Nutrition Clinique et Metabolisme最新文献_第5页

The value of LAR and IL-6 in early diagnosis and prognostic assessment of severe acute pancreatitis LAR和IL-6在重症急性胰腺炎早期诊断及预后评估中的价值

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1016/j.nupar.2025.04.002

Lin Xu , Meng Lin , Chao Liu , Guochao Zhu

To analyze the clinical value of lactate dehydrogenase to albumin ratio (LAR) and interleukin-6 (IL-6) in the early diagnosis and prognostic assessment of severe acute pancreatitis (SAP). A retrospective study was conducted on 98 cases of acute pancreatitis patients. These patients were divided into two groups based on the severity of their condition: non-SAP group (n = 68) and SAP group (n = 30). Spearman correlation analysis was utilized to investigate the correlation of LAR and IL-6 with the bedside index for severity in acute pancreatitis (BISAP). Patients in the SAP group exhibited significantly higher LAR values and IL-6 levels compared to those in the non-SAP group (P < 0.05). The APR and IL-6 of SAP patients were significantly positively correlated with BISAP scores (R = 0.758, P < 0.001) (R = 0.660, P < 0.001). The diagnostic AUC of LAR and IL-6 for SAP were 0.742 (P < 0.001) and 0.749 (P < 0.001), respectively. The Logistic regression analysis demonstrated that LAR and IL-6 were independent risk factors for SAP (P < 0.05). The levels of LAR and IL-6 in the death subgroup were significantly higher than those in the survival subgroup (P < 0.05). The diagnostic AUC of LAR and IL-6 for poor prognosis of SAP were 0.971 (P < 0.001) and 0.713 (P = 0.055), respectively. LAR was an independent risk factor for poor prognosis in SAP patients (P < 0.05). Patients with SAP may exhibit abnormally elevated levels of LAR and IL-6. LAR and IL-6 are closely associated with the severity of the patient's condition, which can be applied in the diagnosis of SAP.

探讨乳酸脱氢酶与白蛋白比值（LAR）及白细胞介素-6 （IL-6）在重症急性胰腺炎（SAP）早期诊断及预后评估中的临床价值。对98例急性胰腺炎患者进行回顾性分析。这些患者根据病情严重程度分为两组：非SAP组（n = 68）和SAP组（n = 30）。采用Spearman相关分析探讨LAR和IL-6与急性胰腺炎严重程度床边指数（BISAP）的相关性。SAP组患者的LAR值和IL-6水平明显高于非SAP组(P <；0.05)。SAP患者APR、IL-6与BISAP评分呈显著正相关(R = 0.758, P <；0.001) (R = 0.660, P <；0.001)。LAR和IL-6对SAP的诊断AUC为0.742 (P <；0.001)和0.749 (P <；分别为0.001)。Logistic回归分析显示，LAR和IL-6是SAP的独立危险因素(P <；0.05)。死亡亚组LAR和IL-6水平显著高于生存亚组(P <；0.05)。LAR和IL-6对SAP预后不良的诊断AUC为0.971 (P <；0.001)和0.713 （P = 0.055）。LAR是SAP患者预后不良的独立危险因素(P <；0.05)。SAP患者可能表现为LAR和IL-6水平异常升高。LAR和IL-6与患者病情的严重程度密切相关，可用于SAP的诊断。

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引用次数: 0

Qualité de l’alimentation, activité physique et image corporelle d’adultes actifs : comparaison selon le rythme de travail (régulier jour/travail posté) 积极成年人的饮食质量、身体活动和身体形象：按工作节奏比较（每天定期工作/张贴工作）

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-06-01 Epub Date: 2025-02-04 DOI: 10.1016/j.nupar.2025.01.004

Chaima Boudaoud , Rabiâa Karoune , Ibrahim Sersar , Meriem Bencharif , Corinne Colette Dahel

Objectives

A healthy diet, regular physical activity and a positive body image are essential elements to maintain the physical and mental health of employees. The objective was to describe these aspects in workers, comparing those working during the day with those with cyclical work.

Materials and methods

Cross-sectional study by questionnaire divided into two groups according to the work rhythm: 140 day workers (DW) and 106 shift workers (SW). The data collected concerned their diet, physical activity, body image and anthropometric measurements.

Results

The study involved 246 men (age: 35.0 ± 8.1 years old). Smoking was dominant (89.8%; P = 0.0000). The average daily energy intake was 1861.2 ± 800.9 kcal/day (60.3% carbohydrates, 16.9% proteins, 22.6% lipids), with no difference between the two groups (P = 0.3671). The mean score of the Diet Quality Index-International (DQI-I) was 56.2 ± 9.3 points, with no difference between DW and SW (P = 0.1439). Non-athletes were predominant (55.3%; P = 0.0190). Employees spent 2.1 ± 1.4 hours/day in a sedentary position outside of work and DWs slept more (P = 0.0381). Excess weight was present in 54.1%. Among the employees, 31.7% had an erroneous perception of their body weight (under or overestimation). Body dissatisfaction concerned 59.8%.

Conclusion

SWs seemed to have similar aspects to DWs. Workers’ health is a global issue that requires interventions by occupational medicine, adapted to their specific needs, and beneficial for both individuals and the company.

目的健康的饮食、规律的体育锻炼和良好的身体形象是保持员工身心健康的基本要素。目的是描述工人的这些方面，比较那些白天工作的人和那些周期性工作的人。材料与方法采用问卷调查法进行横断面研究，根据工作节奏分为两组：140名白班工人（DW）和106名轮班工人（SW）。收集的数据涉及他们的饮食、身体活动、身体形象和人体测量值。结果共纳入246例男性（年龄：35.0±8.1岁）。吸烟占主导地位(89.8%；p = 0.0000)。平均日能量摄入为1861.2±800.9 kcal/d（碳水化合物60.3%，蛋白质16.9%，脂类22.6%），两组间差异无统计学意义（P = 0.3671）。饮食质量指数-国际（DQI-I）的平均得分为56.2±9.3分，DW与SW之间无差异（P = 0.1439）。非运动员居多（55.3%）；p = 0.0190)。员工在工作之外每天坐着的时间为2.1±1.4小时，dw的睡眠时间更长（P = 0.0381）。54.1%的人体重超标。31.7%的员工对自己的体重有错误的认知（低估或高估）。对身体不满意的占59.8%。结论sws与DWs有相似之处。工人健康是一个全球性问题，需要通过职业医学进行干预，适应他们的具体需要，对个人和公司都有利。

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引用次数: 0

Neurological level, acceptance of the modified diet, nutritional and water status after stroke 脑卒中后的神经水平、改良饮食的接受程度、营养和水分状况

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI: 10.1016/j.nupar.2025.02.003

Vânia Bentes de Miranda, Renata Ligia Guedes, Giedre Berretin-Félix

Introduction

Individuals affected by cerebrovascular accident (CVA) may present oropharyngeal dysphagia, which may lead to dehydration and nutritional deficiencies.

Objective

Assess the influence of the neurological level after the CVA in the acceptance of the modified food consistency after speech-language pathology assessment, consequently, in the nutritional and water status, in individuals assisted by an interdisciplinary team.

Methodology

Longitudinal observational study developed in a general hospital with nutritional assessments in three different times, obtaining BMI and body analysis by BIA. Dietary acceptance was quantified daily during hospitalization and sodium test results were evaluated as an indicator of hydration level. Data were statistically analyzed using Spearman's correlation coefficient, ANOVA test, and also the Bonferroni and paired T student. A significance level of 5% was considered for inferential analyses and the confidence interval was 95%.

Results

Sample composed predominantly of elderly males. No correlations were found between the change in food consistency and nutritional and water status, oral intake and food acceptance of the individuals, but a statistically significant difference in the variables NIHSS and BIAMM% was observed. Over time, the average course level decreased and the average bioelectrical impedance at time 2 was higher than that at time 3. There wasn’t a significative correlation between water status and neurological level.

Conclusion

No influence of the neurological level after stroke was observed on the acceptance of the modified diet or nutritional and hydration status. However, when the variables were analyzed in isolation a decrease in NIHSS values and muscle loss (BIAMM%) was observed.

受脑血管意外（CVA）影响的个体可能出现口咽吞咽困难，这可能导致脱水和营养缺乏。目的通过跨学科团队的辅助，评估CVA后神经学水平对言语语言病理评估后接受改良食物一致性的影响，从而对营养和水分状况的影响。方法在某综合医院开展纵向观察研究，在三个不同时间进行营养评估，获得BMI和BIA分析。住院期间每日量化饮食接受度，并评价钠试验结果作为水合水平的指标。数据采用Spearman相关系数、ANOVA检验及Bonferroni和配对T学生进行统计学分析。考虑5%的显著性水平进行推理分析，置信区间为95%。结果样本以老年男性为主。食物稠度的变化与营养和水分状况、口服摄入量和个体的食物接受度之间没有相关性，但变量NIHSS和BIAMM%的差异有统计学意义。随着时间的推移，平均课程水平下降，时间2的平均生物电阻抗高于时间3。水状态与神经学水平无显著相关。结论脑卒中后神经功能水平对改良饮食的接受程度及营养水合状况无明显影响。然而，当单独分析这些变量时，观察到NIHSS值和肌肉损失（BIAMM%）的下降。

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引用次数: 0

Review: New strategies for early dietary intervention in Alzheimer's disease 综述：阿尔茨海默病早期饮食干预的新策略

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1016/j.nupar.2024.11.002

Jinyan Huang

Alzheimer's disease (AD) is a neurodegenerative disorder for which the cause is currently unknown, which has implications for drug development. In recent years, blood biomarkers have shown great potential in the early diagnosis of AD, and rapid advances in disease-modifying therapies have opened new possibilities for early treatment. In this article, we review the latest research on biomarkers related to Alzheimer's diagnosis and discuss the prospects of preclinical interventions, such as the use of natural extracts and probiotics in disease-modifying therapies (DMTs) via the gut-brain axis and other pathways, which provide new ideas for future therapeutic strategies and management of Alzheimer's disease.

阿尔茨海默病（AD）是一种神经退行性疾病，其病因目前尚不清楚，这对药物开发具有重要意义。近年来，血液生物标志物在阿尔茨海默病的早期诊断中显示出巨大的潜力，而疾病修饰疗法的快速进展为早期治疗开辟了新的可能性。本文综述了与阿尔茨海默病诊断相关的生物标志物的最新研究进展，并对临床前干预的前景进行了展望，如利用天然提取物和益生菌通过肠-脑轴等途径进行疾病修饰治疗（DMTs），为未来阿尔茨海默病的治疗策略和管理提供新的思路。

引用次数: 0

Evaluation of parenteral nutrition practices in pediatric intensive care units 儿科重症监护病房的肠外营养实践评价

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1016/j.nupar.2025.01.002

Ece Nur Gulenay Sohret , Nazan Ulgen Tekerek , Alper Koker , Oguz Dursun

Purpose

This study aimed to assess parenteral nutrition (PN) practices in pediatric intensive care units (PICUs) in Turkey and compare them with existing literature.

Material and methods

A prospective survey was conducted among physicians from 37 PICUs. The survey, based on literature and guidelines, collected data that were statistically analyzed.

Results

Malnutrition was a significant factor in initiating PN in 91.9% of units, with the weight-for-height scale being the most common method (59.5%) for assessing malnutrition. PN was started within the first week in 73.9% of non-malnourished children who could not be fed enterally, while for chronically malnourished children, 27% initiated PN within 48 hours of admission. The most frequently used methods for determining PN amounts were the Holiday-Segar formula and body surface area calculations (56.8% and 45.9%, respectively). Energy requirements were mainly calculated based on weight (59.5%) or the Schofield formula (40.5%). Within the first week, 54.1% of units reached 2/3 of target calories in 75% of their patients. Ready-to-use solutions were preferred by 81.1% of units. The most common PN-related complications were electrolyte imbalances (31.3%) and infections (22.8%).

Conclusions

The study highlights the need for applicable guidelines and standardized nutrition education, emphasizing that factors like malnutrition frequency, methods for determining caloric needs, the availability of PN products, and unit capabilities are crucial considerations for developing country-specific guidelines.

目的本研究旨在评估土耳其儿科重症监护病房（picu）的肠外营养（PN）做法，并将其与现有文献进行比较。材料与方法对37个picu的内科医生进行前瞻性调查。该调查以文献和指南为基础，收集数据并进行统计分析。结果91.9%的单位营养不良是引起营养不良的重要因素，其中身高体重比量表是评估营养不良最常用的方法（59.5%）。73.9%不能肠内喂养的非营养不良儿童在第一周内开始了PN，而对于慢性营养不良儿童，27%在入院后48小时内开始了PN。确定PN量最常用的方法是Holiday-Segar公式和体表面积计算（分别为56.8%和45.9%）。能量需要量的计算主要基于体重（59.5%）或Schofield公式（40.5%）。在第一周内，54.1%的单位在75%的病人中达到了目标卡路里的2/3。81.1%的单位选择即用型溶液。最常见的pn相关并发症是电解质失衡（31.3%）和感染（22.8%）。该研究强调了制定适用指南和标准化营养教育的必要性，强调营养不良发生率、确定热量需求的方法、PN产品的可获得性和单位能力等因素是制定发展中国家特定指南的关键考虑因素。

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引用次数: 0

Impact of vegan diet on pregnancy outcome 素食对妊娠结局的影响

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1016/j.nupar.2024.11.003

Joanna Magryś , Patrycja Bronowicka-Adamska

Background

Over the last decade, research has produced overwhelming evidence confirming the beneficial impact of vegan diet on health, as well as on implementation in the communicable disease prevention. Despite its various advantages, it may lead to nutritional deficiencies, which can have adverse effects on the human body.

Aim

The objective of this paper was to raise awareness of the potential risks associated with an imbalanced vegan diet during pregnancy and its impact on obstetric outcomes.

Methods

A comprehensive data analysis was conducted, focusing on the roles of nutrients that are often deficient in a vegan diet. The paper is based on a critical analysis of literature from databases such as PubMed, Google Scholar, Embase, Elsevier, and academic textbooks.

Findings

The analysis of scientific studies showed that during pregnancy, there is an increased demand for specific nutrients that are often deficient in a vegan diet (protein, individual amino acids, omega-3 polyunsaturated fatty acids, iron, calcium, iodine, zinc, vitamin D, and vitamin B12). Literature data confirmed that long-term cobalamin deficiency leads to serious health consequences such as: megaloblastic anemia, hyperhomocysteinemia and methylmalonic acidosis. Prevention of these disorders involves vitamin B12 supplementation.

Conclusion

A vegan diet can be safely followed during pregnancy if it is properly balanced and supplemented under the supervision of medical personnel. Nutritional deficiencies, particularly of vitamin B12, can negatively affect the course of pregnancy and obstetric outcomes.

在过去的十年里，研究已经产生了压倒性的证据，证实了纯素饮食对健康的有益影响，以及在预防传染病方面的实施。尽管它有各种各样的优点，但它可能导致营养缺乏，这可能对人体产生不利影响。目的本文的目的是提高人们对怀孕期间不平衡素食饮食的潜在风险及其对产科结果的影响的认识。方法进行全面的数据分析，重点关注素食饮食中经常缺乏的营养素的作用。这篇论文是基于对PubMed、b谷歌Scholar、Embase、Elsevier和学术教科书等数据库文献的批判性分析。科学研究的分析表明，在怀孕期间，对纯素饮食中经常缺乏的特定营养素（蛋白质、单个氨基酸、omega-3多不饱和脂肪酸、铁、钙、碘、锌、维生素D和维生素B12）的需求增加。文献资料证实，长期钴胺素缺乏会导致严重的健康后果，如巨幼细胞性贫血、高同型半胱氨酸血症和甲基丙二酸中毒。预防这些疾病需要补充维生素B12。结论在医务人员的指导下，合理平衡和补充纯素饮食，是可以安全遵循妊娠期纯素饮食的。营养缺乏，特别是维生素B12缺乏，会对妊娠过程和产科结果产生负面影响。

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引用次数: 0

Diet analysis of patients with inflammatory bowel disease in China 中国炎症性肠病患者的饮食分析

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1016/j.nupar.2025.01.003

Qin Liyuan, He Yang, Chen Shu, Wu Beiwen

Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of exacerbation and remission. During remission, managing lifestyle factors, including diet, becomes crucial for maintaining patients’ well-being. This study aimed to assess the home dietary habits of IBD patients and identify dietary patterns that could potentially worsen their condition, to offer individualized dietary recommendations for IBD management. A cross-sectional survey was conducted with 157 IBD patients who visited a tertiary hospital in Shanghai between January 2022 and April 2023. Participants were selected based on inclusion criteria, such as confirmed IBD diagnosis and willingness to participate. The Chinese Healthy Diet Index (CHDI) was employed to evaluate their home diet patterns. Additionally, purposeful sampling was used to select a set of participants for semi-structured interviews, which explored factors influencing dietary choices. These interviews focused on disease-related dietary knowledge, family and social environment, economic support, and health awareness, providing a comprehensive view of the factors affecting diet in IBD patients. The mean CHDI score for IBD patients was 56.27 ± 9.58, indicating sub-optimal adherence to dietary guidelines. Dietary intake rates for whole grains, mixed beans and tubers, vegetables, fruits, dairy, fish, and soy products were notably low, all under 20%. These findings suggest a need for targeted dietary education and support. The study highlights the importance of improving disease-specific dietary knowledge and access to social support to enhance dietary management and reduce the risk of IBD exacerbation.

炎症性肠病（IBD）是一种以发作和缓解期为特征的慢性疾病。在缓解期间，管理生活方式因素，包括饮食，对于维持患者的健康至关重要。本研究旨在评估IBD患者的家庭饮食习惯，并确定可能使其病情恶化的饮食模式，为IBD治疗提供个性化的饮食建议。对2022年1月至2023年4月期间在上海一家三级医院就诊的157名IBD患者进行了横断面调查。参与者是根据纳入标准选择的，如确诊的IBD诊断和参与意愿。采用中国健康饮食指数（CHDI）对其家庭饮食模式进行评价。此外，我们采用有目的的抽样方法，选择一组参与者进行半结构化访谈，探讨影响饮食选择的因素。这些访谈集中在与疾病相关的饮食知识、家庭和社会环境、经济支持和健康意识等方面，为IBD患者的饮食影响因素提供了一个全面的观点。IBD患者的平均CHDI评分为56.27±9.58，表明对饮食指南的依从性不理想。全谷物、杂豆和块茎、蔬菜、水果、乳制品、鱼类和豆制品的膳食摄入量明显较低，均低于20%。这些发现表明需要有针对性的饮食教育和支持。该研究强调了提高疾病特异性饮食知识和获得社会支持的重要性，以加强饮食管理并降低IBD恶化的风险。

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引用次数: 0

An examination of the interrelationships among perceived social support, self-control, and depression in individuals undergoing medical nutrition treatment 在接受医疗营养治疗的个体中，观察到的社会支持、自我控制和抑郁之间的相互关系

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1016/j.nupar.2024.10.006

Hilal Doğan Güney , Pınar Göbel , Özlem Özer Altundağ

Objective

Weight gain in individuals; in addition to physical and social life, it also negatively affects mental health and quality of life. However, it can cause social problems such as low self-esteem, depression and social stigma. This study, it was planned to examine the relationship between perceived social support, self-control and depression in individuals receiving medical nutrition therapy.

Methods

In total, 207 individuals (96 women, 111 men) received nutrition and diet counseling in a private clinic and were provided with medical nutrition treatment. The participants were closely monitored for 12 weeks. A survey including demographic information, anthropometric measurements, health and nutritional habits of individuals, a questionnaire including the Multidimensional Perceived Social Support Scale (MSPSS), Self-Control Scale (SCS) and Beck Depression Inventory (BDI) were repeated at the beginning and end of the study.

Results

The study results indicate a significant decrease in weight, BMI, waist circumference, hip circumference, waist/hip ratio, waist/height ratio, body fat percentage, body fat mass, lean body percentage, and lean body mass from the first measurement (P < 0.05). Furthermore, the final measurement MSPSS and SCS scores showed a significant increase (P < 0.001). The BDI score was also significantly lower (P < 0.001) compared to the first measurement.

Conclusion

This study confirms that long-term medical nutrition therapy has positive effects on body composition, perceived social support, self-control, and depression. Future research should focus on larger sample sizes and systematic diagnostic evaluations to further support these findings.

目的：个体体重增加；除了身体和社会生活外，它还对心理健康和生活质量产生负面影响。然而，它会导致社会问题，如自卑、抑郁和社会耻辱。本研究旨在探讨接受医学营养治疗的个体，其感知社会支持、自我控制与抑郁之间的关系。方法共有207人（96名女性，111名男性）在私人诊所接受营养和饮食咨询，并接受医学营养治疗。研究人员对参与者进行了为期12周的密切监测。在研究开始和结束时重复进行人口统计信息、人体测量、健康和营养习惯调查，包括多维感知社会支持量表（MSPSS）、自我控制量表（SCS）和贝克抑郁量表（BDI）。结果研究结果表明，与第一次测量相比，体重、BMI、腰围、臀围、腰臀比、腰高比、体脂率、体脂质量、瘦体率和瘦体质量显著降低(P <；0.05)。此外，最终测量MSPSS和SCS得分均显着增加(P <；0.001)。BDI评分也显著降低(P <；0.001)。结论本研究证实长期药物营养治疗对身体成分、感知社会支持、自我控制和抑郁有积极影响。未来的研究应集中在更大的样本量和系统的诊断评估，以进一步支持这些发现。

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引用次数: 0

Issue contents 问题内容

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-02-17 DOI: 10.1016/S0985-0562(25)00008-1

引用次数: 0

Le statut iodé des femmes enceintes dans une zone d’endémie goitreuse à l’origine de dysthyroïdie dans la ville de Man (République de Côte d’Ivoire) 科特迪瓦马恩市甲状腺肿流行地区孕妇的碘化状况

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1016/j.nupar.2024.10.007

Souleymane Tandamba , Assita Yao , Joceline Danho , Nafi Ballo , Gnomblesson Georges Tiahou , Mouna Hanachi , Jacko Abodo

Introduction

In Côte d’Ivoire, the prevalence of hypothyroidism is 11.3% in the general population. There have been no studies of iodine levels in pregnant women, in whom iodine deficiency or excess is responsible for dysthyroidism and potentially severe complications.

Main objective

To assess the prevalence of dysthyroidism and iodine status in pregnant women.

Material and method

Descriptive cross-sectional study over 1 month (October 2023), measuring TSH, 24-hour ioduria and the iodine content of cooking salt in FE in 5 health facilities in the town of Man.

Results

One hundred and six FE were included: mean age 27 years ± 6.5 (min/max: 14/41). Biological hypothyroidism and hyperthyroidism were found respectively in 6.6% and 8.5% of EFs according to the ATA 2017 standard. Twenty-four-hour ioduria was below WHO standards (150 to 249 μg/L) in 66% of FEs (median/extreme: 130 μg/L/[80; 400]). Iodine deficiency assessed by ioduria/24 h was correlated with the iodine content of cooking salt (76.5% of salt < 15 ppm, 23.5% within the standard (WHO N:15 to 40 ppm). Sixty-five percent (65%) of EFs had ioduria/24 h below the recommended standard (P = 0.03).

Conclusion

The high prevalence of hypothyroidism in FE is associated with iodine deficiency in cooking salt, the main source of iodine intake, in areas far from the sea. Preventive measures in line with UNICEF recommendations (systematic iodine supplementation) should be implemented.

在Côte科特迪瓦，一般人群中甲状腺功能减退的患病率为11.3%。目前还没有关于孕妇碘水平的研究，在孕妇中，碘缺乏或过量会导致甲状腺功能障碍和潜在的严重并发症。主要目的了解孕妇甲状腺功能障碍的患病率及碘含量。材料与方法描述性横断面研究（2023年10月）历时1个月，测定了曼镇5个卫生机构FE中TSH、24小时碘含量和烹饪盐碘含量。结果共纳入106例FE患者，平均年龄27岁±6.5岁（min/max: 14/41）。根据ATA 2017标准，EFs中分别有6.6%和8.5%存在生物性甲状腺功能减退和甲状腺功能亢进。66%的FEs 24小时碘含量低于WHO标准（150 ~ 249 μg/L）(中位/极值：130 μg/L/[80；400])。碘尿量/24 h评价的碘缺乏与烹饪盐的碘含量相关(76.5%的盐<；15 ppm， 23.5%在标准范围内（WHO N:15至40 ppm）。65%的EFs患者碘尿/24 h低于推荐标准（P = 0.03）。结论FE甲减高发与远离海洋地区主要碘摄入来源烹调盐缺碘有关。应执行符合儿童基金会建议的预防措施（系统补充碘）。

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引用次数: 0