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Weight stigma in the dental setting: a qualitative exploration of the experiences of people living with obesity. 体重耻辱感在牙科设置:生活与肥胖的人的经验的定性探索。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-03 DOI: 10.1080/13548506.2026.2623304
Charlotte Banton, Heather Buchanan, Koula Asimakopoulou

People living with obesity (PLWO) are frequently subject to weight stigma in healthcare settings, which reduces their quality-of-care and exacerbates health inequalities. Evidence suggests PLWO also encounter weight stigma in the dental setting, however little research has explored this from the perspective of PLWO. This study aimed to explore the lived experiences of PLWO in the dental setting, specifically whether PLWO encounter weight stigma, receive patient-centred care, and whether (if so how) visiting the dentist can be improved for PLWO. In-depth semi-structured interviews were conducted with 12 PLWO; 10 females and 2 males ranging in age from 21 to 71 years. Interviews were audio-recorded, transcribed verbatim and analysed using inductive thematic analysis. Four overarching themes, (1) the dental setting as a safe space, (2) structural weight stigma setting, (3) stigmatising dentist-patient interactions, (4) weight stigma impacts on delivering patient-centred care, were generated. An equal number of participants had/had not encountered weight stigma in the dental setting. Weight stigma was perceived within direct dentist-patient interactions, the dental setting's physical environment and lack of access to bariatric dentistry, which seemed to impact upon the delivery of patient-centred care. Suggested avenues to improve visiting the dentist for PLWO included obesity education for the dental team. Participant lived experiences highlight that weight stigma is an issue some PLWO face in the dental setting. Professionals across clinical, educational and policy levels should work together to eliminate weight stigma in the dental setting and provide equitable care for PLWO.

肥胖患者在卫生保健机构中经常受到体重歧视,这降低了他们的保健质量,加剧了卫生不平等。有证据表明,PLWO在牙科环境中也会遇到体重耻辱感,但很少有研究从PLWO的角度探讨这一点。本研究旨在探讨PLWO在牙科环境中的生活经历,特别是PLWO是否遇到体重耻辱感,接受以患者为中心的护理,以及是否(如果有的话)就诊可以改善PLWO的牙医。对12名PLWO进行了深度半结构化访谈;10名女性和2名男性,年龄从21岁到71岁不等。访谈录音,逐字抄录,并采用归纳专题分析进行分析。产生了四个总体主题,(1)牙科设置作为一个安全空间,(2)结构重量污名设置,(3)污名化牙医与患者的互动,(4)体重污名化对提供以患者为中心的护理的影响。同等数量的参与者在牙科环境中有/没有遇到过体重耻辱感。在牙医与患者的直接互动、牙科环境的物理环境和缺乏获得减肥牙科的机会中,体重耻辱感被认为是存在的,这似乎影响了以患者为中心的护理的提供。建议改善PLWO就诊的途径包括对牙科团队进行肥胖教育。参与者的生活经验强调,体重耻辱感是一些PLWO在牙科环境中面临的问题。临床、教育和政策层面的专业人员应共同努力,消除牙科环境中的体重耻辱感,并为PLWO提供公平的护理。
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引用次数: 0
The relationship between pain and psychological resilience and perceived social support in liver cancer surgery cases. 肝癌手术患者疼痛与心理弹性及感知社会支持的关系。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-03 DOI: 10.1080/13548506.2026.2623310
Egemen ÇİÇek, Mustafa Kavak, Funda Kavak Budak, Tevfik Tolga Şahİn, Özgün Emre Akinci

The aim of this study is to determine the relationship between pain, psychological resilience, and perceived social support in liver cancer surgery cases. This is a descriptive and correlational study with a cross-sectional design. The research was conducted between May 2025 and August 2025 in the liver transplant unit and outpatient clinics of Y Medical Center, with a total of 45 patients. Data were collected using the Descriptive Characteristics Form, the Numeric Pain Rating Scale (NPRS), the Brief Resilience Scale (BRS), and the Multidimensional Scale of Perceived Social Support (MSPSS). For data analysis, independent samples t-test, analysis of variance (ANOVA), Pearson correlation analysis, and simple linear regression analysis were used. The study revealed a strong negative correlation between psychological resilience and pain levels (r = -0.842, p = 0.001), and a strong negative correlation between perceived social support and pain levels (r = -0.821, p = 0.002). In addition, a strong positive correlation was found between perceived social support and psychological resilience (r = 0.873, p = 0.001). Regression analysis indicated that perceived social support predicted 32% of the variance in pain levels and 42% of the variance in psychological resilience. The study found that as psychological resilience and perceived social support increased, pain levels decreased in liver cancer surgery cases. Furthermore, higher levels of perceived social support were associated with increased psychological resilience. Therefore, a holistic approach that includes not only physical but also psychological and social care should be adopted in the postoperative care process of these patients.

本研究旨在探讨肝癌手术患者的疼痛、心理弹性和感知社会支持之间的关系。这是一项横断面设计的描述性和相关性研究。该研究于2025年5月至2025年8月在Y医疗中心肝移植部和门诊进行,共有45名患者。采用描述性特征表、数字疼痛评定量表(NPRS)、简短恢复力量表(BRS)和感知社会支持多维量表(MSPSS)收集数据。数据分析采用独立样本t检验、方差分析(ANOVA)、Pearson相关分析和简单线性回归分析。研究发现心理弹性与疼痛水平呈显著负相关(r = -0.842, p = 0.001),感知社会支持与疼痛水平呈显著负相关(r = -0.821, p = 0.002)。此外,感知社会支持与心理弹性之间存在显著正相关(r = 0.873, p = 0.001)。回归分析表明,感知到的社会支持预测了32%的疼痛水平方差和42%的心理弹性方差。研究发现,随着心理弹性和感知到的社会支持的增加,肝癌手术患者的疼痛程度降低了。此外,更高水平的感知社会支持与心理弹性的增加有关。因此,在这些患者的术后护理过程中,不仅要采取身体护理,还要采取心理和社会护理的整体方法。
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引用次数: 0
How death reminders influence breast self-examination: testing the terror management health model among Chinese women. 死亡提醒对乳房自我检查的影响:对中国女性恐惧管理健康模式的检验。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-03 DOI: 10.1080/13548506.2026.2623305
Weijia Peng, Wenqing Zhang, Song Tong, Kaiping Peng

Death-related messaging is frequently used to promote preventive health behaviors, yet its psychological effects remain mixed and culturally dependent. Drawing on the Terror Management Health Model (TMHM), this study tested how mortality reminders influence breast self-examination (BSE) intentions in a Chinese cultural context, focusing on the moderating roles of individual traits and message framing. Across three experiments, we examined: (1) whether health optimism moderates the impact of mortality salience on BSE intention; (2) whether objectified imagery (e.g. lemons as metaphors) increases willingness more than biologized depictions under mortality salience; and (3) whether sociocultural value - oriented messages (e.g. celebrity-endorsed) sustain BSE intentions longer than health value - oriented ones. Mortality cues increased BSE willingness among women with high health optimism but reduced it among those with low optimism. Objectified representations enhanced short-term willingness more than anatomically framed ones. Health value messaging was more effective immediately post-exposure, while sociocultural framing better sustained intentions over time. Findings support TMHM's dual-defense framework and underscore the need to culturally adapt mortality-based health interventions. In the Chinese context - where body-related discourse remains sensitive - strategic message design and timing are critical to promoting preventive screening behaviors. These insights offer practical implications for designing culturally sensitive breast cancer campaigns that effectively motivate early screening behaviors.

与死亡有关的信息经常被用来促进预防性健康行为,但其心理影响仍然是混合的,并且取决于文化。基于恐惧管理健康模型(TMHM),本研究在中国文化背景下测试了死亡提醒如何影响乳房自我检查(BSE)意图,重点研究了个体特征和信息框架的调节作用。通过三个实验,我们检验了:(1)健康乐观是否会调节死亡显著性对疯牛病意向的影响;(2)在死亡显著性下,客观化意象(如柠檬)是否比生物化描绘更能增加意愿;(3)以社会文化价值为导向的信息(如名人认可)是否比以健康价值为导向的信息更能维持疯牛病的意图。死亡率线索增加了对健康高度乐观的女性患疯牛病的意愿,但降低了对健康不乐观的女性患疯牛病的意愿。客观表征比解剖学框架更能增强短期意愿。健康价值信息在接触后立即更有效,而社会文化框架则能随着时间的推移更好地维持意图。研究结果支持TMHM的双重防御框架,并强调需要在文化上适应基于死亡率的健康干预措施。在与身体相关的话语仍然敏感的中国背景下,策略信息设计和时机对于促进预防性筛查行为至关重要。这些见解为设计具有文化敏感性的乳腺癌活动提供了实际意义,这些活动可以有效地激励早期筛查行为。
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引用次数: 0
The relationship between childhood trauma and depressive symptoms: the serial mediation role of ruminative thinking and prospective imagery vividness. 儿童创伤与抑郁症状的关系:反刍思维和远景意象生动性的系列中介作用。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2025-06-24 DOI: 10.1080/13548506.2025.2519236
Li Zhou, Nuoling Yao, Zihui Zengxu, Biyun Wu, Mingfan Liu

Some studies have shown that childhood trauma may damage the cognitive function of patients with mood disorders, which is related to the increase of depression. Other studies highlighted that negative expectations for the future and excessive ruminant thinking have an impact on the maintenance or even exacerbation of depressive symptoms. The current study examined the serial mediating role of rumination and prospective imagery vividness between childhood trauma and depressive symptoms. A total of 1711 college students provided self-report data on the childhood trauma questionnaire, the prospective imagery task, ruminative responses scale and patient health questionnaire-9. Data showed that childhood trauma, ruminative thinking and vividness of prospective negative imagery were inversely related to depressive symptoms. The ruminative thinking and prospective negative imagery completely and serially mediated the relation between childhood trauma and depressive symptoms. Additionally, the ruminative thinking and vividness of prospective positive imagery completely and serially mediated the relation between childhood trauma and depressive symptoms. These results suggest that ruminative thinking and prospective imagery vividness exerted a serial mediating effect in the relationship between childhood trauma and depressive symptoms, increasing the risk of depression.

一些研究表明,童年创伤可能损害心境障碍患者的认知功能,这与抑郁症的增加有关。其他研究强调,对未来的负面预期和过度的反刍思维对抑郁症状的维持甚至恶化有影响。本研究考察了反刍和前瞻性意象生动性在儿童创伤与抑郁症状之间的系列中介作用。1711名大学生提供了童年创伤问卷、前瞻性想象任务、反刍反应量表和患者健康问卷的自述数据-9。数据显示,童年创伤、反刍思维和前瞻性负面意象的生动性与抑郁症状呈负相关。反刍思维和前瞻性消极意象在儿童创伤与抑郁症状的关系中起着完全、连续的中介作用。此外,反刍思维和前瞻性积极意象的生动性在童年创伤与抑郁症状之间的关系中起着完全和连续的中介作用。这些结果表明,反刍思维和前瞻性意象生动性在儿童创伤与抑郁症状的关系中发挥了一系列的中介作用,增加了抑郁的风险。
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引用次数: 0
Fear of childbirth and its influence on women's delivery choices: a prospective-longitudinal study. 对分娩的恐惧及其对女性分娩选择的影响:一项前瞻性纵向研究。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2025-02-11 DOI: 10.1080/13548506.2025.2465650
Xinchen Chen, Lu Jing, Huijing Liu, Sisi Huang, Liting Yan, Qiaoyu Jiang, Pingping Qiu

The fear of childbirth (FOC) is a widespread issue that affects the wellbeing of pregnant women. This study aimed to investigate the impact of FOC on the preferred and actual delivery mode of Chinese primiparous and multiparous women, by controlling for potential confounding factors using Lazarus's Theory of Stress, Emotion, and Coping. We conducted this perspective-longitudinal study included 1,288 pregnant women in late pregnancy in China. Data was collected through face-to-face questionnaires, cross-checking with electronic medical records, and the use of standardized measurement tools. The actual delivery mode was followed, and statistical analysis included univariate and multivariate regression analyses. Results showed that FOC had a positive association with preference for a cesarean section. However, neither FOC nor the preference for cesarean section resulted in higher cesarean section rates. Women who received childbirth education at hospitals had higher rates of vaginal delivery. This study highlights that FOC increases the likelihood of preferring a cesarean section, but it does not significantly impact the actual delivery mode. Further research is needed to explore the reasons behind the discrepancy between preferred and actual delivery modes and its implications.

分娩恐惧(FOC)是影响孕妇健康的一个普遍问题。本研究旨在利用拉扎勒斯的压力、情绪和应对理论(Theory of Stress, Emotion, and Coping),通过控制潜在的混杂因素,调查分娩恐惧对中国初产妇和多产妇首选和实际分娩方式的影响。我们进行了这项透视纵向研究,研究对象包括 1288 名中国孕晚期孕妇。我们通过面对面问卷调查、与电子病历核对以及使用标准化测量工具收集数据。统计分析包括单变量和多变量回归分析。结果显示,顺产与剖腹产的偏好呈正相关。然而,无论是方便分娩还是选择剖腹产,都不会导致剖腹产率升高。在医院接受分娩教育的妇女阴道分娩率较高。这项研究强调,方便分娩增加了选择剖腹产的可能性,但对实际分娩方式并无显著影响。需要进一步研究探讨首选分娩方式与实际分娩方式之间存在差异的原因及其影响。
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引用次数: 0
Post-event rumination as a mediator in the relationship between self-focused attention and social anxiety in Chinese adolescents. 事件后反刍在青少年自我集中注意与社交焦虑之间的中介作用。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2025-05-07 DOI: 10.1080/13548506.2025.2502845
Yuchi Zhang, Yueyi Huang, Runting Chen, Dingguo Gao, Meng Yu

Cognitive models of social anxiety disorder have conveyed the implication that self-focused attention (SFA) and post-event rumination (PER) are significant predictors in maintaining the symptoms of social anxiety (SA); however, their relationships have been scarcely studied in adolescents, including Chinese samples. The primary purpose of the current study was to examine the role of PER as a potential mediator between SFA and SA among Chinese adolescents; moreover, the moderation effect of gender was investigated. A total of 2,755 Chinese adolescents ranging in age from 11 to 19 years old with an average age of 14.18 were recruited from six urban public schools. Participants were asked to complete questionnaires measuring SFA, PER, SA, and depression. Structural equation modeling results showed that PER displayed as a plausible mediator in the relationship between SFA and SA, even after controlling for depression. In addition, gender was revealed to be a significant moderator, with a stronger relationship between PER and SA for girls than for boys. The current study provided evidence for Clark and Wells' proposition about the associations among SFA, PER, and SA, contributing to the field of adolescents' mental health and supporting the cultural applicability of the model.

社交焦虑障碍的认知模型表明,自我集中注意(SFA)和事后反刍(PER)是维持社交焦虑症状的显著预测因子;然而,他们之间的关系在青少年中几乎没有研究,包括中国的样本。本研究的主要目的是研究PER在中国青少年SFA和SA之间的潜在中介作用;此外,还考察了性别的调节作用。从六所城市公立学校共招募了2755名年龄在11岁至19岁之间的中国青少年,平均年龄为14.18岁。参与者被要求完成测量SFA、PER、SA和抑郁的问卷。结构方程模型结果显示,即使在控制抑郁后,PER在SFA和SA之间的关系中也表现出可能的中介作用。此外,性别是一个重要的调节因素,女孩的PER和SA之间的关系比男孩更强。本研究为Clark和Wells关于SFA、PER和SA之间关系的命题提供了证据,为青少年心理健康领域做出了贡献,并支持了该模型的文化适用性。
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引用次数: 0
Maternal life events, anxiety, social support, and prenatal depression among pregnant women: a cross-sectional study in Yinchuan, China. 银川市孕妇孕期生活事件、焦虑、社会支持与产前抑郁的横断面研究
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2025-04-24 DOI: 10.1080/13548506.2025.2496996
Li He, Mei Su, Li Bie, Yingchun Ha, Fangyuan Wu, Weidong Mu, Xiaoqin Ma

While the association between life events and depression has been well-established, the mechanisms linking life events to depression in pregnant women require further exploration. This study aimed to explore the association between maternal life events and depression, with anxiety and social support as potential influencing factors. A cross-sectional study was conducted from January 2020 to December 2021 among 1767 pregnant women recruited via convenience sampling from a tertiary hospital in Yinchuan, China. Participants completed the Patient Health Questionnaire-9 (PHQ-9), Life Events Scale for Pregnant Women (LESPW), Generalized Anxiety Disorder scale (GAD-7), and Social Support Rating Scale (SSRS). Data were analyzed using SPSS 26.0 and PROCESS 3.5. The key findings revealed that: maternal life events were positively associated with depression, with a total effect of 0.323 (95%CI = 0.283-0.363, p < 0.001) and a direct effect of 0.117 (95%CI = 0.084-0.151, p < 0.001). Anxiety partially mediated this association, accounting for 63.8% of the total effect (indirect effect = 0.206, 95%CI = 0.175-0.239, p < 0.001). Social support and its three dimensions negatively influenced the association between maternal life events and anxiety(moderating effects: overall social support β=-0.840, subjective support β=-0.786, objective support β=-0.360, support utilization β=-0.441, all p < 0.01). These findings suggest that maternal life events influence prenatal depression both directly and indirectly, while social support mitigates anxiety triggered by stressors. Targeted interventions to reduce life event exposure and strengthen social support may alleviate anxiety and depression in pregnant women.

虽然生活事件与抑郁症之间的联系已经确立,但将生活事件与孕妇抑郁症联系起来的机制还需要进一步探索。本研究旨在探讨母亲生活事件与抑郁的关系,并将焦虑和社会支持作为潜在的影响因素。本研究于2020年1月至2021年12月对银川市某三级医院的1767名孕妇进行了横断面研究。参与者完成了患者健康问卷-9 (PHQ-9)、孕妇生活事件量表(LESPW)、广泛性焦虑障碍量表(GAD-7)和社会支持评定量表(SSRS)。数据采用SPSS 26.0和PROCESS 3.5进行分析。主要结果显示:母亲生活事件与抑郁呈正相关,总效应为0.323 (95%CI = 0.283 ~ 0.363, p CI = 0.084 ~ 0.151, p CI = 0.175 ~ 0.239, p β=-0.840,主观支持β=-0.786,客观支持β=-0.360,支持利用β=-0.441,均为p
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引用次数: 0
The relationship between social media addiction, insomnia, and depression in adolescents. 青少年社交媒体成瘾、失眠和抑郁之间的关系。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2025-02-13 DOI: 10.1080/13548506.2025.2465659
Necmettin Çiftci, Abdullah Sarman, Mahmut Çoban

This study aims to investigate the relationship between social media addiction, insomnia, and depression in adolescents. This correlational-cross-sectional-descriptive study involved 780 adolescents (mean age: 15.11 ± 1.20; 50.5% female) from high schools in a city center in Eastern Turkey. Data were gathered using a personal information form and validated scales, including the Bergen Social Media Addiction Scale, Bergen Insomnia Scale, and 6-item Kutcher Depression Scale. Data analysis was performed using SPSS 25.0, AMOS V 24.0, and G*Power 3.1 statistical package programs. It was determined that the mean score of adolescents' social media addiction was 15.81 ± 5.50, the mean score of insomnia was 16.98 ± 10.84 and the mean score of depression was 7.30 ± 4.47. A significant positive relationship was observed between social media addiction and both insomnia and depression. Additionally, insomnia and depression were significantly correlated. Social media usage time was positively associated with higher levels of social media addiction, insomnia, and depression. Depression was found to mediate the relationship between social media addiction and insomnia. Pediatric and school health nurses are encouraged to assess adolescents' social media usage habits, including time spent online, and develop monitoring and intervention programs. These programs can provide immediate support to address social media-related psychological and behavioral issues effectively.

本研究旨在调查青少年社交媒体成瘾、失眠和抑郁之间的关系。这项相关性横断面描述性研究涉及土耳其东部某市中心高中的 780 名青少年(平均年龄:15.11 ± 1.20;50.5% 为女性)。研究使用个人信息表和经过验证的量表(包括卑尔根社交媒体成瘾量表、卑尔根失眠量表和 6 项库切尔抑郁量表)收集数据。数据分析采用 SPSS 25.0、AMOS V 24.0 和 G*Power 3.1 统计软件包程序进行。结果显示,青少年社交媒体成瘾的平均得分为(15.81 ± 5.50)分,失眠的平均得分为(16.98 ± 10.84)分,抑郁的平均得分为(7.30 ± 4.47)分。社交媒体成瘾与失眠和抑郁之间存在明显的正相关关系。此外,失眠和抑郁也呈显著正相关。社交媒体使用时间与较高程度的社交媒体成瘾、失眠和抑郁呈正相关。研究发现,抑郁是社交媒体成瘾与失眠之间关系的中介。我们鼓励儿科和学校保健护士评估青少年使用社交媒体的习惯,包括上网时间,并制定监控和干预计划。这些计划可以提供即时支持,有效解决与社交媒体相关的心理和行为问题。
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引用次数: 0
Are social supports associated with suicidal ideation based on gender differences among adolescents in Indonesia? 社会支持与印尼青少年自杀意念是否存在性别差异?
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2025-03-23 DOI: 10.1080/13548506.2025.2481623
Ayu Khoirotul Umaroh, Purwo Setiyo Nugroho

The proportion of Indonesian junior and senior high school students considering suicide was around 5.2% in 2015. This research analysed the association between social supports and suicidal ideation based on gender differences among adolescents in Indonesia.

Methods: This cross-sectional study analysed secondary data from the Global School-based Health Survey (GSHS). The 9,333 respondents were aged 11 to 18 years. The dependent variable was suicidal ideation in the past 12 months before the survey. The independent variables were peer support, parent support, and parent attention. The multivariable analysis applied the enter method to examine the adjusted effect causing the dependent variable.

Result: Boys had a higher risk than girls of considering suicide on all of the associated independent variables, including boys aged <15 years (AOR 6.134, 95% CI 4.342-8.665), boys in junior high school (AOR 3.160, 95% CI 2.205-4.528), boys with no peer support (AOR 4.230, 95% CI 2.996-5.972), boys with no parental support (AOR 2.481, 95% CI 1.686-3.650) and boys with no parental attention (AOR 3.268, 95% CI 2.292-4.658).

Conclusion: Boys with no peer support had a 4.230 times higher risk of suicidal ideation.

2015年,印尼初高中学生考虑自杀的比例约为5.2%。本研究基于性别差异分析印尼青少年社会支持与自杀意念之间的关系。方法:本横断面研究分析了来自全球学校健康调查(GSHS)的二手数据。9333名受访者年龄在11岁至18岁之间。因变量为调查前12个月内的自杀意念。自变量为同伴支持、父母支持和父母关注。多变量分析采用进入法对因变量的调整效果进行检验。结果:在所有相关的自变量中,男孩的自杀倾向风险高于女孩,包括男孩的年龄。结论:没有同伴支持的男孩的自杀意念风险是女孩的4.230倍。
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引用次数: 0
Correlation investigation between BDNF (Val66Met/rs6265) polymorphism and attention deficit hyperactivity disorder susceptibility in Chinese mainland population: a meta-analysis. 中国大陆人群BDNF(Val66Met/rs6265)多态性与注意缺陷多动障碍易感性的相关性研究:一项荟萃分析。
IF 1.9 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-01 Epub Date: 2024-11-21 DOI: 10.1080/13548506.2024.2430794
Yu Lu

This meta-analysis evaluated the association between the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) and the susceptibility to attention deficit hyperactivity disorder (ADHD) in the Chinese mainland population. Eligible documents were selected from online databases including PubMed, Embase, Cochrane Library, CNKI, Wanfang and CBM (updated to 15 October 2023). The evaluation of study quality was conducted according to guidelines of Newcastle-Ottawa Scale. Basic features of patients, OR and 95% CI were retrieved to assess the correlation between ADHD susceptibility and Val66Met polymorphism in four genetic models: allele genetic model (mutation (A) vs. wild-type (G)), additive genetic model (AA vs. GG and AG vs. GG), recessive genetic model (AA vs. AG+GG) and dominant genetic model (AA+AG vs. GG). This study included totally four studies for subsequent meta-analysis. The results indicated that the correlation between ADHD susceptibility and Val66Met polymorphism in A vs. G (OR = 0.8840, 95%CI: [0.6696-1.1672], p = 0.3846), AA vs. GG (OR = 0.8436, 95%CI: [0.5432-1.3102], p = 0.4490), AA+AG vs. GG (OR = 0.8602, 95%CI: [0.6497-1.1391], p = 0.2933), AG vs. GG (OR = 0.9132, 95%CI: [0.7810-1.0679], p = 0.2556) and AA vs. GG+AG (OR = 1.0315, 95%CI: [0.8789-1.2105], p = 0.7044) was not significant. Egger's test and sensitivity analysis demonstrating the reliability and stability our conclusions, respectively. BDNF Val66Met polymorphism did not contribute to the susceptibility of ADHD in Chinese mainland population.

本荟萃分析评估了中国大陆人群脑源性神经营养因子(BDNF)Val66Met多态性与注意力缺陷多动障碍(ADHD)易感性之间的关系。符合条件的文献选自在线数据库,包括PubMed、Embase、Cochrane Library、CNKI、万方和CBM(更新至2023年10月15日)。研究质量评估根据纽卡斯尔-渥太华量表指南进行。检索了患者的基本特征、OR 和 95% CI,以评估多动症易感性与 Val66Met 多态性在四种遗传模式中的相关性:等位基因遗传模式(突变 (A) vs. 野生型 (G))、加性遗传模式(AA vs. GG 和 AG vs. GG)、隐性遗传模式(AA vs. AG+GG)和显性遗传模式(AA+AG vs. GG)。本研究共纳入了四项研究进行荟萃分析。结果表明,多动症易感性与 Val66Met 多态性之间的相关性在 A vs. G(OR = 0.8840,95%CI: [0.6696-1.1672],p = 0.3846)、AA vs. GG(OR = 0.8436,95%CI: [0.5432-1.3102],p = 0.4490)、AA+AG vs. GG(OR = 0.8602,95%CI:[0.6497-1.1391],p = 0.2933)、AG vs. GG(OR = 0.9132,95%CI:[0.7810-1.0679],p = 0.2556)和 AA vs. GG+AG(OR = 1.0315,95%CI:[0.8789-1.2105],p = 0.7044)不显著。Egger 检验和敏感性分析分别证明了我们结论的可靠性和稳定性。BDNF Val66Met多态性与中国大陆人群多动症的易感性无关。
{"title":"Correlation investigation between BDNF (Val66Met/rs6265) polymorphism and attention deficit hyperactivity disorder susceptibility in Chinese mainland population: a meta-analysis.","authors":"Yu Lu","doi":"10.1080/13548506.2024.2430794","DOIUrl":"10.1080/13548506.2024.2430794","url":null,"abstract":"<p><p>This meta-analysis evaluated the association between the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) and the susceptibility to attention deficit hyperactivity disorder (ADHD) in the Chinese mainland population. Eligible documents were selected from online databases including PubMed, Embase, Cochrane Library, CNKI, Wanfang and CBM (updated to 15 October 2023). The evaluation of study quality was conducted according to guidelines of Newcastle-Ottawa Scale. Basic features of patients, OR and 95% CI were retrieved to assess the correlation between ADHD susceptibility and Val66Met polymorphism in four genetic models: allele genetic model (mutation (A) vs. wild-type (G)), additive genetic model (AA vs. GG and AG vs. GG), recessive genetic model (AA vs. AG+GG) and dominant genetic model (AA+AG vs. GG). This study included totally four studies for subsequent meta-analysis. The results indicated that the correlation between ADHD susceptibility and Val66Met polymorphism in A vs. G (OR = 0.8840, 95%CI: [0.6696-1.1672], <i>p</i> = 0.3846), AA vs. GG (OR = 0.8436, 95%CI: [0.5432-1.3102], <i>p</i> = 0.4490), AA+AG vs. GG (OR = 0.8602, 95%CI: [0.6497-1.1391], <i>p</i> = 0.2933), AG vs. GG (OR = 0.9132, 95%CI: [0.7810-1.0679], <i>p</i> = 0.2556) and AA vs. GG+AG (OR = 1.0315, 95%CI: [0.8789-1.2105], <i>p</i> = 0.7044) was not significant. Egger's test and sensitivity analysis demonstrating the reliability and stability our conclusions, respectively. BDNF Val66Met polymorphism did not contribute to the susceptibility of ADHD in Chinese mainland population.</p>","PeriodicalId":54535,"journal":{"name":"Psychology Health & Medicine","volume":" ","pages":"519-530"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Psychology Health & Medicine
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