Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2024.11.002
Jinyan Huang
Alzheimer's disease (AD) is a neurodegenerative disorder for which the cause is currently unknown, which has implications for drug development. In recent years, blood biomarkers have shown great potential in the early diagnosis of AD, and rapid advances in disease-modifying therapies have opened new possibilities for early treatment. In this article, we review the latest research on biomarkers related to Alzheimer's diagnosis and discuss the prospects of preclinical interventions, such as the use of natural extracts and probiotics in disease-modifying therapies (DMTs) via the gut-brain axis and other pathways, which provide new ideas for future therapeutic strategies and management of Alzheimer's disease.
{"title":"Review: New strategies for early dietary intervention in Alzheimer's disease","authors":"Jinyan Huang","doi":"10.1016/j.nupar.2024.11.002","DOIUrl":"10.1016/j.nupar.2024.11.002","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a neurodegenerative disorder for which the cause is currently unknown, which has implications for drug development. In recent years, blood biomarkers have shown great potential in the early diagnosis of AD, and rapid advances in disease-modifying therapies have opened new possibilities for early treatment. In this article, we review the latest research on biomarkers related to Alzheimer's diagnosis and discuss the prospects of preclinical interventions, such as the use of natural extracts and probiotics in disease-modifying therapies (DMTs) via the gut-brain axis and other pathways, which provide new ideas for future therapeutic strategies and management of Alzheimer's disease.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 15-21"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2025.01.002
Ece Nur Gulenay Sohret , Nazan Ulgen Tekerek , Alper Koker , Oguz Dursun
Purpose
This study aimed to assess parenteral nutrition (PN) practices in pediatric intensive care units (PICUs) in Turkey and compare them with existing literature.
Material and methods
A prospective survey was conducted among physicians from 37 PICUs. The survey, based on literature and guidelines, collected data that were statistically analyzed.
Results
Malnutrition was a significant factor in initiating PN in 91.9% of units, with the weight-for-height scale being the most common method (59.5%) for assessing malnutrition. PN was started within the first week in 73.9% of non-malnourished children who could not be fed enterally, while for chronically malnourished children, 27% initiated PN within 48 hours of admission. The most frequently used methods for determining PN amounts were the Holiday-Segar formula and body surface area calculations (56.8% and 45.9%, respectively). Energy requirements were mainly calculated based on weight (59.5%) or the Schofield formula (40.5%). Within the first week, 54.1% of units reached 2/3 of target calories in 75% of their patients. Ready-to-use solutions were preferred by 81.1% of units. The most common PN-related complications were electrolyte imbalances (31.3%) and infections (22.8%).
Conclusions
The study highlights the need for applicable guidelines and standardized nutrition education, emphasizing that factors like malnutrition frequency, methods for determining caloric needs, the availability of PN products, and unit capabilities are crucial considerations for developing country-specific guidelines.
{"title":"Evaluation of parenteral nutrition practices in pediatric intensive care units","authors":"Ece Nur Gulenay Sohret , Nazan Ulgen Tekerek , Alper Koker , Oguz Dursun","doi":"10.1016/j.nupar.2025.01.002","DOIUrl":"10.1016/j.nupar.2025.01.002","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to assess parenteral nutrition (PN) practices in pediatric intensive care units (PICUs) in Turkey and compare them with existing literature.</div></div><div><h3>Material and methods</h3><div>A prospective survey was conducted among physicians from 37 PICUs. The survey, based on literature and guidelines, collected data that were statistically analyzed.</div></div><div><h3>Results</h3><div>Malnutrition was a significant factor in initiating PN in 91.9% of units, with the weight-for-height scale being the most common method (59.5%) for assessing malnutrition. PN was started within the first week in 73.9% of non-malnourished children who could not be fed enterally, while for chronically malnourished children, 27% initiated PN within 48<!--> <!-->hours of admission. The most frequently used methods for determining PN amounts were the Holiday-Segar formula and body surface area calculations (56.8% and 45.9%, respectively). Energy requirements were mainly calculated based on weight (59.5%) or the Schofield formula (40.5%). Within the first week, 54.1% of units reached 2/3 of target calories in 75% of their patients. Ready-to-use solutions were preferred by 81.1% of units. The most common PN-related complications were electrolyte imbalances (31.3%) and infections (22.8%).</div></div><div><h3>Conclusions</h3><div>The study highlights the need for applicable guidelines and standardized nutrition education, emphasizing that factors like malnutrition frequency, methods for determining caloric needs, the availability of PN products, and unit capabilities are crucial considerations for developing country-specific guidelines.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 37-43"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2024.11.003
Joanna Magryś , Patrycja Bronowicka-Adamska
Background
Over the last decade, research has produced overwhelming evidence confirming the beneficial impact of vegan diet on health, as well as on implementation in the communicable disease prevention. Despite its various advantages, it may lead to nutritional deficiencies, which can have adverse effects on the human body.
Aim
The objective of this paper was to raise awareness of the potential risks associated with an imbalanced vegan diet during pregnancy and its impact on obstetric outcomes.
Methods
A comprehensive data analysis was conducted, focusing on the roles of nutrients that are often deficient in a vegan diet. The paper is based on a critical analysis of literature from databases such as PubMed, Google Scholar, Embase, Elsevier, and academic textbooks.
Findings
The analysis of scientific studies showed that during pregnancy, there is an increased demand for specific nutrients that are often deficient in a vegan diet (protein, individual amino acids, omega-3 polyunsaturated fatty acids, iron, calcium, iodine, zinc, vitamin D, and vitamin B12). Literature data confirmed that long-term cobalamin deficiency leads to serious health consequences such as: megaloblastic anemia, hyperhomocysteinemia and methylmalonic acidosis. Prevention of these disorders involves vitamin B12 supplementation.
Conclusion
A vegan diet can be safely followed during pregnancy if it is properly balanced and supplemented under the supervision of medical personnel. Nutritional deficiencies, particularly of vitamin B12, can negatively affect the course of pregnancy and obstetric outcomes.
{"title":"Impact of vegan diet on pregnancy outcome","authors":"Joanna Magryś , Patrycja Bronowicka-Adamska","doi":"10.1016/j.nupar.2024.11.003","DOIUrl":"10.1016/j.nupar.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Over the last decade, research has produced overwhelming evidence confirming the beneficial impact of vegan diet on health, as well as on implementation in the communicable disease prevention. Despite its various advantages, it may lead to nutritional deficiencies, which can have adverse effects on the human body.</div></div><div><h3>Aim</h3><div>The objective of this paper was to raise awareness of the potential risks associated with an imbalanced vegan diet during pregnancy and its impact on obstetric outcomes.</div></div><div><h3>Methods</h3><div>A comprehensive data analysis was conducted, focusing on the roles of nutrients that are often deficient in a vegan diet. The paper is based on a critical analysis of literature from databases such as PubMed, Google Scholar, Embase, Elsevier, and academic textbooks.</div></div><div><h3>Findings</h3><div>The analysis of scientific studies showed that during pregnancy, there is an increased demand for specific nutrients that are often deficient in a vegan diet (protein, individual amino acids, omega-3 polyunsaturated fatty acids, iron, calcium, iodine, zinc, vitamin D, and vitamin B12). Literature data confirmed that long-term cobalamin deficiency leads to serious health consequences such as: megaloblastic anemia, hyperhomocysteinemia and methylmalonic acidosis. Prevention of these disorders involves vitamin B12 supplementation.</div></div><div><h3>Conclusion</h3><div>A vegan diet can be safely followed during pregnancy if it is properly balanced and supplemented under the supervision of medical personnel. Nutritional deficiencies, particularly of vitamin B12, can negatively affect the course of pregnancy and obstetric outcomes.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 5-14"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2025.01.003
Qin Liyuan, He Yang, Chen Shu, Wu Beiwen
Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of exacerbation and remission. During remission, managing lifestyle factors, including diet, becomes crucial for maintaining patients’ well-being. This study aimed to assess the home dietary habits of IBD patients and identify dietary patterns that could potentially worsen their condition, to offer individualized dietary recommendations for IBD management. A cross-sectional survey was conducted with 157 IBD patients who visited a tertiary hospital in Shanghai between January 2022 and April 2023. Participants were selected based on inclusion criteria, such as confirmed IBD diagnosis and willingness to participate. The Chinese Healthy Diet Index (CHDI) was employed to evaluate their home diet patterns. Additionally, purposeful sampling was used to select a set of participants for semi-structured interviews, which explored factors influencing dietary choices. These interviews focused on disease-related dietary knowledge, family and social environment, economic support, and health awareness, providing a comprehensive view of the factors affecting diet in IBD patients. The mean CHDI score for IBD patients was 56.27 ± 9.58, indicating sub-optimal adherence to dietary guidelines. Dietary intake rates for whole grains, mixed beans and tubers, vegetables, fruits, dairy, fish, and soy products were notably low, all under 20%. These findings suggest a need for targeted dietary education and support. The study highlights the importance of improving disease-specific dietary knowledge and access to social support to enhance dietary management and reduce the risk of IBD exacerbation.
{"title":"Diet analysis of patients with inflammatory bowel disease in China","authors":"Qin Liyuan, He Yang, Chen Shu, Wu Beiwen","doi":"10.1016/j.nupar.2025.01.003","DOIUrl":"10.1016/j.nupar.2025.01.003","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of exacerbation and remission. During remission, managing lifestyle factors, including diet, becomes crucial for maintaining patients’ well-being. This study aimed to assess the home dietary habits of IBD patients and identify dietary patterns that could potentially worsen their condition, to offer individualized dietary recommendations for IBD management. A cross-sectional survey was conducted with 157 IBD patients who visited a tertiary hospital in Shanghai between January 2022 and April 2023. Participants were selected based on inclusion criteria, such as confirmed IBD diagnosis and willingness to participate. The Chinese Healthy Diet Index (CHDI) was employed to evaluate their home diet patterns. Additionally, purposeful sampling was used to select a set of participants for semi-structured interviews, which explored factors influencing dietary choices. These interviews focused on disease-related dietary knowledge, family and social environment, economic support, and health awareness, providing a comprehensive view of the factors affecting diet in IBD patients. The mean CHDI score for IBD patients was 56.27<!--> <!-->±<!--> <!-->9.58, indicating sub-optimal adherence to dietary guidelines. Dietary intake rates for whole grains, mixed beans and tubers, vegetables, fruits, dairy, fish, and soy products were notably low, all under 20%. These findings suggest a need for targeted dietary education and support. The study highlights the importance of improving disease-specific dietary knowledge and access to social support to enhance dietary management and reduce the risk of IBD exacerbation.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 57-62"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2024.10.006
Hilal Doğan Güney , Pınar Göbel , Özlem Özer Altundağ
Objective
Weight gain in individuals; in addition to physical and social life, it also negatively affects mental health and quality of life. However, it can cause social problems such as low self-esteem, depression and social stigma. This study, it was planned to examine the relationship between perceived social support, self-control and depression in individuals receiving medical nutrition therapy.
Methods
In total, 207 individuals (96 women, 111 men) received nutrition and diet counseling in a private clinic and were provided with medical nutrition treatment. The participants were closely monitored for 12 weeks. A survey including demographic information, anthropometric measurements, health and nutritional habits of individuals, a questionnaire including the Multidimensional Perceived Social Support Scale (MSPSS), Self-Control Scale (SCS) and Beck Depression Inventory (BDI) were repeated at the beginning and end of the study.
Results
The study results indicate a significant decrease in weight, BMI, waist circumference, hip circumference, waist/hip ratio, waist/height ratio, body fat percentage, body fat mass, lean body percentage, and lean body mass from the first measurement (P < 0.05). Furthermore, the final measurement MSPSS and SCS scores showed a significant increase (P < 0.001). The BDI score was also significantly lower (P < 0.001) compared to the first measurement.
Conclusion
This study confirms that long-term medical nutrition therapy has positive effects on body composition, perceived social support, self-control, and depression. Future research should focus on larger sample sizes and systematic diagnostic evaluations to further support these findings.
{"title":"An examination of the interrelationships among perceived social support, self-control, and depression in individuals undergoing medical nutrition treatment","authors":"Hilal Doğan Güney , Pınar Göbel , Özlem Özer Altundağ","doi":"10.1016/j.nupar.2024.10.006","DOIUrl":"10.1016/j.nupar.2024.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>Weight gain in individuals; in addition to physical and social life, it also negatively affects mental health and quality of life. However, it can cause social problems such as low self-esteem, depression and social stigma. This study, it was planned to examine the relationship between perceived social support, self-control and depression in individuals receiving medical nutrition therapy.</div></div><div><h3>Methods</h3><div>In total, 207 individuals (96 women, 111 men) received nutrition and diet counseling in a private clinic and were provided with medical nutrition treatment. The participants were closely monitored for 12<!--> <!-->weeks. A survey including demographic information, anthropometric measurements, health and nutritional habits of individuals, a questionnaire including the Multidimensional Perceived Social Support Scale (MSPSS), Self-Control Scale (SCS) and Beck Depression Inventory (BDI) were repeated at the beginning and end of the study.</div></div><div><h3>Results</h3><div>The study results indicate a significant decrease in weight, BMI, waist circumference, hip circumference, waist/hip ratio, waist/height ratio, body fat percentage, body fat mass, lean body percentage, and lean body mass from the first measurement (<em>P</em> <!--><<!--> <!-->0.05). Furthermore, the final measurement MSPSS and SCS scores showed a significant increase (<em>P</em> <!--><<!--> <!-->0.001). The BDI score was also significantly lower (<em>P</em> <!--><<!--> <!-->0.001) compared to the first measurement.</div></div><div><h3>Conclusion</h3><div>This study confirms that long-term medical nutrition therapy has positive effects on body composition, perceived social support, self-control, and depression. Future research should focus on larger sample sizes and systematic diagnostic evaluations to further support these findings.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 44-51"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In France, a number of guidelines provided by specialist medical societies supervises home parenteral nutrition, with the exception of the practice of supplementing mixtures. Heterogeneous supplementation practices for industrial parenteral nutrition mixtures at home have been observed across the country. The aim of this project is to provide an initial framework for this specific and high-risk practice carried out in patients’ homes.
Materials and methods
Good practice recommendations for home supplementation have been drawn up, following the methodology described by the French National Authority for Health (“Haute Autorité de Santé”) for drawing up good practice recommendations by formalized consensus, in association with the French-speaking society of clinical nutrition and metabolism (“Société Francophone de Nutrition Clinique et Métabolique”).
Results
Three working groups (pilot, rating, reading) brought together twenty-nine experts from the various professions involved in accredited home parenteral nutrition centers for adult patients. Twenty-six recommendations were drawn up.
Conclusion
This multi-professional project to draw up initial recommendations is part of the objective to harmonize practices and improve the quality and safety of care by improving the nutritional care management of patients at home.
目的在法国，由专业医学协会提供的一些指导方针监督家庭肠外营养，但补充混合物的做法除外。在全国各地都观察到在家中对工业肠外营养混合物进行异质补充的做法。该项目的目的是为在病人家中进行的这种特殊和高风险的做法提供一个初步框架。材料和方法根据法国国家卫生管理局（“ Haute autorit de sant “）与法语临床营养和代谢学会（” socie - de nutrition Clinique et msamtabolique ”）联合制定的以正式协商一致方式制定良好做法建议的方法，制定了家庭补充良好做法建议。结果三个工作组（试点、评级、阅读）汇集了29名来自经认证的成人患者家庭肠外营养中心的不同专业的专家。起草了26项建议。结论该多专业项目旨在通过改进家庭患者营养护理管理，协调实践，提高护理质量和安全。
{"title":"Supplémentation des mélanges de nutrition parentérale à domicile : recommandations de bonnes pratiques par consensus formalisé","authors":"Romane Chapuis , Marjorie Durand , Constance Chevrier , Eva Wilsius , Pierre-Nicolas Boivin , Olivia Dauriac , Philippe Fayemendy , Nicolas Flori , Nadia Gastaut , Roseline Mazet , Sébastien Neuville , Emmanuelle Olivier , Thierry Quessada , Jeanick Stocco , Julie Bataille , Stéphane Schneider","doi":"10.1016/j.nupar.2024.12.001","DOIUrl":"10.1016/j.nupar.2024.12.001","url":null,"abstract":"<div><h3>Objectives</h3><div>In France, a number of guidelines provided by specialist medical societies supervises home parenteral nutrition, with the exception of the practice of supplementing mixtures. Heterogeneous supplementation practices for industrial parenteral nutrition mixtures at home have been observed across the country. The aim of this project is to provide an initial framework for this specific and high-risk practice carried out in patients’ homes.</div></div><div><h3>Materials and methods</h3><div>Good practice recommendations for home supplementation have been drawn up, following the methodology described by the French National Authority for Health (“Haute Autorité de Santé”) for drawing up good practice recommendations by formalized consensus, in association with the French-speaking society of clinical nutrition and metabolism (“Société Francophone de Nutrition Clinique et Métabolique”).</div></div><div><h3>Results</h3><div>Three working groups (pilot, rating, reading) brought together twenty-nine experts from the various professions involved in accredited home parenteral nutrition centers for adult patients. Twenty-six recommendations were drawn up.</div></div><div><h3>Conclusion</h3><div>This multi-professional project to draw up initial recommendations is part of the objective to harmonize practices and improve the quality and safety of care by improving the nutritional care management of patients at home.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 22-36"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2024.10.005
Hawal Lateef Fateh , Dyari H. Ahmed , Hardy H. Rasul , Hassan M. Tawfeeq
Background
Infertility is a significant global health issue, with males contributing to 40–50% of cases. Male infertility is often linked to abnormal semen parameters, which are influenced by various environmental, nutritional, and lifestyle factors. Although individual nutrients have been shown to affect male fertility, thus the present study aimed to evaluate the association between Alternative Healthy Eating Index (AHEI) with semen quality of men attending fertility clinics.
Methods
This cross-sectional study was to evaluate the correlation between the Alternative Healthy Eating Index-2010 (AHEI-2010) and the quality of semen in a sample of 408 males who visited reproductive clinics in Kalar city, Kurdistan. The AHEI-2010 results categorize the participants into tertiles. A comprehensive assessment of semen quality conducted by measuring viscosity, volume, concentration, total sperm count, motility, and morphology. Dietary intake assessed by administering a 147-item food frequency questionnaire and computed AHEI-2010 scores after accounting for total energy consumption.
Results
Significant differences in semen parameters were observed across AHEI-2010 tertiles. Men in the highest tertile had a higher sperm concentration (35.9 ± 7.1 M/mL) and total sperm number (83.4 ± 18.7 M) compared to those in the lowest tertile with sperm concentration (15.3 ± 5.2 M/mL) and total sperm number (38.2 ± 12.6 M). Logistic regression analysis showed that men in highest tertile had significantly better odds of normal sperm motility (OR = 1.38, 95% CI: 1.11–1.71) and morphology (OR = 1.50, 95% CI: 1.22–1.85) compared to lowest tertile.
Conclusion
Higher AHEI-2010 scores are associated with improved semen quality among Kurdish men. These findings suggest that adherence to a healthier diet could be an effective strategy for improving male fertility in this population.
{"title":"Association between Alternative Healthy Eating Index (AHEI) with semen quality of men attending fertility clinics: A cross-sectional study","authors":"Hawal Lateef Fateh , Dyari H. Ahmed , Hardy H. Rasul , Hassan M. Tawfeeq","doi":"10.1016/j.nupar.2024.10.005","DOIUrl":"10.1016/j.nupar.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Infertility is a significant global health issue, with males contributing to 40–50% of cases. Male infertility is often linked to abnormal semen parameters, which are influenced by various environmental, nutritional, and lifestyle factors. Although individual nutrients have been shown to affect male fertility, thus the present study aimed to evaluate the association between Alternative Healthy Eating Index (AHEI) with semen quality of men attending fertility clinics.</div></div><div><h3>Methods</h3><div>This cross-sectional study was to evaluate the correlation between the Alternative Healthy Eating Index-2010 (AHEI-2010) and the quality of semen in a sample of 408 males who visited reproductive clinics in Kalar city, Kurdistan. The AHEI-2010 results categorize the participants into tertiles. A comprehensive assessment of semen quality conducted by measuring viscosity, volume, concentration, total sperm count, motility, and morphology. Dietary intake assessed by administering a 147-item food frequency questionnaire and computed AHEI-2010 scores after accounting for total energy consumption.</div></div><div><h3>Results</h3><div>Significant differences in semen parameters were observed across AHEI-2010 tertiles. Men in the highest tertile had a higher sperm concentration (35.9<!--> <!-->±<!--> <!-->7.1<!--> <!-->M/mL) and total sperm number (83.4<!--> <!-->±<!--> <!-->18.7<!--> <!-->M) compared to those in the lowest tertile with sperm concentration (15.3<!--> <!-->±<!--> <!-->5.2<!--> <!-->M/mL) and total sperm number (38.2<!--> <!-->±<!--> <!-->12.6<!--> <!-->M). Logistic regression analysis showed that men in highest tertile had significantly better odds of normal sperm motility (OR<!--> <!-->=<!--> <!-->1.38, 95% CI: 1.11–1.71) and morphology (OR<!--> <!-->=<!--> <!-->1.50, 95% CI: 1.22–1.85) compared to lowest tertile.</div></div><div><h3>Conclusion</h3><div>Higher AHEI-2010 scores are associated with improved semen quality among Kurdish men. These findings suggest that adherence to a healthier diet could be an effective strategy for improving male fertility in this population.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 79-86"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Côte d’Ivoire, the prevalence of hypothyroidism is 11.3% in the general population. There have been no studies of iodine levels in pregnant women, in whom iodine deficiency or excess is responsible for dysthyroidism and potentially severe complications.
Main objective
To assess the prevalence of dysthyroidism and iodine status in pregnant women.
Material and method
Descriptive cross-sectional study over 1 month (October 2023), measuring TSH, 24-hour ioduria and the iodine content of cooking salt in FE in 5 health facilities in the town of Man.
Results
One hundred and six FE were included: mean age 27 years ± 6.5 (min/max: 14/41). Biological hypothyroidism and hyperthyroidism were found respectively in 6.6% and 8.5% of EFs according to the ATA 2017 standard. Twenty-four-hour ioduria was below WHO standards (150 to 249 μg/L) in 66% of FEs (median/extreme: 130 μg/L/[80; 400]). Iodine deficiency assessed by ioduria/24 h was correlated with the iodine content of cooking salt (76.5% of salt < 15 ppm, 23.5% within the standard (WHO N:15 to 40 ppm). Sixty-five percent (65%) of EFs had ioduria/24 h below the recommended standard (P = 0.03).
Conclusion
The high prevalence of hypothyroidism in FE is associated with iodine deficiency in cooking salt, the main source of iodine intake, in areas far from the sea. Preventive measures in line with UNICEF recommendations (systematic iodine supplementation) should be implemented.
{"title":"Le statut iodé des femmes enceintes dans une zone d’endémie goitreuse à l’origine de dysthyroïdie dans la ville de Man (République de Côte d’Ivoire)","authors":"Souleymane Tandamba , Assita Yao , Joceline Danho , Nafi Ballo , Gnomblesson Georges Tiahou , Mouna Hanachi , Jacko Abodo","doi":"10.1016/j.nupar.2024.10.007","DOIUrl":"10.1016/j.nupar.2024.10.007","url":null,"abstract":"<div><h3>Introduction</h3><div>In Côte d’Ivoire, the prevalence of hypothyroidism is 11.3% in the general population. There have been no studies of iodine levels in pregnant women, in whom iodine deficiency or excess is responsible for dysthyroidism and potentially severe complications.</div></div><div><h3>Main objective</h3><div>To assess the prevalence of dysthyroidism and iodine status in pregnant women.</div></div><div><h3>Material and method</h3><div>Descriptive cross-sectional study over 1 month (October 2023), measuring TSH, 24-hour ioduria and the iodine content of cooking salt in FE in 5 health facilities in the town of Man.</div></div><div><h3>Results</h3><div>One hundred and six FE were included: mean age 27 years<!--> <!-->±<!--> <!-->6.5 (min/max: 14/41). Biological hypothyroidism and hyperthyroidism were found respectively in 6.6% and 8.5% of EFs according to the ATA 2017 standard. Twenty-four-hour ioduria was below WHO standards (150 to 249 μg/L) in 66% of FEs (median/extreme: 130 μg/L/[80; 400]). Iodine deficiency assessed by ioduria/24<!--> <!-->h was correlated with the iodine content of cooking salt (76.5% of salt<!--> <!--><<!--> <!-->15 ppm, 23.5% within the standard (WHO N:15 to 40 ppm). Sixty-five percent (65%) of EFs had ioduria/24<!--> <!-->h below the recommended standard (<em>P</em> <!-->=<!--> <!-->0.03).</div></div><div><h3>Conclusion</h3><div>The high prevalence of hypothyroidism in FE is associated with iodine deficiency in cooking salt, the main source of iodine intake, in areas far from the sea. Preventive measures in line with UNICEF recommendations (systematic iodine supplementation) should be implemented.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 52-56"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.nupar.2024.10.008
Dyari H. Ahmed , Hawal Lateef Fateh , Hardy H. Rasul
Since the effects of L-arginine supplementation on kidney function markers and body weight indicators are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of L-arginine supplementation on kidney function markers and body weight indicators. The study was designed, conducted, and reported according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statements. A systematic and comprehensive search was performed in several databases from inception up to May 18, 2024. The meta-analysis on the impact of L-arginine supplementation on kidney function markers and body weight indicators indicates that the overall effect of L-arginine supplementation on serum urea, combining different doses, revealed a significant reduction with a WMD of 62.23 (41.08, 83.038) and a P-value of 0.001. serum creatinine demonstrated a positive effect, with an overall WMD of 2.12 (0.84, 3.41) and a P-value of 0.001. The body weight markers waist circumference and total body weight displayed reductions in their levels, with overall WMDs of −9.25 (−21.85, 3.33) and −5.62 (−10.29, −0.95) respectively. Subgroup analysis based on dosage revealed more pronounced reductions in waist circumference for doses of more than 15 grams/day. Findings from this study suggest that an L-Arginine supplement might be beneficial to modulating kidney biomarkers and body weight indices such as waist circumference and total body weight.
{"title":"The impact of L-arginine supplementation on kidney functions and body weight indicators: Systematic review and meta-regression analysis of 16 randomized controlled trials","authors":"Dyari H. Ahmed , Hawal Lateef Fateh , Hardy H. Rasul","doi":"10.1016/j.nupar.2024.10.008","DOIUrl":"10.1016/j.nupar.2024.10.008","url":null,"abstract":"<div><div>Since the effects of L-arginine supplementation on kidney function markers and body weight indicators are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of L-arginine supplementation on kidney function markers and body weight indicators. The study was designed, conducted, and reported according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statements. A systematic and comprehensive search was performed in several databases from inception up to May 18, 2024. The meta-analysis on the impact of L-arginine supplementation on kidney function markers and body weight indicators indicates that the overall effect of L-arginine supplementation on serum urea, combining different doses, revealed a significant reduction with a WMD of 62.23 (41.08, 83.038) and a <em>P</em>-value of 0.001. serum creatinine demonstrated a positive effect, with an overall WMD of 2.12 (0.84, 3.41) and a <em>P</em>-value of 0.001. The body weight markers waist circumference and total body weight displayed reductions in their levels, with overall WMDs of −9.25 (−21.85, 3.33) and −5.62 (−10.29, −0.95) respectively. Subgroup analysis based on dosage revealed more pronounced reductions in waist circumference for doses of more than 15<!--> <!-->grams/day. Findings from this study suggest that an L-Arginine supplement might be beneficial to modulating kidney biomarkers and body weight indices such as waist circumference and total body weight.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 1","pages":"Pages 63-78"},"PeriodicalIF":0.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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