膜破坏。
{"title":"PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies","authors":"Sandra India-Aldana,&nbsp;Meizhen Yao,&nbsp;Vishal Midya,&nbsp;Elena Colicino,&nbsp;Leda Chatzi,&nbsp;Jaime Chu,&nbsp;Chris Gennings,&nbsp;Dean P. Jones,&nbsp;Ruth J. F. Loos,&nbsp;Veronica W. Setiawan,&nbsp;Mathew Ryan Smith,&nbsp;Ryan W. Walker,&nbsp;Dinesh Barupal,&nbsp;Douglas I. Walker,&nbsp;Damaskini Valvi","doi":"10.1007/s40726-023-00269-4","DOIUrl":"10.1007/s40726-023-00269-4","url":null,"abstract":"<div><h3>Purpose of Review</h3><p>There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines.</p><h3>Recent Findings</h3><p>We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (<i>n</i> = 25), including four with prospective analyses of PFAS measured prior to metabolomics.</p><h3>Summary</h3><p>Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.</p></div>","PeriodicalId":528,"journal":{"name":"Current Pollution Reports","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40726-023-00269-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6713807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Triclosan on the Development of Antimicrobial Resistance in the Environment: A Review 三氯生对环境中细菌耐药性的影响
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-06-26 DOI: 10.1007/s40726-023-00270-x
Chunzhen Wang, Shihai Liu, Haodi Feng, Holly Barrett, Hui Peng, S. H. P. Parakrama Karunaratne, Yu Zhang, Min Yang

Purpose of Review

Triclosan (TCS), a widely used broad-spectrum antimicrobial agent, enters to wastewater treatment plants (WWTPs) and the environment ultimately after its usage. Notably, the use of TCS has surged during the outbreak of COVID-19, leading to the environment under increasing TCS pollution pressure. Even environmentally relevant concentrations of TCS can promote the development of antimicrobial resistance (AMR), which is a major public health concern. The purpose of this study is to provide a basis for the management and risk assessment of TCS by providing a holistic review of the impact of TCS on AMR in the environment.

Recent Findings

Bacterial resistance to TCS mainly takes place through modification or replacement of the FabI enzyme, which is the main target of TCS in bacteria. Currently, multiple FabI mutants and isoenzymes have been identified in the environment giving bacterial resistance to TCS. In addition, mechanisms by which TCS promotes bacterial development of resistance to other antimicrobials have been studied in laboratory experiments and environmental settings, such as anaerobic digester. TCS will promote the development of AMR in the environment with the possibility of adverse risks to public health.

Summary

This review systematically summarizes the mechanisms of bacterial resistance to antimicrobials driven by TCS and highlights the effects of TCS in promoting the horizontal transfer and enrichment of antibiotic resistance genes (ARGs). Suggestions for overcoming the limitations of laboratory-scale studies and further improving the risk assessment of TCS in the environment are proposed.

三氯生(TCS)是一种广泛应用的广谱抗菌剂,其使用后最终进入污水处理厂和环境。值得注意的是,在新冠肺炎疫情期间,TCS的使用量激增,导致环境面临越来越大的TCS污染压力。即使是与环境相关的TCS浓度也会促进抗菌素耐药性(AMR)的发展,这是一个主要的公共卫生问题。本研究的目的是通过全面审查TCS对环境中抗菌素耐药性的影响,为TCS的管理和风险评估提供基础。细菌对TCS的耐药主要是通过修饰或替换FabI酶来实现的,FabI酶是TCS在细菌中的主要作用靶点。目前,已经在环境中发现了多种FabI突变体和同工酶,使细菌对TCS产生耐药性。此外,在实验室实验和环境环境(如厌氧消化池)中,研究了TCS促进细菌对其他抗菌剂产生耐药性的机制。TCS将促进环境中抗菌素耐药性的发展,并可能对公众健康造成不利风险。本文系统综述了TCS驱动细菌耐药的机制,重点介绍了TCS在促进抗生素耐药基因(ARGs)水平转移和富集方面的作用。提出了克服实验室规模研究的局限性,进一步完善TCS环境风险评估的建议。
{"title":"Effects of Triclosan on the Development of Antimicrobial Resistance in the Environment: A Review","authors":"Chunzhen Wang,&nbsp;Shihai Liu,&nbsp;Haodi Feng,&nbsp;Holly Barrett,&nbsp;Hui Peng,&nbsp;S. H. P. Parakrama Karunaratne,&nbsp;Yu Zhang,&nbsp;Min Yang","doi":"10.1007/s40726-023-00270-x","DOIUrl":"10.1007/s40726-023-00270-x","url":null,"abstract":"<div><h3>Purpose of Review</h3><p>Triclosan (TCS), a widely used broad-spectrum antimicrobial agent, enters to wastewater treatment plants (WWTPs) and the environment ultimately after its usage. Notably, the use of TCS has surged during the outbreak of COVID-19, leading to the environment under increasing TCS pollution pressure. Even environmentally relevant concentrations of TCS can promote the development of antimicrobial resistance (AMR), which is a major public health concern. The purpose of this study is to provide a basis for the management and risk assessment of TCS by providing a holistic review of the impact of TCS on AMR in the environment.</p><h3>Recent Findings</h3><p>Bacterial resistance to TCS mainly takes place through modification or replacement of the FabI enzyme, which is the main target of TCS in bacteria. Currently, multiple FabI mutants and isoenzymes have been identified in the environment giving bacterial resistance to TCS. In addition, mechanisms by which TCS promotes bacterial development of resistance to other antimicrobials have been studied in laboratory experiments and environmental settings, such as anaerobic digester. TCS will promote the development of AMR in the environment with the possibility of adverse risks to public health.</p><h3>Summary</h3><p>This review systematically summarizes the mechanisms of bacterial resistance to antimicrobials driven by TCS and highlights the effects of TCS in promoting the horizontal transfer and enrichment of antibiotic resistance genes (ARGs). Suggestions for overcoming the limitations of laboratory-scale studies and further improving the risk assessment of TCS in the environment are proposed.\u0000</p></div>","PeriodicalId":528,"journal":{"name":"Current Pollution Reports","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40726-023-00270-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6713711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Ventilation Rates with Building Design in Various Built Environments: A Critical Review 不同建筑环境中通风率与建筑设计的关系:一个重要的回顾
IF 7.3 2区 环境科学与生态学 Q1 Environmental Science Pub Date : 2023-06-17 DOI: 10.1007/s40726-023-00271-w
Baby Keerthi Thirunagari, Rajyalakshmi Garaga, Sri Harsha Kota

Building ventilation rate is a crucial factor in the indoor air quality (IAQ). Furthermore, building-related parameters (window geometry, building orientation, height, and shape) have a substantial impact on the ventilation rates. However, most building designs reported in the literature from various income group countries failed to fulfill the recommended ventilation standards. A systematic and critical review was conducted on the collated literature from the past 20 years using various databases, yielding 145 related articles. Building-related factors influencing the ventilation rates were thoroughly studied in different income groups. In addition, the existing ventilation rates in various building environments were examined. The data analysis of critical literature suggests that the ventilation rates in 80% of the building environments were found lower than the prescribed standards irrespective of the income group countries. Thus, the current study highlights the need for redesign of the existing or new buildings for meeting the adequate ventilation rates.

建筑通风量是影响室内空气质量的重要因素。此外,与建筑相关的参数(窗户几何形状、建筑朝向、高度和形状)对通风率有重大影响。然而,来自不同收入群体国家的文献中报道的大多数建筑设计未能达到推荐的通风标准。对过去20年的文献进行了系统和批判性的审查,使用各种数据库,产生145篇相关文章。对不同收入群体影响通风率的建筑相关因素进行了深入研究。此外,还研究了不同建筑环境的现有通风率。关键文献的数据分析表明,无论收入群体如何,80%的建筑环境的通风率都低于规定的标准。因此,目前的研究强调需要重新设计现有或新的建筑物,以满足足够的通风率。
{"title":"Association of Ventilation Rates with Building Design in Various Built Environments: A Critical Review","authors":"Baby Keerthi Thirunagari,&nbsp;Rajyalakshmi Garaga,&nbsp;Sri Harsha Kota","doi":"10.1007/s40726-023-00271-w","DOIUrl":"10.1007/s40726-023-00271-w","url":null,"abstract":"<div><p>Building ventilation rate is a crucial factor in the indoor air quality (IAQ). Furthermore, building-related parameters (window geometry, building orientation, height, and shape) have a substantial impact on the ventilation rates. However, most building designs reported in the literature from various income group countries failed to fulfill the recommended ventilation standards. A systematic and critical review was conducted on the collated literature from the past 20 years using various databases, yielding 145 related articles. Building-related factors influencing the ventilation rates were thoroughly studied in different income groups. In addition, the existing ventilation rates in various building environments were examined. The data analysis of critical literature suggests that the ventilation rates in 80% of the building environments were found lower than the prescribed standards irrespective of the income group countries. Thus, the current study highlights the need for redesign of the existing or new buildings for meeting the adequate ventilation rates.\u0000</p></div>","PeriodicalId":528,"journal":{"name":"Current Pollution Reports","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6713728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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