Douleurs最新文献

{"title":"Efficacy of chitosan mouthwash for oral mucositis: A promising therapeutic approach for head and neck cancer patients following radiotherapy","authors":"Karthikeya Patil ,&nbsp;Sanjay Chikkarasinakere Jogigowda ,&nbsp;Mahima V. Guledgud ,&nbsp;Varusha Sharon Christopher ,&nbsp;Vidya Gowdappa Doddawad ,&nbsp;Pushpa Vittalanahalli Hutchappa","doi":"10.1016/j.douler.2024.03.004","DOIUrl":"10.1016/j.douler.2024.03.004","url":null,"abstract":"<div><h3>Background</h3><p>Chitosan, a biopolymer made from the chitin found in crab shells, has notably come into play because of its multitude of functionalities in oral healthcare. Chitosan has exceptional antibacterial characteristics that enable it to successfully fight off oral germs that cause bad breath, tooth plaque, and gum disease. Moreover, mouthwashes made from chitosan are known for being non-toxic and biocompatible, which promotes tissue repair and offers a healthy alternative to conventional mouthwashes.</p></div><div><h3>Aims and objective</h3><p>The purpose of this study is to assess the effectiveness of chitosan mouthwash for oral mucositis among head and neck cancer patients who had undergone radiotherapy by analysing clinical parameter scores, including VAS, OMAS, and WHO.</p></div><div><h3>Materials and methods</h3><p>This is an in vivo observational study that consists of forty head and neck cancer patients under radiotherapy who have oral mucositis and agreed to participate. The control group (<em>n</em> <!-->=<!--> <!-->20) used chlorhexidine mouthwash and the study group (<em>n</em> <!-->=<!--> <!-->20) used chitosan mouthwash. All patients underwent clinical evaluations for pain/discomfort, ulcers and erythema, and severity of mucositis using VAS, OMAS, and WHO mucositis scores subsequently every 20 days after the start of radiation.</p></div><div><h3>Results</h3><p>The effectiveness of the chitosan mouthwashes in the study group showed reduced mucositis symptoms compared to the control group, with statistical significance.</p></div><div><h3>Conclusion</h3><p>Chitosan, a naturally derived biopolymer from chitin, holds great potential in the treatment of oral mucositis due to its anti-inflammatory properties, and it has a positive overall impact on the quality of life.</p></div><div><h3>Contexte</h3><p>Le chitosane, un biopolymère fabriqué à partir de la chitine présente dans les carapaces de crabe, est notamment entré en jeu en raison de sa multitude de fonctionnalités en santé buccodentaire. Le chitosane possède des caractéristiques antibactériennes exceptionnelles qui lui permettent de combattre avec succès les germes buccaux responsables de la mauvaise haleine, de la plaque dentaire, et des maladies des gencives. De plus, les bains de bouche à base de chitosane sont connus pour être non toxiques et biocompatibles, ce qui favorise la réparation des tissus et offre une alternative saine aux bains de bouche classiques.</p></div><div><h3>Buts et objectifs</h3><p>Le but de cette étude est d’évaluer l’efficacité du bain de bouche au chitosane pour la mucite buccale chez les patients atteints d’un cancer de la tête et du cou et ayant subi une radiothérapie. Pour cela, une analyse des scores des paramètres cliniques, notamment VAS, OMAS, et OM, a été menée.</p></div><div><h3>Matériel et méthodes</h3><p>Il s’agit d’une étude observationnelle in vivo portant sur quarante patients atteints d’un cancer de la tête et du cou, sous","PeriodicalId":53699,"journal":{"name":"Douleurs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}