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The associations between positive body image, well-being and psychological flexibility in breast cancer survivors. 乳腺癌幸存者积极的身体形象、幸福感和心理灵活性之间的关联。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-10-16 DOI: 10.1080/13548506.2024.2417441
Giulia Rosa Policardo, Amanda Nerini, Cristian Di Gesto, Camilla Matera

In Italy, breast cancer survivors are increasing. Body image is a complex posttreatment concern for breast cancer survivors, particularly younger women. This population reports higher levels of body-image concerns associated with higher psychological distress and lower quality of life. Body image concerns and factors that can impact the body image of older breast cancer survivors remain an important but under-explored research area. The purpose of this study is to examine the association of negative and positive body image with both well-being and psychological inflexibility in a sample of breast cancer survivors. 114 women who have completed breast cancer treatment (±5 years) completed a questionnaire to measure the research variables. Hierarchical regressions and indirect effects were performed. Functionality appreciation and body compassion accounted for a significant percentage of the variance of well-being (34%) and psychological inflexibility (50%) of the participants. The indirect effect of body dissatisfaction on well-being and psychological inflexibility through body compassion was significant. The results emphasise the relevance of the positive aspect of body image on well-being and psychological inflexibility. Functionality appreciation and body compassion contribute to understanding the health-status description of these women and could be considered in future health-promotion interventions aimed at reducing psychological distress associated with body image concerns in older breast cancer survivors.

在意大利,乳腺癌幸存者越来越多。对于乳腺癌幸存者,尤其是年轻女性来说,身体形象是治疗后的一个复杂问题。据报告,这一人群对身体形象的关注程度较高,并伴有较高的心理压力和较低的生活质量。身体形象问题以及可能影响老年乳腺癌幸存者身体形象的因素仍然是一个重要的研究领域,但尚未得到充分探索。本研究的目的是在乳腺癌幸存者样本中研究消极和积极的身体形象与幸福感和心理僵化的关系。114 名已完成乳腺癌治疗(±5 年)的妇女填写了一份调查问卷,以测量研究变量。研究进行了层次回归和间接效应分析。在参与者的幸福感(34%)和心理不灵活(50%)的变异中,功能欣赏和身体同情占了很大比例。身体不满意通过身体同情对幸福感和心理不灵活的间接影响是显著的。研究结果强调了身体形象的积极方面对幸福感和心理灵活性的影响。功能欣赏和身体同情有助于了解这些妇女的健康状况描述,可在未来的健康促进干预中加以考虑,以减少老年乳腺癌幸存者与身体形象问题相关的心理困扰。
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引用次数: 0
The association between caregiver burden, social capital, and family functioning among caregivers of older adults with PSD - A cross-sectional study. 患有 PSD 的老年人的照顾者的照顾负担、社会资本和家庭功能之间的关系 - 一项横断面研究。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-10-21 DOI: 10.1080/13548506.2024.2411064
Hong Ni, Yang Liu, Jinqiu Yang, Huiying Qin, Yuru Hu, Huili Deng, Qu Shen

This study aimed to explore the relationships between social capital, family functioning, and caregiver burden in caregivers of older adults with post-stroke dementia (PSD). A cross-sectional correlational study was conducted between November 2017 and April 2018 among 105 caregivers of older adults with PSD using a demographic questionnaire, the Social Capital Scale, Family APGAR Index (APGAR), and Caregiver Burden Inventory (CBI).An independent samples t-test was also utilized to compare caregiver burden based on demographic characteristics. Statistical analysis comprised Pearson correlation analysis and multiple regression analysis using SPSS version 22.0 to identify influencing factors. Significant negative correlations were found between caregiver burden and variables such as social capital (p < .001) and family functioning (p < .01). The results of the multivariate analysis revealed that social capital, physical condition, and duration of caregiving were the main influencing factors (β = 58.162, ΔR2 = 0.289, p < .001). These findings suggest that nurses should continue to prioritize the well-being of patients' families, and collaborative efforts should be made to establish care facilities that cater to both medical and social needs.

本研究旨在探讨卒中后痴呆(PSD)老年人护理者的社会资本、家庭功能和护理者负担之间的关系。2017年11月至2018年4月期间,研究人员使用人口统计学问卷、社会资本量表、家庭APGAR指数(APGAR)和照护者负担量表(CBI)对105名PSD老年人的照护者进行了横断面相关性研究,并利用独立样本t检验比较了基于人口统计学特征的照护者负担。统计分析包括使用 SPSS 22.0 版进行的皮尔逊相关分析和多元回归分析,以确定影响因素。研究发现,照顾者负担与社会资本等变量之间存在显著的负相关(p p p
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引用次数: 0
Sleep actigraphy results and HIV health outcomes in an urban HIV clinic sample. 城市 HIV 诊所样本的睡眠动图结果和 HIV 健康结果。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-09-21 DOI: 10.1080/13548506.2024.2407444
Juan A Esquivel-Mendoza, Brooke G Rogers, Steven A Safren

Sleep disorders are prevalent and interfering conditions that affect people living with HIV (PLWH) at higher rates than the general population. Lower quality sleep has been associated with poorer health-related quality of life and immune function in PWH, though sleep is typically assessed subjectively. The current study aimed to examine the association between objective sleep/wake patterns measured via actigraphy with HIV outcomes. Participants (N = 87) were recruited from a public, urban HIV clinic located in the Southeastern United States. Participants were instructed to wear actigraphy monitors for one week (Range: 5-8 days). Log viral load and absolute CD4 were obtained via medical chart review. Linear regression analyses predicting HIV RNA Viral Load (log transformed) and CD4 Count were employed with three actigraphy sleep variables: sleep efficiency, wake after sleep onset (WASO), and sleep quantity. Backward entry regression with both significant actigraphy predictors, sleep efficiency and WASO, included as predictors resulted in sleep efficiency remaining in the model and WASO being removed. Separate models revealed that each one-unit increase in sleep efficiency was associated with a b = 0.032-point decrease in the log-transformed HIV RNA viral load (p = 0.03) and for each one-unit increase in wake after sleep onset (WASO) was associated with a b = 0.35-point increase in the log-transformed HIV RNA viral load (p = 0.04). Sleep quantity, however, was not, and none were associated with absolute CD4 count. The findings add to the evidence for an association of objectively measured poorer sleep efficiency being associated with higher HIV RNA viral load. Implications for clinical practice include assessing and addressing sleep efficiency as part of comprehensive clinical HIV care.

睡眠障碍是影响艾滋病病毒感染者(PLWH)的普遍和干扰性疾病,其发病率高于普通人群。较低的睡眠质量与艾滋病感染者较差的健康相关生活质量和免疫功能有关,尽管睡眠通常是主观评估的。本研究旨在探讨通过动图测量的客观睡眠/觉醒模式与艾滋病结果之间的关联。研究人员(N = 87)从美国东南部的一家公共城市艾滋病诊所招募。参与者被要求佩戴行动监测仪一周(范围:5-8 天)。对数病毒载量和绝对 CD4 通过病历审查获得。预测 HIV RNA 病毒载量(对数转换)和 CD4 计数的线性回归分析采用了三个动态影像睡眠变量:睡眠效率、睡眠开始后唤醒(WASO)和睡眠量。将睡眠效率和 WASO 这两个重要的动图预测因子作为预测因子进行后向输入回归,结果是睡眠效率保留在模型中,而 WASO 被移除。单独的模型显示,睡眠效率每增加一个单位,对数转换后的 HIV RNA 病毒载量就会减少 b = 0.032 个点(p = 0.03),而睡眠开始后觉醒(WASO)每增加一个单位,对数转换后的 HIV RNA 病毒载量就会增加 b = 0.35 个点(p = 0.04)。然而,睡眠量与CD4绝对计数无关。这些研究结果进一步证明,客观测量的较差睡眠效率与较高的 HIV RNA 病毒载量有关。该研究对临床实践的启示包括将评估和解决睡眠效率问题作为艾滋病综合临床护理的一部分。
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引用次数: 0
Turkish adaptation of the fear of cancer scale: validity, measurement invariance and reliability study. 癌症恐惧量表的土耳其语改编版:有效性、测量不变性和可靠性研究。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-10-20 DOI: 10.1080/13548506.2024.2417114
Hasan Evcіmen, Metin Yildiz

The aim of this study was to evaluate the Turkish cultural and psychometric properties of the cancer fear scale developed by Feng et al. This methodological study was conducted between January and April 2024 with students from a university in eastern Turkey. Data were collected from two different sample groups (sample 1:350, sample 2:245). Personal information form and cancer fear scale were used. In the adaptation process of the scale, language validity, content validity, construct validity, and reliability were examined. Exploratory factor analysis, confirmatory factor analysis, measurement invariance and convergent-divergent validity were used to determine construct validity. Cronbach alpha internal consistency coefficient, test-retest and corrected item-total correlation were used for reliability. According to the results of exploratory factor analysis, it was determined that the fear of cancer scale had a two-factor structure with factor loadings between 0.58 and 0.70. As a result of the confirmatory factor analysis performed on the two-factor structure of the fear of cancer scale, it was determined that the model goodness-of-fit indices were acceptable and had an excellent fit. It has been determined that measurement invariance findings across genders support configural, metric and scalar invariance. The Cronbach alpha internal consistency coefficient of the fear of cancer scale was 0.93, and the corrected item total correlation values were between 0.45 and 0.73. The Turkish version of the fear of cancer scale was found to be a valid and reliable measurement tool.

本研究旨在对 Feng 等人开发的癌症恐惧量表的土耳其文化和心理测量特性进行评估。 本方法研究于 2024 年 1 月至 4 月间在土耳其东部一所大学的学生中进行。数据收集自两个不同的样本组(样本 1:350 和样本 2:245)。研究使用了个人信息表和癌症恐惧量表。在量表的调整过程中,对语言效度、内容效度、结构效度和信度进行了检验。采用探索性因子分析、确认性因子分析、测量不变性和收敛-发散效度来确定建构效度。信度采用了 Cronbach alpha 内部一致性系数、重测和校正的项目-总相关性。根据探索性因子分析的结果,确定癌症恐惧量表具有双因子结构,因子负荷在 0.58 和 0.70 之间。对 "癌症恐惧量表 "的双因素结构进行确认性因素分析的结果表明,模型的拟合优度指数是可以接受的,具有很好的拟合效果。不同性别间的测量不变性结果支持构型不变性、度量不变性和标度不变性。癌症恐惧量表的 Cronbach alpha 内部一致性系数为 0.93,校正后的项目总相关值介于 0.45 和 0.73 之间。研究发现,土耳其版癌症恐惧量表是一种有效、可靠的测量工具。
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引用次数: 0
Assessment of quality of life, pain, depression, and body-image in breast cancer patients in neoadjuvant therapy. 对接受新辅助治疗的乳腺癌患者的生活质量、疼痛、抑郁和身体形象进行评估。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-11-20 DOI: 10.1080/13548506.2024.2422113
Ariane Vieira Carvalho, Vanessa Fernanda Lima Barroso, Cyntia Cristina Lobo Baeta, Aleida Nazareth Soares, Ana Paula Drummond-Lage

Breast cancer is the leading cancer type among women globally, and its chemotherapy often results in multiple side effects, compromising the patient's quality of life. Our study aimed to analyze the impact of neoadjuvant chemotherapy on the quality of life in Brazilian women with breast cancer within the public health system. This research was a one-year, observational, longitudinal study, conducted at a charitable health facility, examining the effect of neoadjuvant chemotherapy on these women's quality of life. Sociodemographic and clinical data were extracted from medical records. Quality of life parameters were gauged using Portuguese-validated questionnaires: EORTC.QLQ - C30 version 3.0, EORTC.BR-23, Body Image Scale (BIS), BPI-SF pain scale, and Beck Depression Inventory (BDI). These tools were utilized at three intervals: before the start of systemic treatment, after three months (before initiating paclitaxel), and upon concluding neoadjuvant therapy. Qualitative variables were tested for normality using the Kolmogorov-Smirnov test. As the continuous variables referring to the questionnaires did not show normal distribution, non-parametric tests were used: Friedman tests for paired pairs, and Wilcoxon and Mann-Whitney tests for multiple comparisons. In all tests, the significance level adopted was 5%. The software used for the analysis was SPSS. Our findings revealed a decline in quality of life, observing deterioration in the role, social, and cognitive functioning domains. Additionally, symptoms like fatigue, hyporexia, constipation, and diarrhea became more pronounced during the treatment. The presence of minimal depressive symptoms, associated with systemic therapy side effects also contributed to this worsening. Notably, there were no improvements in any quality of life-related parameters, and no discernible differences were observed in pain levels or body image across the evaluated periods.

乳腺癌是全球女性的主要癌症类型,其化疗往往会导致多种副作用,影响患者的生活质量。我们的研究旨在分析新辅助化疗对巴西公共卫生系统中乳腺癌女性患者生活质量的影响。这项研究是一项为期一年的观察性纵向研究,在一家慈善医疗机构进行,考察新辅助化疗对这些妇女生活质量的影响。研究人员从医疗记录中提取了社会人口学和临床数据。生活质量参数通过葡萄牙语验证的问卷进行测量:EORTC.QLQ - C30 3.0版、EORTC.BR-23、身体形象量表(BIS)、BPI-SF疼痛量表和贝克抑郁量表(BDI)。这些工具在三个时间间隔内使用:开始系统治疗前、三个月后(开始使用紫杉醇前)和结束新辅助治疗后。定性变量采用 Kolmogorov-Smirnov 检验法进行正态性检验。由于问卷中的连续变量不呈正态分布,因此采用了非参数检验:对配对变量进行弗里德曼检验,对多重比较变量进行 Wilcoxon 检验和 Mann-Whitney 检验。所有检验的显著性水平均为 5%。分析使用的软件是 SPSS。我们的研究结果表明,患者的生活质量有所下降,在角色、社交和认知功能方面均出现恶化。此外,在治疗期间,疲劳、厌食、便秘和腹泻等症状变得更加明显。与系统治疗副作用相关的轻微抑郁症状也是导致病情恶化的原因之一。值得注意的是,任何与生活质量相关的参数都没有得到改善,在整个评估期间也没有观察到疼痛程度或身体形象方面的明显差异。
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引用次数: 0
Active surveillance for prostate cancer is a shared journey: the dyadic perspective. 前列腺癌的积极监控是一段共同的旅程:从夫妇的角度看问题。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-09-29 DOI: 10.1080/13548506.2024.2407441
Stephanie Hughes, Hazel Everitt, Beth Stuart, Rebecca Band

Active surveillance for prostate cancer monitors disease progression, with a view to actively treat only if progression is evident. Living with an untreated cancer can negatively impact psychological wellbeing. Partners can influence decisions to convert to active treatment in the absence of disease progression, it is, therefore, important to consider partner reactions and responses to prostate cancer treatment options. We explored the experiences of men on active surveillance and their partners and the impact partner feelings, responses and reactions to active surveillance have on the patient. Semi-structured personal communication were conducted with nine male-female couples (n = 18). All male participants were on active surveillance for prostate cancer. Data was analysed using an adapted version of the Collaco et al. (2021) Framework Method for dyadic data analysis. Dyads function as an interconnected unit with interlinked emotional responses. Differing feelings about active surveillance within the couple were common; men prioritised avoidance of active treatment side effects, partners prioritised minimising the chance of disease progression. Partner inclusion is important, but they sometimes felt excluded by their partners and/or health care professionals. More support is needed for this population. Dyadic support is bidirectional and complex with partners often less comfortable with active surveillance than their partners. More research is needed to explore how partners can be better included and supported.

前列腺癌的主动监测可监控疾病的进展情况,只有在进展明显时才会积极治疗。癌症得不到治疗会对心理健康产生负面影响。伴侣可能会影响在疾病没有进展的情况下转为积极治疗的决定,因此,考虑伴侣对前列腺癌治疗方案的反应和回应非常重要。我们探讨了接受积极监控的男性及其伴侣的经历,以及伴侣的感受、反应和对积极监控的反应对患者的影响。我们与九对男女伴侣(n = 18)进行了半结构式个人交流。所有男性参与者都在接受前列腺癌的积极监测。数据分析采用 Collaco 等人(2021 年)框架方法的改编版进行。二元组作为一个相互联系的单元,具有相互关联的情感反应。夫妻双方对积极监控的不同感受很常见;男性优先考虑避免积极治疗的副作用,而伴侣则优先考虑将疾病进展的几率降至最低。伴侣的融入非常重要,但他们有时会感到被伴侣和/或医护人员排斥在外。需要为这类人群提供更多支持。双向支持是双向的,也是复杂的,伴侣往往比其伴侣更不愿意接受主动监测。需要开展更多的研究来探讨如何更好地包容和支持伴侣。
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引用次数: 0
Internet usage buffers the effect of loneliness on subjective health among informal caregivers of older adults. 使用互联网可缓冲孤独感对老年人非正式照顾者主观健康的影响。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-10-16 DOI: 10.1080/13548506.2024.2417313
Zhiya Hua

Informal caregivers of older adults usually suffer from loneliness, which makes them vulnerable to reduced health outcomes. This study attempted to explore whether internet usage mitigates the effects of loneliness on subjective health among informal caregivers of older adults. A sample of 1089 informal caregivers (mean age = 58.0 ± 15.7 years, 60.3% females) providing unpaid cares for older adults in the United States were investigated. Their loneliness, subjective health, and utilization of caregiving-related online resources were measured. Descriptive statistics and correlation analyses were conducted to summarize the sample's characteristics and determine the relationships among the study variables, respectively. Finally, a multivariate regression analysis with an interaction term was performed to test the moderating effect of internet usage. Results indicated that loneliness was significantly negatively associated with subjective health. Furthermore, after controlling for demographic and caregiving-related factors, the moderating effect of internet usage on the link between loneliness and subjective health was significant, namely, the negative association between loneliness and subjective health was less pronounced at higher levels of internet usage. Hence, in addition to alleviating loneliness, providing caregiving-related online services and promoting positive utilization of resources on the internet may be potential intervention targets to improve informal caregivers' health.

老年人的非正式照顾者通常会感到孤独,这使他们的健康状况很容易受到影响。本研究试图探讨互联网的使用是否能减轻孤独感对老年人非正式照顾者主观健康的影响。研究人员对美国为老年人提供无偿照顾的 1089 名非正式照顾者(平均年龄为 58.0 ± 15.7 岁,女性占 60.3%)进行了抽样调查。研究测量了他们的孤独感、主观健康状况以及对护理相关网络资源的利用情况。通过描述性统计和相关分析,分别总结了样本的特征,并确定了研究变量之间的关系。最后,进行了带有交互项的多元回归分析,以检验互联网使用的调节作用。结果表明,孤独感与主观健康呈显著负相关。此外,在控制了人口统计学和护理相关因素后,互联网使用对孤独感与主观健康之间联系的调节作用也很明显,即互联网使用水平越高,孤独感与主观健康之间的负相关越不明显。因此,除了缓解孤独感,提供与照顾者相关的在线服务和促进积极利用互联网资源也可能是改善非正规照顾者健康的潜在干预目标。
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引用次数: 0
Coping strategies associated with art adherence among older adults living with HIV, South Carolina. 与南卡罗来纳州感染艾滋病毒的老年人坚持艺术创作有关的应对策略。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-10-20 DOI: 10.1080/13548506.2024.2417314
Daniel A Amoatika, Prince N O Addo, Amandeep Kaur, Monique J Brown

People living with HIV/AIDS (PLWH) are living longer due to improvements in HIV care including antiretroviral therapy (ART). Even though ART improves HIV prognosis and life expectancy, its adherence is hindered by many factors. As the population of older adults living with HIV (OALH) continues to increase, it is important to understand the psychosocial factors that are associated with living with HIV to improve ART adherence. The aim of this study was to determine the association between coping strategies and ART adherence. Data were obtained from 91 OALH at an immunology clinic in Columbia, South Carolina via purposive sampling. The participants were at least 50 years or older and living with HIV. Coping was assessed using the Brief COPE Inventory. Crude and adjusted linear regression models, controlling for age, race, gender, and were used to determine the association between coping strategies and ART adherence. Subgroup analyses were done to determine if the association between coping and ART adherence varied by gender. The analyses were conducted in SAS version 9.4. The mean difference in ART adherence was statistically significant for race (p = 0.0292). There was a statistically significant association between religion and ART adherence (β = -0.718, p = 0.024). Males who use venting as a coping mechanism had higher ART adherence (β = 1.227, p = 0.048), and males who use behavioral disengagement had lower ART adherence (β = -1.624, p = 0.003) after adjusting for age and race. OALH who use religion as a coping strategy were less likely to adhere to ART treatment. Venting and behavioral disengagement tend to be associated with ART adherence among men. Qualitative research is needed to delve deeper into the relationship between religious coping and ART adherence, especially among OALH.

由于包括抗逆转录病毒疗法(ART)在内的艾滋病治疗手段的改进,艾滋病病毒感染者/艾滋病患者(PLWH)的寿命越来越长。尽管抗逆转录病毒疗法改善了艾滋病的预后和预期寿命,但许多因素却阻碍了患者坚持治疗。随着感染艾滋病病毒的老年人口(OALH)不断增加,了解与艾滋病病毒感染者相关的社会心理因素对于提高抗逆转录病毒疗法的依从性非常重要。本研究旨在确定应对策略与坚持抗逆转录病毒疗法之间的关系。研究人员通过有目的的抽样,从南卡罗来纳州哥伦比亚市一家免疫诊所的 91 名 OALH 中获得了数据。参与者年龄至少在 50 岁以上,并且是 HIV 感染者。应对能力采用简要 COPE 量表进行评估。在控制年龄、种族、性别等因素的基础上,使用粗线性回归模型和调整线性回归模型来确定应对策略与坚持抗逆转录病毒疗法之间的关系。为了确定应对策略与坚持抗逆转录病毒疗法之间的关系是否因性别而异,还进行了分组分析。分析在 SAS 9.4 版中进行。在种族方面,抗逆转录病毒疗法依从性的平均差异具有统计学意义(p = 0.0292)。宗教信仰与抗逆转录病毒疗法依从性之间的关系具有统计学意义(β = -0.718,p = 0.024)。使用发泄作为应对机制的男性抗逆转录病毒疗法依从性较高(β = 1.227,p = 0.048),而使用行为脱离作为应对机制的男性抗逆转录病毒疗法依从性较低(β = -1.624,p = 0.003)。使用宗教作为应对策略的 OALH 坚持抗逆转录病毒疗法的可能性较低。在男性中,发泄和行为脱离往往与坚持抗逆转录病毒疗法有关。需要进行定性研究,以深入探讨宗教应对策略与坚持抗逆转录病毒疗法之间的关系,尤其是在 OALH 中。
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引用次数: 0
Effects of personal cancer history and genomic risk information on mothers' psychological adaptation to inherited breast/ovarian cancer syndrome. 个人癌症史和基因组风险信息对母亲遗传性乳腺癌/卵巢癌综合征心理适应的影响。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-10-21 DOI: 10.1080/13548506.2024.2417311
Katharine S Chaillet, Marcelo M Sleiman, Mary Rose Yockel, Beth N Peshkin, Jessica J Chiang, Claudine Isaacs, Kenneth P Tercyak

This study aimed to understand long-term coping responses of mothers (N = 287) receiving genetic counseling and testing (GCT) for hereditary breast/ovarian cancer (HBOC) syndrome. Psychological characteristics, including cancer-specific distress (Impact of Events Scale-Revised, α = .85) and coping (Brief COPE, α = .93) were assessed via structured personal communication, along with epidemiologic items assessing personal and family history of cancer. Genetic risk was determined by BRCA1/2 carriage. A principal component analysis was conducted on the coping measure to reduce its summary score to active coping (α = .91) with nine approach-oriented strategies responsive to stress. A multivariable regression model examined the main and interacting effects of clinical and psychological characteristics on maternal coping. Personal cancer history (F = 4.99, df = 1, p = .026), BRCA test result (F = 22.20, df = 1, p < .001), and cancer-specific distress (F = 17.80, df = 1, p < .001) were associated with greater engagement in active coping strategies. When controlling for cancer-specific distress, the interaction between personal cancer history and genetic test results was significant, such that women previously unaffected by cancer who received positive BRCA results reported the greatest levels of active coping (F = 7.92, p < .001). These findings indicate that previous cancer history, genetic risk, and psychological distress independently and jointly impact how women adapt to the threat of cancer over time.

本研究旨在了解接受遗传性乳腺癌/卵巢癌(HBOC)综合征基因咨询和检测(GCT)的母亲(287 人)的长期应对反应。通过结构化的个人交流以及评估个人和家族癌症病史的流行病学项目对心理特征进行了评估,包括癌症特异性困扰(Impact of Events Scale-Revised, α = .85)和应对(Brief COPE, α = .93)。遗传风险根据 BRCA1/2 携带情况确定。对应对措施进行了主成分分析,将其总分降低为积极应对(α = .91),其中包括九种应对压力的方法策略。多变量回归模型检验了临床和心理特征对产妇应对方式的主要影响和交互影响。个人癌症病史(F = 4.99,df = 1,p = .026)、BRCA 检测结果(F = 22.20,df = 1,p p BRCA 结果报告的积极应对水平最高(F = 7.92,p = .026)。
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引用次数: 0
Facets of mindfulness are associated with inflammation biomarkers in a sample of sexual minority men with HIV. 正念的各个方面与感染艾滋病毒的性少数群体男性样本中的炎症生物标志物有关。
IF 2.3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 Epub Date: 2024-09-24 DOI: 10.1080/13548506.2024.2407445
Jacklyn Foley, Abigail W Batchelder, Lauren Bernier, Tiffany Glynn, Judith Moskowitz, Adam Carrico

Sexual minority men (SMM) are disproportionately impacted by HIV and thus, HIV related-health complications. HIV has been linked to earlier onset of multi-morbid chronic diseases and declines in physical and cognitive functioning attributable to chronic HIV immune activation and resulting inflammation. Inflammation has been targeted with mindfulness-based interventions (MBIs); however, hypothesized negative associations between mindfulness and inflammation need to be confirmed in SMM with HIV. This is a secondary data analysis of baseline data from a randomized clinical trial (RCT) of SMM living with HIV with biologically confirmed recent methamphetamine use (ARTEMIS). Mindfulness was assessed with the Five Factor Mindfulness Questionnaire (FFMQ). Inflammation was assessed via cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Separate adjusted (for age, viral load, CD4 count, and methamphetamine use) regression models evaluated associations between four facets of mindfulness (description, awareness, non-judgement, and non-reactivity) with IL-6 and TNF-α. The average age of the participants was 43.86 (SD = 8.95). Both description (b = .54, se = .24) and awareness (b = .50, se=.23) were positively associated with IL-6. All other associations between mindfulness and inflammation were non-significant in adjusted models. There was also some evidence to suggest that engagement in care moderated associations between description and non-reactivity with IL-6 (ΔR2 = .03, F = 3.64), such that description and non-reactivity were each positively associated with inflammation among those who attended <100% of primary care appointments (b = 1.04, se=.34 and b = 1.23, se=.39, respectively), but was not associated with inflammation among those who attended 100% of appointments (b =.16, se=.32 and b=-.17, se=.40, respectively). There was also a significant interaction between 12-step program attendance and awareness with IL-6 (ΔR2= .03, F = 4.26), such that awareness was positively associated with inflammation among those who attended 12-step programming (b = 1.25, se = .41), but not associated with inflammation among those who did not (b = .22, se = .28). Further research is needed to understand how and under what circumstances mindfulness is associated with pro- versus anti-inflammatory processes.Trial Registration: NCT01926184.

性少数群体男性(SMM)受到艾滋病毒的影响尤为严重,因此也受到与艾滋病毒相关的健康并发症的影响。艾滋病毒与多种慢性疾病的提早发病以及身体和认知功能的下降有关,这些都可归因于艾滋病毒的慢性免疫激活和由此导致的炎症。以正念为基础的干预措施(MBIs)已将炎症作为治疗目标;然而,正念与炎症之间的负相关假设需要在感染艾滋病毒的 SMM 中得到证实。本文是对一项随机临床试验(RCT)的基线数据进行的二次数据分析,研究对象是最近使用过甲基苯丙胺并经生物学证实的艾滋病病毒感染者(SMM)(ARTEMIS)。正念通过五因素正念问卷(FFMQ)进行评估。炎症通过细胞因子白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)进行评估。分别调整(年龄、病毒载量、CD4计数和甲基苯丙胺使用情况)回归模型评估了正念的四个方面(描述、意识、不判断和不反应)与IL-6和TNF-α之间的关系。参与者的平均年龄为 43.86 岁(SD = 8.95)。描述(b=.54,se=.24)和觉察(b=.50,se=.23)均与IL-6呈正相关。正念与炎症之间的所有其他关联在调整模型中均不显著。还有一些证据表明,参与护理调节了描述和非反应性与 IL-6 之间的关联(ΔR2 = .03, F = 3.64),例如,在参与护理的人群中,描述和非反应性分别与炎症呈正相关(b = 1.04, se=.34 和 b = 1.23, se=.39),但在 100%参与护理的人群中,描述和非反应性与炎症无关(分别为 b =.16, se=.32 和 b=-.17, se=.40)。参加 12 步计划与对 IL-6 的认识之间也存在明显的交互作用(ΔR2= 0.03,F = 4.26),因此参加 12 步计划的人对炎症的认识与炎症呈正相关(b = 1.25,se = 0.41),而未参加 12 步计划的人对炎症的认识与炎症无关(b = 0.22,se = 0.28)。要了解正念如何以及在何种情况下与促炎或抗炎过程相关,还需要进一步的研究:试验注册:NCT01926184。
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Psychology Health & Medicine
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