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Adherence to Oral Nutritional Support and Its Effect on Nutritional Status in Pediatric Oncology Patients. 坚持口服营养支持及其对儿科肿瘤患者营养状况的影响。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-12-07 DOI: 10.1080/01635581.2025.2584473
Mehmet Kantar, Derya Hopancı Bıçaklı, Ayşe Özkan, İnci İlhan, Nurdan Taçyıldız, Rejin Kebudi, Nurşah Eker, Zuhal Siviş, Uğur Demirsoy, Bahar Beker, Şule Yeşil, Ali Varan, Bengü Demirağ, İbrahim Bayram, Derya Özyörük, Eda Ataseven, Sonay İncesoy, Sema Büyükkapu, Burcu Tufan, Deniz Kızmazoğlu, Sema Vural, Burçak Kurucu, Çağrı Coşkun, Alihan Sürsal, Emre Özkan, Fatih Özdener

Children with cancer frequently suffer from malnutrition caused by their disease and treatments. This study examines the rates of malnutrition, compliance with nutritional therapy, and its impact on nutritional status in pediatric cancer patients. This multicenter cross-sectional study was conducted between 2021 and 2023 at 12 pediatric hematology and oncology clinics. This study included 385 patients (aged 0.3-18 years) with leukemia-lymphoma and solid tumors that are currently on or had newly started oral nutritional supplement (ONS) treatment. Anthropometric measurements, mid-upper-arm-circumference (MUAC), body mass index (BMI), weight-for-age (WFA), were collected, and malnutrition risk was evaluated by the nutrition screening tool for childhood cancer (SCAN). Baseline WFA-based malnutrition was 31.0%, increasing to 38.5%, while SCAN≥3 was 83.8% decreasing to 72.4% at the sixth month. Malnutrition risk was more common in sarcoma and central nervous system tumor patients. ONS adherence decreased across all cancer types during the follow-up period. Adherent patients demonstrated higher BMI scores during the study period and MUAC z-scores in the last 2 months compared to the non-adherent group (P < 0.04). Our study demonstrates that the use of validated nutrition screening tools, together with adherence strategies, can lead to increased weight-for-age and lower malnutrition risk screening scores.

患有癌症的儿童往往因疾病和治疗而营养不良。本研究探讨儿童癌症患者的营养不良率、营养治疗依从性及其对营养状况的影响。这项多中心横断面研究于2021年至2023年在12家儿科血液学和肿瘤学诊所进行。这项研究包括385例(年龄0.3-18岁)患有白血病淋巴瘤和实体瘤的患者,这些患者目前正在或刚刚开始口服营养补充剂(ONS)治疗。收集人体测量数据、中上臂围(MUAC)、体重指数(BMI)、年龄体重(WFA),并通过儿童癌症营养筛查工具(SCAN)评估营养不良风险。基线wfa营养不良为31.0%,上升至38.5%,而SCAN≥3为83.8%,在第6个月下降至72.4%。营养不良风险在肉瘤和中枢神经系统肿瘤患者中更为常见。在随访期间,所有癌症类型的ONS依从性都有所下降。与非依从组相比,依从组患者在研究期间的BMI评分和最后2个月的MUAC z评分均较高(P
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引用次数: 0
Letter to the Editor: Revisiting the Impact of Obesity on Cancer-Specific Survival in Rectal Cancer-Clinical and Translational Implications. 致编辑的信:重新审视肥胖对直肠癌癌症特异性生存的影响——临床和转化意义。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1080/01635581.2025.2584453
Pengyu Han, Jin Zhang, Xingyu Zhou, Donghu Liu, Jin Zheng
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引用次数: 0
Letter to the Editor: Reevaluating Diet-microbiota Interactions in Colorectal Carcinogenesis. 致编辑的信:重新评估饮食-微生物群在结直肠癌发生中的相互作用。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-11-21 DOI: 10.1080/01635581.2025.2593434
Pınar Peker, Seher Selvi
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引用次数: 0
Vitamin K2 Supplementation and Clinical Outcomes in Hepatocellular Carcinoma Patients: A Meta-Analysis with Trial Sequential Analysis. 维生素K2补充和肝细胞癌患者的临床结果:一项试验序列分析的荟萃分析。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-12-13 DOI: 10.1080/01635581.2025.2600102
Francisco Cezar Aquino de Moraes, Vitor Kendi Tsuchiya Sano, Caroline R M Pereira, Jamile Cristine Marques Barros, Rommel Mario Rodríguez Burbano

Background and aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality globally. The potential benefits of vitamin K (VK) supplementation for patients with HCC remain unclear. This study aimed to evaluate the impact of VK supplementation on clinical outcomes in patients undergoing HCC treatment.

Methods: A systematic search across Medline, Scopus, and Web of Science databases identified relevant studies. Pooled odds ratios (OR) with 95% confidence intervals (CI) assessed treatment group differences in binary outcomes. Heterogeneity was evaluated using I2 statistics. Analyses were performed using R (version 4.2.3).

Results: Eleven studies encompassing 1,030 patients were included. VK supplementation significantly reduced disease recurrence (DR) compared to control at 1 year (OR 0.55, 95% CI 0.32-0.97; p = 0.039), 2 years (OR 0.52, 95% CI 0.35-0.77; p = 0.001), and 3 years (OR 0.41, 95% CI 0.25-0.67; p = 0.000). Additionally, VK supplementation significantly decreased mortality at 1 year (OR 0.20, 95% CI 0.07-0.60; p = 0.004), 2 years (OR 0.38, 95% CI 0.18-0.82; p = 0.014), and 3 years (OR 0.37, 95% CI 0.21-0.66; p = 0.001). Notably, no significant difference in adverse events was observed between VK and control groups (OR 3.56, 95% CI 0.06-198.66; p = 0.536).

Conclusion: This study suggests substantial benefits associated with VK supplementation in HCC patients, particularly in reducing DR and mortality across one, two, and three years. Importantly, these improvements were achieved without a significant increase in adverse events, indicating good tolerability of VK supplementation in this population.

背景和目的:肝细胞癌(HCC)是全球癌症相关死亡的第三大原因。补充维生素K (VK)对HCC患者的潜在益处尚不清楚。本研究旨在评估补充VK对HCC治疗患者临床结果的影响。方法:通过Medline, Scopus和Web of Science数据库进行系统搜索,确定相关研究。合并优势比(OR)和95%置信区间(CI)评估治疗组在二元结果方面的差异。采用I2统计量评估异质性。使用R(4.2.3版)进行分析。结果:纳入了11项研究,共1030例患者。与对照组相比,补充VK在1年(OR 0.55, 95% CI 0.32-0.97; p = 0.039)、2年(OR 0.52, 95% CI 0.35-0.77; p = 0.001)和3年(OR 0.41, 95% CI 0.25-0.67; p = 0.000)显著降低疾病复发(DR)。此外,补充VK显著降低了1年(OR 0.20, 95% CI 0.07-0.60; p = 0.004)、2年(OR 0.38, 95% CI 0.18-0.82; p = 0.014)和3年(OR 0.37, 95% CI 0.21-0.66; p = 0.001)的死亡率。值得注意的是,VK组与对照组的不良事件发生率无显著差异(OR 3.56, 95% CI 0.06-198.66; p = 0.536)。结论:本研究表明,在HCC患者中补充VK有实质性的益处,特别是在降低1年、2年和3年的DR和死亡率方面。重要的是,这些改善在没有显著增加不良事件的情况下实现,表明在该人群中补充VK具有良好的耐受性。
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引用次数: 0
Evaluation of the Relationship Between Sarcopenia, Nutritional Status, and Frailty in Older Patients with Cancer. 老年癌症患者肌肉减少症、营养状况和虚弱之间关系的评价。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI: 10.1080/01635581.2025.2582236
Diğdem Doğan Akagündüz, Hilal Şahin, Baran Akagündüz

Sarcopenia, malnutrition, and frailty frequently coexist in older adults with cancer, adversely affecting treatment tolerance, functional independence, and survival. While comprehensive geriatric assessment (CGA) is the gold standard for frailty evaluation, its resource-intensive nature limits routine use, and simple tools are needed. This cross-sectional study included 291 patients aged ≥70 years with histologically confirmed cancer, evaluated at a oncology outpatient clinic between January and November 2024. Sarcopenia was defined according to EWGSOP2 criteria: handgrip strength (HGS) and skeletal muscle index (SMI) by bioelectrical impedance analysis (BIA). Nutritional status was assessed with the Mini Nutritional Assessment-Short Form (MNA-SF), and frailty was defined as G8 ≤ 14. Additional measures included SARC-F, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale. The median age was 74 years, and 53% were male. Possible sarcopenia was identified in 39.5%, confirmed sarcopenia in 33.7%, severe sarcopenia in 26.8%. Nutritional risk was observed in 66.7%, and frailty in 44.7%. Frailty correlated strongly with nutritional status and moderately with muscle strength and mass. In multivariable analysis, low HGS, low SMI, nutritional risk, and depression independently predicted frailty. ROC analysis showed, G8 with HGS and nutritional assessment improved predictive accuracy. These findings highlight that simple measures enhance frailty detection and may support personalized care.

骨骼肌减少症、营养不良和虚弱在老年癌症患者中经常共存,对治疗耐受性、功能独立性和生存产生不利影响。虽然综合老年评估(CGA)是脆弱性评估的黄金标准,但其资源密集性限制了常规使用,并且需要简单的工具。这项横断面研究包括291例年龄≥70岁的组织学证实的癌症患者,于2024年1月至11月在肿瘤门诊进行评估。骨骼肌减少症根据EWGSOP2标准进行定义:通过生物电阻抗分析(BIA)测定握力(HGS)和骨骼肌指数(SMI)。采用Mini nutrition Assessment-Short Form (MNA-SF)评估营养状况,将虚弱定义为G8≤14。其他测量包括SARC-F、简易精神状态检查(MMSE)和老年抑郁量表。中位年龄为74岁,53%为男性。39.5%为可能的肌肉减少症,33.7%为确诊的肌肉减少症,26.8%为严重的肌肉减少症。有营养风险的占66.7%,虚弱的占44.7%。虚弱与营养状况密切相关,与肌肉力量和质量密切相关。在多变量分析中,低HGS、低SMI、营养风险和抑郁独立预测虚弱。ROC分析显示,G8结合HGS和营养评估提高了预测的准确性。这些发现强调,简单的措施可以提高虚弱的检测,并可能支持个性化护理。
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引用次数: 0
Prognostic Factors Affecting Iodine-131 Treatment Efficacy in Patients With Differentiated Thyroid Carcinoma: A Risk-Stratified Analysis. 影响分化型甲状腺癌患者碘-131治疗效果的预后因素:风险分层分析
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-12-07 DOI: 10.1080/01635581.2025.2596905
Jinhao Li, Huixia Geng, Junbo Nan, Fangfang Mao, Luoping Zhai, Wanchun Zhang

To analyze factors influencing iodine-131 (I-131) treatment efficacy in differentiated thyroid carcinoma (DTC). This retrospective study classified 299 patients with DTC into medium-low-risk and high-risk groups, assessing clinical data (preoperative stimulated thyroglobulin [ps-Tg], urinary iodine, gender, T stage, diet). Patients followed normal or iodine-restricted diets. Statistical analyses included t-tests, chi-squared tests and logistic regression. Medium-low risk and higher ps-Tg levels and urinary iodine concentrations correlated with less favorable outcomes (p < 0.001). High-risk patients showed significant differences in gender, T stage and ps-Tg level (p < 0.001). Multivariate analysis identified risk level, T stage and ps-Tg level as key prognostic factors (p < 0.001), with urinary iodine concentration having a minor effect (p = 0.003). Risk stratification, T stage and ps-Tg level were the primary prognostic determinants. Dietary interventions showed different effects in different risk-stratified patients, requiring individualized consideration. These findings emphasize the importance of comprehensive assessment in DTC management.

目的:分析碘-131治疗分化型甲状腺癌疗效的影响因素。本回顾性研究将299例DTC患者分为中、低危和高危两组,评估临床资料(术前促甲状腺球蛋白[ps-Tg]、尿碘、性别、T分期、饮食)。患者遵循正常或限碘饮食。统计分析包括t检验、卡方检验和逻辑回归。中低风险和较高的ps-Tg水平和尿碘浓度与不太有利的结果相关(p p p p = 0.003)。危险分层、T分期和ps-Tg水平是影响预后的主要因素。饮食干预在不同风险分层的患者中表现出不同的效果,需要个体化考虑。这些发现强调了综合评估在DTC管理中的重要性。
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引用次数: 0
GLR in Cholangiocarcinoma: A Practical Biomarker in Need of Validation. 胆管癌GLR:一种需要验证的实用生物标志物。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-10-11 DOI: 10.1080/01635581.2025.2570558
Pınar Peker, Aslı Geçgel, Oğuzcan Özkan
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引用次数: 0
Effectiveness of Nutritional Screening Tools in Predicting the Impact of Malnutrition on Hospital and Intensive Care Unit Stay. 营养筛查工具在预测营养不良对住院和重症监护病房的影响方面的有效性。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1080/01635581.2025.2584487
Chung-Yan Lee, Ping-Wen Shih, Chun-Hao Yin, Yao-Shen Chen, Ko-Huei Wu, Ying-Chun Li, Yi-Chia Su

Malnutrition commonly occurs in patients with esophageal cancer (EC) and head and neck cancers (HNCs), adversely affecting clinical outcomes. The comparative effectiveness of nutritional screening tools in predicting prolonged length of stay (PLOS) and intensive care unit (ICU) admission in this population remains unclear. We aimed to investigate the effectiveness of various nutritional screening techniques in predicting the hospital and ICU LOS of patients with HNCs/EC. We retrospectively analyzed the data of 374 patients aged ≥18 years with EC/HNC who underwent first-time surgery between January 2013 and December 2023. Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST), Controlling Nutritional Status (COUNT), Geriatric Nutritional Risk Index (GNRI), and Prognostic Nutritional Index (PNI). Patients were classified into low-risk and high-to-moderate-risk groups. The outcomes included ICU stay >2 days and PLOS (>16 days). The COUNT, GNRI, and PNI were significantly associated with ICU stays >2 days and PLOS. The PNI had the highest predictive accuracy (ICU >2 days: adjusted odds ratio [aOR] = 8.44; area under the ROC curve [AUC-ROC] = 0.864; PLOS: aOR = 6.39; AUC-ROC = 0.859). The PNI, COUNT, and GNRI effectively predicted ICU stay and PLOS among surgical patients with EC and HNC.

营养不良常见于食管癌(EC)和头颈癌(HNCs)患者,对临床结果产生不利影响。在这一人群中,营养筛查工具在预测延长住院时间(PLOS)和重症监护病房(ICU)入住方面的相对有效性尚不清楚。我们的目的是研究各种营养筛查技术在预测HNCs/EC患者的医院和ICU LOS中的有效性。我们回顾性分析了2013年1月至2023年12月期间首次接受手术的374例年龄≥18岁的EC/HNC患者的数据。采用营养不良普遍筛查工具(MUST)、控制营养状况(COUNT)、老年营养风险指数(GNRI)和预后营养指数(PNI)评估营养状况。患者被分为低危组和高至中度危组。结果包括ICU住院2天,PLOS住院16天。COUNT、GNRI和PNI与ICU住院天数和PLOS显著相关。PNI预测准确度最高(ICU >2天:调整优势比[aOR] = 8.44; ROC曲线下面积[AUC-ROC] = 0.864; PLOS: aOR = 6.39; AUC-ROC = 0.859)。PNI、COUNT和GNRI可有效预测EC和HNC手术患者的ICU住院时间和PLOS。
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引用次数: 0
A Scoping Review of Ultra-Processed Food Consumption and Cancer Risk: Implications for Public Health, Registered Dietitian Nutritionists and Other Healthcare Professionals. 超加工食品消费与癌症风险的范围综述:对公众健康、注册营养师、营养学家和其他医疗保健专业人员的影响。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-10-14 DOI: 10.1080/01635581.2025.2572122
Gabrielle DeVito, Patricia Sheean

Foods that are industrially created and/or heavily manipulated in the manufacturing process are conceptualized as ultra processed foods (UPFs), reflecting an emerging dietary target for chronic disease prevention. This scoping review provides updated evidence on associations between UPF consumption and cancer risk and identifies potential carcinogenic properties within UPFs, highlighting implications for food policies, Registered Dietitian Nutritionists (RDNs) and other healthcare professionals. Using the PubMed and Scopus databases, a comprehensive search was conducted (2010-2025). Eligible articles were required to be peer reviewed, published in English, observational in design, utilize the NOVA classification system, and examine cancer incidence. A total of 23 articles were included, and 15 reported a positive association between UPF intake and cancer incidence. This appeared more pronounced when cancer was considered one of many chronic diseases, and factoring in subgroup analyses within larger populations. Sugar-sweetened beverages and ultra-processed meats were isolated UPFs associated with higher cancer risk, allowing RDNs and other healthcare practitioners tangible dietary targets to impact cancer risk. Given the collective evidence, significant investment is needed in methodologies to comprehensively and reliably classify UPFs and to integrate UPFs into public health nutrition campaigns, dietary guidelines and food labels promoting a better food environment for all.

工业生产和/或在生产过程中大量加工的食品被概念化为超加工食品(upf),反映了慢性疾病预防的新兴饮食目标。这一范围审查提供了UPF消费与癌症风险之间关联的最新证据,并确定了UPF中潜在的致癌特性,强调了对食品政策、注册营养师和其他医疗保健专业人员的影响。利用PubMed和Scopus数据库进行全面检索(2010-2025)。符合条件的文章需要经过同行评议,以英文发表,采用观察性设计,使用NOVA分类系统,并检查癌症发病率。共纳入了23篇文章,其中15篇报道了UPF摄入量与癌症发病率之间的正相关。当癌症被认为是许多慢性疾病之一,并在更大的人群中进行亚组分析时,这一点显得更加明显。含糖饮料和超加工肉类是与更高癌症风险相关的孤立upf,这使得rdn和其他医疗保健从业者可以通过具体的饮食目标来影响癌症风险。鉴于这些集体证据,需要在方法方面进行大量投资,以便全面可靠地对普遍适用食品进行分类,并将普遍适用食品纳入公共卫生营养运动、膳食指南和食品标签,促进为所有人创造更好的食品环境。
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引用次数: 0
On FFMI as a Proxy for Muscle Mass, or How Redundancy and Multicollinearity Distort Inference. 关于FFMI作为肌肉质量的代理,或者冗余和多重共线性如何扭曲推理。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2026-01-01 Epub Date: 2025-10-27 DOI: 10.1080/01635581.2025.2581337
Jenny G Turcott, Eduardo Rios-Garcia, Cittim Palomares-Palomares, Oscar Arrieta
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引用次数: 0
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Nutrition and Cancer-An International Journal
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