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Effects of perinatal asphyxia on cortical activity in two-year-old children 围产期窒息对两岁儿童皮质活动的影响。
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103933
Sebastian König , Anna Tuiskula , Marjo Metsäranta , Susanna Stjerna , Emma Saure , Leena Haataja , Sampsa Vanhatalo , Anton Tokariev
Perinatal asphyxia can lead to clinical hypoxic-ischemic encephalopathy (HIE) associated with high morbidity and mortality, but less is known about long-lasting effects of perinatal asphyxia alone (PA). Here, we investigate how PA with versus without clinical HIE affects cortical activity networks at two years of age. Electroencephalographic (EEG) recordings were acquired during sleep from three cohorts of children (PA only (n = 10), PA with mild to moderate HIE (n = 8), and healthy controls (n = 37)), and we assessed the group differences in local cortical function and cortico-cortical networks. Compared with the healthy controls, both PA and HIE were linked to reduced frequency-specific amplitudes. In two-year-old children with PA, the amplitude-related networks were stronger at low frequencies and weaker at higher frequencies, however, two-year-olds with HIE showed decreased connectivity at all frequencies. Likewise, phase-related networks in children with PA were stronger at lower frequencies and weaker at higher frequencies. Local phase-amplitude coupling was affected by PA or HIE in only a few cortical regions. Our findings suggest that PA, even without clinical HIE, may be associated with long-lasting changes to both local cortical activity and the large-scale cortical networks, which could potentially affect normal brain functions.
围产期窒息可导致临床缺氧缺血性脑病(HIE),具有高发病率和死亡率,但对围产期窒息的长期影响知之甚少(PA)。在这里,我们研究了两岁时PA伴与不伴临床HIE对皮质活动网络的影响。我们从三组儿童(仅PA (n = 10), PA合并轻度至中度HIE (n = 8)和健康对照(n = 37))中获取睡眠期间的脑电图(EEG)记录,并评估了局部皮质功能和皮质-皮质网络的组间差异。与健康对照组相比,PA和HIE均与频率特异性振幅降低有关。在两岁的PA儿童中,振幅相关网络在低频时更强,在高频时更弱,然而,两岁的HIE儿童在所有频率的连通性都有所下降。同样,PA患儿的相位相关网络在低频时更强,在高频时更弱。PA或HIE仅在少数皮质区域影响局部相幅耦合。我们的研究结果表明,即使没有临床HIE, PA也可能与局部皮质活动和大范围皮质网络的长期变化有关,这可能会影响正常的大脑功能。
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引用次数: 0
Lesion locations are associated with cognitive impairment after ischemic stroke in young adults 损伤部位与年轻人缺血性脑卒中后的认知损伤有关。
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103930
Mijntje M.I. Schellekens , Hao Li , Maartje Wijnands , Anastasia Papounidou , Esther M. Boot , Jamie I. Verhoeven , Merel S. Ekker , Mayte E. van Alebeek , Paul J.A.M. Brouwers , Renate M. Arntz , Gert W. van Dijk , Rob A.R. Gons , Inge W.M. van Uden , Tom den Heijer , Julia H. van Tuijl , Karlijn F. de Laat , Anouk G.W. van Norden , Sarah E. Vermeer , Marian S.G. van Zagten , Robert J. van Oostenbrugge , Anil M. Tuladhar

Introduction

Stroke location is an important determinant of post-stroke cognitive impairment (PSCI). In young adults, a comprehensive map of lesion patterns and their relations to PSCI is lacking. This study aims to identify lesion locations associated with poorer cognitive performance in patients with stroke at a young age.

Methods

We conducted a multicenter prospective cohort study between 2013 and 2021, enrolling patients aged 18–49 years with first-ever ischemic stroke and a visible stroke lesion on MRI. Cognitive assessments were performed within six months post-stroke, covering seven domains. We categorized patients as having no/mild or major vascular cognitive disorder (VCD), defined as a Z-score < -2.0 in one or more domains. We assessed aphasia by the NIHSS language subscale. We performed multivariate lesion-symptom mapping to identify lesion locations associated with major VCD, poorer cognitive performance in each domain, and aphasia.

Results

Among 522 patients (median age 44.3 years [IQR 37.7–41.5]; 257 [49.2 %] women), 168 (32.2 %) had major VCD. Lesions in both hemispheres and cerebellar regions were associated with presence of a major VCD, and lower performance in episodic memory, processing speed, executive functioning, language, and attention and working memory. Aphasia had the strongest relationship with left fronto-temporo-parietal regions, while the left angular gyrus was the region most associated with major VCD.

Discussion

We show that lesion locations associated with poorer cognitive performance in young stroke patients are widely distributed, including cerebellar regions. This study showcases the complexity in the relationships between affected brain regions and cognitive symptoms, explaining the variability in post-stroke cognitive outcome.
脑卒中位置是脑卒中后认知障碍(PSCI)的重要决定因素。在年轻人中,缺乏病变模式及其与PSCI关系的全面地图。本研究旨在确定与年轻中风患者认知能力下降相关的病变部位。方法:我们在2013年至2021年间进行了一项多中心前瞻性队列研究,招募了18-49岁的首次缺血性卒中且MRI上可见卒中病变的患者。中风后六个月内进行认知评估,涵盖七个领域。结果:522例患者(中位年龄44.3岁[IQR 37.7-41.5]; 257例[49.2%]女性)中,168例(32.2%)有严重血管性认知障碍(VCD)。大脑半球和小脑区域的病变与主要VCD的存在、情节记忆、处理速度、执行功能、语言、注意力和工作记忆的较低表现有关。失语症与左侧额颞顶叶区关系最密切,而左侧角回是与VCD主要相关的区域。讨论:我们发现与年轻脑卒中患者较差认知能力相关的病变部位分布广泛,包括小脑区。这项研究展示了受影响的大脑区域和认知症状之间关系的复杂性,解释了中风后认知结果的可变性。
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引用次数: 0
Fronto-limbic disconnection correlates with paroxysmal sympathetic hyperactivity following traumatic brain injury: An indirect disconnection-symptom mapping study 外伤性脑损伤后额缘断连与阵发性交感神经亢进相关:一项间接断连-症状映射研究。
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103937
Eric W Moffet , Sancharee Hom Chowdhury , Ediel Almeida , Xiangxiang Kong , Lujie Chen , Jiachen Zhuo , Nicholas A Morris , Gunjan Y Parikh , Neeraj Badjatia , Jamie E Podell
Paroxysmal sympathetic hyperactivity (PSH) is a clinically important manifestation of dysautonomia following traumatic brain injury (TBI). While it is thought to arise from central autonomic network disconnection, supporting evidence is limited. Here, we integrate clinically obtained magnetic resonance imaging (MRI) lesion data with human connectome data to identify specific white matter tract disconnections and gray matter parcel damage associated with PSH. Our sample included 117 patients who underwent susceptibility weighted imaging and 3D T1 MRI sequences as part of clinical care while admitted at our institution between January 1, 2016 and July 1, 2018. Susceptibility lesion masks were manually created and registered to standard template space. High quality registrations were obtained in 96 patients (50% with PSH), who were included in the study. Using the Matlab Lesion Quantification Toolkit, we assessed white matter tract disconnection severity and gray matter parcel damage for each patient. We compared results according to a binary PSH clinical diagnosis using Wilcoxon rank sum tests and a standard ordinal PSH diagnostic likelihood score (with 0–11 range) using Pearson correlations, Bonferroni-corrected for multiple comparisons. PSH diagnosis was associated with greater disconnection severity in nine tracts, two of which also correlated with higher diagnosis likelihood: the right uncinate fasciculus and the anterior corpus callosum. Damaged parcels associated with PSH included left prefrontal regions of the default mode network and the ventral salience network. In summary, our work implicates disconnection of fronto-limbic components of the central autonomic network in the pathophysiology of TBI-related PSH.
阵发性交感神经亢进(PSH)是外伤性脑损伤(TBI)后自主神经异常的重要临床表现。虽然它被认为是由中枢自主神经网络断开引起的,但支持证据有限。在这里,我们将临床获得的磁共振成像(MRI)病变数据与人类连接组数据相结合,以识别与PSH相关的特定白质束断开和灰质包裹损伤。我们的样本包括117名患者,他们在2016年1月1日至2018年7月1日期间在我们机构入院,接受了易感加权成像和3D T1 MRI序列作为临床护理的一部分。手动创建敏感性病变遮罩并注册到标准模板空间。96例患者(50%为PSH)纳入研究,获得了高质量的登记。使用Matlab病变量化工具包,我们评估了每位患者的白质束断开严重程度和灰质包裹损伤。我们根据使用Wilcoxon秩和检验的二值PSH临床诊断结果和使用Pearson相关性的标准有序PSH诊断似然评分(范围为0-11),对多重比较进行bonferroni校正。PSH诊断与9束更严重的断开程度相关,其中2束也与更高的诊断可能性相关:右钩扣束和前胼胝体。与PSH相关的受损包包括默认模式网络的左前额叶区域和腹侧突出网络。综上所述,我们的工作暗示了在tbi相关PSH的病理生理中,中枢自主神经网络的额边缘部分的断开。
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引用次数: 0
Association of MRI indexes of glymphatic system with brain atrophy and cognitive impairment in cerebral small vessel disease 脑小血管病脑萎缩和认知障碍与淋巴系统MRI指标的关系。
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2026.103951
Lulu Ai , Zhiwei Li , Chaojuan Huang , Xia Zhou , Xiaoqun Zhu , Qiaoqiao Xu , Zhongwu Sun

Background and objective

The glymphatic system constitutes a brain-wide perivascular network responsible for brain metabolic waste removal, which may underlie pathogenesis in cerebral small vessel disease (CSVD). This study aimed to explore the associations of glymphatic function, assessed using multi-modal MRI indices, and both brain atrophy and cognitive impairment in CSVD.

Methods

The study included 160 participants comprising 120 patients with CSVD, including 52 without cognitive impairment (CSVD-NCI) and 68 with mild cognitive impairment (CSVD-MCI), alongside 40 healthy controls (HCs). All participants underwent neuropsychological and multi-modal neuroimaging assessments. Glymphatic function was assessed using four complementary MRI indices: choroid plexus (CP) volume, perivascular space (PVS) volume fraction, free water in white matter (FW-WM) fraction, and diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. Gray matter volume (GMV) was evaluated via voxel-based morphology (VBM) analysis. Partial correlation and mediation analyses explored the relationships among glymphatic function, brain structure and cognitive performance.

Results

Compared to HCs, CSVD-MCI patients showed increased CP volume, FW-WM fraction, BG/putamen-PVS volume, and reduced DTI-ALPS index, accompanied by multifocal gray matter atrophy involving temporal and frontal regions. Advanced age was associated with increased CP and BG-PVS volume, but decreased DTI-ALPS index. A main effect of sex was observed, where males exhibited larger BG-PVS and FW-WM fraction, with lower DTI-ALPS index compared to females. Impaired glymphatic function was linked to both GMV loss and cognitive deficits, with right superior temporal and left postcentral GMV mediating glymphatic-cognitive associations, particularly in executive function and processing speed.

Conclusion

Glymphatic dysfunction in CSVD, particularly in cognitive impairment stage, is closely related to brain atrophy and cognitive decline, supporting the potential utility of glymphatic metrics as clinically imaging biomarkers for assessing cognitive impairment risk and monitor disease progression in CSVD.
背景与目的:淋巴系统构成了一个全脑范围的血管周围网络,负责脑代谢废物的清除,这可能是脑小血管病(CSVD)发病机制的基础。本研究旨在探讨用多模态MRI指数评估的淋巴功能与CSVD脑萎缩和认知障碍之间的关系。方法:该研究纳入160名参与者,包括120名CSVD患者,其中52名无认知障碍(CSVD- nci), 68名轻度认知障碍(CSVD- mci),以及40名健康对照(hc)。所有参与者都接受了神经心理学和多模态神经影像学评估。采用四个互补的MRI指标:脉络膜丛(CP)体积、血管周围空间(PVS)体积分数、白质游离水(FW-WM)分数和沿血管周围空间扩散张量图像分析(DTI-ALPS)指数来评估淋巴功能。通过基于体素的形态学(VBM)分析评估灰质体积(GMV)。部分相关分析和中介分析探讨了淋巴功能、脑结构和认知表现之间的关系。结果:与hc相比,CSVD-MCI患者CP体积、FW-WM分数、BG/壳核- pv体积增加,DTI-ALPS指数降低,伴颞额区多灶性灰质萎缩。高龄与CP和bg - pv体积增加有关,但与DTI-ALPS指数下降有关。观察到性别的主要影响,男性表现出较大的BG-PVS和FW-WM分数,与女性相比,DTI-ALPS指数较低。glymatic功能受损与GMV丧失和认知缺陷有关,右侧颞上和左侧后中枢GMV介导glymatic -认知关联,特别是在执行功能和处理速度方面。结论:CSVD的类淋巴功能障碍,特别是认知功能障碍阶段,与脑萎缩和认知能力下降密切相关,支持类淋巴指标作为评估认知功能障碍风险和监测CSVD疾病进展的临床成像生物标志物的潜在效用。
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引用次数: 0
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01
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引用次数: 0
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01
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引用次数: 0
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01
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引用次数: 0
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01
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引用次数: 0
Towards precision functional brain network mapping in Parkinson’s disease 帕金森氏病脑功能网络精确定位的研究。
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103935
Jacob Chernicky , Ally Dworetsky , Sarah Grossen , Emma Carr , Abdulmunaim Eid , Meghan C. Campbell , Caterina Gratton

Background

Parkinson’s disease (PD) is a complex neurodegenerative condition that leads to widespread disruption of large-scale brain networks and is further complicated by substantial individual variability in symptomology, progression rates, and treatment response. Consequently, the investigation of individual differences in networks measured via resting state functional connectivity (RSFC) may provide insight. However, most RSFC studies are unable to identify interindividual differences due to poor reliability and group average network definitions. “Precision” RSFC addresses these shortcomings through extended data collection, strict denoising, and individual network definition, but remains untested in PD.

Objectives

To evaluate the feasibility and reliability of precision RSFC studies in PD.

Methods

We collected > 100 min of RSFC data from 20 PD and 10 healthy control participants. We evaluated the level of motion, reliability and stability of RSFC measures in each participant, as well as compared to a conventional 5 min of RSFC data. These measures were benchmarked against HC to evaluate comparability. In addition, we created individualized brain network measures in PD participants to establish feasibility in this population.

Results

Using precision RSFC methods, the PD group produced reliable and stable measures of brain networks that were comparable in quality to healthy controls and substantially exceeded those derived from conventional approaches (whole-brain reliability: 5 min. r = 0.60 ± 0.06, 40 min. r = 0.88 ± 0.04; within-person stability: 5 min. r = 0.40 ± 0.08, 25 min. r = 0.68 ± 0.07; ps < 0.001). Individualized network maps in people with PD captured variation both from group-averaged templates and between individuals, including within motor-related networks.

Conclusion

Precision RSFC is feasible and reliable in individuals with PD. This approach holds promise for advancing personalized diagnostics and identifying brain-based biomarkers underlying clinical variability in PD.
背景:帕金森病(PD)是一种复杂的神经退行性疾病,可导致大范围脑网络的广泛破坏,并因症状、进展率和治疗反应的个体差异而进一步复杂化。因此,通过静息状态功能连接(RSFC)测量的网络个体差异的调查可能提供见解。然而,由于可靠性差和群体平均网络定义,大多数RSFC研究无法识别个体间差异。“精确”RSFC通过扩展数据收集、严格去噪和单独的网络定义来解决这些缺点,但在PD中尚未经过测试。目的:评价精确RSFC研究PD的可行性和可靠性。方法:收集20名PD患者和10名健康对照者的bbb100 min RSFC数据。我们评估了每位参与者的运动水平、RSFC测量的可靠性和稳定性,并与常规的5分钟RSFC数据进行了比较。这些措施以HC为基准来评估可比性。此外,我们在PD参与者中创建了个性化的脑网络测量,以确定在该人群中的可行性。结果:使用精确RSFC方法,PD组产生了可靠和稳定的脑网络测量,其质量与健康对照组相当,大大超过了传统方法(全脑可靠性:5分钟r = 0.60±0.06,40分钟r = 0.88±0.04;人内稳定性:5分钟r = 0.40±0.08,25分钟r = 0.68±0.07;ps结论:精确RSFC在PD患者中是可行和可靠的。这种方法有望推进个性化诊断和识别PD临床变异性的基于大脑的生物标志物。
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引用次数: 0
Neuroimaging correlates of symptom burden and functional recovery following mild traumatic brain injury: A systematic review 轻度外伤性脑损伤后症状负担和功能恢复的神经影像学相关性:系统综述。
IF 3.6 2区 医学 Q2 NEUROIMAGING Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103910
Joshua P. McGeown , Mangor Pedersen , Remika Mito , Alice Theadom , Jerome J. Maller , Paul Condron , Samantha J. Holdsworth

Background

Mild traumatic brain injury (mTBI) represents 95% of all traumatic brain injuries. Despite being classified as “mild,” mTBI can lead to persistent symptoms that impact quality of life. Diagnostic and management strategies rely heavily on subjective symptom reporting due to a lack of validated biomarkers. Identifying neuroimaging biomarkers to characterise the pathophysiological features underlying symptom burden and poor recovery is critical for improving mTBI management.

Objective

To synthesise evidence on cross-sectional, longitudinal, and prognostic links between Magnetic Resonance Imaging (MRI) features and mTBI symptom burden and functional recovery.

Methods

The review followed PRISMA guidelines. Systematic searches of MEDLINE, SCOPUS, and Cochrane Library identified mTBI studies with acute MRI data, measures of symptom burden or functional recovery, and at least one follow-up clinical timepoint, covering publications to July 18, 2025. Risk of bias was evaluated using the Quality in Prognostic Studies tool, and findings were synthesised narratively.

Results

Sixty-two of 7,232 articles were included. The review identified heterogeneous evidence across MRI modalities. Structural MRI findings showed limited correlation with clinical outcomes, while changes in white matter and functional connectivity were more strongly associated with symptom burden and recovery. Disruptions of integrative regions and association pathways such as the thalamus, superior longitudinal fasciculus, and cingulate cortex were linked to worse symptom burden and recovery outcomes.

Conclusions

Acute MRI, when contextualised with clinical data, helps delineate correlates of mTBI symptom burden and functional recovery. To strengthen inference, future neuroimaging studies should prespecify and report symptom burden and functional recovery as core endpoints.
背景:轻度创伤性脑损伤(mTBI)占所有创伤性脑损伤的95%。尽管mTBI被归类为“轻度”,但它会导致持续的症状,影响生活质量。由于缺乏有效的生物标志物,诊断和管理策略严重依赖主观症状报告。识别神经成像生物标志物,以表征症状负担和恢复不良的病理生理特征,对于改善mTBI管理至关重要。目的:综合磁共振成像(MRI)特征与mTBI症状负担和功能恢复之间的横断面、纵向和预后联系的证据。方法:按照PRISMA指南进行综述。对MEDLINE、SCOPUS和Cochrane图书馆的系统检索发现,mTBI研究具有急性MRI数据,症状负担或功能恢复的测量,以及至少一个随访临床时间点,涵盖出版物至2025年7月18日。使用预后研究质量工具评估偏倚风险,并对研究结果进行叙述性综合。结果:共纳入7232篇文献62篇。该综述确定了不同MRI模式的异质性证据。结构MRI结果显示与临床结果的相关性有限,而白质和功能连通性的变化与症状负担和恢复的相关性更强。丘脑、上纵束和扣带皮层等综合区域和关联通路的破坏与更严重的症状负担和恢复结果有关。结论:急性MRI与临床数据相结合,有助于描述mTBI症状负担和功能恢复的相关性。为了加强推理,未来的神经影像学研究应预先指定和报告症状负担和功能恢复作为核心终点。
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引用次数: 0
期刊
Neuroimage-Clinical
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