Nutrition Clinique et Metabolisme最新文献

英文中文

Influence of optimized nosocomial infection management model combined with nutritional support on the incidence of nosocomial infections and indoor bacterial count in surgical room patients 优化医院感染管理模式结合营养支持对手术室患者医院感染发生率及室内细菌计数的影响

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1016/j.nupar.2025.08.002

Runmei Pan , Liangmei Ouyang , Xiying Zhang, Jimei Huang, Yan Xiao , Yingfang Chen

Objective

This study aimed to investigate the impact of optimizing nosocomial infection management plus nutritional support on the incidence of nosocomial infections and the quantity of indoor bacteria in surgical patients.

Methods

A retrospective analysis was conducted on 400 surgical patients, rolled into Group A (n = 100, traditional nosocomial infection management + simple nutritional support), Group B (n = 100, traditional nosocomial infection management + complex nutritional support), Group C (n = 100, optimized nosocomial infection management + simple nutritional support), and Group D (n = 100, optimized nosocomial infection management + complex nutritional support). The incidence of nosocomial infections, indoor bacterial counts, and patient satisfaction were analyzed among the four groups.

Results

The postoperative air and hand bacterial counts in Groups C and D were lower than those in Groups A and B (P < 0.05). The preoperative preparation time and surgical time in Groups C and D were shorter than those in Groups A and B (P < 0.05). Patients in Groups C and D exhibited higher scores in nosocomial infection management quality compared to Groups A and B (P < 0.05). The number of highly satisfied patients in Group D was higher than that in Groups A, B, and C (P < 0.05).

Conclusion

Optimizing nosocomial infection management combined with complex nutritional support can reduce the counts of airborne and hand bacteria in surgical rooms, decrease the incidence of nosocomial infections, and demonstrate positive practical effects.

目的探讨优化医院感染管理加营养支持对外科患者院内感染发生率及室内细菌数量的影响。方法对400例外科手术患者进行回顾性分析，分为A组（n = 100，传统医院感染管理+简单营养支持）、B组（n = 100，传统医院感染管理+复杂营养支持）、C组（n = 100，优化医院感染管理+简单营养支持）和D组（n = 100，优化医院感染管理+复杂营养支持）。分析四组患者的医院感染发生率、室内细菌计数及患者满意度。结果C、D组术后空气及手部细菌计数均低于A、B组（P < 0.05）。C、D组术前准备时间和手术时间均短于A、B组（P < 0.05）。C组和D组患者医院感染管理质量得分高于A组和B组（P < 0.05）。D组高满意度患者数高于A、B、C组（P < 0.05）。结论优化医院感染管理结合复合营养支持可降低手术室空气细菌和手细菌数量，降低医院感染发生率，具有积极的实际效果。

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引用次数: 0

An update on gut microbiota: Its interaction with nutrients and metabolic syndrome 肠道菌群的最新进展：与营养物质和代谢综合征的相互作用

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-12-01 Epub Date: 2025-08-21 DOI: 10.1016/j.nupar.2025.08.001

Ijaz ul Haq , Maham Saeed

The intestinal microbiota has been identified as an important regulator of cellular metabolism and human health. The gut microbiota begins developing in infancy and is fully established by the age of three years. It has a strong connection with diet and food components, influencing general well-being, nutrition, and disease conditions. In this review, we examine the structural and functional composition of the intestinal microbiota, the various ways it affects metabolic activity, its complex interactions with food components, and its association with metabolic syndrome (MetS). Furthermore, we address the mechanisms by which intestinal microbes influence metabolic syndrome. We present a comprehensive body of research supporting the notion that gut microbiota-based therapies including probiotic and prebiotic supplementation, fecal microbiota transplantation (FMT), pharmacological modulation (e.g., metformin, liraglutide), and metabolic surgery, can be utilized to modify host metabolism and reduce MetS. Such approaches are likely to transition from the bench to the bedside in the near future.

肠道菌群已被确定为细胞代谢和人体健康的重要调节因子。肠道菌群在婴儿时期开始发育，并在三岁时完全建立。它与饮食和食物成分密切相关，影响总体健康、营养和疾病状况。在这篇综述中，我们研究了肠道微生物群的结构和功能组成，它影响代谢活动的各种方式，它与食物成分的复杂相互作用，以及它与代谢综合征（MetS）的关系。此外，我们解决了肠道微生物影响代谢综合征的机制。我们提出了一项全面的研究，支持基于肠道微生物群的治疗，包括益生菌和益生元补充，粪便微生物群移植（FMT），药理调节（如二甲双胍，利拉鲁肽）和代谢手术，可以用来改变宿主代谢和降低MetS。在不久的将来，这种方法可能会从临床试验过渡到临床应用。

引用次数: 0

L’été, une parenthèse pour nourrir l’esprit 滋养心灵的夏天

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-07-26 DOI: 10.1016/j.nupar.2025.07.001

Francisca Joly

引用次数: 0

Typologie des patients en situation d’obésité : place de l’outil numérique pour aider au phénotypage 肥胖患者类型学：利用数字工具进行表型分析

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-05-30 DOI: 10.1016/j.nupar.2025.04.006

Cyril Gauthier , Clothilde Dumortier , Marie-Claude Brindisi

Today, obesity represents a major public health challenge. This pathology requires comprehensive, multi-professional, multimodal, adapted and exhaustive management, taking into account all associated co-morbidities. Precise phenotyping of patients suffering from obesity, based on the recommendations for good practice published in 2022, which goes far beyond BMI alone, is essential to adapt care and refer patients to the appropriate levels of care. This phenotyping can seem tedious. How can digital phenotyping overcome some of today's obstacles and help set up care pathways for obesity? That is what we’re going to discuss.

如今，肥胖是一项重大的公共卫生挑战。这种病理需要综合、多专业、多模式、适应和详尽的管理，并考虑到所有相关的合并症。根据2022年发布的良好做法建议，对肥胖患者进行精确的表型分型，这远远超出了BMI本身，对于调整护理并将患者转介到适当的护理水平至关重要。这种表现型看起来很乏味。数字表现型如何克服当今的一些障碍，并帮助建立肥胖的护理途径？这就是我们要讨论的。

引用次数: 0

Effect of dietary fiber on obese/overweight persons and its mechanism of action: A systematic and meta-analysis on randomized controlled trials 膳食纤维对肥胖/超重者的影响及其作用机制：随机对照试验的系统和荟萃分析

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-06-26 DOI: 10.1016/j.nupar.2025.06.002

Dhananjay Sharma, Luxita Sharma, Debasrita Banerjee, Kajal Dhama

Aims and objectives

The main objective of the study is to conduct a meta-analysis of randomized controlled trial studies to find the relationship between dietary fiber and its association with obesity and related symptoms.

Methods

A literature search was performed by electronic means on 9 January 2024 in databases like PubMed and Google Scholar, reviewing all the RCTs published in English. A comprehensive search strategy was developed to methodically identify the research on dietary fiber and weight reduction in obese persons. The search terminology for Google Scholar was “dietary fiber and obesity”, and for PubMed was “(Dietary fiber) AND (obesity)”. The qualitative assessment of the study was evaluated by the JBI checklist and strong-to-week study. Funnel plot, Hedges’ g, and Galbraith plot were drawn for the included study.

Results

There were 4313 articles found in the initial database search, 3930 in PubMed, 319 in Google Scholar, and 64 entries from additional sources. A significant correlation between dietary fiber and weight loss (d −0.67; 95% CI −1.04, −0.31; P ˂ 0.001), between the BMI and dietary fiber (d −0.37; 95% CI −0.70, −0.05; P = 0.02), and a non-significant correlation between weight loss and dietary fiber (d −2.36; 95% CI −5.09, 0.37; P = 0.09) were found by meta-analytic pooling under a model based on random-effects. The result indicated a significant effect of the reduction of body weight, BMI, and body fat% after having a fiber-rich diet.

Conclusion

This meta-analysis examined a significant relationship between dietary fiber and obesity based on the included randomized controlled trial studies.

目的和目的本研究的主要目的是对随机对照试验研究进行荟萃分析，以发现膳食纤维与肥胖及其相关症状之间的关系。方法于2024年1月9日在PubMed、b谷歌Scholar等数据库中进行电子检索，检索已发表的所有英文rct。制定了一项全面的搜索策略，以系统地识别关于膳食纤维和肥胖人群减肥的研究。b谷歌Scholar的搜索术语是“膳食纤维和肥胖”，PubMed的搜索术语是“（膳食纤维）和（肥胖）”。通过JBI检查表和强-周研究对研究进行定性评估。纳入研究绘制漏斗图、Hedges图和Galbraith图。结果在初始数据库中检索到4313篇文章，PubMed检索到3930篇，b谷歌Scholar检索到319篇，其他来源检索到64篇。在基于随机效应的模型下，荟萃分析发现膳食纤维与体重减轻之间存在显著相关性（d - 0.67; 95% CI - 1.04, - 0.31； P小于0.001），BMI与膳食纤维之间存在显著相关性（d - 0.37; 95% CI - 0.70, - 0.05; P = 0.02），体重减轻与膳食纤维之间存在非显著相关性（d - 2.36; 95% CI - 5.09, 0.37; P = 0.09）。结果表明，富含纤维的饮食对体重、身体质量指数和体脂率的降低有显著影响。结论：本荟萃分析在纳入的随机对照试验研究的基础上检验了膳食纤维与肥胖之间的显著关系。

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引用次数: 0

Effects of type 2 diabetes and weight loss on serum CK-18 in MASLD patients 2型糖尿病和体重减轻对MASLD患者血清CK-18的影响

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-06-25 DOI: 10.1016/j.nupar.2025.05.001

Shuang Zhao , Jian-He Gan

Objective

To investigate the characteristics of peripheral blood cytokeratin-18 fragments (CK-18) in the development of non-alcoholic fatty liver disease (MASLD), and to find an ideal marker for non-invasive diagnosis of MASLD.

Methods

A total of 85 patients with MASLD (abdominal B-ultrasound showed fat deposition) were selected. Serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT) were detected. There were 64 MASLD patients with normal ALT and AST, and 21 MASLD patients with abnormal ALT. Among 64 MASLD patients with normal ALT and AST, 20 patients had type 2 diabetes. Twenty healthy individuals were randomly selected as the control group.

Results

The level of CK-18 M30 and CK-18 M65 in serum of MASLD patients was higher than that of healthy controls (P < 0.05). The serum CK-18 M30 and CK-18 M65 of MASLD patients with abnormal ALT was higher than that of patients with normal ALT and AST (P < 0.05). And serum CK18 M30 and CK-18 M65 in MASLD patients were positively correlated with ALT, but not with AST. Among 64 MASLD patients with normal ALT and AST, there was no statistically significant difference in CK-18 M30 and CK-18 M65 between MASLD patients with and without diabetes. Among all MASLD patients, 11 patients lost more than 5 percent of their weight during the study period. Compared with before weight loss, serum CK-18M30 decreased in the 11 patients after weight loss (P < 0.05). The decrease of serum CK-18 M65 in the 11 patients was not statistically significant.

Conclusion

The level of CK-18 in peripheral blood of MASLD patients is mainly related to serum ALT, but not to diabetes. And weight loss can reduce serum CK-18 M30.

目的探讨外周血细胞角蛋白-18片段（CK-18）在非酒精性脂肪性肝病（MASLD）发病过程中的特点，为非酒精性脂肪性肝病（MASLD）的无创诊断寻找理想的标志物。方法选取腹部b超显示脂肪沉积的MASLD患者85例。检测血清谷丙转氨酶（AST）和谷草转氨酶（ALT）。ALT和AST正常的MASLD患者64例，ALT和AST异常的MASLD患者21例，ALT和AST正常的MASLD患者中有20例为2型糖尿病。随机选取20名健康个体作为对照组。结果MASLD患者血清ck - 18m30、ck - 18m65水平明显高于健康对照组（P < 0.05）。ALT异常MASLD患者血清CK-18 M30、CK-18 M65高于ALT、AST正常患者（P < 0.05）。MASLD患者血清CK18 M30和CK-18 M65与ALT呈正相关，与AST无显著正相关。在64例ALT和AST正常的MASLD患者中，CK-18 M30和CK-18 M65在合并和非糖尿病的MASLD患者中差异无统计学意义。在所有MASLD患者中，有11名患者在研究期间体重减轻了5%以上。11例患者减肥后血清CK-18M30均较减肥前下降（P < 0.05）。11例患者血清ck - 18m65降低无统计学意义。结论MASLD患者外周血CK-18水平主要与血清ALT相关，与糖尿病无关。体重减轻可降低血清CK-18 M30。

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引用次数: 0

Issue contents 问题内容

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.1016/S0985-0562(25)00060-3

引用次数: 0

Anorexia – Aromatic strategies in managing dietary changes in end-of-life patients 厌食症-芳香策略在管理饮食改变临终病人

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-06-30 DOI: 10.1016/j.nupar.2025.06.003

Sara Diogo Gonçalves

Anorexia is a prevalent and challenging symptom in end-of-life care, significantly affecting patients’ nutritional status, energy levels, and overall quality of life. Traditional management approaches, including pharmacological appetite stimulants and dietary modifications, often have limited efficacy and may cause adverse effects. As a result, complementary therapies such as aromatherapy have gained interest for their potential role in appetite stimulation. Essential oils, derived from aromatic plants, act through olfactory stimulation, autonomic nervous system modulation, and biochemical interactions to enhance digestive function and appetite regulation. This review examines the therapeutic potential of essential oils, including citrus, ginger, peppermint, fennel, and chamomile, in managing anorexia among palliative care patients. These oils influence gastric motility, reduce nausea, and alleviate stress-related anorexia through complex neurophysiological mechanisms. Various administration methods, such as inhalation, topical application, and controlled ingestion, allow for tailored interventions suited to individual patient needs. Despite promising findings, further clinical research is required to establish standardized guidelines for safe and effective use. By integrating essential oils into palliative care strategies, healthcare providers can offer a holistic, non-invasive approach to improving appetite and overall well-being in patients facing advanced illness.

厌食症是临终关怀中一种普遍且具有挑战性的症状，显著影响患者的营养状况、能量水平和整体生活质量。传统的管理方法，包括药物食欲刺激和饮食调整，往往疗效有限，并可能引起不良反应。因此，芳香疗法等补充疗法因其在刺激食欲方面的潜在作用而引起了人们的兴趣。从芳香植物中提取的精油，通过嗅觉刺激、自主神经系统调节和生物化学相互作用来增强消化功能和调节食欲。本综述探讨了精油的治疗潜力，包括柑橘，姜，薄荷，茴香和洋甘菊，在管理厌食症姑息治疗患者。这些油通过复杂的神经生理机制影响胃运动，减轻恶心，缓解应激性厌食症。各种给药方法，如吸入、局部应用和控制摄入，允许量身定制的干预措施，以适应个别患者的需要。尽管有很好的发现，但需要进一步的临床研究来建立安全有效使用的标准化指南。通过将精油整合到姑息治疗策略中，医疗保健提供者可以提供一种整体的、非侵入性的方法来改善面临晚期疾病的患者的食欲和整体健康。

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引用次数: 0

Prevalence of vitamin D deficiency in apparently healthy Indian children and adolescents: A systematic review and meta-analysis 明显健康的印度儿童和青少年维生素D缺乏症的患病率：系统回顾和荟萃分析

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-06-26 DOI: 10.1016/j.nupar.2025.06.001

Biplab Pal, Agripina Cletus Temba, Vaibhav Chaudhary, Sweta Kumari, Bhavya Sharma

Background

Vitamin D is essential for bone health, calcium metabolism, and immune function. Despite ample sunlight, vitamin D deficiency is common among Indian children and adolescents due to limited sun exposure and poor dietary intake. This review measured the pooled prevalence of vitamin D deficiency and serum vitamin D levels in apparently healthy Indian children and adolescents (≤ 18 years).

Methods

A literature search was done in PubMed, Embase, Scopus, and Google Scholar for studies published up to September 2024. Eligible studies reported serum vitamin D levels and/or the prevalence of vitamin D deficiency in apparently healthy Indian children and adolescents. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist. Data analysis was done by RStudio using a random-effects model to estimate the pooled prevalence of vitamin D deficiency and mean serum vitamin D levels.

Results

A total of 23 cross-sectional studies with 38,762 participants were included. The pooled prevalence of vitamin D deficiency (< 20 ng/ml) was 66.4% (95% CI: 59.0; 73.2). The pooled mean serum vitamin D level was 18.57 ng/ml (95% CI: 15.46; 21.68). The highest prevalence was observed in Northern India (84.1%). Females (72.0%) had a higher deficiency rate than males (63.9%). Studies with larger sample sizes (> 400 participants) reported a prevalence of 77.7%, whereas studies with smaller sample sizes (≤ 400 participants) showed 53.8%.

Conclusion

Vitamin D deficiency is a major public health concern among Indian children and adolescents. Urgent interventions, such as food fortification, awareness campaigns, and supplementation programs, are needed to mitigate this issue.

维生素D对骨骼健康、钙代谢和免疫功能至关重要。尽管阳光充足，但由于日照不足和饮食摄入不良，维生素D缺乏症在印度儿童和青少年中很常见。本综述测量了表面健康的印度儿童和青少年（≤18岁）维生素D缺乏症和血清维生素D水平的综合流行率。方法在PubMed、Embase、Scopus和b谷歌Scholar中检索截至2024年9月发表的研究。符合条件的研究报告了明显健康的印度儿童和青少年血清维生素D水平和/或维生素D缺乏症的患病率。采用乔安娜布里格斯研究所（JBI）检查表评估研究质量。RStudio使用随机效应模型进行数据分析，以估计维生素D缺乏症的总患病率和平均血清维生素D水平。结果共纳入23项横断面研究，38,762名受试者。维生素D缺乏症（20 ng/ml）的总患病率为66.4% （95% CI: 59.0; 73.2）。合并后的平均血清维生素D水平为18.57 ng/ml （95% CI: 15.46; 21.68）。发病率最高的是印度北部（84.1%）。女性（72.0%）缺乏率高于男性（63.9%）。样本量较大（400人）的研究报告患病率为77.7%，而样本量较小（≤400人）的研究报告患病率为53.8%。结论维生素D缺乏症是印度儿童和青少年的主要公共卫生问题。需要采取紧急干预措施，如食品强化、提高认识运动和补充计划，以缓解这一问题。

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引用次数: 0

Association between MIND diet and dementia: A longitudinal observational meta-analysis MIND饮食与痴呆之间的关系：一项纵向观察荟萃分析

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-09-01 Epub Date: 2025-07-23 DOI: 10.1016/j.nupar.2025.04.004

Hawal Lateef Fateh , Dyari H. Ahmed

Dementia, a leading global health concern associated with cognitive decline, has prompted interest in eating patterns to mitigate its onset. This systematic review and meta-analysis examined the impact of the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) on cognitive function and dementia risk. The MIND diet emphasizes neuroprotective foods, such as leafy greens, berries, nuts, whole grains, and fish, with the aim of reducing oxidative stress and inflammation. We reviewed longitudinal studies to evaluate the association between MIND diet adherence and cognitive outcome. A comprehensive literature search across PubMed, Web of Science, Embase, and Cochrane Library identified 14 eligible studies, including longitudinal studies, with a total sample size ranging significantly. Our findings indicate a pooled odds ratio of 0.79 (95% CI: 0.73 to 0.86) for dementia risk, suggesting a significant protective effect of the MIND diet. Additionally, cognitive decline analysis yielded a protective pooled effect size of 0.03 (95% CI: 0.02 to 0.03), albeit with high heterogeneity (I² = 99.9%). These results underscore the potential of the MIND diet as an effective strategy for promoting cognitive health and reducing dementia risk in older adults. However, the variability in study design and dietary assessment methods suggests the need for further research, including well-designed randomized controlled trials, to establish causal relationships and explore the underlying mechanisms of diet effects.

痴呆症是与认知能力下降有关的全球主要健康问题，它促使人们对饮食模式产生兴趣，以减轻其发病。本系统综述和荟萃分析研究了地中海- dash饮食干预对神经退行性延迟（MIND）对认知功能和痴呆风险的影响。MIND饮食强调神经保护食物，如绿叶蔬菜、浆果、坚果、全谷物和鱼，目的是减少氧化应激和炎症。我们回顾了纵向研究，以评估MIND饮食依从性与认知结果之间的关系。通过PubMed、Web of Science、Embase和Cochrane图书馆的综合文献检索，确定了14项符合条件的研究，包括纵向研究，总样本量范围显著。我们的研究结果表明，痴呆风险的合并优势比为0.79 (95% CI: 0.73至0.86)，表明MIND饮食具有显著的保护作用。此外，认知衰退分析显示，尽管异质性很高（I2 = 99.9%），但保护性合并效应大小为0.03 （95% CI: 0.02至0.03）。这些结果强调了MIND饮食作为促进老年人认知健康和降低痴呆风险的有效策略的潜力。然而，研究设计和饮食评估方法的可变性表明需要进一步的研究，包括精心设计的随机对照试验，以建立因果关系并探索饮食影响的潜在机制。

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