Nutrition Clinique et Metabolisme最新文献

{"title":"Association between MIND diet and dementia: A longitudinal observational meta-analysis","authors":"Hawal Lateef Fateh ,&nbsp;Dyari H. Ahmed","doi":"10.1016/j.nupar.2025.04.004","DOIUrl":"10.1016/j.nupar.2025.04.004","url":null,"abstract":"<div><div>Dementia, a leading global health concern associated with cognitive decline, has prompted interest in eating patterns to mitigate its onset. This systematic review and meta-analysis examined the impact of the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) on cognitive function and dementia risk. The MIND diet emphasizes neuroprotective foods, such as leafy greens, berries, nuts, whole grains, and fish, with the aim of reducing oxidative stress and inflammation. We reviewed longitudinal studies to evaluate the association between MIND diet adherence and cognitive outcome. A comprehensive literature search across PubMed, Web of Science, Embase, and Cochrane Library identified 14 eligible studies, including longitudinal studies, with a total sample size ranging significantly. Our findings indicate a pooled odds ratio of 0.79 (95% CI: 0.73 to 0.86) for dementia risk, suggesting a significant protective effect of the MIND diet. Additionally, cognitive decline analysis yielded a protective pooled effect size of 0.03 (95% CI: 0.02 to 0.03), albeit with high heterogeneity (I² <!-->=<!--> <!-->99.9%). These results underscore the potential of the MIND diet as an effective strategy for promoting cognitive health and reducing dementia risk in older adults. However, the variability in study design and dietary assessment methods suggests the need for further research, including well-designed randomized controlled trials, to establish causal relationships and explore the underlying mechanisms of diet effects.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 199-207"},"PeriodicalIF":0.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition of fatty acids in lipid emulsions and clinical outcomes in non-surgical critically ill patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Melika Hajimohammadebrahim-Ketabforoush ,&nbsp;Amene Saghazadeh ,&nbsp;Maryam Behfar ,&nbsp;Amir Ali Hamidieh ,&nbsp;Zahra Vahdat Shariatpanahi","doi":"10.1016/j.nupar.2025.06.006","DOIUrl":"10.1016/j.nupar.2025.06.006","url":null,"abstract":"<div><h3>Background &amp; objectives</h3><div>Increasing evidence has demonstrated that lipid emulsions are an essential part of nutrition therapy for critically-ill patients who are candidates for parenteral nutrition (PN). Meanwhile, determining the optimal lipid composition remains challenging, especially in non-surgical critically-ill patients. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing fatty acids in lipid emulsions and clinical outcomes in these patients.</div></div><div><h3>Methods</h3><div>Based on our predefined search strategy, PubMed, Cochrane, and Web of Science were searched for RCTs published up to 18 October 2023. The interventions included fish oil (FO), olive oil (OO), medium-chain triglyceride (MCT), and soybean oil (SO) or their mixture and were compared with traditional emulsions mostly based on 100% SO. The clinical outcomes evaluated included infections, mechanical ventilation, intensive care unit (ICU) length of stay (LOS), hospital LOS, ICU mortality, in-hospital mortality, and long-term mortality.</div></div><div><h3>Results</h3><div>A total of 802 articles were retrieved in the first stage of our search. Based on our predefined inclusion criteria, 9 articles were eligible for entering this meta-analysis. The studies had a low to moderate risk of bias. Hospital LOS was the only statistically significant outcome with a lower value in the treatment groups compared with the controls (Hedges's g −0.45; 95% CI −0.69, −0.20; <em>P</em> <!-->=<!--> <!-->0.00; I² <!-->=<!--> <!-->8.90%). Infection was identified as another statistically significant variable (Log odds-ratio 0.77; 95% CI 0.13, 1.42; <em>P</em> <!-->=<!--> <!-->0.02; I² <!-->=<!--> <!-->0%); however, only 2 articles in this regard were included in the meta-analysis.</div></div><div><h3>Conclusion</h3><div>The results of our meta-analysis highlighted a decrease in hospital LOS and infections. However, particularly regarding infections, more future studies are required. In accordance with previous meta-analyses, this findings highlight the superiority of mixed lipid emulsions consisting of FO/OO/MCT/SO, especially based on FO, over the traditional ones mostly based on SO, in non-surgical critically-ill patients who are candidates for PN.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 230-239"},"PeriodicalIF":0.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anorexia – Aromatic strategies in managing dietary changes in end-of-life patients","authors":"Sara Diogo Gonçalves","doi":"10.1016/j.nupar.2025.06.003","DOIUrl":"10.1016/j.nupar.2025.06.003","url":null,"abstract":"<div><div>Anorexia is a prevalent and challenging symptom in end-of-life care, significantly affecting patients’ nutritional status, energy levels, and overall quality of life. Traditional management approaches, including pharmacological appetite stimulants and dietary modifications, often have limited efficacy and may cause adverse effects. As a result, complementary therapies such as aromatherapy have gained interest for their potential role in appetite stimulation. Essential oils, derived from aromatic plants, act through olfactory stimulation, autonomic nervous system modulation, and biochemical interactions to enhance digestive function and appetite regulation. This review examines the therapeutic potential of essential oils, including citrus, ginger, peppermint, fennel, and chamomile, in managing anorexia among palliative care patients. These oils influence gastric motility, reduce nausea, and alleviate stress-related anorexia through complex neurophysiological mechanisms. Various administration methods, such as inhalation, topical application, and controlled ingestion, allow for tailored interventions suited to individual patient needs. Despite promising findings, further clinical research is required to establish standardized guidelines for safe and effective use. By integrating essential oils into palliative care strategies, healthcare providers can offer a holistic, non-invasive approach to improving appetite and overall well-being in patients facing advanced illness.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 180-192"},"PeriodicalIF":0.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary fiber on obese/overweight persons and its mechanism of action: A systematic and meta-analysis on randomized controlled trials","authors":"Dhananjay Sharma,&nbsp;Luxita Sharma,&nbsp;Debasrita Banerjee,&nbsp;Kajal Dhama","doi":"10.1016/j.nupar.2025.06.002","DOIUrl":"10.1016/j.nupar.2025.06.002","url":null,"abstract":"<div><h3>Aims and objectives</h3><div>The main objective of the study is to conduct a meta-analysis of randomized controlled trial studies to find the relationship between dietary fiber and its association with obesity and related symptoms.</div></div><div><h3>Methods</h3><div>A literature search was performed by electronic means on 9 January 2024 in databases like PubMed and Google Scholar, reviewing all the RCTs published in English. A comprehensive search strategy was developed to methodically identify the research on dietary fiber and weight reduction in obese persons. The search terminology for Google Scholar was “dietary fiber and obesity”, and for PubMed was “(Dietary fiber) AND (obesity)”. The qualitative assessment of the study was evaluated by the JBI checklist and strong-to-week study. Funnel plot, Hedges’ g, and Galbraith plot were drawn for the included study.</div></div><div><h3>Results</h3><div>There were 4313 articles found in the initial database search, 3930 in PubMed, 319 in Google Scholar, and 64 entries from additional sources. A significant correlation between dietary fiber and weight loss (d −0.67; 95% CI −1.04, −0.31; <em>P</em> <!-->˂<!--> <span>0.001), between the BMI and dietary fiber (d −0.37; 95% CI −0.70, −0.05; </span><em>P</em> <!-->=<!--> <!-->0.02), and a non-significant correlation between weight loss and dietary fiber (d −2.36; 95% CI −5.09, 0.37; <em>P</em> <!-->=<!--> <span>0.09) were found by meta-analytic pooling under a model based on random-effects. The result indicated a significant effect of the reduction of body weight, BMI, and body fat% after having a fiber-rich diet.</span></div></div><div><h3>Conclusion</h3><div>This meta-analysis examined a significant relationship between dietary fiber and obesity based on the included randomized controlled trial studies.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 164-179"},"PeriodicalIF":0.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of vitamin D deficiency in apparently healthy Indian children and adolescents: A systematic review and meta-analysis","authors":"Biplab Pal,&nbsp;Agripina Cletus Temba,&nbsp;Vaibhav Chaudhary,&nbsp;Sweta Kumari,&nbsp;Bhavya Sharma","doi":"10.1016/j.nupar.2025.06.001","DOIUrl":"10.1016/j.nupar.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Vitamin D is essential for bone health, calcium metabolism, and immune function. Despite ample sunlight, vitamin D deficiency is common among Indian children and adolescents due to limited sun exposure and poor dietary intake. This review measured the pooled prevalence of vitamin D deficiency and serum vitamin D levels in apparently healthy Indian children and adolescents (≤<!--> <!-->18 years).</div></div><div><h3>Methods</h3><div><span><span>A literature search was done in PubMed, </span>Embase, </span>Scopus, and Google Scholar for studies published up to September 2024. Eligible studies reported serum vitamin D levels and/or the prevalence of vitamin D deficiency in apparently healthy Indian children and adolescents. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist. Data analysis was done by RStudio using a random-effects model to estimate the pooled prevalence of vitamin D deficiency and mean serum vitamin D levels.</div></div><div><h3>Results</h3><div>A total of 23 cross-sectional studies with 38,762 participants were included. The pooled prevalence of vitamin D deficiency (&lt;<!--> <!-->20<!--> <!-->ng/ml) was 66.4% (95% CI: 59.0; 73.2). The pooled mean serum vitamin D level was 18.57<!--> <!-->ng/ml (95% CI: 15.46; 21.68). The highest prevalence was observed in Northern India (84.1%). Females (72.0%) had a higher deficiency rate than males (63.9%). Studies with larger sample sizes (&gt;<!--> <!-->400 participants) reported a prevalence of 77.7%, whereas studies with smaller sample sizes (≤<!--> <!-->400 participants) showed 53.8%.</div></div><div><h3>Conclusion</h3><div>Vitamin D deficiency is a major public health concern among Indian children and adolescents. Urgent interventions, such as food fortification, awareness campaigns, and supplementation programs, are needed to mitigate this issue.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 154-163"},"PeriodicalIF":0.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of type 2 diabetes and weight loss on serum CK-18 in MASLD patients","authors":"Shuang Zhao ,&nbsp;Jian-He Gan","doi":"10.1016/j.nupar.2025.05.001","DOIUrl":"10.1016/j.nupar.2025.05.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the characteristics of peripheral blood cytokeratin-18 fragments (CK-18) in the development of non-alcoholic fatty liver disease (MASLD), and to find an ideal marker for non-invasive diagnosis of MASLD.</div></div><div><h3>Methods</h3><div>A total of 85 patients with MASLD (abdominal B-ultrasound showed fat deposition) were selected. Serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT) were detected. There were 64 MASLD patients with normal ALT<span> and AST, and 21 MASLD patients with abnormal ALT. Among 64 MASLD patients with normal ALT and AST, 20 patients had type 2 diabetes. Twenty healthy individuals were randomly selected as the control group.</span></div></div><div><h3>Results</h3><div>The level of CK-18 M30 and CK-18 M65 in serum of MASLD patients was higher than that of healthy controls (<em>P</em> <!-->&lt;<!--> <!-->0.05). The serum CK-18 M30 and CK-18 M65 of MASLD patients with abnormal ALT was higher than that of patients with normal ALT and AST (<em>P</em> <!-->&lt;<!--> <!-->0.05). And serum CK18 M30 and CK-18 M65 in MASLD patients were positively correlated with ALT, but not with AST. Among 64 MASLD patients with normal ALT and AST, there was no statistically significant difference in CK-18 M30 and CK-18 M65 between MASLD patients with and without diabetes. Among all MASLD patients, 11 patients lost more than 5 percent of their weight during the study period. Compared with before weight loss, serum CK-18M30 decreased in the 11 patients after weight loss (<em>P</em> <!-->&lt;<!--> <!-->0.05). The decrease of serum CK-18 M65 in the 11 patients was not statistically significant.</div></div><div><h3>Conclusion</h3><div>The level of CK-18 in peripheral blood of MASLD patients is mainly related to serum ALT, but not to diabetes. And weight loss can reduce serum CK-18 M30.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 225-228"},"PeriodicalIF":0.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connaissances des recommandations de nutrition artificielle par les médecins","authors":"Vérane Peyratout Gueho,&nbsp;Simon Atmeare","doi":"10.1016/j.nupar.2025.05.002","DOIUrl":"10.1016/j.nupar.2025.05.002","url":null,"abstract":"<div><h3>Objective</h3><div>Nutrition, as a cross-disciplinary field, is sometimes difficult to fully integrate into daily medical practice, despite its complementarity with many specialties. Nevertheless, its prescription remains inconsistent, and a lack of knowledge or mastery of the various forms of artificial nutrition can hinder their appropriate use. This study aims to assess medical doctor's level of knowledge regarding current recommendations on artificial nutrition.</div></div><div><h3>Methods</h3><div>The study was conducted among 46 medical doctor at a peripheral hospital center involved in the nutritional management of adult patients. Participants answered four open-ended questions designed to explore their knowledge of current guidelines on artificial nutrition.</div></div><div><h3>Results</h3><div>The findings reveal a significant gap between the most recent recommendations and medical doctor’ knowledge, which may help explain the underprescription of appropriate nutritional support. Although oral, enteral, and parenteral nutrition are generally well known, some contraindications reported by respondents are not supported by current guidelines. The precautionary principle, patient refusal, and technical difficulties are frequently cited as barriers to prescription. Enteral nutrition is preferred as the first-line approach over parenteral nutrition, but its initiation is sometimes delayed due to negative perceptions (pain, discomfort, stigma). Additionally, social and technical factors contribute to a reluctance toward enteral nutrition, leading to the use of parenteral nutrition, sometimes inappropriately.</div></div><div><h3>Conclusion</h3><div>This survey highlights a gap between recommendations and clinical practice, underlining the importance of ongoing theoretical and practical training in clinical nutrition throughout the care pathway. Clarifying indications, improving communication with patients, and developing decision-support tools could enhance the relevance of nutritional prescriptions. Regular training in nutrition would help align medical practices with current guidelines, optimize the management of malnourished patients, and reduce associated complications. The issue is clinical, ethical, and medico-economic.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 150-153"},"PeriodicalIF":0.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Typologie des patients en situation d’obésité : place de l’outil numérique pour aider au phénotypage","authors":"Cyril Gauthier ,&nbsp;Clothilde Dumortier ,&nbsp;Marie-Claude Brindisi","doi":"10.1016/j.nupar.2025.04.006","DOIUrl":"10.1016/j.nupar.2025.04.006","url":null,"abstract":"<div><div>Today, obesity represents a major public health challenge. This pathology requires comprehensive, multi-professional, multimodal, adapted and exhaustive management, taking into account all associated co-morbidities. Precise phenotyping of patients suffering from obesity, based on the recommendations for good practice published in 2022, which goes far beyond BMI alone, is essential to adapt care and refer patients to the appropriate levels of care. This phenotyping can seem tedious. How can digital phenotyping overcome some of today's obstacles and help set up care pathways for obesity? That is what we’re going to discuss.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 219-224"},"PeriodicalIF":0.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue contents","authors":"","doi":"10.1016/S0985-0562(25)00037-8","DOIUrl":"10.1016/S0985-0562(25)00037-8","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 2","pages":"Page e1"},"PeriodicalIF":0.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Étude de la consommation de compléments alimentaires par les patients consultants en cabinet de médecine générale","authors":"Benjamin Dreiser ,&nbsp;Clara Gobin-Bourdet ,&nbsp;Stéphane Mouly ,&nbsp;Nicolas Mazer ,&nbsp;Philippe Zerr","doi":"10.1016/j.nupar.2025.04.005","DOIUrl":"10.1016/j.nupar.2025.04.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The consumption of food supplements (FS) affects between 22% and 59% of the French adult population, for uncertain benefits and potential risks. This study aimed to describe FS consumption among adult patients in general practice, estimate its prevalence, evaluate the physician's involvement in counseling, and identify associated consumption factors.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted between March and July 2023 through a self-administered questionnaire among adult patients consulting a general practitioner in Levallois-Perret (92), Île-de-France, France. Descriptive analysis and univariate associations were performed.</div></div><div><h3>Results</h3><div>Among the 202 participants, 55% were currently consuming FS and 25% had consumed them in the past. However, only 25% were aware of potential toxicity. On average, patients consumed 2 FS for an estimated cost of €18 per month and for 2 to 3 different health claims, mainly fatigue, sleep disorders, and aesthetic concerns. Female gender and BMI<!--> <!-->≥<!--> <!-->25<!--> <!-->kg/m² were significantly associated with aesthetic use. Male gender and regular physical activity were linked to muscle-related FS. Age was associated with cardiovascular health, aging, and joint/muscle pain. Although 66% of patients learned about FS through healthcare professionals and 82% considered it useful to discuss FS with their doctor, only 8% spontaneously disclosed their use during consultations.</div></div><div><h3>Conclusion</h3><div>Half of the patients consume FS, often with limited medical oversight. General practitioners have a key role in advising and monitoring, especially considering the potential risks and lack of high-quality evidence supporting FS efficacy.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 208-218"},"PeriodicalIF":0.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}