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Fast Detection of Acute Lymphoblastic Leukemia Through Stacked Pre-trained Ensemble Learning and Efficient Segmentation 基于堆叠预训练集成学习和高效分割的急性淋巴细胞白血病快速检测
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-09 DOI: 10.1007/s13369-025-10404-6
Muhammad A. O. Ahmed, Raed Alotaibi, Yasser Abdel Satar, Nora Gaber, Nahla F. Omran, Omar Reyad

Acute lymphoblastic leukemia (ALL) is a critical hematological malignancy where prompt and accurate diagnosis is essential for effective treatment. This study proposes a novel methodology combining efficient image segmentation with a stacked ensemble of pre-trained convolutional neural networks (CNNs) and XGBoost (FXGBoost) for accurately classifying peripheral blood smear (PBS) images. The used dataset includes 3,256 annotated PBS images from 89 patients covering benign and malignant cases. The proposed model achieves outstanding diagnostic performance, with an accuracy of 99.39% and an F1-score of 0.9963, outperforming several existing deep learning and ensemble methods. Statistical validation using confidence intervals and Tukey honestly significant difference (HSD) testing confirms the results’ significance. Comparative evaluations also include transformer-based models, and inference time per image (ITP) analysis, which is provided to assess computational feasibility. To ensure clinical applicability, we incorporate model interpretability using Gradient-weighted Class Activation Map (Grad-CAM) and address challenges such as class imbalance and overfitting. We acknowledge limitations related to dataset scope and generalizability, and future directions include domain adaptation, explainability enhancement, and real-time deployment. This work contributes a robust and clinically relevant framework for ALL diagnoses, demonstrating how AI-based tools can augment medical decision-making in real-world settings.

急性淋巴细胞白血病(ALL)是一种严重的血液系统恶性肿瘤,及时准确的诊断是有效治疗的必要条件。本研究提出了一种新的方法,将有效的图像分割与预训练卷积神经网络(cnn)和XGBoost (FXGBoost)的堆叠集成相结合,用于准确分类外周血涂片(PBS)图像。使用的数据集包括来自89名患者的3256张带注释的PBS图像,包括良性和恶性病例。该模型的诊断准确率为99.39%,f1分数为0.9963,优于现有的几种深度学习和集成方法。统计验证采用置信区间和Tukey诚实显著差异(HSD)检验证实了结果的显著性。比较评价还包括基于变压器的模型,以及用于评估计算可行性的每图像推断时间(ITP)分析。为了确保临床适用性,我们使用梯度加权分类激活图(Grad-CAM)结合模型的可解释性,并解决分类不平衡和过拟合等挑战。我们承认与数据集范围和概括性相关的局限性,未来的方向包括领域适应、可解释性增强和实时部署。这项工作为ALL诊断提供了一个强大的临床相关框架,展示了基于人工智能的工具如何在现实环境中增强医疗决策。
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引用次数: 0
Exploring Social Media Addiction Using an Adapted Distance Measure Through Hybrid Pythagorean MCDM Methodology 通过混合毕达哥拉斯MCDM方法,使用自适应距离测量探索社交媒体成瘾
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-09 DOI: 10.1007/s13369-025-10402-8
Naveen Kumar, Juthika Mahanta

The increasing prevalence of social media addiction among adolescents has become a significant concern, often exceeding other harmful behaviors. Evaluating the addictive potential of various platforms is challenging due to the diversity of applications and the subjectivity inherent in expert judgments. To address these complexities, this study proposes a novel distance measure within the Pythagorean fuzzy set framework, designed to overcome the limitations of existing measures, which often yield inaccurate or inconsistent results in specific contexts. To support the mathematical validity of the proposed measure, its geometric behavior is analyzed, and a comparative study with existing distance functions is conducted using numerical examples. A comprehensive multi-criteria decision-making framework is then developed, incorporating the method based on the removal effects of criteria (MEREC) for objective weighting and stepwise weight assessment ratio analysis (SWARA) for subjective weighting. These weights are integrated using the technique for order of preference by similarity to the ideal solution (TOPSIS) to rank social media platforms based on their addiction potential. Sensitivity and comparative analyses confirm the robustness, reliability, and consistency of the proposed approach. The study concludes by demonstrating the advantages of the framework and identifying potential directions for future research.

社交媒体成瘾在青少年中越来越普遍,这已经成为一个重大问题,往往超过其他有害行为。由于应用程序的多样性和专家判断固有的主观性,评估各种平台的成瘾潜力是具有挑战性的。为了解决这些复杂性,本研究在毕达哥拉斯模糊集框架内提出了一种新的距离测量方法,旨在克服现有测量方法的局限性,这些方法在特定情况下通常会产生不准确或不一致的结果。为了支持所提测度的数学有效性,分析了其几何行为,并通过数值算例与现有距离函数进行了比较研究。然后建立了一个综合的多准则决策框架,将基于准则去除效应的方法(MEREC)用于客观加权,逐步加权评估比率分析法(SWARA)用于主观加权。这些权重通过与理想解决方案相似度的偏好排序技术(TOPSIS)进行整合,根据社交媒体平台的成瘾潜力对其进行排名。灵敏度和比较分析证实了该方法的稳健性、可靠性和一致性。最后,本研究展示了该框架的优势,并确定了未来研究的潜在方向。
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引用次数: 0
Improve Thermal Sensing Drones for Emergency Response: A Comprehensive Control System Approach 改进热传感无人机应急响应:一种综合控制系统方法
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-09 DOI: 10.1007/s13369-025-10368-7
Lina Ali Shakir, Sefer Kurnaz, Ahmed Alkhayyat

Unmanned aerial systems equipped with thermal imaging cameras are vital for effective emergency response, especially in firefighting scenarios. These drones require high stability, rapid responsiveness, and precise positioning, all of which depend on advanced control systems. This study introduces an innovative approach using an Interval Genetic Algorithm to optimize Proportional–Integral–Derivative (PID) and H2 controllers, enhancing the performance of thermal imaging drones for emergency response and surveillance applications. A comprehensive mathematical model was developed to simulate quadcopter dynamics in both “ + ” and “X” configurations. The challenges of PID tuning and the limitations of H2 controllers in real-world environments were addressed, resulting in improved drone stability and control under demanding conditions. The results demonstrate a significant enhancement in altitude control and motor speed stabilization, with an average increase of 20% in control precision and a 15% reduction in system response time compared to traditional control methods. These findings advance drone technology by providing more reliable and efficient tools for emergency responders.

配备热像仪的无人机系统对于有效的应急响应至关重要,特别是在消防场景中。这些无人机需要高稳定性、快速响应和精确定位,所有这些都依赖于先进的控制系统。本研究引入了一种利用区间遗传算法优化比例-积分-导数(PID)和H2控制器的创新方法,提高了热成像无人机在应急响应和监视应用中的性能。建立了一个综合的数学模型来模拟“+”和“X”两种构型的四轴飞行器动力学。解决了PID整定的挑战和H2控制器在现实环境中的局限性,从而提高了无人机在苛刻条件下的稳定性和控制能力。结果表明,与传统控制方法相比,该方法在高度控制和电机速度稳定性方面有显著提高,控制精度平均提高20%,系统响应时间减少15%。这些发现通过为应急人员提供更可靠、更有效的工具,推动了无人机技术的发展。
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引用次数: 0
Adsorption of CO2 Using NaOH-Modified Nanoclay Montmorillonite Adsorbent: Comparative Analysis of RSM-Based Central Composite Design and ANN-Based Models in Modelling and Optimization naoh改性纳米粘土蒙脱土吸附剂对CO2的吸附:基于rsm的中心复合设计与基于ann的建模与优化模型的比较分析
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-08 DOI: 10.1007/s13369-025-10401-9
Irvan Dahlan, Mahfuzah Hanisah Mohd Suhaimi

The increasing need for efficient CO2 capture methods has led to the exploration of NaOH-modified nanoclay montmorillonite as an adsorbent. This study utilizes response surface methodology (RSM) and artificial neural networks (ANN) for modelling and optimizing CO2 adsorption. Data from previous experiments were used to develop the models. RSM employed a central composite design (CCD) and was evaluated using analysis of variance (ANOVA), while ANN models were created with various training methods (Levenberg–Marquardt, Bayesian regularization, and scaled conjugate gradient). The ANN model using Bayesian regularization (R2 = 0.98719; MSE = 0.00049) demonstrated the best predictive accuracy. ANOVA revealed that NaOH concentration, pressure, and temperature significantly affected CO2 adsorption capacity. Sensitivity analysis confirmed NaOH concentration as the most influential variable. Optimization results indicated that maximum CO2 adsorption (72.873 mg/g) occurs at 35 °C, 9 bar pressure, 5 mol/L acid concentration, and 30% w/w NaOH. This study effectively applies RSM-CCD and ANN models for optimizing CO2 adsorption with NNM adsorbent.

对高效二氧化碳捕集方法的需求日益增长,导致了naoh改性纳米粘土蒙脱土作为吸附剂的探索。本研究利用响应面法(RSM)和人工神经网络(ANN)对CO2吸附进行建模和优化。以前的实验数据被用来建立模型。RSM采用中心复合设计(CCD),并使用方差分析(ANOVA)进行评估,而ANN模型则使用各种训练方法(Levenberg-Marquardt,贝叶斯正则化和缩放共轭梯度)创建。采用贝叶斯正则化的人工神经网络模型(R2 = 0.98719, MSE = 0.00049)的预测准确率最高。方差分析表明,NaOH浓度、压力和温度对CO2吸附能力有显著影响。敏感性分析证实NaOH浓度是影响最大的变量。优化结果表明,在35℃,9 bar压力,5 mol/L酸浓度,30% w/w NaOH条件下,CO2吸附量最大,达到72.873 mg/g。本研究有效地应用了RSM-CCD和ANN模型来优化NNM吸附剂对CO2的吸附。
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引用次数: 0
The Effect of Intercritical Annealing Temperature, Martensite Volume Fraction and Martensite Grain Size on Microstructure and Mechanical Properties of Pre-Alloyed Powder Metallurgy Dual-Phase Steels 临界间退火温度、马氏体体积分数和马氏体晶粒尺寸对预合金粉末冶金双相钢组织和力学性能的影响
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-07 DOI: 10.1007/s13369-025-10410-8
Özer Pamuk

In this study, the effects of intercritical annealing (ICA) temperature, martensite volume fraction (MVF), and martensite grain size (MGS) on the microstructure and mechanical properties of pre-alloyed powder metallurgy (PM) steel parts subjected to dual-phase (DP) treatment were investigated. Sintering (S), normalization (N), quenching (Q), and DP heat treatments were applied to the parts manufactured by warm pressing method. Afterward, mechanical testing and microstructure characterizations were carried out. A dual-phase microstructure with a homogeneous distribution in pre-alloyed PM steel parts was successfully produced with DP heat treatment. MVF and MGS increased as the ICA temperature increased. At the same ICA temperature, small MGS caused low MVF. DP heat treatment increased the strength and hardness of sintered pre-alloyed PM steel parts but decreased their ductility. As MVF increased at different ICA temperatures, strength and hardness increased but ductility decreased. In these samples, the highest strength of 241 MPa and the highest hardness of 174 HBW were obtained in SNDP-750 sample containing 48.87% MVF. This sample exhibited a low uniform elongation (0.68%). At the same ICA temperatures, as MGS of the samples got smaller, their strength and hardness increased but they exhibited a similar ductility. The highest strength of 242 MPa and the highest hardness of 169 HBW were observed in the SQDP-740 sample containing 2.91 μm MGS. This sample exhibited a uniform elongation of 2.15%. The results showed that DP heat treatment improved the mechanical properties of sintered pre-alloyed PM steels.

本文研究了临界间退火(ICA)温度、马氏体体积分数(MVF)和马氏体晶粒尺寸(MGS)对双相(DP)预合金粉末冶金(PM)钢零件组织和力学性能的影响。对热压制件进行了烧结(S)、正火(N)、淬火(Q)和DP热处理。随后进行了力学性能测试和显微组织表征。采用DP热处理技术,成功制备了预合金PM钢零件的双相组织。MVF和MGS随ICA温度升高而升高。在相同的ICA温度下,较小的MGS导致较低的MVF。DP热处理提高了烧结预合金PM钢零件的强度和硬度,但降低了其塑性。在不同ICA温度下,随着MVF的增加,强度和硬度增加,但延展性降低。其中,MVF含量为48.87%的SNDP-750试样强度最高,为241 MPa,硬度最高,为174 HBW。样品的均匀伸长率较低(0.68%)。在相同的ICA温度下,试样的MGS越小,其强度和硬度越高,但其延展性相似。含2.91 μm mg的SQDP-740试样的最高强度为242 MPa,最高硬度为169 HBW。该样品的均匀伸长率为2.15%。结果表明,DP热处理改善了烧结预合金PM钢的力学性能。
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引用次数: 0
Enhanced Photocatalytic Degradation of Pharmaceutical Pollutants Using Copper-Doped TiO2: Optimization, Machine Learning Integration, and Ecological Safety Assessment 铜掺杂TiO2增强光催化降解药物污染物:优化、机器学习集成和生态安全性评估
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-06 DOI: 10.1007/s13369-025-10394-5
Haroun Hafsa, Noureddine Nasrallah, Sara Zeghbib, Mohammed Kebir, Hichem Tahraoui, Amine Aymen Assadi, Lotfi Khezami, AbdulAziz Alghamdi, Nadjib Dahdouh, Sabrina Lekmine, Abdeltif Amrane

Pharmaceutical contaminants in wastewater represent a growing environmental concern due to their persistence and potential ecological impacts. This study proposes a sustainable approach by developing copper-doped titanium dioxide (Cu–TiO2) nanoparticles for the effective removal of cetirizine hydrochloride (CTZ-H), a widely used antihistamine frequently detected in effluents. Cu–TiO2 photocatalysts were synthesized via the impregnation method with varying copper loadings (0.5–3 wt%) and thoroughly characterized. Their photocatalytic performances were evaluated under natural sunlight, considering the effects of dopant concentration, solution pH, catalyst dosage, and pollutant concentration. Optimal degradation efficiency of 93% was achieved using 0.5 wt% Cu–TiO2 at pH 4.9, a catalyst dose of 100 mg/L, and an initial CTZ-H concentration of 10 mg/L. Kinetic modeling indicated a pseudo-first-order reaction with a rate constant (k_CTZ-H) of 0.025 min⁻1. Phytotoxicity assays using lentil seeds demonstrated significantly reduced toxicity of the treated water, supporting its potential for safe environmental discharge or reuse. Additionally, the Support Vector Machine (SVM) model coupled with the Improved Grey Wolf Optimizer (IGWO) accurately predicted photocatalytic degradation outcomes, with a correlation coefficient (R) of 0.9999. These results underscore the promise of Cu-doped TiO2 as an efficient and eco-friendly photocatalyst for mitigating pharmaceutical pollution in aquatic environments.

废水中的药物污染物由于其持久性和潜在的生态影响而日益受到环境问题的关注。本研究提出了一种可持续的方法,通过开发铜掺杂二氧化钛(Cu-TiO2)纳米颗粒来有效去除盐酸西替利嗪(CTZ-H),这是一种广泛使用的抗组胺药,经常在污水中检测到。采用浸渍法制备了不同铜负载量(0.5 ~ 3 wt%)的Cu-TiO2光催化剂,并对其进行了表征。考虑掺杂剂浓度、溶液pH、催化剂用量和污染物浓度的影响,在自然光照下评价了它们的光催化性能。在pH为4.9、催化剂剂量为100 mg/L、CTZ-H初始浓度为10 mg/L的条件下,Cu-TiO2浓度为0.5 wt%,降解效率为93%。动力学模型表明这是一个伪一级反应,速率常数(k_CTZ-H)为0.025 min毒血症。使用扁豆种子进行的植物毒性试验表明,处理后的水的毒性显著降低,支持其安全排放或再利用的潜力。此外,支持向量机(SVM)模型与改进的灰狼优化器(IGWO)相结合能够准确预测光催化降解结果,相关系数(R)为0.9999。这些结果强调了cu掺杂TiO2作为一种高效环保的光催化剂在水生环境中减轻药物污染的前景。
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引用次数: 0
An Improved Fata Morgana Algorithm for Global Optimization 一种改进的Fata Morgana全局优化算法
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-05 DOI: 10.1007/s13369-025-10393-6
Peng Wei, Chaochuan Jia, ZhongRong Shi, Maoshen Fu, Xiancun Zhou, Li Ling

The fata morgana algorithm (FATA) is a novel swarm intelligence optimization algorithm, and its design inspiration stems from the unique natural phenomenon of mirages. To overcome the premature convergence of the FATA, which leads to its entrapment in local optimal solutions, an improved FATA (IMFATA) is proposed in this paper based on a circle chaotic map and adaptivee t-Distribution perturbation mutation. The IMFATA is validated against the FATA on 23 benchmark functions and CEC2021 test functions and compared with the honey badger algorithm (HBA), beluga whale optimization (BWO), the whale optimization algorithm (WOA),the goose algorithm(GOOSE), the dung beetle optimizer (DBO), and the aquila optimizer (AO). The experimental results show that the IMFATA can effectively improve its computational accuracy and convergence speed, and its global optimization ability is superior to that of the other algorithms. Finally, the IMFATA is applied to optimize the parameters of a support vector machine (SVM) for Dendrobium grade classification. The experimental results show that the classification accuracy (F1 value) achieved for the Dendrobium grades optimized by the IMFATA is relatively high, fully demonstrating the superiority of the IMFATA in practical engineering applications.

fata morgana算法(fata)是一种新颖的群体智能优化算法,其设计灵感源于海市蜃景这一独特的自然现象。为了克服FATA算法的过早收敛性导致其陷入局部最优解,本文提出了一种基于圆形混沌映射和自适应t分布扰动突变的改进FATA算法。在23个基准函数和CEC2021测试函数上对该算法进行了验证,并与蜜獾算法(HBA)、白鲸优化算法(BWO)、鲸鱼优化算法(WOA)、鹅算法(goose)、屎壳虫优化器(DBO)和aquila优化器(AO)进行了比较。实验结果表明,该算法可以有效地提高计算精度和收敛速度,其全局优化能力优于其他算法。最后,应用IMFATA对支持向量机(SVM)的石斛等级分类参数进行优化。实验结果表明,IMFATA对优化后的石斛等级的分类精度(F1值)较高,充分体现了IMFATA在实际工程应用中的优越性。
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引用次数: 0
Advancing Bearing Fault Diagnosis Using Deep Transfer Learning for Wireless Sensor Networks 基于深度迁移学习的无线传感器网络轴承故障诊断
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-05 DOI: 10.1007/s13369-025-10387-4
Sidahmed Lachenani, Hamza Kheddar, Mohamed Ould Zmirli

Traditional deep learning (DL) models face key limitations in bearing fault detection within wireless sensor networks (WSNs). They require high computational power and large labeled datasets–resources often unavailable in WSNs due to energy, memory, and processing constraints. The scarcity of some bearing fault classes limits the availability of labeled data, complicating effective model training. Additionally, DL models struggle to generalize across varying operating conditions and sensor types, limiting their robustness. Such constraints highlight the inadequacy of conventional DL in WSN-based fault diagnosis and support the use of advanced DL technique compatible with the resource limitations of WSN platforms. This work presents bearing network BearNet, a novel technique designed to enhance bearing fault diagnosis, that strengthens the functionalities of WSN technology in detecting bearing fault by using the concept of transfer learning (TL) with the pre-trained Yet another audio mobilenet network (YAMNet) neural network. Our method converts sensor data into Mel spectrograms, which serve as critical features for training our neural network model. The application of pre-trained YAMNet, along with our tailored target DL model, allows for efficient and accurate classification of different classes of bearing faults. The proposed architecture addresses the constraints of WSNs, such as limited processing capabilities, by utilizing only the unfrozen and additional layers during validation and testing, rather than the entire YAMNet model, thereby optimizing resource usage. Empirical results conducted on the CWRU and MFPT datasets demonstrate that our BearNet technique achieves high diagnostic accuracy, showing significant improvements of 3.1% and between 0.02–5.26% compared to pure YAMNet and state-of-the-art models, respectively. This validates its effectiveness for practical condition monitoring applications across various industrial settings.

传统的深度学习(DL)模型在无线传感器网络(WSNs)的轴承故障检测中存在很大的局限性。它们需要高计算能力和大型标记数据集——由于能量、内存和处理限制,这些资源通常在wsn中不可用。一些轴承故障类别的稀缺性限制了标记数据的可用性,使有效的模型训练复杂化。此外,深度学习模型难以在不同的操作条件和传感器类型中进行泛化,从而限制了它们的鲁棒性。这些约束突出了传统深度学习在基于WSN的故障诊断中的不足,并支持使用与WSN平台资源限制兼容的高级深度学习技术。本文提出了轴承网络BearNet,这是一种旨在增强轴承故障诊断的新技术,通过使用迁移学习(TL)的概念和预训练的另一种音频移动网络(YAMNet)神经网络,增强了WSN技术在检测轴承故障方面的功能。我们的方法将传感器数据转换为Mel谱图,作为训练神经网络模型的关键特征。预先训练的YAMNet的应用,以及我们量身定制的目标深度学习模型,允许对不同类别的轴承故障进行有效和准确的分类。所提出的体系结构通过在验证和测试期间仅利用未冻结层和附加层,而不是整个YAMNet模型,解决了wsn的约束,例如有限的处理能力,从而优化了资源使用。在CWRU和MFPT数据集上进行的实证结果表明,我们的BearNet技术达到了很高的诊断准确率,与纯YAMNet和最先进的模型相比,分别提高了3.1%和0.02-5.26%。这验证了其在各种工业环境中实际状态监测应用的有效性。
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引用次数: 0
Cobalt/Copper Doped Bimetallic Zeolitic Imidazolate Frameworks as Peroxymonosulfate Activators for the Removal of Veterinary Antibiotics: Response Surface Modeling and Optimization of Reaction Parameters 钴/铜掺杂双金属沸石咪唑酸框架作为过氧单硫酸盐活化剂:响应面建模及反应参数优化
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-05 DOI: 10.1007/s13369-025-10392-7
Esra Yılmaz Mertsoy, Burcu Palas

Activation of peroxymonosulfate (PMS) by Co and Cu doped zeolitic imidazolate framework, ZIF-8 s for degradation of sulfamethazine (SMZ) was investigated. It was observed that combination of the two metals increased the PMS activation efficiency by using the activity of both metal redox pairs to increase the production of sulfate and hydroxyl radicals. Different characterization techniques, including nitrogen (N2) adsorption, Fourier-transform infrared (FTIR), scanning electron microscopy energy-dispersive spectroscopy (SEM–EDS mapping), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA), were used to characterize the synthesized catalysts, ZIF-8, Cu/ZIF-8, and Co/ZIF-8. No structural differences were observed in catalysts obtained after bimetallic synthesis. The BET surface area was calculated as 1145, 742, 945 m2/g for ZIF-8, Cu/ZIF-8, and Co/ZIF-8, respectively. Under reaction conditions of 0.1 g/L PMS dosage, 0.5 g/L catalyst dosage, and original pH, sulfamethazine degradation after 30 min was 10.5% with PMS alone (no catalyst), 28.0% with ZIF-8, 33.9% with Cu/ZIF-8, and 58.4% with Co/ZIF-8, clearly demonstrating the superior catalytic performance of Co/ZIF-8. Using Box–Behnken design and response surface methodology, reaction parameters were optimized in the presence of the most efficient catalyst, Co/ZIF-8. The sulfamethazine removal was optimized at 0.55 g/L catalyst dosage, pH 5.2 and 0.15 g/L PMS dosage. Under the optimal reaction conditions 67.3% sulfamethazine removal was achieved within 30 min in the presence of Co/ZIF-8 as catalyst. Scavenging experiments showed that the dominant reactive oxygen species was hydroxyl radicals. According to the phytotoxicity test performed by using L. sativum, 35.9% growth inhibition was evaluated.

研究了Co和Cu掺杂的沸石咪唑酸框架zif - 8s对过氧单硫酸盐(PMS)降解磺胺乙嘧啶(SMZ)的活化作用。结果表明,两种金属的结合通过利用两种金属氧化还原对的活性来增加硫酸盐和羟基自由基的产生,从而提高了PMS的活化效率。采用氮(N2)吸附、傅里叶变换红外(FTIR)、扫描电子显微镜能谱(SEM-EDS)、x射线光电子能谱(XPS)和热重分析(TGA)等表征技术对合成的ZIF-8、Cu/ZIF-8和Co/ZIF-8进行了表征。双金属合成后得到的催化剂无结构差异。ZIF-8、Cu/ZIF-8和Co/ZIF-8的BET表面积分别为1145、742、945 m2/g。在PMS用量为0.1 g/L、催化剂用量为0.5 g/L、初始pH条件下,反应30 min后,PMS单独(无催化剂)对磺胺乙嘧啶的降解率为10.5%,ZIF-8为28.0%,Cu/ZIF-8为33.9%,Co/ZIF-8为58.4%,可见Co/ZIF-8具有较好的催化性能。采用Box-Behnken设计和响应面法,在Co/ZIF-8催化剂的存在下,对反应参数进行优化。催化剂用量为0.55 g/L、pH值为5.2、PMS用量为0.15 g/L时,磺胺乙胺的去除率最佳。在最佳反应条件下,以Co/ZIF-8为催化剂,30 min内可脱除67.3%的磺胺乙嘧啶。清除实验表明,主要的活性氧是羟基自由基。经植物毒性试验,其生长抑制率为35.9%。
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引用次数: 0
Development and Characterization of PMMA/PVP Nanofiber-Loaded Bioactive Agents with Enhanced Breast Cancer Activity 具有增强乳腺癌活性的PMMA/PVP纳米纤维负载生物活性剂的开发和表征
IF 2.9 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-07-04 DOI: 10.1007/s13369-025-10288-6
Shaimaa S. Goher, Esraa B. Abdelazim, Marwa A. Aleem, Samar A. Salim

Breast cancer remains a leading cause of cancer-related mortality globally, driving the need for novel effective and less toxic therapeutic agents. This study explores the synthesis and characterization of bioactive compounds: 1-(4-methoxyphenyl)-N-(p-tolyl)methanimine (MPTI), N-(4-methylphenyl)benzamide (MPB), and 4-methyl-N-(p-tolyl)benzenesulfonamide (MTS), and their incorporation into a PMMA/PVP polymer matrix for potential anticancer applications. Morphological analysis of the PMMA/PVP-loaded agents via SEM depicts structural modifications in the PMMA/PVP nanofibrous matrix upon incorporation of the bioactive agents. The FTIR analysis of the synthesized compounds before and after loading into the 7PMMA:3PVP nanofibers reveals successful incorporation of MPTI, MPB, and MTS, with characteristic absorption bands confirming their molecular structures and interactions within the polymeric blend. Moreover, XRD diffractograms showed a transition to an amorphous state upon incorporation of the synthesized compounds into the polymer blend confirming full encapsulation. In vitro release studies showed a sustained release profile of the bioactive agents, with initial burst releases observed over a period of 3 days. Cytotoxicity assays against the MCF-7 breast cancer cell line revealed significant concentration-dependent effects, with MTS exhibiting the highest efficacy. Notably, the PMMA/PVP matrix reduced the cytotoxicity of the formulations, suggesting a protective effect that enhances safety. The findings indicate that the PMMA/PVP system may serve as an effective platform for delivering these bioactive agents for anticancer applications.

乳腺癌仍然是全球癌症相关死亡的主要原因,这推动了对新型有效且毒性较小的治疗药物的需求。本研究探讨了1-(4-甲氧基苯基)-N-(对甲基苯基)甲亚胺(MPTI)、N-(4-甲基苯基)苯酰胺(MPB)和4-甲基-N-(对甲基苯基)苯磺酰胺(MTS)等生物活性化合物的合成和表征,并将其掺入PMMA/PVP聚合物基质中,用于潜在的抗癌应用。通过扫描电镜对PMMA/PVP负载剂进行形态学分析,描述了加入生物活性剂后PMMA/PVP纳米纤维基质的结构变化。通过FTIR分析,合成的化合物在加载到7PMMA:3PVP纳米纤维之前和之后成功地掺入了MPTI、MPB和MTS,其特征吸收带证实了它们在聚合物共混物中的分子结构和相互作用。此外,XRD衍射图显示,当合成的化合物加入到聚合物共混物中时,其转变为无定形状态,证实了聚合物的完全封装。体外释放研究显示了生物活性药物的持续释放特征,在3天内观察到初始爆发释放。对MCF-7乳腺癌细胞系的细胞毒性试验显示出显著的浓度依赖性,其中MTS表现出最高的效果。值得注意的是,PMMA/PVP基质降低了配方的细胞毒性,表明具有增强安全性的保护作用。研究结果表明,PMMA/PVP系统可以作为一种有效的平台,为抗癌应用提供这些生物活性药物。
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Arabian Journal for Science and Engineering
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